Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Rami Burstein, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01NS094198 (BURSTEIN, RAMI) Jul 1, 2016 - Apr 30, 2021
    NIH
    Cortical Mechanisms of Headache: Beyond CSD
    Role: Principal Investigator
  2. R37NS079678 (BURSTEIN, RAMI) Jul 1, 2012 - Jun 30, 2021
    NIH
    Photophobia during migraine: sensory, autonomic and emotional responses to light
    Role: Principal Investigator
  3. R01NS069847 (BURSTEIN, RAMI) Feb 1, 2010 - Jan 31, 2015
    NIH
    Migraine pathophysiology: neural basis of photophobia
    Role: Principal Investigator
  4. R01NS051484 (BURSTEIN, RAMI) Jun 1, 2005 - Mar 31, 2011
    NIH
    Migraine Pathophysiology:Thalamus and Extended Allodynia
    Role: Principal Investigator
  5. R01DE013347 (BURSTEIN, RAMI) Apr 1, 2000 - Mar 31, 2005
    NIH
    NEUROBIOLOGY OF ANOREXIA INDUCED BY MIGRAINE PAIN
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ashina S, Melo-Carrillo A, Szabo E, Borsook D, Burstein R. Pre-treatment non-ictal cephalic allodynia identifies responders to prophylactic treatment of chronic and episodic migraine patients with galcanezumab: A prospective quantitative sensory testing study (NCT04271202). Cephalalgia. 2023 03; 43(3):3331024221147881. PMID: 36786278.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  2. Melo-Carrillo A, Rodriguez R, Ashina S, Lipinski B, Hart P, Burstein R. Psychotherapy Treatment of Generalized Anxiety Disorder Improves When Conducted Under Narrow Band Green Light. Psychol Res Behav Manag. 2023; 16:241-250. PMID: 36726697; PMCID: PMC9885775.
    Citations:    
  3. Ashina S, Bendtsen L, Burstein R, Iljazi A, Jensen RH, Lipton RB. Pain sensitivity in relation to frequency of migraine and tension-type headache with or without coexistent neck pain: an exploratory secondary analysis of the population study. Scand J Pain. 2023 01 27; 23(1):76-87. PMID: 36137215.
    Citations:    Fields:    Translation:Humans
  4. Lipton RB, Dodick DW, Goadsby PJ, Burstein R, Adams AM, Lai J, Yu SY, Finnegan M, Kuang AW, Trugman JM. Efficacy of Ubrogepant in the Acute Treatment of Migraine With Mild Pain vs Moderate or Severe Pain. Neurology. 2022 10 25; 99(17):e1905-e1915. PMID: 35977836; PMCID: PMC9620813.
    Citations:    Fields:    Translation:Humans
  5. Gfrerer L, Xu W, Austen W, Ashina S, Melo-Carrillo A, Longhi MS, Adams AM, Houle T, Brin MF, Burstein R. OnabotulinumtoxinA alters inflammatory gene expression and immune cells in chronic headache patients. Brain. 2022 07 29; 145(7):2436-2449. PMID: 34932787; PMCID: PMC9337807.
    Citations:    Fields:    
  6. Burstein R, Charway-Felli A. Board Walk - July 2022. Cephalalgia. 2022 Apr 25; 3331024221096337. PMID: 35469477.
    Citations:    Fields:    
  7. Strassman AM, Melo-Carrillo A, Houle TT, Adams A, Brin MF, Burstein R. Atogepant - an orally-administered CGRP antagonist - attenuates activation of meningeal nociceptors by CSD. Cephalalgia. 2022 08; 42(9):933-943. PMID: 35332801; PMCID: PMC9329220.
    Citations:    Fields:    Translation:AnimalsCells
  8. Stovner LJ, Hagen K, Tronvik E, Bruvik Gravdahl G, Burstein R, Dodick DW. FollowTheSutures: Piloting a new way to administer onabotulinumtoxinA for chronic migraine. Cephalalgia. 2022 06; 42(7):590-597. PMID: 35166150; PMCID: PMC9109235.
    Citations: 1     Fields:    Translation:Humans
  9. Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A, Ashina M, van den Maagdenberg AMJM, Dodick DW. Migraine. Nat Rev Dis Primers. 2022 01 13; 8(1):2. PMID: 35027572.
