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Patrick M. Fuller, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS103161 (FULLER, PATRICK M) Jul 1, 2017 - Apr 30, 2022
    NIH/NINDS
    Dissection of a novel inhibitory hypothalamic arousal circuit
    Role: Principal Investigator
  2. R01NS092652 (FULLER, PATRICK M) Jul 15, 2015 - Apr 30, 2020
    NIH/NINDS
    Brainstem regulation of sleep
    Role: Principal Investigator
  3. R01NS073613 (FULLER, PATRICK M) Feb 1, 2011 - Jan 31, 2020
    NIH/NINDS
    Molecular-genetic dissection of basal forebrain circuitry regulating arousal
    Role: Principal Investigator
  4. F32NS057119 (FULLER, PATRICK MICHAEL) Apr 1, 2007 - Mar 31, 2009
    NIH/NINDS
    Food Entrainable Circadianm Oscillator
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Fuller PM, Eikermann M. Genomic consequences of sleep restriction: the devil is in the details. Anaesthesia. 2018 Nov 01. PMID: 30383307.
    View in: PubMed
  2. Brown J, Sagante A, Mayer T, Wright A, Bugescu R, Fuller PM, Leinninger G. Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance. Endocrinology. 2018 Sep 01; 159(9):3158-3176. PMID: 30010830.
    View in: PubMed
  3. Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018 Jul 23; 28(14):2291-2301.e5. PMID: 30017482.
    View in: PubMed
  4. Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM. Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control. J Neurosci. 2018 May 30; 38(22):5168-5181. PMID: 29735555.
    View in: PubMed
  5. Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 May; 21(5):717-724. PMID: 29632359.
    View in: PubMed
  6. Hooper A, Fuller PM, Maguire J. Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability. PLoS One. 2018; 13(1):e0191363. PMID: 29346425.
    View in: PubMed
  7. Peever J, Fuller PM. The Biology of REM Sleep. Curr Biol. 2017 Nov 20; 27(22):R1237-R1248. PMID: 29161567.
    View in: PubMed
  8. Pedersen NP, Ferrari L, Venner A, Wang JL, Abbott SBG, Vujovic N, Arrigoni E, Saper CB, Fuller PM. Supramammillary glutamate neurons are a key node of the arousal system. Nat Commun. 2017 11 10; 8(1):1405. PMID: 29123082.
    View in: PubMed
  9. Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB. A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron. 2017 Dec 06; 96(5):1153-1167.e5. PMID: 29103805.
    View in: PubMed
  10. Guo CN, Yang WJ, Zhan SQ, Yang XF, Chen MC, Fuller PM, Lu J. Targeted disruption of supraspinal motor circuitry reveals a distributed network underlying Restless Legs Syndrome (RLS)-like movements in the rat. Sci Rep. 2017 Aug 29; 7(1):9905. PMID: 28852150.
    View in: PubMed
  11. Woodworth HL, Batchelor HM, Beekly BG, Bugescu R, Brown JA, Kurt G, Fuller PM, Leinninger GM. Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance. Cell Rep. 2017 Aug 22; 20(8):1881-1892. PMID: 28834751.
    View in: PubMed
  12. Schallner N, Lieberum JL, Gallo D, LeBlanc RH, Fuller PM, Hanafy KA, Otterbein LE. Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice. Stroke. 2017 09; 48(9):2565-2573. PMID: 28747460.
    View in: PubMed
  13. Anaclet C, Griffith K, Fuller PM. Activation of the GABAergic Parafacial Zone Maintains Sleep and Counteracts the Wake-Promoting Action of the Psychostimulants Armodafinil and Caffeine. Neuropsychopharmacology. 2018 Jan; 43(2):415-425. PMID: 28722021.
    View in: PubMed
  14. Rukhadze I, Carballo NJ, Bandaru SS, Malhotra A, Fuller PM, Fenik VB. Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles. Respir Physiol Neurobiol. 2017 10; 244:41-50. PMID: 28711601.
    View in: PubMed
  15. Saper CB, Fuller PM. Wake-sleep circuitry: an overview. Curr Opin Neurobiol. 2017 06; 44:186-192. PMID: 28577468.
    View in: PubMed
  16. Anaclet C, Fuller PM. Brainstem regulation of slow-wave-sleep. Curr Opin Neurobiol. 2017 06; 44:139-143. PMID: 28500870.
    View in: PubMed
  17. Chen MC, Vetrivelan R, Guo CN, Chang C, Fuller PM, Lu J. Ventral medullary control of rapid eye movement sleep and atonia. Exp Neurol. 2017 04; 290:53-62. PMID: 28077261.
    View in: PubMed
  18. Kroeger D, Ferrari LL, Petit G, Mahoney CE, Fuller PM, Arrigoni E, Scammell TE. Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice. J Neurosci. 2017 02 01; 37(5):1352-1366. PMID: 28039375.
    View in: PubMed
  19. Qiu MH, Chen MC, Fuller PM, Lu J. Stimulation of the Pontine Parabrachial Nucleus Promotes Wakefulness via Extra-thalamic Forebrain Circuit Nodes. Curr Biol. 2016 09 12; 26(17):2301-12. PMID: 27546576.
    View in: PubMed
  20. Venner A, Anaclet C, Broadhurst RY, Saper CB, Fuller PM. A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus. Curr Biol. 2016 08 22; 26(16):2137-43. PMID: 27426511.
    View in: PubMed
  21. Arrigoni E, Chen MC, Fuller PM. The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep. J Physiol. 2016 10 01; 594(19):5391-414. PMID: 27060683.
    View in: PubMed
  22. Peever J, Fuller PM. Neuroscience: A Distributed Neural Network Controls REM Sleep. Curr Biol. 2016 Jan 11; 26(1):R34-5. PMID: 26766231.
    View in: PubMed
  23. Anaclet C, Pedersen NP, Ferrari LL, Venner A, Bass CE, Arrigoni E, Fuller PM. Basal forebrain control of wakefulness and cortical rhythms. Nat Commun. 2015 Nov 03; 6:8744. PMID: 26524973; PMCID: PMC4659943.
  24. Fuller PM, Yamanaka A, Lazarus M. How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake. Temperature (Austin). 2015 Jul-Sep; 2(3):406-17. PMID: 27227054; PMCID: PMC4843941.
  25. Gompf HS, Budygin EA, Fuller PM, Bass CE. Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals. Front Behav Neurosci. 2015; 9:152. PMID: 26190981; PMCID: PMC4488755.
  26. Sherman D, Fuller PM, Marcus J, Yu J, Zhang P, Chamberlin NL, Saper CB, Lu J. Anatomical Location of the Mesencephalic Locomotor Region and Its Possible Role in Locomotion, Posture, Cataplexy, and Parkinsonism. Front Neurol. 2015; 6:140. PMID: 26157418; PMCID: PMC4478394.
  27. Unger EK, Burke KJ, Yang CF, Bender KJ, Fuller PM, Shah NM. Medial amygdalar aromatase neurons regulate aggression in both sexes. Cell Rep. 2015 Feb 03; 10(4):453-62. PMID: 25620703; PMCID: PMC4349580.
  28. Chen MC, Ferrari L, Sacchet MD, Foland-Ross LC, Qiu MH, Gotlib IH, Fuller PM, Arrigoni E, Lu J. Identification of a direct GABAergic pallidocortical pathway in rodents. Eur J Neurosci. 2015 Mar; 41(6):748-59. PMID: 25581560; PMCID: PMC4363158.
  29. Gompf HS, Fuller PM, Hattar S, Saper CB, Lu J. Impaired circadian photosensitivity in mice lacking glutamate transmission from retinal melanopsin cells. J Biol Rhythms. 2015 Feb; 30(1):35-41. PMID: 25512304; PMCID: PMC4316665.
  30. Anaclet C, Ferrari L, Arrigoni E, Bass CE, Saper CB, Lu J, Fuller PM. Corrigendum: The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. Nat Neurosci. 2014 Nov 21; 17(12):1841. PMID: 25413100.
    View in: PubMed
  31. Yazaki-Sugiyama Y, Yanagihara S, Fuller PM, Lazarus M. Acute inhibition of a cortical motor area impairs vocal control in singing zebra finches. Eur J Neurosci. 2015 Jan; 41(1):97-108. PMID: 25354166.
    View in: PubMed
  32. Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13193-8. PMID: 25157144; PMCID: PMC4246954.
  33. Anaclet C, Ferrari L, Arrigoni E, Bass CE, Saper CB, Lu J, Fuller PM. The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. Nat Neurosci. 2014 Sep; 17(9):1217-24. PMID: 25129078; PMCID: PMC4214681.
  34. Vetrivelan R, Saper CB, Fuller PM. Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep. 2014; 6:57-63. PMID: 24833927; PMCID: PMC4014362.
