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Stephanie Kristin Dougan, Ph.D.

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Mentoring
Available: 09/27/18, Expires: 09/30/21

We have identified a targeted agent that alters NF-kB signaling in both tumor cells and immune cells. In T cells, this drug greatly enhances costimulatory signaling, thereby augmenting T cell priming and effector functions. The student will examine tumor infiltrates from mouse models of breast and pancreatic cancer to help identify the cellular targets of altered NF-kB signaling. As an additional benefit, the student would be able to join the DFCI Ludwig Center and attend meetings on cancer biology, if so desired.

Available: 09/27/18, Expires: 12/31/20

This is a wet lab basic science project that covers aspects of CD8 T cell priming and commitment to the memory lineage. The student will culture primary human CD8 T cells, collect RNA and evaluate transcriptional data sets to identify memory precursors signatures.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Luoma AM, Suo S, Williams HL, Sharova T, Sullivan K, Manos M, Bowling P, Hodi FS, Rahma O, Sullivan RJ, Boland GM, Nowak JA, Dougan SK, Dougan M, Yuan GC, Wucherpfennig KW. Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020 Jun 25. PMID: 32603654.
    Citations:    
  2. Crowley SJ, Bruck PT, Bhuiyan MA, Mitchell-Gears A, Walsh MJ, Zhangxu K, Ali LR, Jeong HJ, Ingram JR, Knipe DM, Ploegh HL, Dougan M, Dougan SK. Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH. Open Biol. 2020 02; 10(2):190235. PMID: 32019478.
    Citations:    
  3. Dougan SK, Dougan M. SMAC mimetics throw a molecular switch to control TH17 responses. Sci Signal. 2019 08 27; 12(596). PMID: 31455724.
    Citations:    
  4. Dougan M, Dougan SK. Programmable bacteria as cancer therapy. Nat Med. 2019 07; 25(7):1030-1031. PMID: 31270505.
    Citations:    
  5. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 07 15; 38(14):e101260. PMID: 31304630.
    Citations:    
  6. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 May 31. PMID: 31152007.
    Citations:    
  7. Dougan M, Dranoff G, Dougan SK. GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity. 2019 04 16; 50(4):796-811. PMID: 30995500.
    Citations:    
  8. Balachandran VP, Beatty GL, Dougan SK. Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. Gastroenterology. 2019 05; 156(7):2056-2072. PMID: 30660727.
    Citations:    Fields:    
  9. Clancy-Thompson E, Devlin CA, Tyler PM, Servos MM, Ali LR, Ventre KS, Bhuiyan MA, Bruck PT, Birnbaum ME, Dougan SK. Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses. Cancer Immunol Res. 2018 12; 6(12):1524-1536. PMID: 30352798.
    Citations:    
  10. Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer. Front Immunol. 2018; 9:2030. PMID: 30245691.
    Citations:    
  11. Ito Y, Ashenberg O, Pyrdol J, Luoma AM, Rozenblatt-Rosen O, Hofree M, Christian E, Ferrari de Andrade L, Tay RE, Teyton L, Regev A, Dougan SK, Wucherpfennig KW. Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. J Exp Med. 2018 10 01; 215(10):2617-2635. PMID: 30185635.
    Citations:    Fields:    
  12. Lin YC, Pecetta S, Steichen JM, Kratochvil S, Melzi E, Arnold J, Dougan SK, Wu L, Kirsch KH, Nair U, Schief WR, Batista FD. One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice. EMBO J. 2018 09 14; 37(18). PMID: 30087111.
    Citations:    Fields:    
  13. Heckler M, Dougan SK. Unmasking Pancreatic Cancer: Epitope Spreading After Single Antigen Chimeric Antigen Receptor T-Cell Therapy in a Human Phase I Trial. Gastroenterology. 2018 07; 155(1):11-14. PMID: 29885301.
    Citations:    Fields:    Translation:Humans
  14. Dougan SK, Dougan M. Regulation of innate and adaptive antitumor immunity by IAP antagonists. Immunotherapy. 2018 07; 10(9):787-796. PMID: 29807457.
    Citations: 1     Fields:    
  15. Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci Transl Med. 2018 04 11; 10(436). PMID: 29643230.
    Citations: 2     Fields:    
  16. Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M. Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3912-3917. PMID: 29581255.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs. Cancer Immunol Res. 2018 04; 6(4):389-401. PMID: 29459478.
    Citations: 2     Fields:    
  18. Jeong HJ, Abhiraman GC, Story CM, Ingram JR, Dougan SK. Generation of Ca2+-independent sortase A mutants with enhanced activity for protein and cell surface labeling. PLoS One. 2017; 12(12):e0189068. PMID: 29200433.
    Citations: 1     Fields:    Translation:Cells
  19. Clancy-Thompson E, Ali L, Bruck PT, Exley MA, Blumberg RS, Dranoff G, Dougan M, Dougan SK. IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells. Cancer Immunol Res. 2018 01; 6(1):25-35. PMID: 29187357.
    Citations: 1     Fields:    
  20. Dougan SK. The Pancreatic Cancer Microenvironment. Cancer J. 2017 Nov/Dec; 23(6):321-325. PMID: 29189327.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL. PD-L1 is an activation-independent marker of brown adipocytes. Nat Commun. 2017 09 21; 8(1):647. PMID: 28935898.
    Citations: 7     Fields:    Translation:AnimalsCells
  22. Zeissig S, Peuker K, Iyer S, Gensollen T, Dougan SK, Olszak T, Kaser A, Blumberg RS. CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10449-10454. PMID: 28893990.
    Citations: 3     Fields:    Translation:AnimalsCells
  23. Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10184-10189. PMID: 28874561.
    Citations: 3     Fields:    Translation:Animals
  24. Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. J Immunol. 2017 07 01; 199(1):159-171. PMID: 28576977.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Dougan M, Dougan SK. Targeting Immunotherapy to the Tumor Microenvironment. J Cell Biochem. 2017 10; 118(10):3049-3054. PMID: 28332219.
    Citations: 4     Fields:    Translation:HumansAnimals
  26. Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3157-3162. PMID: 28270614.
    Citations: 7     Fields:    
  27. Tyler PM, Servos MM, de Vries RC, Klebanov B, Kashyap T, Sacham S, Landesman Y, Dougan M, Dougan SK. Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy. Mol Cancer Ther. 2017 03; 16(3):428-439. PMID: 28148714.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T. Cocapture of cognate and bystander antigens can activate autoreactive B cells. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):734-739. PMID: 28057865.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL. Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor. Sci Immunol. 2016 Aug 26; 1(2):eaaf7471. PMID: 28783695.
    Citations: 5     Fields:    
  30. Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM. Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. Immunology. 2016 Nov; 149(3):270-279. PMID: 27377596.
    Citations: 1     Fields:    Translation:AnimalsCells
  31. Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3599-608. PMID: 27303033.
    Citations: 7     Fields:    Translation:HumansCells
  32. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 08 18; 536(7616):359. PMID: 26982724.
    Citations: 7     Fields:    
  33. Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2016 Feb; 34(2):210. PMID: 26849523.
    Citations: 1     Fields:    
  34. Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. PLoS Pathog. 2015 Oct; 11(10):e1005188. PMID: 26431038.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2015 May; 33(5):538-42. PMID: 25798939.
    Citations: 215     Fields:    Translation:AnimalsCells
  36. Dura B, Dougan SK, Barisa M, Hoehl MM, Lo CT, Ploegh HL, Voldman J. Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing. Nat Commun. 2015 Jan 13; 6:5940. PMID: 25585172.
    Citations: 15     Fields:    Translation:AnimalsCells
  37. Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U. A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Hum Vaccin Immunother. 2015; 11(8):2038-50. PMID: 26024409.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Strijbis K, Yilmaz OH, Dougan SK, Esteban A, Gröne A, Kumamoto CA, Ploegh HL. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. PLoS One. 2014; 9(11):e112472. PMID: 25379804.
    Citations:    Fields:    Translation:HumansAnimalsCells
  39. Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS. Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4. Gut. 2015 Dec; 64(12):1889-97. PMID: 25367873.
    Citations: 26     Fields:    Translation:HumansCells
  40. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. PMID: 25363763.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  41. Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF. Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10131-6. PMID: 24982154.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  42. Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7. PMID: 24476824.
    Citations: 46     Fields:    Translation:AnimalsCells
  43. Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 2013 Nov 21; 503(7476):406-9. PMID: 24141948.
    Citations: 25     Fields:    Translation:AnimalsCells
  44. Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity. Cancer Immunol Res. 2013 Aug; 1(2):99-111. PMID: 24459675.
    Citations: 10     Fields:    Translation:AnimalsCells
  45. Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A. Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol. 2013 Jul; 11(7):e1001618. PMID: 23935453.
    Citations: 18     Fields:    Translation:AnimalsCells
  46. Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL. Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. PLoS Pathog. 2013; 9(6):e1003446. PMID: 23825946.
    Citations: 24     Fields:    Translation:AnimalsCells
  47. Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL. IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13739-44. PMID: 22869725.
    Citations: 14     Fields:    Translation:AnimalsCells
  48. Witte MD, Cragnolini JJ, Dougan SK, Yoder NC, Popp MW, Ploegh HL. Preparation of unnatural N-to-N and C-to-C protein fusions. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):11993-8. PMID: 22778432.
    Citations: 37     Fields:    Translation:AnimalsCells
  49. Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, Guimaraes CP. M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins. Bioconjug Chem. 2012 Jul 18; 23(7):1478-87. PMID: 22759232.
    Citations: 20     Fields:    Translation:AnimalsCells
  50. Popp MW, Dougan SK, Chuang TY, Spooner E, Ploegh HL. Sortase-catalyzed transformations that improve the properties of cytokines. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3169-74. PMID: 21297034.
    Citations: 28     Fields:    Translation:AnimalsCells
  51. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar; 31(6):1145-59. PMID: 21220515.
    Citations: 10     Fields:    Translation:AnimalsCells
  52. Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27; 207(10):2195-206. PMID: 20837698.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  53. Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug; 120(8):2889-99. PMID: 20592474.
    Citations: 28     Fields:    Translation:HumansCells
  54. Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med. 2009 Oct 26; 206(11):2429-40. PMID: 19808260.
    Citations: 14     Fields:    Translation:AnimalsCells
  55. McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. J Immunol. 2009 Sep 15; 183(6):3690-9. PMID: 19710472.
    Citations: 22     Fields:    Translation:AnimalsCells
  56. Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 Jun 03; 28(11):1624-36. PMID: 19407814.
    Citations: 69     Fields:    Translation:AnimalsCells
  57. Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS. Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules. Eur J Immunol. 2008 Aug; 38(8):2351-9. PMID: 18624350.
    Citations: 17     Fields:    Translation:HumansCells
  58. Hussain MM, Rava P, Pan X, Dai K, Dougan SK, Iqbal J, Lazare F, Khatun I. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol. 2008 Jun; 19(3):277-84. PMID: 18460919.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  59. Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1101-5. PMID: 17717040.
    Citations: 13     Fields:    Translation:HumansAnimals
  60. Dougan SK, Rava P, Hussain MM, Blumberg RS. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007 Mar 19; 204(3):533-45. PMID: 17312007.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  61. Dougan SK, Kaser A, Blumberg RS. CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol. 2007; 314:113-41. PMID: 17593659.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  62. Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15; 202(4):529-39. PMID: 16087713.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  63. Chan WH, Zerizer I, Shergill N, Shergill I, Dougan S. A rare cause of abdominal pain. Gut. 2004 Sep; 53(9):1261, 1266. PMID: 15306581.
    Citations:    Fields:    Translation:Humans
  64. Dougan S, DiNardo S. Drosophila wingless generates cell type diversity among engrailed expressing cells. Nature. 1992 Nov 26; 360(6402):347-50. PMID: 1280330.
    Citations: 13     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.