    Citations: 3     Fields:    Translation:Humans
  10. Melo-Carrillo A, Strassman AM, Schain AJ, Broide RS, Cai BB, Rhéaume C, Brideau-Andersen AD, Ashina S, Flores-Montanez Y, Brin MF, Burstein R. OnabotulinumtoxinA affects cortical recovery period but not occurrence or propagation of cortical spreading depression in rats with compromised blood-brain barrier. Pain. 2021 09 01; 162(9):2418-2427. PMID: 34448754.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Szabo E, Green S, Karunakaran KD, Sieberg CB, Elman I, Burstein R, Borsook D. Migraine: interactions between brain's trait and state. CNS Spectr. 2022 10; 27(5):561-569. PMID: 34308820; PMCID: PMC8688585.
    Citations:    Fields:    
  12. Lipton RB, Burstein R, Buse DC, Dodick DW, Koukakis R, Klatt J, Cheng S, Chou DE. Efficacy of erenumab in chronic migraine patients with and without ictal allodynia. Cephalalgia. 2021 10; 41(11-12):1152-1160. PMID: 33982623.
    Citations: 2     Fields:    Translation:Humans
  13. Lemme J, Holmes S, Sibai D, Mari J, Simons LE, Burstein R, Zurakowski D, Lebel A, O'Brien M, Upadhyay J, Borsook D. Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth. J Neurotrauma. 2021 06 15; 38(12):1632-1641. PMID: 33183144; PMCID: PMC8165471.
    Citations: 2     Fields:    Translation:Humans
  14. Maleki N, Szabo E, Becerra L, Moulton E, Scrivani SJ, Burstein R, Borsook D. Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia. PLoS One. 2021; 16(1):e0244320. PMID: 33395413.
    Citations: 3     Fields:    Translation:Humans
  15. Melo-Carrillo A, Strassman AM, Schain AJ, Adams AM, Brin MF, Burstein R. Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons. Cephalalgia. 2021 01; 41(1):17-32. PMID: 33200944; PMCID: PMC7786391.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Lehman LL, Bruccoleri R, Danehy A, Swanson J, Mrakotsky C, Smith E, Orbach DB, Burstein R. Adverse effects of erenumab on cerebral proliferative angiopathy: A case report. Cephalalgia. 2021 01; 41(1):122-126. PMID: 32814432.
    Citations: 1     Fields:    Translation:Humans
  17. Burstein R, Blumenfeld AM, Silberstein SD, Manack Adams A, Brin MF. Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review. Headache. 2020 07; 60(7):1259-1272. PMID: 32602955; PMCID: PMC7496564.
    Citations: 20     Fields:    Translation:Humans
  18. Melo-Carrillo A, Schain AJ, Strassman AM, Burstein R. Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache. J Neurosci. 2020 07 01; 40(27):5314-5326. PMID: 32527981.
    Citations:    Fields:    Translation:AnimalsCells
  19. Pellesi L, Do TP, Ashina H, Ashina M, Burstein R. Dual Therapy With Anti-CGRP Monoclonal Antibodies and Botulinum Toxin for Migraine Prevention: Is There a Rationale? Headache. 2020 06; 60(6):1056-1065. PMID: 32437038.
    Citations: 12     Fields:    Translation:HumansAnimals
  20. Melo-Carrillo A, Schain AJ, Stratton J, Strassman AM, Burstein R. Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier. Pain. 2020 05; 161(5):1037-1043. PMID: 31895266.
    Citations: 5     Fields:    Translation:Animals
  21. Schain AJ, Melo-Carrillo A, Ashina S, Strassman AM, Burstein R. Celecoxib reduces cortical spreading depression-induced macrophage activation and dilatation of dural but not pial arteries in rodents: implications for mechanism of action in terminating migraine attacks. Pain. 2020 05; 161(5):1019-1026. PMID: 31895267; PMCID: PMC7166151.
    Citations: 2     Fields:    Translation:Animals
  22. Iljazi A, Ashina H, Lipton RB, Chaudhry B, Al-Khazali HM, Naples JG, Schytz HW, Vukovic Cvetkovic V, Burstein R, Ashina S. Dizziness and vertigo during the prodromal phase and headache phase of migraine: A systematic review and meta-analysis. Cephalalgia. 2020 09; 40(10):1095-1103. PMID: 32349538.
    Citations: 3     Fields:    Translation:Humans
  23. Iljazi A, Chua A, Rich-Fiondella R, Veronesi M, Melo-Carrillo A, Ashina S, Burstein R, Grosberg B. Unrecognized challenges of treating status migrainosus: An observational study. Cephalalgia. 2020 07; 40(8):818-827. PMID: 32162976.
