Harvard Catalyst Profiles

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Robert A. Levine, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    NIH
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Principal Investigator
  2. R01HL128099 (LEVINE, ROBERT A) Dec 15, 2015 - Nov 30, 2020
    NIH
    Treating Ventricle and Valve: New Synergies for Ischemic LV Remodeling with MR
    Role: Co-Principal Investigator
  3. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2017
    NIH
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Co-Principal Investigator
  4. R21HL072353 (LEVINE, ROBERT A) Sep 30, 2002 - Jul 31, 2006
    NIH
    ACTIVE PATCH THERAPY FOR ISCHEMIC MITRAL REGURGITATION
    Role: Principal Investigator
  5. R01HL072265 (LEVINE, ROBERT A) Mar 15, 2002 - Nov 30, 2014
    NIH
    Effect of Mitral Regurgitation on Ischemic LV Remodeling
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rong LQ, Lopes AJ, Mitlak HW, Palumbo MC, Mick S, Kim J, Levine RA, Wong SC, Reisman M, Devereux RB, Gaudino M, Weinsaft JW. Relative Impact of Surgical Mitral Repair and MitraClip on Annular Remodeling-A Potential Mechanism for Therapeutic Response to Mitral Repair for Degenerative Mitral Regurgitation. J Cardiothorac Vasc Anesth. 2021 Sep 10. PMID: 34600832.
    Citations:    Fields:    
  2. Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E. Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients. Front Cardiovasc Med. 2021; 8:688396. PMID: 34458332.
    Citations:    
  3. Deferm S, Bertrand PB, Verhaert D, Verbrugge FH, Dauw J, Thoelen K, Giesen A, Bruckers L, Rega F, Thomas JD, Levine RA, Vandervoort PM. Mitral Annular Dynamics in AF Versus Sinus Rhythm: Novel Insights Into the Mechanism of AFMR. JACC Cardiovasc Imaging. 2021 Jul 07. PMID: 34274270.
    Citations:    Fields:    
  4. Levine RA, Nagata Y. Imaging Cardiac Valve Mechanics: A New Frontier. JACC Cardiovasc Imaging. 2021 04; 14(4):794-796. PMID: 33832662.
    Citations:    Fields:    Translation:Humans
  5. Kochav JD, Kim J, Judd R, Kim HW, Klem I, Heitner J, Shah D, Shenoy C, Farzaneh-Far A, Polsani V, Kalil R, Villar-Calle P, Nambiar L, Sultana R, Parker M, Cargile P, Khalique OK, Leon MB, Karmpaliotis D, Ratcliffe M, Levine R, Zoghbi WA, Devereux RB, Moskowitz CS, Kim R, Weinsaft JW. Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2021 04; 14(4):826-839. PMID: 33744130.
    Citations:    Fields:    Translation:Humans
  6. Bertrand PB, Overbey JR, Zeng X, Levine RA, Ailawadi G, Acker MA, Smith PK, Thourani VH, Bagiella E, Miller MA, Gupta L, Mack MJ, Gillinov AM, Giustino G, Moskowitz AJ, Gelijns AC, Bowdish ME, O'Gara PT, Gammie JS, Hung J. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation. J Am Coll Cardiol. 2021 02 16; 77(6):713-724. PMID: 33573741.
    Citations:    Fields:    Translation:Humans
  7. Dal-Bianco JP, Levine RA, Hung J. Mitral Regurgitation Postinfarction: The Mitral Valve Adapts to the Times. Circ Cardiovasc Imaging. 2020 12; 13(12):e012130. PMID: 33317331.
    Citations:    Fields:    Translation:Humans
  8. Bertrand PB, Churchill TW, Yucel E, Namasivayam M, Bernard S, Nagata Y, He W, Andrews CT, Picard MH, Weyman AE, Levine RA, Hung J. Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction. Eur Heart J. 2020 12 01; 41(45):4321-4328. PMID: 33221855.
    Citations: 1     Fields:    Translation:Humans
  9. Onoue T, Iwataki M, Araki M, Akashi J, Kitano T, Nabeshima Y, Hei S, Nagata Y, Hayashi A, Tsuda Y, Sonoda S, Fujino Y, Levine RA, Otsuji Y. Novel noninvasive estimation of mixed venous oxygen saturation by echocardiography and expired gas analysis. Am J Physiol Heart Circ Physiol. 2020 11 01; 319(5):H1078-H1086. PMID: 32946269.
    Citations:    Fields:    Translation:Humans
  10. Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J. Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes. JACC Cardiovasc Imaging. 2020 12; 13(12):2513-2526. PMID: 32950446.
    Citations:    Fields:    Translation:Humans
  11. Bertrand PB, Nagata Y, Namasivayam M, Levine RA. The Artifact that Tells the Truth: Color Doppler Splay Unmasking Significant Mitral Regurgitation. J Am Soc Echocardiogr. 2020 10; 33(10):1220-1222. PMID: 32855003.
    Citations:    Fields:    Translation:Humans
  12. Kim J, Yum B, Palumbo MC, Sultana R, Wright N, Das M, You C, Moskowitz CS, Levine RA, Devereux RB, Weinsaft JW. Left Atrial Strain Impairment Precedes Geometric Remodeling as a Marker of Post-Myocardial Infarction Diastolic Dysfunction. JACC Cardiovasc Imaging. 2020 10; 13(10):2099-2113. PMID: 32828776.
    Citations: 4     Fields:    Translation:Humans
  13. Nagata Y, Iwataki M, Nabeshima Y, Hei S, Onoue T, Hayashi A, Otani K, Tsuda Y, Araki M, Kim DH, Song JK, Hayashida A, Toki M, Yuasa T, Mizukami N, Nishimura Y, Levine RA, Otsuji Y. Potential mechanism of left ventricular spherical remodeling: association of mitral valve complex-myocardium longitudinal tissue remodeling mismatch. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H694-H704. PMID: 32795182.
    Citations:    Fields:    Translation:Humans
  14. Bartko PE, Hülsmann M, Hung J, Pavo N, Levine RA, Pibarot P, Vahanian A, Stone GW, Goliasch G. Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction. Eur Heart J. 2020 08 01; 41(29):2799-2810. PMID: 32350503.
    Citations: 7     Fields:    Translation:Humans
  15. Namasivayam M, He W, Churchill TW, Capoulade R, Liu S, Lee H, Danik JS, Picard MH, Pibarot P, Levine RA, Hung J. Transvalvular Flow Rate Determines Prognostic Value of Aortic Valve Area in Aortic Stenosis. J Am Coll Cardiol. 2020 04 21; 75(15):1758-1769. PMID: 32299587.
    Citations: 4     Fields:    Translation:Humans
  16. Liu S, Churchill J, Hua L, Zeng X, Rhoades V, Namasivayam M, Baliyan V, Ghoshhajra BB, Dong T, Dal-Bianco JP, Passeri JJ, Levine RA, Hung J. Direct Planimetry of Left Ventricular Outflow Tract Area by Simultaneous Biplane Imaging: Challenging the Need for a Circular Assumption of the Left Ventricular Outflow Tract in the Assessment of Aortic Stenosis. J Am Soc Echocardiogr. 2020 04; 33(4):461-468. PMID: 32248906.
    Citations:    Fields:    Translation:Humans
  17. Yang LT, Ahn SW, Li Z, Benfari G, Mankad R, Takeuchi M, Levine RA, Enriquez-Sarano M, Michelena HI. Mitral Valve Prolapse Patients with Less than Moderate Mitral Regurgitation Exhibit Early Cardiac Chamber Remodeling. J Am Soc Echocardiogr. 2020 07; 33(7):815-825.e2. PMID: 32222479.
    Citations: 1     Fields:    Translation:Humans
  18. Cristina de Castro Faria S, Costa HS, Hung J, Gorle de Miranda Chaves A, Paes de Oliveira FA, Padilha da Silva JL, Esteves WAM, Tan TC, Levine RA, Pereira Nunes MC. Pulmonary Artery Systolic Pressure Response to Exercise in Patients with Rheumatic Mitral Stenosis: Determinants and Prognostic Value. J Am Soc Echocardiogr. 2020 05; 33(5):550-558. PMID: 32127221.
    Citations:    Fields:    Translation:Humans
  19. Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2020 02 04; 75(4):395-405. PMID: 32000951.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Hei S, Iwataki M, Jang JY, Kuwaki H, Fukuda S, Kim YJ, Toki M, Onoue T, Hayashi A, Nishino S, Watanabe N, Hayashida A, Tsuda Y, Araki M, Nishimura Y, Song JK, Yoshida K, Levine RA, Otsuji Y. Relations of Augmented Systolic Annular Expansion and Leaflet/Papillary Muscle Dynamics in Late-Systolic Mitral Valve Prolapse Evaluated by Echocardiography with a Speckle Tracking Analysis. Int Heart J. 2020; 61(5):970-978. PMID: 32999196.
    Citations:    Fields:    Translation:Humans
  21. Kim J, Palumbo MC, Khalique OK, Rong LQ, Sultana R, Das M, Jantz J, Nagata Y, Devereux RB, Wong SC, Bergman GW, Levine RA, Ratcliffe MB, Weinsaft JW. Transcatheter MitraClip repair alters mitral annular geometry - device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response. Cardiovasc Ultrasound. 2019 Dec 26; 17(1):31. PMID: 31878931.
    Citations: 1     Fields:    Translation:Humans
  22. Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study. PLoS One. 2019; 14(10):e0223472. PMID: 31600276.
    Citations: 4     Fields:    Translation:Animals
  23. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 05 22; 11(493). PMID: 31118289.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  24. Yu M, Georges A, Tucker NR, Kyryachenko S, Toomer K, Schott JJ, Delling FN, Fernandez-Friera L, Solis J, Ellinor PT, Levine RA, Slaugenhaupt SA, Hagège AA, Dina C, Jeunemaitre X, Milan DJ, Norris RA, Bouatia-Naji N. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 05; 12(5):e002497. PMID: 31112420.
    Citations: 5     Fields:    Translation:HumansAnimals
  25. Kampaktsis PN, Albert BJ, Kim J, Xie LX, Brouwer LR, Tehrani NH, Villanueva M, Choi DY, Szulc M, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW. Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance-Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing. J Am Heart Assoc. 2019 03 05; 8(5):e010974. PMID: 30808228.
    Citations: 1     Fields:    Translation:Humans
  26. Schwammenthal E, Hagège AA, Levine RA. Does the Flow Know? Mitral Regurgitant Jet Direction and Need for Valve Repair in Hypertrophic Obstructive Cardiomyopathy. J Am Soc Echocardiogr. 2019 03; 32(3):341-343. PMID: 30827370.
    Citations:    Fields:    Translation:Humans
  27. Chetrit M, Roujol S, Picard MH, Timmins L, Manning WJ, Rudski LG, Levine RA, Afilalo J. Optimal Technique for Measurement of Linear Left Ventricular Dimensions. J Am Soc Echocardiogr. 2019 04; 32(4):476-483.e1. PMID: 30826223.
    Citations: 2     Fields:    Translation:Humans
  28. Kim J, Alakbarli J, Palumbo MC, Xie LX, Rong LQ, Tehrani NH, Brouwer LR, Devereux RB, Wong SC, Bergman GW, Khalique OK, Levine RA, Ratcliffe MB, Weinsaft JW. Left ventricular geometry predicts optimal response to percutaneous mitral repair via MitraClip: Integrated assessment by two- and three-dimensional echocardiography. Catheter Cardiovasc Interv. 2019 05 01; 93(6):1152-1160. PMID: 30790417.
    Citations: 2     Fields:    Translation:Humans
  29. Borger MA, Mansour MC, Levine RA. Atrial Fibrillation and Mitral Valve Prolapse: Time to Intervene? J Am Coll Cardiol. 2019 01 29; 73(3):275-277. PMID: 30678756.
    Citations: 4     Fields:    Translation:Humans
  30. Onoue T, Iwataki M, Araki M, Itoh H, Isotani A, Umeda H, Fukuda S, Nagata Y, Tsuda Y, Fujino Y, Hanyu M, Ando K, Shirai S, Takeuchi M, Saeki S, Levine RA, Otsuji Y. Insights into the mechanism of paradoxical low-flow, low-pressure gradient severe aortic stenosis: association with reduced O2 consumption by the whole body. . 2019 04 01; 316(4):H840-H848. PMID: 30681367.
    Citations: 2     Translation:Humans
  31. Levine RA, Nagata Y, Dal-Bianco JP. Left Ventricular Dyssynchrony and the Mitral Valve Apparatus: An Orchestra That Needs to Play in Sync. JACC Cardiovasc Imaging. 2019 09; 12(9):1738-1740. PMID: 30660517.
