Harvard Catalyst Profiles

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Zsuzsanna Kinga Zsengeller, M.D., Ph.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. 2025 Peter Joseph Pappas Research Grant Award (ZSENGELLER, ZSUZSANNA KINGA) Jan 1, 2025 - Jan 31, 2026
    Preeclampsia Foundation
    Novel small molecule therapeutics for the treatment of preeclampsia
    Role: PRINCIPAL INVESTIGATOR
  2. R21HD115117 (ZSENGELLER, ZSUZSANNA KINGA) Aug 15, 2024 - Jul 31, 2026
    NIH
    Restoration of reduced nitric oxide bioavailability in Preeclampsia
    Role: Principal Investigator
  3. Innovate2024-42715 (ZSENGELLER, ZSUZSANNA KINGA) Jul 1, 2024 - Jun 30, 2026
    MLSC
    Second generation dual-function redox modulators for preeclampsia therapy
    Role: Principal Investigator
  4. SPARK (ZSENGELLER, ZSUZSANNA KINGA) Jul 1, 2024 - Jun 30, 2025
    BIDMC
    HMP - a nitroxide analogue to taget oxidative stress in Preeclampsia
    Role: Principal Investigator
  5. R15HD110945 (TOROK, MARIANNA) Sep 6, 2023 - Aug 31, 2026
    NIH
    Mitochondria-targeting Novel Cationic Hydrazone Antioxidants for the Treatment of Preeclampsia
    Role: Co-Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 87 total Publications Show all
  1. Ortega-Ribera M, Zhuang Y, Babuta M, Brezani V, Joshi RS, Zsengeller Z, Thevkar Nagesh P, Wang Y, Bronson R, Szabo G. A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition. Cell Mol Gastroenterol Hepatol. 2024 Dec 20; 101446. PMID: 39710168.
    Citations:
    Fields: GasGastroenterology
  2. Costa M, Adhamidhi F, Mastyugin M, Fusco AR, Lazarev A, Zsengeller ZK, Török M, Török B. Solvent- and Catalyst-Free Environmentally Benign High Hydrostatic Pressure-Assisted Synthesis of Bioactive Hydrazones and the Evaluation of Their Stability Under Various Storage Conditions. Molecules. 2024 Nov 08; 29(22). PMID: 39598676; PMCID: PMC11596250.
    Citations:
    Fields: BioBiologyTranslation:AnimalsCells
  3. Sula Karreci E, Jacas S, Donovan O, Pintye D, Wiley N, Zsengeller ZK, Schlondorff J, Alper SL, Friedman DJ, Pollak MR. Differing sensitivities to angiotensin converting enzyme inhibition of kidney disease mediated by APOL1 high-risk variants G1 and G2. Kidney Int. 2024 Dec; 106(6):1072-1085. PMID: 39181397; PMCID: PMC11585418.
    Citations:
    Fields: NepNephrologyTranslation:HumansAnimals
  4. Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM. Hepatocyte nuclear factor 4a mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury. Kidney Int. 2023 12; 104(6):1150-1163. PMID: 37783445; PMCID: PMC10843022.
    Citations: 3
    Fields: NepNephrologyTranslation:Animals
  5. Pintye D, Sziva RE, Mastyugin M, Young BC, Jacas S, Török M, Salahuddin S, Jagtap P, Southan GJ, Zsengellér ZK. A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia-Relevance for Preeclampsia Therapy. Biology (Basel). 2023 Sep 12; 12(9). PMID: 37759628; PMCID: PMC10525611.
    Citations: 2
  6. Pintye D, Sziva RE, Mastyugin M, Török M, Jacas S, Lo A, Salahuddin S, Zsengellér ZK. Nitroxide-HMP-Protects Human Trophoblast HTR-8/SVneo Cells from H2O2-Induced Oxidative Stress by Reducing the HIF1A Signaling Pathway. Antioxidants (Basel). 2023 Aug 08; 12(8). PMID: 37627573; PMCID: PMC10451835.
    Citations: 3
  7. Biwer LA, Lu Q, Ibarrola J, Stepanian A, Man JJ, Carvajal BV, Camarda ND, Zsengeller Z, Skurnik G, Seely EW, Karumanchi SA, Jaffe IZ. Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia. Circ Res. 2023 03 17; 132(6):674-689. PMID: 36815487; PMCID: PMC10119809.
