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Austen, K
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K Frank Austen
Title
Astrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine, Emeritus
Institution
Brigham and Women's Hospital
Department
Emeritus
Address
Brigham and Women
Allergy & Immunology, BTM, Room 5002X
60 Fenwood Rd
Boston MA 02115
Phone
617/525-1300
Fax
617/525-1310
vCard
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selected publications
|
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
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Most Cited
|
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Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Dwyer DF
,
Austen KF
. The Discovery of Discrete Developmental Pathways Directing Constitutive and Induced Mast Cells in Mice. J Immunol. 2021 07 15; 207(2):359-361.
PMID:
34644258
.
Citations:
1
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Voisin T, Perner C, Messou MA, Shiers S,
Ualiyeva S
, Kanaoka Y, Price TJ,
Sokol CL
,
Bankova LG
,
Austen KF
,
Chiu IM
. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
PMID:
33753496
.
Citations:
12
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Gotlib J, George TI, Carter MC,
Austen KF
, Bochner B,
Dwyer DF
, Lyons JJ,
Hamilton MJ
, Butterfield J, Bonadonna P, Weiler C, Galli SJ, Schwartz LB, Elberink HO, Maitland A, Theoharides T, Ustun C, Horny HP, Orfao A, Deininger M, Radia D, Jawhar M, Kluin-Nelemans H, Metcalfe DD, Arock M, Sperr WR, Valent P,
Castells M
, Akin C. Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference. J Allergy Clin Immunol. 2021 06; 147(6):2043-2052.
PMID:
33745886
; PMCID:
PMC9521380
.
Citations:
2
Fields:
All
Allergy and Immunology
Translation:
Humans
Derakhshan T
,
Samuchiwal SK
, Hallen N,
Bankova LG
,
Boyce JA
,
Barrett NA
,
Austen KF
,
Dwyer DF
. Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1).
PMID:
32946563
.
Citations:
5
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Kovanen PT, Hadzijusufovic E, Sadovnik I, Horny HP, Arock M, Schwartz LB,
Austen KF
, Metcalfe DD, Galli SJ. Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts. Theranostics. 2020; 10(23):10743-10768.
PMID:
32929378
.
Citations:
26
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Weiler CR,
Austen KF
, Akin C, Barkoff MS, Bernstein JA, Bonadonna P, Butterfield JH, Carter M, Fox CC, Maitland A, Pongdee T, Mustafa SS, Ravi A, Tobin MC, Vliagoftis H, Schwartz LB. AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol. 2019 10; 144(4):883-896.
PMID:
31476322
.
Citations:
16
Fields:
All
Allergy and Immunology
Translation:
Humans
Kanaoka Y,
Austen KF
. Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions. Adv Immunol. 2019; 142:65-84.
PMID:
31296303
.
Citations:
11
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Leyva-Castillo JM
, Galand C, Kam C, Burton O, Gurish M,
Musser MA
,
Goldsmith JD
,
Hait E
,
Nurko S
, Brombacher F, Dong C, Finkelman FD,
Lee RT
, Ziegler S,
Chiu I
,
Austen KF
,
Geha RS
. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4.
PMID:
31027995
; PMCID:
PMC6531322
.
Citations:
54
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Duah E, Teegala LR, Kondeti V, Adapala RK, Keshamouni VG, Kanaoka Y,
Austen KF
, Thodeti CK, Paruchuri S. Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. Proc Natl Acad Sci U S A. 2019 01 02; 116(1):199-204.
PMID:
30559191
.
Citations:
19
Fields:
Sci
Science
Translation:
Animals
Cells
Austen KF
. Mentoring: An art and a responsibility. J Allergy Clin Immunol. 2018 03; 141(3):880-881.
PMID:
29382599
.
Citations:
Fields:
All
Allergy and Immunology
Translation:
Humans
Austen KF
, Gurish MF. Resolution of a human mast cell development conundrum. Blood. 2017 10 19; 130(16):1777-1778.
PMID:
29051149
.
Citations:
2
Fields:
Hem
Hematology
Translation:
Humans
Cells
Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Schwartz LB, Broesby-Olsen S, Bindslev-Jensen C, Kovanen PT, Galli SJ,
Austen KF
, Arber DA, Horny HP, Arock M, Metcalfe DD. Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Res. 2017 03 15; 77(6):1261-1270.
PMID:
28254862
; PMCID:
PMC5354959
.
Citations:
59
Fields:
Neo
Neoplasms
Translation:
Humans
von Moltke J, O'Leary CE,
Barrett NA
, Kanaoka Y,
Austen KF
, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37.
PMID:
28011865
; PMCID:
PMC5206504
.
Citations:
67
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y,
Austen KF
, Powell WS, Martin JG. CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma. J Immunol. 2016 07 01; 197(1):266-77.
PMID:
27226094
.
Citations:
7
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Bankova LG
, Lai J, Yoshimoto E,
Boyce JA
,
Austen KF
, Kanaoka Y,
Barrett NA
. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7.
PMID:
27185938
; PMCID:
PMC4896673
.
Citations:
47
Fields:
Sci
Science
Translation:
Animals
Cells
Dwyer DF
,
Barrett NA
,
Austen KF
. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016 Jul; 17(7):878-87.
PMID:
27135604
; PMCID:
PMC5045264
.
Citations:
131
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Austen K
, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, Grashoff C. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015 Dec; 17(12):1597-606.
PMID:
26523364
; PMCID:
PMC4662888
.
Citations:
126
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Barrett NA
,
Austen KF
. Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis. Immunity. 2015 Oct 20; 43(4):626-8.
PMID:
26488812
.
Citations:
1
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Bankova LG
,
Dwyer DF
, Liu AY,
Austen KF
, Gurish MF. Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice. Mucosal Immunol. 2015 May; 8(3):596-606.
PMID:
25291985
.
Citations:
29
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Dwyer DF
, Woodruff MC,
Carroll MC
,
Austen KF
, Gurish MF. B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake. J Immunol. 2014 Jul 15; 193(2):529-39.
PMID:
24928991
; PMCID:
PMC4203309
.
Citations:
7
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
PH
Public Health
Austen KF
. K. Frank Austen. Boston, Mass., USA. Chem Immunol Allergy. 2014; 100:340-1.
PMID:
24925415
.
Citations:
Fields:
All
Allergy and Immunology
Bio
Biochemistry
Translation:
Humans
Bankova LG
, Lezcano C, Pejler G,
Stevens RL
,
Murphy GF
,
Austen KF
, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20.
PMID:
24523504
; PMCID:
PMC3970423
.
Citations:
17
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Parsons MW, Li L, Wallace AM, Lee MJ,
Katz HR
, Fernandez JM, Saijo S, Iwakura Y,
Austen KF
, Kanaoka Y,
Barrett NA
. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71.
PMID:
24453247
; PMCID:
PMC4024442
.
Citations:
22
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Kanaoka Y, Maekawa A,
Austen KF
. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013 Apr 19; 288(16):10967-72.
PMID:
23504326
.
Citations:
76
Fields:
Bio
Biochemistry
Translation:
Animals
Bartnikas LM
, Gurish MF, Burton OT, Leisten S, Janssen E,
Oettgen HC
, Beaupré J, Lewis CN,
Austen KF
,
Schulte S
,
Hornick JL
,
Geha RS
,
Oyoshi MK
. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6.
PMID:
23374269
; PMCID:
PMC3587010
.
Citations:
50
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Liu AY,
Dwyer DF
, Jones TG,
Bankova LG
, Shen S,
Katz HR
,
Austen KF
, Gurish MF. Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6. J Immunol. 2013 Feb 15; 190(4):1758-66.
PMID:
23319739
; PMCID:
PMC3563837
.
Citations:
10
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Barrett NA
, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW,
Austen KF
, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 01; 189(9):4556-65.
PMID:
23002438
; PMCID:
PMC3478400
.
Citations:
17
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Gurish MF,
Austen KF
. Developmental origin and functional specialization of mast cell subsets. Immunity. 2012 Jul 27; 37(1):25-33.
PMID:
22840841
.
Citations:
124
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Oyoshi MK
, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN,
Austen KF
,
Geha RS
. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7.
PMID:
22416124
.
Citations:
23
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
PH
Public Health
Katz HR
,
Austen KF
. Mast cell deficiency, a game of kit and mouse. Immunity. 2011 Nov 23; 35(5):668-70.
PMID:
22118523
.
Citations:
21
Fields:
All
Allergy and Immunology
Petersen B,
Austen KF
, Bloch KD, Hotta Y,
Ichinose F
, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11.
PMID:
21934409
; PMCID:
PMC3194098
.
Citations:
4
Fields:
Ane
Anesthesiology
Translation:
Animals
Cells
Xing W,
Austen KF
, Gurish MF, Jones TG. Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14210-5.
PMID:
21825171
.
Citations:
54
Fields:
Sci
Science
Translation:
Animals
Cells
PH
Public Health
Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, Yamamoto M, Kanaoka Y, Lam BK,
Austen KF
, Miyano M. The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem. 2011 May 06; 286(18):16392-401.
PMID:
21454538
.
Citations:
12
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Barrett NA
, Rahman OM, Fernandez JM, Parsons MW, Xing W,
Austen KF
, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604.
PMID:
21357742
.
Citations:
83
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR,
Moore FD
,
Stevens RL
, Adachi R,
Austen KF
, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90.
PMID:
21076070
; PMCID:
PMC3058366
.
Citations:
33
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Jones TG, Finkelman FD,
Austen KF
, Gurish MF. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol. 2010 Aug 01; 185(3):1804-11.
PMID:
20601599
; PMCID:
PMC2951001
.
Citations:
10
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Maekawa A, Xing W,
Austen KF
, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010 Aug 01; 185(3):1846-54.
PMID:
20574000
; PMCID:
PMC4014011
.
Citations:
18
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Collington SJ, Hallgren J, Pease JE, Jones TG,
Rollins BJ
, Westwick J,
Austen KF
, Williams TJ, Gurish MF, Weller CL. The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol. 2010 Jun 01; 184(11):6114-23.
PMID:
20427772
; PMCID:
PMC2956277
.
Citations:
36
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells