Harvard Catalyst Profiles

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Rami Burstein, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS094198 (BURSTEIN, RAMI) Jul 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Cortical Mechanisms of Headache: Beyond CSD
    Role: Principal Investigator
  2. R37NS079678 (BURSTEIN, RAMI) Jul 1, 2012 - Jun 30, 2019
    NIH/NINDS
    Photophobia during migraine: sensory, autonomic and emotional responses to light
    Role: Principal Investigator
  3. R01NS069847 (BURSTEIN, RAMI) Feb 1, 2010 - Jan 31, 2015
    NIH/NINDS
    Migraine pathophysiology: neural basis of photophobia
    Role: Principal Investigator
  4. R01NS051484 (BURSTEIN, RAMI) Jun 1, 2005 - Mar 31, 2011
    NIH/NINDS
    Migraine Pathophysiology:Thalamus and Extended Allodynia
    Role: Principal Investigator
  5. R01DE013347 (BURSTEIN, RAMI) Apr 1, 2000 - Mar 31, 2005
    NIH/NIDCR
    NEUROBIOLOGY OF ANOREXIA INDUCED BY MIGRAINE PAIN
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yarnitsky D, Dodick DW, Grosberg BM, Burstein R, Ironi A, Harris D, Lin T, Silberstein SD. Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. Headache. 2019 May 09. PMID: 31074005.
    Citations:    
  2. Bishop J, Becerra L, Barmettler G, Chang PC, Kainz V, Burstein R, Borsook D. Modulation of Brain Networks by Sumatriptan-Naproxen in the Inflammatory-Soup Migraine Model. Pain. 2019 Apr 24. PMID: 31033778.
    Citations:    
  3. Colon E, Ludwick A, Wilcox SL, Youssef AM, Danehy A, Fair DA, Lebel AA, Burstein R, Becerra L, Borsook D. Migraine in the Young Brain: Adolescents vs. Young Adults. Front Hum Neurosci. 2019; 13:87. PMID: 30967767.
    Citations:    
  4. Burstein R, Noseda R, Fulton AB. Neurobiology of Photophobia. J Neuroophthalmol. 2019 Mar; 39(1):94-102. PMID: 30762717.
    Citations:    
  5. Bernstein CA, Nir RR, Noseda R, Fulton AB, Huntington S, Lee AJ, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2019 Mar; 160(3):569-578. PMID: 30376534.
    Citations:    Fields:    
  6. Noseda R, Melo-Carrillo A, Nir RR, Strassman AM, Burstein R. Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache. J Neurosci. 2019 Mar 06; 39(10):1867-1880. PMID: 30622169.
    Citations:    Fields:    
  7. Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034. PMID: 29905657.
    Citations:    Fields:    
  8. Blake P, Nir RR, Perry CJ, Burstein R. Tracking patients with chronic occipital headache after occipital nerve decompression surgery: A case series. Cephalalgia. 2019 Apr; 39(4):556-563. PMID: 30217120.
    Citations:    Fields:    
  9. Platzbecker K, Zhang MB, Kurth T, Rudolph MI, Eikermann-Haerter K, Burstein R, Eikermann M, Houle T. The association between migraine and hospital readmission due to pain after surgery: A hospital registry study. Cephalalgia. 2019 Feb; 39(2):286-295. PMID: 29984600.
    Citations:    Fields:    
  10. Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 Mar; 83(3):508-521. PMID: 29394508.
    Citations: 1     Fields:    
  11. Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. PMID: 29487563.
    Citations:    
  12. Noseda R, Copenhagen D, Burstein R. Current understanding of photophobia, visual networks and headaches. Cephalalgia. 2018 Jan 01; 333102418784750. PMID: 29940781.
    Citations: 1     Fields:    
  13. Melo-Carrillo A, Strassman AM, Nir RR, Schain AJ, Noseda R, Stratton J, Burstein R. Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017 11 01; 37(44):10587-10596. PMID: 28972120.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Noseda R, Lee AJ, Nir RR, Bernstein CA, Kainz VM, Bertisch SM, Buettner C, Borsook D, Burstein R. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692. PMID: 28652355.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R. Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017 07 26; 37(30):7149-7163. PMID: 28642283.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Lipton RB, Munjal S, Buse DC, Bennett A, Fanning KM, Burstein R, Reed ML. Allodynia Is Associated With Initial and Sustained Response to Acute Migraine Treatment: Results from the American Migraine Prevalence and Prevention Study. Headache. 2017 Jul; 57(7):1026-1040. PMID: 28603893.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  17. Burstein R, Blake P, Schain A, Perry C. Extracranial origin of headache. Curr Opin Neurol. 2017 06; 30(3):263-271. PMID: 28248698.
