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Irit Adini, Ph.D.


Available: 01/01/23, Expires: 12/31/23

My primary area of research is the correlation between pigment production and immune responses. Specifically, our lab seeks to understand the mechanisms underlying dendritic cell subsets and maturation in response to pigment production by melanocytes, with a strong emphasis on identifying new targets and developing novel treatments for autoimmunity diseases associated with racial disparity, such as Atopic dermatitis and Lupus. As a student working in my lab, I expect the student to take an active role in running in vivo and in vitro experiments. In addition to leading a small project, the student will participate in a future manuscript that will be published following his/her contribution.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Halasi M, Grinstein M, Adini A, Adini I. Fibromodulin Ablation Exacerbates the Severity of Acute Colitis. J Inflamm Res. 2022; 15:4515-4526. PMID: 35966006; PMCID: PMC9374093.
  2. Zveik O, Rechtman A, Haham N, Adini I, Canello T, Lavon I, Brill L, Vaknin-Dembinsky A. Sera of Neuromyelitis Optica Patients Increase BID-Mediated Apoptosis in Astrocytes. Int J Mol Sci. 2022 Jun 27; 23(13). PMID: 35806122; PMCID: PMC9266359.
    Citations:    Fields:    Translation:HumansCells
  3. Halasi M, Nyska A, Rubin L, Tal Y, Tsokos GC, Adini I. Melanocyte-secreted fibromodulin constrains skin inflammation in mice injected with lupus serum. Clin Immunol. 2022 08; 241:109055. PMID: 35640789.
    Citations:    Fields:    
  4. Wu Y, Zheng Z, Cao X, Yang Q, Norton V, Adini A, Maiti AK, Adini I, Wu H. RIP1/RIP3/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis. Front Cardiovasc Med. 2021; 8:696362. PMID: 34497836.
    Citations: 3     
  5. Freilikhman S, Halasi M, Eran A, Adini I. Melanocytes determine angiogenesis gene expression across human tissues. PLoS One. 2021; 16(5):e0251121. PMID: 33983985; PMCID: PMC8118295.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Adini A, Adini I, Grad E, Tal Y, Danenberg HD, Kang PM, Matthews BD, D'Amato RJ. The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia. Int J Mol Sci. 2021 May 13; 22(10). PMID: 34068392.
    Citations:    Fields:    Translation:AnimalsCells
  7. Tal Y, Adini A, Eran A, Adini I. Racial disparity in Covid-19 mortality rates - A plausible explanation. Clin Immunol. 2020 08; 217:108481. PMID: 32473354; PMCID: PMC7253967.
    Citations: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  8. Adini A, Adini I, Chi ZL, Derda R, Birsner AE, Matthews BD, D'Amato RJ. A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P. Angiogenesis. 2017 Aug; 20(3):399-408. PMID: 28397127.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  9. Mucka P, Levonyak N, Geretti E, Zwaans BMM, Li X, Adini I, Klagsbrun M, Adam RM, Bielenberg DR. Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency. Am J Pathol. 2016 11; 186(11):2803-2812. PMID: 27751443; PMCID: PMC5222969.
    Citations: 13     Fields:    Translation:HumansAnimals
  10. Adini I, Ghosh K. Mouse Retinal Whole Mounts and Quantification of Vasculature Protocol. Bio Protoc. 2015 Aug 05; 5(15). PMID: 29552585; PMCID: PMC5856157.
    Citations: 2     
  11. Abramov E, Cassiola F, Schwob O, Karsh-Bluman A, Shapero M, Ellis J, Luyindula D, Adini I, D'Amato RJ, Benny O. Cellular mechanism of oral absorption of solidified polymer micelles. Nanomedicine. 2015 Nov; 11(8):1993-2002. PMID: 26247432.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Adini I, Adini A, Bazinet L, Watnick RS, Bielenberg DR, D'Amato RJ. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J. 2015 Feb; 29(2):662-70. PMID: 25406462; PMCID: PMC4314224.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Panigrahy D, Adini I, Mamluk R, Levonyak N, Bruns CJ, D'Amore PA, Klagsbrun M, Bielenberg DR. Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology. 2014 Aug; 46(5):416-23. PMID: 24977735.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  14. Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest. 2014 Jan; 124(1):425-36. PMID: 24355922; PMCID: PMC3871226.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  15. Rogers MS, Adini I, McBride AF, Birsner AE, D'Amato RJ. The albino mutation of tyrosinase alters ocular angiogenic responsiveness. Angiogenesis. 2013 Jul; 16(3):639-46. PMID: 23423728.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Khedkar S, Bagchi M, Sherris D, Prendergast GC, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA, Benjamin LE. RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nat Commun. 2013; 4:2824. PMID: 24280686.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, Luyindula D, D'Amato RJ. The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis. 2013 Apr; 16(2):405-16. PMID: 23150059.
    Citations: 19     Fields:    Translation:HumansCells
  18. Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR. A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Oncogene. 2012 May 03; 31(18):2362-72. PMID: 21963851.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Greenberger S, Adini I, Boscolo E, Mulliken JB, Bischoff J. Targeting NF-?B in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis. 2010 Dec; 13(4):327-35. PMID: 20872175.
    Citations: 22     Fields:    Translation:HumansCells
  20. Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med. 2010 Mar 18; 362(11):1005-13. PMID: 20237346; PMCID: PMC2845924.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  21. Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1344-51. PMID: 19304944.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  22. Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'Amato R, Folkman J. Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J. 2008 Oct; 22(10):3728-35. PMID: 18606869.
    Citations: 31     Fields:    Translation:AnimalsCells
  23. Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, D'Amato RJ, Folkman J. An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol. 2008 Jul; 26(7):799-807. PMID: 18587385.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  24. Pakneshan P, Birsner AE, Adini I, Becker CM, D'Amato RJ. Differential suppression of vascular permeability and corneal angiogenesis by nonsteroidal anti-inflammatory drugs. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3909-13. PMID: 18487370.
    Citations: 20     Fields:    Translation:Animals
  25. Fainaru O, Adini A, Benny O, Adini I, Short S, Bazinet L, Nakai K, Pravda E, Hornstein MD, D'Amato RJ, Folkman J. Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. FASEB J. 2008 Feb; 22(2):522-9. PMID: 17873101.
    Citations: 35     Fields:    Translation:AnimalsCells
  26. Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE. RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 2003 Nov 01; 17(21):2721-32. PMID: 14597666; PMCID: PMC280621.
    Citations: 75     Fields:    Translation:AnimalsCells
  27. Adini I, Ephros M, Chen J, Jaffe CL. Asymptomatic visceral leishmaniasis, northern Israel. Emerg Infect Dis. 2003 Mar; 9(3):397-8. PMID: 12643842; PMCID: PMC2958537.
    Citations: 4     Fields:    Translation:Humans
  28. Baneth G, Dank G, Keren-Kornblatt E, Sekeles E, Adini I, Eisenberger CL, Schnur LF, King R, Jaffe CL. Emergence of visceral leishmaniasis in central Israel. Am J Trop Med Hyg. 1998 Nov; 59(5):722-5. PMID: 9840588.
    Citations: 25     Fields:    Translation:HumansAnimals
  29. Adini I, Jacobson RL, Kasap M, Schlein Y, Jaffe CL. Species-specific detection of Leishmania in sandflies using an enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg. 1998 Jan-Feb; 92(1):35-7. PMID: 9692146.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.