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Hongbo Luo, Ph.D.

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Biography
Nankai University, ChinaB.S1992Molecular Biology
Brandeis University and HHMIPh.D.1999Molecular and Cell Biology
Johns Hopkins Medical School Post-Doc2004Molecular Pharmacology

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI145274 (LUO, HONGBO R) Sep 20, 2019 - Aug 31, 2024
    NIH/NIAID
    Regulation of neutrophil death by GSDMD in Candida albicans infection
    Role: Principal Investigator
  2. R01AI142642 (LUO, HONGBO R) Jun 12, 2019 - May 31, 2024
    NIH/NIAID
    Regulation of IL-1? bioactivity by Cysteine S-glutathionylation
    Role: Principal Investigator
  3. R01AI141386 (LUO, HONGBO R) Jan 2, 2019 - Dec 31, 2022
    NIH/NIAID
    Cell-based high-throughput chemical genetic screening for GSDMD inhibitors
    Role: Principal Investigator
  4. R01AI103142 (LUO, HONGBO R) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Regulation of neutrophil function by ROS-induced actin glutathionylation
    Role: Principal Investigator
  5. R01HL092020 (LUO, HONGBO R) Aug 1, 2009 - May 31, 2014
    NIH/NHLBI
    Enhancing neutrophil function in neutropenia-related pneumonia
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xie X, Shi Q, Wu P, Zhang X, Kambara H, Su J, Yu H, Park SY, Guo R, Ren Q, Zhang S, Xu Y, Silberstein LE, Cheng T, Ma F, Li C, Luo HR. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat Immunol. 2020 Jul 27. PMID: 32719519.
    Citations:    
  2. Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 Jul; 21(7):736-745. PMID: 32367036.
    Citations:    
  3. Zhang X, Karatepe K, Chiewchengchol D, Zhu H, Guo R, Liu P, Yu H, Ren Q, Luo X, Cheng T, Ma F, Xu Y, Han M, Luo HR. Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells. Front Immunol. 2020; 11:626. PMID: 32373117.
    Citations:    
  4. Wang Y, Sun X, Yuan S, Hou S, Guo T, Chu Y, Pang T, Luo HR, Yuan W, Wang X. Interleukin-1ß inhibits normal hematopoietic expansion and promotes acute myeloid leukemia progression via the bone marrow niche. Cytotherapy. 2020 03; 22(3):127-134. PMID: 32024607.
    Citations:    
  5. Kang SS, Liu X, Ahn EH, Xiang J, Manfredsson FP, Yang X, Luo HR, Liles LC, Weinshenker D, Ye K. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. J Clin Invest. 2020 01 02; 130(1):422-437. PMID: 31793911.
    Citations:    
  6. Zhang X, Guo R, Kambara H, Ma F, Luo HR. The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics. Curr Opin Hematol. 2019 01; 26(1):28-33. PMID: 30407218.
    Citations:    Fields:    
  7. You Y, Chen J, Zhu F, Xu Q, Han L, Gao X, Zhang X, Luo HR, Miao J, Sun X, Ren H, Du Y, Guo L, Wang X, Wang Y, Chen S, Huang N, Li J. Glutaredoxin 1 up-regulates deglutathionylation of a4 integrin and thereby restricts neutrophil mobilization from bone marrow. J Biol Chem. 2019 02 22; 294(8):2616-2627. PMID: 30598505.
    Citations:    Fields:    
  8. Karatepe K, Zhu H, Zhang X, Guo R, Kambara H, Loison F, Liu P, Yu H, Ren Q, Luo X, Manis J, Cheng T, Ma F, Xu Y, Luo HR. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018 11 13; 11(5):1092-1105. PMID: 30392974.
    Citations:    Fields:    
  9. Wang X, Gao Y, Gao J, Li M, Zhou M, Wang J, Pang Y, Cheng H, Yuan C, Chu Y, Jiang Y, Zhou J, Luo HR, Ju Z, Cheng T, Yuan W. Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo. Haematologica. 2019 02; 104(2):245-255. PMID: 30262562.
    Citations:    Fields:    
  10. Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JR. Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018 07; 14(7):e1007076. PMID: 30059535.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Kanneganti A, Malireddi RKS, Saavedra PHV, Vande Walle L, Van Gorp H, Kambara H, Tillman H, Vogel P, Luo HR, Xavier RJ, Chi H, Lamkanfi M. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018 06 04; 215(6):1519-1529. PMID: 29793924.
    Citations: 1     Fields:    
  12. Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 2018 05 01; 23(5):1387-1398. PMID: 29719252.
    Citations: 1     Fields:    
  13. Yan B, Xie S, Liu Y, Liu W, Li D, Liu M, Luo HR, Zhou J. Histone deacetylase 6 modulates macrophage infiltration during inflammation. Theranostics. 2018; 8(11):2927-2938. PMID: 29896294.
    Citations:    Fields:    
  14. Hou Q, Liu F, Chakraborty A, Jia Y, Prasad A, Yu H, Zhao L, Ye K, Snyder SH, Xu Y, Luo HR. Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med. 2018 04 04; 10(435). PMID: 29618559.
    Citations: 1     Fields:    
  15. Kambara H, Liu F, Zhang X, Liu P, Bajrami B, Teng Y, Zhao L, Zhou S, Yu H, Zhou W, Silberstein LE, Cheng T, Han M, Xu Y, Luo HR. Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Cell Rep. 2018 03 13; 22(11):2924-2936. PMID: 29539421.
    Citations: 3     Fields:    
  16. Zhang X, Liu P, Zhang C, Chiewchengchol D, Zhao F, Yu H, Li J, Kambara H, Luo KY, Venkataraman A, Zhou Z, Zhou W, Zhu H, Zhao L, Sakai J, Chen Y, Ho YS, Bajrami B, Xu B, Silberstein LE, Cheng T, Xu Y, Ke Y, Luo HR. Positive Regulation of Interleukin-1ß Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation. Cell Rep. 2017 07 05; 20(1):224-235. PMID: 28683316.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Teng Y, Luo HR, Kambara H. Heterogeneity of neutrophil spontaneous death. Am J Hematol. 2017 08; 92(8):E156-E159. PMID: 28437875.
    Citations:    Fields:    Translation:HumansCells
  18. Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017 04 01; 198(7):2854-2864. PMID: 28235862.
    Citations: 3     Fields:    Translation:AnimalsCells
  19. Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 09 19; 213(10):1999-2018. PMID: 27551153.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Li Z, Ye Z, Zhang X, Zhang Q, Fan D, Zhang Y, Luo HR, Yuan X, Li Z, Xiong D. E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice. Oncotarget. 2016 Aug 09; 7(32):51815-51828. PMID: 27322080.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Damnernsawad A, Kong G, Wen Z, Liu Y, Rajagopalan A, You X, Wang J, Zhou Y, Ranheim EA, Luo HR, Chang Q, Zhang J. Kras is Required for Adult Hematopoiesis. Stem Cells. 2016 07; 34(7):1859-71. PMID: 26972179.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Qi Q, Li DY, Luo HR, Guan KL, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7255-60. PMID: 26039999.
    Citations: 7     Fields:    Translation:HumansCells
  23. Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, Luo HR, Beck AH, Toker A. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Mol Oncol. 2015 Jun; 9(6):1140-54. PMID: 25735562.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  24. Luo HR, Mondal S. Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep. 2015 Feb; 16(2):149-63. PMID: 25576302.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71. PMID: 25579427.
    Citations: 17     Fields:    Translation:AnimalsCells
  26. Zhao F, Li J, Zhou N, Sakai J, Gao Y, Shi J, Goldman B, Browdy HM, Luo HR, Xu B. De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo. Bioconjug Chem. 2014 Dec 17; 25(12):2116-22. PMID: 25398017.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR. Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest. 2014 Oct; 124(10):4445-58. PMID: 25180606.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  28. Jo H, Loison F, Luo HR. Microtubule dynamics regulates Akt signaling via dynactin p150. Cell Signal. 2014 Aug; 26(8):1707-16. PMID: 24726838.
    Citations: 4     Fields:    Translation:HumansCells
  29. Luo HR. A dual regulator of neutrophil recruitment. Blood. 2014 Mar 27; 123(13):1983-5. PMID: 24677403.
    Citations:    Fields:    Translation:Animals
  30. Ma L, Gong H, Zhu H, Ji Q, Su P, Liu P, Cao S, Yao J, Jiang L, Han M, Ma X, Xiong D, Luo HR, Wang F, Zhou J, Xu Y. A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 2014 May 02; 289(18):12457-66. PMID: 24634219.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Loison F, Xu Y, Luo HR. Proteinase 3 and Serpin B1: a novel pathway in the regulation of caspase-3 activation, neutrophil spontaneous apoptosis, and inflammation. Inflamm Cell Signal. 2014; 1(6). PMID: 26029732.
    Citations: 2     
  32. Wang X, Robertson AL, Li J, Chai RJ, Haishan W, Sadiku P, Ogryzko NV, Everett M, Yoganathan K, Luo HR, Renshaw SA, Ingham PW. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis Model Mech. 2014 Jan; 7(1):163-9. PMID: 24291762.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  33. He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X, McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye K. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 09; 6(283):ra55. PMID: 23838182.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  34. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49. PMID: 23725762.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HR. Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7726-31. PMID: 23610437.
    Citations: 14     Fields:    Translation:AnimalsCells
  36. Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K. O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology. 2013; 91(3-4):185-200. PMID: 23445871.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Feb 21; 121(8):1413-21. PMID: 23287862.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  38. Sakai J, Li J, Subramanian KK, Mondal S, Bajrami B, Hattori H, Jia Y, Dickinson BC, Zhong J, Ye K, Chang CJ, Ho YS, Zhou J, Luo HR. Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012 Dec 14; 37(6):1037-49. PMID: 23159440.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  39. Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58. PMID: 23063331.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  40. Liu X, Chan CB, Qi Q, Xiao G, Luo HR, He X, Ye K. Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. J Med Chem. 2012 Oct 11; 55(19):8524-37. PMID: 22984948.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  41. Jo H, Mondal S, Tan D, Nagata E, Takizawa S, Sharma AK, Hou Q, Shanmugasundaram K, Prasad A, Tung JK, Tejeda AO, Man H, Rigby AC, Luo HR. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10581-6. PMID: 22689977.
    Citations: 52     Fields:    Translation:AnimalsCells
  42. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73. PMID: 22388960.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  43. Jo H, Luo HR. Exploiting effectors of Rac GTPase. Chem Biol. 2012 Feb 24; 19(2):169-71. PMID: 22365599.
    Citations: 1     Fields:    Translation:HumansCells
  44. Mondal S, Subramanian KK, Sakai J, Bajrami B, Luo HR. Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell. 2012 Apr; 23(7):1219-30. PMID: 22323291.
    Citations: 18     Fields:    Translation:AnimalsCells
  45. Takizawa S, Nagata E, Luo HR. [Novel neuroprotective agents: a HIF activator and an Akt activator]. Rinsho Shinkeigaku. 2012; 52(11):911-2. PMID: 23196464.
    Citations: 1     Fields:    Translation:HumansAnimals
  46. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3. PMID: 22155722.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol. 2011 Dec 01; 187(11):5783-94. PMID: 22043008.
    Citations: 7     Fields:    Translation:AnimalsCells
  48. He K, Chan CB, Liu X, Jia Y, Luo HR, France SA, Liu Y, Wilson WD, Ye K. Identification of a molecular activator for insulin receptor with potent anti-diabetic effects. J Biol Chem. 2011 Oct 28; 286(43):37379-88. PMID: 21908618.
    Citations: 4     Fields:    Translation:AnimalsCells
  49. Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol. 2011 Jun 19; 12(8):752-60. PMID: 21685907.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  50. Chan CB, Liu X, Pradoldej S, Hao C, An J, Yepes M, Luo HR, Ye K. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci. 2011 Jun 01; 31(22):8083-92. PMID: 21632930.
    Citations: 25     Fields:    Translation:AnimalsCells
  51. Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DA. Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9607-12. PMID: 21606370.
    Citations: 18     Fields:    Translation:AnimalsCells
  52. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13. PMID: 21521784.
    Citations: 23     Fields:    Translation:AnimalsCells
  53. Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6486-91. PMID: 21464312.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  54. Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem. 2010 Dec 09; 53(23):8274-86. PMID: 21073191.
    Citations: 45     Fields:    Translation:Animals
  55. Hattori H, Subramanian KK, Sakai J, Luo HR. Reactive oxygen species as signaling molecules in neutrophil chemotaxis. Commun Integr Biol. 2010 May; 3(3):278-81. PMID: 20714413.
    Citations: 4     
  56. Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR. Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010 Apr 23; 5(4):e10318. PMID: 20428237.
    Citations: 11     Fields:    Translation:HumansCells
  57. Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD. Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol. 2010 Aug; 88(2):313-9. PMID: 20413728.
    Citations: 10     Fields:    Translation:AnimalsCells
  58. Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 01; 184(9):5325-32. PMID: 20363972.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  59. Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51. PMID: 20142487.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  60. Xu Y, Loison F, Luo HR. Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):2950-5. PMID: 20133633.
    Citations: 20     Fields:    Translation:HumansCells
  61. Chan CB, Liu X, Jung DY, Jun JY, Luo HR, Kim JK, Ye K. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes. 2010 Apr; 59(4):883-93. PMID: 20068140.
    Citations: 19     Fields:    Translation:AnimalsCells
  62. Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43. PMID: 19561112.
    Citations: 18     Fields:    Translation:AnimalsCells
  63. Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HR. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol. 2009 Jun 01; 182(11):7190-200. PMID: 19454716.
    Citations: 13     Fields:    Translation:AnimalsCells
  64. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577. PMID: 19440552.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  65. Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41. PMID: 19286998.
    Citations: 25     Fields:    Translation:AnimalsCells
  66. Jia Y, Schurmans S, Luo HR. Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle. 2008 Sep 15; 7(18):2803-8. PMID: 18769148.
    Citations: 8     Fields:    Translation:AnimalsCells
  67. Jo H, Jia Y, Subramanian KK, Hattori H, Luo HR. Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol Cell Biol. 2008 Jul; 28(13):4285-99. PMID: 18458059.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  68. Luo HR, Loison F. Constitutive neutrophil apoptosis: mechanisms and regulation. Am J Hematol. 2008 Apr; 83(4):288-95. PMID: 17924549.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  69. Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell. 2008 Mar 28; 29(6):665-78. PMID: 18374643.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  70. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802.
    Citations: 16     Fields:    Translation:AnimalsCells
  71. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23. PMID: 18031698.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  72. Jia Y, Subramanian KK, Erneux C, Pouillon V, Hattori H, Jo H, You J, Zhu D, Schurmans S, Luo HR. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity. 2007 Sep; 27(3):453-67. PMID: 17825589.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  73. Maréchal Y, Pesesse X, Jia Y, Pouillon V, Pérez-Morga D, Daniel J, Izui S, Cullen PJ, Leo O, Luo HR, Erneux C, Schurmans S. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13978-83. PMID: 17709751.
    Citations: 27     Fields:    Translation:AnimalsCells
  74. Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE, Luo HR. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood. 2007 Jul 15; 110(2):640-50. PMID: 17420285.
    Citations: 16     Fields:    Translation:HumansCells
  75. Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SH. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. J Neurosci. 2007 Jan 17; 27(3):449-58. PMID: 17234578.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  76. Subramanian KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HR. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood. 2007 May 01; 109(9):4028-37. PMID: 17202315.
    Citations: 46     Fields:    Translation:AnimalsCells
  77. Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14836-41. PMID: 16988010.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  78. Huang Y, Man HY, Sekine-Aizawa Y, Han Y, Juluri K, Luo H, Cheah J, Lowenstein C, Huganir RL, Snyder SH. S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron. 2005 May 19; 46(4):533-40. PMID: 15944123.
    Citations: 64     Fields:    Translation:AnimalsCells
  79. Nagata E, Luo HR, Saiardi A, Bae BI, Suzuki N, Snyder SH. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem. 2005 Jan 14; 280(2):1634-40. PMID: 15533939.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  80. Iijima M, Huang YE, Luo HR, Vazquez F, Devreotes PN. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem. 2004 Apr 16; 279(16):16606-13. PMID: 14764604.
    Citations: 89     Fields:    Translation:AnimalsCells
  81. Luo HR, Hattori H, Hossain MA, Hester L, Huang Y, Lee-Kwon W, Donowitz M, Nagata E, Snyder SH. Akt as a mediator of cell death. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11712-7. PMID: 14504398.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  82. Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell. 2003 Sep 05; 114(5):559-72. PMID: 13678580.
    Citations: 79     Fields:    Translation:AnimalsCells
  83. Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SH. Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry. 2002 Feb 26; 41(8):2509-15. PMID: 11851397.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  84. Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH. Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature. 2002 Jan 31; 415(6871):541-4. PMID: 11823862.
    Citations: 50     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.