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Levine, Robert
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Robert A. Levine, M.D.
Title
Professor of Medicine
Institution
Massachusetts General Hospital
Department
Medicine
Address
Massachusetts General Hospital
Cardiac Ultrasound Lab VB-5
55 Fruit St
Boston MA 02114
Phone
617/724-1981
Fax
617/726-8383
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01HL141917
(LEVINE, ROBERT A)
Apr 1, 2018 - Mar 31, 2022
NIH
Improving Mitral Compensation In Ischemic Regurgitation
Role: Principal Investigator
R01HL128099
(LEVINE, ROBERT A)
Dec 15, 2015 - Nov 30, 2020
NIH
Treating Ventricle and Valve: New Synergies for Ischemic LV Remodeling with MR
Role: Co-Principal Investigator
R01HL109506
(LEVINE, ROBERT A)
May 15, 2012 - Apr 30, 2017
NIH
Improving Mitral Compensation in Ischemic Regurgitation
Role: Co-Principal Investigator
R21HL072353
(LEVINE, ROBERT A)
Sep 30, 2002 - Jul 31, 2006
NIH
ACTIVE PATCH THERAPY FOR ISCHEMIC MITRAL REGURGITATION
Role: Principal Investigator
R01HL072265
(LEVINE, ROBERT A)
Mar 15, 2002 - Nov 30, 2014
NIH
Effect of Mitral Regurgitation on Ischemic LV Remodeling
Role: Principal Investigator
K24HL067434
(LEVINE, ROBERT A)
Jul 10, 2001 - Feb 28, 2013
NIH
ISCHEMIC MITRAL REGURGITATION: FROM MECHANISM TO THERAPY
Role: Principal Investigator
U18HS011131
(LEVINE, ROBERT A)
Sep 30, 2000 - Sep 29, 2004
NIH
TRANSLATING PREVENTION RESEARCH INTO PRACTICE
Role: Principal Investigator
R01NS039132
(LEVINE, ROBERT A)
Apr 28, 2000 - Mar 31, 2004
NIH
BIOPTERIN, CATECHOLAMINES, &NO IN REGULATING APOPTOSIS
Role: Principal Investigator
R21DC003255
(LEVINE, ROBERT A)
Jan 1, 1997 - Dec 31, 1999
NIH
HUMAN TINNITUS STUDIES WITH FUNCTIONAL MRI
Role: Principal Investigator
R01HL053702
(LEVINE, ROBERT A)
Aug 1, 1995 - Jul 31, 2000
NIH
NONINVASIVE QUANTITATION OF VALVULAR REGURGITATION
Role: Principal Investigator
R01HL038176
(LEVINE, ROBERT A)
Jul 1, 1987 - Nov 30, 2009
NIH
NEW TARGETED THERAPIES FOR ISCHEMIC MITRAL REGURGITATION
Role: Principal Investigator
R29HL038176
(LEVINE, ROBERT A)
Jul 1, 1987 - Jun 30, 1993
NIH
MECHANISM OF VENTRICULAR OUTFLOW OBSTRUCTION IN IHSS
Role: Principal Investigator
R23HL034392
(LEVINE, ROBERT A)
Jul 1, 1985 - Jun 30, 1988
NIH
THE MECHANISM OF VENTRICULAR OUTFLOW OBSTRUCTION IN IHSS
Role: Principal Investigator
R01NS020273
(LEVINE, ROBERT A)
Jul 1, 1984 - Jun 30, 1986
NIH
NEUROBIOLOGY OF ASYMMETRIES IN BRAINSTEM POTENTIALS
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Delling FN, Noseworthy PA, Adams DH, Basso C, Borger M, Bouatia-Naji N, Elmariah S, Evans F, Gerstenfeld E, Hung J, Le Tourneau T, Lewis J, Miller MA, Norris RA, Padala M, Perazzolo-Marra M, Shah DJ, Weinsaft JW, Enriquez-Sarano M,
Levine RA
. Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel. J Am Coll Cardiol. 2022 Dec 13; 80(24):2331-2347.
PMID:
36480975
.
Citations:
Fields:
Car
Cardiology
Marsit O,
Levine RA
, Beaudoin J. Reply: Another Road to Rome: Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2022 12 06; 80(23):e215.
PMID:
36456057
.
Citations:
Fields:
Car
Cardiology
Zoghbi WA,
Levine RA
, Flachskampf F, Grayburn P, Gillam L, Leipsic J, Thomas JD,
Kwong RY
, Vandervoort P, Chandrashekhar Y. Atrial Functional Mitral Regurgitation: A JACC: Cardiovascular Imaging Expert Panel Viewpoint. JACC Cardiovasc Imaging. 2022 11; 15(11):1870-1882.
PMID:
36357130
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Rosalia L, Ozturk C, Coll-Font J,
Fan Y
,
Nagata Y
, Singh M, Goswami D, Mauskapf A, Chen S, Eder RA, Goffer EM, Kim JH,
Yurista S
, Bonner BP, Foster AN,
Levine RA
,
Edelman ER
, Panagia M, Guerrero JL,
Roche ET
, Nguyen CT. A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis. Nat Biomed Eng. 2022 10; 6(10):1134-1147.
PMID:
36163494
; PMCID:
PMC9588718
.
Citations:
Fields:
Bio
Biomedical Engineering
Translation:
Animals
Churchill TW
,
Yucel E
, Deferm S,
Levine RA
,
Hung J
, Bertrand PB. Mitral Valve Dysfunction in Patients With Annular Calcification: JACC Review Topic of the Week. J Am Coll Cardiol. 2022 08 16; 80(7):739-751.
PMID:
35953139
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD,
Levine RA
,
Aikawa E
, Pibarot P, Beaudoin J. Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2022 08 02; 80(5):500-510.
PMID:
35902173
.
Citations:
Fields:
Car
Cardiology
Passos LSA, Nizet V,
Levine RA
,
Aikawa E
. Can we diagnose acute rheumatic fever early to maximize the success of secondary prophylaxis in rheumatic heart valve disease? Cardiovasc Res. 2022 07 20; 118(9):e62-e65.
PMID:
35862716
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
PH
Public Health
Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C,
Aikawa E
,
Levine RA
, Pibarot P, Clavel MA, Beaudoin J. Progression of aortic stenosis after an acute myocardial infarction. Open Heart. 2022 06; 9(1).
PMID:
35728891
; PMCID:
PMC9214429
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Animals
Kochav JD, Kim J, Judd R, Tak KA, Janjua E, Maciejewski AJ, Kim HW, Klem I, Heitner J, Shah D, Zoghbi WA, Shenoy C, Farzaneh-Far A, Polsani V, Villar-Calle P, Parker M, Judd KM, Khalique OK, Leon MB, Devereux RB,
Levine RA
, Kim RJ, Weinsaft JW. Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance. JACC Cardiovasc Imaging. 2022 07; 15(7):1212-1226.
PMID:
35798397
; PMCID:
PMC9273017
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Roselli C, Yu M,
Nauffal V
, Georges A, Yang Q, Love K,
Weng LC
, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W,
Muehlschlegel JD
, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J,
Levine RA
, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA,
Slaugenhaupt SA
, Dina C,
Lubitz SA
, Bouatia-Naji N,
Ellinor PT
, Milan DJ. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 05 01; 43(17):1668-1680.
PMID:
35245370
; PMCID:
PMC9649914
.
Citations:
2
Fields:
Car
Cardiology
Translation:
Humans
Alvandi Z,
Nagata Y
, Passos LSA,
Hashemi Gheinani A
, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A,
Adam RM
,
Aikawa E
,
Levine RA
,
Bischoff J
. Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. J Am Heart Assoc. 2022 04 05; 11(7):e023695.
PMID:
35348006
; PMCID:
PMC9075477
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Nagata Y
, Bertrand PB,
Levine RA
. Malignant Mitral Valve Prolapse: Risk and Prevention of Sudden Cardiac Death. Curr Treat Options Cardiovasc Med. 2022 May; 24(5):61-86.
PMID:
35784809
; PMCID:
PMC9241643
.
Citations:
Gomes NFA, Silva VR,
Levine RA
, Esteves WAM, de Castro ML, Passos LSA,
Dal-Bianco JP
, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO,
Aikawa E
, Hung J, Nunes MCP. Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling. Front Cardiovasc Med. 2022; 9:862382.
PMID:
35360029
; PMCID:
PMC8962951
.
Citations:
Passos LSA,
Jha PK
, Becker-Greene D,
Blaser MC
, Romero D,
Lupieri A
,
Sukhova GK
,
Libby P
,
Singh SA
, Dutra WO,
Aikawa M
,
Levine RA
, Nunes MCP,
Aikawa E
. Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. Circulation. 2022 02 15; 145(7):531-548.
PMID:
35157519
; PMCID:
PMC8869797
.
Citations:
2
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Cells
Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia LG,
Dal-Bianco JP
,
Levine RA
,
Aikawa M
,
Hung J
, Dutra WO, Nunes MCP,
Aikawa E
. Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty. Front Cardiovasc Med. 2021; 8:804111.
PMID:
35127864
; PMCID:
PMC8811173
.
Citations:
1
Deferm S, Bertrand PB,
Yucel E
, Bernard S, Namasivayam M,
Nagata Y
,
Dal-Bianco JP
, Sanborn DY,
Picard MH
,
Levine RA
, Hung J,
Churchill TW
. Impact of Pulmonary Hypertension on Outcomes in Patients With Mitral Annular Calcium and Associated Mitral Valve Dysfunction. Am J Cardiol. 2022 03 15; 167:76-82.
PMID:
34991846
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Morningstar JE, Gensemer C, Moore R, Fulmer D, Beck TC, Wang C, Moore K, Guo L, Sieg F,
Nagata Y
, Bertrand P, Spampinato RA, Glover J, Poelzing S, Gourdie RG, Watts K, Richardson WJ,
Levine RA
, Borger MA, Norris RA. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. J Am Heart Assoc. 2021 12 21; 10(24):e022332.
PMID:
34873924
; PMCID:
PMC9075228
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Animals
Rong LQ, Lopes AJ, Mitlak HW, Palumbo MC, Mick S, Kim J,
Levine RA
, Wong SC, Reisman M, Devereux RB, Gaudino M, Weinsaft JW. Relative Impact of Surgical Mitral Repair and MitraClip on Annular Remodeling-A Potential Mechanism for Therapeutic Response to Mitral Repair for Degenerative Mitral Regurgitation. J Cardiothorac Vasc Anesth. 2022 05; 36(5):1279-1287.
PMID:
34600832
; PMCID:
PMC9027699
.
Citations:
Fields:
Ane
Anesthesiology
Car
Cardiology
Pul
Pulmonary Medicine
Translation:
Humans
Lupieri A
,
Nagata Y
, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H,
Hung JW
,
Singh SA
,
Bischoff J
,
Levine RA
,
Aikawa E
. Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients. Front Cardiovasc Med. 2021; 8:688396.
PMID:
34458332
; PMCID:
PMC8387660
.
Citations:
Deferm S, Bertrand PB, Verhaert D, Verbrugge FH, Dauw J, Thoelen K, Giesen A, Bruckers L, Rega F, Thomas JD,
Levine RA
, Vandervoort PM. Mitral Annular Dynamics in AF Versus Sinus Rhythm: Novel Insights Into the Mechanism of AFMR. JACC Cardiovasc Imaging. 2022 01; 15(1):1-13.
PMID:
34274270
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Levine RA
,
Nagata Y
. Imaging Cardiac Valve Mechanics: A New Frontier. JACC Cardiovasc Imaging. 2021 04; 14(4):794-796.
