Harvard Catalyst Profiles

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Arjun Kumar Manrai, Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01HL138259 (MANRAI, ARJUN KUMAR) May 1, 2018 - Apr 30, 2023
    Precision Cardiovascular Medicine for Multi-Ethnic Populations
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Obstfeld AE, Patel K, Boyd JC, Drees J, Holmes DT, Ioannidis JPA, Manrai AK. Data Mining Approaches to Reference Interval Studies. Clin Chem. 2021 Sep 01; 67(9):1175-1181. PMID: 34402506.
    Citations:    Fields:    
  2. Abramoff MD, Cunningham B, Patel B, Eydelman MB, Leng T, Sakamoto T, Blodi B, Grenon SM, Wolf RM, Manrai AK, Ko JM, Chiang MF, Char D. Foundational Considerations for Artificial Intelligence Utilizing Ophthalmic Images. Ophthalmology. 2021 Aug 31. PMID: 34478784.
    Citations:    Fields:    
  3. Diao JA, Powe NR, Manrai AK. Race-Free Equations for eGFR: Comparing Effects on CKD Classification. J Am Soc Nephrol. 2021 Aug; 32(8):1868-1870. PMID: 34326164.
    Citations:    Fields:    
  4. Manrai AK. Physicians, Probabilities, and Populations-Estimating the Likelihood of Disease for Common Clinical Scenarios. JAMA Intern Med. 2021 Jun 01; 181(6):756-757. PMID: 33818590.
    Citations:    Fields:    
  5. Diao JA, Powe NR, Manrai AK. Removing Race From Kidney Function Estimates-Reply. JAMA. 2021 05 18; 325(19):2018-2019. PMID: 34003228.
    Citations:    Fields:    
  6. Pho N, Manrai AK, Leppert JT, Chertow GM, Ioannidis JPA, Patel CJ. Association of 152 Biomarker Reference Intervals with All-Cause Mortality in Participants of a General United States Survey from 1999 to 2010. Clin Chem. 2021 Mar 01; 67(3):500-507. PMID: 33674838.
    Citations: 1     Fields:    
  7. Morales A, Ing A, Antolik C, Austin-Tse C, Baudhuin LM, Bronicki L, Cirino A, Hawley MH, Fietz M, Garcia J, Ho C, Ingles J, Jarinova O, Johnston T, Kelly MA, Kurtz CL, Lebo M, Macaya D, Mahanta L, Maleszewski J, Manrai AK, Murray M, Richard G, Semsarian C, Thomson KL, Winder T, Ware JS, Hershberger RE, Funke BH, Vatta M. Harmonizing the Collection of Clinical Data on Genetic Testing Requisition Forms to Enhance Variant Interpretation in Hypertrophic Cardiomyopathy (HCM): A Study from the ClinGen Cardiomyopathy Variant Curation Expert Panel. J Mol Diagn. 2021 05; 23(5):589-598. PMID: 33631351.
    Citations:    Fields:    
  8. He Y, Lakhani CM, Rasooly D, Manrai AK, Tzoulaki I, Patel CJ. Comparisons of Polyexposure, Polygenic, and Clinical Risk Scores in Risk Prediction of Type 2 Diabetes. Diabetes Care. 2021 Apr; 44(4):935-943. PMID: 33563654.
    Citations: 1     Fields:    
  9. Diao JA, Wu GJ, Taylor HA, Tucker JK, Powe NR, Kohane IS, Manrai AK. Clinical Implications of Removing Race From Estimates of Kidney Function. JAMA. 2021 Jan 12; 325(2):184-186. PMID: 33263721.
    Citations: 9     Fields:    Translation:Humans
  10. Diao JA, Inker LA, Levey AS, Tighiouart H, Powe NR, Manrai AK. In Search of a Better Equation - Performance and Equity in Estimates of Kidney Function. N Engl J Med. 2021 Feb 04; 384(5):396-399. PMID: 33406354.
    Citations: 5     Fields:    Translation:Humans
  11. Passero K, Setia-Verma S, McAllister K, Manrai A, Patel C, Hall M. What about the environment? Leveraging multi-omic datasets to characterize the environment's role in human health. Pac Symp Biocomput. 2021; 26:309-315. PMID: 33691027.
    Citations:    Fields:    
  12. Passero K, Setia-Verma S, McAllister K, Manrai A, Patel C, Hall M. What about the environment? Leveraging multi-omic datasets to characterize the environment's role in human health. Pac Symp Biocomput. 2021; 26:309-315. PMID: 34409132.
    Citations:    Fields:    Translation:Humans
  13. Krissaane I, De Niz C, Gutiérrez-Sacristán A, Korodi G, Ede N, Kumar R, Lyons J, Manrai A, Patel C, Kohane I, Avillach P. Scalability and cost-effectiveness analysis of whole genome-wide association studies on Google Cloud Platform and Amazon Web Services. J Am Med Inform Assoc. 2020 09 01; 27(9):1425-1430. PMID: 32719837.
    Citations:    Fields:    Translation:Humans
  14. Sagers L, Melas-Kyriazi L, Patel CJ, Manrai AK. Prediction of chronological and biological age from laboratory data. Aging (Albany NY). 2020 05 05; 12(9):7626-7638. PMID: 32391803.
    Citations: 2     Fields:    Translation:Humans
  15. Beam AL, Manrai AK, Ghassemi M. Challenges to the Reproducibility of Machine Learning Models in Health Care. JAMA. 2020 01 28; 323(4):305-306. PMID: 31904799.
    Citations: 24     Fields:    Translation:Humans
  16. Manrai AK, Ioannidis JPA, Patel CJ. Signals Among Signals: Prioritizing Nongenetic Associations in Massive Data Sets. Am J Epidemiol. 2019 05 01; 188(5):846-850. PMID: 30877292.
    Citations: 2     Fields:    Translation:Humans
  17. Lakhani CM, Tierney BT, Manrai AK, Yang J, Visscher PM, Patel CJ. Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat Genet. 2019 04; 51(4):764-765. PMID: 30814726.
    Citations: 1     Fields:    
  18. Mandl KD, Manrai AK. Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning. JAMA. 2019 Feb 26; 321(8):739-740. PMID: 30735228.
    Citations: 8     Fields:    Translation:Humans
  19. Lakhani CM, Tierney BT, Manrai AK, Yang J, Visscher PM, Patel CJ. Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat Genet. 2019 02; 51(2):327-334. PMID: 30643253.
    Citations: 14     Fields:    Translation:Humans
  20. Manrai AK, Patel CJ, Ioannidis JPA. Using Big Data to Determine Reference Values for Laboratory Tests-Reply. JAMA. 2018 10 09; 320(14):1496. PMID: 30304422.
    Citations: 1     Fields:    
  21. Manrai AK, Patel CJ, Ioannidis JPA. In the Era of Precision Medicine and Big Data, Who Is Normal? JAMA. 2018 May 15; 319(19):1981-1982. PMID: 29710130.
    Citations: 20     Fields:    Translation:Humans
  22. Diao JA, Kohane IS, Manrai AK. Biomedical informatics and machine learning for clinical genomics. Hum Mol Genet. 2018 05 01; 27(R1):R29-R34. PMID: 29566172.
    Citations: 4     Fields:    Translation:Humans
  23. Kelly MA, Caleshu C, Morales A, Buchan J, Wolf Z, Harrison SM, Cook S, Dillon MW, Garcia J, Haverfield E, Jongbloed JDH, Macaya D, Manrai A, Orland K, Richard G, Spoonamore K, Thomas M, Thomson K, Vincent LM, Walsh R, Watkins H, Whiffin N, Ingles J, van Tintelen JP, Semsarian C, Ware JS, Hershberger R, Funke B. Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen's Inherited Cardiomyopathy Expert Panel. Genet Med. 2018 03; 20(3):351-359. PMID: 29300372.
    Citations: 64     Fields:    Translation:Humans
  24. Palmer N, Beam A, Agniel D, Eran A, Manrai A, Spettell C, Steinberg G, Mandl K, Fox K, Nelson SF, Kohane I. Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings. JAMA Pediatr. 2017 11 01; 171(11):1107-1112. PMID: 28973142.
    Citations: 12     Fields:    Translation:Humans
  25. Jasny BR, Wigginton N, McNutt M, Bubela T, Buck S, Cook-Deegan R, Gardner T, Hanson B, Hustad C, Kiermer V, Lazer D, Lupia A, Manrai A, McConnell L, Noonan K, Phimister E, Simon B, Strandburg K, Summers Z, Watts D. Fostering reproducibility in industry-academia research. Science. 2017 08 25; 357(6353):759-761. PMID: 28839064.
    Citations: 4     Fields:    
  26. Patel CJ, Manrai AK, Corona E, Kohane IS. Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length. Int J Epidemiol. 2017 02 01; 46(1):44-56. PMID: 27059547.
    Citations: 23     Fields:    Translation:HumansCellsPHPublic Health
  27. Karczewski KJ, Tatonetti NP, Manrai AK, Patel CJ, Titus Brown C, Ioannidis JPA. METHODS TO ENSURE THE REPRODUCIBILITY OF BIOMEDICAL RESEARCH. Pac Symp Biocomput. 2017; 22:117-119. PMID: 27896967.
    Citations: 2     Fields:    
  28. Manrai AK, Cui Y, Bushel PR, Hall M, Karakitsios S, Mattingly CJ, Ritchie M, Schmitt C, Sarigiannis DA, Thomas DC, Wishart D, Balshaw DM, Patel CJ. Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. Annu Rev Public Health. 2017 Mar 20; 38:279-294. PMID: 28068484.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  29. Manrai AK, Funke BH, Rehm HL, Olesen MS, Maron BA, Szolovits P, Margulies DM, Loscalzo J, Kohane IS. Genetic Misdiagnoses and the Potential for Health Disparities. N Engl J Med. 2016 Aug 18; 375(7):655-65. PMID: 27532831.
    Citations: 192     Fields:    Translation:Humans
  30. Manrai AK, Ioannidis JP, Kohane IS. Clinical Genomics: From Pathogenicity Claims to Quantitative Risk Estimates. JAMA. 2016 Mar 22-29; 315(12):1233-4. PMID: 26925924.
    Citations: 14     Fields:    Translation:Humans
  31. Manrai AK, Wang BL, Patel CJ, Kohane IS. REPRODUCIBLE AND SHAREABLE QUANTIFICATIONS OF PATHOGENICITY. Pac Symp Biocomput. 2016; 21:231-42. PMID: 26776189.
    Citations: 2     Fields:    Translation:Humans
  32. Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput. 2016; 21:180-2. PMID: 26776184.
  33. Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput. 2016; 21:180-182. PMID: 28004011.
    Citations: 4     Fields:    Translation:Humans
  34. Patel CJ, Manrai AK. Development of exposome correlation globes to map out environment-wide associations. Pac Symp Biocomput. 2015; 231-42. PMID: 25592584.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  35. Manrai AK, Bhatia G, Strymish J, Kohane IS, Jain SH. Medicine's uncomfortable relationship with math: calculating positive predictive value. JAMA Intern Med. 2014 Jun; 174(6):991-3. PMID: 24756486.
    Citations: 18     Fields:    Translation:Humans
  36. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther. 2014 May; 22(5):999-1007. PMID: 24496384.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  37. Manrai AK, Kohane IS, Szolovits P. Urinary-cell mRNA and acute kidney-transplant rejection. N Engl J Med. 2013 11 07; 369(19):1859. PMID: 24195557.
    Citations:    Fields:    Translation:Humans
  38. Shin H, Liu T, Manrai AK, Liu XS. CEAS: cis-regulatory element annotation system. Bioinformatics. 2009 Oct 01; 25(19):2605-6. PMID: 19689956.
    Citations: 268     Fields:    Translation:Cells
  39. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell. 2009 Jul 23; 138(2):245-56. PMID: 19632176.
    Citations: 432     Fields:    Translation:HumansCells
  40. Manrai AK, Gunawardena J. The geometry of multisite phosphorylation. Biophys J. 2008 Dec 15; 95(12):5533-43. PMID: 18849417.
    Citations: 19     Fields:    Translation:Cells
  41. Song JS, Johnson WE, Zhu X, Zhang X, Li W, Manrai AK, Liu JS, Chen R, Liu XS. Model-based analysis of two-color arrays (MA2C). Genome Biol. 2007; 8(8):R178. PMID: 17727723.
    Citations: 74     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.