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profileJan Leslie Shifren, M.D.

TitleVincent Trustees Professor of Obstetrics, Gynecology and Reproductive Biology
InstitutionMassachusetts General Hospital
DepartmentObstetrics Gynecology & Repro. Bio.
AddressMassachusetts General Hospital
Vincent Ob/Gyn Service, VBK 113
55 Fruit St
Boston MA 02114
Phone617/726-8868
Fax617/726-4803
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shifren JL, Davis SR. Androgens in postmenopausal women: a review. Menopause. 2017 Jun 12. PMID: 28609390.
    View in: PubMed
  2. Carpenter JS, Jones SM, Studts CR, Heiman JR, Reed SD, Newton KM, Guthrie KA, Larson JC, Cohen LS, Freeman EW, Jane Lau R, Learman LA, Shifren JL. Female Sexual Function Index Short Version: A MsFLASH Item Response Analysis. Arch Sex Behav. 2016 Nov; 45(8):1897-1905. PMID: 27502350.
    View in: PubMed
  3. Gass ML, Stuenkel CA, Utian WH, LaCroix A, Liu JH, Shifren JL. Use of compounded hormone therapy in the United States: report of The North American Menopause Society Survey. Menopause. 2015 Dec; 22(12):1276-84. PMID: 26382314.
    View in: PubMed
  4. Shifren JL. Testosterone for midlife women: the hormone of desire? Menopause. 2015 Oct; 22(10):1147-9. PMID: 26397145.
    View in: PubMed
  5. Gass ML, Maki PM, Shifren JL, Schnatz PF, Kaunitz AM, Shapiro M, Sievert LL. NAMS supports judicious use of systemic hormone therapy for women aged 65 years and older. Menopause. 2015 Jul; 22(7):685-6. PMID: 26035151.
    View in: PubMed
  6. Caan B, LaCroix AZ, Joffe H, Guthrie KA, Larson JC, Carpenter JS, Cohen LS, Freeman EW, Manson JE, Newton K, Reed S, Rexrode K, Shifren J, Sternfeld B, Ensrud K. Effects of estrogen and venlafaxine on menopause-related quality of life in healthy postmenopausal women with hot flashes: a placebo-controlled randomized trial. Menopause. 2015 Jun; 22(6):607-15. PMID: 25405571; PMCID: PMC4610378 [Available on 06/01/16].
  7. Carpenter JS, Reed SD, Guthrie KA, Larson JC, Newton KM, Lau RJ, Learman LA, Shifren JL. Using an FSDS-R Item to Screen for Sexually Related Distress: A MsFLASH Analysis. Sex Med. 2015 Mar; 3(1):7-13. PMID: 25844170; PMCID: PMC4380908.
  8. Manson JE, Ames JM, Shapiro M, Gass ML, Shifren JL, Stuenkel CA, Pinkerton JV, Kaunitz AM, Pace DT, Kagan R, Schnatz PF, Kingsberg SA, Liu JH, Joffe H, Richard-Davis G, Goldstein SR, Schiff I, Utian WH. Algorithm and mobile app for menopausal symptom management and hormonal/non-hormonal therapy decision making: a clinical decision-support tool from The North American Menopause Society. Menopause. 2015 Mar; 22(3):247-53. PMID: 25314150.
    View in: PubMed
  9. Ensrud KE, Guthrie KA, Hohensee C, Caan B, Carpenter JS, Freeman EW, LaCroix AZ, Landis CA, Manson J, Newton KM, Otte J, Reed SD, Shifren JL, Sternfeld B, Woods NF, Joffe H. Effects of estradiol and venlafaxine on insomnia symptoms and sleep quality in women with hot flashes. Sleep. 2015 Jan 01; 38(1):97-108. PMID: 25325454; PMCID: PMC4262961.
  10. Psaros C, Kagan L, Shifren JL, Willett J, Jacquart J, Alert MD, Macklin EA, Styer AK, Denninger JW, LaRoche KL, Park ER. Mind-body group treatment for women coping with infertility: a pilot study. J Psychosom Obstet Gynaecol. 2015; 36(2):75-83. PMID: 25541217.
    View in: PubMed
  11. Shifren JL, Gass ML. The North American Menopause Society recommendations for clinical care of midlife women. Menopause. 2014 Oct; 21(10):1038-62. PMID: 25225714.
    View in: PubMed
  12. Utian WH, Schiff I, Kronenberg F, Kronenberg F, Shifren JL, Gass ML. The North American Menopause Society at 25 years: celebrating our history and looking to the future. Menopause. 2014 Oct; 21(10):1029-31. PMID: 25093722.
    View in: PubMed
  13. Manson JE, Goldstein SR, Kagan R, Kaunitz AM, Liu JH, Pinkerton JV, Rebar RW, Schnatz PF, Shifren JL, Stuenkel CA, Gass ML, Utian WH. Why the product labeling for low-dose vaginal estrogen should be changed. Menopause. 2014 Sep; 21(9):911-6. PMID: 25140698.
    View in: PubMed
  14. Reed SD, Mitchell CM, Joffe H, Cohen L, Shifren JL, Newton KM, Freeman EW, Larson JC, Manson JE, LaCroix AZ, Guthrie KA. Sexual function in women on estradiol or venlafaxine for hot flushes: a randomized controlled trial. Obstet Gynecol. 2014 Aug; 124(2 Pt 1):233-41. PMID: 25004335; PMCID: PMC4113909.
  15. Joffe H, Guthrie KA, LaCroix AZ, Reed SD, Ensrud KE, Manson JE, Newton KM, Freeman EW, Anderson GL, Larson JC, Hunt J, Shifren J, Rexrode KM, Caan B, Sternfeld B, Carpenter JS, Cohen L. Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial. JAMA Intern Med. 2014 Jul; 174(7):1058-66. PMID: 24861828; PMCID: PMC4179877.
  16. Looby SE, Shifren J, Corless I, Rope A, Pedersen MC, Joffe H, Grinspoon S. Increased hot flash severity and related interference in perimenopausal human immunodeficiency virus-infected women. Menopause. 2014 Apr; 21(4):403-9. PMID: 23820600; PMCID: PMC3819412.
  17. Reed SD, Guthrie KA, Joffe H, Shifren JL, Seguin RA, Freeman EW. Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial. Obstet Gynecol. 2012 Mar; 119(3):527-38. PMID: 22353950; PMCID: PMC3345186.
  18. Rosen RC, Connor MK, Miyasato G, Link C, Shifren JL, Fisher WA, Derogatis LR, Schobelock MJ. Sexual desire problems in women seeking healthcare: a novel study design for ascertaining prevalence of hypoactive sexual desire disorder in clinic-based samples of U.S. women. J Womens Health (Larchmt). 2012 May; 21(5):505-15. PMID: 22229714.
    View in: PubMed
  19. Maserejian NN, Shifren J, Parish SJ, Segraves RT, Huang L, Rosen RC. Sexual arousal and lubrication problems in women with clinically diagnosed hypoactive sexual desire disorder: preliminary findings from the hypoactive sexual desire disorder registry for women. J Sex Marital Ther. 2012; 38(1):41-62. PMID: 22268981.
    View in: PubMed
  20. Shifren JL. Increasing our understanding of women's sexuality at midlife and beyond. Menopause. 2011 Nov; 18(11):1149-51. PMID: 21993079.
    View in: PubMed
  21. Maserejian NN, Parish S, Shifren JL, Huang L, Gerstenberger E, Rosen RC. Healthcare utilization in women diagnosed with hypoactive sexual desire disorder: interim baseline results from the HSDD Registry for Women. J Womens Health (Larchmt). 2010 Nov; 19(11):2001-9. PMID: 20929408.
    View in: PubMed
  22. Maserejian NN, Shifren JL, Parish SJ, Braunstein GD, Gerstenberger EP, Rosen RC. The presentation of hypoactive sexual desire disorder in premenopausal women. J Sex Med. 2010 Oct; 7(10):3439-48. PMID: 20646184.
    View in: PubMed
  23. Shifren JL, Schiff I. Role of hormone therapy in the management of menopause. Obstet Gynecol. 2010 Apr; 115(4):839-55. PMID: 20308847.
    View in: PubMed
  24. Wierman ME, Nappi RE, Avis N, Davis SR, Labrie F, Rosner W, Shifren JL. Endocrine aspects of women's sexual function. J Sex Med. 2010 Jan; 7(1 Pt 2):561-85. PMID: 20092453.
    View in: PubMed
  25. Johannes CB, Clayton AH, Odom DM, Rosen RC, Russo PA, Shifren JL, Monz BU. Distressing sexual problems in United States women revisited: prevalence after accounting for depression. J Clin Psychiatry. 2009 Dec; 70(12):1698-706. PMID: 20141709.
    View in: PubMed
  26. Shifren JL, Johannes CB, Monz BU, Russo PA, Bennett L, Rosen R. Help-seeking behavior of women with self-reported distressing sexual problems. J Womens Health (Larchmt). 2009 Apr; 18(4):461-8. PMID: 19361312.
    View in: PubMed
  27. Rosen RC, Shifren JL, Monz BU, Odom DM, Russo PA, Johannes CB. Correlates of sexually related personal distress in women with low sexual desire. J Sex Med. 2009 Jun; 6(6):1549-60. PMID: 19473457.
    View in: PubMed
  28. Shifren JL. Androgens, estrogens, and metabolic syndrome at midlife. Menopause. 2009 Mar-Apr; 16(2):226-8. PMID: 19179927.
    View in: PubMed
  29. Avis NE, Legault C, Coeytaux RR, Pian-Smith M, Shifren JL, Chen W, Valaskatgis P. A randomized, controlled pilot study of acupuncture treatment for menopausal hot flashes. Menopause. 2008 Nov-Dec; 15(6):1070-8. PMID: 18528313.
    View in: PubMed
  30. Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 2008 Nov; 112(5):970-8. PMID: 18978095.
    View in: PubMed
  31. Juve CL, Shifren JL. Treating older women. RN. 2008 Sep; 71(9):17-8, 20. PMID: 18833740.
    View in: PubMed
  32. Speroff L, Shifren JL. Experts offer advice on testosterone testing and whether to discontinue hormone therapy before surgery. Geriatrics. 2008 Aug; 63(8):2 p following 31. PMID: 18795461.
    View in: PubMed
  33. Shifren JL, Rifai N, Desindes S, McIlwain M, Doros G, Mazer NA. A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women. J Clin Endocrinol Metab. 2008 May; 93(5):1702-10. PMID: 18303079.
    View in: PubMed
  34. Shifren JL, Desindes S, McIlwain M, Doros G, Mazer NA. A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause. 2007 Nov-Dec; 14(6):985-94. PMID: 17507833.
    View in: PubMed
  35. Kingsberg S, Shifren J, Wekselman K, Rodenberg C, Koochaki P, Derogatis L. Evaluation of the clinical relevance of benefits associated with transdermal testosterone treatment in postmenopausal women with hypoactive sexual desire disorder. J Sex Med. 2007 Jul; 4(4 Pt 1):1001-8. PMID: 17627745.
    View in: PubMed
  36. Shifren JL, Avis NE. Surgical menopause: effects on psychological well-being and sexuality. Menopause. 2007 May-Jun; 14(3 Pt 2):586-91. PMID: 17476149.
    View in: PubMed
  37. Shifren JL, Davis SR, Moreau M, Waldbaum A, Bouchard C, DeRogatis L, Derzko C, Bearnson P, Kakos N, O'Neill S, Levine S, Wekselman K, Buch A, Rodenberg C, Kroll R. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause. 2006 Sep-Oct; 13(5):770-9. PMID: 16932240.
    View in: PubMed
  38. Chen Z, Hauser R, Trbovich AM, Shifren JL, Dorer DJ, Godfrey-Bailey L, Singh NP. The relationship between human semen characteristics and sperm apoptosis: a pilot study. J Androl. 2006 Jan-Feb; 27(1):112-20. PMID: 16400087.
    View in: PubMed
  39. Shifren JL. Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal women. Menopause. 2006 Jan-Feb; 13(1):8-9. PMID: 16607092.
    View in: PubMed
  40. Johnsen S, Dolan SE, Fitch KV, Killilea KM, Shifren JL, Grinspoon SK. Absence of polycystic ovary syndrome features in human immunodeficiency virus-infected women despite significant hyperinsulinemia and truncal adiposity. J Clin Endocrinol Metab. 2005 Oct; 90(10):5596-604. PMID: 16076939.
    View in: PubMed
  41. Braunstein GD, Sundwall DA, Katz M, Shifren JL, Buster JE, Simon JA, Bachman G, Aguirre OA, Lucas JD, Rodenberg C, Buch A, Watts NB. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med. 2005 Jul 25; 165(14):1582-9. PMID: 16043675.
    View in: PubMed
  42. Pritts EA, Ryan IP, Mueller MD, Lebovic DI, Shifren JL, Zaloudek CJ, Korn AP, Darney PD, Taylor RN. Angiogenic effects of norplant contraception on endometrial histology and uterine bleeding. J Clin Endocrinol Metab. 2005 Apr; 90(4):2142-7. PMID: 15623808.
    View in: PubMed
  43. Davis SR, Guay AT, Shifren JL, Mazer NA. Endocrine aspects of female sexual dysfunction. J Sex Med. 2004 Jul; 1(1):82-6. PMID: 16422987.
    View in: PubMed
  44. Shifren J, Ferrari NA. A better sex life. Newsweek. 2004 May 10; 143(19):86-7. PMID: 15164559.
    View in: PubMed
  45. Shifren JL. The role of androgens in female sexual dysfunction. Mayo Clin Proc. 2004 Apr; 79(4 Suppl):S19-24. PMID: 15065634.
    View in: PubMed
  46. Regestein QR, Friebely J, Shifren JL, Scharf MB, Wiita B, Carver J, Schiff I. Self-reported sleep in postmenopausal women. Menopause. 2004 Mar-Apr; 11(2):198-207. PMID: 15021450.
    View in: PubMed
  47. Shifren JL. Is there a role for testosterone therapy in premenopausal women? Menopause. 2003 Sep-Oct; 10(5):383-4. PMID: 14501596.
    View in: PubMed
  48. Shifren JL, Mazer NA. Safety profile of transdermal testosterone therapy in women. Am J Obstet Gynecol. 2003 Sep; 189(3):898-9; author reply 899. PMID: 14560750.
    View in: PubMed
  49. Cohen LS, Soares CN, Poitras JR, Prouty J, Alexander AB, Shifren JL. Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report. Am J Psychiatry. 2003 Aug; 160(8):1519-22. PMID: 12900318.
    View in: PubMed
  50. Mazer NA, Shifren JL. Transdermal testosterone for women: a new physiological approach for androgen therapy. Obstet Gynecol Surv. 2003 Jul; 58(7):489-500. PMID: 12832941.
    View in: PubMed
  51. Soares CN, Poitras JR, Prouty J, Alexander AB, Shifren JL, Cohen LS. Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms. J Clin Psychiatry. 2003 Apr; 64(4):473-9. PMID: 12716252.
    View in: PubMed
  52. Pinkerton JV, Shifren JL, La Valleur J, Rosen A, Roesinger M, Siddhanti S. Influence of raloxifene on the efficacy of an estradiol-releasing ring for treating vaginal atrophy in postmenopausal women. Menopause. 2003 Jan-Feb; 10(1):45-52. PMID: 12544676.
    View in: PubMed
  53. Bachmann G, Bancroft J, Braunstein G, Burger H, Davis S, Dennerstein L, Goldstein I, Guay A, Leiblum S, Lobo R, Notelovitz M, Rosen R, Sarrel P, Sherwin B, Simon J, Simpson E, Shifren J, Spark R, Traish A. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril. 2002 Apr; 77(4):660-5. PMID: 11937111.
    View in: PubMed
  54. Shifren JL. Androgen deficiency in the oophorectomized woman. Fertil Steril. 2002 Apr; 77 Suppl 4:S60-2. PMID: 12007904.
    View in: PubMed
  55. Regestein QR, Friebely J, Shifren J, Schiff I. Neuropsychological effects of methyltestosterone in women using menopausal hormone replacement. J Womens Health Gend Based Med. 2001 Sep; 10(7):671-6. PMID: 11571096.
    View in: PubMed
  56. Friebely JS, Shifren JL, Schiff I, Regestein QR. Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments. J Womens Health Gend Based Med. 2001 Mar; 10(2):181-7. PMID: 11268301.
    View in: PubMed
  57. Nahum R, Shifren JL, Chang Y, Leykin L, Isaacson K, Toth TL. Antral follicle assessment as a tool for predicting outcome in IVF--is it a better predictor than age and FSH? J Assist Reprod Genet. 2001 Mar; 18(3):151-5. PMID: 11411430; PMCID: PMC3455595.
  58. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med. 2000 Sep 07; 343(10):682-8. PMID: 10974131.
    View in: PubMed
  59. Lebovic DI, Shifren JL, Ryan IP, Mueller MD, Korn AP, Darney PD, Taylor RN. Ovarian steroid and cytokine modulation of human endometrial angiogenesis. Hum Reprod. 2000 Aug; 15 Suppl 3:67-77. PMID: 11041223.