PMID:
33832662
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Kochav JD, Kim J, Judd R, Kim HW, Klem I, Heitner J, Shah D, Shenoy C, Farzaneh-Far A, Polsani V, Kalil R, Villar-Calle P, Nambiar L, Sultana R, Parker M, Cargile P, Khalique OK, Leon MB, Karmpaliotis D, Ratcliffe M,
Levine R
, Zoghbi WA, Devereux RB, Moskowitz CS, Kim R, Weinsaft JW. Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2021 04; 14(4):826-839.
PMID:
33744130
; PMCID:
PMC8086776
.
Citations:
2
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Bertrand PB, Overbey JR,
Zeng X
,
Levine RA
, Ailawadi G, Acker MA, Smith PK, Thourani VH, Bagiella E, Miller MA, Gupta L, Mack MJ, Gillinov AM, Giustino G, Moskowitz AJ, Gelijns AC, Bowdish ME,
O'Gara PT
, Gammie JS,
Hung J
. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2021 02 16; 77(6):713-724.
PMID:
33573741
; PMCID:
PMC7953587
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Dal-Bianco JP
,
Levine RA
,
Hung J
. Mitral Regurgitation Postinfarction: The Mitral Valve Adapts to the Times. Circ Cardiovasc Imaging. 2020 12; 13(12):e012130.
PMID:
33317331
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Bertrand PB,
Churchill TW
,
Yucel E
, Namasivayam M, Bernard S,
Nagata Y
, He W, Andrews CT,
Picard MH
,
Weyman AE
,
Levine RA
,
Hung J
. Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction. Eur Heart J. 2020 12 01; 41(45):4321-4328.
PMID:
33221855
.
Citations:
3
Fields:
Car
Cardiology
Translation:
Humans
Onoue T, Iwataki M, Araki M, Akashi J, Kitano T, Nabeshima Y, Hei S,
Nagata Y
, Hayashi A, Tsuda Y, Sonoda S, Fujino Y,
Levine RA
, Otsuji Y. Novel noninvasive estimation of mixed venous oxygen saturation by echocardiography and expired gas analysis. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H1078-H1086.
PMID:
32946269
.
Citations:
1
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Humans
Nunes MCP,
Levine RA
, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X,
Dal-Bianco JP
, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC,
Aikawa E
, Hung J. Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes. JACC Cardiovasc Imaging. 2020 12; 13(12):2513-2526.
PMID:
32950446
.
Citations:
2
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Bertrand PB,
Nagata Y
, Namasivayam M,
Levine RA
. The Artifact that Tells the Truth: Color Doppler Splay Unmasking Significant Mitral Regurgitation. J Am Soc Echocardiogr. 2020 10; 33(10):1220-1222.
PMID:
32855003
.
Citations:
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Kim J, Yum B, Palumbo MC, Sultana R, Wright N, Das M, You C, Moskowitz CS,
Levine RA
, Devereux RB, Weinsaft JW. Left Atrial Strain Impairment Precedes Geometric Remodeling as a Marker of Post-Myocardial Infarction Diastolic Dysfunction. JACC Cardiovasc Imaging. 2020 10; 13(10):2099-2113.
PMID:
32828776
.
Citations:
8
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Nagata Y
, Iwataki M, Nabeshima Y, Hei S, Onoue T, Hayashi A, Otani K, Tsuda Y, Araki M, Kim DH, Song JK, Hayashida A, Toki M, Yuasa T, Mizukami N, Nishimura Y,
Levine RA
, Otsuji Y. Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H694-H704.
PMID:
32795182
.
Citations:
1
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Humans
Bartko PE, Hülsmann M, Hung J, Pavo N,
Levine RA
, Pibarot P, Vahanian A, Stone GW, Goliasch G. Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction. Eur Heart J. 2020 08 01; 41(29):2799-2810.
PMID:
32350503
; PMCID:
PMC8453270
.
Citations:
8
Fields:
Car
Cardiology
Translation:
Humans
Namasivayam M, He W,
Churchill TW
, Capoulade R, Liu S,
Lee H
,
Danik JS
,
Picard MH
, Pibarot P,
Levine RA
,
Hung J
. Transvalvular Flow Rate Determines Prognostic Value of Aortic Valve Area in Aortic Stenosis. J Am Coll Cardiol. 2020 04 21; 75(15):1758-1769.
PMID:
32299587
; PMCID:
PMC8087111
.
Citations:
10
Fields:
Car
Cardiology
Translation:
Humans
Liu S, Churchill J, Hua L,
Zeng X
, Rhoades V, Namasivayam M,
Baliyan V
,
Ghoshhajra BB
, Dong T,
Dal-Bianco JP
,
Passeri JJ
,
Levine RA
,
Hung J
. Direct Planimetry of Left Ventricular Outflow Tract Area by Simultaneous Biplane Imaging: Challenging the Need for a Circular Assumption of the Left Ventricular Outflow Tract in the Assessment of Aortic Stenosis. J Am Soc Echocardiogr. 2020 04; 33(4):461-468.
PMID:
32248906
.
Citations:
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Yang LT, Ahn SW, Li Z, Benfari G, Mankad R, Takeuchi M,
Levine RA
, Enriquez-Sarano M, Michelena HI. Mitral Valve Prolapse Patients with Less than Moderate Mitral Regurgitation Exhibit Early Cardiac Chamber Remodeling. J Am Soc Echocardiogr. 2020 07; 33(7):815-825.e2.
PMID:
32222479
.
Citations:
3
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Cristina de Castro Faria S, Costa HS, Hung J, Gorle de Miranda Chaves A, Paes de Oliveira FA, Padilha da Silva JL, Esteves WAM, Tan TC,
Levine RA
, Pereira Nunes MC. Pulmonary Artery Systolic Pressure Response to Exercise in Patients with Rheumatic Mitral Stenosis: Determinants and Prognostic Value. J Am Soc Echocardiogr. 2020 05; 33(5):550-558.
