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Peter Karl Sorger, Ph.D.

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Biography
Harvard College, Cambridge MAA.B1984Biochemistry
Cambridge University, Cambridge UKPhD1987Biochemistry
UCSF-Varmus Lab, San FranciscoPosdoc1993Cancer Biology
1984
A.B. Summa Cum Laude, Hoopes Prizes for Undergraduate Thesis
1988
Ph.D. in Biochemistry
2003
Director, Cell Decision Processes Center

Overview
Research in the Sorger Lab focuses on signal transduction networks controlling cell proliferation and death, dysregulation of these networks in cancer and inflammation and mechanisms of action of therapeutic drugs targeting signaling proteins. His group uses mathematical and experimental approaches to construct and test computational models of oncogenic and signaling networks in cell lines, patient-derived cells and murine disease models. The Sorger Lab also develops open-source software for analyzing biological networks and drug mechanism of action and it participates in multiple collaborative programs working to improve data access and reproducibility. Recent research extends a systems pharmacology approach to high-dimensional analysis of biopsy samples and the interpretation of clinical trials.

As founding head of the Harvard Program in Therapeutic Science (HiTS) and its Laboratory Systems Pharmacology (LSP) Peter leads a multi-institutional effort to advance the basic and translational science used to develop new medicines, create novel drug combinations and identify responsive patients. The LSP applies systems approaches to understanding and mitigating adverse drug effects and to designing new clinical trials. The recently established Harvard-MIT Center of Regulatory Sciences focuses on improving how drugs are evaluated, brought to market and used in patients. HiTS includes faculty from seven institutions.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U2CCA233262 (SORGER, PETER KARL) Sep 30, 2018 - Jun 30, 2023
    NIH/NCI
    Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
    Role: Principal Investigator
  2. U54CA225088 (SORGER, PETER KARL) Mar 8, 2018 - Feb 28, 2023
    NIH/NCI
    Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
    Role: Principal Investigator
  3. R56AG058063 (ALBERS, MARK W) Sep 30, 2017 - Aug 31, 2018
    NIH/NIA
    Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimer's Disease
    Role: Co-Principal Investigator
  4. U54HL127365 (SORGER, PETER KARL) Sep 10, 2014 - Jun 30, 2020
    NIH/NHLBI
    Pharmaco Response Signatures and Disease Mechanism
    Role: Principal Investigator
  5. P50GM107618 (SORGER, PETER KARL) Sep 1, 2014 - May 31, 2019
    NIH/NIGMS
    The HMS Laboratory of Systems Pharmacology
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hafner M, Mills CE, Subramanian K, Chen C, Chung M, Boswell SA, Everley RA, Liu C, Walmsley CS, Juric D, Sorger PK. Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity. Cell Chem Biol. 2019 Jun 06. PMID: 31178407.
    Citations:    
  2. Todorov PV, Gyori BM, Bachman JA, Sorger PK. INDRA-IPM: interactive pathway modeling using natural language with automated assembly. Bioinformatics. 2019 May 09. PMID: 31070726.
    Citations:    
  3. Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK. Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Syst. 2019 May 22; 8(5):412-426.e7. PMID: 31078528.
    Citations:    
  4. Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol. 2019 Jun 20; 26(6):818-829.e9. PMID: 30982749.
    Citations:    
  5. Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK. Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. Cell Chem Biol. 2019 May 16; 26(5):765-777.e3. PMID: 30956147.
    Citations:    
  6. Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Jun 20; 26(6):804-817.e12. PMID: 30930164.
    Citations:    
  7. Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20; 26(6):792-803.e10. PMID: 30905681.
    Citations:    
  8. Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS. A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers. J Biol Chem. 2019 May 24; 294(21):8664-8673. PMID: 30858179.
    Citations:    
  9. Rapisuwon S, Izar B, Batenchuk C, Avila A, Mei S, Sorger P, Parks JM, Cooper SJ, Wagner D, Zeck JC, Charabaty AJ, Atkins MB. Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors. J Immunother Cancer. 2019 Mar 04; 7(1):61. PMID: 30832716.
    Citations:    
  10. Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK. A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data. 2019 02 19; 6:190016. PMID: 30778261.
