Harvard Catalyst Profiles

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Hua A Jenny Lu, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK096015 (LU, HUA A) Sep 20, 2013 - Jul 31, 2023
    NIH/NIDDK
    Novel role of AQP2 in cell migration and kidney tubular injury and repair
    Role: Principal Investigator
  2. R21DK092619 (LU, HUA A) Sep 17, 2012 - Aug 31, 2014
    NIH/NIDDK
    Role of the novel gene fam4b in phosphatidylserine synthesis in podocytes and mai
    Role: Principal Investigator
  3. R03DK084295 (LU, HUA A) Sep 1, 2009 - Feb 29, 2012
    NIH/NIDDK
    Using zebrafish to define a novel role for AQP2 in kidney tubulogenesis
    Role: Principal Investigator
  4. K08DK075940 (LU, HUA A) Jul 5, 2006 - Mar 30, 2012
    NIH/NIDDK
    Characterization of AQP2 interacting proteins and novel functions of AQP2
    Role: Principal Investigator
  5. F32DK065417 (LU, HUA A) Jul 1, 2003 - Jun 30, 2006
    NIH/NIDDK
    Characterization of Aquaporin 2 Interacting Proteins
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ham O, Jin W, Lei L, Huang HH, Tsuji K, Huang M, Roh J, Rosenzweig A, Lu HAJ. Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril. Sci Rep. 2018 Oct 31; 8(1):16087. PMID: 30382174.
    Citations:    Fields:    
  2. Lei L, Huang M, Su L, Xie D, Mamuya FA, Ham O, Tsuji K, Paunescu TG, Yang B, Lu HAJ. Manganese promotes intracellular accumulation of AQP2 via modulating F-actin polymerization and reduces urinary concentration in mice. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F306-F316. PMID: 29046300.
    Citations:    Fields:    
  3. Tsuji K, Suleiman H, Miner JH, Daley JM, Capen DE, Paunescu TG, Lu HAJ. Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM). Sci Rep. 2017 Sep 15; 7(1):11696. PMID: 28916834.
    Citations:    Fields:    
  4. Tsuji K, Paunescu TG, Suleiman H, Xie D, Mamuya FA, Miner JH, Lu HAJ. Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy. Sci Rep. 2017 08 16; 7(1):8321. PMID: 28814739.
    Citations: 1     Fields:    
  5. Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Paunescu TG, Brown D, Lu HAJ. Ezrin directly interacts with AQP2 and promotes its endocytosis. J Cell Sci. 2017 09 01; 130(17):2914-2925. PMID: 28754689.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  6. Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Paunescu TG, Lu HAJ. Deletion of ß1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis. Am J Physiol Renal Physiol. 2017 Oct 01; 313(4):F1026-F1037. PMID: 28701310.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Lu HA. Diabetes Insipidus. Adv Exp Med Biol. 2017; 969:213-225. PMID: 28258576.
    Citations:    Fields:    Translation:HumansAnimals
  8. Mamuya FA, Cano-Peñalver JL, Li W, Rodriguez Puyol D, Rodriguez Puyol M, Brown D, de Frutos S, Lu HA. ILK and cytoskeletal architecture: an important determinant of AQP2 recycling and subsequent entry into the exocytotic pathway. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1346-F1357. PMID: 27760768.
    Citations:    Fields:    Translation:AnimalsCells
  9. Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R. EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016 Oct; 27(10):3105-3116. PMID: 27694161.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Rice WL, Li W, Mamuya F, McKee M, Paunescu TG, Lu HA. Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture. PLoS One. 2015; 10(7):e0131719. PMID: 26147297; PMCID: PMC4493001.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D. High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration. Am J Physiol Cell Physiol. 2014 Oct 01; 307(7):C597-605. PMID: 24944200; PMCID: PMC4187055.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1783-95. PMID: 24133120; PMCID: PMC3882446.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Huang J, McKee M, Huang HD, Xiang A, Davidson AJ, Lu HA. A zebrafish model of conditional targeted podocyte ablation and regeneration. Kidney Int. 2013 Jun; 83(6):1193-200. PMID: 23466998.
    Citations: 20     Fields:    Translation:AnimalsCells
  14. Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D. Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013 Jan 01; 304(1):C38-48. PMID: 23015545; PMCID: PMC3543574.
    Citations: 21     Fields:    Translation:AnimalsCells
  15. Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA. Aquaporin 2 promotes cell migration and epithelial morphogenesis. J Am Soc Nephrol. 2012 Sep; 23(9):1506-17. PMID: 22859853; PMCID: PMC3431417.
    Citations: 20     Fields:    Translation:AnimalsCells
  16. Brown D, Bouley R, Paunescu TG, Breton S, Lu HA. New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33. PMID: 22460710; PMCID: PMC3362000.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  17. Rice WL, Zhang Y, Chen Y, Matsuzaki T, Brown D, Lu HA. Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells. PLoS One. 2012; 7(2):e32843. PMID: 22403603.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA. Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F309-18. PMID: 21511701; PMCID: PMC3154588.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D. Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration. J Am Soc Nephrol. 2011 Jan; 22(1):59-72. PMID: 21071524; PMCID: PMC3014035.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Lu HT, Guitton TG, Capo JT, Ring D. Elbow instability associated with bicolumnar fracture of the distal humerus: report of three cases. J Hand Surg Am. 2010 Jul; 35(7):1126-9. PMID: 20610058.
    Citations:    Fields:    Translation:Humans
  21. Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1575-86. PMID: 19776169; PMCID: PMC2801332.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D. A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1476-87. PMID: 18799651; PMCID: PMC2603565.
    Citations: 16     Fields:    Translation:AnimalsCells
  23. Brown D, Hasler U, Nunes P, Bouley R, Lu HA. Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):491-8. PMID: 18695390; PMCID: PMC3774073.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  24. Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D. Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008 Sep 26; 283(39):26643-61. PMID: 18664568; PMCID: PMC2546545.
    Citations: 24     Fields:    Translation:AnimalsCells
  25. Bouley R, Hasler U, Lu HA, Nunes P, Brown D. Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008 May; 28(3):266-78. PMID: 18519087; PMCID: PMC2494582.
    Citations: 27     Fields:    Translation:HumansCells
  26. Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D. The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F290-4. PMID: 18434387; PMCID: PMC2494506.
    Citations: 39     Fields:    Translation:AnimalsCells
  27. Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F130-8. PMID: 17959750.
    Citations: 41     Fields:    Translation:AnimalsCells
  28. Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28; 282(39):28721-32. PMID: 17636261.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.