    Citations: 3     Fields:    Translation:Humans
  24. Burke MJ, Joutsa J, Cohen AL, Soussand L, Cooke D, Burstein R, Fox MD. Mapping migraine to a common brain network. Brain. 2020 02 01; 143(2):541-553. PMID: 31919494; PMCID: PMC7009560.
    Citations: 11     Fields:    Translation:Humans
  25. Noseda R, Schain AJ, Melo-Carrillo A, Tien J, Stratton J, Mai F, Strassman AM, Burstein R. Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier. Cephalalgia. 2020 03; 40(3):229-240. PMID: 31856583.
    Citations: 15     Fields:    Translation:Animals
  26. Bertisch SM, Li W, Buettner C, Mostofsky E, Rueschman M, Kaplan ER, Fung J, Huntington S, Murphy T, Stead C, Burstein R, Redline S, Mittleman MA. Nightly sleep duration, fragmentation, and quality and daily risk of migraine. Neurology. 2020 02 04; 94(5):e489-e496. PMID: 31843807; PMCID: PMC7080287.
    Citations: 13     Fields:    Translation:Humans
  27. Holmes SA, Barakat N, Bhasin M, Lopez NI, Lebel A, Zurakowski D, Thomas B, Bhasin S, Silva KE, Borra R, Burstein R, Simons LE, Borsook D. Biological and behavioral markers of pain following nerve injury in humans. Neurobiol Pain. 2020 Jan-Jul; 7:100038. PMID: 31890990; PMCID: PMC6926375.
    Citations: 5     
  28. Burstein R. Reply to Spitschan. Pain. 2019 10; 160(10):2409-2410. PMID: 31568101; PMCID: PMC7250251.
    Citations:    Fields:    Translation:Humans
  29. Mancini AJ, Glassman RD, Chang YM, Burstein R, Ashina S. Headache in Petrous Apicitis: A Case Report of Chronic Migraine-like Headache Due to Peripheral Pathology. Headache. 2019 11; 59(10):1821-1826. PMID: 31535370.
    Citations: 2     Fields:    Translation:Humans
  30. Bishop J, Becerra L, Barmettler G, Chang PC, Kainz V, Burstein R, Borsook D. Modulation of brain networks by sumatriptan-naproxen in the inflammatory soup migraine model. Pain. 2019 09; 160(9):2161-2171. PMID: 31033778; PMCID: PMC7193782.
    Citations: 2     Fields:    Translation:Animals
  31. Melo-Carrillo A, Strassman AM, Schain AJ, Noseda R, Ashina S, Adams A, Brin MF, Burstein R. Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats. Cephalalgia. 2019 10; 39(11):1358-1365. PMID: 31475573.
    Citations: 8     Fields:    Translation:AnimalsCells
  32. May A, Burstein R. Hypothalamic regulation of headache and migraine. Cephalalgia. 2019 11; 39(13):1710-1719. PMID: 31466456; PMCID: PMC7164212.
    Citations: 19     Fields:    Translation:Humans
  33. Blake P, Burstein R. Emerging evidence of occipital nerve compression in unremitting head and neck pain. J Headache Pain. 2019 Jul 02; 20(1):76. PMID: 31266456.
    Citations: 5     Fields:    Translation:Humans
  34. Ashina M, Hansen JM, Do TP, Melo-Carrillo A, Burstein R, Moskowitz MA. Migraine and the trigeminovascular system-40 years and counting. Lancet Neurol. 2019 08; 18(8):795-804. PMID: 31160203.
    Citations: 49     Fields:    Translation:Humans
  35. Schain AJ, Melo-Carrillo A, Stratton J, Strassman AM, Burstein R. CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura. J Neurosci. 2019 07 24; 39(30):6001-6011. PMID: 31127003; PMCID: PMC6650995.
    Citations: 10     Fields:    Translation:Animals
  36. Yarnitsky D, Dodick DW, Grosberg BM, Burstein R, Ironi A, Harris D, Lin T, Silberstein SD. Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. Headache. 2019 09; 59(8):1240-1252. PMID: 31074005.