    Citations:    
  11. Dunn IF, Du Z, Touat M, Sisti MB, Wen PY, Umeton R, Dubuc AM, Ducar M, Canoll PD, Severson E, Elvin JA, Ramkissoon SH, Lin JR, Cabrera L, Acevedo B, Sorger PK, Ligon KL, Santagata S, Reardon DA. Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis Oncol. 2018; 2018. PMID: 30801050.
    Citations:    
  12. Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 Nov 01; 175(4):984-997.e24. PMID: 30388455.
    Citations:    Fields:    
  13. Lin JR, Izar B, Wang S, Yapp C, Mei S, Shah PM, Santagata S, Sorger PK. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. Elife. 2018 07 11; 7. PMID: 29993362.
    Citations:    Fields:    
  14. Coy S, Rashid R, Lin JR, Du Z, Donson AM, Hankinson TC, Foreman NK, Manley PE, Kieran MW, Reardon DA, Sorger PK, Santagata S. Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma. Neuro Oncol. 2018 Jul 05; 20(8):1101-1112. PMID: 29509940.
    Citations:    
  15. Bachman JA, Gyori BM, Sorger PK. FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining. BMC Bioinformatics. 2018 06 28; 19(1):248. PMID: 29954318.
    Citations:    Fields:    
  16. Sampattavanich S, Steiert B, Kramer BA, Gyori BM, Albeck JG, Sorger PK. Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases. Cell Syst. 2018 Jun 27; 6(6):664-678.e9. PMID: 29886111.
    Citations:    Fields:    
  17. Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T. A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling. ACS Chem Biol. 2018 04 20; 13(4):1066-1081. PMID: 29553248.
    Citations:    Fields:    
  18. Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal. 2018 Mar 06; 11(520). PMID: 29511118.
    Citations: 1     Fields:    
  19. Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018 02 20; 22(8):1945-1955. PMID: 29466723.
    Citations:    Fields:    
  20. Palmer AC, Sorger PK. Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy. Cell. 2017 Dec 14; 171(7):1678-1691.e13. PMID: 29245013.
    Citations: 5     Fields:    Translation:HumansAnimals
  21. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 Jan 24; 6(1):13-24. PMID: 29199020.
    Citations: 14     Fields:    
  22. Gyori BM, Bachman JA, Subramanian K, Muhlich JL, Galescu L, Sorger PK. From word models to executable models of signaling networks using automated assembly. Mol Syst Biol. 2017 11 24; 13(11):954. PMID: 29175850.
    Citations: 5     Fields:    Translation:HumansCells
  23. Hafner M, Heiser LM, Williams EH, Niepel M, Wang NJ, Korkola JE, Gray JW, Sorger PK. Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics. Sci Data. 2017 11 07; 4:170166. PMID: 29112189.
    Citations:    Fields:    Translation:HumansCells
  24. Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma'ayan A, Sorger PK. Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nat Commun. 2017 10 30; 8(1):1186. PMID: 29084964.
    Citations: 3     Fields:    Translation:HumansCells
  25. Clark NA, Hafner M, Kouril M, Williams EH, Muhlich JL, Pilarczyk M, Niepel M, Sorger PK, Medvedovic M. GRcalculator: an online tool for calculating and mining dose-response data. BMC Cancer. 2017 Oct 24; 17(1):698. PMID: 29065900.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Werbin JL, Avendaño MS, Becker V, Jungmann R, Yin P, Danuser G, Sorger PK. Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Sci Rep. 2017 09 22; 7(1):12150. PMID: 28939861.
    Citations:    Fields:    
  27. Niepel M, Hafner M, Chung M, Sorger PK. Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells. Curr Protoc Chem Biol. 2017 Jun 19; 9(2):55-74. PMID: 28628199.
    Citations: 3     Fields:    Translation:HumansCells
  28. Hafner M, Niepel M, Subramanian K, Sorger PK. Designing Drug-Response Experiments and Quantifying their Results. Curr Protoc Chem Biol. 2017 Jun 19; 9(2):96-116. PMID: 28628201.
    Citations: 3     Fields:    
  29. Hafner M, Niepel M, Sorger PK. Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics. Nat Biotechnol. 2017 06 07; 35(6):500-502. PMID: 28591115.
    Citations: 6     Fields:    Translation:HumansCells
  30. Suderman R, Bachman JA, Smith A, Sorger PK, Deeds EJ. Fundamental trade-offs between information flow in single cells and cellular populations. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):5755-5760. PMID: 28500273.
