Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Joan Siefert Brugge, Ph.D.

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Department
Address
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Other Positions
Title
Institution
Department

Mentoring
completed student projects
Identification and characterization of an ovarian cancer stem cell
Summer, 06/17/13 - 08/16/13

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35CA242428 (BRUGGE, JOAN SIEFERT) Sep 1, 2019 - Aug 31, 2026
    NIH/NCI
    Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
    Role: Principal Investigator
  2. R01CA181543 (BRUGGE, JOAN SIEFERT) Apr 17, 2014 - Mar 31, 2019
    NIH/NCI
    Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells
    Role: Principal Investigator
  3. U19CA148065 (HUNTER, DAVID JOHN) Jul 15, 2010 - Jun 30, 2015
    NIH/NCI
    Discovery, Biology and Risk of Inherited Variants in Breast Cancer
    Role: Co-Principal Investigator
  4. R01CA105134 (BRUGGE, JOAN SIEFERT) Sep 30, 2003 - Mar 31, 2013
    NIH/NCI
    Cell Death Regulation in Lumen Formation and Oncogenesis
    Role: Principal Investigator
  5. R13CA096557 (BRUGGE, JOAN SIEFERT) Jul 1, 2002 - Jun 30, 2007
    NIH/NCI
    Signaling by Adhesion Receptors
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS. Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16500-16508. PMID: 32601199.
    Citations:    
  2. Shu S, Wu HJ, Ge JY, Zeid R, Harris IS, Jovanovic B, Murphy K, Wang B, Qiu X, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020 06 18; 78(6):1096-1113.e8. PMID: 32416067.
    Citations:    
  3. Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nat Commun. 2020 04 06; 11(1):1711. PMID: 32249764.
    Citations:    
  4. Harris IS, Brugge JS. United They Stand, Divided They Fall. Cell Metab. 2019 10 01; 30(4):624-625. PMID: 31577930.
    Citations:    
  5. Press MF, Xie B, Davenport S, Zhou Y, Guzman R, Nolan GP, O'Brien N, Palazzolo M, Mak TW, Brugge JS, Slamon DJ. Role for polo-like kinase 4 in mediation of cytokinesis. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11309-11318. PMID: 31097597.
    Citations:    
  6. Zoeller JJ, Vagodny A, Taneja K, Tan BY, O'Brien N, Slamon DJ, Sampath D, Leverson JD, Bronson RT, Dillon DA, Brugge JS. Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo. Mol Cancer Ther. 2019 06; 18(6):1115-1126. PMID: 30962322.
    Citations:    
  7. Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 06 15; 125(12):1963-1972. PMID: 30835824.
    Citations:    
  8. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 05 07; 29(5):1166-1181.e6. PMID: 30799286.
    Citations:    
  9. Iavarone C, Zervantonakis IK, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis UA, Hallberg D, Velculescu VE, Leverson JD, Sampath D, Mills GB, Brugge JS. Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol Cancer Ther. 2019 03; 18(3):642-655. PMID: 30679390.
    Citations:    Fields:    
  10. Walker SJ, Selfors LM, Margolis BL, Brugge JS. CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin. PLoS One. 2018; 13(11):e0207470. PMID: 30440051.
    Citations:    Fields:    
  11. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018 06 11; 33(6):985-1003.e7. PMID: 29805077.
    Citations: 1     Fields:    
  12. Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 2017 12 14; 6. PMID: 29239720.
    Citations:    Fields:    Translation:HumansCells
  13. Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL. Identification of cancer genes that are independent of dominant proliferation and lineage programs. Proc Natl Acad Sci U S A. 2017 12 26; 114(52):E11276-E11284. PMID: 29229826.
    Citations:    Fields:    Translation:HumansCells
  14. Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P. Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett. 2017 10 11; 17(10):6131-6139. PMID: 28933153.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS. Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer. 2017; 3:38. PMID: 28948214.
    Citations:    
  16. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15; 357(6356):1105-1106. PMID: 28912235.
    Citations:    Fields:    
  17. Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nat Commun. 2017 08 28; 8(1):365. PMID: 28848242.
    Citations: 2     Fields:    Translation:Humans
  18. Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566428.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS. Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer. 2017; 3:18. PMID: 28649658.
    Citations: 1     
  20. Coloff JL, Brugge JS. Metabolic changes promote rejection of oncogenic cells. Nat Cell Biol. 2017 Apr 27; 19(5):414-415. PMID: 28446818.
    Citations: 1     Fields:    Translation:HumansCells
  21. Muranen T, Brugge JS. Moving Closer To Victory. Cold Spring Harb Symp Quant Biol. 2016; 81:281-288. PMID: 28416575.
    Citations:    Fields:    Translation:HumansAnimals
  22. Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017 01 10; 8:13989. PMID: 28071763.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Res. 2016 12 15; 76(24):7168-7180. PMID: 27913436.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  24. Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R. Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin Cancer Res. 2017 Mar 01; 23(5):1263-1273. PMID: 27573169.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  25. Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS. Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight. 2016 Jul 07; 1(10). PMID: 27482544.
    Citations: 9     Fields:    
  26. Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM. The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis. Clin Cancer Res. 2016 Dec 15; 22(24):6039-6050. PMID: 27330058.
    Citations: 5     Fields:    Translation:HumansCells
  27. Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS. A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for ß-catenin. Sci Rep. 2016 06 03; 6:27114. PMID: 27255161.
    Citations: 4     Fields:    Translation:HumansCells
  28. Coloff JL, Brugge JS. Coping with the metabolic stress of leaving home. Cell Res. 2016 07; 26(7):757-8. PMID: 27216116.
    Citations:    Fields:    
  29. Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells. Cell Metab. 2016 05 10; 23(5):867-80. PMID: 27133130.
    Citations: 30     Fields:    Translation:HumansCells
  30. Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2016 Apr 01; 30(7):870. PMID: 27036968.
    Citations: 1     Fields:    
  31. Bui DA, Lee W, White AE, Harper JW, Schackmann RC, Overholtzer M, Selfors LM, Brugge JS. Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP. Sci Signal. 2016 Mar 01; 9(417):ra23. PMID: 26933062.
    Citations: 7     Fields:    Translation:HumansCells
  32. Harris IS, Brugge JS. Cancer: The enemy of my enemy is my friend. Nature. 2015 Nov 12; 527(7577):170-1. PMID: 26503052.
    Citations: 11     Fields:    Translation:HumansAnimals
  33. Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nat Commun. 2015 Jun 17; 6:7419. PMID: 26080861.
    Citations: 31     Fields:    Translation:HumansCells
  34. Sever R, Brugge JS. Signal transduction in cancer. Cold Spring Harb Perspect Med. 2015 Apr 01; 5(4). PMID: 25833940.
    Citations: 32     Fields:    Translation:HumansCells
  35. Ng MR, Besser A, Brugge JS, Danuser G. Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife. 2015 Feb 02; 4:e06656. PMID: 25642646.
    Citations: 1     Fields:    
  36. Ng MR, Besser A, Brugge JS, Danuser G. Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife. 2014 Dec 05; 3:e03282. PMID: 25479385.
    Citations: 19     Fields:    Translation:HumansCells
  37. Gallegos LL, Brugge JS. Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis. Dev Cell. 2014 Jul 14; 30(1):3-4. PMID: 25026030.
    Citations:    Fields:    Translation:Humans
  38. Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest. 2014 Jun; 124(6):2611-25. PMID: 24762435.
    Citations: 34     Fields:    Translation:HumansCells
  39. Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D. Oncogene-like induction of cellular invasion from centrosome amplification. Nature. 2014 Jun 05; 510(7503):167-71. PMID: 24739973.
    Citations: 81     Fields:    Translation:HumansCells
  40. Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Sep 1; 27(17):1947. PMID: 24013506.
    Citations:    
  41. Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Aug 01; 27(15):1718-30. PMID: 23913924.
    Citations: 43     Fields:    Translation:HumansCells
  42. Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS. PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. Cancer Cell. 2013 Jun 10; 23(6):753-67. PMID: 23764000.
    Citations: 21     Fields:    Translation:HumansCells
  43. Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013; 15(4):R65. PMID: 23947835.
    Citations: 10     Fields:    Translation:AnimalsCells
  44. Albeck JG, Mills GB, Brugge JS. Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell. 2013 Jan 24; 49(2):249-61. PMID: 23219535.
    Citations: 107     Fields:    Translation:HumansCells
  45. Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13; 22(5):615-30. PMID: 23153535.
    Citations: 49     Fields:    Translation:HumansCells
  46. Ng MR, Besser A, Danuser G, Brugge JS. Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol. 2012 Oct 29; 199(3):545-63. PMID: 23091067.
    Citations: 78     Fields:    Translation:HumansCells
  47. Brugge J. Q&A: Joan Brugge on empowering post-docs. Cancer Discov. 2012 Jul; 2(7):574. PMID: 22787074.
    Citations:    Fields:    Translation:Humans
  48. Brugge JS. Into the deep: Refocusing on 3D. Nat Cell Biol. 2012 Apr 02; 14(4):332. PMID: 22469826.
    Citations: 2     Fields:    
  49. Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal. 2012 Mar 06; 5(214):ra19. PMID: 22394561.
    Citations: 23     Fields:    Translation:HumansCells
  50. Davidowitz RA, Iwanicki MP, Brugge JS. In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis. J Vis Exp. 2012 Feb 17; (60). PMID: 22371143.
    Citations: 13     Fields:    Translation:HumansCells
  51. Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14; 21(2):227-39. PMID: 22340595.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  52. Leung CT, Brugge JS. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature. 2012 Feb 08; 482(7385):410-3. PMID: 22318515.
    Citations: 74     Fields:    Translation:Cells
  53. Grassian AR, Coloff JL, Brugge JS. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harb Symp Quant Biol. 2011; 76:313-24. PMID: 22105806.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  54. Wang L, Brugge JS, Janes KA. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):E803-12. PMID: 21873240.
    Citations: 45     Fields:    Translation:HumansCells
  55. Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011 Aug 15; 25(16):1716-33. PMID: 21852536.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  56. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31; 43(9):869-74. PMID: 21804546.
    Citations: 293     Fields:    Translation:HumansCells
  57. Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Ince T, Brugge JS. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011 Jul; 1(2):144-57. PMID: 22303516.
    Citations: 84     Fields:    Translation:HumansCells
  58. Gallegos L, Ng MR, Brugge JS. The myosin-II-responsive focal adhesion proteome: a tour de force? Nat Cell Biol. 2011 Apr; 13(4):344-6. PMID: 21460805.
    Citations: 4     Fields:    Translation:Cells
  59. Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen KV, Brugge JS, Montell DJ. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011 Apr 01; 25(7):730-41. PMID: 21406550.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  60. Albeck JG, Brugge JS. Uncovering a tumor suppressor for triple-negative breast cancers. Cell. 2011 Mar 04; 144(5):638-40. PMID: 21376226.
    Citations: 7     Fields:    
  61. Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nat Cell Biol. 2011 Mar; 13(3):324-30. PMID: 21336303.
    Citations: 53     Fields:    Translation:HumansCells
  62. Brugge J. At the leading edge of cancer research: an interview with Joan Brugge. Interview by Sarah Allan. Dis Model Mech. 2011 Jan; 4(1):9-11. PMID: 21183482.
    Citations:    Fields:    Translation:Humans
  63. Harrison SC, Brugge JS. Mechanistic biology in the next quarter century. Mol Biol Cell. 2010 Nov 15; 21(22):3799-800. PMID: 21079017.
    Citations: 1     Fields:    
  64. Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS. Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. PLoS One. 2010 Oct 26; 5(10):e13587. PMID: 21049007.
    Citations: 4     Fields:    Translation:HumansCells
  65. Grassian AR, Schafer ZT, Brugge JS. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem. 2011 Jan 07; 286(1):79-90. PMID: 20956544.
    Citations: 17     Fields:    Translation:HumansCells
  66. Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS. PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010 Jul 23; 5(7):e11729. PMID: 20668531.
    Citations: 33     Fields:    Translation:HumansCells
  67. Brugge J. Joan Brugge: running rings around cancer. Interview by Caitlin Sedwick. J Cell Biol. 2010 Jun 14; 189(6):922-3. PMID: 20548098.
    Citations:    Fields:    Translation:Humans
  68. Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C. Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Mol Biol Cell. 2010 Jul 01; 21(13):2355-66. PMID: 20462959.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  69. Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. A structure-guided approach to creating covalent FGFR inhibitors. Chem Biol. 2010 Mar 26; 17(3):285-95. PMID: 20338520.
    Citations: 27     Fields:    Translation:HumansCells
  70. Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS. Identifying single-cell molecular programs by stochastic profiling. Nat Methods. 2010 Apr; 7(4):311-7. PMID: 20228812.
    Citations: 53     Fields:    Translation:HumansCells
  71. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7. PMID: 20194747.
    Citations: 80     Fields:    Translation:HumansCells
  72. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703. PMID: 20133671.
    Citations: 72     Fields:    Translation:Humans
  73. Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Mutant p53 drives invasion by promoting integrin recycling. Cell. 2009 Dec 24; 139(7):1327-41. PMID: 20064378.
    Citations: 272     Fields:    Translation:HumansCells
  74. Leung CT, Brugge JS. Tumor self-seeding: bidirectional flow of tumor cells. Cell. 2009 Dec 24; 139(7):1226-8. PMID: 20064369.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  75. Ng MR, Brugge JS. A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer Cell. 2009 Dec 08; 16(6):455-7. PMID: 19962663.
    Citations: 26     Fields:    Translation:HumansCells
  76. Iwanicki MP, Brugge JS. Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol. 2009; 10(11):244. PMID: 19951400.
    Citations: 4     Fields:    Translation:Humans
  77. Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009 Dec; 11(12):1444-50. PMID: 19935651.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  78. Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Yang GR, Hong KL, Ginther C, Winterhoff B, Gao G, Brugge J, Slamon DJ. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer. 2009 Nov 17; 101(10):1699-708. PMID: 19861960.
    Citations: 38     Fields:    Translation:HumansCells
  79. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 03; 461(7260):109-13. PMID: 19693011.
    Citations: 259     Fields:    Translation:HumansCells
  80. Mouneimne G, Brugge JS. YB-1 translational control of epithelial-mesenchyme transition. Cancer Cell. 2009 May 05; 15(5):357-9. PMID: 19411064.
    Citations: 7     Fields:    Translation:HumansCells
  81. Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res. 2009 Mar 15; 69(6):2244-51. PMID: 19258500.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  82. Overholtzer M, Brugge JS. The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol. 2008 Oct; 9(10):796-809. PMID: 18784728.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  83. Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol. 2008 Sep; 10(9):1027-38. PMID: 19160483.
    Citations: 174     Fields:    Translation:HumansCells
  84. Melani M, Simpson KJ, Brugge JS, Montell D. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr Biol. 2008 Apr 08; 18(7):532-7. PMID: 18394891.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  85. Mailleux AA, Overholtzer M, Brugge JS. [Entosis, a cell death process related to cell cannibalism between tumor cells]. Med Sci (Paris). 2008 Mar; 24(3):246-8. PMID: 18334170.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  86. Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res. 2008 Jan 01; 68(1):18-21. PMID: 18172291.
    Citations: 10     Fields:    Translation:Humans
  87. Schafer ZT, Brugge JS. IL-6 involvement in epithelial cancers. J Clin Invest. 2007 Dec; 117(12):3660-3. PMID: 18060028.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  88. Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 2007 Nov 30; 131(5):966-79. PMID: 18045538.
    Citations: 153     Fields:    Translation:HumansCells
  89. Mailleux AA, Overholtzer M, Brugge JS. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle. 2008 Jan 01; 7(1):57-62. PMID: 18196964.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  90. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ. Engineering tumors with 3D scaffolds. Nat Methods. 2007 Oct; 4(10):855-60. PMID: 17767164.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  91. Mouneimne G, Brugge JS. Tensins: a new switch in cell migration. Dev Cell. 2007 Sep; 13(3):317-9. PMID: 17765673.
    Citations: 7     Fields:    Translation:HumansCells
  92. Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway. Cancer Cell. 2007 Aug; 12(2):104-7. PMID: 17692802.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  93. Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 2007 Aug 02; 448(7153):604-8. PMID: 17637676.
    Citations: 72     Fields:    Translation:HumansCells
  94. Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3787-92. PMID: 17360431.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  95. Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb; 12(2):221-34. PMID: 17276340.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  96. Carroll DK, Brugge JS, Attardi LD. p63, cell adhesion and survival. Cell Cycle. 2007 Feb 01; 6(3):255-61. PMID: 17297292.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  97. Walker SJ, Brugge JS. SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol. 2006 Nov; 8(11):1220-2. PMID: 17077856.
    Citations: 2     Fields:    Translation:AnimalsCells
  98. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12405-10. PMID: 16894141.
    Citations: 310     Fields:    Translation:HumansAnimalsCells
  99. Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006 Jun; 8(6):551-61. PMID: 16715076.
    Citations: 168     Fields:    Translation:HumansCells
  100. Wilsbacher JL, Moores SL, Brugge JS. An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell Commun Signal. 2006 May 18; 4:5. PMID: 16709244.
    Citations: 6     Fields:    
  101. Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res. 2006 Mar; 5(3):599-610. PMID: 16512675.
    Citations: 39     Fields:    Translation:HumansCells
  102. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006 Mar; 24(3):305-16. PMID: 16546099.
    Citations: 57     Fields:    Translation:AnimalsCells
  103. Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol. 2005 Dec 19; 171(6):1023-34. PMID: 16365168.
    Citations: 225     Fields:    Translation:HumansCells
  104. Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 2005 Dec 15; 65(24):11572-80. PMID: 16357167.
    Citations: 32     Fields:    Translation:HumansCells
  105. Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005 Dec 01; 65(23):10992-1000. PMID: 16322248.
    Citations: 187     Fields:    Translation:HumansCells
  106. Yan SR, Joseph RR, Rosen K, Reginato MJ, Jackson A, Allaire N, Brugge JS, Jobin C, Stadnyk AW. Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene. 2005 Sep 29; 24(43):6482-91. PMID: 16007176.
    Citations: 22     Fields:    Translation:AnimalsCells
  107. Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer. 2005 Sep; 5(9):675-88. PMID: 16148884.
    Citations: 415     Fields:    Translation:HumansAnimalsCells
  108. Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS. G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol. 2005 Jun; 25(12):5282-91. PMID: 15923641.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  109. Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol. 2005 Jun; 25(11):4591-601. PMID: 15899862.
    Citations: 73     Fields:    Translation:HumansCells
  110. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005 Apr 21; 46(2):205-17. PMID: 15848800.
    Citations: 99     Fields:    Translation:AnimalsCells
  111. Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol. 2004 Oct; 24(19):8586-99. PMID: 15367678.
    Citations: 41     Fields:    Translation:AnimalsCells
  112. Shaw KR, Wrobel CN, Brugge JS. Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):297-310. PMID: 15838601.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  113. Sgroi DC, Ma XJ, Ryan P, Wang Z, Younger J, Isakoff S, Smith B, Brugge J, Baer TM, Erlander MG. Discovery of new gene expression predictors for adjuvant tamoxifen outcome for breast cancer patients. J Clin Oncol. 2004 Jul 15; 22(14_suppl):9503. PMID: 28016805.
    Citations:    
  114. Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004 Jul 19; 166(2):273-82. PMID: 15249579.
    Citations: 71     Fields:    Translation:AnimalsCells
  115. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004 Jun 03; 23(26):4641-5. PMID: 15064711.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  116. Ma XJ, Wang Z, Ryan PD, Isakoff SJ, Barmettler A, Fuller A, Muir B, Mohapatra G, Salunga R, Tuggle JT, Tran Y, Tran D, Tassin A, Amon P, Wang W, Wang W, Enright E, Stecker K, Estepa-Sabal E, Smith B, Younger J, Balis U, Michaelson J, Bhan A, Habin K, Baer TM, Brugge J, Haber DA, Erlander MG, Sgroi DC. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell. 2004 Jun; 5(6):607-16. PMID: 15193263.
    Citations: 261     Fields:    Translation:HumansCells
  117. Seton-Rogers SE, Brugge JS. ErbB2 and TGF-beta: a cooperative role in mammary tumor progression? Cell Cycle. 2004 May; 3(5):597-600. PMID: 15107620.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  118. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004 Apr 26; 165(2):263-73. PMID: 15117969.
    Citations: 41     Fields:    Translation:HumansCells