    Citations: 1     Fields:    Translation:Humans
  32. Hei S, Iwataki M, Jang JY, Kuwaki H, Mahara K, Fukuda S, Kim YJ, Nabeshima Y, Onoue T, Nagata Y, Nishino S, Watanabe N, Takeuchi M, Nishimura Y, Song JK, Levine RA, Otsuji Y. Possible mechanism of late systolic mitral valve prolapse: systolic superior shift of leaflets secondary to annular dilatation that causes papillary muscle traction. . 2019 03 01; 316(3):H629-H638. PMID: 30575434.
    Citations: 4     Translation:Humans
  33. Kim J, Alakbarli J, Yum B, Tehrani NH, Pollie MP, Abouzeid C, Di Franco A, Ratcliffe MB, Poppas A, Levine RA, Devereux RB, Weinsaft JW. Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography. Int J Cardiovasc Imaging. 2019 Apr; 35(4):683-693. PMID: 30460581.
    Citations: 5     Fields:    Translation:Humans
  34. Toomer K, Sauls K, Fulmer D, Guo L, Moore K, Glover J, Stairley R, Bischoff J, Levine RA, Norris RA. Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development. Anat Rec (Hoboken). 2019 01; 302(1):117-124. PMID: 30288957.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Groarke JD, Galazka PZ, Cirino AL, Lakdawala NK, Thune JJ, Bundgaard H, Orav EJ, Levine RA, Ho CY. Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers. Eur Heart J Cardiovasc Imaging. 2018 10 01; 19(10):1109-1116. PMID: 30052928.
    Citations: 4     Fields:    Translation:HumansCells
  36. Athayde GRS, Nascimento BR, Elmariah S, Lodi-Junqueira L, Soares JR, Saad GP, da Silva JLP, Tan TC, Hung J, Palacios IF, Levine RA, Nunes MCP. Impact of left atrial compliance improvement on functional status after percutaneous mitral valvuloplasty. Catheter Cardiovasc Interv. 2019 01 01; 93(1):156-163. PMID: 30244517.
    Citations: 1     Fields:    Translation:Humans
  37. Yoshitani H, Isotani A, Song JK, Shirai S, Umeda H, Jang JY, Onoue T, Toki M, Sun BJ, Kim DH, Kagiyama N, Hayashida A, Song JM, Eto M, Nishimura Y, Ando K, Hanyu M, Yoshida K, Levine RA, Otsuji Y. Surgical as Opposed to Transcatheter Aortic Valve Replacement Improves Basal Interventricular Septal Hypertrophy. Circ J. 2018 10 25; 82(11):2887-2895. PMID: 30135322.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  38. Levine RA, Jerosch-Herold M, Hajjar RJ. Mitral Valve Prolapse: A Disease of Valve and Ventricle. J Am Coll Cardiol. 2018 08 21; 72(8):835-837. PMID: 30115221.
    Citations: 5     Fields:    Translation:Humans
  39. Bartko PE, Pavo N, Pérez-Serradilla A, Arfsten H, Neuhold S, Wurm R, Lang IM, Strunk G, Dal-Bianco JP, Levine RA, Hülsmann M, Goliasch G. Evolution of secondary mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2018 06 01; 19(6):622-629. PMID: 29534164.
    Citations: 7     Fields:    Translation:Humans
  40. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277. PMID: 29020406.
    Citations: 10     Fields:    Translation:HumansCells
  41. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642. PMID: 29626080.
    Citations: 1     Fields:    Translation:Humans
  42. Le Tourneau T, Mérot J, Rimbert A, Le Scouarnec S, Probst V, Le Marec H, Levine RA, Schott JJ. Genetics of syndromic and non-syndromic mitral valve prolapse. Heart. 2018 06; 104(12):978-984. PMID: 29352010.
    Citations: 10     Fields:    Translation:HumansAnimals
  43. Kim DH, Morris B, Guerrero JL, Sullivan SM, Hung J, Levine RA. Ovine Model of Ischemic Mitral Regurgitation. Methods Mol Biol. 2018; 1816:295-308. PMID: 29987829.
    Citations:    Fields:    Translation:Animals
  44. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677. PMID: 29248661.
    Citations: 12     Fields:    Translation:Humans
  45. Kataoka A, Zeng X, Guerrero JL, Kozak A, Braithwaite G, Levine RA, Vlahakes GJ, Hung J. Application of polymer-mesh device to remodel left ventricular-mitral valve apparatus in ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 2018 04; 155(4):1485-1493. PMID: 29249485.
    Citations: 1     Fields:    Translation:Animals
  46. Parwani P, Avierinos JF, Levine RA, Delling FN. Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights. Prog Cardiovasc Dis. 2017 Nov - Dec; 60(3):361-369. PMID: 29122631.
    Citations: 3     Fields:    Translation:Humans
  47. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 15     Fields:    Translation:HumansAnimals
  48. Di Franco A, Kim J, Rodriguez-Diego S, Khalique O, Siden JY, Goldburg SR, Mehta NK, Srinivasan A, Ratcliffe MB, Levine RA, Crea F, Devereux RB, Weinsaft JW. Multiplanar strain quantification for assessment of right ventricular dysfunction and non-ischemic fibrosis among patients with ischemic mitral regurgitation. PLoS One. 2017; 12(9):e0185657. PMID: 28961271.
    Citations: 5     Fields:    Translation:Humans
  49. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  50. Nunes MCP, Tan TC, Elmariah S, Lodi-Junqueira L, Nascimento BR, do Lago R, Padilha da Silva JL, Reis RCP, Zeng X, Palacios IF, Hung J, Levine RA. Net atrioventricular compliance is an independent predictor of cardiovascular death in mitral stenosis. Heart. 2017 12; 103(23):1891-1898. PMID: 28780580.
    Citations: 5     Fields:    Translation:Humans
  51. Yang DH, Kim DH, Handschumacher MD, Levine RA, Kim JB, Sun BJ, Jang JY, Kim N, Baek S, Kang JW, Song JM, Kang DH, Lim TH, Song JK. In vivo assessment of aortic root geometry in normal controls using 3D analysis of computed tomography. Eur Heart J Cardiovasc Imaging. 2017 Jul 01; 18(7):780-786. PMID: 27461206.