    View in: PubMed
  60. Shifren JL, Schiff I. The aging ovary. J Womens Health Gend Based Med. 2000; 9 Suppl 1:S3-7. PMID: 10695867.
    View in: PubMed
  61. Segal S, Shifren JL, Isaacson KB, Leykin L, Chang Y, Pal L, Toth TL. Effect of a baseline ovarian cyst on the outcome of in vitro fertilization-embryo transfer. Fertil Steril. 1999 Feb; 71(2):274-7. PMID: 9988397.
    View in: PubMed
  62. Hornung D, Lebovic DI, Shifren JL, Vigne JL, Taylor RN. Vectorial secretion of vascular endothelial growth factor by polarized human endometrial epithelial cells. Fertil Steril. 1998 May; 69(5):909-15. PMID: 9591502.
    View in: PubMed
  63. Palumbo SK, Shifren J, Rhee C. Modifications of the Lejour vertical mammaplasty: analysis of results in 100 consecutive patients. Ann Plast Surg. 1998 Apr; 40(4):354-9. PMID: 9555988.
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  64. Shifren JL, Mesiano S, Taylor RN, Ferrara N, Jaffe RB. Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998 Apr; 83(4):1342-7. PMID: 9543165.
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  65. Pal L, Shifren JL, Isaacson KB, Chang Y, Leykin L, Toth TL. Impact of varying stages of endometriosis on the outcome of in vitro fertilization-embryo transfer. J Assist Reprod Genet. 1998 Jan; 15(1):27-31. PMID: 9493063; PMCID: PMC3468198.
  66. Baker VL, Draper M, Paul S, Allerheiligen S, Glant M, Shifren J, Jaffe RB. Reproductive endocrine and endometrial effects of raloxifene hydrochloride, a selective estrogen receptor modulator, in women with regular menstrual cycles. J Clin Endocrinol Metab. 1998 Jan; 83(1):6-13. PMID: 9435408.
    View in: PubMed
  67. Shifren JL, Nahum R, Mazer NA. Incidence of sexual dysfunction in surgically menopausal women. Menopause. 1998; 5(3):189-90. PMID: 9774766.
    View in: PubMed
  68. Pal L, Shifren JL, Isaacson KB, Chang Y, Marean M, Leykin L, Toth TL. Outcome of IVF in DES-exposed daughters: experience in the 90s. J Assist Reprod Genet. 1997 Oct; 14(9):513-7. PMID: 9401869; PMCID: PMC3454843.
  69. Taylor RN, Ryan IP, Moore ES, Hornung D, Shifren JL, Tseng JF. Angiogenesis and macrophage activation in endometriosis. Ann N Y Acad Sci. 1997 Sep 26; 828:194-207. PMID: 9329840.
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  70. Tao XJ, Tilly KI, Maravei DV, Shifren JL, Krajewski S, Reed JC, Tilly JL, Isaacson KB. Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cell apoptosis is associated with increased expression of bax. J Clin Endocrinol Metab. 1997 Aug; 82(8):2738-46. PMID: 9253363.
    View in: PubMed
  71. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996 Aug; 81(8):3112-8. PMID: 8768883.
    View in: PubMed
  72. Gordon JD, Shifren JL, Foulk RA, Taylor RN, Jaffe RB. Angiogenesis in the human female reproductive tract. Obstet Gynecol Surv. 1995 Sep; 50(9):688-97. PMID: 7478421.
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  73. Shifren JL, Doldi N, Ferrara N, Mesiano S, Jaffe RB. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action. J Clin Endocrinol Metab. 1994 Jul; 79(1):316-22. PMID: 8027247.
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  74. Shifren JL, Osathanondh R, Yeh J. Human fetal ovaries and uteri: developmental expression of genes encoding the insulin, insulin-like growth factor I, and insulin-like growth factor II receptors. Fertil Steril. 1993 May; 59(5):1036-40. PMID: 8486170.
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  75. Shifren JL, Adlestein L, Finkler NJ. Asystolic cardiac arrest: a rare complication of laparoscopy. Obstet Gynecol. 1992 May; 79(5 ( Pt 2)):840-1. PMID: 1533024.
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  76. Greenberg JA, Sorem KA, Shifren JL, Riley LE. Placenta membranacea with placenta increta: a case report and literature review. Obstet Gynecol. 1991 Sep; 78(3 Pt 2):512-4. PMID: 1870811.
    View in: PubMed
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