    Citations:    Fields:    Translation:Humans
  18. Youssef AM, Ludwick A, Wilcox SL, Lebel A, Peng K, Colon E, Danehy A, Burstein R, Becerra L, Borsook D. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. PMID: 28560777.
    Citations: 4     Fields:    Translation:Humans
  19. Noseda R, Borsook D, Burstein R. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111. PMID: 28485844.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Buettner C, Melo-Carrillo A, Burstein R. Terminating Migraine-Associated Allodynia Using Oral Suspension Diclofenac: A Prospective Non-Randomized Drug Trial. Headache. 2017 03; 57(3):478-486. PMID: 28225188.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  21. Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci. 2017 03 15; 37(11):2904-2915. PMID: 28193695.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Becerra L, Bishop J, Barmettler G, Kainz V, Burstein R, Borsook D. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 04 01; 1660:36-46. PMID: 28167076.
    Citations: 3     Fields:    Translation:Animals
  23. Hodkinson DJ, Veggeberg R, Kucyi A, van Dijk KR, Wilcox SL, Scrivani SJ, Burstein R, Becerra L, Borsook D. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28101529.
    Citations: 3     Fields:    Translation:Humans
  24. Burstein R. Reply: Pupil area and photopigment spectral sensitivity are relevant to study of migraine photophobia. Brain. 2017 01; 140(1):e3. PMID: 28031225.
    Citations:    Fields:    Translation:HumansCells
  25. Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. PMID: 27766076.
    Citations: 6     
  26. Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36. PMID: 27466345.
    Citations: 6     Fields:    Translation:Humans
  27. Wilcox SL, Veggeberg R, Lemme J, Hodkinson DJ, Scrivani S, Burstein R, Becerra L, Borsook D. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. PMID: 27507939.
    Citations: 6     
  28. Noseda R, Bernstein CA, Nir RR, Lee AJ, Fulton AB, Bertisch SM, Hovaguimian A, Cestari DM, Saavedra-Walker R, Borsook D, Doran BL, Buettner C, Burstein R. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86. PMID: 27190022.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Perry CJ, Blake P, Buettner C, Papavassiliou E, Schain AJ, Bhasin MK, Burstein R. Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache. Ann Neurol. 2016 06; 79(6):1000-13. PMID: 27091721.
    Citations: 6     Fields:    Translation:Humans
  30. Becerra L, Veggeberg R, Prescot A, Jensen JE, Renshaw P, Scrivani S, Spierings ELH, Burstein R, Borsook D. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-594. PMID: 27158591.
    Citations: 2     Fields:    Translation:Humans
  31. Zhang X, Strassman AM, Novack V, Brin MF, Burstein R. Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? Cephalalgia. 2016 Aug; 36(9):875-86. PMID: 26984967.
    Citations: 5     Fields:    Translation:AnimalsCells
  32. Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA, Burstein R. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015 Dec; 78(6):970-81. PMID: 26418341.
    Citations: 8     Fields:    Translation:Humans
  33. Faria V, Erpelding N, Lebel A, Johnson A, Wolff R, Fair D, Burstein R, Becerra L, Borsook D. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-21. PMID: 26172552.
    Citations: 8     Fields:    Translation:Humans
  34. Bigal ME, Edvinsson L, Rapoport AM, Lipton RB, Spierings EL, Diener HC, Burstein R, Loupe PS, Ma Y, Yang R, Silberstein SD. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1091-100. PMID: 26432181.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
  35. Bigal ME, Dodick DW, Rapoport AM, Silberstein SD, Ma Y, Yang R, Loupe PS, Burstein R, Newman LC, Lipton RB. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1081-90. PMID: 26432182.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  36. Hodkinson DJ, Veggeberg R, Wilcox SL, Scrivani S, Burstein R, Becerra L, Borsook D. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. PMID: 26372461.
    Citations: 8     Fields:    Translation:Humans
  37. Borsook D, Veggeberg R, Erpelding N, Borra R, Linnman C, Burstein R, Becerra L. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 12; 22(6):632-652. PMID: 26290446.
    Citations: 12     Fields:    Translation:HumansAnimals
  38. Maleki N, Barmettler G, Moulton EA, Scrivani S, Veggeberg R, Spierings EL, Burstein R, Becerra L, Borsook D. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-9. PMID: 25775358.
    Citations: 2     Fields:    Translation:Humans
  39. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29. PMID: 25926442.