PMID:
32127221
.
Citations:
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J,
Levine RA
, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2020 02 04; 75(4):395-405.
PMID:
32000951
; PMCID:
PMC7946170
.
Citations:
4
Fields:
Car
Cardiology
Translation:
Animals
Cells
Hei S, Iwataki M, Jang JY, Kuwaki H, Fukuda S, Kim YJ, Toki M, Onoue T, Hayashi A, Nishino S, Watanabe N, Hayashida A, Tsuda Y, Araki M, Nishimura Y, Song JK, Yoshida K,
Levine RA
, Otsuji Y. Relations of Augmented Systolic Annular Expansion and Leaflet/Papillary Muscle Dynamics in Late-Systolic Mitral Valve Prolapse Evaluated by Echocardiography with a Speckle Tracking Analysis. Int Heart J. 2020; 61(5):970-978.
PMID:
32999196
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Kim J, Palumbo MC, Khalique OK, Rong LQ, Sultana R, Das M, Jantz J, Nagata Y, Devereux RB, Wong SC, Bergman GW,
Levine RA
, Ratcliffe MB, Weinsaft JW. Transcatheter MitraClip repair alters mitral annular geometry - device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response. Cardiovasc Ultrasound. 2019 Dec 26; 17(1):31.
PMID:
31878931
; PMCID:
PMC6933704
.
Citations:
3
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS,
Levine RA
, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study. PLoS One. 2019; 14(10):e0223472.
PMID:
31600276
.
Citations:
10
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H,
Talkowski ME
, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA,
Ellinor PT
,
Levine RA
, Milan DJ, Schott JJ, Bouatia-Naji N,
Slaugenhaupt SA
, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 05 22; 11(493).
PMID:
31118289
.
Citations:
31
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J,
Ellinor PT
,
Levine RA
,
Slaugenhaupt SA
, Hagège AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 05; 12(5):e002497.
PMID:
31112420
.
Citations:
12
Fields:
Car
Cardiology
Gen
Genetics
Vas
Vascular Diseases
Translation:
Humans
Animals
Kampaktsis PN, Albert BJ, Kim J, Xie LX, Brouwer LR, Tehrani NH, Villanueva M, Choi DY, Szulc M, Ratcliffe MB,
Levine RA
, Devereux RB, Weinsaft JW. Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance-Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing. J Am Heart Assoc. 2019 03 05; 8(5):e010974.
PMID:
30808228
.
Citations:
5
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Schwammenthal E, Hagège AA,
Levine RA
. Does the Flow Know? Mitral Regurgitant Jet Direction and Need for Valve Repair in Hypertrophic Obstructive Cardiomyopathy. J Am Soc Echocardiogr. 2019 03; 32(3):341-343.
PMID:
30827370
.
Citations:
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Chetrit M, Roujol S,
Picard MH
, Timmins L,
Manning WJ
, Rudski LG,
Levine RA
, Afilalo J. Optimal Technique for Measurement of Linear Left Ventricular Dimensions. J Am Soc Echocardiogr. 2019 04; 32(4):476-483.e1.
PMID:
30826223
.
Citations:
4
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Kim J, Alakbarli J, Palumbo MC, Xie LX, Rong LQ, Tehrani NH, Brouwer LR, Devereux RB, Wong SC, Bergman GW, Khalique OK,
Levine RA
, Ratcliffe MB, Weinsaft JW. Left ventricular geometry predicts optimal response to percutaneous mitral repair via MitraClip: Integrated assessment by two- and three-dimensional echocardiography. Catheter Cardiovasc Interv. 2019 05 01; 93(6):1152-1160.
PMID:
30790417
.
Citations:
5
Fields:
Car
Cardiology
Translation:
Humans
Borger MA,
Mansour MC
,
Levine RA
. Atrial Fibrillation and Mitral Valve Prolapse: Time to Intervene? J Am Coll Cardiol. 2019 01 29; 73(3):275-277.
PMID:
30678756
; PMCID:
PMC6581561
.
Citations:
5
Fields:
Car
Cardiology
Translation:
Humans
Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S,
Nagata Y
, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S,
Levine RA
, Otsuji Y. Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis: association with reduced O2 consumption by the whole body. Am J Physiol Heart Circ Physiol. 2019 04 01; 316(4):H840-H848.
PMID:
30681367
; PMCID:
PMC6880195
.
Citations:
2
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Humans
Levine RA
,
Nagata Y
,
Dal-Bianco JP
. Left Ventricular Dyssynchrony and the Mitral Valve Apparatus: An Orchestra That Needs to Play in Sync. JACC Cardiovasc Imaging. 2019 09; 12(9):1738-1740.
PMID:
30660517
.
Citations:
1
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Hei S, Iwataki M, Jang JY, Kuwaki H, Mahara K, Fukuda S, Kim YJ, Nabeshima Y, Onoue T,
Nagata Y
, Nishino S, Watanabe N, Takeuchi M, Nishimura Y, Song JK,
Levine RA
, Otsuji Y. Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H629-H638.
PMID:
30575434
; PMCID:
PMC6459314
.
Citations:
5
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Humans
Kim J, Alakbarli J, Yum B, Tehrani NH, Pollie MP, Abouzeid C, Di Franco A, Ratcliffe MB, Poppas A,
Levine RA
, Devereux RB, Weinsaft JW. Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography. Int J Cardiovasc Imaging. 2019 Apr; 35(4):683-693.
PMID:
30460581
.
Citations:
6
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Toomer K, Sauls K, Fulmer D, Guo L, Moore K, Glover J, Stairley R,
Bischoff J
,
Levine RA
, Norris RA. Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development. Anat Rec (Hoboken). 2019 01; 302(1):117-124.
PMID:
30288957
; PMCID:
PMC6312478
.
