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profilePeter Karl Sorger, Ph.D.

TitleOtto Krayer Professor of Systems Pharmacology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology, Warren Alpert Bld. 438
200 Longwood Ave
Boston MA 02115
Phone617/432-6901
Fax617/432-5012
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Other Positions
TitleHead of the Program in Therapeutic Science
InstitutionHarvard Medical School
DepartmentHarvard Program in Therapeutic Science


Collapse Biography 
Collapse awards and honors
1984A.B. Summa Cum Laude, Hoopes Prizes for Undergraduate Thesis
1988Ph.D. in Biochemistry
2003Director, Cell Decision Processes Center

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56AG058063     (ALBERS, MARK W)Sep 30, 2017 - Aug 31, 2018
NIH/NIA
Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimer's Disease
Role: Co-Principal Investigator

U54HL127365     (SORGER, PETER KARL)Sep 10, 2014 - Jun 30, 2020
NIH/NHLBI
Pharmaco Response Signatures and Disease Mechanism
Role: Principal Investigator

P50GM107618     (SORGER, PETER KARL)Sep 1, 2014 - May 31, 2019
NIH/NIGMS
The HMS Laboratory of Systems Pharmacology
Role: Principal Investigator

U54HG006097     (SORGER, PETER KARL)Sep 27, 2010 - Jul 31, 2014
NIH/NHGRI
Pharmaco Response Signatures and Disease Mechanism
Role: Co-Principal Investigator

P01CA139980     (MITCHISON, TIMOTHY J)Jun 1, 2010 - May 31, 2015
NIH/NCI
Mechanistic Pharmacology of Anti-Mitotics and Apoptosis Regulation
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma'ayan A, Sorger PK. Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nat Commun. 2017 Oct 30; 8(1):1186. PMID: 29084964.
    View in: PubMed
  2. Clark NA, Hafner M, Kouril M, Williams EH, Muhlich JL, Pilarczyk M, Niepel M, Sorger PK, Medvedovic M. GRcalculator: an online tool for calculating and mining dose-response data. BMC Cancer. 2017 Oct 24; 17(1):698. PMID: 29065900.
    View in: PubMed
  3. Werbin JL, Avendaño MS, Becker V, Jungmann R, Yin P, Danuser G, Sorger PK. Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Sci Rep. 2017 Sep 22; 7(1):12150. PMID: 28939861.
    View in: PubMed
  4. Niepel M, Hafner M, Chung M, Sorger PK. Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells. Curr Protoc Chem Biol. 2017 Jun 19; 9(2):55-74. PMID: 28628199.
    View in: PubMed
  5. Hafner M, Niepel M, Subramanian K, Sorger PK. Designing Drug-Response Experiments and Quantifying their Results. Curr Protoc Chem Biol. 2017 Jun 19; 9(2):96-116. PMID: 28628201.
    View in: PubMed
  6. Hafner M, Niepel M, Sorger PK. Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics. Nat Biotechnol. 2017 Jun 07; 35(6):500-502. PMID: 28591115.
    View in: PubMed
  7. Suderman R, Bachman JA, Smith A, Sorger PK, Deeds EJ. Fundamental trade-offs between information flow in single cells and cellular populations. Proc Natl Acad Sci U S A. 2017 May 30; 114(22):5755-5760. PMID: 28500273.
    View in: PubMed
  8. Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK. Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma. Elife. 2017 Mar 20; 6. PMID: 28318489.
    View in: PubMed
  9. Fallahi-Sichani M, Becker V, Izar B, Baker GJ, Lin JR, Boswell SA, Shah P, Rotem A, Garraway LA, Sorger PK. Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Mol Syst Biol. 2017 Jan 09; 13(1):905. PMID: 28069687.
    View in: PubMed
  10. Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS. Structure-guided development of covalent TAK1 inhibitors. Bioorg Med Chem. 2017 Feb 01; 25(3):838-846. PMID: 28011204.
    View in: PubMed
  11. Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS. Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Bioorg Med Chem. 2017 Feb 15; 25(4):1320-1328. PMID: 28038940.
    View in: PubMed
  12. Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK. Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):251-264. PMID: 27925668.
