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profileTakatoshi Mochizuki, Ph.D.

TitleAssistant Professor of Neurology
InstitutionBeth Israel Deaconess Medical Center
DepartmentNeurology
AddressBeth Israel Deaconess Medical Center
Neurology - CLS 706
3 Blackfan Circle
Boston MA 02115
Phone617/735-3261
Fax617/735-3249
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01HL095491     (SAPER, CLIFFORD B)Apr 1, 2009 - May 31, 2020
NIH/NHLBI
Mechanisms of Arousal in Sleep Apnea
Role: Co-Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. Descending projections from the basal forebrain to the orexin neurons in mice. J Comp Neurol. 2017 May 01; 525(7):1668-1684. PMID: 27997037.
    View in: PubMed
  2. Yoshida F, Okusu Y, Wada A, Hiroe Y, Yano H, Miyazaki T, Ishikawa H, Nakamura M, Mochizuki T. [Case Report; A case of QT prolongation and torsade de pointes associated with Solifenacin]. Nihon Naika Gakkai Zasshi. 2014 Nov 10; 103(11):2804-6. PMID: 27522821.
    View in: PubMed
  3. Kantor S, Mochizuki T, Lops SN, Ko B, Clain E, Clark E, Yamamoto M, Scammell TE. Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice. Sleep. 2013 Aug 01; 36(8):1129-38. PMID: 23904672; PMCID: PMC3700709.
  4. Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE. Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013 Jun 05; 33(23):9743-51. PMID: 23739971; PMCID: PMC3714797.
  5. Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE. Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neurosci. 2013 Jun 05; 33(23):9734-42. PMID: 23739970; PMCID: PMC3704329.
  6. Unno K, Yamoto K, Takeuchi K, Kataoka A, Ozaki T, Mochizuki T, Honda K, Miura N, Ikeda M. Acute enhancement of non-rapid eye movement sleep in rats after drinking water contaminated with cadmium chloride. J Appl Toxicol. 2014 Feb; 34(2):205-13. PMID: 23349044.
    View in: PubMed
  7. Scott MM, Marcus JN, Pettersen A, Birnbaum SG, Mochizuki T, Scammell TE, Nestler EJ, Elmquist JK, Lutter M. Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res. 2011 Sep 23; 222(2):289-94. PMID: 21377495; PMCID: PMC3474296.
  8. Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4471-6. PMID: 21368172; PMCID: PMC3060231.
  9. Diniz Behn CG, Klerman EB, Mochizuki T, Lin SC, Scammell TE. Abnormal sleep/wake dynamics in orexin knockout mice. Sleep. 2010 Mar; 33(3):297-306. PMID: 20337187; PMCID: PMC2831423.
  10. Kantor S, Mochizuki T, Janisiewicz AM, Clark E, Nishino S, Scammell TE. Orexin neurons are necessary for the circadian control of REM sleep. Sleep. 2009 Sep; 32(9):1127-34. PMID: 19750917; PMCID: PMC2737570.
  11. Arrigoni E, Mochizuki T, Scammell TE. Activation of the basal forebrain by the orexin/hypocretin neurones. Acta Physiol (Oxf). 2010 Mar; 198(3):223-35. PMID: 19723027; PMCID: PMC2938067.
  12. Clark EL, Baumann CR, Cano G, Scammell TE, Mochizuki T. Feeding-elicited cataplexy in orexin knockout mice. Neuroscience. 2009 Jul 21; 161(4):970-7. PMID: 19362119; PMCID: PMC2743520.
  13. Scammell TE, Mochizuki T. Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia? Sleep. 2009 Feb; 32(2):133-4. PMID: 19238797; PMCID: PMC2635574.
  14. Cano G, Mochizuki T, Saper CB. Neural circuitry of stress-induced insomnia in rats. J Neurosci. 2008 Oct 01; 28(40):10167-84. PMID: 18829974; PMCID: PMC2693213.
  15. Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE. Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol. 2008 Jun; 99(6):3090-103. PMID: 18417630; PMCID: PMC3065358.
  16. Terao A, Huang ZL, Wisor JP, Mochizuki T, Gerashchenko D, Urade Y, Kilduff TS. Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep. J Neurochem. 2008 May; 105(4):1480-98. PMID: 18331290; PMCID: PMC2590502.
  17. Cui Y, Kataoka Y, Inui T, Mochizuki T, Onoe H, Matsumura K, Urade Y, Yamada H, Watanabe Y. Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats. J Neurosci Res. 2008 Mar; 86(4):929-36. PMID: 17929312.
    View in: PubMed
  18. EspaƱa RA, McCormack SL, Mochizuki T, Scammell TE. Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep. 2007 Nov; 30(11):1417-25. PMID: 18041476; PMCID: PMC2082091.
  19. Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007 Sep; 10(9):1131-3. PMID: 17676060.
    View in: PubMed
  20. Mochizuki T, Klerman EB, Sakurai T, Scammell TE. Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R533-40. PMID: 16556901; PMCID: PMC2259440.
  21. Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y, Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4687-92. PMID: 16537376; PMCID: PMC1450232.
  22. Anderson MP, Mochizuki T, Xie J, Fischler W, Manger JP, Talley EM, Scammell TE, Tonegawa S. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1743-8. PMID: 15677322; PMCID: PMC547889.
  23. Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE. Behavioral state instability in orexin knock-out mice. J Neurosci. 2004 Jul 14; 24(28):6291-300. PMID: 15254084.
    View in: PubMed
  24. Okada T, Mochizuki T, Huang ZL, Eguchi N, Sugita Y, Urade Y, Hayaishi O. Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep. Biochem Biophys Res Commun. 2003 Dec 05; 312(1):29-34. PMID: 14630012.
    View in: PubMed
  25. Mochizuki T, Scammell TE. Orexin/Hypocretin: wired for wakefulness. Curr Biol. 2003 Jul 15; 13(14):R563-4. PMID: 12867050.
    View in: PubMed
  26. Huang ZL, Sato Y, Mochizuki T, Okada T, Qu WM, Yamatodani A, Urade Y, Hayaishi O. Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. J Neurosci. 2003 Jul 09; 23(14):5975-83. PMID: 12853415.
    View in: PubMed
  27. Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T, Narumiya S, Urade Y, Hayaishi O. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11674-9. PMID: 11562489; PMCID: PMC58788.
  28. Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O. An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience. 2001; 107(4):653-63. PMID: 11720788.
    View in: PubMed
  29. Tatsuta N, Suzuki N, Mochizuki T, Koya K, Kawakami M, Shishido T, Motoji N, Kuroiwa H, Shigematsu A, Chen LB. Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent. Cancer Chemother Pharmacol. 1999; 43(4):295-301. PMID: 10071980.
    View in: PubMed
  30. Kagaya Y, Weinberg EO, Ito N, Mochizuki T, Barry WH, Lorell BH. Glycolytic inhibition: effects on diastolic relaxation and intracellular calcium handling in hypertrophied rat ventricular myocytes. J Clin Invest. 1995 Jun; 95(6):2766-76. PMID: 7769117; PMCID: PMC295961.
  31. Mochizuki T, Eberli FR, Ngoy S, Apstein CS, Lorell BH. Effects of brief repetitive ischemia on contractility, relaxation, and coronary flow. Exaggerated postischemic diastolic dysfunction in pressure-overload hypertrophy. Circ Res. 1993 Sep; 73(3):550-8. PMID: 8348696.
    View in: PubMed
  32. Mochizuki T, Eberli FR, Apstein CS, Lorell BH. Exacerbation of ischemic dysfunction by angiotensin II in red cell-perfused rabbit hearts. Effects on coronary flow, contractility, and high-energy phosphate metabolism. J Clin Invest. 1992 Feb; 89(2):490-8. PMID: 1737839; PMCID: PMC442878.
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