Harvard Catalyst Profiles

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Laura E. Fredenburgh, M.D.,C.M.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL137366 (FREDENBURGH, LAURA ELIZABETH) Jan 1, 2018 - Dec 31, 2021
    NIH/NHLBI
    Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension
    Role: Principal Investigator
  2. R01HL114839 (FREDENBURGH, LAURA ELIZABETH) Aug 14, 2012 - Jun 30, 2017
    NIH/NHLBI
    Mechanobiology of Vascular Remodeling in Pulmonary Arterial Hypertension
    Role: Principal Investigator
  3. R03HL115106 (FREDENBURGH, LAURA ELIZABETH) Aug 1, 2012 - Jun 30, 2014
    NIH/NHLBI
    Arterial Stiffness in the Pathogenesis of Human Pulmonary Arterial Hypertension
    Role: Principal Investigator
  4. K08GM083207 (FREDENBURGH, LAURA ELIZABETH) Dec 11, 2007 - May 30, 2013
    NIH/NIGMS
    Role of Cyclooxygenase-2-derived Prostanoids in Polymicrobial Sepsis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Englert JA, Cho MH, Lamb AE, Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, Vera MP, Dieffenbach PB, Fredenburgh LE, Kang JB, Bhatt AS, Antin JH, Ho VT, Soiffer RJ, Howrylak JA, Himes BE, Baron RM. Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation. Respir Res. 2019 Jan 21; 20(1):15. PMID: 30665420.
    Citations:    Fields:    
  2. Johansson PI, Nakahira K, Rogers AJ, McGeachie MJ, Baron RM, Fredenburgh LE, Harrington J, Choi AMK, Christopher KB. Plasma mitochondrial DNA and metabolomic alterations in severe critical illness. Crit Care. 2018 12 29; 22(1):360. PMID: 30594224.
    Citations:    Fields:    
  3. Lee H, Groot M, Pinilla-Vera M, Fredenburgh LE, Jin Y. Identification of miRNA-rich vesicles in bronchoalveolar lavage fluid: Insights into the function and heterogeneity of extracellular vesicles. J Control Release. 2019 Jan 28; 294:43-52. PMID: 30529727.
    Citations:    Fields:    
  4. Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 Dec 06; 3(23). PMID: 30518685.
    Citations:    Fields:    
  5. Kuethe DO, Hix JM, Fredenburgh LE. T1 , T1 contrast, and Ernst-angle images of four rat-lung pathologies. Magn Reson Med. 2019 Apr; 81(4):2489-2500. PMID: 30417929.
    Citations:    Fields:    
  6. Dieffenbach PB, Maracle M, Tschumperlin DJ, Fredenburgh LE. Mechanobiological Feedback in Pulmonary Vascular Disease. Front Physiol. 2018; 9:951. PMID: 30090065.
    Citations:    
  7. Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelzstein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM. Circulating RIPK3 levels are associated with mortality and organ failure during critical illness. JCI Insight. 2018 Jul 12; 3(13). PMID: 29997296.
    Citations:    Fields:    
  8. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 Jun 13; 10(445). PMID: 29899023.
    Citations:    
  9. Siempos II, Ma KC, Imamura M, Baron RM, Fredenburgh LE, Huh JW, Moon JS, Finkelsztein EJ, Jones DS, Lizardi MT, Schenck EJ, Ryter SW, Nakahira K, Choi AM. RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury. JCI Insight. 2018 May 03; 3(9). PMID: 29720570.
    Citations: 1     Fields:    
  10. Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ. Aging and anatomical variations in lung tissue stiffness. Am J Physiol Lung Cell Mol Physiol. 2018 Jun 01; 314(6):L946-L955. PMID: 29469613.
    Citations: 3     Fields:    
  11. Abdulnour RE, Howrylak JA, Tavares AH, Douda DN, Henkels KM, Miller TE, Fredenburgh LE, Baron RM, Gomez-Cambronero J, Levy BD. Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury. J Leukoc Biol. 2018 05; 103(5):919-932. PMID: 29437245.
    Citations:    Fields:    
  12. Park J, Pabon M, Choi AMK, Siempos II, Fredenburgh LE, Baron RM, Jeon K, Chung CR, Yang JH, Park CM, Suh GY. Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts. BMC Pulm Med. 2017 Dec 15; 17(1):204. PMID: 29246207.
    Citations: 1     Fields:    Translation:Humans
  13. Lasky-Su J, Dahlin A, Litonjua AA, Rogers AJ, McGeachie MJ, Baron RM, Gazourian L, Barragan-Bradford D, Fredenburgh LE, Choi AMK, Mogensen KM, Quraishi SA, Amrein K, Christopher KB. Metabolome alterations in severe critical illness and vitamin D status. Crit Care. 2017 07 28; 21(1):193. PMID: 28750641.
    Citations: 1     Fields:    Translation:Humans
  14. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L628-L647. PMID: 28642262.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Sicard D, Fredenburgh LE, Tschumperlin DJ. Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions. J Mech Behav Biomed Mater. 2017 10; 74:118-127. PMID: 28595103.
    Citations: 3     Fields:    Translation:Humans
  16. Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA. Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. Am J Respir Cell Mol Biol. 2017 03; 56(3):300-309. PMID: 27636016.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, Hatabu H, Nishino M, Padera RF, Fredenburgh LE, Baron RM, Englert JA. Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 01 01; 195(1):138-141. PMID: 28035861.
    Citations:    Fields:    Translation:Humans
  18. Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA. Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245. PMID: 27513357.
    Citations: 10     Fields:    Translation:Animals
  19. Mogensen KM, Lasky-Su J, Rogers AJ, Baron RM, Fredenburgh LE, Rawn J, Robinson MK, Massarro A, Choi AM, Christopher KB. Metabolites Associated With Malnutrition in the Intensive Care Unit Are Also Associated With 28-Day Mortality. JPEN J Parenter Enteral Nutr. 2017 02; 41(2):188-197. PMID: 27406941.
    Citations: 2     Fields:    Translation:Humans
  20. Kuethe DO, Filipczak PT, Hix JM, Gigliotti AP, Estépar RS, Washko GR, Baron RM, Fredenburgh LE. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 08 01; 311(2):L208-18. PMID: 27288491.
    Citations: 3     Fields:    Translation:Animals
  21. Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinkovic A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE. Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight. 2016 Jun 02; 1(8). PMID: 27347562.
    Citations: 11     Fields:    
  22. Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ. Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures. Cardiovasc Toxicol. 2016 Apr; 16(2):163-71. PMID: 25900702; PMCID: PMC4618267.
    Citations: 7     Fields:    Translation:AnimalsPHPublic Health
  23. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. PMID: 26565914; PMCID: PMC4644508.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  24. Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN. The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):314-25. PMID: 25568926.
    Citations: 8     Fields:    Translation:AnimalsCells
  25. Fredenburgh LE, Kraft BD, Hess DR, Harris RS, Wolf MA, Suliman HB, Roggli VL, Davies JD, Winkler T, Stenzler A, Baron RM, Thompson BT, Choi AM, Welty-Wolf KE, Piantadosi CA. Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15; 309(8):L834-46. PMID: 26320156.
    Citations: 6     Fields:    Translation:HumansAnimals
  26. Englert JA, Macias AA, Amador-Munoz D, Pinilla Vera M, Isabelle C, Guan J, Magaoay B, Suarez Velandia M, Coronata A, Lee A, Fredenburgh LE, Culley DJ, Crosby G, Baron RM. Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology. 2015 Aug; 123(2):377-88. PMID: 26068207; PMCID: PMC4510009.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Filipczak PT, Senft AP, Seagrave J, Weber W, Kuehl PJ, Fredenburgh LE, McDonald JD, Baron RM. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury. Toxicol Sci. 2015 Jul; 146(1):89-100. PMID: 25870319; PMCID: PMC4476462.
    Citations: 3     Fields:    Translation:Animals
  28. Fredenburgh LE, Merz AA, Cheng S. Haeme oxygenase signalling pathway: implications for cardiovascular disease. Eur Heart J. 2015 Jun 21; 36(24):1512-8. PMID: 25827602; PMCID: PMC4475572.
    Citations: 9     Fields:    Translation:HumansCells
  29. Liu F, Lagares D, Choi KM, Stopfer L, Marinkovic A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15; 308(4):L344-57. PMID: 25502501; PMCID: PMC4329470.
    Citations: 75     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  30. Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm reprogramming during lung inflammation. Nat Commun. 2014 Sep 11; 5:4753. PMID: 25208554; PMCID: PMC4162491.
    Citations: 24     Fields:    Translation:AnimalsCells
  31. Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS. Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):445-55. PMID: 25054455; PMCID: PMC4214130.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  32. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538. PMID: 24498130; PMCID: PMC3907548.
    Citations: 28     Fields:    Translation:Humans
  33. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577; discussion e1001577. PMID: 24391478; PMCID: PMC3876981.
    Citations: 75     Fields:    Translation:Humans
  34. Lee S, Lee SJ, Coronata AA, Fredenburgh LE, Chung SW, Perrella MA, Nakahira K, Ryter SW, Choi AM. Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxid Redox Signal. 2014 Jan 20; 20(3):432-42. PMID: 23971531; PMCID: PMC3894711.
    Citations: 31     Fields:    Translation:HumansAnimals
  35. Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013 Jul 24; 5(195):195ra95. PMID: 23884467; PMCID: PMC3924586.
    Citations: 92     Fields:    Translation:Humans
  36. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1225-34. PMID: 22461369.
    Citations: 102     Fields:    Translation:HumansAnimals
  37. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L829-37. PMID: 22328358.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  38. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67. PMID: 21967897; PMCID: PMC3208135.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  39. Fredenburgh LE, Ma J, Perrella MA. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009 Feb; 19(2):31-7. PMID: 19577709; PMCID: PMC2746907.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  40. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35. PMID: 19097991; PMCID: PMC2715902.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  41. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22. PMID: 18391113; PMCID: PMC2586933.
    Citations: 26     Fields:    Translation:AnimalsCells
  42. Fredenburgh LE, Campion EW, Drazen JM. Clinical Decisions. Mild persistent asthma--polling results. N Engl J Med. 2007 Jul 12; 357(2):179-80. PMID: 17582063.
    Citations: 1     Fields:    Translation:Humans
  43. Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65. PMID: 16980551; PMCID: PMC2176110.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  44. Fredenburgh LE, Liang OD, Macias, AA, Mitsialis SA, Kourembanas S, Perrella MA. Exacerbation of Hypoxia-Induced Pulmonary Hypertension and Vascular Remodeling in COX-2 deficient mice. Proc Am Thorac Soc. 2006; 3:A278.
  45. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of Heme Oxygenase-1 Expression in the Lung Parenchyma Exacerbates Endotoxin-Induced Acute Lung Injury. Proc Am Thorac Soc. 2006; 3:A571.
  46. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 03; 51(5):513-20. PMID: 16309574.
    Citations: 12     Fields:    Translation:Animals
  47. Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol. 2005 Apr 15; 174(8):5033-9. PMID: 15814734.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  48. Baron RM, Fredenburgh LE, Macias AA, Okabe RO, Layne MD, Perrella MA. Reduction of Nitric Oxide Synthase 2 Expression by Minor Groove Binding Agents Improves Survival from Endotoxemia. Proc Am Thorac Soc. 2005; 2:A.
  49. Fredenburgh LE, Ejima K, Baron RM, Chung SW, Layne MD, Perrella MA. Enhanced COX-2 Expression in HO-1 Null Mice Contributes to Endotoxemic Lung Injury. Proc Am Thorac Soc. 2005; 2: A152. 2005; 2:A152.
  50. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53. PMID: 15356165.
    Citations: 9     Fields:    Translation:AnimalsCells
  51. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8. PMID: 15208261.
    Citations: 15     Fields:    Translation:AnimalsCells
  52. Fredenburgh LE, Ejima K, Liu X, Baron RM, and Perrella MA. Attenuation of Hypotension in COX-2 Null Mice Contributes to Improved Outcome In Endotoxemia. Am J Resp Crit Care Med. 2004; 169(7):A636.
  53. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, DeSanctis GT, Ingenito EP, Perrella MA. Nitric Oxide Synthase-2 Mediates Acute Lung Injury in Mice through Decreased Surfactant Protein-B Expression. Am J Resp Crit Care Med. 2004; 169(7):A264.
  54. Chung SW, Chen Y-H, Fredenburgh LE, Layne MD, Yet S-F, Perrella MA. Ets2 Enhances Heme Oxygenase-1 Gene Expression through an Akt-independent Phosphoinositide 3 (PI3)-Kinase Pathway. Am J Resp Crit Care Med. 2004; 169(7169):A423.
  55. Baron RM, Carvajal IM, Fredenburgh LE, Porrata Y, Haley K, Sonna LA, Layne MD, Yet S-F, Ingenito EP, Perrella MA . Nitric Oxide Synthase 2 Mediates Acute Lung Injury in Mice Through Decreased Surfactant Protein B Expression. Circulation. 2003; 108:269.
  56. Mallory FB, Mallory CW, Butler KE, Lewis MB, Xia AQ, Luzik ED, Fredenburgh LE, Ramanjulu MM, Van QN, Francl MM, Freed DA, Wray CC, Hann C, Nerz-Stormes M, Carroll PJ, Chirlian LE. Nuclear Spin-Spin Coupling via Nonbonded Interactions. 8. The Distance Dependence of Through-Space Fluorine-Fluorine Coupling. Journal of the American Chemical Society. 2000; 122:4108-4116.
  57. Fredenburgh LE, Dougherty G . Potential Impact of Once-A-Day Ceftriaxone on Reducing Inappropriate Hospitalization for Pediatric Cellulitis. Archives of Pediatrics and Adolescent Medicine. 1996; 150(Supp):76.
  58. Senanayake CH, Smith GB, Ryan KM, Fredenburgh LE, Liu J, Roberts FE, Hughes DL, Larsen RD, Verhoeven TR, Reider PJ. . . 1996; 37: 3271-3274. The Role of 4-(3-Phenylpropyl)pyridine N-oxide (P3NO) in the Manganese-Salen-Catalyzed Asymmetric Epoxidation of Indene. Tetrahedron Letters. 1996; 37:3271-3274.
  59. Senanayake CH, Fredenburgh LE, Reamer RA, Liu J, Roberts FE, Humphrey G, Thompson AS, Larsen RD, Verhoeven TR, Reider PJ, Shinkai I. New Approach to the Imidazolutidine Moiety of MK-996. Heterocycles. 1996; 42:821-830.
  60. Fredenburgh LE, Larsen RD, Liu J, Reamer RA, Senanayake CH, Verhoeven TR. Process for the Preparation of Imidazolutidine. 1995.
  61. Senanayake CH, DiMichele LM, Liu J, Fredenburgh LE, Ryan KM, Roberts FE, Larsen RD, Verhoeven TR, Reider PJ. Regio- and Stereocontrolled Syntheses of Cyclic Chiral cis-Amino Alcohols from 1,2-Diols or Epoxides. Tetrahedron Letters. 1995; 36:7615-7618.
  62. Senanayake CH, Roberts FE, DiMichele LM, Ryan KM, Liu J, Fredenburgh LE, Foster BS, Douglas AW, Larsen RD, Verhoeven TR, Reider PJ. The Behavior of Indene Oxide in the Ritter Reaction: A Simple Route to cis-Aminoindanol. Tetrahedron Letters. 1995; 36:3993-3996.
  63. Senanayake CH, Fredenburgh LE, Reamer RA, Larsen RD, Verhoeven TR, Reider PJ. Nature of N-Bromosuccinimide in Basic Media: The True Oxidizing Species in the Hofmann Rearrangement. Journal of the American Chemical Society. 1994; 116:7947-7948.
  64. Senanayake CH, Fredenburgh LE, Reamer RA, Liu J, Larsen RD, Verhoeven TR, Reider PJ. Magnesium-Assisted Imidazole Formation from Unreactive Ureas. Tetrahedron Letters. 1994; 35:5775-5778.
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Physical Neighbors
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.