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Christiane Dorothea Wrann, Ph.D., D.V.M.

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Mentoring
Available: 01/10/22, Expires: 03/01/24

Our lab focuses on the molecular mechanisms of the beneficial effects of exercise and metabolism on the brain, such as increased neurogenesis or synaptic plasticity. This exciting area of interdisciplinary research has a high translational potential. For our recent publications, see: Wrann et al. Cell Metabolism 2012, Jedrychowski, Wrann et al. Cell Metabolism 2015, Islam et al. Nature Metabolism 2021. A postdoctoral fellow is sought to drive research projects to identify novel factors and characterize their role in exercise and therapeutic potential using mouse models and molecular-based screenings methods. Those projects will involve cutting-edge technologies, including single-cell RNAseq, high-resolution mass spectrometry, or advanced imaging technologies.

Neuroprotection in Exercise [login at prompt]
Available: 02/01/23, Expires: 01/01/24

Preserving cognitive function is a major challenge in an increasingly aging population. Alzheimer's disease alone affects an estimated 5.5 million Americans today. Unfortunately, effective treatment options are still very limited. Interestingly, exercise is known to have positive effects on brain health. Exercise improves cognitive functions, stimulates adult hippocampal neurogenesis, and reduces neuroinflammation. Our research focuses on uncovering the molecular mechanisms linking exercise to neuroprotection in aging and neurodegeneration. The goal is to identify novel therapeutic targets and biomarkers for brain health in aging and neurodegenerative diseases, such as Alzheimer's disease. A special focus is secreted factors, which are desirable candidates for biomarkers or therapies. To accomplish our goals, we have established an interdisciplinary research program that integrates preclinical mouse models and human translational studies. In addition to traditional molecular and genetic approaches, we employ cutting-edge technologies, such as single-cell RNA-sequencing, high-resolution mass spectrometry, and advanced molecular imaging.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AG064580 (WRANN, CHRISTIANE D.) Sep 1, 2019 - Aug 31, 2021
    NIH
    Dissecting the molecular mediators of the neuroprotective effects of exercise in Alzheimer's Disease
    Role: Principal Investigator
  2. R21AG062904 (WRANN, CHRISTIANE D.) May 1, 2019 - Feb 28, 2021
    NIH
    Exploring irisin as a novel target for Alzheimer's Disease
    Role: Principal Investigator
  3. R00NS087096 (WRANN, CHRISTIANE D.) Jun 1, 2014 - Dec 31, 2021
    NIH
    Molecular mechanisms of exercise benefits in synapse plasticity and cognition
    Role: Principal Investigator
  4. K99NS087096 (WRANN, CHRISTIANE D.) Jun 1, 2014 - May 30, 2016
    NIH
    Molecular mechanisms of exercise benefits in synapse plasticity and cognition
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.