Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Patrick Lee Purdon, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R42DA053075 (PURDON, PATRICK L.) Sep 15, 2020 - May 31, 2021
    NIH
    Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
    Role: Principal Investigator
  2. R42AG066325 (LE MAU, TUAN) Feb 1, 2020 - Feb 28, 2023
    NIH
    Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
    Role: Principal Investigator
  3. R21DA048323 (PURDON, PATRICK L.) Apr 1, 2019 - Mar 31, 2021
    NIH
    A pilot study to characterize brain dynamic biomarkers of fentanyl for opioid overdose monitoring
    Role: Principal Investigator
  4. R01AG054081 (PURDON, PATRICK L.) Jun 1, 2017 - May 31, 2022
    NIH
    Noninvasive Low-cost Biomarkers for Preclinical Diagnosis and Longitudinal Tracking of Alzheimer's Disease Using Sleep and Resting State EEG
    Role: Principal Investigator
  5. R01AG056015 (PURDON, PATRICK L.) Apr 15, 2017 - Mar 31, 2022
    NIH
    The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weiner VS, Zhou DW, Kahali P, Stephen EP, Peterfreund RA, Aglio LS, Szabo MD, Eskandar EN, Salazar-Gomez AF, Sampson AL, Cash SS, Brown EN, Purdon PL. Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness. Proc Natl Acad Sci U S A. 2023 Mar 14; 120(11):e2207831120. PMID: 36897972.
    Citations:    Fields:    
  2. Santa Cruz Mercado LA, Lee JM, Liu R, Deng H, Johnson JJ, Chen AL, He M, Chung ER, Bharadwaj KM, Houle TT, Purdon PL, Liu CA. Age-Dependent Electroencephalogram Features in Infants Under Spinal Anesthesia Appear to Mirror Physiologic Sleep in the Developing Brain: A Prospective Observational Study. Anesth Analg. 2023 Mar 07. PMID: 36881544.
    Citations:    Fields:    
  3. Bong CL, Balanza GA, Khoo CE, Tan JS, Desel T, Purdon PL. A Narrative Review Illustrating the Clinical Utility of Electroencephalogram-Guided Anesthesia Care in Children. Anesth Analg. 2022 Dec 19. PMID: 36729437.
    Citations:    Fields:    
  4. Koch S, Egaña JI, Penna A, Orser BA, Purdon PL, Gutiérrez R. Editorial: Innovative approaches for assessing and improving perioperative neurocognitive disorders. Front Aging Neurosci. 2022; 14:1098250. PMID: 36570543; PMCID: PMC9783617.
    Citations:    
  5. Chao JY, Gutiérrez R, Legatt AD, Yozawitz EG, Lo Y, Adams DC, Delphin ES, Shinnar S, Purdon PL. Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants. Anesth Analg. 2022 12 01; 135(6):1207-1216. PMID: 35041633; PMCID: PMC9276847.
    Citations: 1     Fields:    Translation:Humans
  6. Soulat H, Stephen EP, Beck AM, Purdon PL. State space methods for phase amplitude coupling analysis. Sci Rep. 2022 09 24; 12(1):15940. PMID: 36153353; PMCID: PMC9509338.
    Citations:    Fields:    Translation:HumansAnimals
  7. Balanza GA, Bharadwaj KM, Mullen AC, Beck AM, Work EC, McGovern FJ, Houle TT, Eric TP, Purdon PL. An electroencephalogram biomarker of fentanyl drug effects. PNAS Nexus. 2022 Sep; 1(4):pgac158. PMID: 36329725; PMCID: PMC9615126.
    Citations:    
  8. Long MHY, Lim EHL, Balanza GA, Allen JC, Purdon PL, Bong CL. Sevoflurane requirements during electroencephalogram (EEG)-guided vs standard anesthesia Care in Children: A randomized controlled trial. J Clin Anesth. 2022 10; 81:110913. PMID: 35772250.
