Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Robert A. Levine, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    NIH
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Principal Investigator
  2. R01HL128099 (LEVINE, ROBERT A) Dec 15, 2015 - Nov 30, 2020
    NIH
    Treating Ventricle and Valve: New Synergies for Ischemic LV Remodeling with MR
    Role: Co-Principal Investigator
  3. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2017
    NIH
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Co-Principal Investigator
  4. R21HL072353 (LEVINE, ROBERT A) Sep 30, 2002 - Jul 31, 2006
    NIH
    ACTIVE PATCH THERAPY FOR ISCHEMIC MITRAL REGURGITATION
    Role: Principal Investigator
  5. R01HL072265 (LEVINE, ROBERT A) Mar 15, 2002 - Nov 30, 2014
    NIH
    Effect of Mitral Regurgitation on Ischemic LV Remodeling
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Delling FN, Noseworthy PA, Adams DH, Basso C, Borger M, Bouatia-Naji N, Elmariah S, Evans F, Gerstenfeld E, Hung J, Le Tourneau T, Lewis J, Miller MA, Norris RA, Padala M, Perazzolo-Marra M, Shah DJ, Weinsaft JW, Enriquez-Sarano M, Levine RA. Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel. J Am Coll Cardiol. 2022 Dec 13; 80(24):2331-2347. PMID: 36480975.
    Citations:    Fields:    
  2. Marsit O, Levine RA, Beaudoin J. Reply: Another Road to Rome: Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2022 12 06; 80(23):e215. PMID: 36456057.
    Citations:    Fields:    
  3. Zoghbi WA, Levine RA, Flachskampf F, Grayburn P, Gillam L, Leipsic J, Thomas JD, Kwong RY, Vandervoort P, Chandrashekhar Y. Atrial Functional Mitral Regurgitation: A JACC: Cardiovascular Imaging Expert Panel Viewpoint. JACC Cardiovasc Imaging. 2022 11; 15(11):1870-1882. PMID: 36357130.
    Citations:    Fields:    Translation:Humans
  4. Rosalia L, Ozturk C, Coll-Font J, Fan Y, Nagata Y, Singh M, Goswami D, Mauskapf A, Chen S, Eder RA, Goffer EM, Kim JH, Yurista S, Bonner BP, Foster AN, Levine RA, Edelman ER, Panagia M, Guerrero JL, Roche ET, Nguyen CT. A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis. Nat Biomed Eng. 2022 10; 6(10):1134-1147. PMID: 36163494; PMCID: PMC9588718.
    Citations:    Fields:    Translation:Animals
  5. Churchill TW, Yucel E, Deferm S, Levine RA, Hung J, Bertrand PB. Mitral Valve Dysfunction in Patients With Annular Calcification: JACC Review Topic of the Week. J Am Coll Cardiol. 2022 08 16; 80(7):739-751. PMID: 35953139.
    Citations:    Fields:    Translation:Humans
  6. Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J. Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2022 08 02; 80(5):500-510. PMID: 35902173.
    Citations:    Fields:    
  7. Passos LSA, Nizet V, Levine RA, Aikawa E. Can we diagnose acute rheumatic fever early to maximize the success of secondary prophylaxis in rheumatic heart valve disease? Cardiovasc Res. 2022 07 20; 118(9):e62-e65. PMID: 35862716.
    Citations:    Fields:    Translation:HumansPHPublic Health
  8. Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J. Progression of aortic stenosis after an acute myocardial infarction. Open Heart. 2022 06; 9(1). PMID: 35728891; PMCID: PMC9214429.
    Citations:    Fields:    Translation:HumansAnimals
  9. Kochav JD, Kim J, Judd R, Tak KA, Janjua E, Maciejewski AJ, Kim HW, Klem I, Heitner J, Shah D, Zoghbi WA, Shenoy C, Farzaneh-Far A, Polsani V, Villar-Calle P, Parker M, Judd KM, Khalique OK, Leon MB, Devereux RB, Levine RA, Kim RJ, Weinsaft JW. Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance. JACC Cardiovasc Imaging. 2022 07; 15(7):1212-1226. PMID: 35798397; PMCID: PMC9273017.
    Citations:    Fields:    Translation:Humans
  10. Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, Weng LC, Delling FN, Maurya SR, Schrölkamp M, Tfelt-Hansen J, Hagège A, Jeunemaitre X, Debette S, Amouyel P, Guan W, Muehlschlegel JD, Body SC, Shah S, Samad Z, Kyryachenko S, Haynes C, Rienstra M, Le Tourneau T, Probst V, Roussel R, Wijdh-Den Hamer IJ, Siland JE, Knowlton KU, Jacques Schott J, Levine RA, Benjamin EJ, Vasan RS, Horne BD, Muhlestein JB, Benfari G, Enriquez-Sarano M, Natale A, Mohanty S, Trivedi C, Shoemaker MB, Yoneda ZT, Wells QS, Baker MT, Farber-Eger E, Michelena HI, Lundby A, Norris RA, Slaugenhaupt SA, Dina C, Lubitz SA, Bouatia-Naji N, Ellinor PT, Milan DJ. Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse. Eur Heart J. 2022 05 01; 43(17):1668-1680. PMID: 35245370; PMCID: PMC9649914.
    Citations: 2     Fields:    Translation:Humans
  11. Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J. Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. J Am Heart Assoc. 2022 04 05; 11(7):e023695. PMID: 35348006; PMCID: PMC9075477.
    Citations:    Fields:    Translation:AnimalsCells
  12. Nagata Y, Bertrand PB, Levine RA. Malignant Mitral Valve Prolapse: Risk and Prevention of Sudden Cardiac Death. Curr Treat Options Cardiovasc Med. 2022 May; 24(5):61-86. PMID: 35784809; PMCID: PMC9241643.
    Citations:    
  13. Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP. Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling. Front Cardiovasc Med. 2022; 9:862382. PMID: 35360029; PMCID: PMC8962951.
    Citations:    
  14. Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E. Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. Circulation. 2022 02 15; 145(7):531-548. PMID: 35157519; PMCID: PMC8869797.
    Citations: 2     Fields:    Translation:HumansCells
  15. Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia LG, Dal-Bianco JP, Levine RA, Aikawa M, Hung J, Dutra WO, Nunes MCP, Aikawa E. Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty. Front Cardiovasc Med. 2021; 8:804111. PMID: 35127864; PMCID: PMC8811173.
    Citations: 1     
  16. Deferm S, Bertrand PB, Yucel E, Bernard S, Namasivayam M, Nagata Y, Dal-Bianco JP, Sanborn DY, Picard MH, Levine RA, Hung J, Churchill TW. Impact of Pulmonary Hypertension on Outcomes in Patients With Mitral Annular Calcium and Associated Mitral Valve Dysfunction. Am J Cardiol. 2022 03 15; 167:76-82. PMID: 34991846.
    Citations:    Fields:    Translation:Humans
  17. Morningstar JE, Gensemer C, Moore R, Fulmer D, Beck TC, Wang C, Moore K, Guo L, Sieg F, Nagata Y, Bertrand P, Spampinato RA, Glover J, Poelzing S, Gourdie RG, Watts K, Richardson WJ, Levine RA, Borger MA, Norris RA. Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis. J Am Heart Assoc. 2021 12 21; 10(24):e022332. PMID: 34873924; PMCID: PMC9075228.
    Citations: 1     Fields:    Translation:HumansAnimals
  18. Rong LQ, Lopes AJ, Mitlak HW, Palumbo MC, Mick S, Kim J, Levine RA, Wong SC, Reisman M, Devereux RB, Gaudino M, Weinsaft JW. Relative Impact of Surgical Mitral Repair and MitraClip on Annular Remodeling-A Potential Mechanism for Therapeutic Response to Mitral Repair for Degenerative Mitral Regurgitation. J Cardiothorac Vasc Anesth. 2022 05; 36(5):1279-1287. PMID: 34600832; PMCID: PMC9027699.
    Citations:    Fields:    Translation:Humans
  19. Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E. Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients. Front Cardiovasc Med. 2021; 8:688396. PMID: 34458332; PMCID: PMC8387660.
    Citations:    
  20. Deferm S, Bertrand PB, Verhaert D, Verbrugge FH, Dauw J, Thoelen K, Giesen A, Bruckers L, Rega F, Thomas JD, Levine RA, Vandervoort PM. Mitral Annular Dynamics in AF Versus Sinus Rhythm: Novel Insights Into the Mechanism of AFMR. JACC Cardiovasc Imaging. 2022 01; 15(1):1-13. PMID: 34274270.
    Citations:    Fields:    Translation:Humans
  21. Levine RA, Nagata Y. Imaging Cardiac Valve Mechanics: A New Frontier. JACC Cardiovasc Imaging. 2021 04; 14(4):794-796. PMID: 33832662.
    Citations:    Fields:    Translation:Humans
  22. Kochav JD, Kim J, Judd R, Kim HW, Klem I, Heitner J, Shah D, Shenoy C, Farzaneh-Far A, Polsani V, Kalil R, Villar-Calle P, Nambiar L, Sultana R, Parker M, Cargile P, Khalique OK, Leon MB, Karmpaliotis D, Ratcliffe M, Levine R, Zoghbi WA, Devereux RB, Moskowitz CS, Kim R, Weinsaft JW. Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2021 04; 14(4):826-839. PMID: 33744130; PMCID: PMC8086776.
    Citations: 2     Fields:    Translation:Humans
  23. Bertrand PB, Overbey JR, Zeng X, Levine RA, Ailawadi G, Acker MA, Smith PK, Thourani VH, Bagiella E, Miller MA, Gupta L, Mack MJ, Gillinov AM, Giustino G, Moskowitz AJ, Gelijns AC, Bowdish ME, O'Gara PT, Gammie JS, Hung J. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2021 02 16; 77(6):713-724. PMID: 33573741; PMCID: PMC7953587.
    Citations:    Fields:    Translation:Humans
  24. Dal-Bianco JP, Levine RA, Hung J. Mitral Regurgitation Postinfarction: The Mitral Valve Adapts to the Times. Circ Cardiovasc Imaging. 2020 12; 13(12):e012130. PMID: 33317331.
    Citations:    Fields:    Translation:Humans
  25. Bertrand PB, Churchill TW, Yucel E, Namasivayam M, Bernard S, Nagata Y, He W, Andrews CT, Picard MH, Weyman AE, Levine RA, Hung J. Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction. Eur Heart J. 2020 12 01; 41(45):4321-4328. PMID: 33221855.
    Citations: 3     Fields:    Translation:Humans
  26. Onoue T, Iwataki M, Araki M, Akashi J, Kitano T, Nabeshima Y, Hei S, Nagata Y, Hayashi A, Tsuda Y, Sonoda S, Fujino Y, Levine RA, Otsuji Y. Novel noninvasive estimation of mixed venous oxygen saturation by echocardiography and expired gas analysis. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H1078-H1086. PMID: 32946269.
    Citations: 1     Fields:    Translation:Humans
  27. Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J. Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes. JACC Cardiovasc Imaging. 2020 12; 13(12):2513-2526. PMID: 32950446.
    Citations: 2     Fields:    Translation:Humans
  28. Bertrand PB, Nagata Y, Namasivayam M, Levine RA. The Artifact that Tells the Truth: Color Doppler Splay Unmasking Significant Mitral Regurgitation. J Am Soc Echocardiogr. 2020 10; 33(10):1220-1222. PMID: 32855003.
    Citations:    Fields:    Translation:Humans
  29. Kim J, Yum B, Palumbo MC, Sultana R, Wright N, Das M, You C, Moskowitz CS, Levine RA, Devereux RB, Weinsaft JW. Left Atrial Strain Impairment Precedes Geometric Remodeling as a Marker of Post-Myocardial Infarction Diastolic Dysfunction. JACC Cardiovasc Imaging. 2020 10; 13(10):2099-2113. PMID: 32828776.
    Citations: 8     Fields:    Translation:Humans
  30. Nagata Y, Iwataki M, Nabeshima Y, Hei S, Onoue T, Hayashi A, Otani K, Tsuda Y, Araki M, Kim DH, Song JK, Hayashida A, Toki M, Yuasa T, Mizukami N, Nishimura Y, Levine RA, Otsuji Y. Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H694-H704. PMID: 32795182.
    Citations: 1     Fields:    Translation:Humans
  31. Bartko PE, Hülsmann M, Hung J, Pavo N, Levine RA, Pibarot P, Vahanian A, Stone GW, Goliasch G. Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction. Eur Heart J. 2020 08 01; 41(29):2799-2810. PMID: 32350503; PMCID: PMC8453270.
    Citations: 8     Fields:    Translation:Humans
  32. Namasivayam M, He W, Churchill TW, Capoulade R, Liu S, Lee H, Danik JS, Picard MH, Pibarot P, Levine RA, Hung J. Transvalvular Flow Rate Determines Prognostic Value of Aortic Valve Area in Aortic Stenosis. J Am Coll Cardiol. 2020 04 21; 75(15):1758-1769. PMID: 32299587; PMCID: PMC8087111.
    Citations: 10     Fields:    Translation:Humans
  33. Liu S, Churchill J, Hua L, Zeng X, Rhoades V, Namasivayam M, Baliyan V, Ghoshhajra BB, Dong T, Dal-Bianco JP, Passeri JJ, Levine RA, Hung J. Direct Planimetry of Left Ventricular Outflow Tract Area by Simultaneous Biplane Imaging: Challenging the Need for a Circular Assumption of the Left Ventricular Outflow Tract in the Assessment of Aortic Stenosis. J Am Soc Echocardiogr. 2020 04; 33(4):461-468. PMID: 32248906.
    Citations:    Fields:    Translation:Humans
  34. Yang LT, Ahn SW, Li Z, Benfari G, Mankad R, Takeuchi M, Levine RA, Enriquez-Sarano M, Michelena HI. Mitral Valve Prolapse Patients with Less than Moderate Mitral Regurgitation Exhibit Early Cardiac Chamber Remodeling. J Am Soc Echocardiogr. 2020 07; 33(7):815-825.e2. PMID: 32222479.
    Citations: 3     Fields:    Translation:Humans
  35. Cristina de Castro Faria S, Costa HS, Hung J, Gorle de Miranda Chaves A, Paes de Oliveira FA, Padilha da Silva JL, Esteves WAM, Tan TC, Levine RA, Pereira Nunes MC. Pulmonary Artery Systolic Pressure Response to Exercise in Patients with Rheumatic Mitral Stenosis: Determinants and Prognostic Value. J Am Soc Echocardiogr. 2020 05; 33(5):550-558. PMID: 32127221.
    Citations:    Fields:    Translation:Humans
  36. Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2020 02 04; 75(4):395-405. PMID: 32000951; PMCID: PMC7946170.
    Citations: 4     Fields:    Translation:AnimalsCells
  37. Hei S, Iwataki M, Jang JY, Kuwaki H, Fukuda S, Kim YJ, Toki M, Onoue T, Hayashi A, Nishino S, Watanabe N, Hayashida A, Tsuda Y, Araki M, Nishimura Y, Song JK, Yoshida K, Levine RA, Otsuji Y. Relations of Augmented Systolic Annular Expansion and Leaflet/Papillary Muscle Dynamics in Late-Systolic Mitral Valve Prolapse Evaluated by Echocardiography with a Speckle Tracking Analysis. Int Heart J. 2020; 61(5):970-978. PMID: 32999196.
    Citations:    Fields:    Translation:Humans
  38. Kim J, Palumbo MC, Khalique OK, Rong LQ, Sultana R, Das M, Jantz J, Nagata Y, Devereux RB, Wong SC, Bergman GW, Levine RA, Ratcliffe MB, Weinsaft JW. Transcatheter MitraClip repair alters mitral annular geometry - device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response. Cardiovasc Ultrasound. 2019 Dec 26; 17(1):31. PMID: 31878931; PMCID: PMC6933704.
    Citations: 3     Fields:    Translation:Humans
  39. Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study. PLoS One. 2019; 14(10):e0223472. PMID: 31600276.
    Citations: 10     Fields:    Translation:Animals
  40. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 05 22; 11(493). PMID: 31118289.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  41. Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J, Ellinor PT, Levine RA, Slaugenhaupt SA, Hagège AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 05; 12(5):e002497. PMID: 31112420.
    Citations: 12     Fields:    Translation:HumansAnimals
  42. Kampaktsis PN, Albert BJ, Kim J, Xie LX, Brouwer LR, Tehrani NH, Villanueva M, Choi DY, Szulc M, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW. Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance-Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing. J Am Heart Assoc. 2019 03 05; 8(5):e010974. PMID: 30808228.
    Citations: 5     Fields:    Translation:Humans
  43. Schwammenthal E, Hagège AA, Levine RA. Does the Flow Know? Mitral Regurgitant Jet Direction and Need for Valve Repair in Hypertrophic Obstructive Cardiomyopathy. J Am Soc Echocardiogr. 2019 03; 32(3):341-343. PMID: 30827370.
    Citations:    Fields:    Translation:Humans
  44. Chetrit M, Roujol S, Picard MH, Timmins L, Manning WJ, Rudski LG, Levine RA, Afilalo J. Optimal Technique for Measurement of Linear Left Ventricular Dimensions. J Am Soc Echocardiogr. 2019 04; 32(4):476-483.e1. PMID: 30826223.
    Citations: 4     Fields:    Translation:Humans
  45. Kim J, Alakbarli J, Palumbo MC, Xie LX, Rong LQ, Tehrani NH, Brouwer LR, Devereux RB, Wong SC, Bergman GW, Khalique OK, Levine RA, Ratcliffe MB, Weinsaft JW. Left ventricular geometry predicts optimal response to percutaneous mitral repair via MitraClip: Integrated assessment by two- and three-dimensional echocardiography. Catheter Cardiovasc Interv. 2019 05 01; 93(6):1152-1160. PMID: 30790417.
    Citations: 5     Fields:    Translation:Humans
  46. Borger MA, Mansour MC, Levine RA. Atrial Fibrillation and Mitral Valve Prolapse: Time to Intervene? J Am Coll Cardiol. 2019 01 29; 73(3):275-277. PMID: 30678756; PMCID: PMC6581561.
    Citations: 5     Fields:    Translation:Humans
  47. Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S, Nagata Y, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S, Levine RA, Otsuji Y. Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis: association with reduced O2 consumption by the whole body. Am J Physiol Heart Circ Physiol. 2019 04 01; 316(4):H840-H848. PMID: 30681367; PMCID: PMC6880195.
    Citations: 2     Fields:    Translation:Humans
  48. Levine RA, Nagata Y, Dal-Bianco JP. Left Ventricular Dyssynchrony and the Mitral Valve Apparatus: An Orchestra That Needs to Play in Sync. JACC Cardiovasc Imaging. 2019 09; 12(9):1738-1740. PMID: 30660517.
    Citations: 1     Fields:    Translation:Humans
  49. Hei S, Iwataki M, Jang JY, Kuwaki H, Mahara K, Fukuda S, Kim YJ, Nabeshima Y, Onoue T, Nagata Y, Nishino S, Watanabe N, Takeuchi M, Nishimura Y, Song JK, Levine RA, Otsuji Y. Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H629-H638. PMID: 30575434; PMCID: PMC6459314.
    Citations: 5     Fields:    Translation:Humans
  50. Kim J, Alakbarli J, Yum B, Tehrani NH, Pollie MP, Abouzeid C, Di Franco A, Ratcliffe MB, Poppas A, Levine RA, Devereux RB, Weinsaft JW. Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography. Int J Cardiovasc Imaging. 2019 Apr; 35(4):683-693. PMID: 30460581.
    Citations: 6     Fields:    Translation:Humans
  51. Toomer K, Sauls K, Fulmer D, Guo L, Moore K, Glover J, Stairley R, Bischoff J, Levine RA, Norris RA. Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development. Anat Rec (Hoboken). 2019 01; 302(1):117-124. PMID: 30288957; PMCID: PMC6312478.
    Citations: 9     Fields:    Translation:AnimalsCells
  52. Groarke JD, Galazka PZ, Cirino AL, Lakdawala NK, Thune JJ, Bundgaard H, Orav EJ, Levine RA, Ho CY. Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers. Eur Heart J Cardiovasc Imaging. 2018 10 01; 19(10):1109-1116. PMID: 30052928; PMCID: PMC6148328.
    Citations: 6     Fields:    Translation:HumansCells
  53. Athayde GRS, Nascimento BR, Elmariah S, Lodi-Junqueira L, Soares JR, Saad GP, da Silva JLP, Tan TC, Hung J, Palacios IF, Levine RA, Nunes MCP. Impact of left atrial compliance improvement on functional status after percutaneous mitral valvuloplasty. Catheter Cardiovasc Interv. 2019 01 01; 93(1):156-163. PMID: 30244517.
    Citations: 2     Fields:    Translation:Humans
  54. Yoshitani H, Isotani A, Song JK, Shirai S, Umeda H, Jang JY, Onoue T, Toki M, Sun BJ, Kim DH, Kagiyama N, Hayashida A, Song JM, Eto M, Nishimura Y, Ando K, Hanyu M, Yoshida K, Levine RA, Otsuji Y. Surgical as Opposed to Transcatheter Aortic Valve Replacement Improves Basal Interventricular Septal Hypertrophy. Circ J. 2018 10 25; 82(11):2887-2895. PMID: 30135322; PMCID: PMC6205894.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  55. Levine RA, Jerosch-Herold M, Hajjar RJ. Mitral Valve Prolapse: A Disease of Valve and Ventricle. J Am Coll Cardiol. 2018 08 21; 72(8):835-837. PMID: 30115221; PMCID: PMC6168064.
    Citations: 7     Fields:    Translation:Humans
  56. Bartko PE, Pavo N, Pérez-Serradilla A, Arfsten H, Neuhold S, Wurm R, Lang IM, Strunk G, Dal-Bianco JP, Levine RA, Hülsmann M, Goliasch G. Evolution of secondary mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2018 06 01; 19(6):622-629. PMID: 29534164; PMCID: PMC6458899.
    Citations: 8     Fields:    Translation:Humans
  57. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277. PMID: 29020406; PMCID: PMC5905589.
    Citations: 15     Fields:    Translation:HumansCells
  58. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642. PMID: 29626080.
    Citations: 1     Fields:    Translation:Humans
  59. Le Tourneau T, Mérot J, Rimbert A, Le Scouarnec S, Probst V, Le Marec H, Levine RA, Schott JJ. Genetics of syndromic and non-syndromic mitral valve prolapse. Heart. 2018 06; 104(12):978-984. PMID: 29352010; PMCID: PMC6168077.
    Citations: 13     Fields:    Translation:HumansAnimals
  60. Kim DH, Morris B, Guerrero JL, Sullivan SM, Hung J, Levine RA. Ovine Model of Ischemic Mitral Regurgitation. Methods Mol Biol. 2018; 1816:295-308. PMID: 29987829; PMCID: PMC6207369.
    Citations: 1     Fields:    Translation:Animals
  61. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677. PMID: 29248661.
    Citations: 17     Fields:    Translation:Humans
  62. Kataoka A, Zeng X, Guerrero JL, Kozak A, Braithwaite G, Levine RA, Vlahakes GJ, Hung J. Application of polymer-mesh device to remodel left ventricular-mitral valve apparatus in ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 2018 04; 155(4):1485-1493. PMID: 29249485; PMCID: PMC6237180.
    Citations: 1     Fields:    Translation:Animals
  63. Parwani P, Avierinos JF, Levine RA, Delling FN. Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights. Prog Cardiovasc Dis. 2017 Nov - Dec; 60(3):361-369. PMID: 29122631; PMCID: PMC5805573.
    Citations: 7     Fields:    Translation:Humans
  64. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 19     Fields:    Translation:HumansAnimals
  65. Di Franco A, Kim J, Rodriguez-Diego S, Khalique O, Siden JY, Goldburg SR, Mehta NK, Srinivasan A, Ratcliffe MB, Levine RA, Crea F, Devereux RB, Weinsaft JW. Multiplanar strain quantification for assessment of right ventricular dysfunction and non-ischemic fibrosis among patients with ischemic mitral regurgitation. PLoS One. 2017; 12(9):e0185657. PMID: 28961271.
    Citations: 6     Fields:    Translation:Humans
  66. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786; PMCID: PMC5679094.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  67. Nunes MCP, Tan TC, Elmariah S, Lodi-Junqueira L, Nascimento BR, do Lago R, Padilha da Silva JL, Reis RCP, Zeng X, Palacios IF, Hung J, Levine RA. Net atrioventricular compliance is an independent predictor of cardiovascular death in mitral stenosis. Heart. 2017 12; 103(23):1891-1898. PMID: 28780580.
    Citations: 6     Fields:    Translation:Humans
  68. Yang DH, Kim DH, Handschumacher MD, Levine RA, Kim JB, Sun BJ, Jang JY, Kim N, Baek S, Kang JW, Song JM, Kang DH, Lim TH, Song JK. In vivo assessment of aortic root geometry in normal controls using 3D analysis of computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 01; 18(7):780-786. PMID: 27461206; PMCID: PMC6279090.
    Citations: 3     Fields:    Translation:Humans
  69. Marsit O, Royer O, Drolet MC, Arsenault M, Couet J, Morin S, Levine RA, Pibarot P, Beaudoin J. Early Activation of Growth Pathways in Mitral Leaflets Exposed to Aortic Regurgitation: New Insights from an Animal Model. J Heart Valve Dis. 2017 05; 26(3):281-289. PMID: 29092112.
    Citations: 1     Fields:    Translation:AnimalsCells
  70. Bertrand PB, Schwammenthal E, Levine RA, Vandervoort PM. Exercise Dynamics in Secondary Mitral Regurgitation: Pathophysiology and Therapeutic Implications. Circulation. 2017 Jan 17; 135(3):297-314. PMID: 28093494; PMCID: PMC5245732.
    Citations: 13     Fields:    Translation:Humans
  71. Hayashi A, Fukuda S, Mahara K, Hei S, Onoue T, Kado Y, Nagata Y, Iwataki M, Otani K, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Left Atrial Remodeling in Segmental vs. Global Mitral Valve Prolapse - Three-Dimensional Echocardiography. Circ J. 2016 Nov 25; 80(12):2533-2540. PMID: 27829586.
    Citations: 1     Fields:    Translation:Humans
  72. Kim J, Di Franco A, Seoane T, Srinivasan A, Kampaktsis PN, Geevarghese A, Goldburg SR, Khan SA, Szulc M, Ratcliffe MB, Levine RA, Morgan AE, Maddula P, Rozenstrauch M, Shah T, Devereux RB, Weinsaft JW. Right Ventricular Dysfunction Impairs Effort Tolerance Independent of Left Ventricular Function Among Patients Undergoing Exercise Stress Myocardial Perfusion Imaging. Circ Cardiovasc Imaging. 2016 Nov; 9(11). PMID: 27903538.
    Citations: 17     Fields:    Translation:Humans
  73. Capoulade R, Zeng X, Overbey JR, Ailawadi G, Alexander JH, Ascheim D, Bowdish M, Gelijns AC, Grayburn P, Kron IL, Levine RA, Mack MJ, Melnitchouk S, Michler RE, Mullen JC, O'Gara P, Parides MK, Smith P, Voisine P, Hung J. Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty. Circulation. 2016 Oct 25; 134(17):1247-1256. PMID: 27777294; PMCID: PMC5111875.
    Citations: 19     Fields:    Translation:Humans
  74. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208; PMCID: PMC5215059.
    Citations: 38     Fields:    Translation:AnimalsCells
  75. Pantoja JL, Morgan AE, Grossi EA, Jensen MO, Weinsaft JW, Levine RA, Ge L, Ratcliffe MB. Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall. Ann Thorac Surg. 2017 Mar; 103(3):820-827. PMID: 27720201; PMCID: PMC5439528.
    Citations: 2     Fields:    Translation:Animals
  76. Fukuda S, Song JK, Mahara K, Kuwaki H, Jang JY, Takeuchi M, Sun BJ, Kim YJ, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Basal Left Ventricular Dilatation and Reduced Contraction in Patients With Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction. Circ Cardiovasc Imaging. 2016 Oct; 9(10). PMID: 27729364.
    Citations: 10     Fields:    Translation:Humans
  77. Hung J, Levine RA. Pixels or Pixie Dust? Grading of mitral regurgitation using intensity analysis of continuous wave Doppler. Heart. 2017 02; 103(3):177-178. PMID: 27609944.
    Citations:    Fields:    Translation:Humans
  78. Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767. PMID: 28417861.
    Citations: 6     Fields:    Translation:HumansCells
  79. Dal-Bianco JP, Bartko PE, Levine RA. The power of ultrasound: treating secondary MR with sound waves. Eur Heart J Cardiovasc Imaging. 2016 10; 17(10):1108-9. PMID: 27550662; PMCID: PMC5031230.
    Citations:    Fields:    Translation:Humans
  80. Dal-Bianco JP, Bartko PE, Levine RA. Anticipating the Vicious Circle of Postinfarction Mitral Regurgitation: Imaging Insights. Circ Cardiovasc Imaging. 2016 07; 9(7). PMID: 27406845.
    Citations: 1     Fields:    Translation:Humans
  81. Beaudoin J, Singh JP, Szymonifka J, Zhou Q, Levine RA, Januzzi JL, Truong QA. Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy-The BIOCRT Study. Can J Cardiol. 2016 12; 32(12):1478-1484. PMID: 27527259.
    Citations: 4     Fields:    Translation:Humans
  82. Delling FN, Rong J, Larson MG, Lehman B, Fuller D, Osypiuk E, Stantchev P, Hackman B, Manning WJ, Benjamin EJ, Levine RA, Vasan RS. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study. Circulation. 2016 Apr 26; 133(17):1688-95. PMID: 27006478; PMCID: PMC4856536.
    Citations: 20     Fields:    Translation:Humans
  83. Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1. PMID: 26976355; PMCID: PMC4829123.
    Citations:    Fields:    Translation:Humans
  84. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87. PMID: 26796392; PMCID: PMC5099077.
