Harvard Catalyst Profiles

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George Francis Murphy, M.D.

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Biography
1976
Induction
1976
Sheard-Sanford Award (Honorable Men.)
1976
Woodbury Alumni Award, Medicine
1982
Election
1984
Benjamin Castleman Award
1987
John Morgan Society
1987
Long Course Director, Service Award
1988
Arthur K. Doolittle Award
1988 - 1989
Diagnostic Pathology Faculty
1988
Election
1988
Leaders' Society
1991
Election to Organization
1991
Herman Beerman Endowed Chair
1992
Teaching Award, Class of 1995
1992
Whitaker Health Sciences Foundation Award
1993
Attending Teaching Award, Dermatology
1993
Merlin Trumbull Lectureship
1994
Keynote Address
1994 - 1998
Short Course Faculty
1995
Faculty Teaching Award, Class of 1995
1997
Chair, Board of Directors
1997
Institutional Representative
1997
U.S. Delegate
1998
Schleifstein Lectureship
1999
Keynote Address
1999
Quest Visiting Professorship in Pathology
2000
Proctor&Gamble Lectureship
2001
Expert Advisory Panel on Skin Tumors
2005
Honorary Master of Arts Degree
2006
Distinguished Academic Achievement Award
2007
Walter Putchar Annual Lectureship

Overview
Dr. Murphy’s program in funded basic investigation has been ongoing continuously since 1984 in the form of R01 grants and via participation in Program Project initiatives. The current focus of Dr. Murphy's research is elucidation of the cellular and molecular mechanisms responsible for cutaneous cytotoxic reactions, including graft-versus-host disease subsequent to allogeneic stem cell transplantation for childhood and adult leukemia/lymphoma. In addition, a major collaboration involving Brigham Plastic and Reconstructive Surgery and the MIT Biomaterials Department focuses on tissue stem cell biology and cutaneous regenerative medicine. One goal of this work is to define pathways responsible for scarless regeneration that typifies fetal, but not post-natal, human skin. Dr. Murphy also serves as the Director of the Tissue and Cell Analysis Core for the Harvard Skin Disease Research Center (SDRC) as well as for the Biospecimen Access and Analysis Core for the Harvard Specialized Program for Research Excellence (SPORE) in skin cancer. For research contributions concerning Langerhans cell histiocytosis, he received the Benjamin Castleman Award of the International Academy of Pathology. In 1991, he was elected into the American Society for Clinical Investigation for which he also served as an Institutional Representative. His work in the area of neuropeptide regulation of Langerhans cell function was recognized as one of the 50 most significant scientific breakthroughs worldwide for the year 1993 by the magazine, Discover. His most recent collaborative interaction with the laboratory of Dr. Markus Frank of Boston’s Children’s Hospital has recently fostered the first biomarker identification and therapeutically relevant targeting of melanoma stem cells (January 2008 cover article, Nature). He has served as a regular term member of the General Medicine A Study Section for the NIH.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01AI106684 (RAY, ANURADHA) May 15, 2015 - May 31, 2020
    NIH/NIAID
    Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma
    Role: Co-Principal Investigator
  2. P01AI108545 (VIGNALI, DARIO AA) May 15, 2015 - Apr 30, 2020
    NIH/NIAID
    Synergies among inhibitory receptors in tolerance, cancer and antiviral immunity
    Role: Co-Principal Investigator
  3. R01CA158467 (FRANK, MARKUS H.) Sep 1, 2012 - Jun 30, 2018
    NIH
    Immunology of human malignant melanoma initiating cells
    Role: Co-Principal Investigator
  4. P50CA093683 (KUPPER, THOMAS S.) Sep 30, 2001 - Jan 31, 2014
    NIH
    SPORE in Skin Cancer
    Role: Co-Principal Investigator
  5. P01CA077401 (FLOMENBERG, NEAL) Apr 1, 1999 - Mar 31, 2004
    NIH/NCI
    BIOLOGIC &CLINICAL PROPERTIES OF CD4 STRUCTURAL ANALOGS
    Role: Co-Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.