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Christiane Dorothea Wrann, Ph.D., D.V.M.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AG064580 (WRANN, CHRISTIANE D.) Sep 1, 2019 - Aug 31, 2020
    NIH/NIA
    Dissecting the molecular mediators of the neuroprotective effects of exercise in Alzheimer's Disease
    Role: Principal Investigator
  2. R21AG062904 (WRANN, CHRISTIANE D.) May 1, 2019 - Feb 28, 2021
    NIH/NIA
    Exploring irisin as a novel target for Alzheimer's Disease
    Role: Principal Investigator
  3. R00NS087096 (WRANN, CHRISTIANE D.) Jun 1, 2014 - Dec 31, 2019
    NIH/NINDS
    Molecular mechanisms of exercise benefits in synapse plasticity and cognition
    Role: Principal Investigator
  4. K99NS087096 (WRANN, CHRISTIANE D.) Jun 1, 2014 - May 30, 2016
    NIH/NINDS
    Molecular mechanisms of exercise benefits in synapse plasticity and cognition
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Estell EG, Le PT, Vegting Y, Kim H, Wrann C, Bouxsein ML, Nagano K, Baron R, Spiegelman BM, Rosen CJ. Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo. Elife. 2020 08 11; 9. PMID: 32780016.
    Citations:    
  2. Ohtomo R, Kinoshita K, Ohtomo G, Takase H, Hamanaka G, Washida K, Islam MR, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K. Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion. Transl Stroke Res. 2020 06; 11(3):496-502. PMID: 31606888.
    Citations:    
  3. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Irisin Mediates Effects on Bone and Fat via aV Integrin Receptors. Cell. 2019 Jul 11; 178(2):507-508. PMID: 31299203.
    Citations:    
  4. Young MF, Valaris S, Wrann CD. A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases. Prog Cardiovasc Dis. 2019 Mar - Apr; 62(2):172-178. PMID: 30844383.
    Citations:    
  5. Tari AR, Norevik CS, Scrimgeour NR, Kobro-Flatmoen A, Storm-Mathisen J, Bergersen LH, Wrann CD, Selbæk G, Kivipelto M, Moreira JBN, Wisløff U. Are the neuroprotective effects of exercise training systemically mediated? Prog Cardiovasc Dis. 2019 Mar - Apr; 62(2):94-101. PMID: 30802460.
    Citations:    
  6. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM. Irisin Mediates Effects on Bone and Fat via aV Integrin Receptors. Cell. 2018 12 13; 175(7):1756-1768.e17. PMID: 30550785.
    Citations:    Fields:    
  7. Islam MR, Young MF, Wrann CD. Neuroprotective potential of exercise preconditioning in stroke. Cond Med. 2017; 1(1):27-34. PMID: 30465042.
    Citations:    
  8. Jahn J, Spielau M, Brandsch C, Stangl GI, Delank KS, Bähr I, Berreis T, Wrann CD, Kielstein H. Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity (Silver Spring). 2015 Nov; 23(11):2233-41. PMID: 26390898.
    Citations: 9     Fields:    Translation:HumansCells
  9. Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015 Oct 06; 22(4):734-740. PMID: 26278051.
    Citations: 69     Fields:    Translation:HumansCells
  10. Wahlqvist ML, Krawetz SA, Rizzo NS, Dominguez-Bello MG, Szymanski LM, Barkin S, Yatkine A, Waterland RA, Mennella JA, Desai M, Ross MG, Krebs NF, Young BE, Wardle J, Wrann CD, Kral JG. Early-life influences on obesity: from preconception to adolescence. Ann N Y Acad Sci. 2015 Jul; 1347:1-28. PMID: 26037603.
    Citations: 8     Fields:    Translation:Humans
  11. Laue T, Wrann CD, Hoffmann-Castendiek B, Pietsch D, Hübner L, Kielstein H. Altered NK cell function in obese healthy humans. BMC Obes. 2015; 2:1. PMID: 26217516.
    Citations: 14     
  12. Wrann CD. FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain. Brain Plast. 2015; 1(1):55-61. PMID: 28480165.
    Citations: 7     
  13. White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15756-61. PMID: 25336758.
    Citations: 15     Fields:    Translation:AnimalsCells
  14. Spiegelman BM, Wrann C. Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383. Diabetes. 2014 Sep; 63(9):e17. PMID: 25146478.
    Citations:    Fields:    Translation:AnimalsCells
  15. Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014 Jun 05; 157(6):1279-1291. PMID: 24906147.
    Citations: 145     Fields:    Translation:AnimalsCells
  16. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19; 155(7):1624-38. PMID: 24360282.
    Citations: 244     Fields:    Translation:AnimalsCells
  17. Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL. Loss of Pgc-1a expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab. 2014 Jan 15; 306(2):E157-67. PMID: 24280126.
    Citations: 17     Fields:    Translation:AnimalsCells
  18. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise induces hippocampal BDNF through a PGC-1a/FNDC5 pathway. Cell Metab. 2013 Nov 05; 18(5):649-59. PMID: 24120943.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  19. Huebner L, Engeli S, Wrann CD, Goudeva L, Laue T, Kielstein H. Human NK cell subset functions are differentially affected by adipokines. PLoS One. 2013; 8(9):e75703. PMID: 24098717.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Wrann CD, Rosen ED. New insights into adipocyte-specific leptin gene expression. Adipocyte. 2012 Jul 01; 1(3):168-172. PMID: 23700528.
    Citations: 9     Fields:    
  21. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED. FOSL2 promotes leptin gene expression in human and mouse adipocytes. J Clin Invest. 2012 Mar; 122(3):1010-21. PMID: 22326952.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  22. Wrann CD, Laue T, Hübner L, Kuhlmann S, Jacobs R, Goudeva L, Nave H. Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions. Am J Physiol Endocrinol Metab. 2012 Jan 01; 302(1):E108-16. PMID: 21952038.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  23. Heger CD, Wrann CD, Collins RN. Phosphorylation provides a negative mode of regulation for the yeast Rab GTPase Sec4p. PLoS One. 2011; 6(9):e24332. PMID: 21931684.
    Citations: 7     Fields:    Translation:AnimalsCells
  24. Dahlke K, Wrann CD, Sommerfeld O, Sossdorf M, Recknagel P, Sachse S, Winter SW, Klos A, Stahl GL, Ma YX, Claus RA, Reinhart K, Bauer M, Riedemann NC. Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J Immunol. 2011 Mar 01; 186(5):3066-75. PMID: 21263075.
    Citations: 8     Fields:    Translation:Animals
  25. Lautenbach A, Wrann CD, Jacobs R, Müller G, Brabant G, Nave H. Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals. Obesity (Silver Spring). 2009 Oct; 17(10):1848-55. PMID: 19444229.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Wrann CD, Ehmer U, Lautenbach A, Kuhlmann S, Nave H. Obesity and NK cells affect the expression of the long form of the leptin receptor Ob-Rb in liver of F344 rats. Exp Toxicol Pathol. 2010 Jan; 62(1):1-8. PMID: 19186040.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Lautenbach A, Budde A, Wrann CD, Teichmann B, Vieten G, Karl T, Nave H. Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast cancer cells. Nutr Cancer. 2009; 61(4):484-91. PMID: 19838920.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  28. Agneskirchner JD, Hurschler C, Wrann CD, Lobenhoffer P. The effects of valgus medial opening wedge high tibial osteotomy on articular cartilage pressure of the knee: a biomechanical study. Arthroscopy. 2007 Aug; 23(8):852-61. PMID: 17681207.
    Citations: 42     Fields:    Translation:Humans
  29. Wrann CD, Winter SW, Barkhausen T, Hildebrand F, Krettek C, Riedemann NC. Distinct involvement of p38-, ERK1/2 and PKC signaling pathways in C5a-mediated priming of oxidative burst in phagocytic cells. Cell Immunol. 2007 Feb; 245(2):63-9. PMID: 17507002.
    Citations: 8     Fields:    Translation:HumansCells
  30. Wrann CD, Tabriz NA, Barkhausen T, Klos A, van Griensven M, Pape HC, Kendoff DO, Guo R, Ward PA, Krettek C, Riedemann NC. The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. J Immunol. 2007 May 01; 178(9):5940-8. PMID: 17442978.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.