Harvard Catalyst Profiles

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Lee Josephson, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EB017699 (NORMANDIN, MARC DAVID) Sep 22, 2014 - May 31, 2019
    NIH
    PEG-like Multimodal Nanoprobes for Imaging Enhanced Permeability Retention
    Role: Co-Principal Investigator
  2. R01EB011996 (JOSEPHSON, LEE) Jul 15, 2010 - Jul 30, 2014
    NIH
    Multimodal Vital Fluorochromes for Imaging
    Role: Principal Investigator
  3. R01EB009691 (JOSEPHSON, LEE) Jul 1, 2009 - Jun 30, 2013
    NIH
    Reagents for the Design of Targeted Multifunctional Nanomaterials
    Role: Principal Investigator
  4. R01EB004472 (JOSEPHSON, LEE) Sep 15, 2005 - Jun 30, 2010
    NIH
    Imaging of Pharmacotherapy Induced Apoptosis
    Role: Principal Investigator
  5. R01EB000662 (JOSEPHSON, LEE) Sep 15, 2002 - Aug 31, 2007
    NIH
    High Thoroughput Development of Molecular Imaging Agents
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen Z, Chen J, Chen L, Yoo CH, Rong J, Fu H, Shao T, Coffman K, Steyn SJ, Davenport AT, Daunais JB, Haider A, Collier L, Josephson L, Wey HY, Zhang L, Liang SH. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. PMID: 36256881.
    Citations:    Fields:    
  2. Chen HH, Khatun Z, Wei L, Mekkaoui C, Patel D, Kim SJW, Boukhalfa A, Enoma E, Meng L, Chen YI, Kaikkonen L, Li G, Capen DE, Sahu P, Kumar ATN, Blanton RM, Yuan H, Das S, Josephson L, Sosnovik DE. A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence. Nat Biomed Eng. 2022 09; 6(9):1045-1056. PMID: 35817962; PMCID: PMC9492651.
    Citations:    Fields:    
  3. Cheng R, Fujinaga M, Yang J, Rong J, Haider A, Ogasawara D, Van RS, Shao T, Chen Z, Zhang X, Calderon Leon ER, Zhang Y, Mori W, Kumata K, Yamasaki T, Xie L, Sun S, Wang L, Ran C, Shao Y, Cravatt B, Josephson L, Zhang MR, Liang SH. A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network. Acta Pharmacol Sin. 2022 Nov; 43(11):3002-3010. PMID: 35513432; PMCID: PMC9622914.
    Citations:    Fields:    
  4. Shao T, Chen Z, Cheng R, Collier L, Josephson L, Chung RT, Liang SH. Preliminary evaluation of [11C]MAGL-0519 as a promising PET ligand for the diagnosis of Hepatocellular carcinoma. Bioorg Chem. 2022 03; 120:105620. PMID: 35051705.
    Citations:    Fields:    Translation:Humans
  5. Chen Z, Haider A, Chen J, Xiao Z, Gobbi L, Honer M, Grether U, Arnold SE, Josephson L, Liang SH. The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO. J Med Chem. 2021 12 23; 64(24):17656-17689. PMID: 34905377; PMCID: PMC9094091.
    Citations: 1     Fields:    Translation:HumansAnimals
  6. Deng X, Salgado-Polo F, Shao T, Xiao Z, Van R, Chen J, Rong J, Haider A, Shao Y, Josephson L, Perrakis A, Liang SH. Imaging Autotaxin In Vivo with 18F-Labeled Positron Emission Tomography Ligands. J Med Chem. 2021 10 28; 64(20):15053-15068. PMID: 34662125.
    Citations:    Fields:    Translation:AnimalsCells
  7. Shao T, Chen Z, Rong J, Belov V, Chen J, Jeyarajan A, Deng X, Fu H, Yu Q, Rwema SH, Lin W, Papisov M, Josephson L, Chung RT, Liang SH. [18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models. Acta Pharm Sin B. 2022 Jan; 12(1):308-315. PMID: 35127387; PMCID: PMC8799882.
    Citations:    
  8. Sun J, Xiao Z, Haider A, Gebhard C, Xu H, Luo HB, Zhang HT, Josephson L, Wang L, Liang SH. Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery. J Med Chem. 2021 06 10; 64(11):7083-7109. PMID: 34042442.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Chen Z, Mori W, Rong J, Schafroth MA, Shao T, Van RS, Ogasawara D, Yamasaki T, Hiraishi A, Hatori A, Chen J, Zhang Y, Hu K, Fujinaga M, Sun J, Yu Q, Collier TL, Shao Y, Cravatt BF, Josephson L, Zhang MR, Liang SH. Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping. Acta Pharm Sin B. 2021 Jun; 11(6):1686-1695. PMID: 34221877; PMCID: PMC8245801.
    Citations: 1     
  10. Knight AC, Varlow C, Zi T, Liang SH, Josephson L, Schmidt K, Patel S, Vasdev N. In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R. ACS Chem Neurosci. 2021 03 17; 12(6):998-1006. PMID: 33667059; PMCID: PMC9350903.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Gholami YH, Yuan H, Wilks MQ, Josephson L, El Fakhri G, Normandin MD, Kuncic Z. Positron annihilation localization by nanoscale magnetization. Sci Rep. 2020 11 20; 10(1):20262. PMID: 33219274.
    Citations: 1     Fields:    Translation:Humans
  12. Zhang L, Hu K, Shao T, Hou L, Zhang S, Ye W, Josephson L, Meyer JH, Zhang MR, Vasdev N, Wang J, Xu H, Wang L, Liang SH. Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharm Sin B. 2021 Feb; 11(2):373-393. PMID: 33643818.
    Citations: 18     
  13. Sun JY, Kumata K, Chen Z, Zhang YD, Chen JH, Hatori A, Fu HL, Rong J, Deng XY, Yamasaki T, Xie L, Hu K, Fujinaga M, Yu QZ, Shao T, Collier TL, Josephson L, Shao YH, Du YF, Wang L, Xu H, Zhang MR, Liang SH. Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators. Acta Pharmacol Sin. 2021 Mar; 42(3):491-498. PMID: 32661351; PMCID: PMC8027431.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Deng X, Zhang Y, Chen Z, Kumata K, Van R, Rong J, Shao T, Hatori A, Mori W, Yu Q, Hu K, Fujinaga M, Wey HY, Shao Y, Josephson L, Murtas G, Pollegioni L, Zhang MR, Liang S. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging. Bioorg Med Chem Lett. 2020 08 15; 30(16):127326. PMID: 32631531.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Chen Z, Chen J, Mast N, Rong J, Deng X, Shao T, Fu H, Yu Q, Sun J, Shao Y, Josephson L, Collier TL, Pikuleva I, Liang SH. Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [11C]CO2 fixation method. Bioorg Med Chem Lett. 2020 05 01; 30(9):127068. PMID: 32178974.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Shao T, Chen Z, Belov V, Wang X, Rwema SH, Kumar V, Fu H, Deng X, Rong J, Yu Q, Lang L, Lin W, Josephson L, Samir AE, Chen X, Chung RT, Liang SH. [18F]-Alfatide PET imaging of integrin avß3 for the non-invasive quantification of liver fibrosis. J Hepatol. 2020 07; 73(1):161-169. PMID: 32145257.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Gholami YH, Yuan H, Wilks MQ, Maschmeyer R, Normandin MD, Josephson L, El Fakhri G, Kuncic Z. A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging. Int J Nanomedicine. 2020; 15:1253-1266. PMID: 32161456; PMCID: PMC7049573.
    Citations: 4     Fields:    Translation:Humans
  18. Tam JM, Josephson L, Pilozzi AR, Huang X. A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D. Molecules. 2020 Jan 09; 25(2). PMID: 31936569.
    Citations: 3     Fields:    Translation:HumansCells
  19. Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. Int J Nanomedicine. 2020; 15:31-47. PMID: 32021163; PMCID: PMC6954846.
    Citations: 3     Fields:    
  20. Yu Q, Kumata K, Li H, Zhang Y, Chen Z, Zhang X, Shao T, Hatori A, Yamasaki T, Xie L, Hu K, Wang G, Josephson L, Sun S, Zhang MR, Liang SH. Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging ?-8 dependent transmembrane AMPA receptor regulatory protein by PET. Bioorg Med Chem Lett. 2020 02 15; 30(4):126879. PMID: 31879207.
    Citations:    Fields:    Translation:Animals
  21. Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. J Med Chem. 2019 10 10; 62(19):8866-8872. PMID: 31518130.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S. Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease. ChemMedChem. 2019 09 04; 14(17):1580-1585. PMID: 31365783.
    Citations: 4     Fields:    Translation:HumansAnimals
  23. Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J. Author Correction: Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun. 2019 Apr 18; 10(1):1867. PMID: 31000704.
    Citations: 1     Fields:    
  24. Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. J Med Chem. 2019 04 11; 62(7):3336-3353. PMID: 30829483; PMCID: PMC6581563.