Citations:
9
Fields:
Ana
Anatomy
Translation:
Animals
Cells
Groarke JD, Galazka PZ, Cirino AL,
Lakdawala NK
, Thune JJ, Bundgaard H,
Orav EJ
,
Levine RA
,
Ho CY
. Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers. Eur Heart J Cardiovasc Imaging. 2018 10 01; 19(10):1109-1116.
PMID:
30052928
; PMCID:
PMC6148328
.
Citations:
6
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Cells
Athayde GRS, Nascimento BR, Elmariah S, Lodi-Junqueira L, Soares JR, Saad GP, da Silva JLP, Tan TC, Hung J,
Palacios IF
,
Levine RA
, Nunes MCP. Impact of left atrial compliance improvement on functional status after percutaneous mitral valvuloplasty. Catheter Cardiovasc Interv. 2019 01 01; 93(1):156-163.
PMID:
30244517
.
Citations:
2
Fields:
Car
Cardiology
Translation:
Humans
Yoshitani H, Isotani A, Song JK, Shirai S, Umeda H, Jang JY, Onoue T, Toki M, Sun BJ, Kim DH, Kagiyama N, Hayashida A, Song JM, Eto M, Nishimura Y, Ando K, Hanyu M, Yoshida K,
Levine RA
, Otsuji Y. Surgical as Opposed to Transcatheter Aortic Valve Replacement Improves Basal Interventricular Septal Hypertrophy. Circ J. 2018 10 25; 82(11):2887-2895.
PMID:
30135322
; PMCID:
PMC6205894
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
CT
Clinical Trials
Levine RA
,
Jerosch-Herold M
, Hajjar RJ. Mitral Valve Prolapse: A Disease of Valve and Ventricle. J Am Coll Cardiol. 2018 08 21; 72(8):835-837.
PMID:
30115221
; PMCID:
PMC6168064
.
Citations:
7
Fields:
Car
Cardiology
Translation:
Humans
Bartko PE, Pavo N, Pérez-Serradilla A, Arfsten H, Neuhold S, Wurm R, Lang IM, Strunk G,
Dal-Bianco JP
,
Levine RA
, Hülsmann M, Goliasch G. Evolution of secondary mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2018 06 01; 19(6):622-629.
PMID:
29534164
; PMCID:
PMC6458899
.
Citations:
8
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R,
Aikawa E
,
Slaugenhaupt SA
, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN,
Levine RA
, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277.
PMID:
29020406
; PMCID:
PMC5905589
.
Citations:
15
Fields:
Car
Cardiology
Translation:
Humans
Cells
Kim DH,
Dal-Bianco JP
,
Aikawa E
,
Bischoff J
,
Levine RA
. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642.
PMID:
29626080
.
Citations:
1
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Le Tourneau T, Mérot J, Rimbert A, Le Scouarnec S, Probst V, Le Marec H,
Levine RA
, Schott JJ. Genetics of syndromic and non-syndromic mitral valve prolapse. Heart. 2018 06; 104(12):978-984.
PMID:
29352010
; PMCID:
PMC6168077
.
Citations:
13
Fields:
Car
Cardiology
Translation:
Humans
Animals
Kim DH, Morris B, Guerrero JL, Sullivan SM, Hung J,
Levine RA
. Ovine Model of Ischemic Mitral Regurgitation. Methods Mol Biol. 2018; 1816:295-308.
PMID:
29987829
; PMCID:
PMC6207369
.
Citations:
1
Fields:
Mol
Molecular Biology
Translation:
Animals
Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK,
Bischoff J
,
Aikawa E
, Song JM, Kang DH,
Levine RA
, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677.
PMID:
29248661
.
Citations:
17
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Kataoka A,
Zeng X
, Guerrero JL, Kozak A, Braithwaite G,
Levine RA
,
Vlahakes GJ
,
Hung J
. Application of polymer-mesh device to remodel left ventricular-mitral valve apparatus in ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 2018 04; 155(4):1485-1493.
PMID:
29249485
; PMCID:
PMC6237180
.
Citations:
1
Fields:
Car
Cardiology
Gen
General Surgery
Pul
Pulmonary Medicine
Vas
Vascular Diseases
Translation:
Animals
Parwani P, Avierinos JF,
Levine RA
, Delling FN. Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights. Prog Cardiovasc Dis. 2017 Nov - Dec; 60(3):361-369.
PMID:
29122631
; PMCID:
PMC5805573
.
Citations:
7
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Beaudoin J,
Dal-Bianco JP
,
Aikawa E
,
Bischoff J
, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J,
Levine RA
. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11).
PMID:
29042413
.
Citations:
19
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Animals
Di Franco A, Kim J, Rodriguez-Diego S, Khalique O, Siden JY, Goldburg SR, Mehta NK, Srinivasan A, Ratcliffe MB,
Levine RA
, Crea F, Devereux RB, Weinsaft JW. Multiplanar strain quantification for assessment of right ventricular dysfunction and non-ischemic fibrosis among patients with ischemic mitral regurgitation. PLoS One. 2017; 12(9):e0185657.
PMID:
28961271
.
Citations:
6
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Bartko PE,
Dal-Bianco JP
, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A,
Aikawa E
,
Bischoff J
,
Levine RA
. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244.
PMID:
28859786
; PMCID:
PMC5679094
.
Citations:
33
Fields:
Car
Cardiology
Translation:
Humans
Animals
Cells
Nunes MCP, Tan TC, Elmariah S, Lodi-Junqueira L, Nascimento BR, do Lago R, Padilha da Silva JL, Reis RCP, Zeng X,
Palacios IF
, Hung J,
Levine RA
. Net atrioventricular compliance is an independent predictor of cardiovascular death in mitral stenosis. Heart. 2017 12; 103(23):1891-1898.
PMID:
28780580
.