    View in: PubMed
  13. Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nat Chem Biol. 2017 Jan; 13(1):38-45. PMID: 27820799.
    View in: PubMed
  14. Duan Q, Reid SP, Clark NR, Wang Z, Fernandez NF, Rouillard AD, Readhead B, Tritsch SR, Hodos R, Hafner M, Niepel M, Sorger PK, Dudley JT, Bavari S, Panchal RG, Ma'ayan A. L1000CDS2: LINCS L1000 characteristic direction signatures search engine. NPJ Syst Biol Appl. 2016; 2. PMID: 28413689.
    View in: PubMed
  15. Shi T, Niepel M, McDermott JE, Gao Y, Nicora CD, Chrisler WB, Markillie LM, Petyuk VA, Smith RD, Rodland KD, Sorger PK, Qian WJ, Wiley HS. Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway. Sci Signal. 2016 Jul 12; 9(436):rs6. PMID: 27405981; PMCID: PMC5036860.
  16. AlQuraishi M, Sorger PK. Reproducibility will only come with data liberation. Sci Transl Med. 2016 May 18; 8(339):339ed7. PMID: 27194726.
    View in: PubMed
  17. Hafner M, Niepel M, Chung M, Sorger PK. Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Nat Methods. 2016 Jun; 13(6):521-7. PMID: 27135972; PMCID: PMC4887336 [Available on 11/02/16].
  18. Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016 Apr 08; 352(6282):189-96. PMID: 27124452; PMCID: PMC4944528.
  19. Lin JR, Fallahi-Sichani M, Sorger PK. Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method. Nat Commun. 2015 Sep 24; 6:8390. PMID: 26399630; PMCID: PMC4587398.
  20. Roux J, Hafner M, Bandara S, Sims JJ, Hudson H, Chai D, Sorger PK. Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold. Mol Syst Biol. 2015 May 07; 11(5):803. PMID: 25953765; PMCID: PMC4461398.
  21. Flusberg DA, Sorger PK. Surviving apoptosis: life-death signaling in single cells. Trends Cell Biol. 2015 Aug; 25(8):446-58. PMID: 25920803; PMCID: PMC4570028.
  22. Fallahi-Sichani M, Moerke NJ, Niepel M, Zhang T, Gray NS, Sorger PK. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015 Mar 26; 11(3):797. PMID: 25814555; PMCID: PMC4380931.
  23. Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014 Nov 06; 159(4):844-56. PMID: 25417160; PMCID: PMC4243058.
  24. AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK. A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nat Genet. 2014 Dec; 46(12):1363-1371. PMID: 25362484; PMCID: PMC4244270.
  25. Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13427-32. PMID: 25197064; PMCID: PMC4169945.
  26. Hyman BT, Sorger P. Failure analysis of clinical trials to test the amyloid hypothesis. Ann Neurol. 2014 Aug; 76(2):159-61. PMID: 25044380.
    View in: PubMed
  27. Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W449-60. PMID: 24906883; PMCID: PMC4086130.
  28. Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK. Analysis of growth factor signaling in genetically diverse breast cancer lines. BMC Biol. 2014 Mar 21; 12:20. PMID: 24655548; PMCID: PMC4234128.
  29. Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R. Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal. 2014 Mar 11; 7(316):ra23. PMID: 24619646; PMCID: PMC4208692.
  30. Koch Y, Wolf T, Sorger PK, Eils R, Brors B. Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states. PLoS One. 2013; 8(12):e82593. PMID: 24367526; PMCID: PMC3867358.
  31. Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A. BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Mol Cell. 2013 Sep 26; 51(6):751-65. PMID: 24074954; PMCID: PMC4164233.
  32. Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, Sorger PK. Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci Signal. 2013 Sep 24; 6(294):ra84. PMID: 24065145; PMCID: PMC3845839.
  33. Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat Chem Biol. 2013 Nov; 9(11):708-14. PMID: 24013279; PMCID: PMC3947796.
  34. Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G. S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell. 2013 Aug 29; 154(5):1127-39. PMID: 23993100; PMCID: PMC3802543.
  35. Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, Stuart JM. Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). Bioinformatics. 2013 Nov 01; 29(21):2757-64. PMID: 23986566; PMCID: PMC3799471.
