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Harald Werner Jueppner, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DK075856 (JUEPPNER, HARALD W.) Aug 10, 2006 - May 31, 2008
    NIH/NIDDK
    IDENTIFICATION OF NOVEL PHOSPHATE REGULATORS
    Role: Principal Investigator
  2. R01DK050708 (JUEPPNER, HARALD W.) May 1, 1996 - Jan 31, 2005
    NIH/NIDDK
    CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    Role: Principal Investigator
  3. R01DK046718 (JUEPPNER, HARALD W.) May 1, 1993 - Jun 30, 2021
    NIH/NIDDK
    Molecular definition of pseudohypoparathyroidism
    Role: Principal Investigator
  4. R56DK046718 (JUEPPNER, HARALD W.) May 1, 1993 - Mar 31, 2013
    NIH/NIDDK
    Molecular Definition of Pseudohypoparathyroidism
    Role: Principal Investigator
  5. R37DK046718 (JUEPPNER, HARALD W.) May 1, 1993 - Apr 30, 2012
    NIH/NIDDK
    Molecular Definition of Pseudohypoparathyroidism
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Isakova T, Xie H, Barchi-Chung A, Vargas G, Sowden N, Houston J, Wahl P, Lundquist A, Epstein M, Smith K, Contreras G, Ortega L, Lenz O, Briones P, Egbert P, Ikizler TA, Jueppner H, Wolf M. Fibroblast growth factor 23 in patients undergoing peritoneal dialysis. Clin J Am Soc Nephrol. 2011 Nov; 6(11):2688-95. PMID: 21903990; PMCID: PMC3206004.
  2. Hoffman WH, Jueppner HW, Deyoung BR, O'dorisio MS, Given KS. Elevated fibroblast growth factor-23 in hypophosphatemic linear nevus sebaceous syndrome. Am J Med Genet A. 2005 Apr 30; 134(3):233-6. PMID: 15742370.
    View in: PubMed
  3. Gensure RC, Gardella TJ, Jüppner H. Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun. 2005 Mar 18; 328(3):666-78. PMID: 15694400.
    View in: PubMed
  4. Bastepe M, Jüppner H. GNAS locus and pseudohypoparathyroidism. Horm Res. 2005; 63(2):65-74. PMID: 15711092.
    View in: PubMed
  5. Gensure R, Jüppner H. Parathyroid hormone without parathyroid glands. Endocrinology. 2005 Feb; 146(2):544-6. PMID: 15649970.
    View in: PubMed
  6. Mahmud FH, Linglart A, Bastepe M, Jüppner H, Lteif AN. Molecular diagnosis of pseudohypoparathyroidism type Ib in a family with presumed paroxysmal dyskinesia. Pediatrics. 2005 Feb; 115(2):e242-4. PMID: 15629959.
    View in: PubMed
  7. Divieti P, Geller AI, Suliman G, Jüppner H, Bringhurst FR. Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology. 2005 Apr; 146(4):1863-70. PMID: 15625242.
    View in: PubMed
  8. Bastepe M, Fröhlich LF, Linglart A, Abu-Zahra HS, Tojo K, Ward LM, Jüppner H. Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib. Nat Genet. 2005 Jan; 37(1):25-7. PMID: 15592469.
    View in: PubMed
  9. Laspa E, Bastepe M, Jüppner H, Tsatsoulis A. Phenotypic and molecular genetic aspects of pseudohypoparathyroidism type Ib in a Greek kindred: evidence for enhanced uric acid excretion due to parathyroid hormone resistance. J Clin Endocrinol Metab. 2004 Dec; 89(12):5942-7. PMID: 15579741.
    View in: PubMed
  10. Fröhlich LF, Gensure RC, Schipani E, Jüppner H, Bastepe M. Haplotype frequencies and linkage disequilibrium analysis of four frequent polymorphisms at the PTH/PTH-related peptide receptor gene locus. Mol Cell Probes. 2004 Oct; 18(5):353-7. PMID: 15294324.
    View in: PubMed
  11. Bastepe M, Weinstein LS, Ogata N, Kawaguchi H, Jüppner H, Kronenberg HM, Chung UI. Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14794-9. PMID: 15459318; PMCID: PMC522030.
  12. Papasani MR, Gensure RC, Yan YL, Gunes Y, Postlethwait JH, Ponugoti B, John MR, Jüppner H, Rubin DA. Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39. Endocrinology. 2004 Nov; 145(11):5294-304. PMID: 15297442.
    View in: PubMed
  13. Bastepe M, Raas-Rothschild A, Silver J, Weissman I, Wientroub S, Jüppner H, Gillis D. A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutation. J Clin Endocrinol Metab. 2004 Jul; 89(7):3595-600. PMID: 15240651.
    View in: PubMed
  14. Salusky IB, Jüppner H. New PTH assays and renal osteodystrophy. Pediatr Nephrol. 2004 Jul; 19(7):709-13. PMID: 15173936.
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  15. Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Jüppner H, Jonsson KB. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology. 2004 Jul; 145(7):3087-94. PMID: 14988389.
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  16. Salusky IB, Kuizon BG, Jüppner H. Special aspects of renal osteodystrophy in children. Semin Nephrol. 2004 Jan; 24(1):69-77. PMID: 14730512.
    View in: PubMed
  17. Gensure RC, Ponugoti B, Gunes Y, Papasani MR, Lanske B, Bastepe M, Rubin DA, Jüppner H. Identification and characterization of two parathyroid hormone-like molecules in zebrafish. Endocrinology. 2004 Apr; 145(4):1634-9. PMID: 14684608.
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  18. Larsson T, Nisbeth U, Ljunggren O, Jüppner H, Jonsson KB. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int. 2003 Dec; 64(6):2272-9. PMID: 14633152.
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  19. Bastepe M, Fröhlich LF, Hendy GN, Indridason OS, Josse RG, Koshiyama H, Körkkö J, Nakamoto JM, Rosenbloom AL, Slyper AH, Sugimoto T, Tsatsoulis A, Crawford JD, Jüppner H. Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. J Clin Invest. 2003 Oct; 112(8):1255-63. PMID: 14561710; PMCID: PMC213493.
  20. Nelson AE, Bligh RC, Mirams M, Gill A, Au A, Clarkson A, Jüppner H, Ruff S, Stalley P, Scolyer RA, Robinson BG, Mason RS, Bligh PC. Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia. J Clin Endocrinol Metab. 2003 Sep; 88(9):4088-94. PMID: 12970268.
    View in: PubMed
  21. Bastepe M, Jüppner H. Editorial: Pseudohypoparathyroidism and mechanisms of resistance toward multiple hormones: molecular evidence to clinical presentation. J Clin Endocrinol Metab. 2003 Sep; 88(9):4055-8. PMID: 12970261.
    View in: PubMed
  22. Salusky IB, Goodman WG, Kuizon BD, Lavigne JR, Zahranik RJ, Gales B, Wang HJ, Elashoff RM, Jüppner H. Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis. Kidney Int. 2003 May; 63(5):1801-8. PMID: 12675856.
    View in: PubMed
  23. Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, Yamamoto T, Hampson G, Koshiyama H, Ljunggren O, Oba K, Yang IM, Miyauchi A, Econs MJ, Lavigne J, Jüppner H. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med. 2003 Apr 24; 348(17):1656-63. PMID: 12711740.
    View in: PubMed
  24. Larsson T, Zahradnik R, Lavigne J, Ljunggren O, Jüppner H, Jonsson KB. Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia. Eur J Endocrinol. 2003 Feb; 148(2):269-76. PMID: 12590648.
    View in: PubMed
  25. Goodman WG, Jüppner H, Salusky IB, Sherrard DJ. Parathyroid hormone (PTH), PTH-derived peptides, and new PTH assays in renal osteodystrophy. Kidney Int. 2003 Jan; 63(1):1-11. PMID: 12472763.
    View in: PubMed
  26. Jüppner H, Potts JT. Immunoassays for the detection of parathyroid hormone. J Bone Miner Res. 2002 Nov; 17 Suppl 2:N81-6. PMID: 12412782.
    View in: PubMed
  27. Goodman WG, Salusky IB, Jüppner H. New lessons from old assays: parathyroid hormone (PTH), its receptors, and the potential biological relevance of PTH fragments. Nephrol Dial Transplant. 2002 Oct; 17(10):1731-6. PMID: 12270977.
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  28. Bastepe M, Gunes Y, Perez-Villamil B, Hunzelman J, Weinstein LS, Jüppner H. Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit. Mol Endocrinol. 2002 Aug; 16(8):1912-9. PMID: 12145344.
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  29. John MR, Arai M, Rubin DA, Jonsson KB, Jüppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002 Mar; 143(3):1047-57. PMID: 11861531.
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  30. Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, Jüppner H, Andrulis IL, Wunder JS, Alman BA. A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat Genet. 2002 Mar; 30(3):306-10. PMID: 11850620.
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  31. Jüppner H. The genetic basis of progressive osseous heteroplasia. N Engl J Med. 2002 Jan 10; 346(2):128-30. PMID: 11784882.
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  32. Divieti P, John MR, Jüppner H, Bringhurst FR. Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor. Endocrinology. 2002 Jan; 143(1):171-6. PMID: 11751606.
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  33. Soegiarto DW, Kiachopoulos S, Schipani E, Jüppner H, Erben RG, Lanske B. Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene. Endocrinology. 2001 Dec; 142(12):5303-10. PMID: 11713230.
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  34. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16; 107(4):513-23. PMID: 11719191.
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  35. Gensure RC, Carter PH, Petroni BD, Jüppner H, Gardella TJ. Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis. J Biol Chem. 2001 Nov 16; 276(46):42692-9. PMID: 11553625.
    View in: PubMed
  36. Gardella TJ, Jüppner H. Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab. 2001 Jul; 12(5):210-7. PMID: 11397646.
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  37. Bastepe M, Pincus JE, Sugimoto T, Tojo K, Kanatani M, Azuma Y, Kruse K, Rosenbloom AL, Koshiyama H, Jüppner H. Positional dissociation between the genetic mutation responsible for pseudohypoparathyroidism type Ib and the associated methylation defect at exon A/B: evidence for a long-range regulatory element within the imprinted GNAS1 locus. Hum Mol Genet. 2001 Jun 01; 10(12):1231-41. PMID: 11406605.
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  38. Jonsson KB, Mannstadt M, Miyauchi A, Yang IM, Stein G, Jüppner H. Extracts from tumors causing oncogenic osteomalacia inhibit phosphate uptake in opossum kidney cells. J Endocrinol. 2001 Jun; 169(3):613-20. PMID: 11375132.
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  39. Gensure RC, Gardella TJ, Jüppner H. Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking. J Biol Chem. 2001 Aug 03; 276(31):28650-8. PMID: 11356832.
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  40. Bastepe M, Lane AH, Jüppner H. Paternal uniparental isodisomy of chromosome 20q--and the resulting changes in GNAS1 methylation--as a plausible cause of pseudohypoparathyroidism. Am J Hum Genet. 2001 May; 68(5):1283-9. PMID: 11294659; PMCID: PMC1226109.
  41. Jonsson KB, John MR, Gensure RC, Gardella TJ, Jüppner H. Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist. Endocrinology. 2001 Feb; 142(2):704-9. PMID: 11159842.
    View in: PubMed
  42. White KE, Jonsson KB, Carn G, Hampson G, Spector TD, Mannstadt M, Lorenz-Depiereux B, Miyauchi A, Yang IM, Ljunggren O, Meitinger T, Strom TM, Jüppner H, Econs MJ. The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. J Clin Endocrinol Metab. 2001 Feb; 86(2):497-500. PMID: 11157998.
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  43. Divieti P, Inomata N, Chapin K, Singh R, Jüppner H, Bringhurst FR. Receptors for the carboxyl-terminal region of pth(1-84) are highly expressed in osteocytic cells. Endocrinology. 2001 Feb; 142(2):916-25. PMID: 11159865.
    View in: PubMed
  44. Gardella TJ, Jüppner H. Interaction of PTH and PTHrP with their receptors. Rev Endocr Metab Disord. 2000 Nov; 1(4):317-29. PMID: 11706746.
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  45. Bastepe M, Jüppner H. Pseudohypoparathyroidism. New insights into an old disease. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):569-89. PMID: 11033761.
    View in: PubMed
  46. Hoare SR, Rubin DA, Jüppner H, Usdin TB. Evaluating the ligand specificity of zebrafish parathyroid hormone (PTH) receptors: comparison of PTH, PTH-related protein, and tuberoinfundibular peptide of 39 residues. Endocrinology. 2000 Sep; 141(9):3080-6. PMID: 10965877.
    View in: PubMed
  47. Bastepe M, Jüppner H. Identification and characterization of two new, highly polymorphic loci adjacent to GNAS1 on chromosome 20q13.3. Mol Cell Probes. 2000 Aug; 14(4):261-4. PMID: 10970731.
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  48. Jüppner H. Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development. Pediatr Nephrol. 2000 Jul; 14(7):606-11. PMID: 10912527.
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  49. Sanchez CP, Kuizon BD, Abdella PA, Jüppner H, Salusky IB, Goodman WG. Impaired growth, delayed ossification, and reduced osteoclastic activity in the growth plate of calcium-supplemented rats with renal failure. Endocrinology. 2000 Apr; 141(4):1536-44. PMID: 10746661.
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  50. Bastepe M, Pincus JE, Jüppner H. Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13. Mol Cell Probes. 1999 Dec; 13(6):449-51. PMID: 10657150.
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  51. John MR, Goodman WG, Gao P, Cantor TL, Salusky IB, Jüppner H. A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab. 1999 Nov; 84(11):4287-90. PMID: 10566687.
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  52. Mannstadt M, Jüppner H, Gardella TJ. Receptors for PTH and PTHrP: their biological importance and functional properties. Am J Physiol. 1999 11; 277(5):F665-75. PMID: 10564229.
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  53. Carter PH, Jüppner H, Gardella TJ. Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents. Endocrinology. 1999 Nov; 140(11):4972-81. PMID: 10537121.
    View in: PubMed
  54. Rubin DA, Jüppner H. Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide. J Biol Chem. 1999 Oct 01; 274(40):28185-90. PMID: 10497171.
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  55. Schipani E, Langman C, Hunzelman J, Le Merrer M, Loke KY, Dillon MJ, Silve C, Jüppner H. A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia. J Clin Endocrinol Metab. 1999 Sep; 84(9):3052-7. PMID: 10487664.
    View in: PubMed
  56. Rubin DA, Hellman P, Zon LI, Lobb CJ, Bergwitz C, Jüppner H. A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999 Aug 13; 274(33):23035-42. PMID: 10438471.
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  57. Jüppner H. Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance. Bone. 1999 Jul; 25(1):87-90. PMID: 10423028.
    View in: PubMed
  58. Sanchez CP, Salusky IB, Kuizon BD, Abdella P, Jüppner H, Goodman WG. Growth of long bones in renal failure: roles of hyperparathyroidism, growth hormone and calcitriol. Kidney Int. 1998 Dec; 54(6):1879-87. PMID: 9853253.
    View in: PubMed
  59. Jüppner H, Schipani E, Bastepe M, Cole DE, Lawson ML, Mannstadt M, Hendy GN, Plotkin H, Koshiyama H, Koh T, Crawford JD, Olsen BR, Vikkula M. The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11798-803. PMID: 9751745; PMCID: PMC21720.
  60. Goodman WG, Veldhuis JD, Belin TR, Van Herle AJ, Juppner H, Salusky IB. Calcium-sensing by parathyroid glands in secondary hyperparathyroidism. J Clin Endocrinol Metab. 1998 Aug; 83(8):2765-72. PMID: 9709944.
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  61. Mannstadt M, Luck MD, Gardella TJ, Jüppner H. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. J Biol Chem. 1998 Jul 03; 273(27):16890-6. PMID: 9642250.
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  62. Bergwitz C, Klein P, Kohno H, Forman SA, Lee K, Rubin D, Jüppner H. Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin). Endocrinology. 1998 Feb; 139(2):723-32. PMID: 9449646.
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  63. Kuizon BD, Goodman WG, Jüppner H, Boechat I, Nelson P, Gales B, Salusky IB. Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD. Kidney Int. 1998 Jan; 53(1):205-11. PMID: 9453020.
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  64. Kronenberg HM, Lanske B, Kovacs CS, Chung UI, Lee K, Segre GV, Schipani E, Jüppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res. 1998; 53:283-301; discussion 301-3. PMID: 9769712.
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  65. Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Jüppner H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13689-94. PMID: 9391087; PMCID: PMC28367.
  66. Bergwitz C, Jusseaume SA, Luck MD, Jüppner H, Gardella TJ. Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide. J Biol Chem. 1997 Nov 14; 272(46):28861-8. PMID: 9360953.
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  67. Suva LJ, Flannery MS, Caulfield MP, Findlay DM, Jüppner H, Goldring SR, Rosenblatt M, Chorev M. Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor. J Pharmacol Exp Ther. 1997 Nov; 283(2):876-84. PMID: 9353409.
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  68. Potts JT, Gardella TJ, Jüppner H, Kronenberg HM. Structure based design of parathyroid hormone analogs. J Endocrinol. 1997 Sep; 154 Suppl:S15-21. PMID: 9379133.
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  69. Li YC, Bergwitz C, Jüppner H, Demay MB. Cloning and characterization of the vitamin D receptor from Xenopus laevis. Endocrinology. 1997 Jun; 138(6):2347-53. PMID: 9165021.
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  70. Schipani E, Jensen GS, Pincus J, Nissenson RA, Gardella TJ, Jüppner H. Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. Mol Endocrinol. 1997 Jun; 11(7):851-8. PMID: 9178745.
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  71. Goodman WG, Veldhuis JD, Belin TR, Juppner H, Salusky IB. Suppressive effect of calcium on parathyroid hormone release in adynamic renal osteodystrophy and secondary hyperparathyroidism. Kidney Int. 1997 May; 51(5):1590-5. PMID: 9150477.
    View in: PubMed
  72. Potts JT, Gardella TJ, Jüppner H, Kronenberg H. The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues. Osteoporos Int. 1997; 7 Suppl 3:S169-73. PMID: 9536326.
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  73. Bergwitz C, Gardella TJ, Flannery MR, Potts JT, Kronenberg HM, Goldring SR, Jüppner H. Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction. J Biol Chem. 1996 Oct 25; 271(43):26469-72. PMID: 8900113.
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  74. Parfitt AM, Schipani E, Rao DS, Kupin W, Han ZH, Jüppner H. Hypercalcemia due to constitutive activity of the parathyroid hormone (PTH)/PTH-related peptide receptor: comparison with primary hyperparathyroidism. J Clin Endocrinol Metab. 1996 Oct; 81(10):3584-8. PMID: 8855805.
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  75. Schipani E, Langman CB, Parfitt AM, Jensen GS, Kikuchi S, Kooh SW, Cole WG, Jüppner H. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. N Engl J Med. 1996 Sep 05; 335(10):708-14. PMID: 8703170.
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  76. Gardella TJ, Luck MD, Jensen GS, Schipani E, Potts JT, Jüppner H. Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors. Endocrinology. 1996 Sep; 137(9):3936-41. PMID: 8756569.
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  77. Jongen JW, Willemstein-van Hove EC, van der Meer JM, Bos MP, Jüppner H, Segre GV, Abou-Samra AB, Feyen JH, Herrmann-Erlee MP. Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by PTH in primary fetal rat osteoblasts. J Bone Miner Res. 1996 Sep; 11(9):1218-25. PMID: 8864895.
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  78. Gardella TJ, Luck MD, Jensen GS, Usdin TB, Jüppner H. Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist. J Biol Chem. 1996 Aug 16; 271(33):19888-93. PMID: 8702701.
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  79. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 1996 Aug 02; 273(5275):663-6. PMID: 8662561.
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  80. Maeda S, Wu S, Jüppner H, Green J, Aragay AM, Fagin JA, Clemens TL. Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells. Endocrinology. 1996 Aug; 137(8):3154-62. PMID: 8754733.
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  81. Jüppner H, Schipani E. Receptors for parathyroid hormone and parathyroid hormone-related peptide: from molecular cloning to definition of diseases. Curr Opin Nephrol Hypertens. 1996 Jul; 5(4):300-6. PMID: 8823526.
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  82. Goodman WG, Belin T, Gales B, Juppner H, Segre GV, Salusky IB. Calcium-regulated parathyroid hormone release in patients with mild or advanced secondary hyperparathyroidism. Kidney Int. 1995 Nov; 48(5):1553-8. PMID: 8544413.
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  83. Inomata N, Akiyama M, Kubota N, Jüppner H. Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84) Endocrinology. 1995 Nov; 136(11):4732-40. PMID: 7588200.
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  84. Lee C, Luck MD, Jüppner H, Potts JT, Kronenberg HM, Gardella TJ. Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop. Mol Endocrinol. 1995 Oct; 9(10):1269-78. PMID: 8544835.
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  85. Bruns ME, Ferguson JE, Bruns DE, Burton DW, Brandt DW, Jüppner H, Segre GV, Deftos LJ. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function. Am J Obstet Gynecol. 1995 Sep; 173(3 Pt 1):739-46. PMID: 7573236.
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  86. Jüppner H. Functional properties of the PTH/PTHrP receptor. Bone. 1995 Aug; 17(2 Suppl):39S-42S. PMID: 8579896.
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  87. Jongen JW, Willemstein-Van Hove EC, Van der Meer JM, Bos MP, Jüppner H, Segre GV, Abou-Samra AB, Feyen JH, Herrmann-Erlee MP. Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by transforming growth factor-beta in primary fetal rat osteoblasts. Endocrinology. 1995 Aug; 136(8):3260-6. PMID: 7628359.
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  88. Orloff JJ, Kats Y, Urena P, Schipani E, Vasavada RC, Philbrick WM, Behal A, Abou-Samra AB, Segre GV, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology. 1995 Jul; 136(7):3016-23. PMID: 7789327.
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  89. Iida-Klein A, Guo J, Xie LY, Jüppner H, Potts JT, Kronenberg HM, Bringhurst FR, Abou-Samra AB, Segre GV. Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C. J Biol Chem. 1995 Apr 14; 270(15):8458-65. PMID: 7721741.
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  90. Schipani E, Kruse K, Jüppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 1995 Apr 07; 268(5207):98-100. PMID: 7701349.
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  91. Abou-Samra AB, Goldsmith PK, Xie LY, Jüppner H, Spiegel AM, Segre GV. Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone. Endocrinology. 1994 Dec; 135(6):2588-94. PMID: 7988447.
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  92. Gelbert L, Schipani E, Jüppner H, Abou-Samra AB, Segre GV, Naylor S, Drabkin H, Heath H. Chromosomal localization of the parathyroid hormone/parathyroid hormone-related protein receptor gene to human chromosome 3p21.1-p24.2. J Clin Endocrinol Metab. 1994 Oct; 79(4):1046-8. PMID: 7962272.
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  93. Lee C, Gardella TJ, Abou-Samra AB, Nussbaum SR, Segre GV, Potts JT, Kronenberg HM, Jüppner H. Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding. Endocrinology. 1994 Oct; 135(4):1488-95. PMID: 7523099.
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  94. Gardella TJ, Jüppner H, Wilson AK, Keutmann HT, Abou-Samra AB, Segre GV, Bringhurst FR, Potts JT, Nussbaum SR, Kronenberg HM. Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor. Endocrinology. 1994 Sep; 135(3):1186-94. PMID: 8070362.
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  95. Okano K, Wu S, Huang X, Pirola CJ, Juppner H, Abou-Samra AB, Segre GV, Iwasaki K, Fagin JA, Clemens TL. Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin-II and PTHrP. Endocrinology. 1994 Sep; 135(3):1093-9. PMID: 8070351.
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  96. Bergwitz C, Abou-Samra AB, Hesch RD, Jüppner H. Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2). Biochim Biophys Acta. 1994 Jul 21; 1222(3):447-56. PMID: 8038214.
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  97. Schipani E, Hustmyer FG, Bergwitz C, Jüppner H. Polymorphism in exon M7 of the PTHR gene. Hum Mol Genet. 1994 Jul; 3(7):1210. PMID: 7981709.
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  98. Jüppner H. Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors. Curr Opin Nephrol Hypertens. 1994 Jul; 3(4):371-8. PMID: 8076140.
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  99. Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH, Jüppner H, Potts JT, Segre GV, Kronenberg HM, et al. The rat, mouse, and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994 Jun 15; 201(2):1058. PMID: 8002976.
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  100. Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH, Jüppner H, Potts JT, Segre GV, Kronenberg HM, et al. The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994 May 16; 200(3):1290-9. PMID: 8185578.
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  101. McCauley LK, Beecher CA, Melton ME, Werkmeister JR, Jüppner H, Abou-Samra AB, Segre GV, Rosol TJ. Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells. Mol Cell Endocrinol. 1994 May; 101(1-2):331-6. PMID: 9397968.
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  102. Fukayama S, Schipani E, Jüppner H, Lanske B, Kronenberg HM, Abou-Samra AB, Bringhurst FR. Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells. Endocrinology. 1994 Apr; 134(4):1851-8. PMID: 8137752.
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  103. Ferguson JE, Seaner R, Bruns DE, Redick JA, Mills SE, Jüppner H, Segre GV, Bruns ME. Expression of parathyroid hormone-related protein and its receptor in human umbilical cord: evidence for a paracrine system involving umbilical vessels. Am J Obstet Gynecol. 1994 Apr; 170(4):1018-24; discussion 1024-6. PMID: 8166185.
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  104. Jüppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT, Kronenberg HM, Abou-Samra AB, Segre GV, Gardella TJ. The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34). Endocrinology. 1994 Feb; 134(2):879-84. PMID: 8299582.
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  105. Ureña P, Iida-Klein A, Kong XF, Jüppner H, Kronenberg HM, Abou-Samra AB, Segre GV. Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells. Endocrinology. 1994 Jan; 134(1):451-6. PMID: 8275958.
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  106. Olstad OK, Morrison NE, Jemtland R, Jüppner H, Segre GV, Gautvik KM. Differences in binding affinities of human PTH(1-84) do not alter biological potency: a comparison between chemically synthesized hormone, natural and mutant forms. Peptides. 1994; 15(7):1261-5. PMID: 7854979.
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  107. Ureña P, Abou Samra AB, Jüppner H, Kong XF, Lee K, Bringhurst FR, Segre GV. [Mode of action of parathyroid hormone (PTH) and PTH-related peptide (PTHrP) in target organs]. Ann Endocrinol (Paris). 1994; 55(5):133-41. PMID: 7857077.