Citations:
6
Fields:
Car
Cardiology
Translation:
Humans
Yang DH, Kim DH, Handschumacher MD,
Levine RA
, Kim JB, Sun BJ, Jang JY, Kim N, Baek S, Kang JW, Song JM, Kang DH, Lim TH, Song JK. In vivo assessment of aortic root geometry in normal controls using 3D analysis of computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 01; 18(7):780-786.
PMID:
27461206
; PMCID:
PMC6279090
.
Citations:
3
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Marsit O, Royer O, Drolet MC, Arsenault M, Couet J, Morin S,
Levine RA
, Pibarot P, Beaudoin J. Early Activation of Growth Pathways in Mitral Leaflets Exposed to Aortic Regurgitation: New Insights from an Animal Model. J Heart Valve Dis. 2017 05; 26(3):281-289.
PMID:
29092112
.
Citations:
1
Fields:
Car
Cardiology
Translation:
Animals
Cells
Bertrand PB, Schwammenthal E,
Levine RA
, Vandervoort PM. Exercise Dynamics in Secondary Mitral Regurgitation: Pathophysiology and Therapeutic Implications. Circulation. 2017 Jan 17; 135(3):297-314.
PMID:
28093494
; PMCID:
PMC5245732
.
Citations:
13
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Hayashi A, Fukuda S, Mahara K, Hei S, Onoue T, Kado Y,
Nagata Y
, Iwataki M, Otani K, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S,
Levine RA
, Otsuji Y. Left Atrial Remodeling in Segmental vs. Global Mitral Valve Prolapse - Three-Dimensional Echocardiography. Circ J. 2016 Nov 25; 80(12):2533-2540.
PMID:
27829586
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Kim J, Di Franco A, Seoane T, Srinivasan A, Kampaktsis PN, Geevarghese A, Goldburg SR, Khan SA, Szulc M, Ratcliffe MB,
Levine RA
, Morgan AE, Maddula P, Rozenstrauch M, Shah T, Devereux RB, Weinsaft JW. Right Ventricular Dysfunction Impairs Effort Tolerance Independent of Left Ventricular Function Among Patients Undergoing Exercise Stress Myocardial Perfusion Imaging. Circ Cardiovasc Imaging. 2016 Nov; 9(11).
PMID:
27903538
.
Citations:
17
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Capoulade R,
Zeng X
, Overbey JR, Ailawadi G, Alexander JH, Ascheim D, Bowdish M, Gelijns AC, Grayburn P, Kron IL,
Levine RA
, Mack MJ,
Melnitchouk S
, Michler RE, Mullen JC,
O'Gara P
, Parides MK, Smith P, Voisine P,
Hung J
. Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty. Circulation. 2016 Oct 25; 134(17):1247-1256.
PMID:
27777294
; PMCID:
PMC5111875
.
Citations:
19
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Bischoff J
, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL,
Dal-Bianco JP
, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS,
Aikawa E
,
Levine RA
. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225.
PMID:
27750208
; PMCID:
PMC5215059
.
Citations:
38
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Pantoja JL, Morgan AE, Grossi EA, Jensen MO, Weinsaft JW,
Levine RA
, Ge L, Ratcliffe MB. Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall. Ann Thorac Surg. 2017 Mar; 103(3):820-827.
PMID:
27720201
; PMCID:
PMC5439528
.
Citations:
2
Fields:
Gen
General Surgery
Pul
Pulmonary Medicine
Translation:
Animals
Fukuda S, Song JK, Mahara K, Kuwaki H, Jang JY, Takeuchi M, Sun BJ, Kim YJ, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S,
Levine RA
, Otsuji Y. Basal Left Ventricular Dilatation and Reduced Contraction in Patients With Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction. Circ Cardiovasc Imaging. 2016 Oct; 9(10).
PMID:
27729364
.
Citations:
10
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Hung J
,
Levine RA
. Pixels or Pixie Dust? Grading of mitral regurgitation using intensity analysis of continuous wave Doppler. Heart. 2017 02; 103(3):177-178.
PMID:
27609944
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Hjortnaes J, Keegan J, Bruneval P, Schwartz E,
Schoen FJ
, Carpentier A,
Levine RA
, Hagège A,
Aikawa E
. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767.
PMID:
28417861
.
Citations:
6
Fields:
Car
Cardiology
Gen
General Surgery
Pul
Pulmonary Medicine
Vas
Vascular Diseases
Translation:
Humans
Cells
Dal-Bianco JP
, Bartko PE,
Levine RA
. The power of ultrasound: treating secondary MR with sound waves. Eur Heart J Cardiovasc Imaging. 2016 10; 17(10):1108-9.
PMID:
27550662
; PMCID:
PMC5031230
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Dal-Bianco JP
, Bartko PE,
Levine RA
. Anticipating the Vicious Circle of Postinfarction Mitral Regurgitation: Imaging Insights. Circ Cardiovasc Imaging. 2016 07; 9(7).
PMID:
27406845
.
Citations:
1
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Beaudoin J,
Singh JP
, Szymonifka J, Zhou Q,
Levine RA
,
Januzzi JL
, Truong QA. Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy-The BIOCRT Study. Can J Cardiol. 2016 12; 32(12):1478-1484.
PMID:
27527259
.
Citations:
4
Fields:
Car
Cardiology
Translation:
Humans
Delling FN, Rong J, Larson MG, Lehman B, Fuller D, Osypiuk E, Stantchev P, Hackman B,
Manning WJ
, Benjamin EJ,
Levine RA
, Vasan RS. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study. Circulation. 2016 Apr 26; 133(17):1688-95.
PMID:
27006478
; PMCID:
PMC4856536
.
Citations:
20
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Dal-Bianco JP
, Bartko PE, Beaudoin J,
Aikawa E
,
Bischoff J
,
Levine RA
. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1.
PMID:
26976355
; PMCID:
PMC4829123
.