    Citations: 35     Fields:    Translation:HumansCells
  40. Buettner C, Burstein R. Association of statin use and risk for severe headache or migraine by serum vitamin D status: a cross-sectional population-based study. Cephalalgia. 2015 Aug; 35(9):757-66. PMID: 25424706.
    Citations: 6     Fields:    Translation:Humans
  41. Barmettler G, Brawn J, Maleki N, Scrivani S, Burstein R, Becerra L, Borsook D. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. PMID: 25143550.
    Citations: 3     Fields:    Translation:Humans
  42. Noseda R, Kainz V, Borsook D, Burstein R. Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929. PMID: 25090640.
    Citations: 16     Fields:    Translation:AnimalsCells
  43. Files JA, Schwedt TJ, Mayer AP, David PS, Vargas BB, Chang YH, Hunt M, Patel S, Ko MG, Tozer BS, Burstein R, Dodick DW. Imploding and exploding migraine headaches: comparison of methods to diagnose pain directionality. Headache. 2014 Jun; 54(6):1010-8. PMID: 24527766.
    Citations: 1     Fields:    Translation:Humans
  44. Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. PMID: 24743801.
    Citations: 21     Fields:    Translation:Humans
  45. Burstein R, Zhang X, Levy D, Aoki KR, Brin MF. Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69. PMID: 24694964.
    Citations: 33     Fields:    Translation:AnimalsCells
  46. Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant PE, Buettner C, Becerra L, Burstein R. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. PMID: 24662368.
    Citations: 10     Fields:    Translation:HumansAnimals
  47. Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, Burstein R. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med. 2014 Jan 08; 6(218):218ra5. PMID: 24401940.
    Citations: 44     Fields:    Translation:Humans
  48. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013 Dec; 154 Suppl 1. PMID: 24347803.
    Citations: 23     Fields:    
  49. Borsook D, Aasted CM, Burstein R, Becerra L. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. PMID: 24047609.
    Citations: 7     Fields:    Translation:Humans
  50. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013 Dec; 154 Suppl 1:S44-53. PMID: 23891892.
    Citations: 72     Fields:    Translation:HumansAnimals
  51. Kagan R, Kainz V, Burstein R, Noseda R. Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia. Neuroscience. 2013 Sep 17; 248:359-68. PMID: 23806720.
    Citations: 17     Fields:    Translation:AnimalsCells
  52. Strassman AM, Burstein R. A new animal model of headache: Ongoing pain vs stimulus-evoked hypersensitivity. Cephalalgia. 2013 Oct; 33(13):1073-4. PMID: 23766356.
    Citations: 2     Fields:    Translation:Animals
  53. Zhang X, Jakubowski M, Buettner C, Kainz V, Gold M, Burstein R. Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression. Epilepsy Behav. 2013 Aug; 28(2):243-8. PMID: 23562239.
    Citations: 2     Fields:    Translation:AnimalsCells
  54. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. PMID: 22843414.
    Citations: 38     Fields:    Translation:Humans
  55. Borsook D, Burstein R. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12. PMID: 22798640.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  56. Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. PMID: 22760159.
    Citations: 36     Fields:    Translation:Humans
  57. Bernstein C, Burstein R. Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012 Jun; 8(2):89-99. PMID: 22787491.
    Citations: 56     
  58. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. PMID: 22623760.
    Citations: 43     Fields:    Translation:Humans
  59. Burstein R, Strassman A, Moskowitz M. Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia. 2012 Apr; 32(6):509-11. PMID: 22345633.
    Citations: 5     Fields:    Translation:AnimalsCells
  60. Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72. PMID: 22144718.
    Citations: 15     Fields:    Translation:AnimalsCells
  61. Levy D, Moskowitz MA, Noseda R, Burstein R. Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2. PMID: 21996564.
    Citations: 3     Fields:    Translation:Animals
  62. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552.
    Citations: 30     Fields:    Translation:AnimalsCells
  63. Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17. PMID: 21976505.
    Citations: 36     Fields:    Translation:AnimalsCells
  64. Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. PMID: 21936901.
    Citations: 38     Fields:    Translation:Humans
  65. Noseda R, Burstein R. Advances in understanding the mechanisms of migraine-type photophobia. Curr Opin Neurol. 2011 Jun; 24(3):197-202. PMID: 21467933.
    Citations: 23     Fields:    Translation:HumansAnimals
  66. Levy D, Burstein R. The vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1. PMID: 21520229.
    Citations: 8     Fields:    Translation:HumansCells
  67. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65. PMID: 21416489.
