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Efi G. Kokkotou, Sc.D., Ph.D., M.D.

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  1. R21TR001753 (KOKKOTOU, EFI G.) Sep 1, 2016 - Jul 31, 2018
    NIH/NCATS
    Pre-clinical evaluation of a neutrophil elastase inhibitor for the treatment of inflammatory bowel disease
    Role: Principal Investigator
  2. R01AT004662 (KOKKOTOU, EFI G.) May 1, 2009 - Apr 30, 2014
    NIH/NCCIH
    Omics and Variable Responses to Placebo and Acupuncture in Irritable Bowel Syndro
    Role: Co-Principal Investigator
  3. R01DK080058 (KOKKOTOU, EFI G.) Jul 1, 2008 - Apr 30, 2014
    NIH/NIDDK
    Melanin-Concentrating Hormone as a Novel Mediator of Intestinal Inflammation
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rankin CR, Theodorou E, Law IKM, Rowe L, Kokkotou E, Pekow J, Wang J, Martin MG, Pothoulakis C, Padua DM. Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2018 Jun 28. PMID: 29953254.
    View in: PubMed
  2. Abou-Donia MB, Conboy LA, Kokkotou E, Jacobson E, Elmasry EM, Elkafrawy P, Neely M, Bass CR', Sullivan K. Screening for novel central nervous system biomarkers in veterans with Gulf War Illness. Neurotoxicol Teratol. 2017 05; 61:36-46. PMID: 28286177.
    View in: PubMed
  3. Bai A, Kokkotou E, Zheng Y, Robson SC. Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses. Cell Death Dis. 2015 Jul 23; 6:e1828. PMID: 26203857; PMCID: PMC4650726.
    View in: PubMed, PubMed Central
  4. Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D. A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Inflamm Bowel Dis. 2015 May; 21(5):996-1005. PMID: 25738378; PMCID: PMC4402238.
    View in: PubMed, PubMed Central
  5. Leal EC, Carvalho E, Tellechea A, Kafanas A, Tecilazich F, Kearney C, Kuchibhotla S, Auster ME, Kokkotou E, Mooney DJ, LoGerfo FW, Pradhan-Nabzdyk L, Veves A. Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol. 2015 Jun; 185(6):1638-48. PMID: 25871534; PMCID: PMC4450333.
    View in: PubMed, PubMed Central
  6. Hall KT, Tolkin BR, Chinn GM, Kirsch I, Kelley JM, Lembo AJ, Kaptchuk TJ, Kokkotou E, Davis RB, Conboy LA. Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients. Brain Behav. 2015 Jan; 5(1):39-44. PMID: 25722948; PMCID: PMC4321393.
    View in: PubMed, PubMed Central
  7. Bai A, Moss A, Kokkotou E, Usheva A, Sun X, Cheifetz A, Zheng Y, Longhi MS, Gao W, Wu Y, Robson SC. CD39 and CD161 modulate Th17 responses in Crohn's disease. J Immunol. 2014 Oct 01; 193(7):3366-77. PMID: 25172498; PMCID: PMC4170017.
    View in: PubMed, PubMed Central
  8. Ziogas DC, Karagiannis AK, Geiger BM, Gras-Miralles B, Najarian R, Reizes O, Fitzpatrick LR, Kokkotou E. Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10. Peptides. 2014 May; 55:58-64. PMID: 24556508; PMCID: PMC4004662.
    View in: PubMed, PubMed Central
  9. Geiger BM, Gras-Miralles B, Ziogas DC, Karagiannis AK, Zhen A, Fraenkel P, Kokkotou E. Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish. PLoS One. 2013; 8(12):e83194. PMID: 24376661; PMCID: PMC3869761.
    View in: PubMed, PubMed Central
  10. Chandrasekharan B, Jeppsson S, Pienkowski S, Belsham DD, Sitaraman SV, Merlin D, Kokkotou E, Nusrat A, Tansey MG, Srinivasan S. Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility. Inflamm Bowel Dis. 2013 Nov; 19(12):2535-46. PMID: 24108115; PMCID: PMC4180268.
    View in: PubMed, PubMed Central
  11. Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology. 2013 Oct; 145(4):842-52.e2. PMID: 23856509; PMCID: PMC4427058.
    View in: PubMed, PubMed Central
  12. Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G876-84. PMID: 23538494; PMCID: PMC3652072.
    View in: PubMed, PubMed Central
  13. Karagiannis AK, Ziogas DC, Gras-Miralles B, Geiger BM, Nagel J, Trebicka E, Najarian R, Cherayil BJ, Kokkotou E. Increased susceptibility of melanin-concentrating hormone-deficient mice to infection with Salmonella enterica serovar Typhimurium. Infect Immun. 2013 Jan; 81(1):166-72. PMID: 23115043; PMCID: PMC3536128.
    View in: PubMed, PubMed Central
  14. Hall KT, Lembo AJ, Kirsch I, Ziogas DC, Douaiher J, Jensen KB, Conboy LA, Kelley JM, Kokkotou E, Kaptchuk TJ. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One. 2012; 7(10):e48135. PMID: 23110189; PMCID: PMC3479140.
    View in: PubMed, PubMed Central
  15. Wu W, Robinson-Bostom L, Kokkotou E, Jung HY, Kroumpouzos G. Dyslipidemia in granuloma annulare: a case-control study. Arch Dermatol. 2012 Oct; 148(10):1131-6. PMID: 22710282.
    View in: PubMed
  16. Nagel JM, Geiger BM, Karagiannis AK, Gras-Miralles B, Horst D, Najarian RM, Ziogas DC, Chen X, Kokkotou E. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone. PLoS One. 2012; 7(7):e41914. PMID: 22848656; PMCID: PMC3407051.
    View in: PubMed, PubMed Central
  17. Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 2012 May; 26(5):2187-96. PMID: 22331196; PMCID: PMC3336788.
    View in: PubMed, PubMed Central
  18. Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Margolis KG, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C. Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology. 2011 Dec; 152(12):4571-80. PMID: 22009727; PMCID: PMC3230056.
    View in: PubMed, PubMed Central
  19. Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuño M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 2011 Jun; 152(6):2197-205. PMID: 21467195; PMCID: PMC3100617.
    View in: PubMed, PubMed Central
  20. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010 Dec 22; 5(12):e15591. PMID: 21203519; PMCID: PMC3008733.
    View in: PubMed, PubMed Central
  21. Wang Y, Ziogas DC, Biddinger S, Kokkotou E. You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. Gut. 2010 Dec; 59(12):1625-34. PMID: 20966023; PMCID: PMC3056117.
    View in: PubMed, PubMed Central
  22. Chaniotou Z, Giannogonas P, Theoharis S, Teli T, Gay J, Savidge T, Koutmani Y, Brugni J, Kokkotou E, Pothoulakis C, Karalis KP. Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology. 2010 Dec; 139(6):2083-92. PMID: 20732324.
    View in: PubMed
  23. Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem. 2010 Jun 25; 285(26):20202-12. PMID: 20363741; PMCID: PMC2888433.
    View in: PubMed, PubMed Central
  24. Cremonini F, Ziogas DC, Chang HY, Kokkotou E, Kelley JM, Conboy L, Kaptchuk TJ, Lembo AJ. Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010 Jul; 32(1):29-42. PMID: 20353496; PMCID: PMC3150180.
    View in: PubMed, PubMed Central
  25. Kokkotou E, Conboy LA, Ziogas DC, Quilty MT, Kelley JM, Davis RB, Lembo AJ, Kaptchuk TJ. Serum correlates of the placebo effect in irritable bowel syndrome. Neurogastroenterol Motil. 2010 Mar; 22(3):285-e81. PMID: 20028464; PMCID: PMC2852478.
    View in: PubMed, PubMed Central
  26. Conboy LA, Macklin E, Kelley J, Kokkotou E, Lembo A, Kaptchuk T. Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship. Soc Sci Med. 2010 Feb; 70(3):479-484. PMID: 19900742.
    View in: PubMed
  27. Chandras C, Koutmani Y, Kokkotou E, Pothoulakis C, Karalis KP. Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes. Endocrinology. 2009 Oct; 150(10):4606-14. PMID: 19628576; PMCID: PMC2754688.
    View in: PubMed, PubMed Central
  28. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23. PMID: 19482027; PMCID: PMC2777664.
    View in: PubMed, PubMed Central
  29. Kokkotou E, Espinoza DO, Torres D, Karagiannides I, Kosteletos S, Savidge T, O'Brien M, Pothoulakis C. Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice. Gut. 2009 Jan; 58(1):34-40. PMID: 18824554; PMCID: PMC3058236.
    View in: PubMed, PubMed Central
  30. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4. PMID: 18719589; PMCID: PMC2745972.
    View in: PubMed, PubMed Central
  31. Kokkotou E, Moss AC, Torres D, Karagiannides I, Cheifetz A, Liu S, O'Brien M, Maratos-Flier E, Pothoulakis C. Melanin-concentrating hormone as a mediator of intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10613-8. PMID: 18650383; PMCID: PMC2492477.
    View in: PubMed, PubMed Central
  32. Geiger BM, Behr GG, Frank LE, Caldera-Siu AD, Beinfeld MC, Kokkotou EG, Pothos EN. Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB J. 2008 Aug; 22(8):2740-6. PMID: 18477764; PMCID: PMC2728544.
    View in: PubMed, PubMed Central
  33. Gay J, Kokkotou E, O'Brien M, Pothoulakis C, Karalis KP. Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. Endocrinology. 2008 Jul; 149(7):3403-9. PMID: 18403481; PMCID: PMC2453096.
    View in: PubMed, PubMed Central
  34. Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BH, Nguyen LT, Park M, Rivers AL, McManus C, Kokkotou E, Drossman DA, Goldman P, Lembo AJ. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ. 2008 May 03; 336(7651):999-1003. PMID: 18390493; PMCID: PMC2364862.
    View in: PubMed, PubMed Central
  35. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55. PMID: 18325388; PMCID: PMC2359157.
    View in: PubMed, PubMed Central
  36. Kokkotou E, Moss AC, Michos A, Espinoza D, Cloud JW, Mustafa N, O'Brien M, Pothoulakis C, Kelly CP. Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters. Antimicrob Agents Chemother. 2008 Mar; 52(3):1121-6. PMID: 18195066; PMCID: PMC2258528.
    View in: PubMed, PubMed Central
  37. Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007 Aug 10; 282(32):23672-8. PMID: 17556363.
    View in: PubMed
  38. Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C. Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut. 2007 Sep; 56(9):1210-7. PMID: 17412781; PMCID: PMC1954994.
    View in: PubMed, PubMed Central
  39. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9. PMID: 17259374.
    View in: PubMed
  40. Gay J, Kokkotou E, O'Brien M, Pothoulakis C, Karalis KP. Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines. Neuroimmunomodulation. 2006; 13(2):114-21. PMID: 17077645.
    View in: PubMed
  41. Kokkotou E, Torres D, Moss AC, O'Brien M, Grigoriadis DE, Karalis K, Pothoulakis C. Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. J Immunol. 2006 Sep 01; 177(5):3355-61. PMID: 16920976.
    View in: PubMed
  42. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Aug 25; 281(34):24449-54. PMID: 16816386.
    View in: PubMed
  43. Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, McLean P, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology. 2006 May; 130(6):1729-42. PMID: 16697737.
    View in: PubMed
  44. Tritos NA, Kokkotou EG. The physiology and potential clinical applications of ghrelin, a novel peptide hormone. Mayo Clin Proc. 2006 May; 81(5):653-60. PMID: 16706263.
    View in: PubMed
  45. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5207-12. PMID: 16549770; PMCID: PMC1458819.
    View in: PubMed, PubMed Central
  46. Jeon JY, Bradley RL, Kokkotou EG, Marino FE, Wang X, Pissios P, Maratos-Flier E. MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance. Diabetes. 2006 Feb; 55(2):428-34. PMID: 16443777.
    View in: PubMed
  47. Michos A, Gryllos I, Håkansson A, Srivastava A, Kokkotou E, Wessels MR. Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase. J Biol Chem. 2006 Mar 24; 281(12):8216-23. PMID: 16431917.
    View in: PubMed
  48. E. Kokkotou, I. Karagiannides, M. Tansky, N. Giorgadze, M. O’ Brien, S.E. Leeman, J.L. Kirkland, and C.Pothoulakis . Substance P stimulates proinflammatory responses in human mesenteric preadipocytes via neurokinin-1 receptor. PNAS. 2006; 103(13):5207-12.
  49. Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, Lamont JT. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology. 2005 Dec; 129(6):1875-88. PMID: 16344056.
    View in: PubMed
  50. Rhee SH, Im E, Riegler M, Kokkotou E, O'brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13610-5. PMID: 16157881; PMCID: PMC1224619.
    View in: PubMed, PubMed Central
  51. Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem. 2005 Aug 05; 280(31):28507-18. PMID: 15927959.
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  52. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. PMID: 15895078.
    View in: PubMed
  53. Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 2005 May; 54(5):1314-23. PMID: 15855315.
    View in: PubMed
  54. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem. 2005 Jun 03; 280(22):21237-45. PMID: 15767259.
    View in: PubMed
  55. Kokkotou E, Jeon JY, Wang X, Marino FE, Carlson M, Trombly DJ, Maratos-Flier E. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005 Jul; 289(1):R117-24. PMID: 15731402.
    View in: PubMed
  56. Xinhua C, Kokkotou E, Mustafa N, Bhaskar KR, O’Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii anti-inflammatory factor inhibits MAPK activation in colonic epithelial cells and protects against Clostridium difficile toxin A-induced enteritis. Digestive Diseases Week, Chicago IL. 2005.
  57. Kokkotou E, Karagiannides J, Mustafa N, Savidge T, O’Brien M, Kirkland J, Flier J, Maratos-Flier E, Pothoulakis C. . Melanin Concentrating Hormone (MCH) links obesity and inflammation. Digestive Diseases Week, Chicago IL. 2005.
  58. Bradesi S, Kokkotou E, Songi B, Marvison JC, Mittal Y, McRobert J, Ohning G, Pothoulakis C, Mayer EA. Sustained visceral hyperalgesia following chronic psychological stress in rats involves upregulation ofspinal NK-1 receptors. Digestive Diseases Week, Chicago IL. 2005.
  59. Kokkotou E, Winter M, Mustafa N, Torres D, O’Brien M, Karalis K, Pothoulakis C. Astressin 2B, a specific CRH receptor type 2 antagonist, diminishes C. difficile toxin A-mediated intestinal secretion and inflammation. Digestive Diseases Week, Chicago IL. 2005.
  60. Blüher S, Moschos S, Bullen J, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleeman MW, Sleemann MW, Mantzoros CS. Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes. 2004 Nov; 53(11):2787-96. PMID: 15504958.
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  61. Bullen JW, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E662-70. PMID: 15361355.
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  62. Anton PM, O'Brien M, Kokkotou E, Eisenstein B, Michaelis A, Rothstein D, Paraschos S, Kelly CP, Pothoulakis C. Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrob Agents Chemother. 2004 Oct; 48(10):3975-9. PMID: 15388461; PMCID: PMC521872.
    View in: PubMed, PubMed Central
  63. Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol. 2004 Mar; 24(5):1918-29. PMID: 14966273; PMCID: PMC350563.
    View in: PubMed, PubMed Central
  64. Gay J, O’Brien M, Kokkotou E, Pothoulakis C, Karalis K. Evidence for a role of IL-6 in acute TNBS- induced colitis in mice. Digestive Diseases Week, New Orleans LA. 2004.
  65. Blüher S, Ziotopoulou M, Bullen JW, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. 2004 Jan; 53(1):82-90. PMID: 14693701.
    View in: PubMed
  66. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG, Flier JS, Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10085-90. PMID: 12897241; PMCID: PMC187774.
    View in: PubMed, PubMed Central
  67. Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res. 2003 Jan 31; 961(2):255-60. PMID: 12531492.
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  68. Kokkotou E, Marafelia P, Mantzos EI, Tritos NA. Serum monocyte chemoattractant protein-1 is increased in chronic autoimmune thyroiditis. Metabolism. 2002 Nov; 51(11):1489-93. PMID: 12404203.
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  69. Tritos NA, Mastaitis JW, Kokkotou E, Maratos-Flier E. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res. 2001 Mar 23; 895(1-2):160-6. PMID: 11259773.
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  70. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86. PMID: 11160162; PMCID: PMC199192.
    View in: PubMed, PubMed Central
  71. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. 2001 Feb; 142(2):680-6. PMID: 11159839.
    View in: PubMed
  72. Trombly DJ, Kokkotou E, Tarto J,Vezerides P, Pissios P, Maratos-Flier E. Functional Antagonism between MCH and alpha-MSH: An in vitro model. Keystone Symposia, Obesity and the Regulation of Energy Homeostasis, Taos NM. 2001.
  73. Bradley RL, Kokkotou EG, Maratos-Flier E, Cheatham B. Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes. 2000 Jul; 49(7):1073-7. PMID: 10909960.
    View in: PubMed
  74. Kokkotou EG, Sankale JL, Mani I, Gueye-Ndiaye A, Schwartz D, Essex ME, Mboup S, Kanki PJ. In vitro correlates of HIV-2-mediated HIV-1 protection. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6797-802. PMID: 10841574; PMCID: PMC18743.
    View in: PubMed, PubMed Central
  75. Kokkotou E, Mastaitis JW, Qu D, Hoersch D, Slieker L, Bonter K, Tritos NA, Maratos-Flier E. Characterization of [Phe(13), Tyr(19)]-MCH analog binding activity to the MCH receptor. Neuropeptides. 2000 Jun-Aug; 34(3-4):240-7. PMID: 11021987.
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  76. Tritos N, Mastaitis J, Ludwig D, Kulkarni R, Kokkotou E, Flier J, Maratos-Flier T. . The effect of genetic background on the phenotype of MCH transgenic overexpressor mice. ENDO 2000 The Endocrine Society 82nd Annual Meeting, Toronto Canada. 2000.
  77. Green VJ, Kokkotou E, Ladias JA. Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4. J Biol Chem. 1998 Nov 06; 273(45):29950-7. PMID: 9792714.
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  78. Kokkotou E, Philippon V, Guèye-Ndiaye A, Mboup S, Wang WK, Essex M, Kanki P. Role of the CCR5 delta 32 allele in resistance to HIV-1 infection in west Africa. J Hum Virol. 1998 Nov-Dec; 1(7):469-74. PMID: 10195268.
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  79. Sarr AD, Hamel DJ, Thior I, Kokkotou E, Sankalé JL, Marlink RG, Coll-Seck EM, Essex ME, Siby T, NDoye I, Mboup S, Kanki PJ. HIV-1 and HIV-2 dual infection: lack of HIV-2 provirus correlates with low CD4+ lymphocyte counts. AIDS. 1998 Jan 22; 12(2):131-7. PMID: 9468361.
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  80. Syrigou EI, Konstandoulakis MM, Syrigos KN, Kroubouzou H, Kokotou E, Toutouzas P . Non-specific autoantibodies in cardiomyopathies and myocardial infarction. J Clin Lab Immunol. 1995; 46:155-62.
  81. Sorrentino D, Zhou SL, Kokkotou E, Berk PD. Sex differences in hepatic fatty acid uptake reflect a greater affinity of the transport system in females. Am J Physiol. 1992 Sep; 263(3 Pt 1):G380-5. PMID: 1415550.
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