  35. Taylor K, Kleinhesselink K, George MD, Morgan R, Smallwood T, Hammonds AS, Fuller PM, Saelao P, Alley J, Gibbs AG, Hoshizaki DK, von Kalm L, Fuller CA, Beckingham KM, Kimbrell DA. Toll mediated infection response is altered by gravity and spaceflight in Drosophila. PLoS One. 2014; 9(1):e86485. PMID: 24475130; PMCID: PMC3901686.
  36. Pei H, Sutton AK, Burnett KH, Fuller PM, Olson DP. AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding. Mol Metab. 2014 Apr; 3(2):209-15. PMID: 24634830; PMCID: PMC3953699.
  37. Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE. Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013 Jun 05; 33(23):9743-51. PMID: 23739971; PMCID: PMC3714797.
  38. Kaur S, Pedersen NP, Yokota S, Hur EE, Fuller PM, Lazarus M, Chamberlin NL, Saper CB. Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal. J Neurosci. 2013 May 01; 33(18):7627-40. PMID: 23637157; PMCID: PMC3674488.
  39. Anaclet C, Lin JS, Vetrivelan R, Krenzer M, Vong L, Fuller PM, Lu J. Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. J Neurosci. 2012 Dec 12; 32(50):17970-6. PMID: 23238713; PMCID: PMC3564016.
  40. Vetrivelan R, Fuller PM, Yokota S, Lu J, Saper CB. Metabolic effects of chronic sleep restriction in rats. Sleep. 2012 Nov 01; 35(11):1511-20. PMID: 23115400; PMCID: PMC3466798.
  41. Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26; 151(3):645-57. PMID: 23101631; PMCID: PMC3500616.
  42. Thankachan S, Fuller PM, Lu J. Movement- and behavioral state-dependent activity of pontine reticulospinal neurons. Neuroscience. 2012 Sep 27; 221:125-39. PMID: 22796072; PMCID: PMC3424299.
  43. Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS One. 2011; 6(10):e24998. PMID: 22043278; PMCID: PMC3197189.
  44. Fuller PM, Fuller P, Sherman D, Pedersen NP, Saper CB, Lu J. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol. 2011 Apr 01; 519(5):933-56. PMID: 21280045; PMCID: PMC3119596.
  45. Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron. 2010 Dec 22; 68(6):1023-42. PMID: 21172606; PMCID: PMC3026325.
  46. Gompf HS, Mathai C, Fuller PM, Wood DA, Pedersen NP, Saper CB, Lu J. Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. J Neurosci. 2010 Oct 27; 30(43):14543-51. PMID: 20980612; PMCID: PMC2989851.
  47. Qiu MH, Vetrivelan R, Fuller PM, Lu J. Basal ganglia control of sleep-wake behavior and cortical activation. Eur J Neurosci. 2010 Feb; 31(3):499-507. PMID: 20105243; PMCID: PMC3928571.
  48. Anaclet C, Pedersen NP, Fuller PM, Lu J. Brainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleep. PLoS One. 2010 Jan 20; 5(1):e8788. PMID: 20098748; PMCID: PMC2808333.
  49. Ingham ES, Günhan E, Fuller PM, Fuller CA. Immunotoxin-induced ablation of melanopsin retinal ganglion cells in a non-murine mammalian model. J Comp Neurol. 2009 Sep 10; 516(2):125-40. PMID: 19575450.
    View in: PubMed
  50. Fuller PM, Lu J, Saper CB. Standards of evidence in chronobiology: A response. J Circadian Rhythms. 2009 Jul 22; 7:9. PMID: 19624818; PMCID: PMC2724488.
  51. Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci. 2009 Jul 22; 29(29):9361-9. PMID: 19625526; PMCID: PMC2758912.
  52. Greco MA, Fuller PM, Jhou TC, Martin-Schild S, Zadina JE, Hu Z, Shiromani P, Lu J. Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus. Brain Res. 2008 Dec 15; 1245:96-107. PMID: 18840417; PMCID: PMC2753822.
  53. Pedersen NP, Fuller PM, Lu J, Saper CB. In the flicker of an eye. J Physiol. 2008 Jul 15; 586(14):3305-6. PMID: 18625803; PMCID: PMC2538807.
  54. Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms. Science. 2008 May 23; 320(5879):1074-7. PMID: 18497298; PMCID: PMC3489954.
  55. Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present. J Physiol. 2007 Nov 01; 584(Pt 3):735-41. PMID: 17884926; PMCID: PMC2276987.
  56. Saper CB, Fuller PM. Inducible clocks: living in an unpredictable world. Cold Spring Harb Symp Quant Biol. 2007; 72:543-50. PMID: 18419313.
    View in: PubMed
  57. Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback. J Biol Rhythms. 2006 Dec; 21(6):482-93. PMID: 17107938.
    View in: PubMed
  58. Fuller PM, Fuller CA. Genetic evidence for a neurovestibular influence on the mammalian circadian pacemaker. J Biol Rhythms. 2006 Jun; 21(3):177-84. PMID: 16731657.
    View in: PubMed
  59. Fuller PM, Baldwin KM, Fuller CA. Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R442-8. PMID: 16179485.
    View in: PubMed
  60. Hilder TL, Baer LA, Fuller PM, Fuller CA, Grindeland RE, Wade CE, Graves LM. Insulin-independent pathways mediating glucose uptake in hindlimb-suspended skeletal muscle. J Appl Physiol (1985). 2005 Dec; 99(6):2181-8. PMID: 16099889.
    View in: PubMed
  61. Fuller PM, Jones TA, Jones SM, Fuller CA. Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei. Neuroscience. 2004; 129(2):461-71. PMID: 15501603.
    View in: PubMed
  62. Fuller PM, Jones TA, Jones SM, Fuller CA. Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection? Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15723-8. PMID: 12434016; PMCID: PMC137783.
  63. Fuller PM, Warden CH, Barry SJ, Fuller CA. Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice. J Appl Physiol (1985). 2000 Oct; 89(4):1491-8. PMID: 11007587.
    View in: PubMed
  64. Hoban-Higgins TM, Murakami DM, Tang IH, Fuller PM, Fuller CA. Development of circadian rhythms in rat pups exposed to microgravity during gestation. J Gravit Physiol. 1999 Oct; 6(2):71-9. PMID: 11543088.
    View in: PubMed
  65. Wilson S, Johns PI, Fuller PM. Accessory innervation of mandibular anterior teeth in cats: a horseradish peroxidase study. Brain Res. 1984 Apr 30; 298(2):392-6. PMID: 6609747.
    View in: PubMed
  66. Wilson S, Winfrey J, Fuller PM, Johns P. A horseradish peroxidase study of feline mandibular incisors. Brain Res. 1983 Feb 07; 260(2):287-90. PMID: 6600958.
    View in: PubMed
  67. Wilson S, Fuller PM, Winfrey J. Histochemical evidence of strictly ipsilateral innervation of maxillary canine teeth in cats. Exp Neurol. 1980 Oct; 70(1):138-45. PMID: 6968275.
    View in: PubMed
  68. Fuller PM, Wilson S, Winfrey J. A lack of peripheral transmedian innervation of feline mandibular canine teeth as determined by horseradish peroxidase. Brain Res. 1979 Dec 28; 179(2):362-6. PMID: 509244.
    View in: PubMed
  69. Fuller PM. Afferent and efferent components of the facial nerve in the bullfrog (Rana catesbeiana). J Morphol. 1979 Feb; 159(2):245-52. PMID: 310889.
    View in: PubMed
  70. Butler AB, Willmore LJ, Fuller PM, Bass NH. Cytochemical affinity of pyramidal cell dendrites for divalent cobalt during initiation and calcium-induced blockade of epileptiform discharge. Exp Neurol. 1977 Aug; 56(2):386-99. PMID: 885196.
    View in: PubMed
  71. Butler AB, Willmore LJ, Fuller PM, Bass NH. Focal alteration of dendrites and astrocytes in rat cerebral cortex during initiation of cobalt-induced epileptiform activity. Exp Neurol. 1976 Apr; 51(1):216-28. PMID: 1261636.
    View in: PubMed
  72. Fuller PM, Prior DJ. Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS. Brain Res. 1975 May 02; 88(2):211-20. PMID: 1097054.
    View in: PubMed
  73. Willmore LJ, Fuller PM, Butler AB, Bass NH. Neuronal compartmentation of ionic cobalt in rat cerebral cortex during initiation of epileptiform activity. Exp Neurol. 1975 May; 47(2):280-9. PMID: 1140232.
    View in: PubMed
  74. Prior DJ, Fuller PM. The use of a cobalt iontophoresis technique for identification of the mesencephalic trigeminal nucleus. Brain Res. 1973 Dec 21; 64:472-5. PMID: 4544456.
    View in: PubMed
  75. Fuller PM, Ebbesson SO. Central projections of the trigeminal nerve in the bull frog (Rana catesbeiana). J Comp Neurol. 1973 Nov 15; 152(2):193-9. PMID: 4543413.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.