  36. Flusberg DA, Sorger PK. Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging. Phys Biol. 2013 Jun; 10(3):035002. PMID: 23735516; PMCID: PMC3775495.
  37. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200. PMID: 23699397; PMCID: PMC3708725.
  38. McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, Gygi SP. Mass spectrometry based method to increase throughput for kinome analyses using ATP probes. Anal Chem. 2013 May 07; 85(9):4666-74. PMID: 23607489; PMCID: PMC3771683.
  39. Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A. Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2928-33. PMID: 23382243; PMCID: PMC3581953.
  40. Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Mol Cell Proteomics. 2013 May; 12(5):1204-13. PMID: 23358503; PMCID: PMC3650332.
  41. Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504. PMID: 23422672; PMCID: PMC3579506.
  42. Lopez CF, Muhlich JL, Bachman JA, Sorger PK. Programming biological models in Python using PySB. Mol Syst Biol. 2013; 9:646. PMID: 23423320; PMCID: PMC3588907.
  43. Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK. Properties of cell death models calibrated and compared using Bayesian approaches. Mol Syst Biol. 2013; 9:644. PMID: 23385484; PMCID: PMC3588908.
  44. Sorger PK, Schoeberl B. An expanding role for cell biologists in drug discovery and pharmacology. Mol Biol Cell. 2012 Nov; 23(21):4162-4. PMID: 23112228; PMCID: PMC3484093.
  45. Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 2013 Jul 18; 32(29):3470-6. PMID: 22945653; PMCID: PMC3670968.
  46. Bagci-Onder T, Agarwal A, Flusberg D, Wanningen S, Sorger P, Shah K. Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors. Oncogene. 2013 Jun 06; 32(23):2818-27. PMID: 22824792; PMCID: PMC3676868.
  47. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283; PMCID: PMC3501264.
  48. Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol. 2012 May 01; 6:29. PMID: 22548703; PMCID: PMC3436686.
  49. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482. PMID: 22570596; PMCID: PMC3343095.
  50. Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27; 19(1):140-54. PMID: 22284361; PMCID: PMC3270411.
  51. Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Sci Signal. 2012 Jan 10; 5(206):pl1. PMID: 22234610; PMCID: PMC3465074.
  52. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 2012 Mar 23; 287(13):9742-52. PMID: 22223645; PMCID: PMC3322972.
  53. Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol Syst Biol. 2011 Nov 22; 7:553. PMID: 22108795; PMCID: PMC3261706.
  54. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell. 2011 Nov; 22(22):4236-46. PMID: 21965286; PMCID: PMC3216650.
  55. Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol Cell. 2011 Sep 02; 43(5):723-37. PMID: 21884975; PMCID: PMC3222462.
  56. Rines DR, Thomann D, Dorn JF, Goodwin P, Sorger PK. Live cell imaging of yeast. Cold Spring Harb Protoc. 2011 Sep 01; 2011(9). PMID: 21880825.
    View in: PubMed
  57. Prill RJ, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Stolovitzky G. Crowdsourcing network inference: the DREAM predictive signaling network challenge. Sci Signal. 2011 Aug 30; 4(189):mr7. PMID: 21900204; PMCID: PMC3465072.
  58. Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Res. 2011 Aug 15; 71(16):5400-11. PMID: 21742771; PMCID: PMC3207250.
  59. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16. PMID: 21712408; PMCID: PMC3129392.
  60. Hached K, Xie SZ, Buffin E, Cladière D, Rachez C, Sacras M, Sorger PK, Wassmann K. Mps1 at kinetochores is essential for female mouse meiosis I. Development. 2011 Jun; 138(11):2261-71. PMID: 21558374.
    View in: PubMed
  61. Millard BL, Niepel M, Menden MP, Muhlich JL, Sorger PK. Adaptive informatics for multifactorial and high-content biological data. Nat Methods. 2011 Jun; 8(6):487-93. PMID: 21516115; PMCID: PMC3105758.
  62. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. PMID: 21467141; PMCID: PMC3207249.
  63. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39. PMID: 21414484; PMCID: PMC3087303.
  64. Luckert K, Götschel F, Sorger PK, Hecht A, Joos TO, Pötz O. Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics. 2011 May; 10(5):M110.007377. PMID: 21378377; PMCID: PMC3098597.
  65. Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. PLoS Comput Biol. 2011 Mar; 7(3):e1001099. PMID: 21408212; PMCID: PMC3048376.
  66. Bachman JA, Sorger P. New approaches to modeling complex biochemistry. Nat Methods. 2011 Feb; 8(2):130-1. PMID: 21278724; PMCID: PMC3100653.
  67. Chen WW, Niepel M, Sorger PK. Classic and contemporary approaches to modeling biochemical reactions. Genes Dev. 2010 Sep 01; 24(17):1861-75. PMID: 20810646; PMCID: PMC2932968.
  68. Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Mol Biosyst. 2010 Oct; 6(10):1956-72. PMID: 20617251.
    View in: PubMed
  69. Yang R, Niepel M, Mitchison TK, Sorger PK. Dissecting variability in responses to cancer chemotherapy through systems pharmacology. Clin Pharmacol Ther. 2010 Jul; 88(1):34-8. PMID: 20520606; PMCID: PMC2941986.
  70. Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Mol Cell Proteomics. 2010 Sep; 9(9):1849-65. PMID: 20460255; PMCID: PMC2938121.
  71. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. PMID: 20416044.
    View in: PubMed
  72. Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA. Logic-based models for the analysis of cell signaling networks. Biochemistry. 2010 Apr 20; 49(15):3216-24. PMID: 20225868; PMCID: PMC2853906.
  73. Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res. 2010 May 01; 70(9):3843-50. PMID: 20406974; PMCID: PMC2862125.
  74. Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Mol Biosyst. 2010 Jul; 6(7):1195-206. PMID: 20361094; PMCID: PMC2943488.
  75. Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. PLoS One. 2010 Feb 23; 5(2):e9202. PMID: 20186320; PMCID: PMC2826397.
  76. Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Mol Syst Biol. 2009; 5:331. PMID: 19953085; PMCID: PMC2824489.
  77. Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P. Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS One. 2009 Oct 28; 4(10):e7640. PMID: 19893618; PMCID: PMC2764089.
  78. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61. PMID: 19833543; PMCID: PMC2975492.
  79. Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. PLoS Comput Biol. 2009 Aug; 5(8):e1000438. PMID: 19662154; PMCID: PMC2710522.
  80. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. PMID: 19363473; PMCID: PMC2858974.
  81. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol. 2009 Jun 15; 237(3):317-30. PMID: 19362101; PMCID: PMC3108859.
  82. Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol. 2009 Apr; 5(4):e1000340. PMID: 19343194; PMCID: PMC2663056.
  83. Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol Syst Biol. 2009; 5:239. PMID: 19156131; PMCID: PMC2644173.
  84. Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb; 3(1):9-17. PMID: 19383362; PMCID: PMC2930781.
  85. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. PMID: 19053173.
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  86. Sorger PK. Microfluidics closes in on point-of-care assays. Nat Biotechnol. 2008 Dec; 26(12):1345-6. PMID: 19060870.
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  87. Cohen RL, Espelin CW, De Wulf P, Sorger PK, Harrison SC, Simons KT. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. Mol Biol Cell. 2008 Oct; 19(10):4480-91. PMID: 18701705; PMCID: PMC2555937.
  88. Foijer F, Draviam VM, Sorger PK. Studying chromosome instability in the mouse. Biochim Biophys Acta. 2008 Sep; 1786(1):73-82. PMID: 18706976; PMCID: PMC2923435.
  89. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell. 2008 Apr 11; 30(1):11-25. PMID: 18406323; PMCID: PMC2858979.
  90. Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics. 2008 Mar 15; 24(6):840-7. PMID: 18218655; PMCID: PMC2617752.
  91. Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS One. 2007 Nov 28; 2(11):e1165. PMID: 18043727; PMCID: PMC2082075.
  92. Bellizzi JJ, Sorger PK, Harrison SC. Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure. 2007 Nov; 15(11):1422-30. PMID: 17997968; PMCID: PMC2288795.
  93. Foijer F, Simonis M, van Vliet M, Wessels L, Kerkhoven R, Sorger PK, Te Riele H. Oncogenic pathways impinging on the G2-restriction point. Oncogene. 2008 Feb 14; 27(8):1142-54. PMID: 17700522.
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  94. Jaqaman K, Dorn JF, Marco E, Sorger PK, Danuser G. Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics. Bioinformatics. 2007 Jul 01; 23(13):1666-73. PMID: 17483508.
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  95. Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81. PMID: 17443180.
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  96. Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol. 2007 May; 9(5):556-64. PMID: 17417629.
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  97. Aldridge BB, Haller G, Sorger PK, Lauffenburger DA. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage). 2006 Nov; 153(6):425-32. PMID: 17186704.
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  98. Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12. PMID: 17057751.
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  99. Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Physicochemical modelling of cell signalling pathways. Nat Cell Biol. 2006 Nov; 8(11):1195-203. PMID: 17060902.
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  100. Jaqaman K, Dorn JF, Jelson GS, Tytell JD, Sorger PK, Danuser G. Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast. Biophys J. 2006 Sep 15; 91(6):2312-25. PMID: 16940476; PMCID: PMC1557555.
  101. Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol. 2006 Sep; 2(9):458-66. PMID: 16921358.
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  102. McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J. 2006 Sep 06; 25(17):4033-49. PMID: 16932742; PMCID: PMC1560365.
  103. El-Ali J, Sorger PK, Jensen KF. Cells on chips. Nature. 2006 Jul 27; 442(7101):403-11. PMID: 16871208.
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  104. Draviam VM, Shapiro I, Aldridge B, Sorger PK. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 2006 Jun 21; 25(12):2814-27. PMID: 16763565; PMCID: PMC1500857.
  105. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9. PMID: 16765893.
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  106. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39. PMID: 16564013.
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  107. Meraldi P, McAinsh AD, Rheinbay E, Sorger PK. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol. 2006; 7(3):R23. PMID: 16563186; PMCID: PMC1557759.
  108. Tytell JD, Sorger PK. Analysis of kinesin motor function at budding yeast kinetochores. J Cell Biol. 2006 Mar 13; 172(6):861-74. PMID: 16533946; PMCID: PMC2063730.
  109. Schoeberl B, Pace E, Howard S, Garantcharova V, Kudla A, Sorger PK, Nielsen UB. A data-driven computational model of the ErbB receptor signaling network. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:53-4. PMID: 17946779.
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  110. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53. PMID: 16339439.
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  111. Dorn JF, Jaqaman K, Rines DR, Jelson GS, Sorger PK, Danuser G. Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. Biophys J. 2005 Oct; 89(4):2835-54. PMID: 16192284; PMCID: PMC1366782.
  112. Burds AA, Lutum AS, Sorger PK. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11296-301. PMID: 16055552; PMCID: PMC1182134.
  113. Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90. PMID: 16030008.
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  114. El-Ali J, Gaudet S, Günther A, Sorger PK, Jensen KF. Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem. 2005 Jun 01; 77(11):3629-36. PMID: 15924398.
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  115. Goldberg IG, Allan C, Burel JM, Creager D, Falconi A, Hochheiser H, Johnston J, Mellen J, Sorger PK, Swedlow JR. The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol. 2005; 6(5):R47. PMID: 15892875; PMCID: PMC1175959.
  116. Wei RR, Sorger PK, Harrison SC. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5363-7. PMID: 15809444; PMCID: PMC555962.
  117. Hagan RS, Sorger PK. Cell biology: the more MAD, the merrier. Nature. 2005 Mar 31; 434(7033):575-7. PMID: 15800607.
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  118. Meraldi P, Sorger PK. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J. 2005 Apr 20; 24(8):1621-33. PMID: 15933723; PMCID: PMC1142573.
  119. Sorger PK. A reductionist's systems biology: opinion. Curr Opin Cell Biol. 2005 Feb; 17(1):9-11. PMID: 15661513.
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  120. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol. 2005 Feb; 12(2):138-43. PMID: 15640796.
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  121. Meraldi P, Draviam VM, Sorger PK. Timing and checkpoints in the regulation of mitotic progression. Dev Cell. 2004 Jul; 7(1):45-60. PMID: 15239953.
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  122. Draviam VM, Xie S, Sorger PK. Chromosome segregation and genomic stability. Curr Opin Genet Dev. 2004 Apr; 14(2):120-5. PMID: 15196457.
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  123. Gillett ES, Espelin CW, Sorger PK. Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol. 2004 Feb 16; 164(4):535-46. PMID: 14769859; PMCID: PMC2171994.
  124. Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61. PMID: 15579231.
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  125. De Wulf P, McAinsh AD, Sorger PK. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 2003 Dec 01; 17(23):2902-21. PMID: 14633972; PMCID: PMC289150.
  126. Espelin CW, Simons KT, Harrison SC, Sorger PK. Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell. 2003 Nov; 14(11):4557-68. PMID: 13679521; PMCID: PMC266772.
  127. Thomann D, Dorn J, Sorger PK, Danuser G. Automatic fluorescent tag localization II: Improvement in super-resolution by relative tracking. J Microsc. 2003 Sep; 211(Pt 3):230-48. PMID: 12950472.
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  128. Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9330-5. PMID: 12876202; PMCID: PMC170918.
  129. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73. PMID: 12832460.
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  130. Swedlow JR, Goldberg I, Brauner E, Sorger PK. Informatics and quantitative analysis in biological imaging. Science. 2003 Apr 04; 300(5616):100-2. PMID: 12677061; PMCID: PMC3522889.
  131. McAinsh AD, Tytell JD, Sorger PK. Structure, function, and regulation of budding yeast kinetochores. Annu Rev Cell Dev Biol. 2003; 19:519-39. PMID: 14570580.
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  132. Fritz J, Cooper EB, Gaudet S, Sorger PK, Manalis SR. Electronic detection of DNA by its intrinsic molecular charge. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14142-6. PMID: 12386345; PMCID: PMC137851.
  133. Thomann D, Rines DR, Sorger PK, Danuser G. Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J Microsc. 2002 Oct; 208(Pt 1):49-64. PMID: 12366597.
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  134. Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Sci STKE. 2002 Sep 03; 2002(148):pe38. PMID: 12209052.
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  135. Rines DR, He X, Sorger PK. Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 2002; 351:16-34. PMID: 12073342.
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  136. Gillett ES, Sorger PK. Tracing the pathway of spindle assembly checkpoint signaling. Dev Cell. 2001 Aug; 1(2):162-4. PMID: 11702776.
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  137. Brown CS, Goodwin PC, Sorger PK. Image metrics in the statistical analysis of DNA microarray data. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):8944-9. PMID: 11481466; PMCID: PMC55353.
  138. He X, Rines DR, Espelin CW, Sorger PK. Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell. 2001 Jul 27; 106(2):195-206. PMID: 11511347.
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  139. Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol. 2001 Apr; 3(4):429-32. PMID: 11283619.
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  140. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001 Jan 18; 409(6818):355-9. PMID: 11201745.
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  141. He X, Asthana S, Sorger PK. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell. 2000 Jun 23; 101(7):763-75. PMID: 10892747.
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  142. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 09; 101(6):635-45. PMID: 10892650.
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  143. Dobles M, Sorger PK. Mitotic checkpoints, genetic instability, and cancer. Cold Spring Harb Symp Quant Biol. 2000; 65:361-8. PMID: 12760051.
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  144. Norman TC, Smith DL, Sorger PK, Drees BL, O'Rourke SM, Hughes TR, Roberts CJ, Friend SH, Fields S, Murray AW. Genetic selection of peptide inhibitors of biological pathways. Science. 1999 Jul 23; 285(5427):591-5. PMID: 10417390.
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  145. Martinez-Exposito MJ, Kaplan KB, Copeland J, Sorger PK. Retention of the BUB3 checkpoint protein on lagging chromosomes. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8493-8. PMID: 10411903; PMCID: PMC17544.
  146. Russell ID, Grancell AS, Sorger PK. The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex. J Cell Biol. 1999 May 31; 145(5):933-50. PMID: 10352012; PMCID: PMC2133132.
  147. Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 1999 Mar 01; 13(5):545-55. PMID: 10072383; PMCID: PMC316511.
  148. Severin F, Kaplan K, Sorger P, Hyman T. In vitro assays for studying Saccharomyces cerevisiae kinetochore activity. Methods Cell Biol. 1999; 61:145-53. PMID: 9891313.
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  149. Grancell A, Sorger PK. Chromosome movement: kinetochores motor along. Curr Biol. 1998 May 21; 8(11):R382-5. PMID: 9635184.
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  150. Wiens GR, Sorger PK. Centromeric chromatin and epigenetic effects in kinetochore assembly. Cell. 1998 May 01; 93(3):313-6. PMID: 9590163.
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  151. Espelin CW, Kaplan KB, Sorger PK. Probing the architecture of a simple kinetochore using DNA-protein crosslinking. J Cell Biol. 1997 Dec 15; 139(6):1383-96. PMID: 9396745; PMCID: PMC2132615.
  152. Sorger PK, Dobles M, Tournebize R, Hyman AA. Coupling cell division and cell death to microtubule dynamics. Curr Opin Cell Biol. 1997 Dec; 9(6):807-14. PMID: 9425345.
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  153. Kaplan KB, Hyman AA, Sorger PK. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell. 1997 Nov 14; 91(4):491-500. PMID: 9390558.
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  154. Severin FF, Sorger PK, Hyman AA. Kinetochores distinguish GTP from GDP forms of the microtubule lattice. Nature. 1997 Aug 28; 388(6645):888-91. PMID: 9278051.
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  155. Sorger PK, Doheny KF, Hieter P, Kopski KM, Huffaker TC, Hyman AA. Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12026-30. PMID: 8618837; PMCID: PMC40289.
  156. Hyman AA, Sorger PK. Structure and function of kinetochores in budding yeast. Annu Rev Cell Dev Biol. 1995; 11:471-95. PMID: 8689566.
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  157. Sorger PK, Severin FF, Hyman AA. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. J Cell Biol. 1994 Nov; 127(4):995-1008. PMID: 7962081; PMCID: PMC2200058.
  158. Doheny KF, Sorger PK, Hyman AA, Tugendreich S, Spencer F, Hieter P. Identification of essential components of the S. cerevisiae kinetochore. Cell. 1993 May 21; 73(4):761-74. PMID: 8500169.
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  159. Sorger PK, Murray AW. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature. 1992 Jan 23; 355(6358):365-8. PMID: 1731250.
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  160. Sorger PK. Heat shock factor and the heat shock response. Cell. 1991 May 03; 65(3):363-6. PMID: 2018972.
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  161. Sorger PK. Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell. 1990 Aug 24; 62(4):793-805. PMID: 2201452.
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  162. Sorger PK, Nelson HC. Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell. 1989 Dec 01; 59(5):807-13. PMID: 2686840.
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  163. Sorger PK, Pelham HR. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell. 1988 Sep 09; 54(6):855-64. PMID: 3044613.
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  164. Sorger PK, Pelham HR. Purification and characterization of a heat-shock element binding protein from yeast. EMBO J. 1987 Oct; 6(10):3035-41. PMID: 3319580; PMCID: PMC553740.
  165. Sorger PK, Lewis MJ, Pelham HR. Heat shock factor is regulated differently in yeast and HeLa cells. Nature. 1987 Sep 3-9; 329(6134):81-4. PMID: 3306402.
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  166. Sorger PK, Pelham HR. Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells. EMBO J. 1987 Apr; 6(4):993-8. PMID: 3595567; PMCID: PMC553494.
  167. Sorger PK, Pelham HR. The glucose-regulated protein grp94 is related to heat shock protein hsp90. J Mol Biol. 1987 Mar 20; 194(2):341-4. PMID: 3612810.
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  168. Sorger PK, Stockley PG, Harrison SC. Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro. J Mol Biol. 1986 Oct 20; 191(4):639-58. PMID: 3806677.
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  169. Sorger PK, Crowther RA, Finch JT, Pearse BM. Clathrin cubes: an extreme variant of the normal cage. J Cell Biol. 1986 Oct; 103(4):1213-9. PMID: 3771632; PMCID: PMC2114327.
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