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Wenbin Ou, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhu C, Zhuang W, Chen L, Yang W, Ou WB. Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer. Transl Lung Cancer Res. 2020 Feb; 9(1):111-138. PMID: 32206559.
    Citations:    
  2. Huang M, Yang W, Zhu J, Mariño-Enríquez A, Zhu C, Chen J, Wu Y, Quan Y, Qiu H, Li X, Chai L, Fletcher JA, Ou WB. Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours. Br J Cancer. 2020 Feb; 122(3):372-381. PMID: 31776458.
    Citations:    
  3. Xu WF, Ma YC, Ma HS, Shi L, Mu H, Ou WB, Peng J, Li TT, Qin T, Zhou HM, Fu XQ, Li XH. Co-targeting CK2a and YBX1 suppresses tumor progression by coordinated inhibition of the PI3K/AKT signaling pathway. Cell Cycle. 2019 Dec; 18(24):3472-3490. PMID: 31713447.
    Citations:    
  4. Ou WB, Ni N, Zuo R, Zhuang W, Zhu M, Kyriazoglou A, Wu D, Eilers G, Demetri GD, Qiu H, Li B, Marino-Enriquez A, Fletcher JA. Cyclin D1 is a mediator of gastrointestinal stromal tumor KIT-independence. Oncogene. 2019 09; 38(39):6615-6629. PMID: 31371779.
    Citations:    
  5. Cao Z, Gao Q, Fu M, Ni N, Pei Y, Ou WB. Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives. Oncol Lett. 2019 Feb; 17(2):2020-2030. PMID: 30675269.
    Citations:    
  6. Tu Y, Zuo R, Ni N, Eilers G, Wu D, Pei Y, Nie Z, Wu Y, Wu Y, Ou WB. Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression. Cell Cycle. 2018; 17(23):2577-2592. PMID: 30488756.
    Citations:    
  7. Liu XL, Zuo R, Ou WB. The hippo pathway provides novel insights into lung cancer and mesothelioma treatment. J Cancer Res Clin Oncol. 2018 Nov; 144(11):2097-2106. PMID: 30073421.
    Citations:    
  8. Ke M, He Q, Hong D, Li O, Zhu M, Ou WB, He Y, Wu Y. Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/?Akt-dependent Tbx-3 activation pathway. Int J Mol Med. 2018 Jul; 42(1):131-140. PMID: 29620145.
    Citations:    
  9. Hong D, Ding J, Li O, He Q, Ke M, Zhu M, Liu L, Ou WB, He Y, Wu Y. Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection. Stem Cell Res Ther. 2018 02 26; 9(1):49. PMID: 29482598.
    Citations:    
  10. He Q, Huang S, Wu Y, Zhang W, Wang F, Cao J, Sheng Q, Liang Z, Liu L, Ou WB. Comparative study on the composition of free amino acids and derivatives in the two botanical origins of an edible Chinese herb "Xiebai", i.e., Allium chinense G. Don and Allium macrostemon Bunge species. Food Res Int. 2018 04; 106:446-457. PMID: 29579946.
    Citations:    
  11. Chen W, Kuang Y, Qiu HB, Cao Z, Tu Y, Sheng Q, Eilers G, He Q, Li HL, Zhu M, Wang Y, Zhang R, Wu Y, Meng F, Fletcher JA, Ou WB. Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors. Cancer Res. 2017 09 15; 77(18):5107-5117. PMID: 28760855.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Lee JC, Li CF, Huang HY, Zhu MJ, Mariño-Enríquez A, Lee CT, Ou WB, Hornick JL, Fletcher JA. ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma. J Pathol. 2017 Feb; 241(3):316-323. PMID: 27874193.
    Citations: 8     Fields:    Translation:HumansCells
  13. Yong KJ, Li A, Ou WB, Hong CK, Zhao W, Wang F, Tatetsu H, Yan B, Qi L, Fletcher JA, Yang H, Soo R, Tenen DG, Chai L. Targeting SALL4 by entinostat in lung cancer. Oncotarget. 2016 Nov 15; 7(46):75425-75440. PMID: 27705911.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Ou WB, Lu M, Eilers G, Li H, Ding J, Meng X, Wu Y, He Q, Sheng Q, Zhou HM, Fletcher JA. Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53. Br J Cancer. 2016 Nov 08; 115(10):1253-1263. PMID: 27736841.
    Citations: 5     Fields:    Translation:HumansCells
  15. Yang P, Chen W, Li X, Eilers G, He Q, Liu L, Wu Y, Wu Y, Yu W, Fletcher JA, Ou WB. Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3. Oncotarget. 2016 May 31; 7(22):32652-63. PMID: 27129163.
    Citations: 3     Fields:    Translation:HumansCells
  16. Wu Y, Shu J, He C, Li M, Wang Y, Ou W, He Y. ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3. Theriogenology. 2016 Jan 15; 85(2):302-14. PMID: 26476594.
    Citations:    
  17. Ou WB, Zhu J, Eilers G, Li X, Kuang Y, Liu L, Mariño-Enríquez A, Yan Z, Li H, Meng F, Zhou H, Sheng Q, Fletcher JA. HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status. Oncotarget. 2015 Apr 30; 6(12):10510-20. PMID: 25888633.
    Citations: 10     Fields:    Translation:HumansCells
  18. Shen B, Liu HC, Ou WB, Eilers G, Zhou SM, Meng FG, Li CQ, Li YQ. Toxicity induced by Basic Violet 14, Direct Red 28 and Acid Red 26 in zebrafish larvae. J Appl Toxicol. 2015 Dec; 35(12):1473-80. PMID: 25727789.
    Citations:    
  19. Zhao W, Wang Z, Cai Q, Ou WB, Meng FG. [Detection of biohazardous materials in water upon the characteristics of fluorescent sensor Frex]. Huan Jing Ke Xue. 2014 Jun; 35(6):2287-93. PMID: 25158508.
    Citations:    
  20. Zhou S, Liu L, Li H, Eilers G, Kuang Y, Shi S, Yan Z, Li X, Corson JM, Meng F, Zhou H, Sheng Q, Fletcher JA, Ou WB. Multipoint targeting of the PI3K/mTOR pathway in mesothelioma. Br J Cancer. 2014 May 13; 110(10):2479-88. PMID: 24762959.
    Citations: 16     Fields:    Translation:HumansCells
  21. Mariño-Enríquez A, Ou WB, Cowley G, Luo B, Jonker AH, Mayeda M, Okamoto M, Eilers G, Czaplinski JT, Sicinska E, Wang Y, Taguchi T, Demetri GD, Root DE, Fletcher JA. Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors. Oncogene. 2014 Apr 03; 33(14):1872-6. PMID: 23584476.
    Citations: 11     Fields:    Translation:HumansCells
  22. Li XH, Chen XJ, Ou WB, Zhang Q, Lv ZR, Zhan Y, Ma L, Huang T, Yan YB, Zhou HM. Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis. Int J Biochem Cell Biol. 2013 May; 45(5):979-86. PMID: 23416112.
    Citations:    
  23. Lee CH, Mariño-Enriquez A, Ou W, Zhu M, Ali RH, Chiang S, Amant F, Gilks CB, van de Rijn M, Oliva E, Debiec-Rychter M, Dal Cin P, Fletcher JA, Nucci MR. The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. Am J Surg Pathol. 2012 May; 36(5):641-53. PMID: 22456610.
    Citations: 25     Fields:    Translation:Humans
  24. Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):929-34. PMID: 22223660.
    Citations: 45     Fields:    Translation:HumansCells
  25. Jiao Y, Ou W, Meng F, Zhou H, Wang A. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation. Mol Cancer. 2011 Sep 30; 10:125. PMID: 21962244.
    Citations:    
  26. Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT. Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16386-91. PMID: 21930930.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  27. Ou WB, Yi T, Kim JM, Khorana HG. The roles of transmembrane domain helix-III during rhodopsin photoactivation. PLoS One. 2011 Feb 25; 6(2):e17398. PMID: 21364764.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Ou WB, Hubert C, Corson JM, Bueno R, Flynn DL, Sugarbaker DJ, Fletcher JA. Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma. Neoplasia. 2011 Jan; 13(1):12-22. PMID: 21245936.
    Citations: 22     Fields:    Translation:HumansCells
  29. Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR. ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. Genes Chromosomes Cancer. 2011 Mar; 50(3):146-53. PMID: 21213368.
    Citations: 29     Fields:    Translation:Humans
  30. Ou WB, Corson JM, Flynn DL, Lu WP, Wise SC, Bueno R, Sugarbaker DJ, Fletcher JA. AXL regulates mesothelioma proliferation and invasiveness. Oncogene. 2011 Apr 07; 30(14):1643-52. PMID: 21132014.
    Citations: 26     Fields:    Translation:HumansCells
  31. Parkkila S, Lasota J, Fletcher JA, Ou WB, Kivelä AJ, Nuorva K, Parkkila AK, Ollikainen J, Sly WS, Waheed A, Pastorekova S, Pastorek J, Isola J, Miettinen M. Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors. Mod Pathol. 2010 May; 23(5):743-50. PMID: 20081808.
    Citations: 22     Fields:    Translation:Humans
  32. Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, Town A, McKinley A, Ou WB, Fletcher JA, Fletcher CD, Huang X, Cohen DP, Baum CM, Demetri GD. Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J Clin Oncol. 2008 Nov 20; 26(33):5352-9. PMID: 18955458.
    Citations: 161     Fields:    Translation:HumansCellsCTClinical Trials
  33. Ou WB, Zhu MJ, Demetri GD, Fletcher CD, Fletcher JA. Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. Oncogene. 2008 Sep 18; 27(42):5624-34. PMID: 18521081.
    Citations: 26     Fields:    Translation:HumansCells
  34. Zhu MJ, Ou WB, Fletcher CD, Cohen PS, Demetri GD, Fletcher JA. KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance. Oncogene. 2007 Sep 27; 26(44):6386-95. PMID: 17452978.
    Citations: 15     Fields:    Translation:HumansCells
  35. Heinrich MC, Corless CL, Blanke CD, Demetri GD, Joensuu H, Roberts PJ, Eisenberg BL, von Mehren M, Fletcher CD, Sandau K, McDougall K, Ou WB, Chen CJ, Fletcher JA. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol. 2006 Oct 10; 24(29):4764-74. PMID: 16954519.
    Citations: 216     Fields:    Translation:HumansCTClinical Trials
  36. Rossi S, Ou W, Tang D, Bhattacharya N, Dei Tos AP, Fletcher JA, Loda M. Gastrointestinal stromal tumours overexpress fatty acid synthase. J Pathol. 2006 Jul; 209(3):369-75. PMID: 16583360.
    Citations: 17     Fields:    Translation:HumansCells
  37. Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB, Zhou HM. Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. J Biol Chem. 2005 Apr 08; 280(14):13470-6. PMID: 15695804.
    Citations:    
  38. Subramanian S, West RB, Corless CL, Ou W, Rubin BP, Chu KM, Leung SY, Yuen ST, Zhu S, Hernandez-Boussard T, Montgomery K, Nielsen TO, Patel RM, Goldblum JR, Heinrich MC, Fletcher JA, van de Rijn M. Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene. 2004 Oct 14; 23(47):7780-90. PMID: 15326474.
    Citations: 34     Fields:    Translation:HumansCells
  39. Ou WB, Wang RS, Lu J, Zhou HM. Effects of arginine on rabbit muscle creatine kinase and salt-induced molten globule-like state. Biochim Biophys Acta. 2003 Nov 03; 1652(1):7-16. PMID: 14580992.
    Citations:    
  40. Tang HM, Ou WB, Zhou HM. Effects of lactic acid and NaCl on creatine kinase from rabbit muscle. Biochem Cell Biol. 2003 Feb; 81(1):1-7. PMID: 12683630.
    Citations:    
  41. Ou Wb, Wang RS, Lu J, Zhou HM. Effects of aspartate on rabbit muscle creatine kinase and the salt induced molten globule state. Int J Biochem Cell Biol. 2002 Aug; 34(8):970-82. PMID: 12007635.
    Citations:    
  42. Wang F, Ou WB, Li S, Zhou HM. Effect of hydrogen peroxide on the activity and structure of Escherichia coli chaperone GroEL. Biochemistry (Mosc). 2002 May; 67(5):547-52. PMID: 12059774.
    Citations:    
  43. Ou WB, Park YD, Zhou HM. Effect of osmolytes as folding aids on creatine kinase refolding pathway. Int J Biochem Cell Biol. 2002 Feb; 34(2):136-47. PMID: 11809416.
    Citations:    
  44. Ou WB, Wang RS, Zhou HM. Conformational changes and inactivation of rabbit muscle creatine kinase in dimethyl sulfoxide solutions. Biochem Cell Biol. 2002; 80(4):427-34. PMID: 12234096.
    Citations:    
  45. Ou WB, Park YD, Zhou HM. Molecular mechanism for osmolyte protection of creatine kinase against guanidine denaturation. Eur J Biochem. 2001 Nov; 268(22):5901-11. PMID: 11722578.
    Citations:    
  46. Ou WB, Luo W, Park YD, Zhou HM. Chaperone-like activity of peptidyl-prolyl cis-trans isomerase during creatine kinase refolding. Protein Sci. 2001 Nov; 10(11):2346-53. PMID: 11604540.
    Citations:    
  47. Park YD, Ou WB, Yu TW, Zhou HM. Folding pathway for partially folded rabbit muscle creatine kinase. Biochem Cell Biol. 2001; 79(4):479-87. PMID: 11527217.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.