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profileNadine Gaab, PH.D.

TitleAssociate Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Developmental Medicine Center, CHB
One Autumn Street
Boston MA 02215
Phone857/218-3021
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Collapse Overview 
Collapse overview
Our laboratory focuses on developmental cognitive neuroscience. We study cognitive processes such as auditory perception, language or reading and their neurological bases in the developing human brain. The majority of our studies involve functional magnetic resonance imaging (fMRI) but we also employ experimental behavioral studies and structural brain measurement techniques.
Our main research areas we investigate right now include:
-the neural correlates of reading and reading development (e.g.; does learning to read change your brain?)
-the relationship between auditory processing disorders and reading impairments
-the neural correlates of auditory and language processing in developmental dyslexia and specific language impairments
-the influence of musical training on language and reading development
-the development and evaluation of remediation programs for language and reading impairments
-the development of auditory and music processing and its relation to language development in typical reader

http://www.childrenshospital.org/research/gaablab


Collapse Mentoring 
Collapse completed student projects
Effects of home literacy environment on brain activity in children
Summer, 06/23/14 - 08/08/14
Neural Predictors of Developmental Dyslexia in Pre-Reading Children
Summer, 03/07/12 - 08/15/12

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01AA023503     (JACOBSON, SANDRA W.)Aug 10, 2015 - Jul 31, 2020
NIH/NIAAA
Behavioral Characteristics and Neural Correlates of Reading Impairment in FASD
Role: Principal Investigator

R01HD065762     (GAAB, NADINE)Mar 15, 2011 - Jul 31, 2021
NIH/NICHD
Examining neural mechanisms of developmental dyslexia from infancy to school-age
Role: Principal Investigator

R01HD067312     (GABRIELI, JOHN)Jan 10, 2011 - Dec 31, 2015
NIH/NICHD
Using Cognitive Neuroscience to Predict Dyslexia among Kindergarden Children
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Wang Y, Mauer MV, Raney T, Peysakhovich B, Becker BLC, Sliva DD, Gaab N. Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls. Cereb Cortex. 2017 Apr 01; 27(4):2469-2485. PMID: 27114172.
    View in: PubMed
  2. Zuk J, Bishop-Liebler P, Ozernov-Palchik O, Moore E, Overy K, Welch G, Gaab N. Revisiting the "enigma" of musicians with dyslexia: Auditory sequencing and speech abilities. J Exp Psychol Gen. 2017 Apr; 146(4):495-511. PMID: 28383990.
    View in: PubMed
  3. Langer N, Peysakhovich B, Zuk J, Drottar M, Sliva DD, Smith S, Becker BL, Grant PE, Gaab N. White Matter Alterations in Infants at Risk for Developmental Dyslexia. Cereb Cortex. 2017 Feb 01; 27(2):1027-1036. PMID: 26643353.
    View in: PubMed
  4. Raschle NM, Becker BL, Smith S, Fehlbaum LV, Wang Y, Gaab N. Investigating the Influences of Language Delay and/or Familial Risk for Dyslexia on Brain Structure in 5-Year-Olds. Cereb Cortex. 2017 Jan 01; 27(1):764-776. PMID: 26585334.
    View in: PubMed
  5. Ozernov-Palchik O, Norton ES, Sideridis G, Beach SD, Wolf M, Gabrieli JD, Gaab N. Longitudinal stability of pre-reading skill profiles of kindergarten children: implications for early screening and theories of reading. Dev Sci. 2016 Oct 17. PMID: 27747988.
    View in: PubMed
  6. Powers SJ, Wang Y, Beach SD, Sideridis GD, Gaab N. Examining the relationship between home literacy environment and neural correlates of phonological processing in beginning readers with and without a familial risk for dyslexia: an fMRI study. Ann Dyslexia. 2016 Oct; 66(3):337-360. PMID: 27550556.
    View in: PubMed
  7. Saygin ZM, Osher DE, Norton ES, Youssoufian DA, Beach SD, Feather J, Gaab N, Gabrieli JD, Kanwisher N. Connectivity precedes function in the development of the visual word form area. Nat Neurosci. 2016 Sep; 19(9):1250-5. PMID: 27500407; PMCID: PMC5003691 [Available on 03/01/17].
  8. Ozernov-Palchik O, Yu X, Wang Y, Gaab N. Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice. Curr Opin Behav Sci. 2016 Aug; 10:45-58. PMID: 27766284.
    View in: PubMed
  9. Ozernov-Palchik O, Gaab N. Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexiax. Wiley Interdiscip Rev Cogn Sci. 2016 Mar-Apr; 7(2):156-76. PMID: 26836227; PMCID: PMC4761294 [Available on 03/01/17].
  10. Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLoS One. 2015; 10(9):e0137930. PMID: 26332852; PMCID: PMC4558094.
  11. Paldino MJ, Hedges K, Gaab N, Galaburda AM, Grant PE. Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria. Behav Neurol. 2015; 2015:351391. PMID: 26180373; PMCID: PMC4477425.
  12. Im K, Raschle NM, Smith SA, Ellen Grant P, Gaab N. Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners. Cereb Cortex. 2016 Mar; 26(3):1138-48. PMID: 25576531; PMCID: PMC4757938 [Available on 03/01/17].
  13. Raschle NM, Smith SA, Zuk J, Dauvermann MR, Figuccio MJ, Gaab N. Investigating the neural correlates of voice versus speech-sound directed information in pre-school children. PLoS One. 2014; 9(12):e115549. PMID: 25532132; PMCID: PMC4274095.
  14. Shetreet E, Chierchia G, Gaab N. Linguistic inability or poor performance: Dissociating scalar implicature generation and mismatch in the developing brain. Dev Psychol. 2014 Sep; 50(9):2264-75. PMID: 25046122.
    View in: PubMed
  15. Zuk J, Benjamin C, Kenyon A, Gaab N. Behavioral and neural correlates of executive functioning in musicians and non-musicians. PLoS One. 2014; 9(6):e99868. PMID: 24937544; PMCID: PMC4061064.
  16. Langer N, Benjamin C, Minas J, Gaab N. The neural correlates of reading fluency deficits in children. Cereb Cortex. 2015 Jun; 25(6):1441-53. PMID: 24335032; PMCID: PMC4428293.
  17. Zuk J, Ozernov-Palchik O, Kim H, Lakshminarayanan K, Gabrieli JD, Tallal P, Gaab N. Enhanced syllable discrimination thresholds in musicians. PLoS One. 2013; 8(12):e80546. PMID: 24339875; PMCID: PMC3855080.
  18. Shetreet E, Chierchia G, Gaab N. When three is not some: on the pragmatics of numerals. J Cogn Neurosci. 2014 Apr; 26(4):854-63. PMID: 24168221.
    View in: PubMed
  19. Saygin ZM, Norton ES, Osher DE, Beach SD, Cyr AB, Ozernov-Palchik O, Yendiki A, Fischl B, Gaab N, Gabrieli JD. Tracking the roots of reading ability: white matter volume and integrity correlate with phonological awareness in prereading and early-reading kindergarten children. J Neurosci. 2013 Aug 14; 33(33):13251-8. PMID: 23946384; PMCID: PMC3742917.
  20. Zuk J, Andrade PE, Andrade OV, Gardiner M, Gaab N. Musical, language, and reading abilities in early Portuguese readers. Front Psychol. 2013; 4:288. PMID: 23785339; PMCID: PMC3684766.
  21. Raschle NM, Stering PL, Meissner SN, Gaab N. Altered neuronal response during rapid auditory processing and its relation to phonological processing in prereading children at familial risk for dyslexia. Cereb Cortex. 2014 Sep; 24(9):2489-501. PMID: 23599167; PMCID: PMC4184369.
  22. Shetreet E, Chierchia G, Gaab N. When some is not every: dissociating scalar implicature generation and mismatch. Hum Brain Mapp. 2014 Apr; 35(4):1503-14. PMID: 23568365.
    View in: PubMed
  23. Im K, Pienaar R, Paldino MJ, Gaab N, Galaburda AM, Grant PE. Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex. 2013 Dec; 23(12):3007-15. PMID: 22989584; PMCID: PMC3888213.
  24. Raschle N, Zuk J, Ortiz-Mantilla S, Sliva DD, Franceschi A, Grant PE, Benasich AA, Gaab N. Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Ann N Y Acad Sci. 2012 Apr; 1252:43-50. PMID: 22524338; PMCID: PMC3499030.
  25. Raschle NM, Zuk J, Gaab N. Functional characteristics of developmental dyslexia in left-hemispheric posterior brain regions predate reading onset. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2156-61. PMID: 22308323; PMCID: PMC3277560.
  26. Benjamin CF, Gaab N. What's the story? The tale of reading fluency told at speed. Hum Brain Mapp. 2012 Nov; 33(11):2572-85. PMID: 21954000; PMCID: PMC3499039.
  27. Kovelman I, Norton ES, Christodoulou JA, Gaab N, Lieberman DA, Triantafyllou C, Wolf M, Whitfield-Gabrieli S, Gabrieli JD. Brain basis of phonological awareness for spoken language in children and its disruption in dyslexia. Cereb Cortex. 2012 Apr; 22(4):754-64. PMID: 21693783; PMCID: PMC4498147.
  28. You H, Gaab N, Wei N, Cheng-Lai A, Wang Z, Jian J, Song M, Meng X, Ding G. Neural deficits in second language reading: fMRI evidence from Chinese children with English reading impairment. Neuroimage. 2011 Aug 01; 57(3):760-70. PMID: 21146615; PMCID: PMC3499033.
  29. Benjamin C, Lieberman DA, Chang M, Ofen N, Whitfield-Gabrieli S, Gabrieli JD, Gaab N. The influence of rest period instructions on the default mode network. Front Hum Neurosci. 2010; 4:218. PMID: 21151779; PMCID: PMC2999982.
  30. Raschle NM, Chang M, Gaab N. Structural brain alterations associated with dyslexia predate reading onset. Neuroimage. 2011 Aug 01; 57(3):742-9. PMID: 20884362; PMCID: PMC3499031.
  31. Ghosh SS, Kakunoori S, Augustinack J, Nieto-Castanon A, Kovelman I, Gaab N, Christodoulou JA, Triantafyllou C, Gabrieli JD, Fischl B. Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age. Neuroimage. 2010 Oct 15; 53(1):85-93. PMID: 20621657; PMCID: PMC2914629.
  32. Schulze K, Gaab N, Schlaug G. Perceiving pitch absolutely: comparing absolute and relative pitch possessors in a pitch memory task. BMC Neurosci. 2009 Aug 27; 10:106. PMID: 19712445; PMCID: PMC2749857.
  33. Raschle NM, Lee M, Buechler R, Christodoulou JA, Chang M, Vakil M, Stering PL, Gaab N. Making MR imaging child's play - pediatric neuroimaging protocol, guidelines and procedure. J Vis Exp. 2009 Jul 30; (29). PMID: 19684560; PMCID: PMC3148936.
  34. Gaab N, Gabrieli JD, Glover GH. Resting in peace or noise: scanner background noise suppresses default-mode network. Hum Brain Mapp. 2008 Jul; 29(7):858-67. PMID: 18454447.
    View in: PubMed
  35. Christodoulou JA, Gaab N. Using and misusing neuroscience in education-related research. Cortex. 2009 Apr; 45(4):555-7. PMID: 18644589.
    View in: PubMed
  36. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise. Hum Brain Mapp. 2007 Aug; 28(8):703-20. PMID: 17080440.
    View in: PubMed
  37. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design. Hum Brain Mapp. 2007 Aug; 28(8):721-32. PMID: 17089376.
    View in: PubMed
  38. Gaab N, Gabrieli JD, Deutsch GK, Tallal P, Temple E. Neural correlates of rapid auditory processing are disrupted in children with developmental dyslexia and ameliorated with training: an fMRI study. Restor Neurol Neurosci. 2007; 25(3-4):295-310. PMID: 17943007.
    View in: PubMed
  39. Gaab N, Schulze K, Ozdemir E, Schlaug G. Neural correlates of absolute pitch differ between blind and sighted musicians. Neuroreport. 2006 Dec 18; 17(18):1853-7. PMID: 17179857.
    View in: PubMed
  40. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp. 2006 Aug; 27(8):662-77. PMID: 16317710.
    View in: PubMed
  41. Tallal P, Gaab N. Dynamic auditory processing, musical experience and language development. Trends Neurosci. 2006 Jul; 29(7):382-90. PMID: 16806512.
    View in: PubMed
  42. Gaab N, Gaser C, Schlaug G. Improvement-related functional plasticity following pitch memory training. Neuroimage. 2006 May 15; 31(1):255-63. PMID: 16427320.
    View in: PubMed
  43. Gaab N, Tallal P, Kim H, Lakshminarayanan K, Archie JJ, Glover GH, Gabrieli JD. Neural correlates of rapid spectrotemporal processing in musicians and nonmusicians. Ann N Y Acad Sci. 2005 Dec; 1060:82-8. PMID: 16597753.
    View in: PubMed
  44. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage. 2006 Apr 01; 30(2):588-600. PMID: 16275018.
    View in: PubMed
  45. Walker MP, Stickgold R, Alsop D, Gaab N, Schlaug G. Sleep-dependent motor memory plasticity in the human brain. Neuroscience. 2005; 133(4):911-7. PMID: 15964485.
    View in: PubMed
  46. Overy K, Norton AC, Cronin KT, Gaab N, Alsop DC, Winner E, Schlaug G. Imaging melody and rhythm processing in young children. Neuroreport. 2004 Aug 06; 15(11):1723-6. PMID: 15257135.
    View in: PubMed
  47. Gaab N, Paetzold M, Becker M, Walker MP, Schlaug G. The influence of sleep on auditory learning: a behavioral study. Neuroreport. 2004 Mar 22; 15(4):731-4. PMID: 15094486.
    View in: PubMed
  48. Gaab N, Schlaug G. The effect of musicianship on pitch memory in performance matched groups. Neuroreport. 2003 Dec 19; 14(18):2291-5. PMID: 14663178.
    View in: PubMed
  49. Gaab N, Schlaug G. Musicians differ from nonmusicians in brain activation despite performance matching. Ann N Y Acad Sci. 2003 Nov; 999:385-8. PMID: 14681161.
    View in: PubMed
  50. Hutchinson S, Lee LH, Gaab N, Schlaug G. Cerebellar volume of musicians. Cereb Cortex. 2003 Sep; 13(9):943-9. PMID: 12902393.
    View in: PubMed
  51. Gaab N, Keenan JP, Schlaug G. The effects of gender on the neural substrates of pitch memory. J Cogn Neurosci. 2003 Aug 15; 15(6):810-20. PMID: 14511534.
    View in: PubMed
  52. Gaab N, Gaser C, Zaehle T, Jancke L, Schlaug G. Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling. Neuroimage. 2003 Aug; 19(4):1417-26. PMID: 12948699.
    View in: PubMed
  53. Jäncke L, Gaab N, Wüstenberg T, Scheich H, Heinze HJ. Short-term functional plasticity in the human auditory cortex: an fMRI study. Brain Res Cogn Brain Res. 2001 Dec; 12(3):479-85. PMID: 11689309.
    View in: PubMed
  54. Ihl R, Grass-Kapanke B, Lahrem P, Brinkmeyer J, Fischer S, Gaab N, Kaupmannsennecke C. [Development and validation of a test for early diagnosis of dementia with differentiation from depression (TFDD)]. Fortschr Neurol Psychiatr. 2000 Sep; 68(9):413-22. PMID: 11037639.
    View in: PubMed
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