    Citations: 35     Fields:    Translation:Animals
  85. Goyal P, Kim J, Feher A, Ma CL, Gurevich S, Veal DR, Szulc M, Wong FJ, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW. Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention. Coron Artery Dis. 2015 Dec; 26(8):642-50. PMID: 26049923; PMCID: PMC4631658.
    Citations: 3     Fields:    Translation:Humans
  86. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
    Citations: 95     Fields:    Translation:Humans
  87. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community". Circulation. 2015 Oct 06; 132(14):e187-8. PMID: 26438779; PMCID: PMC4620666.
    Citations:    Fields:    Translation:Humans
  88. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Jeunemaitre X. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct; 47(10):1206-11. PMID: 26301497; PMCID: PMC4773907.
    Citations: 49     Fields:    Translation:HumansAnimals
  89. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302; PMCID: PMC4720389.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  90. Blanke P, Dvir D, Cheung A, Levine RA, Thompson C, Webb JG, Leipsic J. Mitral Annular Evaluation With CT in the Context of Transcatheter Mitral Valve Replacement. JACC Cardiovasc Imaging. 2015 May; 8(5):612-615. PMID: 25937198.
    Citations: 24     Fields:    Translation:Humans
  91. Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JS, Channick RN, Langleben D, Rudski LG, Hua L, Handschumacher MD, Picard MH, Levine RA. Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension. Circ Cardiovasc Imaging. 2015 May; 8(5). PMID: 25977303.
    Citations: 9     Fields:    Translation:Humans
  92. Hagège AA, Carpentier A, Levine RA. Dynamic changes of the mitral valve annulus: new look at mitral valve diseases. Circ Cardiovasc Imaging. 2015 May; 8(5). PMID: 25956923.
    Citations: 3     Fields:    Translation:Humans
  93. Judge DP, Neamatalla H, Norris RA, Levine RA, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA. Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities. J Cardiovasc Dev Dis. 2015; 2(2):48-65. PMID: 26819945; PMCID: PMC4725593.
    Citations: 5     
  94. Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ. Reply to "Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions". Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H365-6. PMID: 25684739.
    Citations: 1     Fields:    Translation:Animals
  95. Bertrand PB, Verbrugge FH, Verhaert D, Smeets CJ, Grieten L, Mullens W, Gutermann H, Dion RA, Levine RA, Vandervoort PM. Mitral valve area during exercise after restrictive mitral valve annuloplasty: importance of diastolic anterior leaflet tethering. J Am Coll Cardiol. 2015 Feb 10; 65(5):452-61. PMID: 25660923; PMCID: PMC4372048.
    Citations: 10     Fields:    Translation:Humans
  96. Shapero K, Wylie-Sears J, Levine RA, Mayer JE, Bischoff J. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015 Mar; 80:175-85. PMID: 25633835; PMCID: PMC4346432.
    Citations: 31     Fields:    Translation:AnimalsCells
  97. Dal-Bianco JP, Levine RA. The mitral valve is an actively adapting tissue: new imaging evidence. Eur Heart J Cardiovasc Imaging. 2015 Mar; 16(3):286-7. PMID: 25617031.
    Citations: 4     Fields:    Translation:HumansAnimals
  98. Zeng X, Zou L, Levine RA, Guerrero JL, Handschumacher MD, Sullivan SM, Braithwaite GJC, Stone JR, Solis J, Muratoglu OK, Vlahakes GJ, Hung J. Efficacy of polymer injection for ischemic mitral regurgitation: persistent reduction of mitral regurgitation and attenuation of left ventricular remodeling. JACC Cardiovasc Interv. 2015 Feb; 8(2):355-363. PMID: 25596792.
    Citations: 2     Fields:    Translation:Animals
  99. Iwataki M, Kim YJ, Sun BJ, Jang JY, Takeuchi M, Fukuda S, Otani K, Yoshitani H, Ohe H, Kohno R, Oginosawa Y, Abe H, Levine RA, Song JK, Otsuji Y. Different characteristics of heart failure due to pump failure and bradyarrhythmia. J Echocardiogr. 2015 Mar; 13(1):27-34. PMID: 25750577; PMCID: PMC4346665.
    Citations: 4     Fields:    Translation:Humans
  100. Levine RA, Schwammenthal E, Song JK. Diastolic leading to systolic anterior motion: new technology reveals physiology. J Am Coll Cardiol. 2014 Nov 11; 64(19):1996-9. PMID: 25440094; PMCID: PMC4373553.
    Citations: 6     Fields:    Translation:Humans
  101. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Familial clustering of mitral valve prolapse in the community. Circulation. 2015 Jan 20; 131(3):263-8. PMID: 25361552; PMCID: PMC4301989.
    Citations: 23     Fields:    Translation:Humans
  102. Blanke P, Dvir D, Cheung A, Ye J, Levine RA, Precious B, Berger A, Stub D, Hague C, Murphy D, Thompson C, Munt B, Moss R, Boone R, Wood D, Pache G, Webb J, Leipsic J. A simplified D-shaped model of the mitral annulus to facilitate CT-based sizing before transcatheter mitral valve implantation. J Cardiovasc Comput Tomogr. 2014 Nov-Dec; 8(6):459-67. PMID: 25467833.
    Citations: 25     Fields:    Translation:Humans
  103. Iwataki M, Takeuchi M, Otani K, Kuwaki H, Yoshitani H, Abe H, Lang RM, Levine RA, Otsuji Y. Calcific extension towards the mitral valve causes non-rheumatic mitral stenosis in degenerative aortic stenosis: real-time 3D transoesophageal echocardiography study. Open Heart. 2014; 1(1):e000136. PMID: 25332828.
    Citations: 4     Fields:    
  104. Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ. Characterizing preclinical models of ischemic heart failure: differences between LAD and LCx infarctions. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1478-86. PMID: 25217654.
    Citations: 23     Fields:    Translation:Animals
  105. Kim DH, Handschumacher MD, Levine RA, Sun BJ, Jang JY, Yang DH, Kang JW, Song JM, Kang DH, Lim TH, Song JK. Aortic valve adaptation to aortic root dilatation: insights into the mechanism of functional aortic regurgitation from 3-dimensional cardiac computed tomography. Circ Cardiovasc Imaging. 2014 Sep; 7(5):828-35. PMID: 25051951.
    Citations: 15     Fields:    Translation:Humans
  106. Dal-Bianco JP, Beaudoin J, Handschumacher MD, Levine RA. Basic mechanisms of mitral regurgitation. Can J Cardiol. 2014 Sep; 30(9):971-81. PMID: 25151282.
    Citations: 23     Fields:    Translation:Humans
  107. Volo SC, Kim J, Gurevich S, Petashnick M, Kampaktsis P, Feher A, Szulc M, Wong FJ, Devereux RB, Okin PM, Girardi LN, Min JK, Levine RA, Weinsaft JW. Effect of myocardial perfusion pattern on frequency and severity of mitral regurgitation in patients with known or suspected coronary artery disease. Am J Cardiol. 2014 Aug 01; 114(3):355-61. PMID: 24948494; PMCID: PMC4157940.
    Citations: 12     Fields:    Translation:Humans
  108. Nunes MC, Handschumacher MD, Levine RA, Barbosa MM, Carvalho VT, Esteves WA, Zeng X, Guerrero JL, Zheng H, Tan TC, Hung J. Role of LA shape in predicting embolic cerebrovascular events in mitral stenosis: mechanistic insights from 3D echocardiography. JACC Cardiovasc Imaging. 2014 May; 7(5):453-61. PMID: 24831206.
    Citations: 7     Fields:    Translation:Humans
  109. Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-ß-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18; 446(4):870-5. PMID: 24632204.
    Citations: 31     Fields:    Translation:AnimalsCells
  110. Yukawa S, Takeuchi M, Nakazono A, Sakamoto K, Araya K, Eto M, Nishimura Y, Harada M, Levine RA, Otsuji Y. Mitral stenosis reversed by medical treatment for heart failure. Ann Thorac Surg. 2013 Nov; 96(5):e115-7. PMID: 24182508; PMCID: PMC4281521.
    Citations: 1     Fields:    Translation:Humans
  111. Delling FN, Gona P, Larson MG, Lehman B, Manning WJ, Levine RA, Benjamin EJ, Vasan RS. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum. J Am Soc Echocardiogr. 2014 Jan; 27(1):17-23. PMID: 24206636.
    Citations: 12     Fields:    Translation:Humans
  112. Nunes MC, Hung J, Barbosa MM, Esteves WA, Carvalho VT, Lodi-Junqueira L, Fonseca Neto CP, Tan TC, Levine RA. Impact of net atrioventricular compliance on clinical outcome in mitral stenosis. Circ Cardiovasc Imaging. 2013 Nov; 6(6):1001-8. PMID: 24097419.
    Citations: 8     Fields:    Translation:Humans
  113. Beaudoin J, Levine RA, Guerrero JL, Yosefy C, Sullivan S, Abedat S, Handschumacher MD, Szymanski C, Gilon D, Palmeri NO, Vlahakes GJ, Hajjar RJ, Beeri R. Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair. Circulation. 2013 Sep 10; 128(11 Suppl 1):S248-52. PMID: 24030415; PMCID: PMC4281522.
    Citations: 16     Fields:    Translation:Animals
  114. Arokiaraj M, Guerrero L, Levine R, Palacios I. A theoretical cardiac resynchronization therapy method to augment ventricular contraction using polymer-based actuators and mitral regurgitation reduction with devices over left ventricular endocardial pacing wire--an in-vitro study. J Invasive Cardiol. 2013 Aug; 25(8):415-20. PMID: 23913609.
    Citations:    Fields:    Translation:Animals
  115. Beaudoin J, Thai WE, Wai B, Handschumacher MD, Levine RA, Truong QA. Assessment of mitral valve adaptation with gated cardiac computed tomography: validation with three-dimensional echocardiography and mechanistic insight to functional mitral regurgitation. Circ Cardiovasc Imaging. 2013 Sep; 6(5):784-9. PMID: 23873402.
    Citations: 19     Fields:    Translation:Humans
  116. Dal-Bianco JP, Levine RA. Anatomy of the mitral valve apparatus: role of 2D and 3D echocardiography. Cardiol Clin. 2013 May; 31(2):151-64. PMID: 23743068.
    Citations: 25     Fields: