Sai Chun Tang, PH.D.
|Title||Assistant Professor of Radiology|
|Institution||Brigham and Women's Hospital|
|Address||Brigham and Women's Hospital|
Radiology, EBRC 518
221 Longwood Ave
Boston MA 02115
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|1996||Li Po Chun Scholarships|
|1997||First prize of IEEE HK Section Student Paper Contest|
|1997||Interek Testing Service (ITS) Scholarship|
|2000||Champion of Paper Contest (IEE Hong Kong Younger Member Section)|
|2002||Award for the Best Poster Presentation in the 16th European Conference on Solid-State Transducers |
|2011||IEEE Senior Member|
|2013||Best Poster Award in the 2013 Massachusetts Biotechnology Council Annual Meeting|
|2013||First Prize for Poster Presentation in the 1st Annual BWH Radiology Research Symposium|
|2015||Brigham and Women’s Hospital Faculty Career Development Awards|
I have been conducting research in medical electronics for 10 years after obtaining my postdoctoral training at MIT and the National University of Ireland, Galway, and my PhD in Electronic Engineering at the City University of Hong Kong. I joined the Brigham and Women's Hospital, and Harvard Medical School in 2004. Presently, I am an Assistant Professor of Radiology at the Harvard Medical School.
My PhD research centered on contactless energy transfer by magnetic coupling. After joining the Harvard Medical School, I applied this technique to medical research and proposed a method to wirelessly transmit energy to operate a deep-seated implantable ultrasonic device without the requirement of embedded battery. After I presented this study in a conference, a company subcontracted an NIH SBIR project to us for the development of a wirelessly powered implantable blood flow monitoring device.
In my research on Wireless Intermediate-range Scheme for Energy and Signal Transmission (WISEST) for implantable medical devices, I suggested a patent-pending coil segmentation method that can significantly reduce the transmitting coil voltage to a safe level (~10V) while the commonly used methods require more than a few kilo-volt. The implanted device can be deep-seated or even locomotive in the body and the energy receiving coils do not require ferromagnetic cores, so MRI compatible implants are achievable. My wireless energy transmission research resulted in two first prizes in the MassBio Annual Meeting and BWH Radiology Research Symposium in 2013.
In the Focused Ultrasound Lab at BWH, I have developed novel excitation methods for high-intensity focused ultrasound (HIFU) transducer for non-invasive treatments, including tumor ablation, stroke therapy, and local opening of the blood brain barrier. In 2014, I was involved in the design and development of a 2000-channel ultrasound power amplifier system for the excitation of large-scale phased array transducers, which has been used in the Sunnybrook Health Sciences Centre in Toronto. In 2007, I suggested a novel technique for HIFU amplifier design using a harmonic cancellation scheme that substantially reduce the size and cost of the amplifier system by eliminating the output filter. Meanwhile, I was involved in the design and investigation of a robotic-arm-controlled non-invasive HIFU surgical system, initially for instant blood vessel clogging. The amplifier system I worked on can generate a high-frequency voltage to drive ultrasound transducers up to 10-MHz in order to improve the spatial resolution of the HIFU focusing.
In addition to therapeutic ultrasound, I have also developed diagnostic transcranial ultrasound systems, including a computer-controlled system and a portable microcontroller-based system, for sinus infection detection. The portable system was used in clinical trials at the Boston Medical Center. Presently, I am developing a large scale ultrasound tomographic brain imaging system.
In summary, my research in medical electronics results in several peer-reviewed journal publications. The ultrasound systems I developed have been tested in clinical trials. The wireless energy transmission method resulted in a patent application, two first prizes in poster presentations, and an NIH SBIR subcontract. Going forward, I am working on applying this technique to more novel clinical devices.
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