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Rami Burstein, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS094198 (BURSTEIN, RAMI) Jul 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Cortical Mechanisms of Headache: Beyond CSD
    Role: Principal Investigator
  2. R37NS079678 (BURSTEIN, RAMI) Jul 1, 2012 - Jun 30, 2019
    NIH/NINDS
    Photophobia during migraine: sensory, autonomic and emotional responses to light
    Role: Principal Investigator
  3. R01NS069847 (BURSTEIN, RAMI) Feb 1, 2010 - Jan 31, 2015
    NIH/NINDS
    Migraine pathophysiology: neural basis of photophobia
    Role: Principal Investigator
  4. R01NS051484 (BURSTEIN, RAMI) Jun 1, 2005 - Mar 31, 2011
    NIH/NINDS
    Migraine Pathophysiology:Thalamus and Extended Allodynia
    Role: Principal Investigator
  5. R01DE013347 (BURSTEIN, RAMI) Apr 1, 2000 - Mar 31, 2005
    NIH/NIDCR
    NEUROBIOLOGY OF ANOREXIA INDUCED BY MIGRAINE PAIN
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R. Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Jun 12. PMID: 29905657.
    View in: PubMed
  2. Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 Mar; 83(3):508-521. PMID: 29394508.
    View in: PubMed
  3. Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine. Front Neurol. 2018; 9:61. PMID: 29487563.
    View in: PubMed
  4. Noseda R, Copenhagen D, Burstein R. Current understanding of photophobia, visual networks and headaches. Cephalalgia. 2018 Jan 01; 333102418784750. PMID: 29940781.
    View in: PubMed
  5. Platzbecker K, Zhang MB, Kurth T, Rudolph MI, Eikermann-Haerter K, Burstein R, Eikermann M, Houle T. The association between migraine and hospital readmission due to pain after surgery: A hospital registry study. Cephalalgia. 2018 Jan 01; 333102418786457. PMID: 29984600.
    View in: PubMed
  6. Melo-Carrillo A, Strassman AM, Nir RR, Schain AJ, Noseda R, Stratton J, Burstein R. Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017 Nov 01; 37(44):10587-10596. PMID: 28972120.
    View in: PubMed
  7. Noseda R, Lee AJ, Nir RR, Bernstein CA, Kainz VM, Bertisch SM, Buettner C, Borsook D, Burstein R. Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692. PMID: 28652355.
    View in: PubMed
  8. Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R. Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017 07 26; 37(30):7149-7163. PMID: 28642283.
    View in: PubMed
  9. Lipton RB, Munjal S, Buse DC, Bennett A, Fanning KM, Burstein R, Reed ML. Allodynia Is Associated With Initial and Sustained Response to Acute Migraine Treatment: Results from the American Migraine Prevalence and Prevention Study. Headache. 2017 Jul; 57(7):1026-1040. PMID: 28603893.
    View in: PubMed
  10. Burstein R, Blake P, Schain A, Perry C. Extracranial origin of headache. Curr Opin Neurol. 2017 06; 30(3):263-271. PMID: 28248698.
    View in: PubMed
  11. Youssef AM, Ludwick A, Wilcox SL, Lebel A, Peng K, Colon E, Danehy A, Burstein R, Becerra L, Borsook D. In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp. 2017 08; 38(8):4078-4087. PMID: 28560777.
    View in: PubMed
  12. Noseda R, Borsook D, Burstein R. Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111. PMID: 28485844.
    View in: PubMed
  13. Buettner C, Melo-Carrillo A, Burstein R. Terminating Migraine-Associated Allodynia Using Oral Suspension Diclofenac: A Prospective Non-Randomized Drug Trial. Headache. 2017 03; 57(3):478-486. PMID: 28225188.
    View in: PubMed
  14. Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci. 2017 03 15; 37(11):2904-2915. PMID: 28193695.
    View in: PubMed
  15. Becerra L, Bishop J, Barmettler G, Kainz V, Burstein R, Borsook D. Brain network alterations in the inflammatory soup animal model of migraine. Brain Res. 2017 04 01; 1660:36-46. PMID: 28167076.
    View in: PubMed
  16. Hodkinson DJ, Veggeberg R, Kucyi A, van Dijk KR, Wilcox SL, Scrivani SJ, Burstein R, Becerra L, Borsook D. Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28101529.
    View in: PubMed
  17. Burstein R. Reply: Pupil area and photopigment spectral sensitivity are relevant to study of migraine photophobia. Brain. 2017 01; 140(1):e3. PMID: 28031225.
    View in: PubMed
  18. Hubbard CS, Becerra L, Smith JH, DeLange JM, Smith RM, Black DF, Welker KM, Burstein R, Cutrer FM, Borsook D. Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal. Front Hum Neurosci. 2016; 10:497. PMID: 27766076.
    View in: PubMed
  19. Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L. Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36. PMID: 27466345; PMCID: PMC4961783 [Available on 01/27/17].
  20. Wilcox SL, Veggeberg R, Lemme J, Hodkinson DJ, Scrivani S, Burstein R, Becerra L, Borsook D. Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine. Front Hum Neurosci. 2016; 10:366. PMID: 27507939; PMCID: PMC4960233.
  21. Noseda R, Bernstein CA, Nir RR, Lee AJ, Fulton AB, Bertisch SM, Hovaguimian A, Cestari DM, Saavedra-Walker R, Borsook D, Doran BL, Buettner C, Burstein R. Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86. PMID: 27190022; PMCID: PMC4939697 [Available on 07/01/17].
  22. Perry CJ, Blake P, Buettner C, Papavassiliou E, Schain AJ, Bhasin MK, Burstein R. Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache. Ann Neurol. 2016 06; 79(6):1000-13. PMID: 27091721.
    View in: PubMed
  23. Becerra L, Veggeberg R, Prescot A, Jensen JE, Renshaw P, Scrivani S, Spierings EL, Burstein R, Borsook D. A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 2016; 11:588-94. PMID: 27158591; PMCID: PMC4846856.
  24. Zhang X, Strassman AM, Novack V, Brin MF, Burstein R. Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? Cephalalgia. 2016 Aug; 36(9):875-86. PMID: 26984967; PMCID: PMC4959034.
  25. Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA, Burstein R. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015 Dec; 78(6):970-81. PMID: 26418341; PMCID: PMC4715556 [Available on 12/01/16].
  26. Faria V, Erpelding N, Lebel A, Johnson A, Wolff R, Fair D, Burstein R, Becerra L, Borsook D. The migraine brain in transition: girls vs boys. Pain. 2015 Nov; 156(11):2212-21. PMID: 26172552.
    View in: PubMed
  27. Bigal ME, Edvinsson L, Rapoport AM, Lipton RB, Spierings EL, Diener HC, Burstein R, Loupe PS, Ma Y, Yang R, Silberstein SD. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1091-100. PMID: 26432181.
    View in: PubMed
  28. Bigal ME, Dodick DW, Rapoport AM, Silberstein SD, Ma Y, Yang R, Loupe PS, Burstein R, Newman LC, Lipton RB. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol. 2015 Nov; 14(11):1081-90. PMID: 26432182.
    View in: PubMed
  29. Hodkinson DJ, Veggeberg R, Wilcox SL, Scrivani S, Burstein R, Becerra L, Borsook D. Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine. PLoS One. 2015; 10(9):e0137971. PMID: 26372461; PMCID: PMC4570777.
  30. Borsook D, Veggeberg R, Erpelding N, Borra R, Linnman C, Burstein R, Becerra L. The Insula: A "Hub of Activity" in Migraine. Neuroscientist. 2016 12; 22(6):632-652. PMID: 26290446.
    View in: PubMed
  31. Maleki N, Barmettler G, Moulton EA, Scrivani S, Veggeberg R, Spierings EL, Burstein R, Becerra L, Borsook D. Female migraineurs show lack of insular thinning with age. Pain. 2015 Jul; 156(7):1232-9. PMID: 25775358; PMCID: PMC4474740.
  32. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29. PMID: 25926442; PMCID: PMC4412887.
  33. Buettner C, Burstein R. Association of statin use and risk for severe headache or migraine by serum vitamin D status: a cross-sectional population-based study. Cephalalgia. 2015 Aug; 35(9):757-66. PMID: 25424706.
    View in: PubMed
  34. Barmettler G, Brawn J, Maleki N, Scrivani S, Burstein R, Becerra L, Borsook D. A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. Cephalalgia. 2015 Apr; 35(5):417-25. PMID: 25143550.
    View in: PubMed
  35. Noseda R, Kainz V, Borsook D, Burstein R. Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929. PMID: 25090640; PMCID: PMC4121288.
  36. Files JA, Schwedt TJ, Mayer AP, David PS, Vargas BB, Chang YH, Hunt M, Patel S, Ko MG, Tozer BS, Burstein R, Dodick DW. Imploding and exploding migraine headaches: comparison of methods to diagnose pain directionality. Headache. 2014 Jun; 54(6):1010-8. PMID: 24527766; PMCID: PMC4452952.
  37. Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One. 2014; 9(4):e95508. PMID: 24743801; PMCID: PMC3990690.
  38. Burstein R, Zhang X, Levy D, Aoki KR, Brin MF. Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69. PMID: 24694964; PMCID: PMC4167963.
  39. Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant PE, Buettner C, Becerra L, Burstein R. Sex and the migraine brain. Neurobiol Dis. 2014 Aug; 68:200-14. PMID: 24662368; PMCID: PMC4171725.
  40. Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, Burstein R. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med. 2014 Jan 08; 6(218):218ra5. PMID: 24401940; PMCID: PMC4005597.
  41. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013 Dec; 154 Suppl 1. PMID: 24347803.
    View in: PubMed
  42. Borsook D, Aasted CM, Burstein R, Becerra L. Migraine Mistakes: Error Awareness. Neuroscientist. 2014 Jun; 20(3):291-304. PMID: 24047609.
    View in: PubMed
  43. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013 Dec; 154 Suppl 1:S44-53. PMID: 23891892.
    View in: PubMed
  44. Kagan R, Kainz V, Burstein R, Noseda R. Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia. Neuroscience. 2013 Sep 17; 248:359-68. PMID: 23806720; PMCID: PMC3858508.
  45. Strassman AM, Burstein R. A new animal model of headache: Ongoing pain vs stimulus-evoked hypersensitivity. Cephalalgia. 2013 Oct; 33(13):1073-4. PMID: 23766356.
    View in: PubMed
  46. Zhang X, Jakubowski M, Buettner C, Kainz V, Gold M, Burstein R. Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression. Epilepsy Behav. 2013 Aug; 28(2):243-8. PMID: 23562239; PMCID: PMC3700644.
  47. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59. PMID: 22843414; PMCID: PMC3407427.
  48. Borsook D, Burstein R. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12. PMID: 22798640; PMCID: PMC3711518.
  49. Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013 Jul; 218(4):903-12. PMID: 22760159; PMCID: PMC3711530.
  50. Bernstein C, Burstein R. Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012 Jun; 8(2):89-99. PMID: 22787491; PMCID: PMC3391624.
  51. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20. PMID: 22623760; PMCID: PMC3846436.
  52. Burstein R, Strassman A, Moskowitz M. Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia. 2012 Apr; 32(6):509-11. PMID: 22345633; PMCID: PMC3717575.
  53. Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72. PMID: 22144718; PMCID: PMC3674888.
  54. Levy D, Moskowitz MA, Noseda R, Burstein R. Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2. PMID: 21996564; PMCID: PMC3698973.
  55. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552; PMCID: PMC3264697.
  56. Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17. PMID: 21976505; PMCID: PMC3501387.
  57. Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011 Sep 21; 7:71. PMID: 21936901; PMCID: PMC3192678.
  58. Noseda R, Burstein R. Advances in understanding the mechanisms of migraine-type photophobia. Curr Opin Neurol. 2011 Jun; 24(3):197-202. PMID: 21467933; PMCID: PMC4502959.
  59. Levy D, Burstein R. The vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1. PMID: 21520229.
    View in: PubMed
  60. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65. PMID: 21416489; PMCID: PMC3174689.
  61. Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88. PMID: 21337474; PMCID: PMC3711521.
  62. Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res. 2011; 21(6):305-14. PMID: 22348935; PMCID: PMC3690498.
  63. Burstein R, Kim CC, Dover JS, Arndt KA. Botulinum toxin type a headache treatment and entrapment of the supratrochlear nerve-reply. Arch Dermatol. 2010 Nov 15; 146(11):1311. PMID: 22637178.
    View in: PubMed
  64. Zhang XC, Kainz V, Burstein R, Levy D. Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-9. PMID: 21036476; PMCID: PMC3391748.
  65. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91. PMID: 20582997; PMCID: PMC2930514.
  66. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14. PMID: 20592202; PMCID: PMC2907647.
  67. Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48. PMID: 20562317; PMCID: PMC3020583.
  68. Simopoulos T, Bajwa Z, Lantz G, Lee S, Burstein R. Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine. Headache. 2010 Jun; 50(6):1064-9. PMID: 20618819.
    View in: PubMed
  69. Kim CC, Bogart MM, Wee SA, Burstein R, Arndt KA, Dover JS. Predicting migraine responsiveness to botulinum toxin type A injections. Arch Dermatol. 2010 Feb; 146(2):159-63. PMID: 20157026.
    View in: PubMed
  70. Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb; 13(2):239-45. PMID: 20062053; PMCID: PMC2818758.
  71. Burstein R, Jakubowski M. Managing migraine associated with sensitization. Handb Clin Neurol. 2010; 97:207-15. PMID: 20816422.
    View in: PubMed
  72. Kosaras B, Jakubowski M, Kainz V, Burstein R. Sensory innervation of the calvarial bones of the mouse. J Comp Neurol. 2009 Jul 20; 515(3):331-48. PMID: 19425099; PMCID: PMC2710390.
  73. Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol. 2009 Jul; 8(7):679-90. PMID: 19539239.
    View in: PubMed
  74. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009 Jun 30; 5:34. PMID: 19566960; PMCID: PMC2714306.
  75. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    View in: PubMed
  76. Burstein R, Jakubowski M. Neural substrate of depression during migraine. Neurol Sci. 2009 May; 30 Suppl 1:S27-31. PMID: 19415422.
    View in: PubMed
  77. Aurora SK, Barrodale PM, McDonald SA, Jakubowski M, Burstein R. Revisiting the efficacy of sumatriptan therapy during the aura phase of migraine. Headache. 2009 Jul; 49(7):1001-4. PMID: 19438735; PMCID: PMC2707505.
  78. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941; PMCID: PMC2775514.
  79. Burstein R. Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia? Headache. 2009 Mar; 49(3):364-5. PMID: 19267784.
    View in: PubMed
  80. Burstein R, Dodick D, Silberstein S. Migraine prophylaxis with botulinum toxin A is associated with perception of headache. Toxicon. 2009 Oct; 54(5):624-7. PMID: 19344670; PMCID: PMC2731008.
  81. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799. PMID: 19030105; PMCID: PMC2582961.
  82. Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. Cutaneous allodynia in the migraine population. Ann Neurol. 2008 Feb; 63(2):148-58. PMID: 18059010; PMCID: PMC2729495.
  83. Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22. PMID: 18333963; PMCID: PMC2677814.
  84. Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83. PMID: 17651900; PMCID: PMC2710388.
  85. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    View in: PubMed
  86. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586; PMCID: PMC2045157.
  87. Jakubowski M, McAllister PJ, Bajwa ZH, Ward TN, Smith P, Burstein R. Exploding vs. imploding headache in migraine prophylaxis with Botulinum Toxin A. Pain. 2006 Dec 05; 125(3):286-95. PMID: 17069972; PMCID: PMC1831831.
  88. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    View in: PubMed
  89. Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8. PMID: 16927962.
    View in: PubMed
  90. Burstein R, Jakubowski M. Unitary hypothesis for multiple triggers of the pain and strain of migraine. J Comp Neurol. 2005 Dec 05; 493(1):9-14. PMID: 16258903.
    View in: PubMed
  91. Jakubowski M, Silberstein S, Ashkenazi A, Burstein R. Can allodynic migraine patients be identified interictally using a questionnaire? Neurology. 2005 Nov 08; 65(9):1419-22. PMID: 16275830.
    View in: PubMed
  92. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    View in: PubMed
  93. Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61. PMID: 15985101.
    View in: PubMed
  94. Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60. PMID: 16141951.
    View in: PubMed
  95. Burstein R, Jakubowski M. Implications of multimechanism therapy: when to treat? Neurology. 2005 May 24; 64(10 Suppl 2):S16-20. PMID: 15911782.
    View in: PubMed
  96. Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8. PMID: 15836966.
    View in: PubMed
  97. Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25. PMID: 15362156.
    View in: PubMed
  98. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9. PMID: 15016917; PMCID: PMC384731.
  99. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol. 2004 Jan; 55(1):27-36. PMID: 14705109.
    View in: PubMed
  100. Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004 Jan; 55(1):19-26. PMID: 14705108.
    View in: PubMed
  101. Yarnitsky D, Goor-Aryeh I, Bajwa ZH, Ransil BI, Cutrer FM, Sottile A, Burstein R. 2003 Wolff Award: Possible parasympathetic contributions to peripheral and central sensitization during migraine. Headache. 2003 Jul-Aug; 43(7):704-14. PMID: 12890124.
    View in: PubMed
  102. Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9930-5. PMID: 11504950; PMCID: PMC55555.
  103. Burstein R. Deconstructing migraine headache into peripheral and central sensitization. Pain. 2001 Jan; 89(2-3):107-10. PMID: 11166465.
    View in: PubMed
  104. Malick A, Strassman RM, Burstein R. Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat. J Neurophysiol. 2000 Oct; 84(4):2078-112. PMID: 11024099.
    View in: PubMed
  105. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000 Aug; 123 ( Pt 8):1703-9. PMID: 10908199.
    View in: PubMed
  106. Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000 May; 47(5):614-24. PMID: 10805332.
    View in: PubMed
  107. Malick A, Burstein R. Peripheral and central sensitization during migraine. Funct Neurol. 2000; 15 Suppl 3:28-35. PMID: 11200798.
    View in: PubMed
  108. Yamamura H, Malick A, Chamberlin NL, Burstein R. Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. J Neurophysiol. 1999 Feb; 81(2):479-93. PMID: 10036252.
    View in: PubMed
  109. Malick A, Burstein R. Cells of origin of the trigeminohypothalamic tract in the rat. J Comp Neurol. 1998 Oct 12; 400(1):125-44. PMID: 9762871.
    View in: PubMed
  110. Burstein R, Yamamura H, Malick A, Strassman AM. Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons. J Neurophysiol. 1998 Feb; 79(2):964-82. PMID: 9463456.
    View in: PubMed
  111. Strassman AM, Raymond SA, Burstein R. Sensitization of meningeal sensory neurons and the origin of headaches. Nature. 1996 Dec 12; 384(6609):560-4. PMID: 8955268.
    View in: PubMed
  112. Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. PMID: 8889944.
    View in: PubMed
  113. Burstein R. Somatosensory and visceral input to the hypothalamus and limbic system. Prog Brain Res. 1996; 107:257-67. PMID: 8782524.
    View in: PubMed
  114. Fields HL, Malick A, Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol. 1995 Oct; 74(4):1742-59. PMID: 8989409.
    View in: PubMed
  115. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. PMID: 8152426.
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  116. Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. PMID: 8294956.
    View in: PubMed
  117. Burstein R, Potrebic S. Retrograde labeling of neurons in the spinal cord that project directly to the amygdala or the orbital cortex in the rat. J Comp Neurol. 1993 Sep 22; 335(4):469-85. PMID: 8227531.
    View in: PubMed
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