Citations:
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Dal-Bianco JP
,
Aikawa E
,
Bischoff J
, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A,
Levine RA
. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87.
PMID:
26796392
; PMCID:
PMC5099077
.
Citations:
35
Fields:
Car
Cardiology
Translation:
Animals
Goyal P, Kim J, Feher A, Ma CL, Gurevich S, Veal DR, Szulc M, Wong FJ, Ratcliffe MB,
Levine RA
, Devereux RB, Weinsaft JW. Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention. Coron Artery Dis. 2015 Dec; 26(8):642-50.
PMID:
26049923
; PMCID:
PMC4631658
.
Citations:
3
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Levine RA
, Hagége AA, Judge DP, Padala M,
Dal-Bianco JP
,
Aikawa E
, Beaudoin J,
Bischoff J
, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E,
Slaugenhaupt SA
, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710.
PMID:
26483167
.
Citations:
95
Fields:
Car
Cardiology
Translation:
Humans
Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P,
Slaugenhaupt SA
, Benjamin EJ,
Levine RA
, Vasan RS. Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community". Circulation. 2015 Oct 06; 132(14):e187-8.
PMID:
26438779
; PMCID:
PMC4620666
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P,
Ellinor PT
, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ,
Slaugenhaupt SA
,
Levine RA
, Schott JJ, Hagege AA, Jeunemaitre X. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct; 47(10):1206-11.
PMID:
26301497
; PMCID:
PMC4773907
.
Citations:
49
Fields:
Gen
Genetics
Translation:
Humans
Animals
Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M,
Talkowski ME
, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A,
Levine RA
, Milan DJ, Norris RA,
Slaugenhaupt SA
. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13.
PMID:
26258302
; PMCID:
PMC4720389
.
Citations:
70
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Blanke P, Dvir D, Cheung A,
Levine RA
, Thompson C, Webb JG, Leipsic J. Mitral Annular Evaluation With CT in the Context of Transcatheter Mitral Valve Replacement. JACC Cardiovasc Imaging. 2015 May; 8(5):612-615.
PMID:
25937198
.
Citations:
24
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JS, Channick RN, Langleben D, Rudski LG, Hua L, Handschumacher MD,
Picard MH
,
Levine RA
. Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension. Circ Cardiovasc Imaging. 2015 May; 8(5).
PMID:
25977303
.
Citations:
9
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Hagège AA, Carpentier A,
Levine RA
. Dynamic changes of the mitral valve annulus: new look at mitral valve diseases. Circ Cardiovasc Imaging. 2015 May; 8(5).
PMID:
25956923
.
Citations:
3
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Judge DP, Neamatalla H, Norris RA,
Levine RA
, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA. Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities. J Cardiovasc Dev Dis. 2015; 2(2):48-65.
PMID:
26819945
; PMCID:
PMC4725593
.
Citations:
5
Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K,
Levine RA
, Hajjar RJ. Reply to "Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions". Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H365-6.
PMID:
25684739
.
Citations:
1
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Animals
Bertrand PB, Verbrugge FH, Verhaert D, Smeets CJ, Grieten L, Mullens W, Gutermann H, Dion RA,
Levine RA
, Vandervoort PM. Mitral valve area during exercise after restrictive mitral valve annuloplasty: importance of diastolic anterior leaflet tethering. J Am Coll Cardiol. 2015 Feb 10; 65(5):452-61.
PMID:
25660923
; PMCID:
PMC4372048
.
Citations:
10
Fields:
Car
Cardiology
Translation:
Humans
Shapero K, Wylie-Sears J,
Levine RA
,
Mayer JE
,
Bischoff J
. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015 Mar; 80:175-85.
PMID:
25633835
; PMCID:
PMC4346432
.
Citations:
31
Fields:
Car
Cardiology
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Dal-Bianco JP
,
Levine RA
. The mitral valve is an actively adapting tissue: new imaging evidence. Eur Heart J Cardiovasc Imaging. 2015 Mar; 16(3):286-7.
PMID:
25617031
.
Citations:
4
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Animals
Zeng X
, Zou L,
Levine RA
, Guerrero JL, Handschumacher MD, Sullivan SM, Braithwaite GJC,
Stone JR
, Solis J,
Muratoglu OK
,
Vlahakes GJ
,
Hung J
. Efficacy of polymer injection for ischemic mitral regurgitation: persistent reduction of mitral regurgitation and attenuation of left ventricular remodeling. JACC Cardiovasc Interv. 2015 Feb; 8(2):355-363.
PMID:
25596792
.
Citations:
2
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Iwataki M, Kim YJ, Sun BJ, Jang JY, Takeuchi M, Fukuda S, Otani K, Yoshitani H, Ohe H, Kohno R, Oginosawa Y, Abe H,
Levine RA
, Song JK, Otsuji Y. Different characteristics of heart failure due to pump failure and bradyarrhythmia. J Echocardiogr. 2015 Mar; 13(1):27-34.
PMID:
25750577
; PMCID:
PMC4346665
.
Citations:
4
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Translation:
Humans
Levine RA
, Schwammenthal E, Song JK. Diastolic leading to systolic anterior motion: new technology reveals physiology. J Am Coll Cardiol. 2014 Nov 11; 64(19):1996-9.
PMID:
25440094
; PMCID:
PMC4373553
.
Citations:
6
Fields:
Car
Cardiology
Translation:
Humans
Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P,
Slaugenhaupt SA
, Benjamin EJ,
Levine RA
, Vasan RS. Familial clustering of mitral valve prolapse in the community. Circulation. 2015 Jan 20; 131(3):263-8.
PMID:
25361552
; PMCID:
PMC4301989
.
Citations:
23
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Blanke P, Dvir D, Cheung A, Ye J,
Levine RA
, Precious B, Berger A, Stub D, Hague C, Murphy D, Thompson C, Munt B, Moss R, Boone R, Wood D, Pache G, Webb J, Leipsic J. A simplified D-shaped model of the mitral annulus to facilitate CT-based sizing before transcatheter mitral valve implantation. J Cardiovasc Comput Tomogr. 2014 Nov-Dec; 8(6):459-67.
