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profileMatthew P. Frosch, M.D.,Ph.D.

TitleLawrence J. Henderson Associate Professor of Pathology and Health Sciences and Technology
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressMassachusetts General Hospital
Pathology/Neuropathology (Warren 334)
55 Fruit St
Boston MA 02114
Phone617/726-5156
Fax617/724-1813
vCardDownload vCard (login for email)
Other Positions
TitleAssociate Professor of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AG021084     (FROSCH, MATTHEW P)Sep 1, 2002 - Apr 30, 2012
NIH/NIA
Spatial and Temporal Progression of Amyloid Angiopathy
Role: Principal Investigator

P50NS038375     (LANSBURY, PETER T)Sep 30, 1999 - Aug 31, 2011
NIH/NINDS
Familial Parkinson's Disease: Clues to Pathogenesis
Role: Co-Principal Investigator

P01AG015379     (SELKOE, DENNIS J)Sep 30, 1998 - Jun 30, 2018
NIH/NIA
Presenilin Biology and the Mechanisms of Alzheimer's Disease
Role: Co-Principal Investigator

R03AG014870     (FROSCH, MATTHEW P)Jul 15, 1997 - Jun 30, 1999
NIH/NIA
PRESENILIN 1 TRANSGENIC MICE--ALZHEIMER DISEASE MODELS
Role: Principal Investigator

K08HL003168     (FROSCH, MATTHEW P)Sep 30, 1994 - Aug 31, 2000
NIH/NHLBI
NOVEL ENDOTHELIAL CELL CADHERIN LIKE MOLECULE
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Topcuoglu MA, Jha RM, George J, Frosch MP, Singhal AB. Hemorrhagic primary CNS angiitis and vasoconstrictive drug exposure. Neurol Clin Pract. 2017 Feb; 7(1):26-34. PMID: 28243503.
    View in: PubMed
  2. Mesulam MM, Dickerson BC, Sherman JC, Hochberg D, Gonzalez RG, Johnson KA, Frosch MP. Case 1-2017. A 70-Year-Old Woman with Gradually Progressive Loss of Language. N Engl J Med. 2017 01 12; 376(2):158-167. PMID: 28076711.
    View in: PubMed
  3. Ysselstein D, Dehay B, Costantino IM, McCabe GP, Frosch MP, George JM, Bezard E, Rochet JC. Endosulfine-alpha inhibits membrane-induced a-synuclein aggregation and protects against a-synuclein neurotoxicity. Acta Neuropathol Commun. 2017 Jan 10; 5(1):3. PMID: 28069058.
    View in: PubMed
  4. Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan; 81(1):117-128. PMID: 27997036.
    View in: PubMed
  5. Sellal F, Wallon D, Martinez-Almoyna L, Marelli C, Dhar A, Oesterlé H, Rovelet-Lecrux A, Rousseau S, Kourkoulis CE, Rosand J, DiPucchio ZY, Frosch M, Gombert C, Audoin B, Miné M, Riant F, Frebourg T, Hannequin D, Campion D, Greenberg SM, Tournier-Lasserve E, Nicolas G. APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review. J Alzheimers Dis. 2017; 56(1):37-46. PMID: 27858710.
    View in: PubMed
  6. Mitchell SB, Lucente D, Larvie M, Cobos MI, Frosch M, Dickerson BC. A 63-Year-Old Man With Progressive Visual Symptoms. JAMA Neurol. 2017 Jan 01; 74(1):114-118. PMID: 27842190.
    View in: PubMed
  7. Troncone L, Luciani M, Coggins M, Wilker EH, Ho CY, Codispoti KE, Frosch MP, Kayed R, Del Monte F. Aß Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart. J Am Coll Cardiol. 2016 Dec 06; 68(22):2395-2407. PMID: 27908343.
    View in: PubMed
  8. Strickland MR, Gill CM, Nayyar N, D'Andrea MR, Thiede C, Juratli TA, Schackert G, Borger DR, Santagata S, Frosch MP, Cahill DP, Brastianos PK, Barker FG. Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas. J Neurosurg. 2016 Nov 25; 1-7. PMID: 27885953.
    View in: PubMed
  9. Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A, Suvà ML. Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313. PMID: 27806376.
    View in: PubMed
  10. Friedman GN, Grannan BL, Yanamadala V, Shankar GM, Dewitt JC, Puthenpura V, Koffie RM, Macdonald SM, Ebb DH, Frosch MP, Duhaime AC. Rapid Neurological Recovery Following Partial Surgical Resection of Spinal Glioblastoma Multiforme in a Pediatric Patient Presenting With Complete Paraplegia. J Pediatr Hematol Oncol. 2016 Nov; 38(8):e286-e290. PMID: 27403775.
    View in: PubMed
  11. van Veluw SJ, Kuijf HJ, Charidimou A, Viswanathan A, Biessels GJ, Rozemuller AJ, Frosch MP, Greenberg SM. Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy. Acta Neuropathol. 2017 Mar; 133(3):409-415. PMID: 27771772.
    View in: PubMed
  12. Hopfner F, Haubenberger D, Galpern WR, Gwinn K, Van't Veer A, White S, Bhatia K, Adler CH, Eidelberg D, Ondo W, Stebbins GT, Tanner CM, Helmich RC, Lenz FA, Sillitoe RV, Vaillancourt D, Vitek JL, Louis ED, Shill HA, Frosch MP, Foroud T, Kuhlenbäumer G, Singleton A, Testa CM, Hallett M, Elble R, Deuschl G. Knowledge gaps and research recommendations for essential tremor. Parkinsonism Relat Disord. 2016 Dec; 33:27-35. PMID: 27769649.
    View in: PubMed
  13. van Veluw SJ, Charidimou A, van der Kouwe AJ, Lauer A, Reijmer YD, Costantino I, Gurol ME, Biessels GJ, Frosch MP, Viswanathan A, Greenberg SM. Microbleed and microinfarct detection in amyloid angiopathy: a high-resolution MRI-histopathology study. Brain. 2016 Dec; 139(Pt 12):3151-3162. PMID: 27645801.
    View in: PubMed
  14. Liu J, Costantino I, Venugopalan N, Fischetti RF, Hyman BT, Frosch MP, Gomez-Isla T, Makowski L. Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue. Sci Rep. 2016 Sep 15; 6:33079. PMID: 27629394.
    View in: PubMed
  15. Lauer A, van Veluw SJ, William CM, Charidimou A, Roongpiboonsopit D, Vashkevich A, Ayres A, Martinez-Ramirez S, Gurol EM, Biessels GJ, Frosch M, Greenberg SM, Viswanathan A. Microbleeds on MRI are associated with microinfarcts on autopsy in cerebral amyloid angiopathy. Neurology. 2016 Oct 04; 87(14):1488-1492. PMID: 27613583.
    View in: PubMed
  16. Chang J, Arani K, Chew S, Frosch MP, Gonzalez RG, Maza N, Romero JM. Susceptibility Etching on MRI in Patients with Microangiopathy. J Neuroimaging. 2017 Jan; 27(1):43-49. PMID: 27539492.
    View in: PubMed
  17. Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 Sep; 80(3):355-67. PMID: 27351289; PMCID: PMC5016222 [Available on 09/01/17].
  18. Charidimou A, Martinez-Ramirez S, Reijmer YD, Oliveira-Filho J, Lauer A, Roongpiboonsopit D, Frosch M, Vashkevich A, Ayres A, Rosand J, Gurol ME, Greenberg SM, Viswanathan A. Total Magnetic Resonance Imaging Burden of Small Vessel Disease in Cerebral Amyloid Angiopathy: An Imaging-Pathologic Study of Concept Validation. JAMA Neurol. 2016 Aug 01; 73(8):994-1001. PMID: 27366898.
    View in: PubMed
  19. Vodopivec I, Cho TA, Rizzo JF, Frosch MP, Sims KB. Mitochondrial Encephalopathy and Optic Neuropathy Due to m.10158 MT-ND3 Complex I Mutation Presenting in an Adult Patient: Case Report and Review of the Literature. Neurologist. 2016 Jul; 21(4):61-5. PMID: 27348141.
    View in: PubMed
  20. Roberts DJ, Frosch MP. Zika and histopathology in first trimester infections. Lancet. 2016 Aug 27; 388(10047):847-9. PMID: 27372399.
    View in: PubMed
  21. Ronthal M, Venna N, Hunter GJ, Frosch MP. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 15-2016. A 32-Year-Old Man with Olfactory Hallucinations and Paresthesias. N Engl J Med. 2016 May 19; 374(20):1966-75. PMID: 27192675.
    View in: PubMed
  22. Singhal AB, Topcuoglu MA, Fok JW, Kursun O, Nogueira RG, Frosch MP, Caviness VS. Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: clinical, imaging, and angiographic comparison. Ann Neurol. 2016 Jun; 79(6):882-94. PMID: 27043703.
    View in: PubMed
  23. Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann AG, Spires-Jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M, Hyman BT, Schmid AW. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimers Dement. 2016 Sep; 12(9):996-1013. PMID: 27130892.
    View in: PubMed
  24. Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT. Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum. J Neuropathol Exp Neurol. 2016 Jun; 75(6):516-26. PMID: 27105663.
    View in: PubMed
  25. Walker MA, Mohler KP, Hopkins KW, Oakley DH, Sweetser DA, Ibba M, Frosch MP, Thibert RL. Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease. J Child Neurol. 2016 Aug; 31(9):1127-37. PMID: 27095821; PMCID: PMC4981184 [Available on 08/01/17].
  26. Auriel E, Charidimou A, Gurol ME, Ni J, Van Etten ES, Martinez-Ramirez S, Boulouis G, Piazza F, DiFrancesco JC, Frosch MP, Pontes-Neto OV, Shoamanesh A, Reijmer Y, Vashkevich A, Ayres AM, Schwab KM, Viswanathan A, Greenberg SM. Validation of Clinicoradiological Criteria for the Diagnosis of Cerebral Amyloid Angiopathy-Related Inflammation. JAMA Neurol. 2016 Feb; 73(2):197-202. PMID: 26720093.
    View in: PubMed
  27. Yanamadala V, Koffie RM, Shankar GM, Kumar JI, Buchlak QD, Puthenpura V, Frosch MP, Gudewicz TM, Borges LF, Shin JH. Spinal cord glioblastoma: 25years of experience from a single institution. J Clin Neurosci. 2016 May; 27:138-41. PMID: 26755453.
    View in: PubMed
  28. Serrano-Pozo A, Betensky RA, Frosch MP, Hyman BT. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. Am J Pathol. 2016 Feb; 186(2):375-84. PMID: 26687817; PMCID: PMC4729270 [Available on 02/01/17].
  29. Murray E, Cho JH, Goodwin D, Ku T, Swaney J, Kim SY, Choi H, Park YG, Park JY, Hubbert A, McCue M, Vassallo S, Bakh N, Frosch MP, Wedeen VJ, Seung HS, Chung K. Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems. Cell. 2015 Dec 03; 163(6):1500-14. PMID: 26638076.
    View in: PubMed
  30. Butovsky O, Jedrychowski MP, Cialic R, Murugaiyan G, Wu PM, Doykan CE, Fanek Z, Greco DJ, Kiner O, Lawson RJ, Frosch MP, Pochet N, Krichevsky AM, Gygi SP, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5. PMID: 26531345.
    View in: PubMed
  31. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. PMID: 26564777; PMCID: PMC4643219.
  32. Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490. PMID: 26458742; PMCID: PMC4608380.
  33. Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov; 78(5):787-800. PMID: 26344059; PMCID: PMC4900162 [Available on 11/01/16].
  34. Musolino PL, Gong Y, Snyder JM, Jimenez S, Lok J, Lo EH, Moser AB, Grabowski EF, Frosch MP, Eichler FS. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain. 2015 Nov; 138(Pt 11):3206-20. PMID: 26377633; PMCID: PMC4731416 [Available on 11/01/16].
  35. Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016 Feb; 12(2):164-9. PMID: 26327235; PMCID: PMC4562409 [Available on 02/01/17].
  36. Zhao L, Arbel-Ornath M, Wang X, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy. Neurobiol Aging. 2015 Nov; 36(11):2963-71. PMID: 26248866; PMCID: PMC4609585 [Available on 11/01/16].
  37. Auriel E, Westover MB, Bianchi MT, Reijmer Y, Martinez-Ramirez S, Ni J, Van Etten E, Frosch MP, Fotiadis P, Schwab K, Vashkevich A, Boulouis G, Younger AP, Johnson KA, Sperling RA, Hedden T, Gurol ME, Viswanathan A, Greenberg SM. Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging. Stroke. 2015 Aug; 46(8):2129-35. PMID: 26159796; PMCID: PMC4519384.
  38. Martinez-Ramirez S, Romero JR, Shoamanesh A, McKee AC, Van Etten E, Pontes-Neto O, Macklin EA, Ayres A, Auriel E, Himali JJ, Beiser AS, DeCarli C, Stein TD, Alvarez VE, Frosch MP, Rosand J, Greenberg SM, Gurol ME, Seshadri S, Viswanathan A. Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement. 2015 Dec; 11(12):1480-8. PMID: 26079413; PMCID: PMC4677060 [Available on 12/01/16].
  39. Iglesias JE, Augustinack JC, Nguyen K, Player CM, Player A, Wright M, Roy N, Frosch MP, McKee AC, Wald LL, Fischl B, Van Leemput K. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI. Neuroimage. 2015 Jul 15; 115:117-37. PMID: 25936807; PMCID: PMC4461537 [Available on 07/15/16].
  40. Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM, Frosch MP, Walsh DM. The aqueous phase of Alzheimer's disease brain contains assemblies built from ~4 and ~7 kDa Aß species. Alzheimers Dement. 2015 Nov; 11(11):1286-305. PMID: 25846299; PMCID: PMC4592782 [Available on 11/01/16].
  41. Miller BL, Dickerson BC, Lucente DE, Larvie M, Frosch MP. Case records of the Massachusetts General Hospital. Case 9-2015. A 31-year-old man with personality changes and progressive neurologic decline. N Engl J Med. 2015 Mar 19; 372(12):1151-62. PMID: 25785973; PMCID: PMC4795456.
  42. Etherton MR, Neagu MR, Oakley DH, Koch MJ, Shin JH, Frosch MP, Berkowitz AL, Dietrich J. A 20-year-old man with back pain and lower extremity weakness. JAMA Neurol. 2015 Mar; 72(3):363-6. PMID: 25621865.
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  43. Charidimou A, Martinez-Ramirez S, Shoamanesh A, Oliveira-Filho J, Frosch M, Vashkevich A, Ayres A, Rosand J, Gurol ME, Greenberg SM, Viswanathan A. Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes. Neurology. 2015 Mar 24; 84(12):1206-12. PMID: 25716356; PMCID: PMC4366086.
  44. Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžic S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B. Optical coherence tomography visualizes neurons in human entorhinal cortex. Neurophotonics. 2015 Feb 09; 2(1):015004. PMID: 25741528.
    View in: PubMed
  45. Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology. 2015 Mar 10; 84(10):972-80. PMID: 25663231; PMCID: PMC4352096.
  46. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. PMID: 25531812; PMCID: PMC4324097.
  47. Scripko P, Oaklander AL, Koeppen AH, Frosch MP, Schmahmann JD. A 40-year-old woman with difficulty going down stairs in high-heeled shoes. Ann Neurol. 2015 Jan; 77(1):1-7. PMID: 25380064.
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  48. Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco DJ, Wu PM, Doykan CE, Kiner O, Lawson RJ, Frosch MP, Pochet N, Fatimy RE, Krichevsky AM, Gygi SP, Lassmann H, Berry J, Cudkowicz ME, Weiner HL. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan; 77(1):75-99. PMID: 25381879; PMCID: PMC4432483.
  49. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. PMID: 25199842; PMCID: PMC4314944.
  50. Tai HC, Wang BY, Serrano-Pozo A, Frosch MP, Spires-Jones TL, Hyman BT. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathol Commun. 2014 Oct 21; 2:146. PMID: 25330988; PMCID: PMC4209049.
  51. Augustinack JC, van der Kouwe AJ, Salat DH, Benner T, Stevens AA, Annese J, Fischl B, Frosch MP, Corkin S. H.M.'s contributions to neuroscience: a review and autopsy studies. Hippocampus. 2014 Nov; 24(11):1267-86. PMID: 25154857.
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  103. Greenberg SM, Frosch MP. Life imitates art: anti-amyloid antibodies and inflammatory cerebral amyloid angiopathy. Neurology. 2011 Mar 01; 76(9):772-3. PMID: 21357829.
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  104. di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Res. 2011 Jan 01; 71(1):19-28. PMID: 21199795; PMCID: PMC3074948.
  105. Biffi A, Plourde A, Shen Y, Onofrio R, Smith EE, Frosch M, Prada CM, Gusella J, Greenberg SM, Rosand J. Screening for familial APP mutations in sporadic cerebral amyloid angiopathy. PLoS One. 2010 Nov 11; 5(11):e13949. PMID: 21085603; PMCID: PMC2978718.
  106. Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci. 2010 Nov; 13(11):1396-403. PMID: 20953194; PMCID: PMC2967729.
  107. Dierksen GA, Skehan ME, Khan MA, Jeng J, Nandigam RN, Becker JA, Kumar A, Neal KL, Betensky RA, Frosch MP, Rosand J, Johnson KA, Viswanathan A, Salat DH, Greenberg SM. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol. 2010 Oct; 68(4):545-8. PMID: 20865701; PMCID: PMC2964411.
  108. Smith EE, Nandigam KR, Chen YW, Jeng J, Salat D, Halpin A, Frosch M, Wendell L, Fazen L, Rosand J, Viswanathan A, Greenberg SM. MRI markers of small vessel disease in lobar and deep hemispheric intracerebral hemorrhage. Stroke. 2010 Sep; 41(9):1933-8. PMID: 20689084; PMCID: PMC4084787.
  109. Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J Neuropathol Exp Neurol. 2010 Aug; 69(8):777-88. PMID: 20613640; PMCID: PMC2918281.
  110. Greenberg SM, Rapalino O, Frosch MP. Case records of the Massachusetts General Hospital. Case 22-2010. An 87-year-old woman with dementia and a seizure. N Engl J Med. 2010 Jul 22; 363(4):373-81. PMID: 20660406.
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  111. Edlow BL, Wainger BJ, Frosch MP, Copen WA, Rathmell JP, Rost NS. Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury. Anesthesiology. 2010 Jun; 112(6):1532-5. PMID: 20460995.
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  112. Nelson PT, Kukull WA, Frosch MP. Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations. J Neuropathol Exp Neurol. 2010 May; 69(5):449-54. PMID: 20418781; PMCID: PMC2892786.
  113. Cahill DP, Barker FG, Davis KR, Kalva SP, Sahai I, Frosch MP. Case records of the Massachusetts General Hospital. Case 10-2010. A 37-year-old woman with weakness and a mass in the brain. N Engl J Med. 2010 Apr 08; 362(14):1326-33. PMID: 20375410.
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  114. Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain. 2010 May; 133(Pt 5):1312-27. PMID: 20360050; PMCID: PMC2859150.
  115. Pless ML, Chen YB, Copen WA, Frosch MP. Case records of the Massachusetts General Hospital. Case 9-2010. A 37-year-old woman with paresthesias and ataxia. N Engl J Med. 2010 Mar 25; 362(12):1129-38. PMID: 20335590.
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  116. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673; PMCID: PMC2828525.
  117. Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM. CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. Hum Mol Genet. 2010 May 01; 19(9):1756-65. PMID: 20147317; PMCID: PMC2850620.
  118. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann-Haerter K, Liu C, Wang Y, Frosch MP, Waeber C, Ayata C, Moskowitz MA. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol. 2010 Feb; 67(2):221-9. PMID: 20225282; PMCID: PMC2921919.
  119. Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW. Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution. J Alzheimers Dis. 2010; 22(1):235-45. PMID: 20847418; PMCID: PMC3813954.
  120. Rutgers KS, van Remoortere A, van Buchem MA, Verrips CT, Greenberg SM, Bacskai BJ, Frosch MP, van Duinen SG, Maat-Schieman ML, van der Maarel SM. Differential recognition of vascular and parenchymal beta amyloid deposition. Neurobiol Aging. 2011 Oct; 32(10):1774-83. PMID: 20015576; PMCID: PMC2891162.
  121. Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med. 2009 Dec; 133(12):1949-53. PMID: 19961250; PMCID: PMC3694269.
  122. Gerstner ER, Frosch MP, Batchelor TT. Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab. J Clin Oncol. 2010 Feb 20; 28(6):e91-3. PMID: 19933906.
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  123. Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 2009; 28(5):471-5. PMID: 19940479.
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  124. Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J Neurosci. 2009 Nov 18; 29(46):14646-51. PMID: 19923297; PMCID: PMC3849752.
  125. Chu-Shore CJ, Frosch MP, Grant PE, Thiele EA. Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings. Epilepsia. 2009 Dec; 50(12):2648-51. PMID: 19624715.
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  126. Greenberg SM, Nandigam RN, Delgado P, Betensky RA, Rosand J, Viswanathan A, Frosch MP, Smith EE. Microbleeds versus macrobleeds: evidence for distinct entities. Stroke. 2009 Jul; 40(7):2382-6. PMID: 19443797; PMCID: PMC2758289.
  127. Brass SD, Smith EE, Arboleda-Velasquez JF, Copen WA, Frosch MP. Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members. N Engl J Med. 2009 Apr 16; 360(16):1656-65. PMID: 19369672.
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  128. Fischl B, Stevens AA, Rajendran N, Yeo BT, Greve DN, Van Leemput K, Polimeni JR, Kakunoori S, Buckner RL, Pacheco J, Salat DH, Melcher J, Frosch MP, Hyman BT, Grant PE, Rosen BR, van der Kouwe AJ, Wiggins GC, Wald LL, Augustinack JC. Predicting the location of entorhinal cortex from MRI. Neuroimage. 2009 Aug 01; 47(1):8-17. PMID: 19376238; PMCID: PMC2738987.
  129. Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J Neurochem. 2009 Jun; 109(6):1636-47. PMID: 19457117; PMCID: PMC3281746.
  130. Major P, Rakowski S, Simon MV, Cheng ML, Eskandar E, Baron J, Leeman BA, Frosch MP, Thiele EA. Are cortical tubers epileptogenic? Evidence from electrocorticography. Epilepsia. 2009 Jan; 50(1):147-54. PMID: 19125835.
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  131. Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J Neuropathol Exp Neurol. 2008 Dec; 67(12):1205-12. PMID: 19018241; PMCID: PMC2734185.
  132. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075; PMCID: PMC2612087.
  133. Greenberg SM, Grabowski T, Gurol ME, Skehan ME, Nandigam RN, Becker JA, Garcia-Alloza M, Prada C, Frosch MP, Rosand J, Viswanathan A, Smith EE, Johnson KA. Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B. Ann Neurol. 2008 Nov; 64(5):587-91. PMID: 19067370; PMCID: PMC2605158.
  134. Nakagawa K, Sheikh SI, Snuderl M, Frosch MP, Greenberg SM. A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis. J Neurol Sci. 2008 Sep 15; 272(1-2):186-90. PMID: 18579156.
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  135. Eichler FS, Ren JQ, Cossoy M, Rietsch AM, Nagpal S, Moser AB, Frosch MP, Ransohoff RM. Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy? Ann Neurol. 2008 Jun; 63(6):729-42. PMID: 18571777.
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  136. di Tomaso E, Frosch MP, Auluck PK, Cahill D, Duda DG, Plotkin SR, Loeffler JS, Sorensen AG, Batchelor TT, Jain RK. Characterization of blood vessels in brain autopsies of GBM patients who received antiangiogenic treatment. J Clin Oncol. 2008 May 20; 26(15_suppl):2009. PMID: 27948447.
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  137. Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD. Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations. Brain Pathol. 2009 Jan; 19(1):39-47. PMID: 18422757; PMCID: PMC2757058.
  138. Freeman SH, Spires-Jones T, Hyman BT, Growdon JH, Frosch MP. TAR-DNA binding protein 43 in Pick disease. J Neuropathol Exp Neurol. 2008 Jan; 67(1):62-7. PMID: 18091558.
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  139. Sabatine MS, Poh KK, Mega JL, Shepard JA, Stone JR, Frosch MP. Case records of the Massachusetts General Hospital. Case 36-2007. A 31-year-old woman with rash, fever, and hypotension. N Engl J Med. 2007 Nov 22; 357(21):2167-78. PMID: 18032767.
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  140. Ingelsson M, Ramasamy K, Russ C, Freeman SH, Orne J, Raju S, Matsui T, Growdon JH, Frosch MP, Ghetti B, Brown RH, Irizarry MC, Hyman BT. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathol. 2007 Nov; 114(5):471-9. PMID: 17721707.
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  141. Cole AJ, Henson JW, Roehrl MH, Frosch MP. Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental status. N Engl J Med. 2007 Aug 09; 357(6):589-600. PMID: 17687135.
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  142. Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep; 130(Pt 9):2310-9. PMID: 17638859.
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  143. Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Res. 2007 Aug 03; 1161:116-23. PMID: 17586478.
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  144. Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM. Course of cerebral amyloid angiopathy-related inflammation. Neurology. 2007 Apr 24; 68(17):1411-6. PMID: 17452586.
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  145. Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC. Plasma Abeta levels do not reflect brain Abeta levels. J Neuropathol Exp Neurol. 2007 Apr; 66(4):264-71. PMID: 17413317.
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  146. Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, Frosch MP, Standaert DG. Effects of gender on nigral gene expression and parkinson disease. Neurobiol Dis. 2007 Jun; 26(3):606-14. PMID: 17412603; PMCID: PMC2435483.
  147. Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar; 64(3):431-4. PMID: 17353389.
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  148. Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci. 2007 Feb 21; 27(8):1973-80. PMID: 17314293.
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  149. Caviness VS, Sagar P, Israel EJ, Mackool BT, Grabowski EF, Frosch MP. Case records of the Massachusetts General Hospital. Case 38-2006. A 5-year-old boy with headache and abdominal pain. N Engl J Med. 2006 12 14; 355(24):2575-84. PMID: 17167141.
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  150. Ehlert K, Roth J, Frosch M, Fehse N, Zander N, Vormoor J. Farber's disease without central nervous system involvement: bone-marrow transplantation provides a promising new approach. Ann Rheum Dis. 2006 Dec; 65(12):1665-6. PMID: 17105855; PMCID: PMC1798467.
  151. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006 Dec; 24(3):516-24. PMID: 17029828.
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  152. Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21; 1111(1):222-6. PMID: 16919608.
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  153. Duffy KR, Murphy KM, Frosch MP, Livingstone MS. Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex. Cereb Cortex. 2007 Jun; 17(6):1283-91. PMID: 16831856; PMCID: PMC2628812.
  154. Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathol. 2006 Oct; 112(4):439-49. PMID: 16802167.
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  155. Costello DJ, Simon MV, Eskandar EN, Frosch MP, Henninger HL, Chiappa KH, Cole AJ. Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus. Arch Neurol. 2006 Jun; 63(6):895-901. PMID: 16769873.
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  156. Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. J Neuropathol Exp Neurol. 2006 May; 65(5):508-15. PMID: 16772874.
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  157. Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT. Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathol. 2006 Feb; 111(2):101-8. PMID: 16482476.
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  158. Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006 Jan 11; 26(2):365-71. PMID: 16407531.
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  159. Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol. 2006 Jan; 16(1):30-9. PMID: 16612980.
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  160. Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG. Alpha-synuclein and chaperones in dementia with Lewy bodies. J Neuropathol Exp Neurol. 2005 Dec; 64(12):1058-66. PMID: 16319716.
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  161. McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet. 2005 Nov 15; 14(22):3507-21. PMID: 16210380.
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  162. Johnson RT, Gonzalez RG, Frosch MP. Case records of the Massachusetts General Hospital. Case 27-2005. An 80-year-old man with fatigue, unsteady gait, and confusion. N Engl J Med. 2005 Sep 08; 353(10):1042-50. PMID: 16148290.
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  163. Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol. 2005 Jul; 64(7):588-94. PMID: 16042310.
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  164. Augustinack JC, van der Kouwe AJ, Blackwell ML, Salat DH, Wiggins CJ, Frosch MP, Wiggins GC, Potthast A, Wald LL, Fischl BR. Detection of entorhinal layer II using 7Tesla [corrected] magnetic resonance imaging. Ann Neurol. 2005 Apr; 57(4):489-94. PMID: 15786476; PMCID: PMC3857582.
  165. Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17. PMID: 15772361.
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  166. Casey PJ, Black JH, Szabo C, Frosch M, Albadawi H, Chen M, Cambria RP, Watkins MT. Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion. J Vasc Surg. 2005 Jan; 41(1):99-107. PMID: 15696051.
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  167. Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004 Oct 14; 44(2):227-38. PMID: 15473963.
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  168. Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6. PMID: 15448688.
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  169. Schlossmacher MG, Hamann C, Cole AG, Gonzalez RG, Frosch MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-2004. A 79-year-old woman with disturbances in gait, cognition, and autonomic function. N Engl J Med. 2004 Aug 26; 351(9):912-22. PMID: 15329430.
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  170. Koralnik IJ, Schellingerhout D, Frosch MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-2004. A 66-year-old man with progressive neurologic deficits. N Engl J Med. 2004 Apr 29; 350(18):1882-93. PMID: 15115835.
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  171. Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 2004 Mar 23; 62(6):925-31. PMID: 15037694.
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  172. Eng JA, Frosch MP, Choi K, Rebeck GW, Greenberg SM. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol. 2004 Feb; 55(2):250-6. PMID: 14755729.
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  173. Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH, Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiol Genomics. 2004 Jan 15; 16(2):229-39. PMID: 14645737.
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  174. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18; 40(6):1087-93. PMID: 14687544.
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  175. Ronthal M, Gonzalez RG, Smith RN, Frosch MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 21-2003. A 72-year-old man with repetitive strokes in the posterior circulation. N Engl J Med. 2003 Jul 10; 349(2):170-80. PMID: 12853591.
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  176. Kurzai O, Keith P, de Hoog S, Abele-Horn M, Frosch M. Postmortem isolation of Pseudotaeniolina globosa from a patient with aortic aneurysm. Mycoses. 2003 Apr; 46(3-4):141-4. PMID: 12870204.
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  177. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4162-7. PMID: 12634421; PMCID: PMC153065.
  178. Wulffraat NM, Haas PJ, Frosch M, De Kleer IM, Vogl T, Brinkman DM, Quartier P, Roth J, Kuis W. Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation. Ann Rheum Dis. 2003 Mar; 62(3):236-41. PMID: 12594109; PMCID: PMC1754451.
  179. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95. PMID: 12597857.
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  180. Achim C, Auer R, Bergeron C, Cardozo A, Deprez M, de Vos R, Duyckaerts C, Egensperger R, Esiri M, Frosch MP, Giannini C, Goebel HH, Graeber MB, Graham DI, Gray F, Haltia M, Hashizume Y, Ikeda K, Ironside JW, Kreutzberg GW, Lantos P, Lowe J, Ludwin S, Matsumoto Y, Olsson Y, Sasaki A, Scheithauer BW, Takahashi H, Tolnay M, Trojanowski JQ, Troost D, de F Webster H. Global democratic consensus on neuropathological disease criteria. Lancet Neurol. 2002 Oct; 1(6):340. PMID: 12849392.
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  181. Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep; 61(9):797-805. PMID: 12230326.
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  182. Arboleda-Velasquez JF, Lopera F, Lopez E, Frosch MP, Sepulveda-Falla D, Gutierrez JE, Vargas S, Medina M, Martinez De Arrieta C, Lebo RV, Slaugenhaupt SA, Betensky RA, Villegas A, Arcos-Burgos M, Rivera D, Restrepo JC, Kosik KS. C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke. Neurology. 2002 Jul 23; 59(2):277-9. PMID: 12136071.
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  183. Thaler DE, Frosch MP. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2002. A 41-year-old woman with global headache and an intracranial mass. N Engl J Med. 2002 May 23; 346(21):1651-8. PMID: 12023999.
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  184. Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002 May; 160(5):1655-67. PMID: 12000718; PMCID: PMC1850875.
  185. Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):295-8. PMID: 11814781.
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  186. Sudoh S, Frosch MP, Wolf BA. Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells. Biochemistry. 2002 Jan 29; 41(4):1091-9. PMID: 11802707.
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  187. Theobald I, Fischbach R, Hülskamp G, Franzius C, Frosch M, Roth J, Heindel W. [Pulmonary aspergillosis as initial manifestation of septic granulomatosis (chronic granulomatous disease, CGD) in a premature monozygotic female twin and FDG-PET diagnosis of spread of the disease]. Radiologe. 2002 Jan; 42(1):42-5. PMID: 11930540.
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  188. Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, MacDonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopoulos G, Gullans SR. A compendium of gene expression in normal human tissues. Physiol Genomics. 2001 Dec 21; 7(2):97-104. PMID: 11773596.
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  189. Scinto LF, Frosch M, Wu CK, Daffner KR, Gedi N, Geula C. Selective cell loss in Edinger-Westphal in asymptomatic elders and Alzheimer's patients. Neurobiol Aging. 2001 Sep-Oct; 22(5):729-36. PMID: 11705632.
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  190. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science. 2001 Jul 13; 293(5528):263-9. PMID: 11431533.
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  191. Kooistra O, Lüneberg E, Lindner B, Knirel YA, Frosch M, Zähringer U. Complex O-acetylation in Legionella pneumophila serogroup 1 lipopolysaccharide. Evidence for two genes involved in 8-O-acetylation of legionaminic acid. Biochemistry. 2001 Jun 26; 40(25):7630-40. PMID: 11412117.
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  192. Maiden MC, Frosch M. Molecular techniques for the investigation of meningococcal disease epidemiology. Mol Biotechnol. 2001 Jun; 18(2):119-34. PMID: 11471454.
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  193. Weig M, Frosch M, Tintelnot K, Haas A, Gross U, Linsmeier B, Heesemann J. Use of recombinant mitogillin for improved serodiagnosis of Aspergillus fumigatus-associated diseases. J Clin Microbiol. 2001 May; 39(5):1721-30. PMID: 11325981; PMCID: PMC88016.
  194. Franzius C, Biermann M, Hülskamp G, Frosch M, Roth J, Sciuk J, Schober O. Therapy monitoring in aspergillosis using F-18 FDG positron emission tomography. Clin Nucl Med. 2001 Mar; 26(3):232-3. PMID: 11245117.
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  195. Feany MB, Anthony DC, Frosch MP, Zane W, De Girolami U. August 2000: Two cases with necrosis and hemorrhage in the putamen and white matter. Brain Pathol. 2001 Jan; 11(1):121-2, 125. PMID: 11145199.
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  196. Brehm K, Jensen K, Frosch M. mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis. J Biol Chem. 2000 Dec 08; 275(49):38311-8. PMID: 10973970.
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  197. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem. 2000 Sep 08; 275(36):27901-8. PMID: 10846187.
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  198. Du Yan S, Zhu Y, Stern ED, Hwang YC, Hori O, Ogawa S, Frosch MP, Connolly ES, McTaggert R, Pinsky DJ, Clarke S, Stern DM, Ramasamy R. Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress. J Biol Chem. 2000 Sep 01; 275(35):27100-9. PMID: 10869339.
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  199. Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 2000 Sep; 27(3):561-72. PMID: 11055438.
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  200. Chan AW, Tarbell NJ, Black PM, Louis DN, Frosch MP, Ancukiewicz M, Chapman P, Loeffler JS. Adult medulloblastoma: prognostic factors and patterns of relapse. Neurosurgery. 2000 Sep; 47(3):623-31; discussion 631-2. PMID: 10981749.
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  201. Hilse R, Stoevesandt J, Caugant DA, Claus H, Frosch M, Vogel U. Distribution of the meningococcal insertion sequence IS1301 in clonal lineages of Neisseria meningitidis. Epidemiol Infect. 2000 Apr; 124(2):337-40. PMID: 10813160; PMCID: PMC2810918.
  202. Frosch M, Strey A, Vogl T, Wulffraat NM, Kuis W, Sunderkötter C, Harms E, Sorg C, Roth J. Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 2000 Mar; 43(3):628-37. PMID: 10728757.
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  203. Vogel U, Claus H, Frosch M. Rapid serogroup switching in Neisseria meningitidis. N Engl J Med. 2000 Jan 20; 342(3):219-20. PMID: 10651563.
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  204. Youssef P, Roth J, Frosch M, Costello P, Fitzgerald O, Sorg C, Bresnihan B. Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8/14 heterodimer in rheumatoid arthritis synovial membrane. J Rheumatol. 1999 Dec; 26(12):2523-8. PMID: 10606357.
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  205. Dixon GL, Heyderman RS, Kotovicz K, Jack DL, Andersen SR, Vogel U, Frosch M, Klein N. Endothelial adhesion molecule expression and its inhibition by recombinant bactericidal/permeability-increasing protein are influenced by the capsulation and lipooligosaccharide structure of Neisseria meningitidis. Infect Immun. 1999 Nov; 67(11):5626-33. PMID: 10531209; PMCID: PMC96935.
  206. Romig T, Kratzer W, Kimmig P, Frosch M, Gaus W, Flegel WA, Gottstein B, Lucius R, Beckh K, Kern P. An epidemiologic survey of human alveolar echinococcosis in southwestern Germany. Römerstein Study Group. Am J Trop Med Hyg. 1999 Oct; 61(4):566-73. PMID: 10548290.
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  207. Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis. Mol Immunol. 1999 Sep-Oct; 36(13-14):915-28. PMID: 10698346.
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  208. Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80. PMID: 10366748.
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  209. Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci. 1999 Jun 01; 19(11):4229-37. PMID: 10341227.
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  210. Albarracin CT, Frosch MP, Chin WW. The gonadotropin-releasing hormone receptor gene promoter directs pituitary-specific oncogene expression in transgenic mice. Endocrinology. 1999 May; 140(5):2415-21. PMID: 10218996.
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  211. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, Mayadas TN. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9. PMID: 9880401.
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  212. Hubert K, Cordero E, Frosch M, Solomon F. Activities of the EM10 protein from Echinococcus multilocularis in cultured mammalian cells demonstrate functional relationships to ERM family members. Cell Motil Cytoskeleton. 1999; 42(3):178-88. PMID: 10098932.
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  213. Paul R, Lorenzl S, Koedel U, Sporer B, Vogel U, Frosch M, Pfister HW. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol. 1998 Oct; 44(4):592-600. PMID: 9778257.
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  214. Simon DK, Rodriguez ML, Frosch MP, Quackenbush EJ, Feske SK, Natowicz MR. A unique familial leukodystrophy with adult onset dementia and abnormal glycolipid storage: a new lysosomal disease? J Neurol Neurosurg Psychiatry. 1998 Aug; 65(2):251-4. PMID: 9703182; PMCID: PMC2170209.
  215. Karvar S, Karch H, Frosch M, Burghardt W, Gross U. Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis. J Clin Microbiol. 1997 Dec; 35(12):3058-61. PMID: 9399494; PMCID: PMC230122.
  216. Lüneberg E, Müller D, Steinmetz I, Frosch M. Monoclonal antibody against species-specific epitope of Pseudomonas aeruginosa Hsp60 protein cross-reacts with Pseudomonas stutzeri and other Pseudomonas species. FEMS Microbiol Lett. 1997 Sep 01; 154(1):131-7. PMID: 9297831.
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  217. Fischman AJ, Thornton AF, Frosch MP, Swearinger B, Gonzalez RG, Alpert NM. FDG hypermetabolism associated with inflammatory necrotic changes following radiation of meningioma. J Nucl Med. 1997 Jul; 38(7):1027-9. PMID: 9225785.
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  218. Stemmer-Rachamimov AO, Horgan MA, Taratuto AL, Munoz DG, Smith TW, Frosch MP, Louis DN. Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene. J Neuropathol Exp Neurol. 1997 May; 56(5):485-9. PMID: 9143261.
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  219. Carroll RS, Zhang J, Chauncey BW, Chantziara K, Frosch MP, Black PM. Apoptosis in astrocytic neoplasms. Acta Neurochir (Wien). 1997; 139(9):845-50. PMID: 9351989.
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  220. Mühlenhoff M, Eckhardt M, Bethe A, Frosch M, Gerardy-Schahn R. Autocatalytic polysialylation of polysialyltransferase-1. EMBO J. 1996 Dec 16; 15(24):6943-50. PMID: 9003770; PMCID: PMC452520.
  221. Vogel U, Steinmetz I, Frosch M. Avoiding artifacts in the infant rat model for bacterial meningitis: use of Sangur test strips for the rapid quantification of blood contamination in cerebrospinal fluid. Med Microbiol Immunol. 1996 May; 185(1):27-30. PMID: 8803950.
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  222. Mühlschlegel F, Frosch P, Castro A, Apfel H, Müller A, Frosch M. Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein. Mol Biochem Parasitol. 1995 Nov; 74(2):245-50. PMID: 8719168.
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  223. Zhu J, Frosch MP, Busque L, Beggs AH, Dashner K, Gilliland DG, Black PM. Analysis of meningiomas by methylation- and transcription-based clonality assays. Cancer Res. 1995 Sep 01; 55(17):3865-72. PMID: 7641206.
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  224. Evans SV, Sigurskjold BW, Jennings HJ, Brisson JR, To R, Tse WC, Altman E, Frosch M, Weisgerber C, Kratzin HD, et al. Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2-->8)-polysialic acid. Biochemistry. 1995 May 23; 34(20):6737-44. PMID: 7538787.
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  225. Eckhardt M, Mühlenhoff M, Bethe A, Koopman J, Frosch M, Gerardy-Schahn R. Molecular characterization of eukaryotic polysialyltransferase-1. Nature. 1995 Feb 23; 373(6516):715-8. PMID: 7854457.
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  226. Edwards U, Müller A, Hammerschmidt S, Gerardy-Schahn R, Frosch M. Molecular analysis of the biosynthesis pathway of the alpha-2,8 polysialic acid capsule by Neisseria meningitidis serogroup B. Mol Microbiol. 1994 Oct; 14(1):141-9. PMID: 7830552.
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  227. Frosch P, Hartmann M, Mühlschlegel F, Frosch M. Sequence heterogeneity of the echinococcal antigen B. Mol Biochem Parasitol. 1994 Mar; 64(1):171-5. PMID: 8078520.
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  228. Logigian EL, Shefner JM, Frosch MP, Kloman AS, Raynor EM, Adelman LS, Hollander D. Nonvasculitic, steroid-responsive mononeuritis multiplex. Neurology. 1993 May; 43(5):879-83. PMID: 8492941.
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  229. Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ. Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Am J Pathol. 1993 Jan; 142(1):17-24. PMID: 8424453; PMCID: PMC1886844.
  230. Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ. Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex. Neurobiol Aging. 1992 Sep-Oct; 13(5):561-7. PMID: 1281288.
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  231. Frosch MP, Lipton SA, Dichter MA. Desensitization of GABA-activated currents and channels in cultured cortical neurons. J Neurosci. 1992 Aug; 12(8):3042-53. PMID: 1379634.
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  232. Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol. 1992 Jul; 141(1):249-59. PMID: 1632466; PMCID: PMC1886563.
  233. Frosch MP, Dichter MA. Non-uniform distribution of GABA activated chloride channels in cultured cortical neurons. Neurosci Lett. 1992 Apr 13; 138(1):59-62. PMID: 1383879.
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  234. Frosch M, Müller D, Bousset K, Müller A. Conserved outer membrane protein of Neisseria meningitidis involved in capsule expression. Infect Immun. 1992 Mar; 60(3):798-803. PMID: 1371768; PMCID: PMC257557.
  235. Sipos A, Klocke M, Frosch M. Cloning and sequencing of the genes coding for the 10- and 60-kDa heat shock proteins from Pseudomonas aeruginosa and mapping of a species-specific epitope. Infect Immun. 1991 Sep; 59(9):3219-26. PMID: 1715325; PMCID: PMC258156.
  236. Sasahara M, Fries JW, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthron DT, Ross R, Collins T. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell. 1991 Jan 11; 64(1):217-27. PMID: 1986868.
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  237. Weisgerber C, Husmann M, Frosch M, Rheinheimer C, Peuckert W, Görgen I, Bitter-Suermann D. Embryonic neural cell adhesion molecule in cerebrospinal fluid of younger children: age-dependent decrease during the first year. J Neurochem. 1990 Dec; 55(6):2063-71. PMID: 2230809.
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  238. Husmann M, Roth J, Kabat EA, Weisgerber C, Frosch M, Bitter-Suermann D. Immunohistochemical localization of polysialic acid in tissue sections: differential binding to polynucleotides and DNA of a murine IgG and a human IgM monoclonal antibody. J Histochem Cytochem. 1990 Feb; 38(2):209-15. PMID: 1688896.
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  239. Tauck DL, Frosch MP, Lipton SA. Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture. Neuroscience. 1988 Oct; 27(1):193-203. PMID: 3200439.
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  240. Madison RD, Macklis JD, Frosch MP. Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption. Brain Res. 1988 Mar 29; 445(1):101-10. PMID: 3365549.
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  241. Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E. Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science. 1988 Mar 11; 239(4845):1293-6. PMID: 3344435.
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  242. Aizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. J Physiol. 1988 Feb; 396:75-91. PMID: 2842491; PMCID: PMC1192034.
  243. Frosch MP. GABA activated currents and channels in cultured rat cortical neurons. 1987.
  244. Saukkonen K, Haltia M, Frosch M, Bitter-Süerman D, Leinonen M. Antibodies to the capsular polysaccharide of Neisseria meningitidis group B or E. coli K1 bind to the brains of infant rats in vitro but not in vivo. Microb Pathog. 1986 Feb; 1(1):101-5. PMID: 3150023.
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  245. Verkman AS, Frosch MP. Temperature-jump studies of merocyanine 540 relaxation kinetics in lipid bilayer membranes. Biochemistry. 1985 Dec 03; 24(25):7117-22. PMID: 4084566.
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  246. Frosch MP, Dichter MA. Physiology and pharmacology of olfactory bulb neurons in dissociated cell culture. Brain Res. 1984 Jan 09; 290(2):321-32. PMID: 6692147.
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