Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lee Josephson, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EB017699 (NORMANDIN, MARC DAVID) Sep 22, 2014 - May 31, 2019
    PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability Retention
    Role: Co-Principal Investigator
  2. R01EB011996 (JOSEPHSON, LEE) Jul 15, 2010 - Jul 30, 2014
    Multimodal Vital Fluorochromes for Imaging
    Role: Principal Investigator
  3. R01EB009691 (JOSEPHSON, LEE) Jul 1, 2009 - Jun 30, 2013
    Reagents for the Design of Targeted Multifunctional Nanomaterials
    Role: Principal Investigator
  4. R01EB004472 (JOSEPHSON, LEE) Sep 15, 2005 - Jun 30, 2010
    Imaging of Pharmacotherapy Induced Apoptosis
    Role: Principal Investigator
  5. R01EB000662 (JOSEPHSON, LEE) Sep 15, 2002 - Aug 31, 2007
    High Thoroughput Development of Molecular Imaging Agents
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sun J, Xiao Z, Haider A, Gebhard C, Xu H, Luo HB, Zhang HT, Josephson L, Wang L, Liang SH. Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery. J Med Chem. 2021 06 10; 64(11):7083-7109. PMID: 34042442.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Chen Z, Mori W, Rong J, Schafroth MA, Shao T, Van RS, Ogasawara D, Yamasaki T, Hiraishi A, Hatori A, Chen J, Zhang Y, Hu K, Fujinaga M, Sun J, Yu Q, Collier TL, Shao Y, Cravatt BF, Josephson L, Zhang MR, Liang SH. Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping. Acta Pharm Sin B. 2021 Jun; 11(6):1686-1695. PMID: 34221877.
  3. Knight AC, Varlow C, Zi T, Liang SH, Josephson L, Schmidt K, Patel S, Vasdev N. In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R. ACS Chem Neurosci. 2021 03 17; 12(6):998-1006. PMID: 33667059.
    Citations:    Fields:    Translation:AnimalsCells
  4. Gholami YH, Yuan H, Wilks MQ, Josephson L, El Fakhri G, Normandin MD, Kuncic Z. Positron annihilation localization by nanoscale magnetization. Sci Rep. 2020 11 20; 10(1):20262. PMID: 33219274.
    Citations:    Fields:    Translation:Humans
  5. Zhang L, Hu K, Shao T, Hou L, Zhang S, Ye W, Josephson L, Meyer JH, Zhang MR, Vasdev N, Wang J, Xu H, Wang L, Liang SH. Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharm Sin B. 2021 Feb; 11(2):373-393. PMID: 33643818.
    Citations: 4     
  6. Sun JY, Kumata K, Chen Z, Zhang YD, Chen JH, Hatori A, Fu HL, Rong J, Deng XY, Yamasaki T, Xie L, Hu K, Fujinaga M, Yu QZ, Shao T, Collier TL, Josephson L, Shao YH, Du YF, Wang L, Xu H, Zhang MR, Liang SH. Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators. Acta Pharmacol Sin. 2021 Mar; 42(3):491-498. PMID: 32661351.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Deng X, Zhang Y, Chen Z, Kumata K, Van R, Rong J, Shao T, Hatori A, Mori W, Yu Q, Hu K, Fujinaga M, Wey HY, Shao Y, Josephson L, Murtas G, Pollegioni L, Zhang MR, Liang S. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging. Bioorg Med Chem Lett. 2020 08 15; 30(16):127326. PMID: 32631531.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Chen Z, Chen J, Mast N, Rong J, Deng X, Shao T, Fu H, Yu Q, Sun J, Shao Y, Josephson L, Collier TL, Pikuleva I, Liang SH. Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [11C]CO2 fixation method. Bioorg Med Chem Lett. 2020 05 01; 30(9):127068. PMID: 32178974.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Shao T, Chen Z, Belov V, Wang X, Rwema SH, Kumar V, Fu H, Deng X, Rong J, Yu Q, Lang L, Lin W, Josephson L, Samir AE, Chen X, Chung RT, Liang SH. [18F]-Alfatide PET imaging of integrin avß3 for the non-invasive quantification of liver fibrosis. J Hepatol. 2020 07; 73(1):161-169. PMID: 32145257.