    Citations: 66     Fields:    Translation:AnimalsCells
  68. Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. PMID: 21337474.
    Citations: 21     Fields:    Translation:Humans
  69. Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res. 2011; 21(6):305-14. PMID: 22348935.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  70. Burstein R, Kim CC, Dover JS, Arndt KA. Botulinum toxin type a headache treatment and entrapment of the supratrochlear nerve-reply. Arch Dermatol. 2010 Nov 15; 146(11):1311. PMID: 22637178.
    Citations:    
  71. Zhang XC, Kainz V, Burstein R, Levy D. Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-9. PMID: 21036476.
    Citations: 33     Fields:    Translation:AnimalsCells
  72. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. PMID: 20582997.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  73. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14. PMID: 20592202.
    Citations: 78     Fields:    Translation:AnimalsCells
  74. Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. PMID: 20562317.
    Citations: 54     Fields:    Translation:Humans
  75. Simopoulos T, Bajwa Z, Lantz G, Lee S, Burstein R. Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine. Headache. 2010 Jun; 50(6):1064-9. PMID: 20618819.
    Citations: 6     Fields:    Translation:Humans
  76. Kim CC, Bogart MM, Wee SA, Burstein R, Arndt KA, Dover JS. Predicting migraine responsiveness to botulinum toxin type A injections. Arch Dermatol. 2010 Feb; 146(2):159-63. PMID: 20157026.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  77. Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb; 13(2):239-45. PMID: 20062053.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  78. Burstein R, Jakubowski M. Managing migraine associated with sensitization. Handb Clin Neurol. 2010; 97:207-15. PMID: 20816422.
    Citations: 6     Fields:    Translation:HumansCells
  79. Kosaras B, Jakubowski M, Kainz V, Burstein R. Sensory innervation of the calvarial bones of the mouse. J Comp Neurol. 2009 Jul 20; 515(3):331-48. PMID: 19425099.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  80. Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol. 2009 Jul; 8(7):679-90. PMID: 19539239.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  81. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. PMID: 19566960.
    Citations: 22     Fields:    Translation:Humans
  82. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    Citations: 21     Fields:    Translation:HumansCells
  83. Burstein R, Jakubowski M. Neural substrate of depression during migraine. Neurol Sci. 2009 May; 30 Suppl 1:S27-31. PMID: 19415422.
    Citations: 7     Fields:    Translation:Humans
  84. Aurora SK, Barrodale PM, McDonald SA, Jakubowski M, Burstein R. Revisiting the efficacy of sumatriptan therapy during the aura phase of migraine. Headache. 2009 Jul; 49(7):1001-4. PMID: 19438735.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  85. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941.
    Citations: 8     Fields:    Translation:AnimalsCells
  86. Burstein R. Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia? Headache. 2009 Mar; 49(3):364-5. PMID: 19267784.
    Citations: 1     Fields:    Translation:Humans
  87. Burstein R, Dodick D, Silberstein S. Migraine prophylaxis with botulinum toxin A is associated with perception of headache. Toxicon. 2009 Oct; 54(5):624-7. PMID: 19344670.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  88. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. PMID: 19030105.
    Citations: 56     Fields:    Translation:HumansCells
  89. Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. Cutaneous allodynia in the migraine population. Ann Neurol. 2008 Feb; 63(2):148-58. PMID: 18059010.
    Citations: 85     Fields:    Translation:HumansCells
  90. Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22. PMID: 18333963.
    Citations: 12     Fields:    Translation:AnimalsCells
  91. Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83. PMID: 17651900.
    Citations: 14     Fields:    Translation:AnimalsCells
  92. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    Citations: 41     Fields:    Translation:AnimalsCells
  93. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586.
    Citations: 85     Fields:    Translation:AnimalsCells
  94. Jakubowski M, McAllister PJ, Bajwa ZH, Ward TN, Smith P, Burstein R. Exploding vs. imploding headache in migraine prophylaxis with Botulinum Toxin A. Pain. 2006 Dec 05; 125(3):286-95. PMID: 17069972.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  95. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    Citations: 17     Fields:    Translation:HumansCells
  96. Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. PMID: 16927962.
    Citations: 7     Fields:    Translation:Humans
  97. Burstein R, Jakubowski M. Unitary hypothesis for multiple triggers of the pain and strain of migraine. J Comp Neurol. 2005 Dec 05; 493(1):9-14. PMID: 16258903.
