Harvard Catalyst Profiles

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Megan Horn Orzalli


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00AI130258 (ORZALLI, MEGAN HORN) May 1, 2018 - Jan 31, 2022
    Regulation of antiviral immunity at barrier surfaces by interleukin-1 family cytokines
    Role: Principal Investigator
  2. K99AI130258 (ORZALLI, MEGAN HORN) May 1, 2018 - Apr 30, 2020
    Regulation of antiviral immunity at barrier surfaces by interleukin-1 family cytokines
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Orzalli MH, Prochera A, Payne L, Smith A, Garlick JA, Kagan JC. Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Immunity. 2021 07 13; 54(7):1447-1462.e5. PMID: 33979579.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-?B Signaling Adaptation. Cell Rep. 2019 04 23; 27(4):1165-1175.e5. PMID: 31018131.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  3. Orzalli MH. Human Skin Explants Recapitulate Key Features of HSV-1 Infections. J Invest Dermatol. 2019 03; 139(3):519-521. PMID: 30797319.
    Citations: 1     Fields:    Translation:HumansCells
  4. Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Mol Cell. 2018 09 06; 71(5):825-840.e6. PMID: 30100266.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  5. Merkl PE, Orzalli MH, Knipe DM. Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication. J Virol. 2018 05 15; 92(10). PMID: 29491153.
    Citations: 27     Fields:    Translation:HumansCells
  6. Orzalli MH, Kagan JC. Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection. Trends Cell Biol. 2017 11; 27(11):800-809. PMID: 28642032.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  7. Kurt-Jones EA, Orzalli MH, Knipe DM. Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease. Adv Anat Embryol Cell Biol. 2017; 223:49-75. PMID: 28528439.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. Orzalli MH, Broekema NM, Knipe DM. Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types. J Virol. 2016 09 15; 90(18):8351-9. PMID: 27412599.
    Citations: 40     Fields:    Translation:HumansCells
  9. Orzalli MH, Kagan JC. A one-protein signaling pathway in the innate immune system. Sci Immunol. 2016 Aug 19; 1(2):eaah6184. PMID: 28783697.
    Citations: 2     Fields:    
  10. Orzalli MH, Broekema NM, Diner BA, Hancks DC, Elde NC, Cristea IM, Knipe DM. cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1773-81. PMID: 25831530.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  11. Orzalli MH, Knipe DM. Cellular sensing of viral DNA and viral evasion mechanisms. Annu Rev Microbiol. 2014; 68:477-92. PMID: 25002095.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  12. Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13; 156(4):705-16. PMID: 24529375.
    Citations: 100     Fields:    Translation:AnimalsCells
  13. Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM. Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501. PMID: 24198334.
    Citations: 88     Fields:    Translation:HumansCells
  14. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  15. Orzalli MH, DeLuca NA, Knipe DM. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):E3008-17. PMID: 23027953.
    Citations: 220     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.