Harvard Catalyst Profiles

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K Frank Austen, M.D.

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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13). PMID: 33753496.
    Citations: 1     Fields:    
  2. Gotlib J, George TI, Carter MC, Austen KF, Bochner B, Dwyer DF, Lyons JJ, Hamilton MJ, Butterfield J, Bonadonna P, Weiler C, Galli SJ, Schwartz LB, Elberink HO, Maitland A, Theoharides T, Ustun C, Horny HP, Orfao A, Deininger M, Radia D, Jawhar M, Kluin-Nelemans H, Metcalfe DD, Arock M, Sperr WR, Valent P, Castells M, Akin C. Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference. J Allergy Clin Immunol. 2021 Jun; 147(6):2043-2052. PMID: 33745886.
    Citations:    Fields:    
  3. Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DF. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1). PMID: 32946563.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Kovanen PT, Hadzijusufovic E, Sadovnik I, Horny HP, Arock M, Schwartz LB, Austen KF, Metcalfe DD, Galli SJ. Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts. Theranostics. 2020; 10(23):10743-10768. PMID: 32929378.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  5. Weiler CR, Austen KF, Akin C, Barkoff MS, Bernstein JA, Bonadonna P, Butterfield JH, Carter M, Fox CC, Maitland A, Pongdee T, Mustafa SS, Ravi A, Tobin MC, Vliagoftis H, Schwartz LB. AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol. 2019 10; 144(4):883-896. PMID: 31476322.
    Citations: 8     Fields:    Translation:Humans
  6. Kanaoka Y, Austen KF. Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions. Adv Immunol. 2019; 142:65-84. PMID: 31296303.
    Citations: 8     Fields:    Translation:HumansAnimals
  7. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  8. Duah E, Teegala LR, Kondeti V, Adapala RK, Keshamouni VG, Kanaoka Y, Austen KF, Thodeti CK, Paruchuri S. Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. Proc Natl Acad Sci U S A. 2019 01 02; 116(1):199-204. PMID: 30559191.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Austen KF. Mentoring: An art and a responsibility. J Allergy Clin Immunol. 2018 03; 141(3):880-881. PMID: 29382599.
    Citations:    Fields:    Translation:Humans
  10. Austen KF, Gurish MF. Resolution of a human mast cell development conundrum. Blood. 2017 10 19; 130(16):1777-1778. PMID: 29051149.
    Citations: 2     Fields:    Translation:HumansCells
  11. Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Schwartz LB, Broesby-Olsen S, Bindslev-Jensen C, Kovanen PT, Galli SJ, Austen KF, Arber DA, Horny HP, Arock M, Metcalfe DD. Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Res. 2017 03 15; 77(6):1261-1270. PMID: 28254862.
    Citations: 48     Fields:    Translation:Humans
  12. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. PMID: 28011865.
    Citations: 49     Fields:    Translation:AnimalsCells
  13. McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y, Austen KF, Powell WS, Martin JG. CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma. J Immunol. 2016 07 01; 197(1):266-77. PMID: 27226094.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938.
    Citations: 38     Fields:    Translation:AnimalsCells
  15. Dwyer DF, Barrett NA, Austen KF. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016 Jul; 17(7):878-87. PMID: 27135604.
    Citations: 101     Fields:    Translation:AnimalsCells
  16. Austen K, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, Grashoff C. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015 Dec; 17(12):1597-606. PMID: 26523364.
    Citations: 90     Fields:    Translation:AnimalsCells
  17. Barrett NA, Austen KF. Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis. Immunity. 2015 Oct 20; 43(4):626-8. PMID: 26488812.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Bankova LG, Dwyer DF, Liu AY, Austen KF, Gurish MF. Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice. Mucosal Immunol. 2015 May; 8(3):596-606. PMID: 25291985.
    Citations: 22     Fields:    Translation:AnimalsCells
  19. Dwyer DF, Woodruff MC, Carroll MC, Austen KF, Gurish MF. B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake. J Immunol. 2014 Jul 15; 193(2):529-39. PMID: 24928991.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  20. Austen KF. K. Frank Austen. Boston, Mass., USA. Chem Immunol Allergy. 2014; 100:340-1. PMID: 24925415.
    Citations:    Fields:    Translation:Humans
  21. Bankova LG, Lezcano C, Pejler G, Stevens RL, Murphy GF, Austen KF, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20. PMID: 24523504.
    Citations: 15     Fields:    Translation:AnimalsCells
  22. Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71. PMID: 24453247.
    Citations: 20     Fields:    Translation:AnimalsCells
  23. Kanaoka Y, Maekawa A, Austen KF. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013 Apr 19; 288(16):10967-72. PMID: 23504326.
    Citations: 63     Fields:    Translation:Animals
  24. Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, Beaupré J, Lewis CN, Austen KF, Schulte S, Hornick JL, Geha RS, Oyoshi MK. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6. PMID: 23374269.
    Citations: 39     Fields:    Translation:AnimalsCells
  25. Liu AY, Dwyer DF, Jones TG, Bankova LG, Shen S, Katz HR, Austen KF, Gurish MF. Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6. J Immunol. 2013 Feb 15; 190(4):1758-66. PMID: 23319739.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 01; 189(9):4556-65. PMID: 23002438.
    Citations: 16     Fields:    Translation:AnimalsCells
  27. Gurish MF, Austen KF. Developmental origin and functional specialization of mast cell subsets. Immunity. 2012 Jul 27; 37(1):25-33. PMID: 22840841.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  28. Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7. PMID: 22416124.
    Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  29. Katz HR, Austen KF. Mast cell deficiency, a game of kit and mouse. Immunity. 2011 Nov 23; 35(5):668-70. PMID: 22118523.
    Citations: 17     Fields:    
  30. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11. PMID: 21934409.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Xing W, Austen KF, Gurish MF, Jones TG. Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14210-5. PMID: 21825171.
    Citations: 46     Fields:    Translation:AnimalsCellsPHPublic Health
  32. Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, Yamamoto M, Kanaoka Y, Lam BK, Austen KF, Miyano M. The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem. 2011 May 06; 286(18):16392-401. PMID: 21454538.
    Citations: 11     Fields:    Translation:HumansCells
  33. Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604. PMID: 21357742.
    Citations: 76     Fields:    Translation:AnimalsCells
  34. Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90. PMID: 21076070.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Jones TG, Finkelman FD, Austen KF, Gurish MF. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol. 2010 Aug 01; 185(3):1804-11. PMID: 20601599.
    Citations: 9     Fields:    Translation:AnimalsCells
  36. Maekawa A, Xing W, Austen KF, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010 Aug 01; 185(3):1846-54. PMID: 20574000.
    Citations: 15     Fields:    Translation:AnimalsCells
  37. Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CL. The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol. 2010 Jun 01; 184(11):6114-23. PMID: 20427772.
    Citations: 29     Fields:    Translation:AnimalsCells
  38. Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol. 2009 Oct 15; 183(8):5251-60. PMID: 19783672.
    Citations: 41     Fields:    Translation:AnimalsCells
  39. Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity. 2009 Sep 18; 31(3):425-37. PMID: 19766085.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  40. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6. PMID: 19647860.
    Citations: 33     Fields:    Translation:HumansAnimals
  41. Maekawa A, Balestrieri B, Austen KF, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11685-90. PMID: 19561298.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  42. Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009 Jan 15; 182(2):1119-28. PMID: 19124755.
    Citations: 95     Fields:    Translation:AnimalsCells
  43. Blossom DB, Kallen AJ, Patel PR, Elward A, Robinson L, Gao G, Langer R, Perkins KM, Jaeger JL, Kurkjian KM, Jones M, Schillie SF, Shehab N, Ketterer D, Venkataraman G, Kishimoto TK, Shriver Z, McMahon AW, Austen KF, Kozlowski S, Srinivasan A, Turabelidze G, Gould CV, Arduino MJ, Sasisekharan R. Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med. 2008 Dec 18; 359(25):2674-84. PMID: 19052120.
    Citations: 60     Fields:    Translation:HumansPHPublic Health
  44. Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16695-700. PMID: 18931305.
    Citations: 52     Fields:    Translation:Animals
  45. Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing JC, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey GS, Fraser B, Roy S, Rogers-Cotrone T, Buhse L, Whary M, Fox J, Nasr M, Dal Pan GJ, Shriver Z, Langer RS, Venkataraman G, Austen KF, Woodcock J, Sasisekharan R. Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med. 2008 Jun 05; 358(23):2457-67. PMID: 18434646.
    Citations: 138     Fields:    Translation:HumansAnimalsPHPublic Health
  46. Austen KF. The cysteinyl leukotrienes: where do they come from? What are they? Where are they going? Nat Immunol. 2008 Feb; 9(2):113-5. PMID: 18204420.
    Citations: 11     Fields:    Translation:HumansAnimals
  47. Austen KF. Doing what I like. Annu Rev Immunol. 2008; 26:1-28. PMID: 17877459.
    Citations:    Fields:    Translation:Cells