    Citations: 2     Fields:    
  10. Gholami YH, Yuan H, Wilks MQ, Maschmeyer R, Normandin MD, Josephson L, El Fakhri G, Kuncic Z. A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging. Int J Nanomedicine. 2020; 15:1253-1266. PMID: 32161456.
    Citations: 2     Fields:    Translation:Humans
  11. Tam JM, Josephson L, Pilozzi AR, Huang X. A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D. Molecules. 2020 Jan 09; 25(2). PMID: 31936569.
    Citations: 2     Fields:    Translation:HumansCells
  12. Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. Int J Nanomedicine. 2020; 15:31-47. PMID: 32021163.
    Citations: 3     Fields:    
  13. Yu Q, Kumata K, Li H, Zhang Y, Chen Z, Zhang X, Shao T, Hatori A, Yamasaki T, Xie L, Hu K, Wang G, Josephson L, Sun S, Zhang MR, Liang SH. Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging ?-8 dependent transmembrane AMPA receptor regulatory protein by PET. Bioorg Med Chem Lett. 2020 02 15; 30(4):126879. PMID: 31879207.
    Citations:    Fields:    Translation:Animals
  14. Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. J Med Chem. 2019 10 10; 62(19):8866-8872. PMID: 31518130.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S. Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease. ChemMedChem. 2019 09 04; 14(17):1580-1585. PMID: 31365783.
    Citations: 3     Fields:    Translation:HumansAnimals
  16. Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J. Author Correction: Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun. 2019 Apr 18; 10(1):1867. PMID: 31000704.
    Citations:    Fields:    
  17. Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. J Med Chem. 2019 04 11; 62(7):3336-3353. PMID: 30829483.
    Citations: 6     Fields:    Translation:Animals
  18. Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem Neurosci. 2019 05 15; 10(5):2263-2275. PMID: 30698943.
    Citations: 1     Fields:    Translation:Animals
  19. Deng X, Rong J, Wang L, Vasdev N, Zhang L, Josephson L, Liang SH. Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions. Angew Chem Int Ed Engl. 2019 02 25; 58(9):2580-2605. PMID: 30054961.
    Citations: 42     Fields:    Translation:Humans
  20. Shao T, Josephson L, Liang SH. PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease. Mol Imaging. 2019 Jan-Dec; 18:1536012119871455. PMID: 31478458.
    Citations:    Fields:    Translation:Humans
  21. Deng X, Hatori A, Chen Z, Kumata K, Shao T, Zhang X, Yamasaki T, Hu K, Yu Q, Ma L, Wang G, Wang L, Shao Y, Josephson L, Sun S, Zhang MR, Liang S. Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4. ChemMedChem. 2019 02 05; 14(3):303-309. PMID: 30589226.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Fu H, Chen Z, Josephson L, Li Z, Liang SH. Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors. J Med Chem. 2019 01 24; 62(2):403-419. PMID: 30110164.
    Citations: 10     Fields:    Translation:HumansAnimals
  23. Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH. Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging ?8-dependent transmembrane AMPA receptor regulatory protein. Eur J Med Chem. 2018 Sep 05; 157:898-908. PMID: 30145376.
    Citations: 4     Fields:    Translation:HumansCells
  24. Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE. Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation. Circ Cardiovasc Imaging. 2018 03; 11(3):e007007. PMID: 29555834.
    Citations: 3     Fields:    Translation:Animals
  25. Yuan H, Wilks MQ, Normandin MD, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nat Protoc. 2018 02; 13(2):392-412. PMID: 29370158.
    Citations: 12     Fields:    Translation:HumansAnimals
  26. Josephson L, Stratman N, Liu Y, Qian F, Liang SH, Vasdev N, Patel S. The Binding of BF-227-Like Benzoxazoles to Human a-Synuclein and Amyloid ß Peptide Fibrils. Mol Imaging. 2018 Jan-Dec; 17:1536012118796297. PMID: 30213230.
    Citations:    Fields:    Translation:HumansCells
  27. Narayanaswami V, Dahl K, Bernard-Gauthier V, Josephson L, Cumming P, Vasdev N. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO. Mol Imaging. 2018 Jan-Dec; 17:1536012118792317. PMID: 30203712.
    Citations: 39     Fields:    Translation:HumansAnimals
  28. Klein OJ, Yuan H, Nowell NH, Kaittanis C, Josephson L, Evans CL. An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy. Sci Rep. 2017 10 17; 7(1):13375. PMID: 29042620.
    Citations: 3     Fields:    Translation:HumansCells
  29. Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS One. 2017; 12(2):e0172722. PMID: 28225818.
    Citations: 8     Fields:    
  30. Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE. Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury. Theranostics. 2017; 7(4):814-825. PMID: 28382156.
    Citations: 5     Fields:    Translation:Animals
  31. Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13002-6. PMID: 26368132.
    Citations: 12     Fields:    Translation:AnimalsCells
  32. Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9. PMID: 25971846.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. EJNMMI Phys. 2015 Dec; 2(1):6. PMID: 26501808.
    Citations: 6     
  34. Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L. Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug. Nanoscale. 2015 Feb 14; 7(6):2255-9. PMID: 25572921.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. van Oosterom MN, Kreuger R, Buckle T, Mahn WA, Bunschoten A, Josephson L, van Leeuwen FW, Beekman FJ. U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform. EJNMMI Res. 2014; 4:56. PMID: 25386389.
    Citations: 4     
  36. Boros E, Bowen AM, Josephson L, Vasdev N, Holland JP. Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles. Chem Sci. 2015 Jan 01; 6(1):225-236. PMID: 28553472.
    Citations: 23     
  37. Habibollahi P, Waldron T, Heidari P, Cho HS, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U. Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation in Esophageal Dysplasia. Mol Imaging. 2014 May 01; 13(3):7290201400003. PMID: 28650303.
  38. Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. PLoS One. 2014; 9(4):e95406. PMID: 24781778.
    Citations: 3     Fields:    Translation:AnimalsCells
  39. Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun. 2014 Mar 04; 5:3384. PMID: 24594970.
    Citations: 31     Fields:    
  40. Habibollahi P, Waldron T, Heidari P, Cho HS, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U. Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia. Mol Imaging. 2014; 13:1-11. PMID: 24824854.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb). 2013 Nov 14; 49(88):10361-3. PMID: 24072060.
    Citations: 15     Fields:    
  42. Cho H, Guo Y, Sosnovik DE, Josephson L. Imaging DNA with fluorochrome bearing metals. Inorg Chem. 2013 Nov 04; 52(21):12216-22. PMID: 23646914.
    Citations: 2     Fields:    Translation:HumansAnimals
  43. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 01; 6(3):441-7. PMID: 23537953.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High efficiency diffusion molecular retention tumor targeting. PLoS One. 2013; 8(3):e58290. PMID: 23505478.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  45. Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26; 7(3):2032-41. PMID: 23373524.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  46. Josephson L, Rudin M. Barriers to clinical translation with diagnostic drugs. J Nucl Med. 2013 Mar; 54(3):329-32. PMID: 23359658.
    Citations: 11     Fields:    Translation:Humans
  47. Buckle T, Kuil J, van den Berg NS, Bunschoten A, Lamb HJ, Yuan H, Josephson L, Jonkers J, Borowsky AD, van Leeuwen FW. Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS. PLoS One. 2013; 8(1):e48324. PMID: 23326303.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  48. Guo Y, Yuan H, Rice WL, Kumar AT, Goergen CJ, Jokivarsi K, Josephson L. The PEG-fluorochrome shielding approach for targeted probe design. J Am Chem Soc. 2012 Nov 28; 134(47):19338-41. PMID: 23137147.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  49. Pelaz B, Jaber S, de Aberasturi DJ, Wulf V, Aida T, de la Fuente JM, Feldmann J, Gaub HE, Josephson L, Kagan CR, Kotov NA, Liz-Marzán LM, Mattoussi H, Mulvaney P, Murray CB, Rogach AL, Weiss PS, Willner I, Parak WJ. The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges. ACS Nano. 2012 Oct 23; 6(10):8468-83. PMID: 23016700.
    Citations: 24     Fields:    
  50. Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L. Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angew Chem Int Ed Engl. 2012 Jul 09; 51(28):6904-7. PMID: 22684680.
    Citations: 8     Fields:    
  51. Bunschoten A, Buckle T, Visser NL, Kuil J, Yuan H, Josephson L, Vahrmeijer AL, van Leeuwen FW. Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting avß3 integrin. Chembiochem. 2012 May 07; 13(7):1039-45. PMID: 22505018.
    Citations: 13     Fields:    Translation:Animals
  52. Chin PT, Beekman CA, Buckle T, Josephson L, van Leeuwen FW. Multispectral visualization of surgical safety-margins using fluorescent marker seeds. Am J Nucl Med Mol Imaging. 2012; 2(2):151-62. PMID: 23133810.
    Citations: 14     
  53. Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2012; 2(2):148-55. PMID: 22400062.
    Citations: 4     Fields:    
  54. Kuil J, Buckle T, Oldenburg J, Yuan H, Borowsky AD, Josephson L, van Leeuwen FW. Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression. Mol Pharm. 2011 Dec 05; 8(6):2444-53. PMID: 22085282.
    Citations: 17     Fields:    Translation:HumansCells
  55. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081.
    Citations: 26     Fields:    Translation:AnimalsCells
  56. Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, Rodig S, Ross RW, Josephson L, Weissleder R, Kelly KA. Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomed Nanotechnol. 2011 Aug; 2(112). PMID: 22319675.
    Citations: 7     
  57. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8. PMID: 21704591.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  58. Kuil J, Buckle T, Yuan H, van den Berg NS, Oishi S, Fujii N, Josephson L, van Leeuwen FW. Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide. Bioconjug Chem. 2011 May 18; 22(5):859-64. PMID: 21480671.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  59. Shao F, Yuan H, Josephson L, Weissleder R, Hilderbrand SA. Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores. Dyes Pigm. 2011 Apr 01; 90(2):119-122. PMID: 21475610.
    Citations: 13     
  60. Chen S, Alcantara D, Josephson L. A magnetofluorescent nanoparticle for ex-vivo cell labeling by covalently linking the drugs protamine and Feraheme. J Nanosci Nanotechnol. 2011 Apr; 11(4):3058-64. PMID: 21776671.
    Citations: 12     Fields:    Translation:AnimalsCells
  61. Chen HH, Josephson L, Sosnovik DE. Imaging of apoptosis in the heart with nanoparticle technology. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb; 3(1):86-99. PMID: 20945336.
    Citations: 6     Fields:    Translation:HumansAnimals
  62. Blois J, Smith A, Josephson L. The slow cell death response when screening chemotherapeutic agents. Cancer Chemother Pharmacol. 2011 Sep; 68(3):795-803. PMID: 21193989.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  63. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15. PMID: 20937980.
    Citations: 52     Fields:    Translation:AnimalsCells
  64. Garanger E, Blois J, Hilderbrand SA, Shao F, Josephson L. Divergent oriented synthesis for the design of reagents for protein conjugation. J Comb Chem. 2010 Jan-Feb; 12(1):57-64. PMID: 19928910.
    Citations: 9     Fields:    Translation:Cells
  65. Sheth RA, Josephson L, Mahmood U. Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography. J Biomed Opt. 2009 Nov-Dec; 14(6):064014. PMID: 20059252.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  66. Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L. A wortmannin-cetuximab as a double drug. Bioconjug Chem. 2009 Nov; 20(11):2185-9. PMID: 19883074.
    Citations:    Fields:    Translation:HumansCells
  67. Koh I, Josephson L. Magnetic nanoparticle sensors. Sensors (Basel). 2009; 9(10):8130-45. PMID: 22408498.
    Citations: 33     Fields:    
  68. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7. PMID: 19920044.
    Citations: 40     Fields:    Translation:AnimalsCells
  69. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  70. Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009 Aug; 60(8):2314-24. PMID: 19644878.
    Citations: 7     Fields:    Translation:AnimalsCells
  71. Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb). 2009 Aug 07; (29):4444-6. PMID: 19597620.
    Citations: 16     Fields:    Translation:Cells
  72. Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. . 2009 Jun; 8(6):1666-75. PMID: 19509266.
    Citations: 11     Translation:HumansAnimalsCells
  73. Sheth RA, Tam JM, Maricevich MA, Josephson L, Mahmood U. Quantitative endovascular fluorescence-based molecular imaging through blood of arterial wall inflammation. Radiology. 2009 Jun; 251(3):813-21. PMID: 19474377.
    Citations: 6     Fields:    Translation:Animals
  74. Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4223-7. PMID: 19523825.
    Citations: 4     Fields:    Translation:Animals
  75. Salthouse CD, Reynolds F, Tam JM, Josephson L, Mahmood U. Quantitative Measurement of Protease-Activity with Correction of Probe Delivery and Tissue Absorption Effects. Sens Actuators B Chem. 2009 May 06; 138(2):591-597. PMID: 20161242.
    Citations: 4     
  76. Koh I, Hong R, Weissleder R, Josephson L. Nanoparticle-target interactions parallel antibody-protein interactions. Anal Chem. 2009 May 01; 81(9):3618-22. PMID: 19323458.
    Citations: 12     Fields:    Translation:AnimalsCells
  77. Islam T, Josephson L. Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles. Cancer Biomark. 2009; 5(2):99-107. PMID: 19414927.
    Citations: 21     Fields:    Translation:Humans
  78. Garanger E, Weissleder R, Josephson L. A multifunctional single-attachment-point reagent for controlled protein biotinylation. Bioconjug Chem. 2009 Jan; 20(1):170-3. PMID: 19072220.
    Citations: 2     Fields:    Translation:Cells
  79. Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008 Dec; 118(12):4058-66. PMID: 19033674.
    Citations: 41     Fields:    Translation:AnimalsCells
  80. Perez JM, Grimm J, Josephson L, Weissleder R. Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia. 2008 Oct; 10(10):1066-72. PMID: 18813356.
    Citations: 14     Fields:    Translation:HumansCells
  81. Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L. Simplified syntheses of complex multifunctional nanomaterials. Chem Commun (Camb). 2008 Oct 21; (39):4792-4. PMID: 18830495.
    Citations: 16     Fields:    Translation:Cells
  82. Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U. Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology. 2008 Sep; 248(3):925-35. PMID: 18647846.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  83. Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. J Med Chem. 2008 Aug 14; 51(15):4699-707. PMID: 18630894.
    Citations: 7     Fields:    Translation:HumansCells
  84. Taktak S, Weissleder R, Josephson L. Electrode chemistry yields a nanoparticle-based NMR sensor for calcium. Langmuir. 2008 Jul 15; 24(14):7596-8. PMID: 18558729.
    Citations: 6     Fields:    Translation:Cells
  85. Hong R, Cima MJ, Weissleder R, Josephson L. Magnetic microparticle aggregation for viscosity determination by MR. Magn Reson Med. 2008 Mar; 59(3):515-20. PMID: 18306403.
    Citations: 9     Fields:    
  86. Koh I, Hong R, Weissleder R, Josephson L. Sensitive NMR sensors detect antibodies to influenza. Angew Chem Int Ed Engl. 2008; 47(22):4119-21. PMID: 18428168.
    Citations: 20     Fields:    Translation:HumansCells
  87. Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U. Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment. Int J Cancer. 2007 Dec 01; 121(11):2492-500. PMID: 17683072.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  88. Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L. Fate of a bioactive fluorescent wortmannin derivative in cells. Bioconjug Chem. 2008 Jan; 19(1):130-7. PMID: 17988080.
    Citations: 10     Fields:    Translation:HumansCells
  89. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007 Dec 01; 79(23):8863-9. PMID: 17983206.
    Citations: 18     Fields:    
  90. Kim GY, Josephson L, Langer R, Cima MJ. Magnetic relaxation switch detection of human chorionic gonadotrophin. Bioconjug Chem. 2007 Nov-Dec; 18(6):2024-8. PMID: 17892270.
    Citations: 15     Fields:    Translation:Humans
  91. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91. PMID: 17339546.
    Citations: 81     Fields:    Translation:AnimalsCells
  92. Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L. Covalent reactions of wortmannin under physiological conditions. Chem Biol. 2007 Mar; 14(3):321-8. PMID: 17379147.
    Citations: 16     Fields:    Translation:Cells
  93. Montet-Abou K, Montet X, Weissleder R, Josephson L. Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging. 2007 Jan-Feb; 6(1):1-9. PMID: 17311760.
    Citations: 21     Fields:    Translation:AnimalsCells
  94. Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L. Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006 Oct 05; 49(20):6087-93. PMID: 17004722.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  95. Sun EY, Weissleder R, Josephson L. Continuous analyte sensing with magnetic nanoswitches. Small. 2006 Oct; 2(10):1144-7. PMID: 17193579.
    Citations: 18     Fields:    Translation:Cells
  96. Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006 Jul-Aug; 17(4):905-11. PMID: 16848396.
    Citations: 43     Fields:    Translation:HumansCells
  97. Montet X, Yuan H, Weissleder R, Josephson L. Enzyme-based visualization of receptor-ligand binding in tissues. Lab Invest. 2006 May; 86(5):517-25. PMID: 16568109.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  98. Sun EY, Josephson L, Weissleder R. "Clickable" nanoparticles for targeted imaging. Mol Imaging. 2006 Apr-Jun; 5(2):122-8. PMID: 16954026.
    Citations: 26     Fields:    Translation:AnimalsCells
  99. Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia. 2006 Apr; 8(4):302-11. PMID: 16756722.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  100. Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia. 2006 Mar; 8(3):214-22. PMID: 16611415.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  101. Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. J Med Chem. 2006 Jan 26; 49(2):740-7. PMID: 16420059.
    Citations: 11     Fields:    
  102. Sun EY, Josephson L, Kelly KA, Weissleder R. Development of nanoparticle libraries for biosensing. Bioconjug Chem. 2006 Jan-Feb; 17(1):109-13. PMID: 16417258.
    Citations: 22     Fields:    
  103. Pittet MJ, Swirski FK, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006; 1(1):73-9. PMID: 17406214.
    Citations: 49     Fields:    Translation:AnimalsCells
  104. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol. 2005 Nov; 23(11):1418-23. PMID: 16244656.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  105. Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L. Nanoparticles for the optical imaging of tumor E-selectin. Neoplasia. 2005 Oct; 7(10):904-11. PMID: 16242073.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  106. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. PMID: 16086367.
    Citations: 78     Fields:    Translation:AnimalsCells
  107. Reynolds F, Weissleder R, Josephson L. Protamine as an efficient membrane-translocating peptide. Bioconjug Chem. 2005 Sep-Oct; 16(5):1240-5. PMID: 16173804.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  108. Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol Imaging. 2005 Jul-Sep; 4(3):165-71. PMID: 16194448.
    Citations: 15     Fields:    Translation:HumansCells
  109. Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75. PMID: 15898736.
    Citations: 6     Fields:    Translation:Cells
  110. Mahmood U, Josephson L. Molecular MR Imaging Probes. Proc IEEE Inst Electr Electron Eng. 2005 Apr; 93(4):800-808. PMID: 19194516.
  111. Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L. Transport of surface-modified nanoparticles through cell monolayers. Chembiochem. 2005 Feb; 6(2):337-45. PMID: 15651046.
    Citations: 16     Fields:    Translation:HumansCells
  112. Reynolds F, O'loughlin T, Weissleder R, Josephson L. Method of determining nanoparticle core weight. Anal Chem. 2005 Feb 01; 77(3):814-7. PMID: 15679348.
    Citations: 23     Fields:    
  113. Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res. 2005 Feb 18; 96(3):327-36. PMID: 15653572.
    Citations: 138     Fields:    Translation:AnimalsCells
  114. Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V. Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol. 2005; 27(3):183-90. PMID: 16037639.
    Citations: 5     Fields:    Translation:AnimalsCells
  115. Wunder A, Schellenberger E, Mahmood U, Bogdanov A, Müller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis. Mol Imaging. 2005 Jan-Mar; 4(1):1-6. PMID: 15967121.
    Citations: 4     Fields:    Translation:Animals
  116. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjug Chem. 2004 Sep-Oct; 15(5):1062-7. PMID: 15366960.
    Citations: 49     Fields:    Translation:HumansCells
  117. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A, Josephson L, Weissleder R. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12294-9. PMID: 15304657.
    Citations: 81     Fields:    Translation:Animals
  118. Kelly KA, Reynolds F, Weissleder R, Josephson L. Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal Biochem. 2004 Jul 15; 330(2):181-5. PMID: 15203322.
    Citations: 5     Fields:    Translation:HumansCells
  119. Schellingerhout D, Josephson L. Molecular imaging of cell-based therapies. Neuroimaging Clin N Am. 2004 May; 14(2):331-42, ix. PMID: 15182822.
    Citations:    Fields:    Translation:HumansAnimals
  120. Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L. Magnetic relaxation switch immunosensors detect enantiomeric impurities. Angew Chem Int Ed Engl. 2004 Apr 26; 43(18):2395-9. PMID: 15114571.
    Citations: 17     Fields:    Translation:CellsPHPublic Health
  121. Schellenberger EA, Reynolds F, Weissleder R, Josephson L. Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem. 2004 Mar 05; 5(3):275-9. PMID: 14997519.
    Citations: 16     Fields:    Translation:HumansCells
  122. Perez JM, Josephson L, Weissleder R. Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chembiochem. 2004 Mar 05; 5(3):261-4. PMID: 14997516.
    Citations: 43     Fields:    Translation:Cells
  123. Schellenberger EA, Weissleder R, Josephson L. Optimal modification of annexin V with fluorescent dyes. Chembiochem. 2004 Mar 05; 5(3):271-4. PMID: 14997518.
    Citations: 23     Fields:    Translation:Cells
  124. Kircher MF, Weissleder R, Josephson L. A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004 Mar-Apr; 15(2):242-8. PMID: 15025519.
    Citations: 28     Fields:    Translation:AnimalsCells
  125. Grimm J, Perez JM, Josephson L, Weissleder R. Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004 Jan 15; 64(2):639-43. PMID: 14744779.
    Citations: 25     Fields:    Translation:HumansCells
  126. Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003 Dec 01; 63(23):8122-5. PMID: 14678964.
    Citations: 127     Fields:    Translation:AnimalsCells
  127. Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L. Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem. 2003 Nov-Dec; 14(6):1115-21. PMID: 14624624.
    Citations: 38     Fields:    Translation:HumansCells
  128. Högemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003 Nov-Dec; 5(6):495-506. PMID: 14965443.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  129. Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15; 63(20):6838-46. PMID: 14583481.
    Citations: 112     Fields:    Translation:AnimalsCells
  130. Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc. 2003 Aug 27; 125(34):10192-3. PMID: 12926940.
    Citations: 50     Fields:    Translation:HumansCells
  131. Schellenberger EA, Bogdanov A, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003 May-Jun; 5(3):187-92. PMID: 12869301.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  132. Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A. Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003 Apr 15; 63(8):1936-42. PMID: 12702586.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  133. Zhao M, Josephson L, Tang Y, Weissleder R. Magnetic sensors for protease assays. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1375-8. PMID: 12671972.
    Citations: 29     Fields:    Translation:HumansCells
  134. Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R. Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging. 2003 Jan; 2(1):18-23. PMID: 12926234.
    Citations: 11     Fields:    Translation:Animals
  135. Wunderbaldinger P, Josephson L, Weissleder R. Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol. 2002 Aug; 9 Suppl 2:S304-6. PMID: 12188255.
    Citations: 47     Fields:    Translation:Animals
  136. Schellenberger EA, Högemann D, Josephson L, Weissleder R. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol. 2002 Aug; 9 Suppl 2:S310-1. PMID: 12188257.
    Citations: 11     Fields:    
  137. Perez JM, Josephson L, O'Loughlin T, Högemann D, Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002 Aug; 20(8):816-20. PMID: 12134166.
    Citations: 171     Fields:    Translation:HumansCells
  138. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002 Jul-Aug; 13(4):840-4. PMID: 12121140.
    Citations: 57     Fields:    Translation:AnimalsCells
  139. Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002 May-Jun; 13(3):554-60. PMID: 12009946.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  140. Kircher MF, Josephson L, Weissleder R. Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002 Apr-Jun; 1(2):89-95. PMID: 12920849.
    Citations: 8     Fields:    Translation:AnimalsCells
  141. Schellenberger EA, Bogdanov A, Högemann D, Tait J, Weissleder R, Josephson L. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002 Apr-Jun; 1(2):102-7. PMID: 12920851.
    Citations: 32     Fields:    Translation:HumansCells
  142. Perez JM, O'Loughin T, Simeone FJ, Weissleder R, Josephson L. DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002 Mar 27; 124(12):2856-7. PMID: 11902860.
    Citations: 40     Fields:    
  143. Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002 Mar-Apr; 13(2):264-8. PMID: 11906263.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  144. Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002 Feb; 47(2):292-7. PMID: 11810672.
    Citations: 29     Fields:    Translation:AnimalsCells
  145. Högemann D, Ntziachristos V, Josephson L, Weissleder R. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002 Jan-Feb; 13(1):116-21. PMID: 11792186.
    Citations: 17     Fields:    Translation:Cells
  146. Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002 Jan-Feb; 13(1):122-7. PMID: 11792187.
    Citations: 42     Fields:    Translation:HumansCells
  147. Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD. Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods. 2001 Oct 01; 256(1-2):89-105. PMID: 11516758.
    Citations: 42     Fields:    Translation:AnimalsCells
  148. Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R. Human transferrin receptor gene as a marker gene for MR imaging. Radiology. 2001 Oct; 221(1):244-50. PMID: 11568347.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  149. Josephson L, Perez JM, Weissleder R. Magnetic Nanosensors for the Detection of Oligonucleotide Sequences. Angew Chem Int Ed Engl. 2001 Sep 03; 40(17):3204-3206. PMID: 29712059.
    Citations: 11     Fields:    
  150. Högemann D, Josephson L, Weissleder R, Basilion JP. Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug Chem. 2000 Nov-Dec; 11(6):941-6. PMID: 11087345.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  151. Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem. 1999 Mar-Apr; 10(2):186-91. PMID: 10077466.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  152. Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990 May; 175(2):494-8. PMID: 2326475.
    Citations: 85     Fields:    Translation:Animals
  153. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990 May; 175(2):489-93. PMID: 2326474.
    Citations: 167     Fields:    Translation:AnimalsCells
  154. Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT. Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989 Jun; 171(3):835-9. PMID: 2717761.
    Citations: 10     Fields:    Translation:Animals
  155. Cantley LC, Cantley LG, Josephson L. A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem. 1978 Oct 25; 253(20):7361-8. PMID: 212422.
    Citations: 112     Fields:    Translation:AnimalsCells
  156. Cantley LC, Gelles J, Josephson L. Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. Biochemistry. 1978 Feb 07; 17(3):418-25. PMID: 145873.
    Citations: 8     Fields:    Translation:AnimalsCells
  157. Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10; 252(21):7421-3. PMID: 144127.
    Citations: 143     Fields:    Translation:Animals
  158. Josephson L, Cantley LC. Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. Biochemistry. 1977 Oct 18; 16(21):4572-8. PMID: 143955.
    Citations: 36     Fields:    Translation:Animals
  159. Cantley LC, Josephson L. A slow interconversion between active and inactive states of the (Na-K)ATPase. Biochemistry. 1976 Nov 30; 15(24):5280-7. PMID: 136980.
    Citations: 4     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.