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profileBeth Stevens, PH.D.

TitleAssociate Professor of Neurology
InstitutionBoston Children's Hospital
DepartmentNeurology
AddressChildrens Hospital
Kirby Ctr - CLS 12257
300 Longwood Ave
Boston MA 02115
Phone617/919-2979
Fax617/919-2772
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CA. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017 May 31; 9(392). PMID: 28566429.
    View in: PubMed
  2. Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 01 26; 541(7638):481-487. PMID: 28099414.
    View in: PubMed
  3. Hong S, Wilton DK, Stevens B, Richardson DS. Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function. Methods Mol Biol. 2017; 1538:155-167. PMID: 27943190.
    View in: PubMed
  4. Hammond TR, Stevens B. Increasing the neurological-disease toolbox using iPSC-derived microglia. Nat Med. 2016 Nov 08; 22(11):1206-1207. PMID: 27824814.
    View in: PubMed
  5. Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016 Aug 25; 166(5):1295-1307.e21. PMID: 27565350.
    View in: PubMed
  6. Schafer DP, Heller CT, Gunner G, Heller M, Gordon C, Hammond T, Wolf Y, Jung S, Stevens B. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife. 2016 Jul 26; 5. PMID: 27458802; PMCID: PMC4961457.
  7. Hong S, Stevens B. Microglia: Phagocytosing to Clear, Sculpt, and Eliminate. Dev Cell. 2016 Jul 25; 38(2):126-8. PMID: 27459063.
    View in: PubMed
  8. Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 06 23; 534(7608):538-43. PMID: 27337340.
    View in: PubMed
  9. Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716. PMID: 27033548.
    View in: PubMed
  10. Weinberg RA, Schuldiner M, Wu H, Stevens B, Nielsen J, Hiesinger PR, Hassan BA. All You Need Is Mentorship. Cell. 2016 Mar 10; 164(6):1092-3. PMID: 26967274.
    View in: PubMed
  11. Stevens B, Muthukumar AK. Cellular neuroscience. Differences among astrocytes. Science. 2016 Feb 19; 351(6275):813. PMID: 26912878.
    View in: PubMed
  12. Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Feb 11; 530(7589):177-83. PMID: 26814963; PMCID: PMC4752392.
  13. Hong S, Dissing-Olesen L, Stevens B. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:128-34. PMID: 26745839.
    View in: PubMed
  14. Chung WS, Welsh CA, Barres BA, Stevens B. Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci. 2015 Nov; 18(11):1539-1545. PMID: 26505565; PMCID: PMC4739631 [Available on 11/01/16].
  15. Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B. Microglia: Dynamic Mediators of Synapse Development and Plasticity. Trends Immunol. 2015 Oct; 36(10):605-13. PMID: 26431938; PMCID: PMC4841266 [Available on 10/01/16].
  16. Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CA. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015 Sep 23; 35(38):13029-42. PMID: 26400934.
    View in: PubMed
  17. Dissing-Olesen L, Hong S, Stevens B. New Brain Lymphatic Vessels Drain Old Concepts. EBioMedicine. 2015 Aug; 2(8):776-7. PMID: 26425672; PMCID: PMC4563157.
  18. Schafer DP, Stevens B. Microglia Function in Central Nervous System Development and Plasticity. Cold Spring Harb Perspect Biol. 2015 Jul 17; 7(10):a020545. PMID: 26187728.
    View in: PubMed
  19. Lehrman EK, Stevens B. Shedding light on glioma growth. Cell. 2015 May 07; 161(4):704-6. PMID: 25957677.
    View in: PubMed
  20. Schafer DP, Stevens B. Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages. Immunity. 2015 Apr 21; 42(4):600-2. PMID: 25902477.
    View in: PubMed
  21. Giera S, Deng Y, Luo R, Ackerman SD, Mogha A, Monk KR, Ying Y, Jeong SJ, Makinodan M, Bialas AR, Chang BS, Stevens B, Corfas G, Piao X. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015 Jan 21; 6:6121. PMID: 25607655; PMCID: PMC4302951.
  22. Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C. Astrocytes refine cortical connectivity at dendritic spines. Elife. 2014 Dec 17; 3. PMID: 25517933; PMCID: PMC4286724.
  23. Bilimoria PM, Stevens B. Microglia function during brain development: New insights from animal models. Brain Res. 2015 Aug 18; 1617:7-17. PMID: 25463024.
    View in: PubMed
  24. Schafer DP, Lehrman EK, Heller CT, Stevens B. An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp. 2014 Jun 08; (88). PMID: 24962472; PMCID: PMC4188069.
  25. Wu LJ, Stevens B, Duan S, MacVicar BA. Microglia in neuronal circuits. Neural Plast. 2013; 2013:586426. PMID: 24455310; PMCID: PMC3881580.
  26. Bialas AR, Stevens B. TGF-ß signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013 Dec; 16(12):1773-82. PMID: 24162655; PMCID: PMC3973738.
  27. Schafer DP, Stevens B. Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system. Curr Opin Neurobiol. 2013 Dec; 23(6):1034-40. PMID: 24157239; PMCID: PMC3907950.
  28. Bialas AR, Stevens B. Glia: regulating synaptogenesis from multiple directions. Curr Biol. 2012 Oct 09; 22(19):R833-5. PMID: 23058800.
    View in: PubMed
  29. Schafer DP, Lehrman EK, Stevens B. The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia. 2013 Jan; 61(1):24-36. PMID: 22829357; PMCID: PMC4082974.
  30. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012 May 24; 74(4):691-705. PMID: 22632727; PMCID: PMC3528177.
  31. Stephan AH, Barres BA, Stevens B. The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci. 2012; 35:369-89. PMID: 22715882.
    View in: PubMed
  32. Tremblay MÈ, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. The role of microglia in the healthy brain. J Neurosci. 2011 Nov 09; 31(45):16064-9. PMID: 22072657.
    View in: PubMed
  33. Ransohoff RM, Stevens B. Neuroscience. How many cell types does it take to wire a brain? Science. 2011 Sep 09; 333(6048):1391-2. PMID: 21903801.
    View in: PubMed
  34. Blank M, Fuerst PG, Stevens B, Nouri N, Kirkby L, Warrier D, Barres BA, Feller MB, Huberman AD, Burgess RW, Garner CC. The Down syndrome critical region regulates retinogeniculate refinement. J Neurosci. 2011 Apr 13; 31(15):5764-76. PMID: 21490218; PMCID: PMC3230532.
  35. Håvik B, Le Hellard S, Rietschel M, Lybæk H, Djurovic S, Mattheisen M, Mühleisen TW, Degenhardt F, Priebe L, Maier W, Breuer R, Schulze TG, Agartz I, Melle I, Hansen T, Bramham CR, Nöthen MM, Stevens B, Werge T, Andreassen OA, Cichon S, Steen VM. The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biol Psychiatry. 2011 Jul 01; 70(1):35-42. PMID: 21439553.
    View in: PubMed
  36. Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest. 2011 Apr; 121(4):1429-44. PMID: 21383504; PMCID: PMC3069778.
  37. Chu Y, Jin X, Parada I, Pesic A, Stevens B, Barres B, Prince DA. Enhanced synaptic connectivity and epilepsy in C1q knockout mice. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7975-80. PMID: 20375278; PMCID: PMC2867906.
  38. Schafer DP, Stevens B. Synapse elimination during development and disease: immune molecules take centre stage. Biochem Soc Trans. 2010 Apr; 38(2):476-81. PMID: 20298206.
    View in: PubMed
  39. Rosen AM, Stevens B. The role of the classical complement cascade in synapse loss during development and glaucoma. Adv Exp Med Biol. 2010; 703:75-93. PMID: 20711708.
    View in: PubMed
  40. Stevens B. Neuron-astrocyte signaling in the development and plasticity of neural circuits. Neurosignals. 2008; 16(4):278-88. PMID: 18635944.
    View in: PubMed
  41. Chen Y, Stevens B, Chang J, Milbrandt J, Barres BA, Hell JW. NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods. 2008 Jun 30; 171(2):239-47. PMID: 18471889; PMCID: PMC2678682.
  42. Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. The classical complement cascade mediates CNS synapse elimination. Cell. 2007 Dec 14; 131(6):1164-78. PMID: 18083105.
    View in: PubMed
  43. Ishibashi T, Dakin KA, Stevens B, Lee PR, Kozlov SV, Stewart CL, Fields RD. Astrocytes promote myelination in response to electrical impulses. Neuron. 2006 Mar 16; 49(6):823-32. PMID: 16543131; PMCID: PMC1474838.
  44. Stevens B. Cross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation. Novartis Found Symp. 2006; 276:162-75; discussion 175-80, 233-7, 275-81. PMID: 16805429.
    View in: PubMed
  45. Stevens B. Glia: much more than the neuron's side-kick. Curr Biol. 2003 Jun 17; 13(12):R469-72. PMID: 12814563.
    View in: PubMed
  46. Stevens B, Porta S, Haak LL, Gallo V, Fields RD. Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron. 2002 Dec 05; 36(5):855-68. PMID: 12467589; PMCID: PMC1201407.
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