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Nadine Gaab, Ph.D.

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Overview
Our laboratory focuses on developmental cognitive neuroscience. We study cognitive processes such as auditory perception, language or reading and their neurological bases in the developing human brain. The majority of our studies involve functional magnetic resonance imaging (fMRI) but we also employ experimental behavioral studies and structural brain measurement techniques.
Our main research areas we investigate right now include:
-the neural correlates of reading and reading development (e.g.; does learning to read change your brain?)
-the relationship between auditory processing disorders and reading impairments
-the neural correlates of auditory and language processing in developmental dyslexia and specific language impairments
-the influence of musical training on language and reading development
-the development and evaluation of remediation programs for language and reading impairments
-the development of auditory and music processing and its relation to language development in typical reader

http://www.childrenshospital.org/research/gaablab

Mentoring
Available: 10/15/18, Expires: 12/31/19

This study aims to access possible neural pre-markers of developmental dyselxia in infancy and young childhood. We utilize brain imaging and behavioral testing and work closely with CHB families and local schools. The student will be involved in all aspects of a research study including data collection, test administration, assisting with pediatric imaging and analyses of MRI/fMRI and statistical data.

Available: 01/15/19, Expires: 01/15/20

This project aims to investigate possible neural pre-markers of developmental dyslexia using behavioral methods and functional magnetic resonance imaging fMRI). A student can be involved in all aspects including data collection and analysis.

Available: 09/25/18, Expires: 09/25/19

This study aims to validate stimuli/task design for an early developmental dyslexia/reading disability screening app. This study will assess the selected stimuli by relating it to the current best set of predictors which are all standardized ‘paper-pencil tests.’ The student will help prepare the testing materials for the validation and score reports of the participants' results, and have the opportunity to observe the administration of the paper and pencil tests. They will also be involved in recruitment of the families for the study and will work directly under the Research Assistant on the study.

Effects of home literacy environment on brain activity in children
Summer, 06/23/14 - 08/08/14
Neural Predictors of Developmental Dyslexia in Pre-Reading Children
Summer, 03/07/12 - 08/15/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AA023503 (JACOBSON, SANDRA W.) Aug 10, 2015 - Jul 31, 2020
    NIH/NIAAA
    Behavioral Characteristics and Neural Correlates of Reading Impairment in FASD
    Role: Principal Investigator
  2. R01HD065762 (GAAB, NADINE) Mar 15, 2011 - Jul 31, 2021
    NIH/NICHD
    Examining neural mechanisms of developmental dyslexia from infancy to school-age
    Role: Principal Investigator
  3. R01HD067312 (GABRIELI, JOHN) Jan 10, 2011 - Dec 31, 2015
    NIH/NICHD
    Using Cognitive Neuroscience to Predict Dyslexia among Kindergarden Children
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ozernov-Palchik O, Norton ES, Wang Y, Beach SD, Zuk J, Wolf M, Gabrieli JDE, Gaab N. The relationship between socioeconomic status and white matter microstructure in pre-reading children: A longitudinal investigation. Hum Brain Mapp. 2019 Feb 15; 40(3):741-754. PMID: 30276914.
    Citations:    Fields:    
  2. Zuk J, Perdue MV, Becker B, Yu X, Chang M, Raschle NM, Gaab N. Neural correlates of phonological processing: Disrupted in children with dyslexia and enhanced in musically trained children. Dev Cogn Neurosci. 2018 11; 34:82-91. PMID: 30103188.
    Citations:    Fields:    Translation:Humans
  3. Zuk J, Gaab N. Evaluating predisposition and training in shaping the musician's brain: the need for a developmental perspective. Ann N Y Acad Sci. 2018 May 24. PMID: 29799116.
    Citations:    Fields:    
  4. Yu X, Zuk J, Gaab N. What Factors Facilitate Resilience in Developmental Dyslexia? Examining Protective and Compensatory Mechanisms Across the Neurodevelopmental Trajectory. Child Dev Perspect. 2018 Dec; 12(4):240-246. PMID: 30510595.
    Citations:    
  5. Centanni TM, Norton ES, Park A, Beach SD, Halverson K, Ozernov-Palchik O, Gaab N, Gabrieli J. Early development of letter specialization in left fusiform is associated with better word reading and smaller fusiform face area. Dev Sci. 2018 09; 21(5):e12658. PMID: 29504651.
    Citations:    Fields:    
  6. Yu X, Raney T, Perdue MV, Zuk J, Ozernov-Palchik O, Becker BLC, Raschle NM, Gaab N. Emergence of the neural network underlying phonological processing from the prereading to the emergent reading stage: A longitudinal study. Hum Brain Mapp. 2018 05; 39(5):2047-2063. PMID: 29380469.
    Citations: 2     Fields:    
  7. Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLoS One. 2018; 13(1):e0191394. PMID: 29324890.
    Citations:    Fields:    
  8. Zuk J, Bishop-Liebler P, Ozernov-Palchik O, Moore E, Overy K, Welch G, Gaab N. Revisiting the "enigma" of musicians with dyslexia: Auditory sequencing and speech abilities. J Exp Psychol Gen. 2017 04; 146(4):495-511. PMID: 28383990.
    Citations:    Fields:    Translation:Humans
  9. Wang Y, Mauer MV, Raney T, Peysakhovich B, Becker BLC, Sliva DD, Gaab N. Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls. Cereb Cortex. 2017 04 01; 27(4):2469-2485. PMID: 27114172.
    Citations: 8     Fields:    Translation:Humans
  10. Langer N, Peysakhovich B, Zuk J, Drottar M, Sliva DD, Smith S, Becker BL, Grant PE, Gaab N. White Matter Alterations in Infants at Risk for Developmental Dyslexia. Cereb Cortex. 2017 02 01; 27(2):1027-1036. PMID: 26643353.
    Citations: 8     Fields:    Translation:Humans
  11. Raschle NM, Becker BLC, Smith S, Fehlbaum LV, Wang Y, Gaab N. Investigating the Influences of Language Delay and/or Familial Risk for Dyslexia on Brain Structure in 5-Year-Olds. Cereb Cortex. 2017 01 01; 27(1):764-776. PMID: 26585334.
    Citations: 8     Fields:    Translation:Humans
  12. Ozernov-Palchik O, Norton ES, Sideridis G, Beach SD, Wolf M, Gabrieli JDE, Gaab N. Longitudinal stability of pre-reading skill profiles of kindergarten children: implications for early screening and theories of reading. Dev Sci. 2017 09; 20(5). PMID: 27747988.
    Citations: 3     Fields:    Translation:Humans
  13. Powers SJ, Wang Y, Beach SD, Sideridis GD, Gaab N. Examining the relationship between home literacy environment and neural correlates of phonological processing in beginning readers with and without a familial risk for dyslexia: an fMRI study. Ann Dyslexia. 2016 10; 66(3):337-360. PMID: 27550556.
    Citations: 3     Fields:    Translation:Humans
  14. Saygin ZM, Osher DE, Norton ES, Youssoufian DA, Beach SD, Feather J, Gaab N, Gabrieli JD, Kanwisher N. Connectivity precedes function in the development of the visual word form area. Nat Neurosci. 2016 09; 19(9):1250-5. PMID: 27500407; PMCID: PMC5003691.
    Citations: 27     Fields:    Translation:Humans
  15. Ozernov-Palchik O, Yu X, Wang Y, Gaab N. Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice. Curr Opin Behav Sci. 2016 Aug; 10:45-58. PMID: 27766284.
    Citations:    
  16. Ozernov-Palchik O, Gaab N. Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexia. Wiley Interdiscip Rev Cogn Sci. 2016 Mar-Apr; 7(2):156-76. PMID: 26836227.
    Citations: 6     Fields:    Translation:HumansAnimals
  17. Zuk J, Benjamin C, Kenyon A, Gaab N. Correction: Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLoS One. 2015; 10(9):e0137930. PMID: 26332852; PMCID: PMC4558094.
    Citations: 2     Fields:    
  18. Paldino MJ, Hedges K, Gaab N, Galaburda AM, Grant PE. Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria. Behav Neurol. 2015; 2015:351391. PMID: 26180373; PMCID: PMC4477425.
    Citations:    Fields:    Translation:Humans
  19. Im K, Raschle NM, Smith SA, Ellen Grant P, Gaab N. Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners. Cereb Cortex. 2016 Mar; 26(3):1138-1148. PMID: 25576531; PMCID: PMC4757938.
    Citations: 13     Fields:    Translation:Humans
  20. Raschle NM, Smith SA, Zuk J, Dauvermann MR, Figuccio MJ, Gaab N. Investigating the neural correlates of voice versus speech-sound directed information in pre-school children. PLoS One. 2014; 9(12):e115549. PMID: 25532132; PMCID: PMC4274095.
    Citations: 1     Fields:    Translation:Humans
  21. Shetreet E, Chierchia G, Gaab N. Linguistic inability or poor performance: Dissociating scalar implicature generation and mismatch in the developing brain. Dev Psychol. 2014 Sep; 50(9):2264-75. PMID: 25046122.
    Citations:    Fields:    Translation:Humans
  22. Zuk J, Benjamin C, Kenyon A, Gaab N. Behavioral and neural correlates of executive functioning in musicians and non-musicians. PLoS One. 2014; 9(6):e99868. PMID: 24937544.
    Citations: 26     Fields:    Translation:Humans
  23. Langer N, Benjamin C, Minas J, Gaab N. The neural correlates of reading fluency deficits in children. Cereb Cortex. 2015 Jun; 25(6):1441-53. PMID: 24335032; PMCID: PMC4428293.
    Citations: 7     Fields:    Translation:Humans
  24. Zuk J, Ozernov-Palchik O, Kim H, Lakshminarayanan K, Gabrieli JD, Tallal P, Gaab N. Enhanced syllable discrimination thresholds in musicians. PLoS One. 2013; 8(12):e80546. PMID: 24339875.
    Citations: 12     Fields:    Translation:Humans
  25. Shetreet E, Chierchia G, Gaab N. When three is not some: on the pragmatics of numerals. J Cogn Neurosci. 2014 Apr; 26(4):854-63. PMID: 24168221.
    Citations:    Fields:    Translation:Humans
  26. Saygin ZM, Norton ES, Osher DE, Beach SD, Cyr AB, Ozernov-Palchik O, Yendiki A, Fischl B, Gaab N, Gabrieli JD. Tracking the roots of reading ability: white matter volume and integrity correlate with phonological awareness in prereading and early-reading kindergarten children. J Neurosci. 2013 Aug 14; 33(33):13251-8. PMID: 23946384.
    Citations: 37     Fields:    Translation:HumansCells
  27. Zuk J, Andrade PE, Andrade OV, Gardiner M, Gaab N. Musical, language, and reading abilities in early Portuguese readers. Front Psychol. 2013; 4:288. PMID: 23785339; PMCID: PMC3684766.
    Citations: 5     
  28. Raschle NM, Stering PL, Meissner SN, Gaab N. Altered neuronal response during rapid auditory processing and its relation to phonological processing in prereading children at familial risk for dyslexia. Cereb Cortex. 2014 Sep; 24(9):2489-501. PMID: 23599167; PMCID: PMC4184369.
    Citations: 15     Fields:    Translation:Humans
  29. Shetreet E, Chierchia G, Gaab N. When some is not every: dissociating scalar implicature generation and mismatch. Hum Brain Mapp. 2014 Apr; 35(4):1503-14. PMID: 23568365.
    Citations: 2     Fields:    Translation:Humans
  30. Im K, Pienaar R, Paldino MJ, Gaab N, Galaburda AM, Grant PE. Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex. 2013 Dec; 23(12):3007-15. PMID: 22989584; PMCID: PMC3888213.
    Citations: 10     Fields:    Translation:Humans
  31. Raschle N, Zuk J, Ortiz-Mantilla S, Sliva DD, Franceschi A, Grant PE, Benasich AA, Gaab N. Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Ann N Y Acad Sci. 2012 Apr; 1252:43-50. PMID: 22524338; PMCID: PMC3499030.
    Citations: 36     Fields:    Translation:Humans
  32. Raschle NM, Zuk J, Gaab N. Functional characteristics of developmental dyslexia in left-hemispheric posterior brain regions predate reading onset. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2156-61. PMID: 22308323; PMCID: PMC3277560.
    Citations: 33     Fields:    Translation:Humans
  33. Benjamin CF, Gaab N. What's the story? The tale of reading fluency told at speed. Hum Brain Mapp. 2012 Nov; 33(11):2572-85. PMID: 21954000.
    Citations: 8     Fields:    Translation:Humans
  34. Kovelman I, Norton ES, Christodoulou JA, Gaab N, Lieberman DA, Triantafyllou C, Wolf M, Whitfield-Gabrieli S, Gabrieli JD. Brain basis of phonological awareness for spoken language in children and its disruption in dyslexia. Cereb Cortex. 2012 Apr; 22(4):754-64. PMID: 21693783; PMCID: PMC4498147.
    Citations: 26     Fields:    Translation:Humans
  35. You H, Gaab N, Wei N, Cheng-Lai A, Wang Z, Jian J, Song M, Meng X, Ding G. Neural deficits in second language reading: fMRI evidence from Chinese children with English reading impairment. Neuroimage. 2011 Aug 01; 57(3):760-70. PMID: 21146615; PMCID: PMC3499033.
    Citations: 4     Fields:    Translation:Humans
  36. Benjamin C, Lieberman DA, Chang M, Ofen N, Whitfield-Gabrieli S, Gabrieli JD, Gaab N. The influence of rest period instructions on the default mode network. Front Hum Neurosci. 2010; 4:218. PMID: 21151779; PMCID: PMC2999982.
    Citations: 10     
  37. Raschle NM, Chang M, Gaab N. Structural brain alterations associated with dyslexia predate reading onset. Neuroimage. 2011 Aug 01; 57(3):742-9. PMID: 20884362; PMCID: PMC3499031.
    Citations: 48     Fields:    Translation:Humans
  38. Ghosh SS, Kakunoori S, Augustinack J, Nieto-Castanon A, Kovelman I, Gaab N, Christodoulou JA, Triantafyllou C, Gabrieli JD, Fischl B. Evaluating the validity of volume-based and surface-based brain image registration for developmental cognitive neuroscience studies in children 4 to 11 years of age. Neuroimage. 2010 Oct 15; 53(1):85-93. PMID: 20621657; PMCID: PMC2914629.
    Citations: 61     Fields:    Translation:Humans
  39. Schulze K, Gaab N, Schlaug G. Perceiving pitch absolutely: comparing absolute and relative pitch possessors in a pitch memory task. BMC Neurosci. 2009 Aug 27; 10:106. PMID: 19712445; PMCID: PMC2749857.
    Citations: 22     Fields:    Translation:Humans
  40. Raschle NM, Lee M, Buechler R, Christodoulou JA, Chang M, Vakil M, Stering PL, Gaab N. Making MR imaging child's play - pediatric neuroimaging protocol, guidelines and procedure. J Vis Exp. 2009 Jul 30; (29). PMID: 19684560; PMCID: PMC3148936.
    Citations: 33     Fields:    Translation:Humans
  41. Gaab N, Gabrieli JD, Glover GH. Resting in peace or noise: scanner background noise suppresses default-mode network. Hum Brain Mapp. 2008 Jul; 29(7):858-67. PMID: 18454447.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  42. Christodoulou JA, Gaab N. Using and misusing neuroscience in education-related research. Cortex. 2009 Apr; 45(4):555-7. PMID: 18644589.
    Citations: 2     Fields:    Translation:Humans
  43. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise. Hum Brain Mapp. 2007 Aug; 28(8):703-20. PMID: 17080440.
    Citations: 27     Fields:    Translation:HumansPHPublic Health
  44. Gaab N, Gabrieli JD, Glover GH. Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design. Hum Brain Mapp. 2007 Aug; 28(8):721-32. PMID: 17089376.
    Citations: 29     Fields:    Translation:HumansPHPublic Health
  45. Gaab N, Gabrieli JD, Deutsch GK, Tallal P, Temple E. Neural correlates of rapid auditory processing are disrupted in children with developmental dyslexia and ameliorated with training: an fMRI study. Restor Neurol Neurosci. 2007; 25(3-4):295-310. PMID: 17943007.
    Citations: 51     Fields:    Translation:Humans
  46. Gaab N, Schulze K, Ozdemir E, Schlaug G. Neural correlates of absolute pitch differ between blind and sighted musicians. Neuroreport. 2006 Dec 18; 17(18):1853-7. PMID: 17179857.
    Citations: 5     Fields:    Translation:Humans
  47. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp. 2006 Aug; 27(8):662-77. PMID: 16317710.
    Citations: 21     Fields:    Translation:Humans
  48. Tallal P, Gaab N. Dynamic auditory processing, musical experience and language development. Trends Neurosci. 2006 Jul; 29(7):382-390. PMID: 16806512.
    Citations: 54     Fields:    Translation:Humans
  49. Gaab N, Gaser C, Schlaug G. Improvement-related functional plasticity following pitch memory training. Neuroimage. 2006 May 15; 31(1):255-63. PMID: 16427320.
    Citations: 29     Fields:    Translation:Humans
  50. Gaab N, Tallal P, Kim H, Lakshminarayanan K, Archie JJ, Glover GH, Gabrieli JD. Neural correlates of rapid spectrotemporal processing in musicians and nonmusicians. Ann N Y Acad Sci. 2005 Dec; 1060:82-8. PMID: 16597753.
    Citations: 16     Fields:    Translation:HumansCells
  51. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage. 2006 Apr 01; 30(2):588-600. PMID: 16275018.
    Citations: 27     Fields:    Translation:Humans
  52. Walker MP, Stickgold R, Alsop D, Gaab N, Schlaug G. Sleep-dependent motor memory plasticity in the human brain. Neuroscience. 2005; 133(4):911-7. PMID: 15964485.
    Citations: 62     Fields:    Translation:Humans
  53. Overy K, Norton AC, Cronin KT, Gaab N, Alsop DC, Winner E, Schlaug G. Imaging melody and rhythm processing in young children. Neuroreport. 2004 Aug 06; 15(11):1723-6. PMID: 15257135.
    Citations: 7     Fields:    Translation:Humans
  54. Gaab N, Paetzold M, Becker M, Walker MP, Schlaug G. The influence of sleep on auditory learning: a behavioral study. Neuroreport. 2004 Mar 22; 15(4):731-4. PMID: 15094486.
    Citations: 15     Fields:    Translation:Humans
  55. Gaab N, Schlaug G. The effect of musicianship on pitch memory in performance matched groups. Neuroreport. 2003 Dec 19; 14(18):2291-5. PMID: 14663178.
    Citations: 21     Fields:    Translation:Humans
  56. Gaab N, Schlaug G. Musicians differ from nonmusicians in brain activation despite performance matching. Ann N Y Acad Sci. 2003 Nov; 999:385-8. PMID: 14681161.
    Citations: 13     Fields:    Translation:Humans
  57. Hutchinson S, Lee LH, Gaab N, Schlaug G. Cerebellar volume of musicians. Cereb Cortex. 2003 Sep; 13(9):943-9. PMID: 12902393.
    Citations: 64     Fields:    Translation:Humans
  58. Gaab N, Keenan JP, Schlaug G. The effects of gender on the neural substrates of pitch memory. J Cogn Neurosci. 2003 Aug 15; 15(6):810-20. PMID: 14511534.
    Citations: 7     Fields:    Translation:Humans
  59. Gaab N, Gaser C, Zaehle T, Jancke L, Schlaug G. Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling. Neuroimage. 2003 Aug; 19(4):1417-26. PMID: 12948699.
    Citations: 64     Fields:    Translation:Humans
  60. Jäncke L, Gaab N, Wüstenberg T, Scheich H, Heinze HJ. Short-term functional plasticity in the human auditory cortex: an fMRI study. Brain Res Cogn Brain Res. 2001 Dec; 12(3):479-85. PMID: 11689309.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  61. Ihl R, Grass-Kapanke B, Lahrem P, Brinkmeyer J, Fischer S, Gaab N, Kaupmannsennecke C. [Development and validation of a test for early diagnosis of dementia with differentiation from depression (TFDD)]. Fortschr Neurol Psychiatr. 2000 Sep; 68(9):413-22. PMID: 11037639.
    Citations: 13     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.