    Citations: 2     Fields:    Translation:Humans
  52. Marsit O, Royer O, Drolet MC, Arsenault M, Couet J, Morin S, Levine RA, Pibarot P, Beaudoin J. Early Activation of Growth Pathways in Mitral Leaflets Exposed to Aortic Regurgitation: New Insights from an Animal Model. J Heart Valve Dis. 2017 05; 26(3):281-289. PMID: 29092112.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Bertrand PB, Schwammenthal E, Levine RA, Vandervoort PM. Exercise Dynamics in Secondary Mitral Regurgitation: Pathophysiology and Therapeutic Implications. Circulation. 2017 Jan 17; 135(3):297-314. PMID: 28093494.
    Citations: 10     Fields:    Translation:Humans
  54. Hayashi A, Fukuda S, Mahara K, Hei S, Onoue T, Kado Y, Nagata Y, Iwataki M, Otani K, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Left Atrial Remodeling in Segmental vs. Global Mitral Valve Prolapse - Three-Dimensional Echocardiography. Circ J. 2016 Nov 25; 80(12):2533-2540. PMID: 27829586.
    Citations:    Fields:    Translation:Humans
  55. Kim J, Di Franco A, Seoane T, Srinivasan A, Kampaktsis PN, Geevarghese A, Goldburg SR, Khan SA, Szulc M, Ratcliffe MB, Levine RA, Morgan AE, Maddula P, Rozenstrauch M, Shah T, Devereux RB, Weinsaft JW. Right Ventricular Dysfunction Impairs Effort Tolerance Independent of Left Ventricular Function Among Patients Undergoing Exercise Stress Myocardial Perfusion Imaging. Circ Cardiovasc Imaging. 2016 Nov; 9(11). PMID: 27903538.
    Citations: 12     Fields:    Translation:Humans
  56. Capoulade R, Zeng X, Overbey JR, Ailawadi G, Alexander JH, Ascheim D, Bowdish M, Gelijns AC, Grayburn P, Kron IL, Levine RA, Mack MJ, Melnitchouk S, Michler RE, Mullen JC, O'Gara P, Parides MK, Smith P, Voisine P, Hung J. Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty. Circulation. 2016 Oct 25; 134(17):1247-1256. PMID: 27777294.
    Citations: 16     Fields:    Translation:Humans
  57. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208.
    Citations: 30     Fields:    Translation:AnimalsCells
  58. Pantoja JL, Morgan AE, Grossi EA, Jensen MO, Weinsaft JW, Levine RA, Ge L, Ratcliffe MB. Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall. Ann Thorac Surg. 2017 Mar; 103(3):820-827. PMID: 27720201.
    Citations: 2     Fields:    Translation:Animals
  59. Fukuda S, Song JK, Mahara K, Kuwaki H, Jang JY, Takeuchi M, Sun BJ, Kim YJ, Miyamoto T, Oginosawa Y, Sonoda S, Eto M, Nishimura Y, Takanashi S, Levine RA, Otsuji Y. Basal Left Ventricular Dilatation and Reduced Contraction in Patients With Mitral Valve Prolapse Can Be Secondary to Annular Dilatation: Preoperative and Postoperative Speckle-Tracking Echocardiographic Study on Left Ventricle and Mitral Valve Annulus Interaction. Circ Cardiovasc Imaging. 2016 Oct; 9(10). PMID: 27729364.
    Citations: 7     Fields:    Translation:Humans
  60. Hung J, Levine RA. Pixels or Pixie Dust? Grading of mitral regurgitation using intensity analysis of continuous wave Doppler. Heart. 2017 02; 103(3):177-178. PMID: 27609944.
    Citations:    Fields:    Translation:Humans
  61. Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767. PMID: 28417861.
    Citations: 4     Fields:    Translation:HumansCells
  62. Dal-Bianco JP, Bartko PE, Levine RA. The power of ultrasound: treating secondary MR with sound waves. Eur Heart J Cardiovasc Imaging. 2016 10; 17(10):1108-9. PMID: 27550662.
    Citations:    Fields:    Translation:Humans
  63. Dal-Bianco JP, Bartko PE, Levine RA. Anticipating the Vicious Circle of Postinfarction Mitral Regurgitation: Imaging Insights. Circ Cardiovasc Imaging. 2016 07; 9(7). PMID: 27406845.
    Citations:    Fields:    Translation:Humans
  64. Beaudoin J, Singh JP, Szymonifka J, Zhou Q, Levine RA, Januzzi JL, Truong QA. Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy-The BIOCRT Study. Can J Cardiol. 2016 12; 32(12):1478-1484. PMID: 27527259.
    Citations: 3     Fields:    Translation:Humans
  65. Delling FN, Rong J, Larson MG, Lehman B, Fuller D, Osypiuk E, Stantchev P, Hackman B, Manning WJ, Benjamin EJ, Levine RA, Vasan RS. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study. Circulation. 2016 Apr 26; 133(17):1688-95. PMID: 27006478.
    Citations: 17     Fields:    Translation:Humans
  66. Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1. PMID: 26976355.
    Citations:    Fields:    Translation:Humans
  67. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87. PMID: 26796392.
    Citations: 31     Fields:    Translation:Animals
  68. Goyal P, Kim J, Feher A, Ma CL, Gurevich S, Veal DR, Szulc M, Wong FJ, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW. Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention. Coron Artery Dis. 2015 Dec; 26(8):642-50. PMID: 26049923.
    Citations: 3     Fields:    Translation:Humans
  69. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
    Citations: 74     Fields:    Translation:Humans
  70. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community". Circulation. 2015 Oct 06; 132(14):e187-8. PMID: 26438779.
    Citations:    Fields:    Translation:Humans
  71. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Jeunemaitre X. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct; 47(10):1206-11. PMID: 26301497.
    Citations: 40     Fields:    Translation:HumansAnimals
  72. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  73. Hagège AA, Carpentier A, Levine RA. Dynamic changes of the mitral valve annulus: new look at mitral valve diseases. Circ Cardiovasc Imaging. 2015 May; 8(5). PMID: 25956923.
    Citations: 1     Fields:    Translation:Humans
  74. Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JS, Channick RN, Langleben D, Rudski LG, Hua L, Handschumacher MD, Picard MH, Levine RA. Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension. Circ Cardiovasc Imaging. 2015 May; 8(5). PMID: 25977303.
    Citations: 6     Fields:    Translation:Humans
  75. Blanke P, Dvir D, Cheung A, Levine RA, Thompson C, Webb JG, Leipsic J. Mitral Annular Evaluation With CT in the Context of Transcatheter Mitral Valve Replacement. JACC Cardiovasc Imaging. 2015 May; 8(5):612-615. PMID: 25937198.
    Citations: 23     Fields:    Translation:Humans
  76. Judge DP, Neamatalla H, Norris RA, Levine RA, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA. Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities. J Cardiovasc Dev Dis. 2015; 2(2):48-65. PMID: 26819945.
    Citations: 5     
  77. Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ. Reply to "Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions". . 2015 Feb 15; 308(4):H365-6. PMID: 25684739.
    Citations: 1     Translation:Animals
  78. Bertrand PB, Verbrugge FH, Verhaert D, Smeets CJ, Grieten L, Mullens W, Gutermann H, Dion RA, Levine RA, Vandervoort PM. Mitral valve area during exercise after restrictive mitral valve annuloplasty: importance of diastolic anterior leaflet tethering. J Am Coll Cardiol. 2015 Feb 10; 65(5):452-61. PMID: 25660923.
    Citations: 9     Fields:    Translation:Humans
  79. Shapero K, Wylie-Sears J, Levine RA, Mayer JE, Bischoff J. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015 Mar; 80:175-85. PMID: 25633835.
    Citations: 27     Fields:    Translation:AnimalsCells
  80. Dal-Bianco JP, Levine RA. The mitral valve is an actively adapting tissue: new imaging evidence. Eur Heart J Cardiovasc Imaging. 2015 Mar; 16(3):286-7. PMID: 25617031.
    Citations: 4     Fields:    Translation:HumansAnimals
  81. Zeng X, Zou L, Levine RA, Guerrero JL, Handschumacher MD, Sullivan SM, Braithwaite GJC, Stone JR, Solis J, Muratoglu OK, Vlahakes GJ, Hung J. Efficacy of polymer injection for ischemic mitral regurgitation: persistent reduction of mitral regurgitation and attenuation of left ventricular remodeling. JACC Cardiovasc Interv. 2015 Feb; 8(2):355-363. PMID: 25596792.
    Citations: 2     Fields:    Translation:Animals
  82. Iwataki M, Kim YJ, Sun BJ, Jang JY, Takeuchi M, Fukuda S, Otani K, Yoshitani H, Ohe H, Kohno R, Oginosawa Y, Abe H, Levine RA, Song JK, Otsuji Y. Different characteristics of heart failure due to pump failure and bradyarrhythmia. J Echocardiogr. 2015 Mar; 13(1):27-34. PMID: 25750577.
    Citations: 4     Fields:    Translation:Humans
  83. Levine RA, Schwammenthal E, Song JK. Diastolic leading to systolic anterior motion: new technology reveals physiology. J Am Coll Cardiol. 2014 Nov 11; 64(19):1996-9. PMID: 25440094.
    Citations: 5     Fields:    Translation:Humans
  84. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Familial clustering of mitral valve prolapse in the community. Circulation. 2015 Jan 20; 131(3):263-8. PMID: 25361552.
    Citations: 19     Fields:    Translation:Humans
  85. Blanke P, Dvir D, Cheung A, Ye J, Levine RA, Precious B, Berger A, Stub D, Hague C, Murphy D, Thompson C, Munt B, Moss R, Boone R, Wood D, Pache G, Webb J, Leipsic J. A simplified D-shaped model of the mitral annulus to facilitate CT-based sizing before transcatheter mitral valve implantation. J Cardiovasc Comput Tomogr. 2014 Nov-Dec; 8(6):459-67. PMID: 25467833.
    Citations: 21     Fields:    Translation:Humans
  86. Iwataki M, Takeuchi M, Otani K, Kuwaki H, Yoshitani H, Abe H, Lang RM, Levine RA, Otsuji Y. Calcific extension towards the mitral valve causes non-rheumatic mitral stenosis in degenerative aortic stenosis: real-time 3D transoesophageal echocardiography study. Open Heart. 2014; 1(1):e000136. PMID: 25332828.
    Citations: 4     
  87. Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ. Characterizing preclinical models of ischemic heart failure: differences between LAD and LCx infarctions. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1478-86. PMID: 25217654.
    Citations: 18     Fields:    Translation:Animals
  88. Kim DH, Handschumacher MD, Levine RA, Sun BJ, Jang JY, Yang DH, Kang JW, Song JM, Kang DH, Lim TH, Song JK. Aortic valve adaptation to aortic root dilatation: insights into the mechanism of functional aortic regurgitation from 3-dimensional cardiac computed tomography. Circ Cardiovasc Imaging. 2014 Sep; 7(5):828-35. PMID: 25051951.
    Citations: 12     Fields:    Translation:Humans
  89. Dal-Bianco JP, Beaudoin J, Handschumacher MD, Levine RA. Basic mechanisms of mitral regurgitation. Can J Cardiol. 2014 Sep; 30(9):971-81. PMID: 25151282.
    Citations: 19     Fields:    Translation:Humans
  90. Volo SC, Kim J, Gurevich S, Petashnick M, Kampaktsis P, Feher A, Szulc M, Wong FJ, Devereux RB, Okin PM, Girardi LN, Min JK, Levine RA, Weinsaft JW. Effect of myocardial perfusion pattern on frequency and severity of mitral regurgitation in patients with known or suspected coronary artery disease. Am J Cardiol. 2014 Aug 01; 114(3):355-61. PMID: 24948494.
    Citations: 9     Fields:    Translation:Humans
  91. Nunes MC, Handschumacher MD, Levine RA, Barbosa MM, Carvalho VT, Esteves WA, Zeng X, Guerrero JL, Zheng H, Tan TC, Hung J. Role of LA shape in predicting embolic cerebrovascular events in mitral stenosis: mechanistic insights from 3D echocardiography. JACC Cardiovasc Imaging. 2014 May; 7(5):453-61. PMID: 24831206.
    Citations: 5     Fields:    Translation:Humans
  92. Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-ß-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18; 446(4):870-5. PMID: 24632204.
    Citations: 21     Fields:    Translation:AnimalsCells
  93. Yukawa S, Takeuchi M, Nakazono A, Sakamoto K, Araya K, Eto M, Nishimura Y, Harada M, Levine RA, Otsuji Y. Mitral stenosis reversed by medical treatment for heart failure. Ann Thorac Surg. 2013 Nov; 96(5):e115-7. PMID: 24182508.
    Citations: 1     Fields:    Translation:Humans
  94. Delling FN, Gona P, Larson MG, Lehman B, Manning WJ, Levine RA, Benjamin EJ, Vasan RS. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum. J Am Soc Echocardiogr. 2014 Jan; 27(1):17-23. PMID: 24206636.
