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profileDavid Crittenden Hooper, M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease
55 Fruit St
Boston MA 02114
Phone617/726-3812
Fax617/726-7416
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01AI083214     (GILMORE, MICHAEL S)Sep 1, 2009 - Aug 31, 2021
NIH/NIAID
Harvard-wide Program on Antibiotic Resistance
Role: Co-Principal Investigator

R01AI057576     (HOOPER, DAVID C)Jan 1, 2004 - Jun 30, 2019
NIH/NIAID
Plasmid-mediated Quinolone Resistance
Role: Principal Investigator

R37AI023988     (HOOPER, DAVID C)Sep 1, 1986 - Mar 31, 2018
NIH/NIAID
Quinolone and multidrug resistance in Staphylococcus aureus
Role: Principal Investigator

R01AI023988     (HOOPER, DAVID C)Sep 1, 1986 - Mar 31, 2008
NIH/NIAID
Quinolone Resistance Mechanisms in Staphylococcus aureus
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Truong-Bolduc QC, Khan NS, Vyas JM, Hooper DC. Tet38 Efflux Pump Affects Staphylococcus aureus Internalization by Epithelial Cells through Interaction with CD36 and Contributes to Bacterial Escape from Acidic and Nonacidic Phagolysosomes. Infect Immun. 2017 Feb; 85(2). PMID: 27956597.
    View in: PubMed
  2. Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5):1135-1140. PMID: 28096418.
    View in: PubMed
  3. Vinué L, Hooper DC. A simple technique for suppressor detection in Escherichia coli. FEMS Microbiol Lett. 2016 Sep 27. PMID: 27682418.
    View in: PubMed
  4. Hooper DC, Jacoby GA. Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance. Cold Spring Harb Perspect Med. 2016 Sep 01; 6(9). PMID: 27449972.
    View in: PubMed
  5. Obaitan I, Dwyer R, Lipworth AD, Kupper TS, Camargo CA, Hooper DC, Murphy GF, Pallin DJ. Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis. Am J Emerg Med. 2016 Aug; 34(8):1645-52. PMID: 27344098.
    View in: PubMed
  6. Shenoy ES, Lee H, Hou T, Ware W, Ryan EE, Hooper DC, Walensky RP. The Impact of Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus (VRE) Flags on Hospital Operations. Infect Control Hosp Epidemiol. 2016 Jul; 37(7):782-90. PMID: 27019995; PMCID: PMC4920697 [Available on 07/01/17].
  7. Wang Y, Wu X, Chen J, Amin R, Lu M, Bhayana B, Zhao J, Murray CK, Hamblin MR, Hooper DC, Dai T. Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in Biofilms: In Vitro and In Vivo Studies. J Infect Dis. 2016 May 01; 213(9):1380-7. PMID: 26908743; PMCID: PMC4813746 [Available on 05/01/17].
  8. Vinué L, Corcoran MA, Hooper DC, Jacoby GA. Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1. Antimicrob Agents Chemother. 2015 Dec 28; 60(3):1537-45. PMID: 26711751; PMCID: PMC4776012.
  9. Shenoy ES, Lee H, Cotter JA, Ware W, Kelbaugh D, Weil E, Walensky RP, Hooper DC. Impact of rapid screening for discontinuation of methicillin-resistant Staphylococcus aureus contact precautions. Am J Infect Control. 2016 Feb; 44(2):215-21. PMID: 26440593; PMCID: PMC4728016 [Available on 02/01/17].
  10. Chen C, Villet R, Jacoby GA, Hooper DC. Functions of a GyrBA fusion protein and its interaction with QnrB and quinolones. Antimicrob Agents Chemother. 2015 Nov; 59(11):7124-7. PMID: 26324265; PMCID: PMC4604398 [Available on 05/01/16].
  11. Truong-Bolduc QC, Bolduc GR, Medeiros H, Vyas JM, Wang Y, Hooper DC. Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells. Infect Immun. 2015 Nov; 83(11):4362-72. PMID: 26324534; PMCID: PMC4598397.
  12. Paras ML, Shenoy ES, Hsu HE, Walensky RP, Hooper DC. Housestaff Knowledge Related to Urinary Catheter Use and Catheter-Associated Urinary Tract Infections. Infect Control Hosp Epidemiol. 2015 Nov; 36(11):1355-7. PMID: 26278269; PMCID: PMC4615552 [Available on 11/01/16].
  13. Hooper DC, Jacoby GA. Mechanisms of drug resistance: quinolone resistance. Ann N Y Acad Sci. 2015 Sep; 1354:12-31. PMID: 26190223; PMCID: PMC4626314.
  14. Kim ES, Chen C, Braun M, Kim HY, Okumura R, Wang Y, Jacoby GA, Hooper DC. Interactions between QnrB, QnrB mutants, and DNA gyrase. Antimicrob Agents Chemother. 2015 Sep; 59(9):5413-9. PMID: 26100716; PMCID: PMC4538543 [Available on 03/01/16].
  15. Blumenthal KG, Shenoy ES, Varughese CA, Hurwitz S, Hooper DC, Banerji A. Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy. Ann Allergy Asthma Immunol. 2015 Oct; 115(4):294-300.e2. PMID: 26070805; PMCID: PMC4593731 [Available on 10/01/16].
  16. Kwak YG, Jacoby GA, Hooper DC. Effect of Qnr on Plasmid Gyrase Toxins CcdB and ParE. Antimicrob Agents Chemother. 2015 Aug; 59(8):5078-9. PMID: 26055367; PMCID: PMC4505230 [Available on 02/01/16].
  17. Hsu HE, Shenoy ES, Kelbaugh D, Ware W, Lee H, Zakroysky P, Hooper DC, Walensky RP. An electronic surveillance tool for catheter-associated urinary tract infection in intensive care units. Am J Infect Control. 2015 Jun; 43(6):592-9. PMID: 25840717; PMCID: PMC4457697.
  18. Kim ES, Hooper DC. Clinical importance and epidemiology of quinolone resistance. Infect Chemother. 2014 Dec; 46(4):226-38. PMID: 25566402; PMCID: PMC4285002.
  19. Calderwood SB, Hooper DC. In memoriam: Morton N. Swartz. J Infect Dis. 2015 Jan 01; 211(1):1-3. PMID: 25030059.
    View in: PubMed
  20. Hooper DC, Hirsch MS. Reply to Korch. J Infect Dis. 2014 Nov 01; 210(9):1517-8. PMID: 24808388.
    View in: PubMed
  21. Youngster I, Shenoy ES, Hooper DC, Nelson SB. Comparative evaluation of the tolerability of cefazolin and nafcillin for treatment of methicillin-susceptible Staphylococcus aureus infections in the outpatient setting. Clin Infect Dis. 2014 Aug 01; 59(3):369-75. PMID: 24785233; PMCID: PMC4110443.
  22. Blumenthal KG, Shenoy ES, Hurwitz S, Varughese CA, Hooper DC, Banerji A. Effect of a drug allergy educational program and antibiotic prescribing guideline on inpatient clinical providers' antibiotic prescribing knowledge. J Allergy Clin Immunol Pract. 2014 Jul-Aug; 2(4):407-13. PMID: 25017528; PMCID: PMC4309264.
  23. Tavío MM, Jacoby GA, Hooper DC. QnrS1 structure-activity relationships. J Antimicrob Chemother. 2014 Aug; 69(8):2102-9. PMID: 24729602; PMCID: PMC4100707.
  24. Shenoy ES, Paras ML, Noubary F, Walensky RP, Hooper DC. Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review. BMC Infect Dis. 2014 Mar 31; 14:177. PMID: 24678646; PMCID: PMC4230428.
  25. Hwang TJ, Hooper DC. Association between fluoroquinolone resistance and resistance to other antimicrobial agents among Escherichia coli urinary isolates in the outpatient setting: a national cross-sectional study. J Antimicrob Chemother. 2014 Jun; 69(6):1720-2. PMID: 24521853.
    View in: PubMed
  26. Villet RA, Truong-Bolduc QC, Wang Y, Estabrooks Z, Medeiros H, Hooper DC. Regulation of expression of abcA and its response to environmental conditions. J Bacteriol. 2014 Apr; 196(8):1532-9. PMID: 24509312; PMCID: PMC3993360.
  27. Shenoy ES, Noubary F, Kim J, Rosenberg ES, Cotter JA, Lee H, Walensky RP, Hooper DC. Concordance of PCR and culture from nasal swabs for detection of methicillin-resistant Staphylococcus aureus in a setting of concurrent antistaphylococcal antibiotics. J Clin Microbiol. 2014 Apr; 52(4):1235-7. PMID: 24452168; PMCID: PMC3993487.
  28. Truong-Bolduc QC, Villet RA, Estabrooks ZA, Hooper DC. Native efflux pumps contribute resistance to antimicrobials of skin and the ability of Staphylococcus aureus to colonize skin. J Infect Dis. 2014 May 01; 209(9):1485-93. PMID: 24280365; PMCID: PMC3982850.
  29. Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. ACS Chem Biol. 2014 Feb 21; 9(2):459-67. PMID: 24255971; PMCID: PMC3944067.
  30. Hooper DC, Hirsch MS. Novel clostridium botulinum toxin and dual use research of concern issues. J Infect Dis. 2014 Jan 15; 209(2):167. PMID: 24106293; PMCID: PMC3873790.
  31. Kwak YG, Truong-Bolduc QC, Bin Kim H, Song KH, Kim ES, Hooper DC. Association of norB overexpression and fluoroquinolone resistance in clinical isolates of Staphylococcus aureus from Korea. J Antimicrob Chemother. 2013 Dec; 68(12):2766-72. PMID: 23928023; PMCID: PMC3820107.
  32. Kwak YG, Jacoby GA, Hooper DC. Induction of plasmid-carried qnrS1 in Escherichia coli by naturally occurring quinolones and quorum-sensing signal molecules. Antimicrob Agents Chemother. 2013 Aug; 57(8):4031-4. PMID: 23689721; PMCID: PMC3719764.
  33. Shenoy ES, Kim J, Rosenberg ES, Cotter JA, Lee H, Walensky RP, Hooper DC. Discontinuation of contact precautions for methicillin-resistant staphylococcus aureus: a randomized controlled trial comparing passive and active screening with culture and polymerase chain reaction. Clin Infect Dis. 2013 Jul; 57(2):176-84. PMID: 23572482; PMCID: PMC3689342.
  34. Pallin DJ, Binder WD, Allen MB, Lederman M, Parmar S, Filbin MR, Hooper DC, Camargo CA. Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trial. Clin Infect Dis. 2013 Jun; 56(12):1754-62. PMID: 23457080.
    View in: PubMed
  35. Jacoby GA, Hooper DC. Phylogenetic analysis of chromosomally determined qnr and related proteins. Antimicrob Agents Chemother. 2013 Apr; 57(4):1930-4. PMID: 23318805; PMCID: PMC3623327.
  36. Johnson JR, Tchesnokova V, Johnston B, Clabots C, Roberts PL, Billig M, Riddell K, Rogers P, Qin X, Butler-Wu S, Price LB, Aziz M, Nicolas-Chanoine MH, Debroy C, Robicsek A, Hansen G, Urban C, Platell J, Trott DJ, Zhanel G, Weissman SJ, Cookson BT, Fang FC, Limaye AP, Scholes D, Chattopadhyay S, Hooper DC, Sokurenko EV. Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli. J Infect Dis. 2013 Mar 15; 207(6):919-28. PMID: 23288927; PMCID: PMC3571447.
  37. Shenoy ES, Hsu H, Noubary F, Hooper DC, Walensky RP. National survey of infection preventionists: policies for discontinuation of contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus. Infect Control Hosp Epidemiol. 2012 Dec; 33(12):1272-5. PMID: 23143372; PMCID: PMC3496276.
  38. Ding Y, Fu Y, Lee JC, Hooper DC. Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo. J Bacteriol. 2012 Dec; 194(23):6586-93. PMID: 23042988; PMCID: PMC3497520.
  39. Shenoy ES, Walensky RP, Lee H, Orcutt B, Hooper DC. Resource burden associated with contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: the patient access managers' perspective. Infect Control Hosp Epidemiol. 2012 Aug; 33(8):849-52. PMID: 22759555; PMCID: PMC3461826.
  40. Yokoe DS, Khan Y, Olsen MA, Hooper DC, Greenbaum M, Vostok J, Lankiewicz J, Fraser VJ, Stevenson KB. Enhanced surgical site infection surveillance following hysterectomy, vascular, and colorectal surgery. Infect Control Hosp Epidemiol. 2012 Aug; 33(8):768-73. PMID: 22759543.
    View in: PubMed
  41. Hooper DC, DeMaria A, Limbago BM, O'Brien TF, McCaughey B. Antibiotic resistance: how serious is the problem, and what can be done? Clin Chem. 2012 Aug; 58(8):1182-6. PMID: 22634378.
    View in: PubMed
  42. Qualls ML, Mooney MM, Camargo CA, Zucconi T, Hooper DC, Pallin DJ. Emergency department visit rates for abscess versus other skin infections during the emergence of community-associated methicillin-resistant Staphylococcus aureus, 1997-2007. Clin Infect Dis. 2012 Jul; 55(1):103-5. PMID: 22460965.
    View in: PubMed
  43. Bogoch II, Davis BT, Hooper DC. Severe babesiosis in a patient treated with a tumor necrosis factor a antagonist. Clin Infect Dis. 2012 Apr; 54(8):1215-6. PMID: 22354920.
    View in: PubMed
  44. Truong-Bolduc QC, Hsing LC, Villet R, Bolduc GR, Estabrooks Z, Taguezem GF, Hooper DC. Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA. J Bacteriol. 2012 Apr; 194(7):1823-34. PMID: 22287526; PMCID: PMC3302453.
  45. Lankiewicz JD, Yokoe DS, Olsen MA, Onufrak F, Fraser VJ, Stevenson K, Khan Y, Hooper D, Platt R, Huang SS. Beyond 30 days: does limiting the duration of surgical site infection follow-up limit detection? Infect Control Hosp Epidemiol. 2012 Feb; 33(2):202-4. PMID: 22227993; PMCID: PMC3608264.
  46. Calderwood MS, Ma A, Khan YM, Olsen MA, Bratzler DW, Yokoe DS, Hooper DC, Stevenson K, Fraser VJ, Platt R, Huang SS. Use of Medicare diagnosis and procedure codes to improve detection of surgical site infections following hip arthroplasty, knee arthroplasty, and vascular surgery. Infect Control Hosp Epidemiol. 2012 Jan; 33(1):40-9. PMID: 22173521.
    View in: PubMed
  47. Okumura R, Liao CH, Gavin M, Jacoby GA, Hooper DC. Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system. Antimicrob Agents Chemother. 2011 Dec; 55(12):5942-5. PMID: 21930884; PMCID: PMC3232789.
  48. Truong-Bolduc QC, Dunman PM, Eidem T, Hooper DC. Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus. J Bacteriol. 2011 Nov; 193(22):6207-14. PMID: 21908673; PMCID: PMC3209200.
  49. Jacoby GA, Griffin CM, Hooper DC. Citrobacter spp. as a source of qnrB Alleles. Antimicrob Agents Chemother. 2011 Nov; 55(11):4979-84. PMID: 21844311; PMCID: PMC3195048.
  50. Huang SS, Placzek H, Livingston J, Ma A, Onufrak F, Lankiewicz J, Kleinman K, Bratzler D, Olsen MA, Lyles R, Khan Y, Wright P, Yokoe DS, Fraser VJ, Weinstein RA, Stevenson K, Hooper D, Vostok J, Datta R, Nsa W, Platt R. Use of Medicare claims to rank hospitals by surgical site infection risk following coronary artery bypass graft surgery. Infect Control Hosp Epidemiol. 2011 Aug; 32(8):775-83. PMID: 21768761.
    View in: PubMed
  51. Vetting MW, Hegde SS, Wang M, Jacoby GA, Hooper DC, Blanchard JS. Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. J Biol Chem. 2011 Jul 15; 286(28):25265-73. PMID: 21597116; PMCID: PMC3137097.
  52. Truong-Bolduc QC, Bolduc GR, Okumura R, Celino B, Bevis J, Liao CH, Hooper DC. Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin. Antimicrob Agents Chemother. 2011 Jul; 55(7):3214-9. PMID: 21555767; PMCID: PMC3122426.
  53. Didier JP, Villet R, Huggler E, Lew DP, Hooper DC, Kelley WL, Vaudaux P. Impact of ciprofloxacin exposure on Staphylococcus aureus genomic alterations linked with emergence of rifampin resistance. Antimicrob Agents Chemother. 2011 May; 55(5):1946-52. PMID: 21357297; PMCID: PMC3088276.
  54. Kim HB, Park CH, Gavin M, Jacoby GA, Hooper DC. Cold shock induces qnrA expression in Shewanella algae. Antimicrob Agents Chemother. 2011 Jan; 55(1):414-6. PMID: 21078945; PMCID: PMC3019661.
  55. Hyle EP, Ferraro MJ, Silver M, Lee H, Hooper DC. Ertapenem-resistant Enterobacteriaceae: risk factors for acquisition and outcomes. Infect Control Hosp Epidemiol. 2010 Dec; 31(12):1242-9. PMID: 21029005.
    View in: PubMed
  56. Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N Engl J Med. 2010 May 13; 362(19):1804-13. PMID: 20463340; PMCID: PMC3107499.
  57. Truong-Bolduc QC, Hooper DC. Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus. J Bacteriol. 2010 May; 192(10):2525-34. PMID: 20233929; PMCID: PMC2863576.
  58. Kim HB, Wang M, Ahmed S, Park CH, LaRocque RC, Faruque AS, Salam MA, Khan WA, Qadri F, Calderwood SB, Jacoby GA, Hooper DC. Transferable quinolone resistance in Vibrio cholerae. Antimicrob Agents Chemother. 2010 Feb; 54(2):799-803. PMID: 19949057; PMCID: PMC2812163.
  59. Hooper DC, Phares TW, Fabis MJ, Roy A. The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system. PLoS Negl Trop Dis. 2009 Oct 06; 3(10):e535. PMID: 19806203; PMCID: PMC2754506.
  60. Strahilevitz J, Jacoby GA, Hooper DC, Robicsek A. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev. 2009 Oct; 22(4):664-89. PMID: 19822894; PMCID: PMC2772364.
  61. Pallin DJ, Espinola JA, Leung DY, Hooper DC, Camargo CA. Epidemiology of dermatitis and skin infections in United States physicians' offices, 1993-2005. Clin Infect Dis. 2009 Sep 15; 49(6):901-7. PMID: 19663690.
    View in: PubMed
  62. Kim HB, Wang M, Park CH, Kim EC, Jacoby GA, Hooper DC. oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. Antimicrob Agents Chemother. 2009 Aug; 53(8):3582-4. PMID: 19528276; PMCID: PMC2715617.
  63. Bolon MK, Hooper D, Stevenson KB, Greenbaum M, Olsen MA, Herwaldt L, Noskin GA, Fraser VJ, Climo M, Khan Y, Vostok J, Yokoe DS. Improved surveillance for surgical site infections after orthopedic implantation procedures: extending applications for automated data. Clin Infect Dis. 2009 May 01; 48(9):1223-9. PMID: 19335165.
    View in: PubMed
  64. Wang M, Guo Q, Xu X, Wang X, Ye X, Wu S, Hooper DC, Wang M. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother. 2009 May; 53(5):1892-7. PMID: 19258263; PMCID: PMC2681562.
  65. Jacoby GA, Gacharna N, Black TA, Miller GH, Hooper DC. Temporal appearance of plasmid-mediated quinolone resistance genes. Antimicrob Agents Chemother. 2009 Apr; 53(4):1665-6. PMID: 19164145; PMCID: PMC2663075.
  66. Kim HB, Park CH, Kim CJ, Kim EC, Jacoby GA, Hooper DC. Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period. Antimicrob Agents Chemother. 2009 Feb; 53(2):639-45. PMID: 19064896; PMCID: PMC2630623.
  67. Wang M, Jacoby GA, Mills DM, Hooper DC. SOS regulation of qnrB expression. Antimicrob Agents Chemother. 2009 Feb; 53(2):821-3. PMID: 19029320; PMCID: PMC2630627.
  68. Truong-Bolduc QC, Ding Y, Hooper DC. Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus. J Bacteriol. 2008 Nov; 190(22):7375-81. PMID: 18805983; PMCID: PMC2576658.
  69. Ding Y, Onodera Y, Lee JC, Hooper DC. NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses. J Bacteriol. 2008 Nov; 190(21):7123-9. PMID: 18723624; PMCID: PMC2580682.
  70. Vetting MW, Park CH, Hegde SS, Jacoby GA, Hooper DC, Blanchard JS. Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant. Biochemistry. 2008 Sep 16; 47(37):9825-35. PMID: 18710261; PMCID: PMC2855648.
  71. Jacoby G, Cattoir V, Hooper D, Martínez-Martínez L, Nordmann P, Pascual A, Poirel L, Wang M. qnr Gene nomenclature. Antimicrob Agents Chemother. 2008 Jul; 52(7):2297-9. PMID: 18426894; PMCID: PMC2443900.
  72. Pallin DJ, Egan DJ, Pelletier AJ, Espinola JA, Hooper DC, Camargo CA. Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med. 2008 Mar; 51(3):291-8. PMID: 18222564.
    View in: PubMed
  73. Fabis MJ, Scott GS, Kean RB, Koprowski H, Hooper DC. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5656-61. PMID: 17372191; PMCID: PMC1838442.
  74. Truong-Bolduc QC, Hooper DC. The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus. J Bacteriol. 2007 Apr; 189(8):2996-3005. PMID: 17277059; PMCID: PMC1855827.
  75. Bhattacharyya T, Hooper DC. Antibiotic dosing before primary hip and knee replacement as a pay-for-performance measure. J Bone Joint Surg Am. 2007 Feb; 89(2):287-91. PMID: 17272442.
    View in: PubMed
  76. Robicsek A, Jacoby GA, Hooper DC. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis. 2006 Oct; 6(10):629-40. PMID: 17008172.
    View in: PubMed
  77. Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC. Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother. 2006 Nov; 50(11):3953-5. PMID: 16954321; PMCID: PMC1635235.
  78. Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob Agents Chemother. 2006 Aug; 50(8):2872-4. PMID: 16870791; PMCID: PMC1538681.
  79. Gay K, Robicsek A, Strahilevitz J, Park CH, Jacoby G, Barrett TJ, Medalla F, Chiller TM, Hooper DC. Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica. Clin Infect Dis. 2006 Aug 01; 43(3):297-304. PMID: 16804843.
    View in: PubMed
  80. Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, Hooper DC. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother. 2006 Apr; 50(4):1178-82. PMID: 16569827; PMCID: PMC1426915.
  81. Truong-Bolduc QC, Strahilevitz J, Hooper DC. NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Mar; 50(3):1104-7. PMID: 16495280; PMCID: PMC1426456.
  82. Strahilevitz J, Robicsek A, Hooper DC. Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones. Antimicrob Agents Chemother. 2006 Feb; 50(2):600-6. PMID: 16436716; PMCID: PMC1366898.
  83. Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Park CH, Bush K, Hooper DC. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med. 2006 Jan; 12(1):83-8. PMID: 16369542.
    View in: PubMed
  84. Strahilevitz J, Truong-Bolduc QC, Hooper DC. DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrob Agents Chemother. 2005 Dec; 49(12):5051-7. PMID: 16304172; PMCID: PMC1315973.
  85. Strahilevitz J, Onodera Y, Hooper DC. An improved expression plasmid for affinity purification of Staphylococcus aureus gyrase A subunit. Protein Expr Purif. 2006 May; 47(1):10-5. PMID: 16289915.
    View in: PubMed
  86. de Souza NJ, Gupte SV, Deshpande PK, Desai VN, Bhawsar SB, Yeole RD, Shukla MC, Strahilevitz J, Hooper DC, Bozdogan B, Appelbaum PC, Jacobs MR, Shetty N, Patel MV, Jha R, Khorakiwala HF. A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. J Med Chem. 2005 Aug 11; 48(16):5232-42. PMID: 16078842.
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  87. Varghese JC, Hahn PF, Harisinghani MG, Hayat SM, Gervais DA, Hooper DC, Mueller PR. Fungus-infected fluid collections in thorax or abdomen: effectiveness of percutaneous catheter drainage. Radiology. 2005 Aug; 236(2):730-8. PMID: 16040928.
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  88. Robicsek A, Sahm DF, Strahilevitz J, Jacoby GA, Hooper DC. Broader distribution of plasmid-mediated quinolone resistance in the United States. Antimicrob Agents Chemother. 2005 Jul; 49(7):3001-3. PMID: 15980384; PMCID: PMC1168650.
  89. Tran JH, Jacoby GA, Hooper DC. Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV. Antimicrob Agents Chemother. 2005 Jul; 49(7):3050-2. PMID: 15980397; PMCID: PMC1168640.
  90. Hooper DC. Efflux pumps and nosocomial antibiotic resistance: a primer for hospital epidemiologists. Clin Infect Dis. 2005 Jun 15; 40(12):1811-7. PMID: 15909271.
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  91. Strahilevitz J, Hooper DC. Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin. Antimicrob Agents Chemother. 2005 May; 49(5):1949-56. PMID: 15855518; PMCID: PMC1087631.
  92. Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J Bacteriol. 2005 Apr; 187(7):2395-405. PMID: 15774883; PMCID: PMC1065235.
  93. Tran JH, Jacoby GA, Hooper DC. Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrob Agents Chemother. 2005 Jan; 49(1):118-25. PMID: 15616284; PMCID: PMC538914.
  94. Yokoe DS, Noskin GA, Cunnigham SM, Zuccotti G, Plaskett T, Fraser VJ, Olsen MA, Tokars JI, Solomon S, Perl TM, Cosgrove SE, Tilson RS, Greenbaum M, Hooper DC, Sands KE, Tully J, Herwaldt La, Diekema DJ, Wong ES, Climo M, Platt R. Enhanced identification of postoperative infections among inpatients. Emerg Infect Dis. 2004 Nov; 10(11):1924-30. PMID: 15550201; PMCID: PMC3329006.
  95. Ellerin TB, Walsh SR, Hooper DC. Recurrent meningitis of unknown aetiology. Lancet. 2004 May 29; 363(9423):1772. PMID: 15172776.
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  96. Wang M, Sahm DF, Jacoby GA, Zhang Y, Hooper DC. Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr. Antimicrob Agents Chemother. 2004 Apr; 48(4):1400-1. PMID: 15047552; PMCID: PMC375334.
  97. Wang M, Sahm DF, Jacoby GA, Hooper DC. Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. Antimicrob Agents Chemother. 2004 Apr; 48(4):1295-9. PMID: 15047532; PMCID: PMC375335.
  98. Bisognano C, Kelley WL, Estoppey T, Francois P, Schrenzel J, Li D, Lew DP, Hooper DC, Cheung AL, Vaudaux P. A recA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureus. J Biol Chem. 2004 Mar 05; 279(10):9064-71. PMID: 14699158.
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  99. Ince D, Hooper DC. Quinolone resistance due to reduced target enzyme expression. J Bacteriol. 2003 Dec; 185(23):6883-92. PMID: 14617652; PMCID: PMC262703.
  100. Weber SG, Gold HS, Hooper DC, Karchmer AW, Carmeli Y. Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis. 2003 Nov; 9(11):1415-22. PMID: 14718085; PMCID: PMC3035560.
  101. Sands KE, Yokoe DS, Hooper DC, Tully JL, Horan TC, Gaynes RP, Solomon SL, Platt R. Detection of postoperative surgical-site infections: comparison of health plan-based surveillance with hospital-based programs. Infect Control Hosp Epidemiol. 2003 Oct; 24(10):741-3. PMID: 14587934.
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  102. Wang M, Tran JH, Jacoby GA, Zhang Y, Wang F, Hooper DC. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob Agents Chemother. 2003 Jul; 47(7):2242-8. PMID: 12821475; PMCID: PMC161834.
  103. Truong-Bolduc QC, Zhang X, Hooper DC. Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. J Bacteriol. 2003 May; 185(10):3127-38. PMID: 12730173; PMCID: PMC154082.
  104. Ince D, Zhang X, Hooper DC. Activity of and resistance to moxifloxacin in Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Apr; 47(4):1410-5. PMID: 12654680; PMCID: PMC152517.
  105. Ince D, Zhang X, Silver LC, Hooper DC. Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Jan; 47(1):274-82. PMID: 12499202; PMCID: PMC149033.
  106. Ince D, Zhang X, Silver LC, Hooper DC. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov; 46(11):3370-80. PMID: 12384338; PMCID: PMC128724.
  107. Hooper DC. Fluoroquinolone resistance among Gram-positive cocci. Lancet Infect Dis. 2002 Sep; 2(9):530-8. PMID: 12206969.
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  108. Mandell LA, Peterson LR, Wise R, Hooper D, Low DE, Schaad UB, Klugman KP, Courvalin P. The battle against emerging antibiotic resistance: should fluoroquinolones be used to treat children? Clin Infect Dis. 2002 Sep 15; 35(6):721-7. PMID: 12203170.
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  109. Yu JL, Grinius L, Hooper DC. NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomes. J Bacteriol. 2002 Mar; 184(5):1370-7. PMID: 11844766; PMCID: PMC134835.
  110. Lawrence LE, Frosco M, Ryan B, Chaniewski S, Yang H, Hooper DC, Barrett JF. Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations. Antimicrob Agents Chemother. 2002 Jan; 46(1):191-5. PMID: 11751133; PMCID: PMC126973.
  111. Ince D, Hooper DC. Mechanisms and frequency of resistance to gatifloxacin in comparison to AM-1121 and ciprofloxacin in Staphylococcus aureus. Antimicrob Agents Chemother. 2001 Oct; 45(10):2755-64. PMID: 11557465; PMCID: PMC90727.
  112. Hooper DC. Minimizing potential resistance: the molecular view--a comment on Courvalin and Trieu-Cuot. Clin Infect Dis. 2001 Sep 15; 33 Suppl 3:S157-60. PMID: 11524713.
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  113. Zachary KC, Bayne PS, Morrison VJ, Ford DS, Silver LC, Hooper DC. Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci. Infect Control Hosp Epidemiol. 2001 Sep; 22(9):560-4. PMID: 11732785.
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  114. Fournier B, Truong-Bolduc QC, Zhang X, Hooper DC. A mutation in the 5' untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus. J Bacteriol. 2001 Apr; 183(7):2367-71. PMID: 11244079; PMCID: PMC95146.
  115. Hooper DC. Mechanisms of action of antimicrobials: focus on fluoroquinolones. Clin Infect Dis. 2001 Mar 15; 32 Suppl 1:S9-S15. PMID: 11249823.
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  116. Hooper DC. Emerging mechanisms of fluoroquinolone resistance. Emerg Infect Dis. 2001 Mar-Apr; 7(2):337-41. PMID: 11294736; PMCID: PMC2631735.
  117. Nigri GR, Tsai S, Kossodo S, Waterman P, Fungaloi P, Hooper DC, Doukas AG, LaMuraglia GM. Laser-induced shock waves enhance sterilization of infected vascular prosthetic grafts. Lasers Surg Med. 2001; 29(5):448-54. PMID: 11891733.
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  118. Ince D, Hooper DC. Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Antimicrob Agents Chemother. 2000 Dec; 44(12):3344-50. PMID: 11083638; PMCID: PMC90203.
  119. Catalano OA, Hahn PF, Hooper DC, Mueller PR. Efficacy of percutaneous abscess drainage in patients with vancomycin-resistant enterococci. AJR Am J Roentgenol. 2000 Aug; 175(2):533-6. PMID: 10915709.
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  120. Fournier B, Zhao X, Lu T, Drlica K, Hooper DC. Selective targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: different patterns of quinolone-induced inhibition of DNA synthesis. Antimicrob Agents Chemother. 2000 Aug; 44(8):2160-5. PMID: 10898691; PMCID: PMC90029.
  121. Hooper DC. Mechanisms of action and resistance of older and newer fluoroquinolones. Clin Infect Dis. 2000 Aug; 31 Suppl 2:S24-8. PMID: 10984324.
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  122. Fournier B, Hooper DC. A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus. J Bacteriol. 2000 Jul; 182(14):3955-64. PMID: 10869073; PMCID: PMC94580.
  123. Hooper DC. New uses for new and old quinolones and the challenge of resistance. Clin Infect Dis. 2000 Feb; 30(2):243-54. PMID: 10671323.
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  124. Fournier B, Aras R, Hooper DC. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system. J Bacteriol. 2000 Feb; 182(3):664-71. PMID: 10633099; PMCID: PMC94328.
  125. Hooper DC. The fluoroquinolones after ciprofloxacin and ofloxacin. Curr Clin Top Infect Dis. 2000; 20:63-91. PMID: 10943519.
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  126. Fournier B, Gravel A, Hooper DC, Roy PH. Strength and regulation of the different promoters for chromosomal beta-lactamases of Klebsiella oxytoca. Antimicrob Agents Chemother. 1999 Apr; 43(4):850-5. PMID: 10103190; PMCID: PMC89216.
  127. Hooper DC. Mechanisms of fluoroquinolone resistance. Drug Resist Updat. 1999 Feb; 2(1):38-55. PMID: 11504468.
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  128. Hooper DC. Mode of action of fluoroquinolones. Drugs. 1999; 58 Suppl 2:6-10. PMID: 10553698.
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  129. Hooper DC. Clinical applications of quinolones. Biochim Biophys Acta. 1998 Oct 01; 1400(1-3):45-61. PMID: 9748496.
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  130. Hooper DC. Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance. Clin Infect Dis. 1998 Aug; 27 Suppl 1:S54-63. PMID: 9710672.
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  131. Fournier B, Hooper DC. Effects of mutations in GrlA of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity. Antimicrob Agents Chemother. 1998 Aug; 42(8):2109-12. PMID: 9687416; PMCID: PMC105875.
  132. Ng EW, Samiy N, Ruoff KL, Cousins FV, Hooper DC, von Gunten S, D'Amico DJ, Baker AS. Treatment of experimental Staphylococcus epidermidis endophthalmitis with oral trovafloxacin. Am J Ophthalmol. 1998 Aug; 126(2):278-87. PMID: 9727522.
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  133. Kontoyiannis DP, Ruoff K, Hooper DC. Nocardia bacteremia. Report of 4 cases and review of the literature. Medicine (Baltimore). 1998 Jul; 77(4):255-67. PMID: 9715730.
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  134. Fridkin SK, Yokoe DS, Whitney CG, Onderdonk A, Hooper DC. Epidemiology of a dominant clonal strain of vancomycin-resistant Enterococcus faecium at separate hospitals in Boston, Massachusetts. J Clin Microbiol. 1998 Apr; 36(4):965-70. PMID: 9542917; PMCID: PMC104669.
  135. Hooper DC. Structure of grepafloxacin relative to activity and safety profile. Clin Microbiol Infect. 1998 Mar; 4 Suppl 1:S15-S20. PMID: 11869245.
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  136. Fournier B, Hooper DC. Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity. Antimicrob Agents Chemother. 1998 Jan; 42(1):121-8. PMID: 9449271; PMCID: PMC105466.
  137. Pegues DA, Colby C, Hibberd PL, Cohen LG, Ausubel FM, Calderwood SB, Hooper DC. The epidemiology of resistance to ofloxacin and oxacillin among clinical coagulase-negative staphylococcal isolates: analysis of risk factors and strain types. Clin Infect Dis. 1998 Jan; 26(1):72-9. PMID: 9455512.
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  138. Pegues DA, Pegues CF, Hibberd PL, Ford DS, Hooper DC. Emergence and dissemination of a highly vancomycin-resistant vanA strain of Enterococcus faecium at a large teaching hospital. J Clin Microbiol. 1997 Jun; 35(6):1565-70. PMID: 9163483; PMCID: PMC229788.
  139. Breines DM, Ouabdesselam S, Ng EY, Tankovic J, Shah S, Soussy CJ, Hooper DC. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob Agents Chemother. 1997 Jan; 41(1):175-9. PMID: 8980775; PMCID: PMC163680.
  140. Threlkeld SC, Hooper DC. Update on management of patients with Nocardia infection. Curr Clin Top Infect Dis. 1997; 17:1-23. PMID: 9189658.
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  141. Ng EY, Trucksis M, Hooper DC. Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother. 1996 Aug; 40(8):1881-8. PMID: 8843298; PMCID: PMC163434.
  142. Pegues CF, Pegues DA, Ford DS, Hibberd PL, Carson LA, Raine CM, Hooper DC. Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak. Epidemiol Infect. 1996 Jun; 116(3):309-17. PMID: 8666075; PMCID: PMC2271439.
  143. Chen NT, Butler PE, Hooper DC, May JW. Bacterial growth in saline implants: in vitro and in vivo studies. Ann Plast Surg. 1996 Apr; 36(4):337-41. PMID: 8728573.
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  144. Hooper DC. From fluoroquinolones to 2-pyridones. Lancet. 1995 May 13; 345(8959):1192-3. PMID: 7739303.
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  145. Hooper DC. Quinolone mode of action. Drugs. 1995; 49 Suppl 2:10-5. PMID: 8549276.
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  146. Hooper DC. Bacterial resistance to fluoroquinolones: mechanisms and patterns. Adv Exp Med Biol. 1995; 390:49-57. PMID: 8718601.
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  147. Ng EY, Trucksis M, Hooper DC. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob Agents Chemother. 1994 Jun; 38(6):1345-55. PMID: 8092836; PMCID: PMC188209.
  148. Chen NT, Hong HZ, Hooper DC, May JW. The effect of systemic antibiotic and antibiotic-impregnated polymethylmethacrylate beads on the bacterial clearance in wounds containing contaminated dead bone. Plast Reconstr Surg. 1993 Dec; 92(7):1305-11; discussion 1312-3. PMID: 8248406.
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  149. Hooper DC. Quinolone mode of action--new aspects. Drugs. 1993; 45 Suppl 3:8-14. PMID: 7689456.
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  150. Hooper DC, Wolfson JS, Bozza MA, Ng EY. Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxB. Antimicrob Agents Chemother. 1992 May; 36(5):1151-4. PMID: 1510409; PMCID: PMC188855.
  151. Wolfson JS, Hooper DC. Overview of fluoroquinolone safety. Am J Med. 1991 Dec 30; 91(6A):153S-161S. PMID: 1767803.
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  152. Trucksis M, Wolfson JS, Hooper DC. A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus. J Bacteriol. 1991 Sep; 173(18):5854-60. PMID: 1653224; PMCID: PMC208319.
  153. Wolfson JS, Hooper DC. Pharmacokinetics of quinolones: newer aspects. Eur J Clin Microbiol Infect Dis. 1991 Apr; 10(4):267-74. PMID: 1864287.
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  154. Hooper DC, Wolfson JS. Mode of action of the new quinolones: new data. Eur J Clin Microbiol Infect Dis. 1991 Apr; 10(4):223-31. PMID: 1650698.
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  155. Hooper DC, Wolfson JS. Fluoroquinolone antimicrobial agents. N Engl J Med. 1991 Feb 07; 324(6):384-94. PMID: 1987461.
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  156. Wolfson JS, Hooper DC, McHugh GL, Bozza MA, Swartz MN. Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents. Antimicrob Agents Chemother. 1990 Oct; 34(10):1938-43. PMID: 1963289; PMCID: PMC171968.
  157. Masem M, Greenberg BM, Hoffman C, Hooper DC, May JW. Comparative bacterial clearances of muscle and skin/subcutaneous tissues with and without dead bone: a laboratory study. Plast Reconstr Surg. 1990 May; 85(5):773-81. PMID: 2095746.
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  158. Hooper DC, Wolfson JS. Bacterial resistance to the quinolone antimicrobial agents. Am J Med. 1989 Dec 29; 87(6C):17S-23S. PMID: 2690616.
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  159. Wolfson JS, Hooper DC. Comparative pharmacokinetics of ofloxacin and ciprofloxacin. Am J Med. 1989 Dec 29; 87(6C):31S-36S. PMID: 2690617.
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  160. Hooper DC, Wolfson JS. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects. Antimicrob Agents Chemother. 1989 Oct; 33(10):1662-7. PMID: 2686546; PMCID: PMC172734.
  161. Wolfson JS, Hooper DC. Fluoroquinolone antimicrobial agents. Clin Microbiol Rev. 1989 Oct; 2(4):378-424. PMID: 2680058; PMCID: PMC358131.
  162. Wolfson JS, Hooper DC. Treatment of genitourinary tract infections with fluoroquinolones: activity in vitro, pharmacokinetics, and clinical efficacy in urinary tract infections and prostatitis. Antimicrob Agents Chemother. 1989 Oct; 33(10):1655-61. PMID: 2686545; PMCID: PMC172733.
  163. Wolfson JS, Hooper DC. Bacterial resistance to quinolones: mechanisms and clinical importance. Rev Infect Dis. 1989 Jul-Aug; 11 Suppl 5:S960-8. PMID: 2549610.
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  164. Hooper DC, Wolfson JS. Mode of action of the quinolone antimicrobial agents: review of recent information. Rev Infect Dis. 1989 Jul-Aug; 11 Suppl 5:S902-11. PMID: 2549608.
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  165. Wolfson JS, Hooper DC, Shih DJ, McHugh GL, Swartz MN. Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones. Antimicrob Agents Chemother. 1989 May; 33(5):705-9. PMID: 2665642; PMCID: PMC172518.
  166. Hooper DC, Wolfson JS, Tung C, Souza KS, Swartz MN. Effects of inhibition of the B subunit of DNA gyrase on conjugation in Escherichia coli. J Bacteriol. 1989 Apr; 171(4):2235-7. PMID: 2539364; PMCID: PMC209885.
  167. Hooper DC, Wolfson JS, Souza KS, Ng EY, McHugh GL, Swartz MN. Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation. Antimicrob Agents Chemother. 1989 Mar; 33(3):283-90. PMID: 2658782; PMCID: PMC171480.
  168. Kerschmann RL, Wolfson JS, McHugh GL, Dickersin GR, Hooper DC, Swartz MN. Novobiocin-induced ultrastructural changes and antagonism of DNA synthesis in Trypanosoma cruzi amastigotes growing in cell-free medium. J Protozool. 1989 Jan-Feb; 36(1):14-20. PMID: 2651651.
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  169. Madoff S, Hooper DC. Nongenitourinary infections caused by Mycoplasma hominis in adults. Rev Infect Dis. 1988 May-Jun; 10(3):602-13. PMID: 3293162.
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  170. Wolfson JS, Hooper DC. Norfloxacin: a new targeted fluoroquinolone antimicrobial agent. Ann Intern Med. 1988 Feb; 108(2):238-51. PMID: 3277508.
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  171. Hooper DC, Wolfson JS. Mode of action of the quinolone antimicrobial agents. Rev Infect Dis. 1988 Jan-Feb; 10 Suppl 1:S14-21. PMID: 2831608.
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  172. Wolfson JS, Hooper DC, Ng EY, Souza KS, McHugh GL, Swartz MN. Antagonism of wild-type and resistant Escherichia coli and its DNA gyrase by the tricyclic 4-quinolone analogs ofloxacin and S-25930 stereoisomers. Antimicrob Agents Chemother. 1987 Nov; 31(11):1861-3. PMID: 2829717; PMCID: PMC175056.
  173. Wolfson JS, McHugh GL, Swartz MN, Ng EY, Hooper DC. Visualization of the mitochondrion-kinetoplast in viable Trypanosoma cruzi with rhodamine 123. J Parasitol. 1987 Aug; 73(4):866-9. PMID: 2442343.
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  174. Hooper DC, Wolfson JS, Ng EY, Swartz MN. Mechanisms of action of and resistance to ciprofloxacin. Am J Med. 1987 Apr 27; 82(4A):12-20. PMID: 3034057.
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  175. Hooper DC, Wolfson JS, Souza KS, Tung C, McHugh GL, Swartz MN. Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli. Antimicrob Agents Chemother. 1986 Apr; 29(4):639-44. PMID: 3010850; PMCID: PMC180458.
  176. Wolfson JS, McHugh GL, Hooper DC, Swartz MN. Knotting of DNA molecules isolated from deletion mutants of intact bacteriophage P4. Nucleic Acids Res. 1985 Sep 25; 13(18):6695-702. PMID: 3903657; PMCID: PMC321986.
  177. Weber DJ, Wolfson JS, Swartz MN, Hooper DC. Pasteurella multocida infections. Report of 34 cases and review of the literature. Medicine (Baltimore). 1984 May; 63(3):133-54. PMID: 6371440.
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  178. Hooper DC, Wolfson JS, McHugh GL, Swartz MD, Tung C, Swartz MN. Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Antimicrob Agents Chemother. 1984 May; 25(5):586-90. PMID: 6329090; PMCID: PMC185592.
  179. Wolfson JS, Hooper DC, Swartz MN, Swartz MD, McHugh GL. Novobiocin-induced elimination of F'lac and mini-F plasmids from Escherichia coli. J Bacteriol. 1983 Dec; 156(3):1165-70. PMID: 6315678; PMCID: PMC217963.
  180. Hooper DC, Bayer AS, Karchmer AW, Theofilopoulos AN, Swartz MN. Circulating immune complexes in prosthetic valve endocarditis. Arch Intern Med. 1983 Nov; 143(11):2081-4. PMID: 6639228.
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  181. Wolfson JS, Hooper DC, Swartz MN, Swartz MD, McHugh GL. Rapid method for screening large numbers of Escherichia coli colonies for production of plasmid-mediated beta-lactamases. Antimicrob Agents Chemother. 1983 Feb; 23(2):308-12. PMID: 6340605; PMCID: PMC186042.
  182. Hooper DC, Wolfson JS, McHugh GL, Winters MB, Swartz MN. Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth. Antimicrob Agents Chemother. 1982 Oct; 22(4):662-71. PMID: 6295263; PMCID: PMC183811.
  183. Wolfson JS, Hooper DC, Swartz MN, McHugh GL. Antagonism of the B subunit of DNA gyrase eliminates plasmids pBR322 and pMG110 from Escherichia coli. J Bacteriol. 1982 Oct; 152(1):338-44. PMID: 6288663; PMCID: PMC221411.
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