    Citations: 45     Fields:    Translation:HumansCells
  98. Jakubowski M, Silberstein S, Ashkenazi A, Burstein R. Can allodynic migraine patients be identified interictally using a questionnaire? Neurology. 2005 Nov 08; 65(9):1419-22. PMID: 16275830.
    Citations: 28     Fields:    Translation:HumansCells
  99. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    Citations: 57     Fields:    Translation:AnimalsCells
  100. Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61. PMID: 15985101.
    Citations: 47     Fields:    Translation:HumansAnimalsCTClinical Trials
  101. Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60. PMID: 16141951.
    Citations: 25     Fields:    Translation:HumansCells
  102. Burstein R, Jakubowski M. Implications of multimechanism therapy: when to treat? Neurology. 2005 May 24; 64(10 Suppl 2):S16-20. PMID: 15911782.
    Citations: 5     Fields:    Translation:HumansAnimals
  103. Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8. PMID: 15836966.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  104. Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. PMID: 15362156.
    Citations: 16     Fields:    Translation:Humans
  105. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9. PMID: 15016917.
    Citations: 57     Fields:    Translation:AnimalsCells
  106. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004 Jan; 55(1):27-36. PMID: 14705109.
    Citations: 78     Fields:    Translation:AnimalsCells
  107. Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004 Jan; 55(1):19-26. PMID: 14705108.
    Citations: 111     Fields:    Translation:Humans
  108. Yarnitsky D, Goor-Aryeh I, Bajwa ZH, Ransil BI, Cutrer FM, Sottile A, Burstein R. 2003 Wolff Award: Possible parasympathetic contributions to peripheral and central sensitization during migraine. Headache. 2003 Jul-Aug; 43(7):704-14. PMID: 12890124.
    Citations: 20     Fields:    Translation:HumansCells
  109. Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9930-5. PMID: 11504950.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  110. Burstein R. Deconstructing migraine headache into peripheral and central sensitization. Pain. 2001 Jan; 89(2-3):107-10. PMID: 11166465.
    Citations: 74     Fields:    Translation:Humans
  111. Malick A, Strassman RM, Burstein R. Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat. J Neurophysiol. 2000 Oct; 84(4):2078-112. PMID: 11024099.
    Citations: 32     Fields:    Translation:AnimalsCells
  112. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000 Aug; 123 ( Pt 8):1703-9. PMID: 10908199.
    Citations: 135     Fields:    Translation:Humans
  113. Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000 May; 47(5):614-24. PMID: 10805332.
    Citations: 199     Fields:    Translation:HumansCells
  114. Malick A, Burstein R. Peripheral and central sensitization during migraine. Funct Neurol. 2000; 15 Suppl 3:28-35. PMID: 11200798.
    Citations: 18     Fields:    Translation:Animals
  115. Yamamura H, Malick A, Chamberlin NL, Burstein R. Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. J Neurophysiol. 1999 Feb; 81(2):479-93. PMID: 10036252.
    Citations: 22     Fields:    Translation:AnimalsCells
  116. Malick A, Burstein R. Cells of origin of the trigeminohypothalamic tract in the rat. J Comp Neurol. 1998 Oct 12; 400(1):125-44. PMID: 9762871.
    Citations: 23     Fields:    Translation:AnimalsCells
  117. Burstein R, Yamamura H, Malick A, Strassman AM. Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons. J Neurophysiol. 1998 Feb; 79(2):964-82. PMID: 9463456.
    Citations: 131     Fields:    Translation:AnimalsCells
  118. Strassman AM, Raymond SA, Burstein R. Sensitization of meningeal sensory neurons and the origin of headaches. Nature. 1996 Dec 12; 384(6609):560-4. PMID: 8955268.
    Citations: 140     Fields:    Translation:AnimalsCells
  119. Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. PMID: 8889944.
    Citations: 3     Fields:    Translation:AnimalsCells
  120. Burstein R. Somatosensory and visceral input to the hypothalamus and limbic system. Prog Brain Res. 1996; 107:257-67. PMID: 8782524.
    Citations: 2     Fields:    Translation:Animals
  121. Fields HL, Malick A, Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol. 1995 Oct; 74(4):1742-59. PMID: 8989409.
    Citations: 36     Fields:    Translation:AnimalsCells
  122. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. PMID: 8152426.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  123. Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. PMID: 8294956.
    Citations: 13     Fields:    Translation:AnimalsCells
  124. Burstein R, Potrebic S. Retrograde labeling of neurons in the spinal cord that project directly to the amygdala or the orbital cortex in the rat. J Comp Neurol. 1993 Sep 22; 335(4):469-85. PMID: 8227531.
    Citations: 12     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.