    Citations:    Fields:    Translation:Humans
  9. Paixao L, Sun H, Hogan J, Hartnack K, Westmeijer M, Neelagiri A, Zhou DW, McClain LM, Kimchi EY, Purdon PL, Akeju O, Westover MB. ICU delirium burden predicts functional neurologic outcomes. PLoS One. 2021; 16(12):e0259840. PMID: 34855749; PMCID: PMC8638853.
    Citations:    Fields:    Translation:Humans
  10. Whitaker EE, Chao JY, Holmes GL, Legatt AD, Yozawitz EG, Purdon PL, Shinnar S, Williams RK. Electroencephalographic assessment of infant spinal anesthesia: A pilot prospective observational study. Paediatr Anaesth. 2021 Nov; 31(11):1179-1186. PMID: 34510633; PMCID: PMC8530954.
    Citations: 1     Fields:    Translation:Humans
  11. Subramanian S, Purdon PL, Barbieri R, Brown EN. A Model-Based Framework for Assessing the Physiologic Structure of Electrodermal Activity. IEEE Trans Biomed Eng. 2021 09; 68(9):2833-2845. PMID: 33822719.
    Citations: 4     Fields:    Translation:Humans
  12. Subramanian S, Purdon PL, Barbieri R, Brown EN. Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness. PLoS One. 2021; 16(8):e0254053. PMID: 34379623.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  13. Subramanian S, Purdon PL, Barbieri R, Brown EN. Elementary integrate-and-fire process underlies pulse amplitudes in Electrodermal activity. PLoS Comput Biol. 2021 07; 17(7):e1009099. PMID: 34232965; PMCID: PMC8289084.
    Citations:    Fields:    Translation:Humans
  14. Gutiérrez RG, Egaña JI, Maldonado FA, Sáez IA, Reyes FI, Soulat H, Purdon PL, Penna A. Association Between Lower Preoperative Cognition With Intraoperative Electroencephalographic Features Consistent With Deep States of Anesthesia in Older Patients: An Observational Cohort Study. Anesth Analg. 2021 07 01; 133(1):205-214. PMID: 33177327.
    Citations: 2     Fields:    Translation:Humans
  15. Abel JH, Badgeley MA, Meschede-Krasa B, Schamberg G, Garwood IC, Lecamwasam K, Chakravarty S, Zhou DW, Keating M, Purdon PL, Brown EN. Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia. PLoS One. 2021; 16(5):e0246165. PMID: 33956800.
    Citations: 4     Fields:    Translation:Humans
  16. Abel JH, Badgeley MA, Baum TE, Chakravarty S, Purdon PL, Brown EN. Constructing a control-ready model of EEG signal during general anesthesia in humans. Proc IFAC World Congress. 2020; 53(2):15870-15876. PMID: 34184002.
    Citations:    
  17. He M, Liu F, Nummenmaa A, Hämäläinen M, Dickerson BC, Purdon PL. Age-Related EEG Power Reductions Cannot Be Explained by Changes of the Conductivity Distribution in the Head Due to Brain Atrophy. Front Aging Neurosci. 2021; 13:632310. PMID: 33679380.
    Citations: 2     
  18. Liu F, Wang L, Lou Y, Li RC, Purdon PL. Probabilistic Structure Learning for EEG/MEG Source Imaging With Hierarchical Graph Priors. IEEE Trans Med Imaging. 2021 01; 40(1):321-334. PMID: 32956052.
    Citations: 4     Fields:    
  19. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 11; 131(5):1529-1539. PMID: 33079876; PMCID: PMC7553194.
    Citations: 15     Fields:    Translation:Humans
  20. Brandt SP, Walsh EC, Cornelissen L, Lee JM, Berde C, Shank ES, Purdon PL. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 10; 131(4):1043-1056. PMID: 32925322; PMCID: PMC7467151.
    Citations: 2     Fields:    Translation:Humans
  21. Brandt SP, Walsh EC, Cornelissen L, Lee JM, Berde C, Shank ES, Purdon PL. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 Aug 17. PMID: 32833713.
    Citations:    
  22. Stephen EP, Hotan GC, Pierce ET, Harrell PG, Walsh JL, Brown EN, Purdon PL. Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness. Sci Rep. 2020 08 13; 10(1):13701. PMID: 32792556.
    Citations: 3     Fields:    Translation:Humans
  23. Subramanian S, Barbieri R, Purdon PL, Brown EN. Detecting Loss and Regain of Consciousness during Propofol Anesthesia using Multimodal Indices of Autonomic State. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:824-827. PMID: 33018112.
    Citations: 2     Fields:    Translation:Humans
  24. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 May 14. PMID: 32427658.
    Citations:    Fields:    
  25. Chan MTV, Hedrick TL, Egan TD, García PS, Koch S, Purdon PL, Ramsay MA, Miller TE, McEvoy MD, Gan TJ. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on the Role of Neuromonitoring in Perioperative Outcomes: Electroencephalography. Anesth Analg. 2020 05; 130(5):1278-1291. PMID: 31764163.
    Citations: 22     Fields:    Translation:Humans
  26. Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, Evered L, Scott DA, Wang NY, Brown CH, Oh E, Purdon P, Inouye S, Berger M, Whittington RA, Price CC, Deiner S. Corrigendum to 'State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018' (Br J Anaesth 2019; 123: 464-478). Br J Anaesth. 2019 12; 123(6):917. PMID: 31591017.
    Citations:    Fields:    
  27. Mahanna-Gabrielli E, Schenning KJ, Eriksson LI, Browndyke JN, Wright CB, Culley DJ, Evered L, Scott DA, Wang NY, Brown CH, Oh E, Purdon P, Inouye S, Berger M, Whittington RA, Price CC, Deiner S. State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018. Br J Anaesth. 2019 10; 123(4):464-478. PMID: 31439308.
    Citations: 41     Fields:    Translation:Humans
  28. Liu F, Stephen EP, Prerau MJ, Purdon PL. Sparse Multi-task Inverse Covariance Estimation for Connectivity Analysis in EEG Source Space. Int IEEE EMBS Conf Neural Eng. 2019 Mar; 2019:299-302. PMID: 31156761; PMCID: PMC6541022.
    Citations: 3     
  29. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. PLoS One. 2018; 13(10):e0205789. PMID: 30379935.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  30. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations: 11     Fields:    Translation:Humans
  31. Stokes PA, Purdon PL. Reply to Barnett et al.: Regarding interpretation of Granger causality analyses. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6678-E6679. PMID: 29991603; PMCID: PMC6055186.
    Citations: 2     Fields:    
  32. Beck AM, Stephen EP, Purdon PL. State Space Oscillator Models for Neural Data Analysis. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:4740-4743. PMID: 30441408; PMCID: PMC6394839.
    Citations: 3     Fields:    
  33. Sun H, Nagaraj SB, Akeju O, Purdon PL, Westover BM. Brain Monitoring of Sedation in the Intensive Care Unit Using a Recurrent Neural Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4. PMID: 30440304; PMCID: PMC6775766.
    Citations: 4     Fields:    Translation:Humans
  34. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. PMID: 29988455; PMCID: PMC6024139.
    Citations: 7     
  35. Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun; 120(6):1274-1286. PMID: 29793594.
    Citations: 14     Fields:    Translation:Humans
  36. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327. PMID: 29935587; PMCID: PMC6617959.
    Citations: 7     Fields:    
  37. Nagaraj SB, McClain LM, Boyle EJ, Zhou DW, Ramaswamy SM, Biswal S, Akeju O, Purdon PL, Westover MB. Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition. IEEE Trans Biomed Eng. 2018 12; 65(12):2684-2691. PMID: 29993386; PMCID: PMC6424570.