PMID:
25467833
.
Citations:
25
Fields:
Car
Cardiology
Rad
Radiology
Vas
Vascular Diseases
Translation:
Humans
Iwataki M, Takeuchi M, Otani K, Kuwaki H, Yoshitani H, Abe H, Lang RM,
Levine RA
, Otsuji Y. Calcific extension towards the mitral valve causes non-rheumatic mitral stenosis in degenerative aortic stenosis: real-time 3D transoesophageal echocardiography study. Open Heart. 2014; 1(1):e000136.
PMID:
25332828
.
Citations:
4
Fields:
Car
Cardiology
Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K,
Levine RA
, Hajjar RJ. Characterizing preclinical models of ischemic heart failure: differences between LAD and LCx infarctions. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1478-86.
PMID:
25217654
.
Citations:
23
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Animals
Kim DH, Handschumacher MD,
Levine RA
, Sun BJ, Jang JY, Yang DH, Kang JW, Song JM, Kang DH, Lim TH, Song JK. Aortic valve adaptation to aortic root dilatation: insights into the mechanism of functional aortic regurgitation from 3-dimensional cardiac computed tomography. Circ Cardiovasc Imaging. 2014 Sep; 7(5):828-35.
PMID:
25051951
.
Citations:
15
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Dal-Bianco JP
, Beaudoin J, Handschumacher MD,
Levine RA
. Basic mechanisms of mitral regurgitation. Can J Cardiol. 2014 Sep; 30(9):971-81.
PMID:
25151282
.
Citations:
23
Fields:
Car
Cardiology
Translation:
Humans
Volo SC, Kim J, Gurevich S, Petashnick M, Kampaktsis P, Feher A, Szulc M, Wong FJ, Devereux RB, Okin PM, Girardi LN, Min JK,
Levine RA
, Weinsaft JW. Effect of myocardial perfusion pattern on frequency and severity of mitral regurgitation in patients with known or suspected coronary artery disease. Am J Cardiol. 2014 Aug 01; 114(3):355-61.
PMID:
24948494
; PMCID:
PMC4157940
.
Citations:
12
Fields:
Car
Cardiology
Translation:
Humans
Nunes MC, Handschumacher MD,
Levine RA
, Barbosa MM, Carvalho VT, Esteves WA,
Zeng X
, Guerrero JL, Zheng H, Tan TC,
Hung J
. Role of LA shape in predicting embolic cerebrovascular events in mitral stenosis: mechanistic insights from 3D echocardiography. JACC Cardiovasc Imaging. 2014 May; 7(5):453-61.
PMID:
24831206
.
Citations:
7
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Wylie-Sears J,
Levine RA
,
Bischoff J
. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-ß-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18; 446(4):870-5.
PMID:
24632204
.
Citations:
31
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Animals
Cells
Yukawa S, Takeuchi M, Nakazono A, Sakamoto K, Araya K, Eto M, Nishimura Y, Harada M,
Levine RA
, Otsuji Y. Mitral stenosis reversed by medical treatment for heart failure. Ann Thorac Surg. 2013 Nov; 96(5):e115-7.
PMID:
24182508
; PMCID:
PMC4281521
.
Citations:
1
Fields:
Gen
General Surgery
Pul
Pulmonary Medicine
Translation:
Humans
Delling FN, Gona P, Larson MG, Lehman B,
Manning WJ
,
Levine RA
, Benjamin EJ, Vasan RS. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum. J Am Soc Echocardiogr. 2014 Jan; 27(1):17-23.
PMID:
24206636
.
Citations:
12
Fields:
Dia
Diagnostic Imaging
Translation:
Humans
Nunes MC, Hung J, Barbosa MM, Esteves WA, Carvalho VT, Lodi-Junqueira L, Fonseca Neto CP, Tan TC,
Levine RA
. Impact of net atrioventricular compliance on clinical outcome in mitral stenosis. Circ Cardiovasc Imaging. 2013 Nov; 6(6):1001-8.
PMID:
24097419
.
Citations:
8
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Beaudoin J,
Levine RA
, Guerrero JL, Yosefy C, Sullivan S, Abedat S, Handschumacher MD, Szymanski C, Gilon D,
Palmeri NO
,
Vlahakes GJ
, Hajjar RJ, Beeri R. Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair. Circulation. 2013 Sep 10; 128(11 Suppl 1):S248-52.
PMID:
24030415
; PMCID:
PMC4281522
.
Citations:
16
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Arokiaraj M, Guerrero L,
Levine R
,
Palacios I
. A theoretical cardiac resynchronization therapy method to augment ventricular contraction using polymer-based actuators and mitral regurgitation reduction with devices over left ventricular endocardial pacing wire--an in-vitro study. J Invasive Cardiol. 2013 Aug; 25(8):415-20.
PMID:
23913609
.
Citations:
Fields:
Car
Cardiology
Translation:
Animals
Beaudoin J, Thai WE, Wai B, Handschumacher MD,
Levine RA
, Truong QA. Assessment of mitral valve adaptation with gated cardiac computed tomography: validation with three-dimensional echocardiography and mechanistic insight to functional mitral regurgitation. Circ Cardiovasc Imaging. 2013 Sep; 6(5):784-9.
PMID:
23873402
.
Citations:
19
Fields:
Car
Cardiology
Dia
Diagnostic Imaging
Vas
Vascular Diseases
Translation:
Humans
Dal-Bianco JP
,
Levine RA
. Anatomy of the mitral valve apparatus: role of 2D and 3D echocardiography. Cardiol Clin. 2013 May; 31(2):151-64.
PMID:
23743068
.
Citations:
25
Fields:
Car