    Citations: 9     Fields:    Translation:Animals
  25. Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem Neurosci. 2019 05 15; 10(5):2263-2275. PMID: 30698943; PMCID: PMC6727982.
    Citations: 2     Fields:    Translation:Animals
  26. Deng X, Rong J, Wang L, Vasdev N, Zhang L, Josephson L, Liang SH. Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions. Angew Chem Int Ed Engl. 2019 02 25; 58(9):2580-2605. PMID: 30054961; PMCID: PMC6405341.
    Citations: 60     Fields:    Translation:Humans
  27. Shao T, Josephson L, Liang SH. PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease. Mol Imaging. 2019 Jan-Dec; 18:1536012119871455. PMID: 31478458; PMCID: PMC6724487.
    Citations: 1     Fields:    Translation:Humans
  28. Deng X, Hatori A, Chen Z, Kumata K, Shao T, Zhang X, Yamasaki T, Hu K, Yu Q, Ma L, Wang G, Wang L, Shao Y, Josephson L, Sun S, Zhang MR, Liang S. Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4. ChemMedChem. 2019 02 05; 14(3):303-309. PMID: 30589226.
    Citations: 1     Fields:    Translation:AnimalsCells
  29. Fu H, Chen Z, Josephson L, Li Z, Liang SH. Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors. J Med Chem. 2019 01 24; 62(2):403-419. PMID: 30110164; PMCID: PMC6393217.
    Citations: 12     Fields:    Translation:HumansAnimals
  30. Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH. Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging ?8-dependent transmembrane AMPA receptor regulatory protein. Eur J Med Chem. 2018 Sep 05; 157:898-908. PMID: 30145376.
    Citations: 6     Fields:    Translation:HumansCells
  31. Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE. Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation. Circ Cardiovasc Imaging. 2018 03; 11(3):e007007. PMID: 29555834.
    Citations: 4     Fields:    Translation:Animals
  32. Yuan H, Wilks MQ, Normandin MD, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nat Protoc. 2018 02; 13(2):392-412. PMID: 29370158.
    Citations: 18     Fields:    Translation:HumansAnimals
  33. Narayanaswami V, Dahl K, Bernard-Gauthier V, Josephson L, Cumming P, Vasdev N. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO. Mol Imaging. 2018 Jan-Dec; 17:1536012118792317. PMID: 30203712; PMCID: PMC6134492.
    Citations: 54     Fields:    Translation:HumansAnimals
  34. Josephson L, Stratman N, Liu Y, Qian F, Liang SH, Vasdev N, Patel S. The Binding of BF-227-Like Benzoxazoles to Human a-Synuclein and Amyloid ß Peptide Fibrils. Mol Imaging. 2018 Jan-Dec; 17:1536012118796297. PMID: 30213230; PMCID: PMC6144582.
    Citations: 1     Fields:    Translation:HumansCells
  35. Klein OJ, Yuan H, Nowell NH, Kaittanis C, Josephson L, Evans CL. An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy. Sci Rep. 2017 10 17; 7(1):13375. PMID: 29042620.
    Citations: 4     Fields:    Translation:HumansCells
  36. Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS One. 2017; 12(2):e0172722. PMID: 28225818; PMCID: PMC5321420.
    Citations: 12     Fields:    
  37. Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE. Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury. Theranostics. 2017; 7(4):814-825. PMID: 28382156; PMCID: PMC5381246.
    Citations: 10     Fields:    Translation:Animals
  38. Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13002-6. PMID: 26368132; PMCID: PMC4754124.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug Chem. 2015 Jun 17; 26(6):1061-9. PMID: 25971846; PMCID: PMC5378316.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. EJNMMI Phys. 2015 Dec; 2(1):6. PMID: 26501808; PMCID: PMC4544618.
    Citations: 7     
  41. Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L. Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug. Nanoscale. 2015 Feb 14; 7(6):2255-9. PMID: 25572921; PMCID: PMC4312233.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  42. van Oosterom MN, Kreuger R, Buckle T, Mahn WA, Bunschoten A, Josephson L, van Leeuwen FW, Beekman FJ. U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform. EJNMMI Res. 2014; 4:56. PMID: 25386389; PMCID: PMC4209452.
    Citations: 5     
  43. Boros E, Bowen AM, Josephson L, Vasdev N, Holland JP. Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles. Chem Sci. 2015 Jan 01; 6(1):225-236. PMID: 28553472; PMCID: PMC5433050.
    Citations: 36     
  44. Habibollahi P, Waldron T, Heidari P, Cho HS, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U. Fluorescent Nanoparticle Imaging Allows Noninvasive Evaluation of Immune Cell Modulation in Esophageal Dysplasia. Mol Imaging. 2014 May 01; 13(3):7290201400003. PMID: 28650303.
    Citations:    
  45. Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. PLoS One. 2014; 9(4):e95406. PMID: 24781778.
    Citations: 3     Fields:    Translation:AnimalsCells
  46. Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat Commun. 2014 Mar 04; 5:3384. PMID: 24594970.
    Citations: 35     Fields:    
  47. Habibollahi P, Waldron T, Heidari P, Cho HS, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U. Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia. Mol Imaging. 2014; 13:1-11. PMID: 24824854.
    Citations: 5     Fields:    Translation:AnimalsCells
  48. Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb). 2013 Nov 14; 49(88):10361-3. PMID: 24072060.
    Citations: 16     Fields:    
  49. Cho H, Guo Y, Sosnovik DE, Josephson L. Imaging DNA with fluorochrome bearing metals. Inorg Chem. 2013 Nov 04; 52(21):12216-22. PMID: 23646914.
    Citations: 2     Fields:    Translation:HumansAnimals
  50. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 01; 6(3):441-7. PMID: 23537953.
    Citations: 17     Fields:    Translation:AnimalsCells
  51. Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High efficiency diffusion molecular retention tumor targeting. PLoS One. 2013; 8(3):e58290. PMID: 23505478.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  52. Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26; 7(3):2032-41. PMID: 23373524.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  53. Josephson L, Rudin M. Barriers to clinical translation with diagnostic drugs. J Nucl Med. 2013 Mar; 54(3):329-32. PMID: 23359658.
    Citations: 12     Fields:    Translation:Humans
  54. Buckle T, Kuil J, van den Berg NS, Bunschoten A, Lamb HJ, Yuan H, Josephson L, Jonkers J, Borowsky AD, van Leeuwen FW. Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS. PLoS One. 2013; 8(1):e48324. PMID: 23326303.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  55. Guo Y, Yuan H, Rice WL, Kumar AT, Goergen CJ, Jokivarsi K, Josephson L. The PEG-fluorochrome shielding approach for targeted probe design. J Am Chem Soc. 2012 Nov 28; 134(47):19338-41. PMID: 23137147.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  56. Pelaz B, Jaber S, de Aberasturi DJ, Wulf V, Aida T, de la Fuente JM, Feldmann J, Gaub HE, Josephson L, Kagan CR, Kotov NA, Liz-Marzán LM, Mattoussi H, Mulvaney P, Murray CB, Rogach AL, Weiss PS, Willner I, Parak WJ. The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges. ACS Nano. 2012 Oct 23; 6(10):8468-83. PMID: 23016700.
    Citations: 26     Fields:    
  57. Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L. Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angew Chem Int Ed Engl. 2012 Jul 09; 51(28):6904-7. PMID: 22684680.
    Citations: 8     Fields:    
  58. Bunschoten A, Buckle T, Visser NL, Kuil J, Yuan H, Josephson L, Vahrmeijer AL, van Leeuwen FW. Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting avß3 integrin. Chembiochem. 2012 May 07; 13(7):1039-45. PMID: 22505018.
    Citations: 14     Fields:    Translation:Animals
  59. Chin PT, Beekman CA, Buckle T, Josephson L, van Leeuwen FW. Multispectral visualization of surgical safety-margins using fluorescent marker seeds. Am J Nucl Med Mol Imaging. 2012; 2(2):151-62. PMID: 23133810.
    Citations: 14     
  60. Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2012; 2(2):148-55. PMID: 22400062.
    Citations: 4     Fields:    
  61. Kuil J, Buckle T, Oldenburg J, Yuan H, Borowsky AD, Josephson L, van Leeuwen FW. Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression. Mol Pharm. 2011 Dec 05; 8(6):2444-53. PMID: 22085282.
    Citations: 18     Fields:    Translation:HumansCells
  62. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081.
    Citations: 29     Fields:    Translation:AnimalsCells
  63. Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, Rodig S, Ross RW, Josephson L, Weissleder R, Kelly KA. Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomed Nanotechnol. 2011 Aug; 2(112). PMID: 22319675.
    Citations: 9     
  64. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8. PMID: 21704591.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  65. Kuil J, Buckle T, Yuan H, van den Berg NS, Oishi S, Fujii N, Josephson L, van Leeuwen FW. Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide. Bioconjug Chem. 2011 May 18; 22(5):859-64. PMID: 21480671.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  66. Shao F, Yuan H, Josephson L, Weissleder R, Hilderbrand SA. Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores. Dyes Pigm. 2011 Apr 01; 90(2):119-122. PMID: 21475610.
    Citations: 15     
  67. Chen S, Alcantara D, Josephson L. A magnetofluorescent nanoparticle for ex-vivo cell labeling by covalently linking the drugs protamine and Feraheme. J Nanosci Nanotechnol. 2011 Apr; 11(4):3058-64. PMID: 21776671.
    Citations: 12     Fields:    Translation:AnimalsCells
  68. Chen HH, Josephson L, Sosnovik DE. Imaging of apoptosis in the heart with nanoparticle technology. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb; 3(1):86-99. PMID: 20945336.
    Citations: 8     Fields:    Translation:HumansAnimals
  69. Blois J, Smith A, Josephson L. The slow cell death response when screening chemotherapeutic agents. Cancer Chemother Pharmacol. 2011 Sep; 68(3):795-803. PMID: 21193989.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  70. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15. PMID: 20937980; PMCID: PMC3003265.
    Citations: 63     Fields:    Translation:AnimalsCells
  71. Garanger E, Blois J, Hilderbrand SA, Shao F, Josephson L. Divergent oriented synthesis for the design of reagents for protein conjugation. J Comb Chem. 2010 Jan-Feb; 12(1):57-64. PMID: 19928910.
    Citations: 9     Fields:    Translation:Cells
  72. Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L. A wortmannin-cetuximab as a double drug. Bioconjug Chem. 2009 Nov; 20(11):2185-9. PMID: 19883074.
    Citations:    Fields:    Translation:HumansCells
  73. Sheth RA, Josephson L, Mahmood U. Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography. J Biomed Opt. 2009 Nov-Dec; 14(6):064014. PMID: 20059252.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  74. Koh I, Josephson L. Magnetic nanoparticle sensors. Sensors (Basel). 2009; 9(10):8130-45. PMID: 22408498.
    Citations: 42     Fields:    
  75. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7. PMID: 19920044.
    Citations: 43     Fields:    Translation:AnimalsCells
  76. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  77. Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009 Aug; 60(8):2314-24. PMID: 19644878; PMCID: PMC3080016.
    Citations: 7     Fields:    Translation:AnimalsCells
  78. Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb). 2009 Aug 07; (29):4444-6. PMID: 19597620.
    Citations: 17     Fields:    Translation:Cells
  79. Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009 Jun; 8(6):1666-75. PMID: 19509266.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  80. Sheth RA, Tam JM, Maricevich MA, Josephson L, Mahmood U. Quantitative endovascular fluorescence-based molecular imaging through blood of arterial wall inflammation. Radiology. 2009 Jun; 251(3):813-21. PMID: 19474377; PMCID: PMC2687531.
    Citations: 6     Fields:    Translation:Animals
  81. Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4223-7. PMID: 19523825.
    Citations: 4     Fields:    Translation:Animals
  82. Salthouse CD, Reynolds F, Tam JM, Josephson L, Mahmood U. Quantitative Measurement of Protease-Activity with Correction of Probe Delivery and Tissue Absorption Effects. Sens Actuators B Chem. 2009 May 06; 138(2):591-597. PMID: 20161242.
    Citations: 4     
  83. Koh I, Hong R, Weissleder R, Josephson L. Nanoparticle-target interactions parallel antibody-protein interactions. Anal Chem. 2009 May 01; 81(9):3618-22. PMID: 19323458.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Islam T, Josephson L. Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles. Cancer Biomark. 2009; 5(2):99-107. PMID: 19414927.
    Citations: 25     Fields:    Translation:Humans
  85. Garanger E, Weissleder R, Josephson L. A multifunctional single-attachment-point reagent for controlled protein biotinylation. Bioconjug Chem. 2009 Jan; 20(1):170-3. PMID: 19072220.
    Citations: 2     Fields:    Translation:Cells
  86. Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008 Dec; 118(12):4058-66. PMID: 19033674; PMCID: PMC2579705.
    Citations: 42     Fields:    Translation:AnimalsCells
  87. Perez JM, Grimm J, Josephson L, Weissleder R. Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia. 2008 Oct; 10(10):1066-72. PMID: 18813356; PMCID: PMC2546593.
    Citations: 14     Fields:    Translation:HumansCells
  88. Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L. Simplified syntheses of complex multifunctional nanomaterials. Chem Commun (Camb). 2008 Oct 21; (39):4792-4. PMID: 18830495; PMCID: PMC2692914.
    Citations: 17     Fields:    Translation:Cells
  89. Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U. Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology. 2008 Sep; 248(3):925-35. PMID: 18647846; PMCID: PMC2798096.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  90. Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. J Med Chem. 2008 Aug 14; 51(15):4699-707. PMID: 18630894.
    Citations: 7     Fields:    Translation:HumansCells
  91. Taktak S, Weissleder R, Josephson L. Electrode chemistry yields a nanoparticle-based NMR sensor for calcium. Langmuir. 2008 Jul 15; 24(14):7596-8. PMID: 18558729.
    Citations: 7     Fields:    Translation:Cells
  92. Hong R, Cima MJ, Weissleder R, Josephson L. Magnetic microparticle aggregation for viscosity determination by MR. Magn Reson Med. 2008 Mar; 59(3):515-20. PMID: 18306403.
    Citations: 11     Fields:    
  93. Koh I, Hong R, Weissleder R, Josephson L. Sensitive NMR sensors detect antibodies to influenza. Angew Chem Int Ed Engl. 2008; 47(22):4119-21. PMID: 18428168.
    Citations: 21     Fields:    Translation:HumansCells
  94. Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U. Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment. Int J Cancer. 2007 Dec 01; 121(11):2492-500. PMID: 17683072.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  95. Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L. Fate of a bioactive fluorescent wortmannin derivative in cells. Bioconjug Chem. 2008 Jan; 19(1):130-7. PMID: 17988080.
    Citations: 10     Fields:    Translation:HumansCells
  96. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007 Dec 01; 79(23):8863-9. PMID: 17983206.
    Citations: 20     Fields:    
  97. Kim GY, Josephson L, Langer R, Cima MJ. Magnetic relaxation switch detection of human chorionic gonadotrophin. Bioconjug Chem. 2007 Nov-Dec; 18(6):2024-8. PMID: 17892270.
    Citations: 15     Fields:    Translation:Humans
  98. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91. PMID: 17339546.
    Citations: 86     Fields:    Translation:AnimalsCells
  99. Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L. Covalent reactions of wortmannin under physiological conditions. Chem Biol. 2007 Mar; 14(3):321-8. PMID: 17379147.
    Citations: 18     Fields:    Translation:Cells
  100. Montet-Abou K, Montet X, Weissleder R, Josephson L. Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging. 2007 Jan-Feb; 6(1):1-9. PMID: 17311760.
    Citations: 21     Fields:    Translation:AnimalsCells
  101. Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L. Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006 Oct 05; 49(20):6087-93. PMID: 17004722.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  102. Sun EY, Weissleder R, Josephson L. Continuous analyte sensing with magnetic nanoswitches. Small. 2006 Oct; 2(10):1144-7. PMID: 17193579.
    Citations: 19     Fields:    Translation:Cells
  103. Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006 Jul-Aug; 17(4):905-11. PMID: 16848396.
    Citations: 44     Fields:    Translation:HumansCells
  104. Montet X, Yuan H, Weissleder R, Josephson L. Enzyme-based visualization of receptor-ligand binding in tissues. Lab Invest. 2006 May; 86(5):517-25. PMID: 16568109.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  105. Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia. 2006 Apr; 8(4):302-11. PMID: 16756722.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  106. Sun EY, Josephson L, Weissleder R. "Clickable" nanoparticles for targeted imaging. Mol Imaging. 2006 Apr-Jun; 5(2):122-8. PMID: 16954026.
    Citations: 26     Fields:    Translation:AnimalsCells
  107. Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia. 2006 Mar; 8(3):214-22. PMID: 16611415.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  108. Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. J Med Chem. 2006 Jan 26; 49(2):740-7. PMID: 16420059.
    Citations: 11     Fields:    
  109. Pittet MJ, Swirski FK, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006; 1(1):73-9. PMID: 17406214.
    Citations: 50     Fields:    Translation:AnimalsCells
  110. Sun EY, Josephson L, Kelly KA, Weissleder R. Development of nanoparticle libraries for biosensing. Bioconjug Chem. 2006 Jan-Feb; 17(1):109-13. PMID: 16417258.
    Citations: 23     Fields:    
  111. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol. 2005 Nov; 23(11):1418-23. PMID: 16244656.
    Citations: 251     Fields:    Translation:HumansAnimalsCells
  112. Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L. Nanoparticles for the optical imaging of tumor E-selectin. Neoplasia. 2005 Oct; 7(10):904-11. PMID: 16242073.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  113. Reynolds F, Weissleder R, Josephson L. Protamine as an efficient membrane-translocating peptide. Bioconjug Chem. 2005 Sep-Oct; 16(5):1240-5. PMID: 16173804.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  114. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. PMID: 16086367.
    Citations: 83     Fields:    Translation:AnimalsCells
  115. Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol Imaging. 2005 Jul-Sep; 4(3):165-71. PMID: 16194448.
    Citations: 16     Fields:    Translation:HumansCells
  116. Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75. PMID: 15898736.
    Citations: 6     Fields:    Translation:Cells
  117. Mahmood U, Josephson L. Molecular MR Imaging Probes. Proc IEEE Inst Electr Electron Eng. 2005 Apr; 93(4):800-808. PMID: 19194516.
    Citations:    
  118. Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L. Transport of surface-modified nanoparticles through cell monolayers. Chembiochem. 2005 Feb; 6(2):337-45. PMID: 15651046.
    Citations: 16     Fields:    Translation:HumansCells
  119. Reynolds F, O'loughlin T, Weissleder R, Josephson L. Method of determining nanoparticle core weight. Anal Chem. 2005 Feb 01; 77(3):814-7. PMID: 15679348.
    Citations: 26     Fields:    
  120. Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res. 2005 Feb 18; 96(3):327-36. PMID: 15653572.
    Citations: 147     Fields:    Translation:AnimalsCells
  121. Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V. Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol. 2005; 27(3):183-90. PMID: 16037639; PMCID: PMC4615174.
    Citations: 5     Fields:    Translation:AnimalsCells
  122. Wunder A, Schellenberger E, Mahmood U, Bogdanov A, Müller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis. Mol Imaging. 2005 Jan-Mar; 4(1):1-6. PMID: 15967121.
    Citations: 5     Fields:    Translation:Animals
  123. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjug Chem. 2004 Sep-Oct; 15(5):1062-7. PMID: 15366960.
    Citations: 50     Fields:    Translation:HumansCells
  124. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A, Josephson L, Weissleder R. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12294-9. PMID: 15304657; PMCID: PMC514472.
    Citations: 86     Fields:    Translation:Animals
  125. Kelly KA, Reynolds F, Weissleder R, Josephson L. Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal Biochem. 2004 Jul 15; 330(2):181-5. PMID: 15203322.
    Citations: 5     Fields:    Translation:HumansCells
  126. Schellingerhout D, Josephson L. Molecular imaging of cell-based therapies. Neuroimaging Clin N Am. 2004 May; 14(2):331-42, ix. PMID: 15182822.
    Citations:    Fields:    Translation:HumansAnimals
  127. Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L. Magnetic relaxation switch immunosensors detect enantiomeric impurities. Angew Chem Int Ed Engl. 2004 Apr 26; 43(18):2395-9. PMID: 15114571.
    Citations: 20     Fields:    Translation:CellsPHPublic Health
  128. Schellenberger EA, Weissleder R, Josephson L. Optimal modification of annexin V with fluorescent dyes. Chembiochem. 2004 Mar 05; 5(3):271-4. PMID: 14997518.
    Citations: 24     Fields:    Translation:Cells
  129. Schellenberger EA, Reynolds F, Weissleder R, Josephson L. Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem. 2004 Mar 05; 5(3):275-9. PMID: 14997519.
    Citations: 17     Fields:    Translation:HumansCells
  130. Perez JM, Josephson L, Weissleder R. Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chembiochem. 2004 Mar 05; 5(3):261-4. PMID: 14997516.
    Citations: 47     Fields:    Translation:Cells
  131. Kircher MF, Weissleder R, Josephson L. A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004 Mar-Apr; 15(2):242-8. PMID: 15025519.
    Citations: 28     Fields:    Translation:AnimalsCells
  132. Grimm J, Perez JM, Josephson L, Weissleder R. Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004 Jan 15; 64(2):639-43. PMID: 14744779.
    Citations: 29     Fields:    Translation:HumansCells
  133. Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003 Dec 01; 63(23):8122-5. PMID: 14678964.
    Citations: 133     Fields:    Translation:AnimalsCells
  134. Högemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003 Nov-Dec; 5(6):495-506. PMID: 14965443.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  135. Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L. Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem. 2003 Nov-Dec; 14(6):1115-21. PMID: 14624624.
    Citations: 38     Fields:    Translation:HumansCells
  136. Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15; 63(20):6838-46. PMID: 14583481.
    Citations: 123     Fields:    Translation:AnimalsCells
  137. Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc. 2003 Aug 27; 125(34):10192-3. PMID: 12926940.
    Citations: 60     Fields:    Translation:HumansCells
  138. Schellenberger EA, Bogdanov A, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003 May-Jun; 5(3):187-92. PMID: 12869301.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  139. Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A. Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003 Apr 15; 63(8):1936-42. PMID: 12702586.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  140. Zhao M, Josephson L, Tang Y, Weissleder R. Magnetic sensors for protease assays. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1375-8. PMID: 12671972.
    Citations: 30     Fields:    Translation:HumansCells
  141. Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R. Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging. 2003 Jan; 2(1):18-23. PMID: 12926234.
    Citations: 12     Fields:    Translation:Animals
  142. Wunderbaldinger P, Josephson L, Weissleder R. Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol. 2002 Aug; 9 Suppl 2:S304-6. PMID: 12188255.
    Citations: 50     Fields:    Translation:Animals
  143. Schellenberger EA, Högemann D, Josephson L, Weissleder R. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol. 2002 Aug; 9 Suppl 2:S310-1. PMID: 12188257.
    Citations: 11     Fields:    
  144. Perez JM, Josephson L, O'Loughlin T, Högemann D, Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002 Aug; 20(8):816-20. PMID: 12134166.
    Citations: 179     Fields:    Translation:HumansCells
  145. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002 Jul-Aug; 13(4):840-4. PMID: 12121140.
    Citations: 58     Fields:    Translation:AnimalsCells
  146. Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002 May-Jun; 13(3):554-60. PMID: 12009946.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  147. Kircher MF, Josephson L, Weissleder R. Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002 Apr-Jun; 1(2):89-95. PMID: 12920849.
    Citations: 8     Fields:    Translation:AnimalsCells
  148. Schellenberger EA, Bogdanov A, Högemann D, Tait J, Weissleder R, Josephson L. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002 Apr-Jun; 1(2):102-7. PMID: 12920851.
    Citations: 32     Fields:    Translation:HumansCells
  149. Perez JM, O'Loughin T, Simeone FJ, Weissleder R, Josephson L. DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002 Mar 27; 124(12):2856-7. PMID: 11902860.
    Citations: 42     Fields:    
  150. Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002 Mar-Apr; 13(2):264-8. PMID: 11906263.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  151. Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002 Feb; 47(2):292-7. PMID: 11810672.
    Citations: 30     Fields:    Translation:AnimalsCells
  152. Högemann D, Ntziachristos V, Josephson L, Weissleder R. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002 Jan-Feb; 13(1):116-21. PMID: 11792186.
    Citations: 17     Fields:    Translation:Cells
  153. Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002 Jan-Feb; 13(1):122-7. PMID: 11792187.
    Citations: 45     Fields:    Translation:HumansCells
  154. Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R. Human transferrin receptor gene as a marker gene for MR imaging. Radiology. 2001 Oct; 221(1):244-50. PMID: 11568347.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  155. Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD. Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods. 2001 Oct 01; 256(1-2):89-105. PMID: 11516758.
    Citations: 44     Fields:    Translation:AnimalsCells
  156. Josephson L, Perez JM, Weissleder R. Magnetic Nanosensors for the Detection of Oligonucleotide Sequences. Angew Chem Int Ed Engl. 2001 Sep 03; 40(17):3204-3206. PMID: 29712059.
    Citations: 46     Fields:    
  157. Högemann D, Josephson L, Weissleder R, Basilion JP. Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug Chem. 2000 Nov-Dec; 11(6):941-6. PMID: 11087345.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  158. Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem. 1999 Mar-Apr; 10(2):186-91. PMID: 10077466.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  159. Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990 May; 175(2):494-8. PMID: 2326475.
    Citations: 89     Fields:    Translation:Animals
  160. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990 May; 175(2):489-93. PMID: 2326474.
    Citations: 177     Fields:    Translation:AnimalsCells
  161. Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT. Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989 Jun; 171(3):835-9. PMID: 2717761.
    Citations: 10     Fields:    Translation:Animals
  162. Cantley LC, Cantley LG, Josephson L. A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem. 1978 Oct 25; 253(20):7361-8. PMID: 212422.
    Citations: 112     Fields:    Translation:AnimalsCells
  163. Cantley LC, Gelles J, Josephson L. Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. Biochemistry. 1978 Feb 07; 17(3):418-25. PMID: 145873.
    Citations: 8     Fields:    Translation:AnimalsCells
  164. Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10; 252(21):7421-3. PMID: 144127.
    Citations: 148     Fields:    Translation:Animals
  165. Josephson L, Cantley LC. Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. Biochemistry. 1977 Oct 18; 16(21):4572-8. PMID: 143955.
    Citations: 36     Fields:    Translation:Animals
  166. Cantley LC, Josephson L. A slow interconversion between active and inactive states of the (Na-K)ATPase. Biochemistry. 1976 Nov 30; 15(24):5280-7. PMID: 136980.
    Citations: 4     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.