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  108. Abou-Samra AB, Jüppner H, Kong XF, Schipani E, Iida-Klein A, Karga H, Urena P, Gardella TF, Potts JT, Kronenberg HM, et al. Structure, function, and expression of the receptor for parathyroid hormone and parathyroid hormone-related peptide. Adv Nephrol Necker Hosp. 1994; 23:247-64. PMID: 8154357.
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  109. Hellman P, Hellman B, Juhlin C, Jüppner H, Rastad J, Ridefelt P, Akerström G. Regulation of proliferation in JEG-3 cells by a 500-kDa Ca2+ sensor and parathyroid hormone-related protein. Arch Biochem Biophys. 1993 Dec; 307(2):379-85. PMID: 8274025.
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  110. Wu S, Pirola CJ, Green J, Yamaguchi DT, Okano K, Jueppner H, Forrester JS, Fagin JA, Clemens TL. Effects of N-terminal, midregion, and C-terminal parathyroid hormone-related peptides on adenosine 3',5'-monophosphate and cytoplasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells. Endocrinology. 1993 Dec; 133(6):2437-44. PMID: 8243262.
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  111. Ureña P, Kong XF, Abou-Samra AB, Jüppner H, Kronenberg HM, Potts JT, Segre GV. Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology. 1993 Aug; 133(2):617-23. PMID: 8393771.
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  112. Bringhurst FR, Juppner H, Guo J, Urena P, Potts JT, Kronenberg HM, Abou-Samra AB, Segre GV. Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells. Endocrinology. 1993 May; 132(5):2090-8. PMID: 8386606.
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  113. Lee K, Deeds JD, Bond AT, Jüppner H, Abou-Samra AB, Segre GV. In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young rats. Bone. 1993 May-Jun; 14(3):341-5. PMID: 8395866.
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  114. Schipani E, Karga H, Karaplis AC, Potts JT, Kronenberg HM, Segre GV, Abou-Samra AB, Jüppner H. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology. 1993 May; 132(5):2157-65. PMID: 8386612.
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  115. Abou-Samra AB, Jüppner H, Khalifa A, Karga H, Kong XF, Schiffer-Alberts D, Xie LY, Segre GV. Parathyroid hormone (PTH) stimulates adrenocorticotropin release in AtT-20 cells stably expressing a common receptor for PTH and PTH-related peptide. Endocrinology. 1993 Feb; 132(2):801-5. PMID: 7678801.
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  116. Weiss LG, Danielson BG, Jüppner H, Ljunghall S, Wide L. Parathyroid hormone and osteocalcin levels in plasma and ultrafiltrate during hemofiltration. Scand J Urol Nephrol. 1993; 27(1):109-14. PMID: 8493457.
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  117. van de Stolpe A, Karperien M, Löwik CW, Jüppner H, Segre GV, Abou-Samra AB, de Laat SW, Defize LH. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J Cell Biol. 1993 Jan; 120(1):235-43. PMID: 8380175; PMCID: PMC2119495.
  118. Uneno S, Yamamuro T, Jüppner H, Abou-Samra AB, Keutmann HT, Potts JT, Segre GV. Solubilization of functional receptors for parathyroid hormone and parathyroid hormone-related peptide from clonal rat osteosarcoma cells, ROS17/2.8. Calcif Tissue Int. 1992 Nov; 51(5):382-6. PMID: 1333876.
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  119. Burton PB, Moniz C, Quirke P, Malik A, Bui TD, Juppner H, Segre GV, Knight DE. Parathyroid hormone-related peptide: expression in fetal and neonatal development. J Pathol. 1992 Jul; 167(3):291-6. PMID: 1517900.
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  120. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2732-6. PMID: 1313566; PMCID: PMC48736.
  121. Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J, et al. Characterization of cloned PTH/PTHrP receptors. J Endocrinol Invest. 1992; 15(9 Suppl 6):11-7. PMID: 1338633.
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  122. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM, et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 1991 Nov 15; 254(5034):1024-6. PMID: 1658941.
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  123. Bergwitz C, Madoff S, Abou-Samra AB, Jüppner H. Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis. Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1391-9. PMID: 1718269.
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  124. Motokura T, Bloom T, Kim HG, Jüppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. 1991 Apr 11; 350(6318):512-5. PMID: 1826542.
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  125. Jüppner H, Hesch RD. Biochemical characterization of cellular hormone receptors. Curr Top Pathol. 1991; 83:53-69. PMID: 1672514.
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  126. Arnold A, Motokura T, Bloom T, Kronenberg H, Ruderman J, Jüppner H, Kim HG. The putative oncogene PRAD1 encodes a novel cyclin. Cold Spring Harb Symp Quant Biol. 1991; 56:93-7. PMID: 1840271.
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  127. Jüppner H, Abou-Samra AB, Uneno S, Schipani E, Keutmann HT, Potts JT, Segre GV. Properties of amino-terminal parathyroid hormone-related peptides modified at positions 11-13. Peptides. 1990 Nov-Dec; 11(6):1139-42. PMID: 1965028.
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  128. Jüppner H, Hoyer PF, Latta K, Winkler L, Offner G, Brodehl J. Efficacy of calcium carbonate and low-dose vitamin D/1,25(OH)2D3 in reducing the risk of developing renal osteodystrophy in children on continuous ambulatory peritoneal dialysis. Pediatr Nephrol. 1990 Nov; 4(6):614-7. PMID: 2088463.
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  129. Jüppner H, Abou-Samra AB, Uneno S, Keutmann HT, Potts JT, Segre GV. Preparation and characterization of [N alpha-(4-azido-2-nitrophenyl)Ala1,Tyr36]-parathyroid hormone related peptide (1-36)amide: a high-affinity, partial agonist having high cross-linking efficiency with its receptor on ROS 17/2.8 cells. Biochemistry. 1990 Jul 31; 29(30):6941-6. PMID: 2171636.
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  130. Burton PB, Moniz C, Quirke P, Tzannatos C, Pickles A, Dixit M, Triffit JT, Jüeppner H, Segre GV, Knight DE. Parathyroid hormone-related peptide in the human fetal uro-genital tract. Mol Cell Endocrinol. 1990 Mar 05; 69(2-3):R13-7. PMID: 2184058.
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  131. Abou-Samra AB, Freeman M, Jüppner H, Uneno S, Segre GV. Characterization of fully active biotinylated parathyroid hormone analogs. Application to fluorescence-activated cell sorting of parathyroid hormone receptor bearing cells. J Biol Chem. 1990 Jan 05; 265(1):58-62. PMID: 2152927.
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  132. Abou-Samra AB, Jueppner H, Potts JT, Segre GV. Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells. Endocrinology. 1989 Nov; 125(5):2594-9. PMID: 2477233.
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  133. Abou-Samra AB, Uneno S, Jueppner H, Keutmann H, Potts JT, Segre GV, Nussbaum SR. Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells. Endocrinology. 1989 Oct; 125(4):2215-7. PMID: 2551642.
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  134. Abou-Samra AB, Jueppner H, Westerberg D, Potts JT, Segre GV. Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells. Endocrinology. 1989 Mar; 124(3):1107-13. PMID: 2537172.
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  135. Jüppner H, Abou-Samra AB, Uneno S, Gu WX, Potts JT, Segre GV. The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem. 1988 Jun 25; 263(18):8557-60. PMID: 2837457.
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  136. Müller W, Peter HH, Wilken M, Jüppner H, Kallfelz HC, Krohn HP, Miller K, Rieger CH. The DiGeorge syndrome. I. Clinical evaluation and course of partial and complete forms of the syndrome. Eur J Pediatr. 1988 Jun; 147(5):496-502. PMID: 3044796.
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  137. Offner G, Hoyer PF, Galaske R, Oemar B, Jueppner H, Kroeger C. Release of human natriuretic peptide in kidney transplantation. Contrib Nephrol. 1988; 67:48-52. PMID: 2974794.
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  138. Offner G, Hoyer PF, Jüppner H, Krohn HP, Brodehl J. Somatic growth after kidney transplantation. Beneficial effect of cyclosporine in comparison with conventional immunosuppression. Am J Dis Child. 1987 May; 141(5):541-6. PMID: 3554980.
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  139. Bogin E, Chagnac A, Jüppner H, Levi J. Effect of verapamil on plasma parathyroid hormone. J Clin Chem Clin Biochem. 1987 Feb; 25(2):83-5. PMID: 3572310.
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  140. Jüppner H, Schettler T, Giebel G, Wenner S, Hesch RD. Radioimmunoassay for human osteocalcin using an antibody raised against the synthetic human (h37-49) sequence. Calcif Tissue Int. 1986 Nov; 39(5):310-5. PMID: 3102020.
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  141. Jüppner H, Brabant G, Kapteina U, Kirschner M, Klein H, Hesch RD. Direct radioimmunoassay for human atrial natriuretic peptide (hANP) and its clinical evaluation. Biochem Biophys Res Commun. 1986 Sep 30; 139(3):1215-23. PMID: 2945560.
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  142. Jüppner H, Rittinghaus EF, Ahlgrimm M, Burdelski M, Dralle H. C-terminal PTH (70-84) after biliary ligation in rats: implications for the diagnostic importance in hepatobiliary disease. Biochem Biophys Res Commun. 1986 Sep 14; 139(2):633-6. PMID: 3767981.
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  143. Jüppner H, Atkinson M, Ringe B, Krohn HP, Hesch RD. [Mid C regional parathyroid hormone in the clinical workup: diagnostic value in extrarenal (primary) and renal (secondary) hyperparathyroidism]. Klin Wochenschr. 1986 Mar 17; 64(6):281-6. PMID: 3520130.
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  144. Radeke HH, Auf'mkolk B, Jüppner H, Krohn HP, Keck E, Hesch RD. Multiple pre- and postreceptor defects in pseudohypoparathyroidism (a multicenter study with twenty four patients). J Clin Endocrinol Metab. 1986 Feb; 62(2):393-402. PMID: 3001127.
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  145. Brabant G, Jüppner H, Kirschner M, Böker K, Schmidt FW, Hesch RD. Human atrial natriuretic peptide (ANP) for the treatment of patients with liver cirrhosis and ascites. Klin Wochenschr. 1986; 64 Suppl 6:108-11. PMID: 2948056.
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  146. Rittinghaus EF, Jüppner H, Burdelski M, Hesch RD. Selective determination of C-terminal (70-84) hPTH: elevated concentrations in cholestatic liver disease. Acta Endocrinol (Copenh). 1986 Jan; 111(1):62-8. PMID: 3946104.
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  147. Jüppner H, Atkinson MJ, Baethke R, Hesch RD. Autoantibodies against parathyroid hormone in a patient with terminal renal insufficiency. Lancet. 1984 Jun 23; 1(8391):1379-81. PMID: 6145835.
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  148. Niepel B, Radeke H, Atkinson MJ, Jueppner H, Hesch RD. A homologous biological probe for parathyroid hormone in human serum. J Immunoassay. 1983; 4(1):21-47. PMID: 6853727.
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  149. Jüppner H, Hesch RD. Inhibition of renal adenylate cyclase by plasma from uremic patients. J Endocrinol Invest. 1982 Sep-Oct; 5(5):303-9. PMID: 7153474.
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  150. Jüppner H, Butz R, Casaretto M, Zahn H, Hesch RD. Characterization of two anti-human parathyrin antisera. J Clin Chem Clin Biochem. 1982 Apr; 20(4):175-80. PMID: 7077233.
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  151. Atkinson MJ, Jüppner H, Niepel B, Casaretto M, Zahn H, Hesch RD. Characterisation of the binding sites of anti-parathyroid hormone antisera using synthetic parathyroid hormone peptides. J Immunoassay. 1982; 3(1):31-51. PMID: 7130399.
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  152. Atkinson MJ, Niepel B, Jüppner H, Butz R, Casaretto M, Zahn H, Hehrmann R, Hesch RD. Homologous radioimmunoassay for human mid-regional parathyroid hormone. J Endocrinol Invest. 1981 Jul-Sep; 4(3):363-6. PMID: 7320439.
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  153. Wood WG, Butz R, Casaretto M, Hehrmann R, Jüppner H, Marschner I, Wachter C, Zahn H, Hesch RD. Preliminary results on the use of an antiserum to human parathyrin in a homologous radioimmunoassay. J Clin Chem Clin Biochem. 1980 Nov; 18(11):789-95. PMID: 7192307.
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  154. Jüppner H, Mohr H, Hesch RD. Adsorption of parathyrin: pitfall for solid phase assays using radiolabelled antibodies? J Clin Chem Clin Biochem. 1980 Sep; 18(9):585-90. PMID: 7441186.
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  155. Mohr H, Hesch RD, McIntosh CH, Jüppner H. Parathyroid hormone fragments in secretory granules of human parathyroid adenomata. Eur J Clin Invest. 1980 Aug; 10(4):317-23. PMID: 6775959.
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  156. Juppner H, Hesch RD. Parathormone receptor binding and the influence of membrane degradation of the hormone. J Immunoassay. 1980; 1(1):39-55. PMID: 6262383.
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  157. Bialasiewicz AA, Jüppner H, Diehl V, Hesch RD. Binding of bovine parathyroid hormone to surface receptors of cultured B-lymphocytes. Biochim Biophys Acta. 1979 May 16; 584(3):467-78. PMID: 222343.
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  158. Jüppner H, Bialasiewicz AA, Hesch RD. Autoantibodies to parathyroid hormone receptor. Lancet. 1978 Dec 09; 2(8102):1222-4. PMID: 82734.
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  159. Sraer J, Sraer JD, Chansel D, Jueppner H, Hesch RD, Ardaillou R. Evidence for glomerular receptors for parathyroid hormone. Am J Physiol. 1978 Aug; 235(2):F96-103. PMID: 210677.
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  160. Höffken B, Ködding R, Von Zur Mühlen A, Hehrmann T, Jüppner H, Hesch RD. Regulation of thyroid hormone metabolism in rat liver fractions. Biochim Biophys Acta. 1978 Feb 13; 539(1):114-24. PMID: 23865.
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  161. Lustenberger N, Hehrmann R, Jüppner H, Delling G, Hesch RD. Kinetics of PTH metabolism and PTH fragments in chronic renal failure. Contrib Nephrol. 1978; 13:115-24. PMID: 710134.
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  162. Hesch RD, Ebel H, Hehrmann R, Jüppner H. Endocrinological aspects of PTH metabolism in the kidney. Contrib Nephrol. 1978; 13:104-14. PMID: 213235.
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  163. Lustenberger N, Hehrmann R, Jüppner H, Hesch RD. Parathyroid hormone metabolism in normal and uremic man. Adv Exp Med Biol. 1978; 103:529-36. PMID: 717122.
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  164. Hesch RD, Gatz J, Jüppner H, Stubbe P. TBG-dependency of age related variations of thyroxine and triiodothyronine. Horm Metab Res. 1977 Mar; 9(2):141-6. PMID: 405301.
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  165. Jüppner H, Hesch RD. Inhibition of PTH receptor binding and PTH mediated adenylate cyclase activity by somatostatin. Biochem Biophys Res Commun. 1976 Oct 04; 72(3):945-51. PMID: 186067.
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  166. Jüppner H, Hesch RD. Enzymatic modification of bovine and ovine parathyrin receptor. FEBS Lett. 1976 Sep 01; 67(3):281-3. PMID: 183982.
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  167. Nolte H, Mühlen A, Hesch RD, Pape J, Warnecke U, Jüppner H. [Calculation of radioimmunochemical determinations by "spline approximation" (author's transl)]. J Clin Chem Clin Biochem. 1976 Jun; 14(6):253-9. PMID: 956731.
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  168. Köbberling J, Jüppner H, Hesch RD. The stimulation of growth hormone release by ACTH and its inhibition by somatostatin. Acta Endocrinol (Copenh). 1976 Feb; 81(2):263-9. PMID: 174366.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.