Harvard Catalyst Profiles

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Keertik Fulzele, Ph.D.


The Most Outstanding Abstract Award
Alice L. Jee Memorial Young Investigator Award
First Prize, Annual Research Fellows Poster Celebration
Young Investigator Award
John Haddad Young Investigator Award

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition. Cell. 2022 Feb 17; 185(4):746. PMID: 35180388; PMCID: PMC8959017.
    Citations:    Fields:    
  2. Panaroni C, Fulzele K, Mori T, Siu KT, Onyewadume C, Maebius A, Raje N. Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. Blood. 2022 02 10; 139(6):876-888. PMID: 34662370; PMCID: PMC8832479.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Schroeder P, Fulzele K, Forsyth S, Ribadeneira MD, Guichard S, Wilker E, Marshall CG, Drake A, Fessler R, Konstantinidis DG, Seu KG, Kalfa TA. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 03; 380(3):210-219. PMID: 35031585.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Mori T, Verma R, Nakamoto-Matsubara R, Siu KT, Panaroni C, Fulzele KS, Mukaihara K, Onyewadume C, Maebius A, Kato H, Wong LP, Sadreyev RI, Scadden DT, Raje NS. Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. Blood Cancer J. 2021 12 04; 11(12):194. PMID: 34864816; PMCID: PMC8643354.
    Citations:    Fields:    Translation:HumansCells
  5. Shrestha A, Chi M, Wagner K, Malik A, Korpik J, Drake A, Fulzele K, Guichard S, Malik P. FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. Blood Adv. 2021 05 11; 5(9):2385-2390. PMID: 33944896.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Uda Y, Spatz JM, Hussein A, Garcia JH, Lai F, Dedic C, Fulzele K, Dougherty S, Eberle M, Adamson C, Misener L, Gerstenfeld L, Divieti Pajevic P. Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight. FASEB J. 2021 05; 35(5):e21578. PMID: 33835498.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Verma D, Kumar R, Pereira RS, Karantanou C, Zanetti C, Minciacchi VR, Fulzele K, Kunz K, Hoelper S, Zia-Chahabi S, Jabagi MJ, Emmerich J, Dray-Spira R, Kuhlee F, Hackmann K, Schroeck E, Wenzel P, Müller S, Filmann N, Fontenay M, Pajevic PD, Krause DS. Vitamin K antagonism impairs the bone marrow microenvironment and hematopoiesis. Blood. 2019 07 18; 134(3):227-238. PMID: 31003999; PMCID: PMC7022447.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Siu KT, Huang C, Panaroni C, Mukaihara K, Fulzele K, Soucy R, Thorburn C, Cidado J, Drew L, Chattopadhyay S, Raje N. BCL2 blockade overcomes MCL1 resistance in multiple myeloma. Leukemia. 2019 08; 33(8):2098-2102. PMID: 30816329.
    Citations: 11     Fields:    Translation:Humans
  9. Fulzele K, Dedic C, Lai F, Bouxsein M, Lotinun S, Baron R, Divieti Pajevic P. Loss of Gsa in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity. Bone. 2018 12; 117:138-148. PMID: 30266511; PMCID: PMC6207374.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein AI, Petty CA, Fulzele K, Mitterberger-Vogt MC, Zwerschke W, Pereira R, Wang K, Pajevic PD. Carbonic anhydrase III protects osteocytes from oxidative stress. FASEB J. 2018 01; 32(1):440-452. PMID: 28928248; PMCID: PMC6266636.
    Citations: 12     Fields:    Translation:AnimalsCells
  11. Fulzele K, Lai F, Dedic C, Saini V, Uda Y, Shi C, Tuck P, Aronson JL, Liu X, Spatz JM, Wein MN, Divieti Pajevic P. Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res. 2017 Feb; 32(2):373-384. PMID: 27653320; PMCID: PMC5525330.
    Citations: 32     Fields:    Translation:AnimalsCells
  12. Panaroni C, Fulzele K, Saini V, Chubb R, Pajevic PD, Wu JY. PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. J Bone Miner Res. 2015 Dec; 30(12):2273-86. PMID: 26191777; PMCID: PMC5056164.
    Citations: 19     Fields:    Translation:AnimalsCells
  13. Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Pajevic PD, Kronenberg HM, Wu JY. Loss of Gsa early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors. J Bone Miner Res. 2014 Nov; 29(11):2414-26. PMID: 24806274.
    Citations: 23     Fields:    Translation:AnimalsCells
  14. Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7. PMID: 24162813.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  15. Saini V, Marengi DA, Barry KJ, Fulzele KS, Heiden E, Liu X, Dedic C, Maeda A, Lotinun S, Baron R, Pajevic PD. Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. J Biol Chem. 2013 Jul 12; 288(28):20122-34. PMID: 23729679; PMCID: PMC3711281.
    Citations: 72     Fields:    Translation:AnimalsCells
  16. Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P. Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Blood. 2013 Feb 07; 121(6):930-9. PMID: 23160461; PMCID: PMC3567340.
    Citations: 74     Fields:    Translation:AnimalsCells
  17. Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK, Chen M, Poulton IJ, Purton LE, Sims NA, Weinstein LS, Kronenberg HM. Gsa enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. J Clin Invest. 2011 Sep; 121(9):3492-504. PMID: 21804192; PMCID: PMC3163961.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  18. Fulzele K, Clemens TL. Novel functions for insulin in bone. Bone. 2012 Feb; 50(2):452-6. PMID: 21723973.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  19. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. 2010 Jul 23; 142(2):309-19. PMID: 20655471; PMCID: PMC2925155.
    Citations: 310     Fields:    Translation:AnimalsCells
  20. DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marín de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol. 2010 Mar; 204(3):241-53. PMID: 20032200.
    Citations: 20     Fields:    Translation:AnimalsCells
  21. DiGirolamo DJ, Mukherjee A, Fulzele K, Gan Y, Cao X, Frank SJ, Clemens TL. Mode of growth hormone action in osteoblasts. J Biol Chem. 2007 Oct 26; 282(43):31666-74. PMID: 17698843.
    Citations: 52     Fields:    Translation:AnimalsCells
  22. Fulzele K, DiGirolamo DJ, Liu Z, Xu J, Messina JL, Clemens TL. Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J Biol Chem. 2007 Aug 31; 282(35):25649-58. PMID: 17553792.
    Citations: 61     Fields:    Translation:AnimalsCells
  23. Elder SH, Fulzele KS, McCulley WR. Cyclic hydrostatic compression stimulates chondroinduction of C3H/10T1/2 cells. Biomech Model Mechanobiol. 2005 Mar; 3(3):141-6. PMID: 15668766.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Zayzafoon M, Fulzele K, McDonald JM. Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expression. J Biol Chem. 2005 Feb 25; 280(8):7049-59. PMID: 15590632.
    Citations: 40     Fields:    Translation:AnimalsCells
  25. Datta D, Kundu PK, Dasgupta S, Fulzele K, Sewlikar S. Effect of addition of proton carriers in culture medium on growth and secretion of hybridoma cell line OKT3. Indian J Physiol Pharmacol. 2001 Jul; 45(3):367-72. PMID: 11881578.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.