    Citations: 6     Fields:    Translation:HumansCells
  31. Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK. Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma. Elife. 2017 03 20; 6. PMID: 28318489.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Fallahi-Sichani M, Becker V, Izar B, Baker GJ, Lin JR, Boswell SA, Shah P, Rotem A, Garraway LA, Sorger PK. Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Mol Syst Biol. 2017 01 09; 13(1):905. PMID: 28069687.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  33. Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS. Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem. 2017 02 01; 25(3):838-846. PMID: 28011204.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS. Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Bioorg Med Chem. 2017 02 15; 25(4):1320-1328. PMID: 28038940.
    Citations:    Fields:    Translation:HumansCells
  35. Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK. Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):251-264. PMID: 27925668.
    Citations: 3     Fields:    Translation:HumansCells
  36. Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nat Chem Biol. 2017 Jan; 13(1):38-45. PMID: 27820799.
    Citations: 11     Fields:    Translation:HumansCells
  37. Duan Q, Reid SP, Clark NR, Wang Z, Fernandez NF, Rouillard AD, Readhead B, Tritsch SR, Hodos R, Hafner M, Niepel M, Sorger PK, Dudley JT, Bavari S, Panchal RG, Ma'ayan A. L1000CDS2: LINCS L1000 characteristic direction signatures search engine. NPJ Syst Biol Appl. 2016; 2. PMID: 28413689.
    Citations: 16     
  38. Shi T, Niepel M, McDermott JE, Gao Y, Nicora CD, Chrisler WB, Markillie LM, Petyuk VA, Smith RD, Rodland KD, Sorger PK, Qian WJ, Wiley HS. Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway. Sci Signal. 2016 07 12; 9(436):rs6. PMID: 27405981.
    Citations: 16     Fields:    Translation:HumansCells
  39. AlQuraishi M, Sorger PK. Reproducibility will only come with data liberation. Sci Transl Med. 2016 05 18; 8(339):339ed7. PMID: 27194726.
    Citations: 1     Fields:    Translation:Humans
  40. Hafner M, Niepel M, Chung M, Sorger PK. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Nat Methods. 2016 06; 13(6):521-7. PMID: 27135972.
    Citations: 30     Fields:    Translation:HumansCells
  41. Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016 Apr 08; 352(6282):189-96. PMID: 27124452.
    Citations: 203     Fields:    Translation:HumansCells
  42. Lin JR, Fallahi-Sichani M, Sorger PK. Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method. Nat Commun. 2015 Sep 24; 6:8390. PMID: 26399630.
    Citations: 30     Fields:    Translation:HumansCells
  43. Roux J, Hafner M, Bandara S, Sims JJ, Hudson H, Chai D, Sorger PK. Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold. Mol Syst Biol. 2015 May 07; 11(5):803. PMID: 25953765.
    Citations: 15     Fields:    Translation:HumansCells
  44. Flusberg DA, Sorger PK. Surviving apoptosis: life-death signaling in single cells. Trends Cell Biol. 2015 Aug; 25(8):446-58. PMID: 25920803.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  45. Fallahi-Sichani M, Moerke NJ, Niepel M, Zhang T, Gray NS, Sorger PK. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015 Mar 26; 11(3):797. PMID: 25814555.
    Citations: 17     Fields:    Translation:HumansCells
  46. Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014 Nov 06; 159(4):844-56. PMID: 25417160.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  47. AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK. A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nat Genet. 2014 Dec; 46(12):1363-1371. PMID: 25362484.
    Citations: 16     Fields:    Translation:HumansCells
  48. Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13427-32. PMID: 25197064.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  49. Hyman BT, Sorger P. Failure analysis of clinical trials to test the amyloid hypothesis. Ann Neurol. 2014 Aug; 76(2):159-61. PMID: 25044380.
    Citations: 4     Fields:    Translation:Humans
  50. Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W449-60. PMID: 24906883.
    Citations: 59     Fields:    Translation:HumansCells
  51. Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK. Analysis of growth factor signaling in genetically diverse breast cancer lines. BMC Biol. 2014 Mar 21; 12:20. PMID: 24655548.
    Citations: 15     Fields:    Translation:HumansCells
  52. Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R. Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal. 2014 Mar 11; 7(316):ra23. PMID: 24619646.
    Citations: 13     Fields:    Translation:HumansCells
  53. Koch Y, Wolf T, Sorger PK, Eils R, Brors B. Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states. PLoS One. 2013; 8(12):e82593. PMID: 24367526.
    Citations:    Fields:    
  54. Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A. BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Mol Cell. 2013 Sep 26; 51(6):751-65. PMID: 24074954.
    Citations: 65     Fields:    Translation:HumansCells
  55. Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, Sorger PK. Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci Signal. 2013 Sep 24; 6(294):ra84. PMID: 24065145.
    Citations: 36     Fields:    Translation:HumansCells
  56. Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat Chem Biol. 2013 Nov; 9(11):708-14. PMID: 24013279.
    Citations: 62     Fields:    Translation:HumansCells
  57. Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G. S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell. 2013 Aug 29; 154(5):1127-1139. PMID: 23993100.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  58. Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, Stuart JM. Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). Bioinformatics. 2013 Nov 01; 29(21):2757-64. PMID: 23986566.
    Citations: 36     Fields:    Translation:HumansCells
  59. Flusberg DA, Sorger PK. Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging. Phys Biol. 2013 Jun; 10(3):035002. PMID: 23735516.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  60. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200. PMID: 23699397.
    Citations: 24     Fields:    Translation:HumansCells
  61. McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, Gygi SP. Mass spectrometry based method to increase throughput for kinome analyses using ATP probes. Anal Chem. 2013 May 07; 85(9):4666-74. PMID: 23607489.
    Citations: 11     Fields:    Translation:HumansCells
  62. Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A. Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2928-33. PMID: 23382243.
    Citations: 10     Fields:    Translation:AnimalsCells
  63. Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Mol Cell Proteomics. 2013 May; 12(5):1204-13. PMID: 23358503.
    Citations: 10     Fields:    Translation:HumansCells
  64. Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504. PMID: 23422672.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  65. Lopez CF, Muhlich JL, Bachman JA, Sorger PK. Programming biological models in Python using PySB. Mol Syst Biol. 2013; 9:646. PMID: 23423320.
    Citations: 30     Fields:    Translation:Cells
  66. Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK. Properties of cell death models calibrated and compared using Bayesian approaches. Mol Syst Biol. 2013; 9:644. PMID: 23385484.
    Citations: 27     Fields:    
  67. Sorger PK, Schoeberl B. An expanding role for cell biologists in drug discovery and pharmacology. Mol Biol Cell. 2012 Nov; 23(21):4162-4. PMID: 23112228.
    Citations: 4     Fields:    Translation:Humans
  68. Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 2013 Jul 18; 32(29):3470-6. PMID: 22945653.
    Citations: 23     Fields:    Translation:HumansCells
  69. Bagci-Onder T, Agarwal A, Flusberg D, Wanningen S, Sorger P, Shah K. Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors. Oncogene. 2013 Jun 06; 32(23):2818-27. PMID: 22824792.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  70. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283.
    Citations: 204     Fields:    Translation:HumansCells
  71. Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol. 2012 May 01; 6:29. PMID: 22548703.
    Citations: 28     Fields:    Translation:Cells
  72. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482. PMID: 22570596.
    Citations: 36     Fields:    Translation:HumansAnimals
  73. Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27; 19(1):140-54. PMID: 22284361.
    Citations: 69     Fields:    Translation:HumansCells
  74. Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Sci Signal. 2012 Jan 10; 5(206):pl1. PMID: 22234610.
    Citations: 8     Fields:    Translation:HumansCells
  75. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 2012 Mar 23; 287(13):9742-52. PMID: 22223645.
    Citations: 41     Fields:    Translation:HumansCells
  76. Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol Syst Biol. 2011 Nov 22; 7:553. PMID: 22108795.
    Citations: 24     Fields:    Translation:HumansCells
  77. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell. 2011 Nov; 22(22):4236-46. PMID: 21965286.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  78. Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol Cell. 2011 Sep 02; 43(5):723-37. PMID: 21884975.
    Citations: 51     Fields:    Translation:HumansCells
  79. Rines DR, Thomann D, Dorn JF, Goodwin P, Sorger PK. Live cell imaging of yeast. Cold Spring Harb Protoc. 2011 Sep 01; 2011(9). PMID: 21880825.
    Citations: 9     Fields:    Translation:Animals
  80. Prill RJ, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Stolovitzky G. Crowdsourcing network inference: the DREAM predictive signaling network challenge. Sci Signal. 2011 Aug 30; 4(189):mr7. PMID: 21900204.
    Citations: 40     Fields:    Translation:Cells
  81. Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Res. 2011 Aug 15; 71(16):5400-11. PMID: 21742771.
    Citations: 45     Fields:    Translation:HumansCells
  82. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16. PMID: 21712408.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  83. Hached K, Xie SZ, Buffin E, Cladière D, Rachez C, Sacras M, Sorger PK, Wassmann K. Mps1 at kinetochores is essential for female mouse meiosis I. Development. 2011 Jun; 138(11):2261-71. PMID: 21558374.
    Citations: 44     Fields:    Translation:AnimalsCells
  84. Millard BL, Niepel M, Menden MP, Muhlich JL, Sorger PK. Adaptive informatics for multifactorial and high-content biological data. Nat Methods. 2011 Jun; 8(6):487-93. PMID: 21516115.
    Citations: 24     Fields:    Translation:HumansCells
  85. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. PMID: 21467141.
    Citations: 5     Fields:    Translation:AnimalsCells
  86. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39. PMID: 21414484.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  87. Luckert K, Götschel F, Sorger PK, Hecht A, Joos TO, Pötz O. Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics. 2011 May; 10(5):M110.007377. PMID: 21378377.
    Citations: 8     Fields:    Translation:HumansCells
  88. Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. PLoS Comput Biol. 2011 Mar; 7(3):e1001099. PMID: 21408212.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  89. Bachman JA, Sorger P. New approaches to modeling complex biochemistry. Nat Methods. 2011 Feb; 8(2):130-1. PMID: 21278724.
    Citations: 10     Fields:    
  90. Chen WW, Niepel M, Sorger PK. Classic and contemporary approaches to modeling biochemical reactions. Genes Dev. 2010 Sep 01; 24(17):1861-75. PMID: 20810646.
    Citations: 61     Fields:    Translation:Cells
  91. Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Mol Biosyst. 2010 Oct; 6(10):1956-72. PMID: 20617251.
    Citations: 3     Fields:    Translation:HumansCells
  92. Yang R, Niepel M, Mitchison TK, Sorger PK. Dissecting variability in responses to cancer chemotherapy through systems pharmacology. Clin Pharmacol Ther. 2010 Jul; 88(1):34-8. PMID: 20520606.
    Citations: 20     Fields:    Translation:HumansAnimals
  93. Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Mol Cell Proteomics. 2010 Sep; 9(9):1849-65. PMID: 20460255.
    Citations: 47     Fields:    Translation:HumansCells
  94. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. PMID: 20416044.
    Citations: 6     Fields:    Translation:Cells
  95. Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA. Logic-based models for the analysis of cell signaling networks. Biochemistry. 2010 Apr 20; 49(15):3216-24. PMID: 20225868.
    Citations: 85     Fields:    Translation:Cells
  96. Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res. 2010 May 01; 70(9):3843-50. PMID: 20406974.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  97. Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Mol Biosyst. 2010 Jul; 6(7):1195-206. PMID: 20361094.
    Citations: 19     Fields:    Translation:HumansCells
  98. Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. PLoS One. 2010 Feb 23; 5(2):e9202. PMID: 20186320.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  99. Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Mol Syst Biol. 2009; 5:331. PMID: 19953085.
    Citations: 107     Fields:    Translation:HumansCells
  100. Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P. Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS One. 2009 Oct 28; 4(10):e7640. PMID: 19893618.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  101. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61. PMID: 19833543.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  102. Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. PLoS Comput Biol. 2009 Aug; 5(8):e1000438. PMID: 19662154.
    Citations: 61     Fields:    Translation:HumansCells
  103. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. PMID: 19363473.
    Citations: 321     Fields:    Translation:HumansCells
  104. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol. 2009 Jun 15; 237(3):317-30. PMID: 19362101.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  105. Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol. 2009 Apr; 5(4):e1000340. PMID: 19343194.
    Citations: 53     Fields:    Translation:HumansCells
  106. Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol Syst Biol. 2009; 5:239. PMID: 19156131.
    Citations: 140     Fields:    Translation:Cells
  107. Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb; 3(1):9-17. PMID: 19383362.
    Citations: 11     Fields:    Translation:Humans
  108. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. PMID: 19053173.
    Citations: 94     Fields:    Translation:HumansCells
  109. Sorger PK. Microfluidics closes in on point-of-care assays. Nat Biotechnol. 2008 Dec; 26(12):1345-6. PMID: 19060870.
    Citations: 20     Fields:    Translation:Humans
  110. Cohen RL, Espelin CW, De Wulf P, Sorger PK, Harrison SC, Simons KT. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. Mol Biol Cell. 2008 Oct; 19(10):4480-91. PMID: 18701705.
    Citations: 30     Fields:    Translation:AnimalsCells
  111. Foijer F, Draviam VM, Sorger PK. Studying chromosome instability in the mouse. Biochim Biophys Acta. 2008 Sep; 1786(1):73-82. PMID: 18706976.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  112. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell. 2008 Apr 11; 30(1):11-25. PMID: 18406323.
    Citations: 140     Fields:    Translation:HumansCells
  113. Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics. 2008 Mar 15; 24(6):840-7. PMID: 18218655.
    Citations: 26     Fields:    
  114. Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS One. 2007 Nov 28; 2(11):e1165. PMID: 18043727.
    Citations: 37     Fields:    Translation:AnimalsCells
  115. Bellizzi JJ, Sorger PK, Harrison SC. Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure. 2007 Nov; 15(11):1422-30. PMID: 17997968.
    Citations: 6     Fields:    Translation:AnimalsCells
  116. Foijer F, Simonis M, van Vliet M, Wessels L, Kerkhoven R, Sorger PK, Te Riele H. Oncogenic pathways impinging on the G2-restriction point. Oncogene. 2008 Feb 14; 27(8):1142-54. PMID: 17700522.
    Citations: 4     Fields:    Translation:AnimalsCells
  117. Jaqaman K, Dorn JF, Marco E, Sorger PK, Danuser G. Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics. Bioinformatics. 2007 Jul 01; 23(13):1666-73. PMID: 17483508.
    Citations: 1     Fields:    Translation:AnimalsCells
  118. Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81. PMID: 17443180.
    Citations: 155     Fields:    Translation:HumansCells
  119. Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol. 2007 May; 9(5):556-64. PMID: 17417629.
    Citations: 45     Fields:    Translation:HumansCells
  120. Aldridge BB, Haller G, Sorger PK, Lauffenburger DA. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage). 2006 Nov; 153(6):425-32. PMID: 17186704.
    Citations: 18     Fields:    
  121. Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12. PMID: 17057751.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  122. Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Physicochemical modelling of cell signalling pathways. Nat Cell Biol. 2006 Nov; 8(11):1195-203. PMID: 17060902.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  123. Jaqaman K, Dorn JF, Jelson GS, Tytell JD, Sorger PK, Danuser G. Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast. Biophys J. 2006 Sep 15; 91(6):2312-25. PMID: 16940476.
    Citations: 4     Fields:    Translation:AnimalsCells
  124. Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol. 2006 Sep; 2(9):458-66. PMID: 16921358.
    Citations: 149     Fields:    
  125. McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J. 2006 Sep 06; 25(17):4033-49. PMID: 16932742.
    Citations: 35     Fields:    Translation:HumansCells
  126. El-Ali J, Sorger PK, Jensen KF. Cells on chips. Nature. 2006 Jul 27; 442(7101):403-11. PMID: 16871208.
    Citations: 318     Fields:    Translation:HumansAnimalsCells
  127. Draviam VM, Shapiro I, Aldridge B, Sorger PK. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 2006 Jun 21; 25(12):2814-27. PMID: 16763565.
    Citations: 74     Fields:    Translation:HumansCells
  128. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9. PMID: 16765893.
    Citations: 48     Fields:    Translation:Cells
  129. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39. PMID: 16564013.
    Citations: 87     Fields:    Translation:HumansCells
  130. Meraldi P, McAinsh AD, Rheinbay E, Sorger PK. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol. 2006; 7(3):R23. PMID: 16563186.
    Citations: 116     Fields:    Translation:AnimalsCells
  131. Tytell JD, Sorger PK. Analysis of kinesin motor function at budding yeast kinetochores. J Cell Biol. 2006 Mar 13; 172(6):861-74. PMID: 16533946.
    Citations: 51     Fields:    Translation:AnimalsCells
  132. Schoeberl B, Pace E, Howard S, Garantcharova V, Kudla A, Sorger PK, Nielsen UB. A data-driven computational model of the ErbB receptor signaling network. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:53-4. PMID: 17946779.
    Citations: 5     Fields:    Translation:Cells
  133. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53. PMID: 16339439.
    Citations: 186     Fields:    Translation:HumansCells
  134. Dorn JF, Jaqaman K, Rines DR, Jelson GS, Sorger PK, Danuser G. Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. Biophys J. 2005 Oct; 89(4):2835-54. PMID: 16192284.
    Citations: 26     Fields:    Translation:AnimalsCells
  135. Burds AA, Lutum AS, Sorger PK. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11296-301. PMID: 16055552.
    Citations: 41     Fields:    Translation:AnimalsCells
  136. Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90. PMID: 16030008.
    Citations: 58     Fields:    Translation:HumansCells
  137. El-Ali J, Gaudet S, Günther A, Sorger PK, Jensen KF. Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem. 2005 Jun 01; 77(11):3629-36. PMID: 15924398.
    Citations: 12     Fields:    Translation:HumansCells
  138. Goldberg IG, Allan C, Burel JM, Creager D, Falconi A, Hochheiser H, Johnston J, Mellen J, Sorger PK, Swedlow JR. The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol. 2005; 6(5):R47. PMID: 15892875.
    Citations: 63     Fields:    
  139. Wei RR, Sorger PK, Harrison SC. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5363-7. PMID: 15809444.
    Citations: 111     Fields:    Translation:AnimalsCells
  140. Hagan RS, Sorger PK. Cell biology: the more MAD, the merrier. Nature. 2005 Mar 31; 434(7033):575-7. PMID: 15800607.
    Citations: 6     Fields:    Translation:Cells
  141. Meraldi P, Sorger PK. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J. 2005 Apr 20; 24(8):1621-33. PMID: 15933723.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  142. Sorger PK. A reductionist's systems biology: opinion. Curr Opin Cell Biol. 2005 Feb; 17(1):9-11. PMID: 15661513.
    Citations: 14     Fields:    Translation:Animals
  143. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol. 2005 Feb; 12(2):138-43. PMID: 15640796.
    Citations: 127     Fields:    Translation:AnimalsCells
  144. Meraldi P, Draviam VM, Sorger PK. Timing and checkpoints in the regulation of mitotic progression. Dev Cell. 2004 Jul; 7(1):45-60. PMID: 15239953.
    Citations: 202     Fields:    Translation:HumansCells
  145. Draviam VM, Xie S, Sorger PK. Chromosome segregation and genomic stability. Curr Opin Genet Dev. 2004 Apr; 14(2):120-5. PMID: 15196457.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  146. Gillett ES, Espelin CW, Sorger PK. Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol. 2004 Feb 16; 164(4):535-46. PMID: 14769859.
    Citations: 91     Fields:    Translation:AnimalsCells
  147. Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61. PMID: 15579231.
    Citations: 42     Fields:    Translation:HumansCells
  148. De Wulf P, McAinsh AD, Sorger PK. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 2003 Dec 01; 17(23):2902-21. PMID: 14633972.
    Citations: 128     Fields:    Translation:AnimalsCells
  149. Espelin CW, Simons KT, Harrison SC, Sorger PK. Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell. 2003 Nov; 14(11):4557-68. PMID: 13679521.
    Citations: 25     Fields:    Translation:AnimalsCells
  150. Thomann D, Dorn J, Sorger PK, Danuser G. Automatic fluorescent tag localization II: Improvement in super-resolution by relative tracking. J Microsc. 2003 Sep; 211(Pt 3):230-48. PMID: 12950472.
    Citations: 15     Fields:    Translation:AnimalsCells
  151. Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9330-5. PMID: 12876202.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  152. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73. PMID: 12832460.
    Citations: 33     Fields:    Translation:HumansCells
  153. Swedlow JR, Goldberg I, Brauner E, Sorger PK. Informatics and quantitative analysis in biological imaging. Science. 2003 Apr 04; 300(5616):100-2. PMID: 12677061.
    Citations: 52     Fields:    
  154. McAinsh AD, Tytell JD, Sorger PK. Structure, function, and regulation of budding yeast kinetochores. Annu Rev Cell Dev Biol. 2003; 19:519-39. PMID: 14570580.
    Citations: 109     Fields:    Translation:AnimalsCells
  155. Fritz J, Cooper EB, Gaudet S, Sorger PK, Manalis SR. Electronic detection of DNA by its intrinsic molecular charge. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14142-6. PMID: 12386345.
    Citations: 43     Fields:    Translation:Cells
  156. Thomann D, Rines DR, Sorger PK, Danuser G. Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J Microsc. 2002 Oct; 208(Pt 1):49-64. PMID: 12366597.
    Citations: 47     Fields:    Translation:AnimalsCells
  157. Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Sci STKE. 2002 Sep 03; 2002(148):pe38. PMID: 12209052.
    Citations: 36     Fields:    Translation:HumansCells
  158. Rines DR, He X, Sorger PK. Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 2002; 351:16-34. PMID: 12073342.
    Citations: 7     Fields:    Translation:Animals
  159. Gillett ES, Sorger PK. Tracing the pathway of spindle assembly checkpoint signaling. Dev Cell. 2001 Aug; 1(2):162-4. PMID: 11702776.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  160. Brown CS, Goodwin PC, Sorger PK. Image metrics in the statistical analysis of DNA microarray data. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):8944-9. PMID: 11481466.
    Citations: 19     Fields:    Translation:Cells
  161. He X, Rines DR, Espelin CW, Sorger PK. Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell. 2001 Jul 27; 106(2):195-206. PMID: 11511347.
    Citations: 122     Fields:    Translation:AnimalsCells
  162. Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol. 2001 Apr; 3(4):429-32. PMID: 11283619.
    Citations: 167     Fields:    Translation:HumansAnimalsCells
  163. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001 Jan 18; 409(6818):355-9. PMID: 11201745.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  164. He X, Asthana S, Sorger PK. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell. 2000 Jun 23; 101(7):763-75. PMID: 10892747.
    Citations: 132     Fields:    Translation:AnimalsCells
  165. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 09; 101(6):635-45. PMID: 10892650.
    Citations: 179     Fields:    Translation:AnimalsCells
  166. Dobles M, Sorger PK. Mitotic checkpoints, genetic instability, and cancer. Cold Spring Harb Symp Quant Biol. 2000; 65:361-8. PMID: 12760051.
    Citations:    Fields:    Translation:HumansAnimalsCells
  167. Norman TC, Smith DL, Sorger PK, Drees BL, O'Rourke SM, Hughes TR, Roberts CJ, Friend SH, Fields S, Murray AW. Genetic selection of peptide inhibitors of biological pathways. Science. 1999 Jul 23; 285(5427):591-5. PMID: 10417390.
    Citations: 32     Fields:    Translation:AnimalsCells
  168. Martinez-Exposito MJ, Kaplan KB, Copeland J, Sorger PK. Retention of the BUB3 checkpoint protein on lagging chromosomes. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8493-8. PMID: 10411903.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  169. Russell ID, Grancell AS, Sorger PK. The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex. J Cell Biol. 1999 May 31; 145(5):933-50. PMID: 10352012.
    Citations: 44     Fields:    Translation:AnimalsCells
  170. Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 1999 Mar 01; 13(5):545-55. PMID: 10072383.
    Citations: 49     Fields:    Translation:AnimalsCells
  171. Severin F, Kaplan K, Sorger P, Hyman T. In vitro assays for studying Saccharomyces cerevisiae kinetochore activity. Methods Cell Biol. 1999; 61:145-53. PMID: 9891313.
    Citations: 2     Fields:    Translation:AnimalsCells
  172. Grancell A, Sorger PK. Chromosome movement: kinetochores motor along. Curr Biol. 1998 May 21; 8(11):R382-5. PMID: 9635184.
    Citations: 2     Fields:    Translation:AnimalsCells
  173. Wiens GR, Sorger PK. Centromeric chromatin and epigenetic effects in kinetochore assembly. Cell. 1998 May 01; 93(3):313-6. PMID: 9590163.
    Citations: 26