    Citations: 23     Fields:    Translation:Humans
  37. Colon E, Ludwick A, Wilcox SL, Youssef AM, Danehy A, Fair DA, Lebel AA, Burstein R, Becerra L, Borsook D. Migraine in the Young Brain: Adolescents vs. Young Adults. Front Hum Neurosci. 2019; 13:87. PMID: 30967767; PMCID: PMC6438928.
    Citations: 5     
  38. Bernstein CA, Nir RR, Noseda R, Fulton AB, Huntington S, Lee AJ, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2019 Mar; 160(3):569-578. PMID: 30376534; PMCID: PMC6460478.
    Citations: 8     Fields:    Translation:Humans
  39. Burstein R, Noseda R, Fulton AB. Neurobiology of Photophobia. J Neuroophthalmol. 2019 03; 39(1):94-102. PMID: 30762717; PMCID: PMC6383812.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  40. Noseda R, Melo-Carrillo A, Nir RR, Strassman AM, Burstein R. Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache. J Neurosci. 2019 03 06; 39(10):1867-1880. PMID: 30622169; PMCID: PMC6407291.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034. PMID: 29905657; PMCID: PMC6347023.
    Citations: 5     Fields:    Translation:Humans
  42. Blake P, Nir RR, Perry CJ, Burstein R. Tracking patients with chronic occipital headache after occipital nerve decompression surgery: A case series. Cephalalgia. 2019 04; 39(4):556-563. PMID: 30217120.
    Citations: 4     Fields:    Translation:Humans
  43. Platzbecker K, Zhang MB, Kurth T, Rudolph MI, Eikermann-Haerter K, Burstein R, Eikermann M, Houle T. The association between migraine and hospital readmission due to pain after surgery: A hospital registry study. Cephalalgia. 2019 02; 39(2):286-295. PMID: 29984600; PMCID: PMC7192134.
    Citations: 3     Fields:    Translation:Humans
  44. Noseda R, Copenhagen D, Burstein R. Current understanding of photophobia, visual networks and headaches. Cephalalgia. 2019 11; 39(13):1623-1634. PMID: 29940781; PMCID: PMC6461529.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  45. Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 03; 83(3):508-521. PMID: 29394508; PMCID: PMC5965700.
    Citations: 25     Fields:    Translation:AnimalsCells
  46. Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. PMID: 29487563; PMCID: PMC5816750.
    Citations: 17     
  47. Melo-Carrillo A, Strassman AM, Nir RR, Schain AJ, Noseda R, Stratton J, Burstein R. Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017 11 01; 37(44):10587-10596. PMID: 28972120; PMCID: PMC5666582.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  48. Noseda R, Lee AJ, Nir RR, Bernstein CA, Kainz VM, Bertisch SM, Buettner C, Borsook D, Burstein R. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692. PMID: 28652355; PMCID: PMC5514773.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  49. Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R. Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017 07 26; 37(30):7149-7163. PMID: 28642283; PMCID: PMC5546397.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  50. Lipton RB, Munjal S, Buse DC, Bennett A, Fanning KM, Burstein R, Reed ML. Allodynia Is Associated With Initial and Sustained Response to Acute Migraine Treatment: Results from the American Migraine Prevalence and Prevention Study. Headache. 2017 Jul; 57(7):1026-1040. PMID: 28603893.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  51. Burstein R, Blake P, Schain A, Perry C. Extracranial origin of headache. Curr Opin Neurol. 2017 06; 30(3):263-271. PMID: 28248698; PMCID: PMC6051727.
    Citations: 13     Fields:    Translation:Humans
  52. Youssef AM, Ludwick A, Wilcox SL, Lebel A, Peng K, Colon E, Danehy A, Burstein R, Becerra L, Borsook D. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. PMID: 28560777.
    Citations: 11     Fields:    Translation:Humans
  53. Noseda R, Borsook D, Burstein R. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111. PMID: 28485844.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  54. Buettner C, Melo-Carrillo A, Burstein R. Terminating Migraine-Associated Allodynia Using Oral Suspension Diclofenac: A Prospective Non-Randomized Drug Trial. Headache. 2017 03; 57(3):478-486. PMID: 28225188; PMCID: PMC7181471.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  55. Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci. 2017 03 15; 37(11):2904-2915. PMID: 28193695; PMCID: PMC5354333.
    Citations: 65     Fields:    Translation:AnimalsCells
  56. Becerra L, Bishop J, Barmettler G, Kainz V, Burstein R, Borsook D. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 04 01; 1660:36-46. PMID: 28167076; PMCID: PMC5731648.
    Citations: 16     Fields:    Translation:Animals
  57. Hodkinson DJ, Veggeberg R, Kucyi A, van Dijk KR, Wilcox SL, Scrivani SJ, Burstein R, Becerra L, Borsook D. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28101529.
    Citations: 23     Fields:    Translation:Humans
  58. Burstein R. Reply: Pupil area and photopigment spectral sensitivity are relevant to study of migraine photophobia. Brain. 2017 01; 140(1):e3. PMID: 28031225; PMCID: PMC5226061.
    Citations: 1     Fields:    Translation:HumansCells
  59. Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. PMID: 27766076; PMCID: PMC5052273.
    Citations: 20     
  60. Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36. PMID: 27466345; PMCID: PMC4961783.
    Citations: 29     Fields:    Translation:Humans
  61. Wilcox SL, Veggeberg R, Lemme J, Hodkinson DJ, Scrivani S, Burstein R, Becerra L, Borsook D. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. PMID: 27507939; PMCID: PMC4960233.
    Citations: 28     
  62. Noseda R, Bernstein CA, Nir RR, Lee AJ, Fulton AB, Bertisch SM, Hovaguimian A, Cestari DM, Saavedra-Walker R, Borsook D, Doran BL, Buettner C, Burstein R. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86. PMID: 27190022; PMCID: PMC4939697.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  63. Perry CJ, Blake P, Buettner C, Papavassiliou E, Schain AJ, Bhasin MK, Burstein R. Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache. Ann Neurol. 2016 06; 79(6):1000-13. PMID: 27091721; PMCID: PMC4884147.
    Citations: 21     Fields:    Translation:Humans
  64. Becerra L, Veggeberg R, Prescot A, Jensen JE, Renshaw P, Scrivani S, Spierings ELH, Burstein R, Borsook D. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-594. PMID: 27158591.
    Citations: 13     Fields:    Translation:Humans
  65. Zhang X, Strassman AM, Novack V, Brin MF, Burstein R. Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? Cephalalgia. 2016 Aug; 36(9):875-86. PMID: 26984967.
    Citations: 29     Fields:    Translation:AnimalsCells
  66. Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA, Burstein R. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015 Dec; 78(6):970-81. PMID: 26418341; PMCID: PMC4715556.
    Citations: 29     Fields:    Translation:Humans
  67. Faria V, Erpelding N, Lebel A, Johnson A, Wolff R, Fair D, Burstein R, Becerra L, Borsook D. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-2221. PMID: 26172552.
    Citations: 20     Fields:    Translation:Humans
  68. Bigal ME, Dodick DW, Rapoport AM, Silberstein SD, Ma Y, Yang R, Loupe PS, Burstein R, Newman LC, Lipton RB. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1081-90. PMID: 26432182.
    Citations: 95     Fields:    Translation:HumansCTClinical Trials
  69. Bigal ME, Edvinsson L, Rapoport AM, Lipton RB, Spierings EL, Diener HC, Burstein R, Loupe PS, Ma Y, Yang R, Silberstein SD. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1091-100. PMID: 26432181.
    Citations: 99     Fields:    Translation:HumansCTClinical Trials
  70. Hodkinson DJ, Veggeberg R, Wilcox SL, Scrivani S, Burstein R, Becerra L, Borsook D. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. PMID: 26372461.
    Citations: 22     Fields:    Translation:Humans
  71. Borsook D, Veggeberg R, Erpelding N, Borra R, Linnman C, Burstein R, Becerra L. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 12; 22(6):632-652. PMID: 26290446.
    Citations: 48     Fields:    Translation:HumansAnimals
  72. Maleki N, Barmettler G, Moulton EA, Scrivani S, Veggeberg R, Spierings ELH, Burstein R, Becerra L, Borsook D. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-1239. PMID: 25775358; PMCID: PMC4474740.
    Citations: 17     Fields:    Translation:Humans
  73. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29. PMID: 25926442; PMCID: PMC4412887.
    Citations: 168     Fields:    Translation:HumansCells
  74. Buettner C, Burstein R. Association of statin use and risk for severe headache or migraine by serum vitamin D status: a cross-sectional population-based study. Cephalalgia. 2015 Aug; 35(9):757-66. PMID: 25424706.
    Citations: 15     Fields:    Translation:Humans
  75. Barmettler G, Brawn J, Maleki N, Scrivani S, Burstein R, Becerra L, Borsook D. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. PMID: 25143550.
    Citations: 5     Fields:    Translation:Humans
  76. Noseda R, Kainz V, Borsook D, Burstein R. Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929. PMID: 25090640.
    Citations: 29     Fields:    Translation:AnimalsCells
  77. Files JA, Schwedt TJ, Mayer AP, David PS, Vargas BB, Chang YH, Hunt M, Patel S, Ko MG, Tozer BS, Burstein R, Dodick DW. Imploding and exploding migraine headaches: comparison of methods to diagnose pain directionality. Headache. 2014 Jun; 54(6):1010-8. PMID: 24527766.
    Citations: 1     Fields:    Translation:Humans
  78. Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. PMID: 24743801.
    Citations: 40     Fields:    Translation:Humans
  79. Burstein R, Zhang X, Levy D, Aoki KR, Brin MF. Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69. PMID: 24694964.
    Citations: 71     Fields:    Translation:AnimalsCells
  80. Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant PE, Buettner C, Becerra L, Burstein R. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. PMID: 24662368.
    Citations: 31     Fields:    Translation:HumansAnimals
  81. Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, Burstein R. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med. 2014 Jan 08; 6(218):218ra5. PMID: 24401940.
    Citations: 114     Fields:    Translation:Humans
  82. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013 Dec; 154 Suppl 1. PMID: 24347803.
    Citations: 45     Fields:    
  83. Borsook D, Aasted CM, Burstein R, Becerra L. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. PMID: 24047609.
    Citations: 8     Fields:    Translation:Humans
  84. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013 Dec; 154 Suppl 1:S44-53. PMID: 23891892.
    Citations: 194     Fields:    Translation:HumansAnimals
  85. Kagan R, Kainz V, Burstein R, Noseda R. Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia. Neuroscience. 2013 Sep 17; 248:359-68. PMID: 23806720.
    Citations: 27     Fields:    Translation:AnimalsCells
  86. Strassman AM, Burstein R. A new animal model of headache: Ongoing pain vs stimulus-evoked hypersensitivity. Cephalalgia. 2013 Oct; 33(13):1073-4. PMID: 23766356.
    Citations: 2     Fields:    Translation:Animals
  87. Zhang X, Jakubowski M, Buettner C, Kainz V, Gold M, Burstein R. Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression. Epilepsy Behav. 2013 Aug; 28(2):243-8. PMID: 23562239.
    Citations: 7     Fields:    Translation:AnimalsCells
  88. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. PMID: 22843414; PMCID: PMC3407427.
    Citations: 80     Fields:    Translation:Humans
  89. Borsook D, Burstein R. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12. PMID: 22798640.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  90. Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. PMID: 22760159.
    Citations: 59     Fields:    Translation:Humans
  91. Bernstein C, Burstein R. Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012 Jun; 8(2):89-99. PMID: 22787491.
    Citations: 100     
  92. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. PMID: 22623760.
    Citations: 75     Fields:    Translation:Humans
  93. Burstein R, Strassman A, Moskowitz M. Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia. 2012 Apr; 32(6):509-11. PMID: 22345633.
    Citations: 6     Fields:    Translation:AnimalsCells
  94. Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72. PMID: 22144718.
    Citations: 37     Fields:    Translation:AnimalsCells
  95. Levy D, Moskowitz MA, Noseda R, Burstein R. Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2. PMID: 21996564.
    Citations: 4     Fields:    Translation:Animals
  96. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552.
    Citations: 41     Fields:    Translation:AnimalsCells
  97. Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17. PMID: 21976505.
    Citations: 66     Fields:    Translation:AnimalsCells
  98. Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. PMID: 21936901.
    Citations: 57     Fields:    Translation:Humans
  99. Noseda R, Burstein R. Advances in understanding the mechanisms of migraine-type photophobia. Curr Opin Neurol. 2011 Jun; 24(3):197-202. PMID: 21467933.
    Citations: 41     Fields:    Translation:HumansAnimals
  100. Levy D, Burstein R. The vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1. PMID: 21520229.
    Citations: 11     Fields:    Translation:HumansCells
  101. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65. PMID: 21416489.
    Citations: 132     Fields:    Translation:AnimalsCells
  102. Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. PMID: 21337474.
    Citations: 34     Fields:    Translation:Humans
  103. Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res. 2011; 21(6):305-14. PMID: 22348935; PMCID: PMC3690498.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  104. Burstein R, Kim CC, Dover JS, Arndt KA. Botulinum toxin type a headache treatment and entrapment of the supratrochlear nerve-reply. Arch Dermatol. 2010 Nov 15; 146(11):1311. PMID: 22637178.
    Citations:    
  105. Zhang XC, Kainz V, Burstein R, Levy D. Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-149. PMID: 21036476.
    Citations: 57     Fields:    Translation:AnimalsCells
  106. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. PMID: 20582997.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  107. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14. PMID: 20592202.
    Citations: 138     Fields:    Translation:AnimalsCells
  108. Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. PMID: 20562317.
    Citations: 93     Fields:    Translation:Humans
  109. Simopoulos T, Bajwa Z, Lantz G, Lee S, Burstein R. Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine. Headache. 2010 Jun; 50(6):1064-9. PMID: 20618819.
    Citations: 8     Fields:    Translation:Humans
  110. Kim CC, Bogart MM, Wee SA, Burstein R, Arndt KA, Dover JS. Predicting migraine responsiveness to botulinum toxin type A injections. Arch Dermatol. 2010 Feb; 146(2):159-63. PMID: 20157026.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  111. Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb; 13(2):239-45. PMID: 20062053.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  112. Burstein R, Jakubowski M. Managing migraine associated with sensitization. Handb Clin Neurol. 2010; 97:207-15. PMID: 20816422.
    Citations: 7     Fields:    Translation:HumansCells
  113. Kosaras B, Jakubowski M, Kainz V, Burstein R. Sensory innervation of the calvarial bones of the mouse. J Comp Neurol. 2009 Jul 20; 515(3):331-48. PMID: 19425099.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  114. Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol. 2009 Jul; 8(7):679-90. PMID: 19539239.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  115. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. PMID: 19566960.
    Citations: 32     Fields:    Translation:Humans
  116. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    Citations: 28     Fields:    Translation:HumansCells
  117. Burstein R, Jakubowski M. Neural substrate of depression during migraine. Neurol Sci. 2009 May; 30 Suppl 1:S27-31. PMID: 19415422.
    Citations: 9     Fields:    Translation:Humans
  118. Aurora SK, Barrodale PM, McDonald SA, Jakubowski M, Burstein R. Revisiting the efficacy of sumatriptan therapy during the aura phase of migraine. Headache. 2009 Jul; 49(7):1001-4. PMID: 19438735.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  119. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941.
    Citations: 12     Fields:    Translation:AnimalsCells
  120. Burstein R. Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia? Headache. 2009 Mar; 49(3):364-5. PMID: 19267784.
    Citations: 1     Fields:    Translation:Humans
  121. Burstein R, Dodick D, Silberstein S. Migraine prophylaxis with botulinum toxin A is associated with perception of headache. Toxicon. 2009 Oct; 54(5):624-7. PMID: 19344670.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  122. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. PMID: 19030105.
    Citations: 78     Fields:    Translation:HumansCells
  123. Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22. PMID: 18333963.
    Citations: 19     Fields:    Translation:AnimalsCells
  124. Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. Cutaneous allodynia in the migraine population. Ann Neurol. 2008 Feb; 63(2):148-58. PMID: 18059010.
    Citations: 169     Fields:    Translation:HumansCells
  125. Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83. PMID: 17651900.
    Citations: 22     Fields:    Translation:AnimalsCells
  126. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    Citations: 56     Fields:    Translation:AnimalsCells
  127. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586.
    Citations: 131     Fields:    Translation:AnimalsCells
  128. Jakubowski M, McAllister PJ, Bajwa ZH, Ward TN, Smith P, Burstein R. Exploding vs. imploding headache in migraine prophylaxis with Botulinum Toxin A. Pain. 2006 Dec 05; 125(3):286-295. PMID: 17069972; PMCID: PMC1831831.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  129. Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. PMID: 16927962.
    Citations: 9     Fields:    Translation:Humans
  130. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    Citations: 23     Fields:    Translation:HumansCells
  131. Burstein R, Jakubowski M. Unitary hypothesis for multiple triggers of the pain and strain of migraine. J Comp Neurol. 2005 Dec 05; 493(1):9-14. PMID: 16258903.
    Citations: 54     Fields:    Translation:HumansCells
  132. Jakubowski M, Silberstein S, Ashkenazi A, Burstein R. Can allodynic migraine patients be identified interictally using a questionnaire? Neurology. 2005 Nov 08; 65(9):1419-22. PMID: 16275830.
    Citations: 41     Fields:    Translation:HumansCells
  133. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    Citations: 76     Fields:    Translation:AnimalsCells
  134. Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61. PMID: 15985101.
    Citations: 54     Fields:    Translation:HumansAnimalsCTClinical Trials
  135. Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60. PMID: 16141951.
    Citations: 30     Fields:    Translation:HumansCells
  136. Burstein R, Jakubowski M. Implications of multimechanism therapy: when to treat? Neurology. 2005 May 24; 64(10 Suppl 2):S16-20. PMID: 15911782.
    Citations: 5     Fields:    Translation:HumansAnimals
  137. Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8. PMID: 15836966.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  138. Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. PMID: 15362156.
    Citations: 30     Fields:    Translation:Humans
  139. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9. PMID: 15016917; PMCID: PMC384731.
    Citations: 73     Fields:    Translation:AnimalsCells
  140. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004 Jan; 55(1):27-36. PMID: 14705109.
    Citations: 95     Fields:    Translation:AnimalsCells
  141. Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004 Jan; 55(1):19-26. PMID: 14705108.
    Citations: 142     Fields:    Translation:Humans
  142. Yarnitsky D, Goor-Aryeh I, Bajwa ZH, Ransil BI, Cutrer FM, Sottile A, Burstein R. 2003 Wolff Award: Possible parasympathetic contributions to peripheral and central sensitization during migraine. Headache. 2003 Jul-Aug; 43(7):704-14. PMID: 12890124.
    Citations: 38     Fields:    Translation:HumansCells
  143. Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9930-5. PMID: 11504950; PMCID: PMC55555.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  144. Burstein R. Deconstructing migraine headache into peripheral and central sensitization. Pain. 2001 Jan; 89(2-3):107-10. PMID: 11166465.
    Citations: 101     Fields:    Translation:Humans
  145. Malick A, Strassman RM, Burstein R. Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat. J Neurophysiol. 2000 Oct; 84(4):2078-112. PMID: 11024099.
    Citations: 58     Fields:    Translation:AnimalsCells
  146. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000 Aug; 123 ( Pt 8):1703-9. PMID: 10908199.
    Citations: 173     Fields:    Translation:Humans
  147. Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000 May; 47(5):614-24. PMID: 10805332.
    Citations: 269     Fields:    Translation:HumansCells
  148. Malick A, Burstein R. Peripheral and central sensitization during migraine. Funct Neurol. 2000; 15 Suppl 3:28-35. PMID: 11200798.
    Citations: 27     Fields:    Translation:Animals
  149. Yamamura H, Malick A, Chamberlin NL, Burstein R. Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. J Neurophysiol. 1999 Feb; 81(2):479-93. PMID: 10036252.
    Citations: 23     Fields:    Translation:AnimalsCells
  150. Malick A, Burstein R. Cells of origin of the trigeminohypothalamic tract in the rat. J Comp Neurol. 1998 Oct 12; 400(1):125-44. PMID: 9762871.
    Citations: 36     Fields:    Translation:AnimalsCells
  151. Burstein R, Yamamura H, Malick A, Strassman AM. Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons. J Neurophysiol. 1998 Feb; 79(2):964-82. PMID: 9463456.
    Citations: 182     Fields:    Translation:AnimalsCells
  152. Strassman AM, Raymond SA, Burstein R. Sensitization of meningeal sensory neurons and the origin of headaches. Nature. 1996 Dec 12; 384(6609):560-4. PMID: 8955268.
    Citations: 205     Fields:    Translation:AnimalsCells
  153. Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. PMID: 8889944.
    Citations: 4     Fields:    Translation:AnimalsCells
  154. Burstein R. Somatosensory and visceral input to the hypothalamus and limbic system. Prog Brain Res. 1996; 107:257-67. PMID: 8782524.
    Citations: 1     Fields:    Translation:Animals
  155. Fields HL, Malick A, Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol. 1995 Oct; 74(4):1742-59. PMID: 8989409.
    Citations: 61     Fields:    Translation:AnimalsCells
  156. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. PMID: 8152426.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  157. Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. PMID: 8294956.
    Citations: 17     Fields:    Translation:AnimalsCells
  158. Burstein R, Potrebic S. Retrograde labeling of neurons in the spinal cord that project directly to the amygdala or the orbital cortex in the rat. J Comp Neurol. 1993 Sep 22; 335(4):469-85. PMID: 8227531.
    Citations: 19     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.