    Citations: 5     Fields:    Translation:Humans
  38. Chakravarty S, Nikolaeva K, Kishnan D, Flores FJ, Purdon PL, Brown EN. Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. Health Innov Point Care Conf. 2017 Nov; 2017:44-47. PMID: 32803192; PMCID: PMC7426181.
    Citations: 2     
  39. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol. 2017 12; 13(12):e1005879. PMID: 29227992.
    Citations: 16     Fields:    Translation:Humans
  40. Krishnaswamy P, Obregon-Henao G, Ahveninen J, Khan S, Babadi B, Iglesias JE, Hämäläinen MS, Purdon PL. Sparsity enables estimation of both subcortical and cortical activity from MEG and EEG. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):E10465-E10474. PMID: 29138310; PMCID: PMC5715738.
    Citations: 38     Fields:    Translation:Humans
  41. Pirondini E, Babadi B, Obregon-Henao G, Lamus C, Malik WQ, Hamalainen MS, Purdon PL. Computationally Efficient Algorithms for Sparse, Dynamic Solutions to the EEG Source Localization Problem. IEEE Trans Biomed Eng. 2018 06; 65(6):1359-1372. PMID: 28920892.
    Citations: 12     Fields:    Translation:Humans
  42. Stokes PA, Purdon PL. A study of problems encountered in Granger causality analysis from a neuroscience perspective. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):E7063-E7072. PMID: 28778996; PMCID: PMC5576801.
    Citations: 72     Fields:    Translation:Humans
  43. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    Citations: 21     Fields:    Translation:Humans
  44. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668. PMID: 28743752; PMCID: PMC5558998.
    Citations: 54     Fields:    Translation:Animals
  45. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:4313-4316. PMID: 29060851; PMCID: PMC5835010.
    Citations: 1     Fields:    Translation:Humans
  46. Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB. Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability. Crit Care Med. 2017 Jul; 45(7):e683-e690. PMID: 28441231; PMCID: PMC5474145.
    Citations: 12     Fields:    Translation:Humans
  47. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601; PMCID: PMC5447687.
    Citations: 20     
  48. Prerau MJ, Brown RE, Bianchi MT, Ellenbogen JM, Purdon PL. Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis. Physiology (Bethesda). 2017 01; 32(1):60-92. PMID: 27927806.
    Citations: 68     Fields:    Translation:HumansAnimals
  49. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 10; 64(10):2462-2474. PMID: 28026746.
    Citations: 1     Fields:    Translation:HumansCells
  50. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  51. Nagaraj SB, McClain LM, Zhou DW, Biswal S, Rosenthal ES, Purdon PL, Westover MB. Automatic Classification of Sedation Levels in ICU Patients Using Heart Rate Variability. Crit Care Med. 2016 Sep; 44(9):e782-9. PMID: 27035240; PMCID: PMC4987179.
    Citations: 13     Fields:    Translation:Humans
  52. Nagaraj SB, Ramaswamy SM, Biswal S, Boyle EJ, Zhou DW, Mcclain LM, Rosenthal ES, Purdon PL, Westover MB. Heart rate variability as a biomarker for sedation depth estimation in ICU patients. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:6397-6400. PMID: 28269712; PMCID: PMC5478422.
    Citations:    Fields:    Translation:Humans
  53. Nagaraj SB, Ramaswamy SM, Biswal S, Boyle EJ, Zhou DW, Mcclain LM, Rosenthal ES, Purdon PL, Westover MB, Nagaraj SB, Ramaswamy SM, Biswal S, Boyle EJ, Zhou DW, Mcclain LM, Rosenthal ES, Purdon PL, Westover MB, Westover MB, Nagaraj SB, Biswal S, Ramaswamy SM, Mcclain LM, Zhou DW, Boyle EJ, Purdon PL, Rosenthal ES. Heart rate variability as a biomarker for sedation depth estimation in ICU patients. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:6397-6400. PMID: 28227974.
    Citations:    
  54. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861.
    Citations: 54     Fields:    Translation:Humans
  55. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867.
    Citations: 24     Fields:    Translation:Humans
  56. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60. PMID: 26275092; PMCID: PMC4573341.
    Citations: 184     Fields:    Translation:Humans
  57. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863; PMCID: PMC4625800.
    Citations: 2     Fields:    Translation:Humans
  58. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    Citations: 6     Fields:    Translation:Animals
  59. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412. PMID: 26151100.
    Citations: 11     Fields:    Translation:Humans
  60. Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. Br J Anaesth. 2015 Jul; 115 Suppl 1:i58-i65. PMID: 26174302.
    Citations: 15     Fields:    Translation:Animals
  61. Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL. Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. Br J Anaesth. 2015 Jul; 115 Suppl 1:i66-i76. PMID: 26174303.
    Citations: 28     Fields:    Translation:Humans
  62. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300.
    Citations: 102     Fields:    Translation:Humans
  63. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526.
    Citations: 33     Fields:    Translation:Humans
  64. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489.
    Citations: 22     Fields:    Translation:Humans
  65. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004. PMID: 26020243.
    Citations: 4     Fields:    Translation:Humans
  66. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    Citations: 15     Fields:    Translation:Humans
  67. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:534-7. PMID: 26736317; PMCID: PMC4870018.
    Citations: 3     Fields:    Translation:Humans
  68. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7430-3. PMID: 26738009; PMCID: PMC4876722.
    Citations: 7     Fields:    Translation:Humans
  69. Zhou DW, Westover MB, McClain LM, Nagaraj SB, Bajwa EK, Quraishi SA, Akeju O, Cobb JP, Purdon PL. Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7258-61. PMID: 26737967; PMCID: PMC4870011.
    Citations: 1     Fields:    Translation:Humans
  70. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45. PMID: 25468968; PMCID: PMC4273341.
    Citations: 8     Fields:    Translation:Humans
  71. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 66     Fields:    Translation:Humans
  72. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374; PMCID: PMC4206606.
    Citations: 95     Fields:    Translation:Humans
  73. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999; PMCID: PMC4304638.
    Citations: 64     Fields:    Translation:Humans
  74. Prerau MJ, Hartnack KE, Obregon-Henao G, Sampson A, Merlino M, Gannon K, Bianchi MT, Ellenbogen JM, Purdon PL. Tracking the sleep onset process: an empirical model of behavioral and physiological dynamics. PLoS Comput Biol. 2014 Oct; 10(10):e1003866. PMID: 25275376.
    Citations: 24     Fields:    Translation:Humans
  75. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gómez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods. 2014 Apr 30; 227:65-74. PMID: 24530701.
    Citations: 6     Fields:    Translation:Humans
  76. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45. PMID: 24431442.
    Citations: 50     Fields:    Translation:Humans
  77. Babadi B, Ba D, Purdon PL, Brown EN. Convergence and Stability of a Class of Iteratively Re-weighted Least Squares Algorithms for Sparse Signal Recovery in the Presence of Noise. IEEE Trans Signal Process. 2013 Oct 30; 62(1):183-195. PMID: 26549965; PMCID: PMC4636042.
    Citations: 6     
  78. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology. 2013 Oct; 119(4):848-60. PMID: 23770601; PMCID: PMC3857134.
    Citations: 21     Fields:    Translation:Animals
  79. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15; 87:427-43. PMID: 24055554.
    Citations: 12     Fields:    Translation:Humans
  80. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct; 10(5):056017. PMID: 24018288.
    Citations: 25     Fields:    Translation:AnimalsCells
  81. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol. 2013 Aug; 26(4):414-9. PMID: 23820102.
    Citations: 22     Fields:    Translation:HumansAnimals
  82. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187; PMCID: PMC3754454.
    Citations: 54     Fields:    Translation:Humans
  83. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41. PMID: 23891828.
    Citations: 17     Fields:    Translation:Humans
  84. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of a rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 03; 33(27):11070-5. PMID: 23825412.
    Citations: 64     Fields:    Translation:Humans
  85. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1142-51. PMID: 23487781.
    Citations: 249     Fields:    Translation:HumansCTClinical Trials
  86. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. Int IEEE EMBS Conf Neural Eng. 2013; 1104-1107. PMID: 25284633.
    Citations: 1     
  87. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:5426-9. PMID: 24110963.
    Citations: 3     Fields:    Translation:Humans
  88. Prerau MJ, Purdon PL, Eden UT. Tracking non-stationary spectral peak structure in EEG data. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:417-20. PMID: 24109712.
    Citations: 3     Fields:    Translation:Humans
  89. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86. PMID: 23129622.
    Citations: 163     Fields:    Translation:Humans
  90. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3095-100. PMID: 22323592.
    Citations: 115     Fields:    Translation:Humans
  91. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol. 2012; 3:4. PMID: 22375120.
    Citations: 4     
  92. Pirondini E, Babadi B, Lamus C, Brown EN, Purdon PL. A spatially-regularized dynamic source localization algorithm for EEG. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:6752-5. PMID: 23367479.
    Citations:    Fields:    Translation:Humans
  93. Sampson AL, Babadi B, Prerau MJ, Mukamel EA, Brown EN, Purdon PL. Beamforming approach to phase-amplitude modulation analysis of multi-channel EEG. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:6731-4. PMID: 23367474.
    Citations: 1     Fields:    Translation:Humans
  94. Obregon-Henao G, Babadi B, Lamus C, Brown EN, Purdon PL. A fast iterative greedy algorithm for MEG source localization. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:6748-51. PMID: 23367478.
    Citations: 3     Fields:    Translation:Humans
  95. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:3124-7. PMID: 23366587.
    Citations: 3     Fields:    Translation:Humans
  96. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 01; 63(2):894-909. PMID: 22155043.
    Citations: 13     Fields:    Translation:Humans
  97. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 01; 5(2B):1207-1228. PMID: 22081780.
    Citations: 11     
  98. Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8832-7. PMID: 21555565.
    Citations: 104     Fields:    Translation:Humans
  99. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4705-8. PMID: 22255388.
    Citations: 6     Fields:    Translation:Humans
  100. Chen Z, Citi L, Purdon PL, Brown EN, Barbieri R. Instantaneous assessment of autonomic cardiovascular control during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:8444-7. PMID: 22256307.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  101. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011; 34:601-28. PMID: 21513454.
    Citations: 192     Fields:    Translation:HumansAnimals
  102. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1981-4. PMID: 22254722.
    Citations: 18     Fields:    Translation:Humans
  103. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4725-8. PMID: 22255393.
    Citations: 3     Fields:    Translation:Humans
  104. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22665-70. PMID: 21149695.
    Citations: 155     Fields:    Translation:HumansCells
  105. Chen Z, Purdon PL, Harrell G, Pierce ET, Walsh J, Brown EN, Barbieri R. Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method. Ann Biomed Eng. 2011 Jan; 39(1):260-76. PMID: 20945159.
    Citations: 12     Fields:    Translation:Humans
  106. Chen Z, Purdon PL, Brown EN, Barbieri R. A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:3567-70. PMID: 21096829.
    Citations: 4     Fields:    Translation:Humans
  107. Napadow V, Dhond R, Park K, Kim J, Makris N, Kwong KK, Harris RE, Purdon PL, Kettner N, Hui KK. Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture. Neuroimage. 2009 Aug 01; 47(1):289-301. PMID: 19345268.
    Citations: 43     Fields:    Translation:Humans
  108. Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci. 2009 Mar; 1157:61-70. PMID: 19351356.
    Citations: 29     Fields:    Translation:Humans
  109. Chen Z, Purdon PL, Pierce ET, Harrell G, Walsh J, Salazar AF, Tavares CL, Brown EN, Barbieri R. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:5336-9. PMID: 19963899.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  110. Purdon PL, Millan H, Fuller PL, Bonmassar G. An open-source hardware and software system for acquisition and real-time processing of electrophysiology during high field MRI. J Neurosci Methods. 2008 Nov 15; 175(2):165-86. PMID: 18761038.
    Citations: 6     Fields:    Translation:Humans
  111. Lamus C, Long CJ, Hämäläinen MS, Brown EN, Purdon PL. PARAMETER ESTIMATION AND DYNAMIC SOURCE LOCALIZATION FOR THE MAGNETOENCEPHALOGRAPHY (MEG) INVERSE PROBLEM. Proc IEEE Int Symp Biomed Imaging. 2007 May 15; 2007:1092-1095. PMID: 20407591.
    Citations: 6     
  112. Vasios CE, Angelone LM, Purdon PL, Ahveninen J, Belliveau JW, Bonmassar G. EEG/(f)MRI measurements at 7 Tesla using a new EEG cap ("InkCap"). Neuroimage. 2006 Dec; 33(4):1082-92. PMID: 17035045.
    Citations: 19     Fields:    Translation:Humans
  113. Zhang WT, Mainero C, Kumar A, Wiggins CJ, Benner T, Purdon PL, Bolar DS, Kwong KK, Sorensen AG. Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gating. Neuroimage. 2006 Jul 15; 31(4):1506-12. PMID: 16624588.
    Citations: 15     Fields:    Translation:Humans
  114. Angelone LM, Vasios CE, Wiggins G, Purdon PL, Bonmassar G. On the effect of resistive EEG electrodes and leads during 7 T MRI: simulation and temperature measurement studies. Magn Reson Imaging. 2006 Jul; 24(6):801-12. PMID: 16824975.
    Citations: 22     Fields:    Translation:Humans
  115. Napadow V, Dhond RP, Purdon P, Kettner N, Makris N, Kwong KK, Hui KK. Correlating acupuncture FMRI in the human brainstem with heart rate variability. Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:4496-9. PMID: 17281236.
    Citations: 18     Fields:    
  116. Bonmassar G, Purdon PL, Jääskeläinen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage. 2002 Aug; 16(4):1127-41. PMID: 12202099.
    Citations: 39     Fields:    Translation:Humans
  117. Purdon PL, Solo V, Weisskoff RM, Brown EN. Locally regularized spatiotemporal modeling and model comparison for functional MRI. Neuroimage. 2001 Oct; 14(4):912-23. PMID: 11554810.
    Citations: 24     Fields:    Translation:Humans
  118. Solo V, Purdon P, Weisskoff R, Brown E. A signal estimation approach to functional MRI. IEEE Trans Med Imaging. 2001 Jan; 20(1):26-35. PMID: 11293689.
    Citations: 4     Fields:    Translation:Humans
  119. Purdon PL, Weisskoff RM. Effect of temporal autocorrelation due to physiological noise and stimulus paradigm on voxel-level false-positive rates in fMRI. Hum Brain Mapp. 1998; 6(4):239-49. PMID: 9704263.
    Citations: 91     Fields:    Translation:Humans
  120. Hausdorff JM, Purdon PL, Peng CK, Ladin Z, Wei JY, Goldberger AL. Fractal dynamics of human gait: stability of long-range correlations in stride interval fluctuations. J Appl Physiol (1985). 1996 May; 80(5):1448-57. PMID: 8727526.
    Citations: 146     Fields:    Translation:Humans
  121. Cowan ME, Purdon PL. A study of the "paraffin test". J Forensic Sci. 1967 Jan; 12(1):19-36. PMID: 6029449.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.