    Citations: 11     Fields:    Translation:Humans
  95. Nunes MC, Hung J, Barbosa MM, Esteves WA, Carvalho VT, Lodi-Junqueira L, Fonseca Neto CP, Tan TC, Levine RA. Impact of net atrioventricular compliance on clinical outcome in mitral stenosis. Circ Cardiovasc Imaging. 2013 Nov; 6(6):1001-8. PMID: 24097419.
    Citations: 7     Fields:    Translation:Humans
  96. Beaudoin J, Levine RA, Guerrero JL, Yosefy C, Sullivan S, Abedat S, Handschumacher MD, Szymanski C, Gilon D, Palmeri NO, Vlahakes GJ, Hajjar RJ, Beeri R. Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair. Circulation. 2013 Sep 10; 128(11 Suppl 1):S248-52. PMID: 24030415.
    Citations: 14     Fields:    Translation:Animals
  97. Arokiaraj M, Guerrero L, Levine R, Palacios I. A theoretical cardiac resynchronization therapy method to augment ventricular contraction using polymer-based actuators and mitral regurgitation reduction with devices over left ventricular endocardial pacing wire--an in-vitro study. J Invasive Cardiol. 2013 Aug; 25(8):415-20. PMID: 23913609.
    Citations:    Fields:    Translation:Animals
  98. Beaudoin J, Thai WE, Wai B, Handschumacher MD, Levine RA, Truong QA. Assessment of mitral valve adaptation with gated cardiac computed tomography: validation with three-dimensional echocardiography and mechanistic insight to functional mitral regurgitation. Circ Cardiovasc Imaging. 2013 Sep; 6(5):784-9. PMID: 23873402.
    Citations: 18     Fields:    Translation:Humans
  99. Dal-Bianco JP, Levine RA. Anatomy of the mitral valve apparatus: role of 2D and 3D echocardiography. Cardiol Clin. 2013 May; 31(2):151-64. PMID: 23743068.
    Citations: 17     Fields:    Translation:Humans
  100. Rawlins SR, Mullen CM, Simon HM, Kim T, Landas SK, Walser MS, Levine RA. Wedge and needle liver biopsies show discordant histopathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery. Gastroenterol Rep (Oxf). 2013 Jul; 1(1):51-7. PMID: 24759667.
    Citations: 6     
  101. Beaudoin J, Handschumacher MD, Zeng X, Hung J, Morris EL, Levine RA, Schwammenthal E. Mitral valve enlargement in chronic aortic regurgitation as a compensatory mechanism to prevent functional mitral regurgitation in the dilated left ventricle. J Am Coll Cardiol. 2013 Apr 30; 61(17):1809-16. PMID: 23500248.
    Citations: 24     Fields:    Translation:Humans
  102. Jensen MO, Hagège AA, Otsuji Y, Levine RA. The unsaddled annulus: biomechanical culprit in mitral valve prolapse? Circulation. 2013 Feb 19; 127(7):766-8. PMID: 23429895.
    Citations: 13     Fields:    Translation:Humans
  103. Chinitz JS, Chen D, Goyal P, Wilson S, Islam F, Nguyen T, Wang Y, Hurtado-Rua S, Simprini L, Cham M, Levine RA, Devereux RB, Weinsaft JW. Mitral apparatus assessment by delayed enhancement CMR: relative impact of infarct distribution on mitral regurgitation. JACC Cardiovasc Imaging. 2013 Feb; 6(2):220-34. PMID: 23489536.
    Citations: 25     Fields:    Translation:Humans
  104. Rahmani A, Rasmussen AQ, Honge JL, Ostli B, Levine RA, Hagège A, Nygaard H, Nielsen SL, Jensen MO. Mitral valve mechanics following posterior leaflet patch augmentation. J Heart Valve Dis. 2013 Jan; 22(1):28-35. PMID: 23610985.
    Citations: 3     Fields:    Translation:Animals
  105. Szymanski C, Bel A, Cohen I, Touchot B, Handschumacher MD, Desnos M, Carpentier A, Menasché P, Hagège AA, Levine RA, Messas E. Comprehensive annular and subvalvular repair of chronic ischemic mitral regurgitation improves long-term results with the least ventricular remodeling. Circulation. 2012 Dec 04; 126(23):2720-7. PMID: 23139296.
    Citations: 10     Fields:    Translation:Animals
  106. Otani K, Takeuchi M, Kaku K, Haruki N, Yoshitani H, Eto M, Tamura M, Okazaki M, Abe H, Fujino Y, Nishimura Y, Levine RA, Otsuji Y. Evidence of a vicious cycle in mitral regurgitation with prolapse: secondary tethering attributed to primary prolapse demonstrated by three-dimensional echocardiography exacerbates regurgitation. Circulation. 2012 Sep 11; 126(11 Suppl 1):S214-21. PMID: 22965986.
    Citations: 11     Fields:    Translation:Humans
  107. Gu JW, Herrmann BS, Levine RA, Melcher JR. Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus. J Assoc Res Otolaryngol. 2012 Dec; 13(6):819-33. PMID: 22869301.
    Citations: 70     Fields:    Translation:Humans
  108. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19. PMID: 22843703.
    Citations: 30     Fields:    Translation:AnimalsCells
  109. Ofman P, Cook JR, Navaravong L, Levine RA, Peralta A, Gaziano JM, Djousse L, Curillova Z, Hoffmeister P, Smoot K, Jiang L, Tighe DA, Stoenescu ML. T-wave inversion and diastolic dysfunction in patients with electrocardiographic left ventricular hypertrophy. J Electrocardiol. 2012 Nov-Dec; 45(6):764-9. PMID: 22819483.
    Citations: 1     Fields:    Translation:Humans
  110. Beaudoin J, Levine RA, Yosefy C, Beeri R, Neary JH, Morgan NV, Passeri JJ. Severe ischemic mitral regurgitation despite normally contracting subpapillary myocardium. Circulation. 2012 Jul 03; 126(1):138-41. PMID: 22753536.
    Citations: 1     Fields:    Translation:Humans
  111. Nakai H, Kaku K, Takeuchi M, Otani K, Yoshitani H, Haruki N, Tamura M, Okazaki M, Abe H, Tsutsumi A, Levine RA, Otsuji Y. Different influences of left ventricular remodeling on anterior and posterior mitral leaflet tethering. Circ J. 2012; 76(10):2481-7. PMID: 22785152.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  112. de Vlaming A, Sauls K, Hajdu Z, Visconti RP, Mehesz AN, Levine RA, Slaugenhaupt SA, Hagège A, Chester AH, Markwald RR, Norris RA. Atrioventricular valve development: new perspectives on an old theme. Differentiation. 2012 Jul; 84(1):103-16. PMID: 22579502.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  113. Melcher JR, Knudson IM, Levine RA. Subcallosal brain structure: correlation with hearing threshold at supra-clinical frequencies (>8 kHz), but not with tinnitus. Hear Res. 2013 Jan; 295:79-86. PMID: 22504034.
    Citations: 31     Fields:    Translation:Humans
  114. Hung J, Solis J, Handschumacher MD, Guerrero JL, Levine RA. Persistence of mitral regurgitation following ring annuloplasty: is the papillary muscle outside or inside the ring? J Heart Valve Dis. 2012 Mar; 21(2):218-24. PMID: 22645858.
    Citations: 4     Fields:    Translation:Animals
  115. Meris A, Amigoni M, Verma A, Thune JJ, Køber L, Velazquez E, McMurray JJ, Pfeffer MA, Califf R, Levine RA, Solomon SD. Mechanisms and predictors of mitral regurgitation after high-risk myocardial infarction. J Am Soc Echocardiogr. 2012 May; 25(5):535-42. PMID: 22305962.
    Citations: 6     Fields:    Translation:Humans
  116. Kim K, Kaji S, An Y, Yoshitani H, Takeuchi M, Levine RA, Otsuji Y, Furukawa Y. Mechanism of asymmetric leaflet tethering in ischemic mitral regurgitation: 3D analysis with multislice CT. JACC Cardiovasc Imaging. 2012 Feb; 5(2):230-2. PMID: 22340833.
    Citations: 7     Fields:    Translation:Humans
  117. Granier M, Jensen MO, Honge JL, Bel A, Menasché P, Nielsen SL, Carpentier A, Levine RA, Hagège AA. Consequences of mitral valve prolapse on chordal tension: ex vivo and in vivo studies in large animal models. J Thorac Cardiovasc Surg. 2011 Dec; 142(6):1585-7. PMID: 21955468.
    Citations: 7     Fields:    Translation:Animals
  118. Szymanski C, Levine RA, Tribouilloy C, Zheng H, Handschumacher MD, Tawakol A, Hung J. Impact of mitral regurgitation on exercise capacity and clinical outcomes in patients with ischemic left ventricular dysfunction. Am J Cardiol. 2011 Dec 15; 108(12):1714-20. PMID: 21943932.
    Citations: 10     Fields:    Translation:Humans
  119. Hagège AA, Bruneval P, Levine RA, Desnos M, Neamatalla H, Judge DP. The mitral valve in hypertrophic cardiomyopathy: old versus new concepts. J Cardiovasc Transl Res. 2011 Dec; 4(6):757-66. PMID: 21909825.
    Citations: 12     Fields:    Translation:HumansAnimals
  120. Judge DP, Markwald RR, Hagège AA, Levine RA. Translational research on the mitral valve: from developmental mechanisms to new therapies. J Cardiovasc Transl Res. 2011 Dec; 4(6):699-701. PMID: 21901526.
    Citations: 6     Fields:    Translation:HumansAnimals
  121. Zeng X, Levine RA, Hua L, Morris EL, Kang Y, Flaherty M, Morgan NV, Hung J. Diagnostic value of vena contracta area in the quantification of mitral regurgitation severity by color Doppler 3D echocardiography. Circ Cardiovasc Imaging. 2011 Sep; 4(5):506-13. PMID: 21730026.
    Citations: 32     Fields:    Translation:Humans
  122. Yosefy C, Beeri R, Guerrero JL, Vaturi M, Scherrer-Crosbie M, Handschumacher MD, Levine RA. Mitral regurgitation after anteroapical myocardial infarction: new mechanistic insights. Circulation. 2011 Apr 12; 123(14):1529-36. PMID: 21444880.
    Citations: 6     Fields:    Translation:HumansAnimals
  123. Jensen MO, Jensen H, Levine RA, Yoganathan AP, Andersen NT, Nygaard H, Hasenkam JM, Nielsen SL. Saddle-shaped mitral valve annuloplasty rings improve leaflet coaptation geometry. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):697-703. PMID: 21329946.
    Citations: 25     Fields:    Translation:Animals
  124. Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J. Mitral valve endothelial cells with osteogenic differentiation potential. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):598-607. PMID: 21164078.
    Citations: 54     Fields:    Translation:AnimalsCells
  125. Gu JW, Halpin CF, Nam EC, Levine RA, Melcher JR. Tinnitus, diminished sound-level tolerance, and elevated auditory activity in humans with clinically normal hearing sensitivity. J Neurophysiol. 2010 Dec; 104(6):3361-70. PMID: 20881196.
    Citations: 106     Fields:    Translation:Humans
  126. Kim DH, Handschumacher MD, Levine RA, Choi YS, Kim YJ, Yun SC, Song JM, Kang DH, Song JK. In vivo measurement of mitral leaflet surface area and subvalvular geometry in patients with asymmetrical septal hypertrophy: insights into the mechanism of outflow tract obstruction. Circulation. 2010 Sep 28; 122(13):1298-307. PMID: 20837895.
    Citations: 23     Fields:    Translation:Humans
  127. Messas E, Bel A, Szymanski C, Cohen I, Touchot B, Handschumacher MD, Desnos M, Carpentier A, Menasché P, Hagège AA, Levine RA. Relief of mitral leaflet tethering following chronic myocardial infarction by chordal cutting diminishes left ventricular remodeling. Circ Cardiovasc Imaging. 2010 Nov; 3(6):679-86. PMID: 20826595.
    Citations: 13     Fields:    Translation:Animals
  128. Solis J, Levine RA, Johnson B, Guerrero JL, Handschumacher MD, Sullivan S, Lam K, Berlin J, Braithwaite GJ, Muratoglu OK, Vlahakes GJ, Hung J. Polymer injection therapy to reverse remodel the papillary muscles: efficacy in reducing mitral regurgitation in a chronic ischemic model. Circ Cardiovasc Interv. 2010 Oct; 3(5):499-505. PMID: 20736444.
    Citations: 8     Fields:    Translation:Animals
  129. Levine RA, Nattel S. Looking into the left atrial crystal ball: a ray of hope for patients with organic mitral regurgitation. J Am Coll Cardiol. 2010 Aug 10; 56(7):579-81. PMID: 20688213.
    Citations:    Fields:    Translation:Humans
  130. Beeri R, Chaput M, Guerrero JL, Kawase Y, Yosefy C, Abedat S, Karakikes I, Morel C, Tisosky A, Sullivan S, Handschumacher MD, Gilon D, Vlahakes GJ, Hajjar RJ, Levine RA. Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation. Circ Heart Fail. 2010 Sep; 3(5):627-34. PMID: 20634484.
    Citations: 27     Fields:    Translation:AnimalsCells
  131. Kubota K, Otsuji Y, Ueno T, Koriyama C, Levine RA, Sakata R, Tei C. Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion. J Thorac Cardiovasc Surg. 2010 Sep; 140(3):617-23. PMID: 20122701.
    Citations: 21     Fields:    Translation:Humans
  132. Yosefy C, Hung J, Chua S, Vaturi M, Ton-Nu TT, Handschumacher MD, Levine RA. Direct measurement of vena contracta area by real-time 3-dimensional echocardiography for assessing severity of mitral regurgitation. Am J Cardiol. 2009 Oct 01; 104(7):978-83. PMID: 19766767.
    Citations: 14     Fields:    Translation:Humans
  133. Solis J, McCarty D, Levine RA, Handschumacher MD, Fernandez-Friera L, Chen-Tournoux A, Mont L, Vidal B, Singh JP, Brugada J, Picard MH, Sitges M, Hung J. Mechanism of decrease in mitral regurgitation after cardiac resynchronization therapy: optimization of the force-balance relationship. Circ Cardiovasc Imaging. 2009 Nov; 2(6):444-50. PMID: 19920042.
    Citations: 17     Fields:    Translation:Humans
  134. Chaput M, Handschumacher MD, Guerrero JL, Holmvang G, Dal-Bianco JP, Sullivan S, Vlahakes GJ, Hung J, Levine RA. Mitral leaflet adaptation to ventricular remodeling: prospective changes in a model of ischemic mitral regurgitation. Circulation. 2009 Sep 15; 120(11 Suppl):S99-103. PMID: 19752393.
    Citations: 42     Fields:    Translation:Animals
  135. Melcher JR, Levine RA, Bergevin C, Norris B. The auditory midbrain of people with tinnitus: abnormal sound-evoked activity revisited. Hear Res. 2009 Nov; 257(1-2):63-74. PMID: 19699287.
    Citations: 47     Fields:    Translation:HumansPHPublic Health
  136. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A. Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. Circulation. 2009 Jul 28; 120(4):334-42. PMID: 19597052.
    Citations: 87     Fields:    Translation:Animals
  137. Chua S, Levine RA, Yosefy C, Handschumacher MD, Chu J, Qureshi A, Neary J, Ton-Nu TT, Fu M, Wu CJ, Hung J. Assessment of right ventricular function by real-time three-dimensional echocardiography improves accuracy and decreases interobserver variability compared with conventional two-dimensional views. Eur J Echocardiogr. 2009 Jul; 10(5):619-24. PMID: 19258335.
    Citations: 6     Fields:    Translation:Humans
  138. Yared K, Solis J, Passeri J, King ME, Levine RA. Three-dimensional echocardiographic assessment of acquired left ventricular to right atrial shunt (Gerbode defect). J Am Soc Echocardiogr. 2009 Apr; 22(4):435.e1-3. PMID: 19201573.
    Citations: 7     Fields:    Translation:Humans
  139. Solis J, Sitges M, Levine RA, Hung J. Three-dimensional echocardiography. New possibilities in mitral valve assessment. Rev Esp Cardiol. 2009 Feb; 62(2):188-98. PMID: 19232192.
    Citations: 4     Fields:    Translation:Humans
  140. Solis J, Sitges M, Levine RA, Hung J. Three-dimensional echocardiography. New possibilities in mitral valve assessment. Rev Esp Cardiol (Engl Ed). 2009 Feb; 62(2):188-98. PMID: 24774376.
    Citations:    
  141. Hung J, Solis J, Guerrero JL, Braithwaite GJ, Muratoglu OK, Chaput M, Fernandez-Friera L, Handschumacher MD, Wedeen VJ, Houser S, Vlahakes GJ, Levine RA. A novel approach for reducing ischemic mitral regurgitation by injection of a polymer to reverse remodel and reposition displaced papillary muscles. Circulation. 2008 Sep 30; 118(14 Suppl):S263-9. PMID: 18824765.
    Citations: 11     Fields:    Translation:Animals
  142. Jensen MO, Jensen H, Smerup M, Levine RA, Yoganathan AP, Nygaard H, Hasenkam JM, Nielsen SL. Saddle-shaped mitral valve annuloplasty rings experience lower forces compared with flat rings. Circulation. 2008 Sep 30; 118(14 Suppl):S250-5. PMID: 18824763.
    Citations: 37     Fields:    Translation:Animals
  143. Chaput M, Handschumacher MD, Tournoux F, Hua L, Guerrero JL, Vlahakes GJ, Levine RA. Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation. Circulation. 2008 Aug 19; 118(8):845-52. PMID: 18678770.
    Citations: 73     Fields:    Translation:HumansAnimals
  144. Chu JW, Levine RA, Chua S, Poh KK, Morris E, Hua L, Ton-Nu TT, Hung J. Assessing mitral valve area and orifice geometry in calcific mitral stenosis: a new solution by real-time three-dimensional echocardiography. J Am Soc Echocardiogr. 2008 Sep; 21(9):1006-9. PMID: 18620839.
    Citations: 10     Fields:    Translation:Humans
  145. Levine RA, Durst R. Mitral valve prolapse: a deeper look. JACC Cardiovasc Imaging. 2008 May; 1(3):304-6. PMID: 19225572.
    Citations: 2     Fields:    Translation:Humans
  146. Otsuji Y, Levine RA, Takeuchi M, Sakata R, Tei C. Mechanism of ischemic mitral regurgitation. J Cardiol. 2008 Jun; 51(3):145-56. PMID: 18522789.
    Citations: 15     Fields:    Translation:Humans
  147. Neilan TG, Ton-Nu TT, Kawase Y, Yoneyama R, Hoshino K, Del Monte F, Hajjar RJ, Picard MH, Levine RA, Hung J. Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2106-11. PMID: 18326805.
    Citations: 7     Fields: