Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileDaniel J. Finley, Ph.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Cell Biology
240 Longwood Ave
Boston MA 02115
Phone617/432-3492
Fax617/432-1144
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Identification of a Hub1 C-terminal Hydrolase from S. cerevisiae
Summer, 06/17/02 - 08/28/02

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL125710     (FINLEY, DANIEL J)May 15, 2015 - Mar 31, 2019
NIH/NHLBI
A novel program of ubiquitination in global remodeling of the erythroid proteome
Role: Principal Investigator

R21HL116210     (FINLEY, DANIEL J)May 15, 2012 - Apr 30, 2014
NIH/NHLBI
Ubiquitination in erythropoiesis and the pathophysiology of anemia
Role: Principal Investigator

R01GM095526     (FINLEY, DANIEL J)Jun 1, 2011 - May 31, 2015
NIH/NIGMS
Ubiquitin chain editing by the mammalian proteasome
Role: Principal Investigator

R21DK082906     (FINLEY, DANIEL J)Sep 30, 2008 - Jun 30, 2011
NIH/NIDDK
Studies of Usp14 and the Ubiquitin Stress Response
Role: Principal Investigator

R13DK067268     (FINLEY, DANIEL J)Jun 1, 2004 - May 31, 2005
NIH/NIDDK
Ubiquitination and Cellular Regulation
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Nguyen AT, Prado MA, Schmidt PJ, Sendamarai AK, Wilson-Grady JT, Min M, Campagna DR, Tian G, Shi Y, Dederer V, Kawan M, Kuehnle N, Paulo JA, Yao Y, Weiss MJ, Justice MJ, Gygi SP, Fleming MD, Finley D. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 04; 357(6350). PMID: 28774900.
    View in: PubMed
  2. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017 Jul 20; 67(2):322-333.e6. PMID: 28689658.
    View in: PubMed
  3. Quirós PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol. 2017 Jul 03; 216(7):2027-2045. PMID: 28566324.
    View in: PubMed
  4. Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R. Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress. Cell Res. 2017 May; 27(5):657-674. PMID: 28322253.
    View in: PubMed
  5. Li F, Tian G, Langager D, Sokolova V, Finley D, Park S. Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1548-1553. PMID: 28137839.
    View in: PubMed
  6. Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y. Structural basis for dynamic regulation of the human 26S proteasome. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):12991-12996. PMID: 27791164.
    View in: PubMed
  7. Rose CM, Isasa M, Ordureau A, Prado MA, Beausoleil SA, Jedrychowski MP, Finley DJ, Harper JW, Gygi SP. Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes. Cell Syst. 2016 Oct 26; 3(4):395-403.e4. PMID: 27667366.
    View in: PubMed
  8. Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites. Nature. 2016 Apr 21; 532(7599):398-401. PMID: 27074503; PMCID: PMC4844788 [Available on 10/13/16].
  9. Choi WH, de Poot SA, Lee JH, Kim JH, Han DH, Kim YK, Finley D, Lee MJ. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016 Mar 09; 7:10963. PMID: 26957043; PMCID: PMC4786872.
  10. Luan B, Huang X, Wu J, Mei Z, Wang Y, Xue X, Yan C, Wang J, Finley DJ, Shi Y, Wang F. Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2642-7. PMID: 26929360; PMCID: PMC4790998.
  11. Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ. Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome. Science. 2016 Feb 19; 351(6275). PMID: 26912900; PMCID: PMC4980823.
  12. Finley D, Chen X, Walters KJ. Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci. 2016 Jan; 41(1):77-93. PMID: 26643069; PMCID: PMC4706478 [Available on 01/01/17].
  13. Isasa M, Rose CM, Elsasser S, Navarrete-Perea J, Paulo JA, Finley DJ, Gygi SP. Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains. J Proteome Res. 2015 Dec 04; 14(12):5306-17. PMID: 26503604; PMCID: PMC4802358.
  14. Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife. 2015 Nov 02; 4:e10510. PMID: 26523394; PMCID: PMC4733041.
  15. Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science. 2015 Apr 10; 348(6231):1250834. PMID: 25859050; PMCID: PMC4450770.
  16. Silva GM, Finley D, Vogel C. K63 polyubiquitination is a new modulator of the oxidative stress response. Nat Struct Mol Biol. 2015 Feb; 22(2):116-23. PMID: 25622294; PMCID: PMC4318705.
  17. King RW, Finley D. Sculpting the proteome with small molecules. Nat Chem Biol. 2014 Nov; 10(11):870-4. PMID: 25325686; PMCID: PMC4639395.
  18. Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R. Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell. 2014 Jul 14; 26(1):106-20. PMID: 25026213; PMCID: PMC4166492.
  19. Liu YP, Tsai IC, Morleo M, Oh EC, Leitch CC, Massa F, Lee BH, Parker DS, Finley D, Zaghloul NA, Franco B, Katsanis N. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest. 2014 May; 124(5):2059-70. PMID: 24691443; PMCID: PMC4001542.
  20. Tar K, Dange T, Yang C, Yao Y, Bulteau AL, Salcedo EF, Braigen S, Bouillaud F, Finley D, Schmidt M. Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1. J Biol Chem. 2014 Apr 25; 289(17):12145-56. PMID: 24604417; PMCID: PMC4002118.
  21. Tar K, Dange T, Yang C, Yao Y, Bulteau AL, Fernandez Salcedo E, Braigen S, Bouillaud F, Finley D, Schmidt M. WITHDRAWN: Blm10-proteasomes antagonize mitochondrial fission through degradation of Dnm1. J Biol Chem. 2014 Jan 08. PMID: 24285543.
    View in: PubMed
  22. Hanna J, Waterman D, Isasa M, Elsasser S, Shi Y, Gygi S, Finley D. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem. 2014 Jan 17; 289(3):1876-85. PMID: 24297164; PMCID: PMC3894362.
  23. Schmidt M, Finley D. Regulation of proteasome activity in health and disease. Biochim Biophys Acta. 2014 Jan; 1843(1):13-25. PMID: 23994620; PMCID: PMC3858528.
  24. Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013 May 23; 497(7450):512-6. PMID: 23644457; PMCID: PMC3687086.
  25. Ehlinger A, Park S, Fahmy A, Lary JW, Cole JL, Finley D, Walters KJ. Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 binding. Structure. 2013 May 07; 21(5):753-65. PMID: 23562395; PMCID: PMC3670613.
  26. Lee BH, Finley D, King RW. A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14. Curr Protoc Chem Biol. 2012 Dec 01; 4(4):311-30. PMID: 23788557; PMCID: PMC3690187.
  27. Finley D, Ulrich HD, Sommer T, Kaiser P. The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics. 2012 Oct; 192(2):319-60. PMID: 23028185; PMCID: PMC3454868.
  28. Matouschek A, Finley D. Cell biology. An ancient portal to proteolysis. Science. 2012 Aug 17; 337(6096):813-4. PMID: 22904006; PMCID: PMC3581351.
  29. Hanna J, Waterman D, Boselli M, Finley D. Spg5 protein regulates the proteasome in quiescence. J Biol Chem. 2012 Oct 05; 287(41):34400-9. PMID: 22904326; PMCID: PMC3464545.
  30. Tian G, Finley D. Cell biology: Destruction deconstructed. Nature. 2012 Feb 08; 482(7384):170-1. PMID: 22318600.
    View in: PubMed
  31. Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol. 2012 Jan 29; 14(2):168-76. PMID: 22286100; PMCID: PMC3278798.
  32. Nag DK, Finley D. A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res. 2012 Apr; 165(1):103-6. PMID: 22306365.
    View in: PubMed
  33. Elsasser S, Shi Y, Finley D. Binding of ubiquitin conjugates to proteasomes as visualized with native gels. Methods Mol Biol. 2012; 832:403-22. PMID: 22350901; PMCID: PMC3593100.
  34. Chen PC, Bhattacharyya BJ, Hanna J, Minkel H, Wilson JA, Finley D, Miller RJ, Wilson SM. Ubiquitin homeostasis is critical for synaptic development and function. J Neurosci. 2011 Nov 30; 31(48):17505-13. PMID: 22131412; PMCID: PMC3253363.
  35. Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D. An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol. 2011 Oct 30; 18(11):1259-67. PMID: 22037170; PMCID: PMC3210322.
  36. Dange T, Smith D, Noy T, Rommel PC, Jurzitza L, Cordero RJ, Legendre A, Finley D, Goldberg AL, Schmidt M. Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem. 2011 Dec 16; 286(50):42830-9. PMID: 22025621; PMCID: PMC3234834.
  37. Finley D. Misfolded proteins driven to destruction by Hul5. Nat Cell Biol. 2011 Oct 09; 13(11):1290-2. PMID: 21983564.
    View in: PubMed
  38. Park S, Kim W, Tian G, Gygi SP, Finley D. Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response. J Biol Chem. 2011 Oct 21; 286(42):36652-66. PMID: 21878652; PMCID: PMC3196138.
  39. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 09; 467(7312):179-84. PMID: 20829789; PMCID: PMC2939003.
  40. Lee MJ, Lee BH, Hanna J, King RW, Finley D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics. 2011 May; 10(5):R110.003871. PMID: 20823120; PMCID: PMC3098602.
  41. Isasa M, Katz EJ, Kim W, Yugo V, González S, Kirkpatrick DS, Thomson TM, Finley D, Gygi SP, Crosas B. Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome. Mol Cell. 2010 Jun 11; 38(5):733-45. PMID: 20542005; PMCID: PMC3282119.
  42. Chen X, Lee BH, Finley D, Walters KJ. Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol Cell. 2010 May 14; 38(3):404-15. PMID: 20471946; PMCID: PMC2887722.
  43. Park S, Tian G, Roelofs J, Finley D. Assembly manual for the proteasome regulatory particle: the first draft. Biochem Soc Trans. 2010 Feb; 38(Pt 1):6-13. PMID: 20074027; PMCID: PMC3431156.
  44. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Liu Y, Louis WC, Mahn KB, Marsh W, McGary VT, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Nowak JA, Osmanov B, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Soderberg M, Sorel M, Spentzouris P, Spitz J, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED. Measurement of the ratio of the numu charged-current single-pion production to quasielastic scattering with a 0.8 GeV neutrino beam on mineral oil. Phys Rev Lett. 2009 Aug 21; 103(8):081801. PMID: 19792715.
    View in: PubMed
  45. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Grange J, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Liu Y, Louis WC, Mahn KB, Marsh W, Mauger C, McGary VT, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Mousseau J, Nelson RH, Nienaber P, Nowak JA, Osmanov B, Ouedraogo S, Patterson RB, Pavlovic Z, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Soderberg M, Sorel M, Spentzouris P, Spitz J, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water RG, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED. Search for muon neutrino and antineutrino disappearance in MiniBooNE. Phys Rev Lett. 2009 Aug 07; 103(6):061802. PMID: 19792551.
    View in: PubMed
  46. Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley D. Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature. 2009 Jun 11; 459(7248):861-5. PMID: 19412159; PMCID: PMC2727592.
  47. Park S, Roelofs J, Kim W, Robert J, Schmidt M, Gygi SP, Finley D. Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature. 2009 Jun 11; 459(7248):866-70. PMID: 19412160; PMCID: PMC2722381.
  48. Adamson P, Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Bishai M, Brice SJ, Brown BC, Bugel L, Cao J, Choudhary BC, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Gallagher HR, Garcia FG, Garvey GT, Green C, Green JA, Harris D, Hart TL, Hawker E, Hylen J, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kopp S, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Liu Y, Loiacono L, Louis WC, Marchionni A, Mahn KB, Marsh W, McGregor G, Messier MD, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson JK, Nelson RH, Nguyen VT, Nienaber P, Nowak JA, Ouedraogo S, Patterson RB, Pavlovic Z, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smart W, Smith D, Sodeberg M, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Vahle P, Van de Water R, Viren B, Wascko MO, White DH, Wilking MJ, Yang HJ, Yumiceva FX, Zeller GP, Zimmerman ED, Zwaska R. Measurement of numicro and nue events in an off-axis horn-focused neutrino beam. Phys Rev Lett. 2009 May 29; 102(21):211801. PMID: 19519094.
    View in: PubMed
  49. Zhang F, Wu Z, Zhang P, Tian G, Finley D, Shi Y. Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell. 2009 May 14; 34(4):485-96. PMID: 19481528.
    View in: PubMed
  50. Zhang F, Hu M, Tian G, Zhang P, Finley D, Jeffrey PD, Shi Y. Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell. 2009 May 14; 34(4):473-84. PMID: 19481527; PMCID: PMC3268689.
  51. Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J, Hochstrasser M, Finley D, Peng J. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell. 2009 Apr 03; 137(1):133-45. PMID: 19345192; PMCID: PMC2668214.
  52. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Liu Y, Louis WC, Mahn KB, Marsh W, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nguyen VT, Nienaber P, Nowak JA, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sodeberg M, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED. Unexplained excess of electronlike events from a 1-GeV neutrino beam. Phys Rev Lett. 2009 Mar 13; 102(10):101802. PMID: 19392103.
    View in: PubMed
  53. Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem. 2009; 78:477-513. PMID: 19489727; PMCID: PMC3431160.
  54. Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 2008 May 22; 453(7194):481-8. PMID: 18497817; PMCID: PMC2839886.
  55. Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature. 2008 May 22; 453(7194):548-52. PMID: 18497827; PMCID: PMC2825158.
  56. Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem. 2008 Jan 30; 9:4. PMID: 18234089; PMCID: PMC2267792.
  57. Aguilar-Arevalo AA, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Link JM, Liu Y, Liu Y, Louis WC, Mahn KB, Marsh W, Martin PS, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED. Measurement of muon neutrino quasielastic scattering on carbon. Phys Rev Lett. 2008 Jan 25; 100(3):032301. PMID: 18232974.
    View in: PubMed
  58. Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D. Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nat Struct Mol Biol. 2007 Dec; 14(12):1180-8. PMID: 18026118.
    View in: PubMed
  59. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007 Sep 07; 27(5):731-44. PMID: 17803938; PMCID: PMC2083707.
  60. Aguilar-Arevalo AA, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Link JM, Liu Y, Liu Y, Louis WC, Mahn KB, Marsh W, Martin PS, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED. Search for electron neutrino appearance at the Delta m2 approximately 1 eV2 scale. Phys Rev Lett. 2007 Jun 08; 98(23):231801. PMID: 17677898.
    View in: PubMed
  61. Hanna J, Meides A, Zhang DP, Finley D. A ubiquitin stress response induces altered proteasome composition. Cell. 2007 May 18; 129(4):747-59. PMID: 17512408.
    View in: PubMed
  62. Hanna J, Finley D. A proteasome for all occasions. FEBS Lett. 2007 Jun 19; 581(15):2854-61. PMID: 17418826; PMCID: PMC1965587.
  63. Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 2006 Dec 29; 127(7):1401-13. PMID: 17190603.
    View in: PubMed
  64. Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 2006 Oct 06; 127(1):99-111. PMID: 17018280.
    View in: PubMed
  65. Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol. 2006 Jul; 8(7):700-10. PMID: 16799550.
    View in: PubMed
  66. Elsasser S, Finley D. Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol. 2005 Aug; 7(8):742-9. PMID: 16056265.
    View in: PubMed
  67. Schmidt M, Hanna J, Elsasser S, Finley D. Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem. 2005 Aug; 386(8):725-37. PMID: 16201867.
    View in: PubMed
  68. Shang F, Deng G, Liu Q, Guo W, Haas AL, Crosas B, Finley D, Taylor A. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27; 280(21):20365-74. PMID: 15790562; PMCID: PMC1382285.
  69. Schmidt M, Haas W, Crosas B, Santamaria PG, Gygi SP, Walz T, Finley D. The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol. 2005 Apr; 12(4):294-303. PMID: 15778719.
    View in: PubMed
  70. Leggett DS, Glickman MH, Finley D. Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol Biol. 2005; 301:57-70. PMID: 15917626.
    View in: PubMed
  71. Elsasser S, Schmidt M, Finley D. Characterization of the proteasome using native gel electrophoresis. Methods Enzymol. 2005; 398:353-63. PMID: 16275342.
    View in: PubMed
  72. Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr Biol. 2004 Dec 29; 14(24):2283-8. PMID: 15620657.
    View in: PubMed
  73. Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D. Varshavsky's contributions. Science. 2004 Nov 19; 306(5700):1290-2. PMID: 15550643.
    View in: PubMed
  74. Newman RM, Mobascher A, Mangold U, Koike C, Diah S, Schmidt M, Finley D, Zetter BR. Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem. 2004 Oct 01; 279(40):41504-11. PMID: 15277517.
    View in: PubMed
  75. Elsasser S, Chandler-Militello D, Müller B, Hanna J, Finley D. Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem. 2004 Jun 25; 279(26):26817-22. PMID: 15117949.
    View in: PubMed
  76. Janse DM, Crosas B, Finley D, Church GM. Localization to the proteasome is sufficient for degradation. J Biol Chem. 2004 May 14; 279(20):21415-20. PMID: 15039430.
    View in: PubMed
  77. Finley D, Ciechanover A, Varshavsky A. Ubiquitin as a central cellular regulator. Cell. 2004 Jan 23; 116(2 Suppl):S29-32, 2 p following S32. PMID: 15055578.
    View in: PubMed
  78. Hanna J, Leggett DS, Finley D. Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol Cell Biol. 2003 Dec; 23(24):9251-61. PMID: 14645527; PMCID: PMC309641.
  79. Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP. A proteomics approach to understanding protein ubiquitination. Nat Biotechnol. 2003 Aug; 21(8):921-6. PMID: 12872131.
    View in: PubMed
  80. Bajorek M, Finley D, Glickman MH. Proteasome disassembly and downregulation is correlated with viability during stationary phase. Curr Biol. 2003 Jul 01; 13(13):1140-4. PMID: 12842014.
    View in: PubMed
  81. Santamaria PG, Finley D, Ballesta JP, Remacha M. Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem. 2003 Feb 28; 278(9):6687-95. PMID: 12486135.
    View in: PubMed
  82. Elsasser S, Gali RR, Schwickart M, Larsen CN, Leggett DS, Müller B, Feng MT, Tübing F, Dittmar GA, Finley D. Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol. 2002 Sep; 4(9):725-30. PMID: 12198498.
    View in: PubMed
  83. Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT, Walz T, Ploegh H, Finley D. Multiple associated proteins regulate proteasome structure and function. Mol Cell. 2002 Sep; 10(3):495-507. PMID: 12408819.
    View in: PubMed
  84. Finley D. Ubiquitin chained and crosslinked. Nat Cell Biol. 2002 May; 4(5):E121-3. PMID: 11988752.
    View in: PubMed
  85. Dittmar GA, Wilkinson CR, Jedrzejewski PT, Finley D. Role of a ubiquitin-like modification in polarized morphogenesis. Science. 2002 Mar 29; 295(5564):2442-6. PMID: 11923536.
    View in: PubMed
  86. Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, Sommer T. Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol. 2002 Feb; 4(2):134-9. PMID: 11813000.
    View in: PubMed
  87. Finley D. Signal transduction. An alternative to destruction. Nature. 2001 Jul 19; 412(6844):283, 285-6. PMID: 11460144.
    View in: PubMed
  88. Köhler A, Cascio P, Leggett DS, Woo KM, Goldberg AL, Finley D. The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell. 2001 Jun; 7(6):1143-52. PMID: 11430818.
    View in: PubMed
  89. Köhler A, Bajorek M, Groll M, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D. The substrate translocation channel of the proteasome. Biochimie. 2001 Mar-Apr; 83(3-4):325-32. PMID: 11295493.
    View in: PubMed
  90. Groll M, Bajorek M, Köhler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D. A gated channel into the proteasome core particle. Nat Struct Biol. 2000 Nov; 7(11):1062-7. PMID: 11062564.
    View in: PubMed
  91. Spence J, Gali RR, Dittmar G, Sherman F, Karin M, Finley D. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell. 2000 Jul 07; 102(1):67-76. PMID: 10929714.
    View in: PubMed
  92. Schmidt M, Lupas AN, Finley D. Structure and mechanism of ATP-dependent proteases. Curr Opin Chem Biol. 1999 Oct; 3(5):584-91. PMID: 10508673.
    View in: PubMed
  93. Horwich AL, Weber-Ban EU, Finley D. Chaperone rings in protein folding and degradation. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11033-40. PMID: 10500119; PMCID: PMC34237.
  94. Braun BC, Glickman M, Kraft R, Dahlmann B, Kloetzel PM, Finley D, Schmidt M. The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol. 1999 Aug; 1(4):221-6. PMID: 10559920.
    View in: PubMed
  95. Glickman MH, Rubin DM, Fu H, Larsen CN, Coux O, Wefes I, Pfeifer G, Cjeka Z, Vierstra R, Baumeister W, Fried V, Finley D. Functional analysis of the proteasome regulatory particle. Mol Biol Rep. 1999 Apr; 26(1-2):21-8. PMID: 10363642.
    View in: PubMed
  96. Fu H, Girod PA, Doelling JH, van Nocker S, Hochstrasser M, Finley D, Vierstra RD. Structure and functional analysis of the 26S proteasome subunits from plants. Mol Biol Rep. 1999 Apr; 26(1-2):137-46. PMID: 10363660.
    View in: PubMed
  97. Glickman MH, Rubin DM, Coux O, Wefes I, Pfeifer G, Cjeka Z, Baumeister W, Fried VA, Finley D. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell. 1998 Sep 04; 94(5):615-23. PMID: 9741626.
    View in: PubMed
  98. Rubin DM, Glickman MH, Larsen CN, Dhruvakumar S, Finley D. Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J. 1998 Sep 01; 17(17):4909-19. PMID: 9724628; PMCID: PMC1170820.
  99. Glickman MH, Rubin DM, Fried VA, Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol. 1998 Jun; 18(6):3149-62. PMID: 9584156; PMCID: PMC108897.
  100. Sears C, Olesen J, Rubin D, Finley D, Maniatis T. NF-kappa B p105 processing via the ubiquitin-proteasome pathway. J Biol Chem. 1998 Jan 16; 273(3):1409-19. PMID: 9430676.
    View in: PubMed
  101. Larsen CN, Finley D. Protein translocation channels in the proteasome and other proteases. Cell. 1997 Nov 14; 91(4):431-4. PMID: 9390550.
    View in: PubMed
  102. Rubin DM, van Nocker S, Glickman M, Coux O, Wefes I, Sadis S, Fu H, Goldberg A, Vierstra R, Finley D. ATPase and ubiquitin-binding proteins of the yeast proteasome. Mol Biol Rep. 1997 Mar; 24(1-2):17-26. PMID: 9228276.
    View in: PubMed
  103. Yaglom JA, Goldberg AL, Finley D, Sherman MY. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol. 1996 Jul; 16(7):3679-84. PMID: 8668184; PMCID: PMC231363.
  104. Rubin DM, Coux O, Wefes I, Hengartner C, Young RA, Goldberg AL, Finley D. Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome. Nature. 1996 Feb 15; 379(6566):655-7. PMID: 8628401.
    View in: PubMed
  105. Wefes I, Kaiser P, Schneider R, Pickart CM, Finley D. Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme. Gene. 1995 Oct 03; 163(2):321-2. PMID: 7590289.
    View in: PubMed
  106. Sadis S, Atienza C, Finley D. Synthetic signals for ubiquitin-dependent proteolysis. Mol Cell Biol. 1995 Aug; 15(8):4086-94. PMID: 7623804; PMCID: PMC230647.
  107. Rubin DM, Finley D. Proteolysis. The proteasome: a protein-degrading organelle? Curr Biol. 1995 Aug 01; 5(8):854-8. PMID: 7583140.
    View in: PubMed
  108. Wefes I, Mastrandrea LD, Haldeman M, Koury ST, Tamburlin J, Pickart CM, Finley D. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4982-6. PMID: 7761435; PMCID: PMC41831.
  109. Spence J, Sadis S, Haas AL, Finley D. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol Cell Biol. 1995 Mar; 15(3):1265-73. PMID: 7862120; PMCID: PMC230349.
  110. Yaglom J, Linskens MH, Sadis S, Rubin DM, Futcher B, Finley D. p34Cdc28-mediated control of Cln3 cyclin degradation. Mol Cell Biol. 1995 Feb; 15(2):731-41. PMID: 7823941; PMCID: PMC231941.
  111. Finley D, Sadis S, Monia BP, Boucher P, Ecker DJ, Crooke ST, Chau V. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol. 1994 Aug; 14(8):5501-9. PMID: 8035826; PMCID: PMC359070.
  112. Driscoll J, Brown MG, Finley D, Monaco JJ. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature. 1993 Sep 16; 365(6443):262-4. PMID: 8371781.
    View in: PubMed
  113. Driscoll J, Finley D. A controlled breakdown: antigen processing and the turnover of viral proteins. Cell. 1992 Mar 06; 68(5):823-5. PMID: 1312390.
    View in: PubMed
  114. Park EC, Finley D, Szostak JW. A strategy for the generation of conditional mutations by protein destabilization. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1249-52. PMID: 1311090; PMCID: PMC48426.
  115. Finley D, Chau V. Ubiquitination. Annu Rev Cell Biol. 1991; 7:25-69. PMID: 1667082.
    View in: PubMed
  116. Finley D, Bartel B, Varshavsky A. The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Nature. 1989 Mar 30; 338(6214):394-401. PMID: 2538753.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Finley's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_