    Citations: 5
    Fields: CarCardiologyVasVascular DiseasesTranslation:HumansAnimals
  8. McCarthy GM, Blasio A, Donovan OG, Schaller LB, Bock-Hughes A, Magraner JM, Suh JH, Tattersfield CF, Stillman IE, Shah SS, Zsengeller ZK, Subramanian B, Friedman DJ, Pollak MR. Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 08 01; 14(8). PMID: 34350953; PMCID: PMC8353097.
    Citations: 22
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  9. Valvo V, Iesato A, Kavanagh TR, Priolo C, Zsengeller Z, Pontecorvi A, Stillman IE, Burke SD, Liu X, Nucera C. Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma. Thyroid. 2021 09; 31(9):1335-1358. PMID: 33107403; PMCID: PMC8558082.
    Citations: 13
    Fields: EndEndocrinologyTranslation:HumansAnimalsCells
  10. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. TFEB-driven lysosomal biogenesis is pivotal for PGC1?a??-dependent renal stress resistance. JCI Insight. 2020 08 06; 5(15). PMID: 32759500; PMCID: PMC7455057.
    Citations: 3
    Fields: MedMedicine (General)
  11. Burke SD, Zsengellér ZK, Karumanchi SA, Shainker SA. A mouse model of placenta accreta spectrum. Placenta. 2020 09 15; 99:8-15. PMID: 32716845.
    Citations: 2
    Fields: EmbEmbryologyObsObstetricsPhyPhysiologyTranslation:AnimalsCells
  12. Lecarpentier E, Zsengellér ZK, Salahuddin S, Covarrubias AE, Lo A, Haddad B, Thadhani RI, Karumanchi SA. Total Versus Free Placental Growth Factor Levels in the Pathogenesis of Preeclampsia. Hypertension. 2020 09; 76(3):875-883. PMID: 32654553.
    Citations: 11
    Fields: VasVascular DiseasesTranslation:Humans
  13. Zsengellér ZK, Gerard NP. The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling. Immunobiology. 2020 03; 225(2):151895. PMID: 31843260.
    Citations: 3
    Fields: AllAllergy and ImmunologyTranslation:HumansAnimalsCells
  14. Zsengellér ZK, Lo A, Tavasoli M, Pernicone E, Karumanchi SA, Rosen S. Soluble fms-Like Tyrosine Kinase 1 Localization in Renal Biopsies of CKD. Kidney Int Rep. 2019 Dec; 4(12):1735-1741. PMID: 31844810; PMCID: PMC6895657.
    Citations: 3
  15. Yonekura Collier AR, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA. Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia. Hypertens Pregnancy. 2019 Aug; 38(3):193-199. PMID: 31291799; PMCID: PMC6707710.
    Citations: 24
    Fields: ObsObstetricsVasVascular DiseasesTranslation:HumansCells
  16. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance. JCI Insight. 2019 03 14; 5. PMID: 30870143; PMCID: PMC6538327.
    Citations: 37
    Fields: MedMedicine (General)Translation:AnimalsCells
  17. Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho BMDC, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A. RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nat Biotechnol. 2018 Nov 19. PMID: 30451990; PMCID: PMC6526074.
    Citations: 66
    Fields: BioBiotechnology
  18. Covarrubias AE, Lecarpentier E, Lo A, Salahuddin S, Gray KJ, Karumanchi SA, Zsengellér ZK. AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis. Am J Pathol. 2019 01; 189(1):104-114. PMID: 30315766; PMCID: PMC6854435.
    Citations: 32
    Fields: PatPathologyTranslation:HumansCells
  19. Varga ZV, Erdelyi K, Paloczi J, Cinar R, Zsengeller ZK, Jourdan T, Matyas C, Nemeth BT, Guillot A, Xiang X, Mehal A, Haskó G, Stillman IE, Rosen S, Gao B, Kunos G, Pacher P. Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice. Hepatology. 2018 10; 68(4):1519-1533. PMID: 29631342.
    Citations: 24
    Fields: GasGastroenterologyTranslation:HumansAnimals
  20. Sircar M, Rosales IA, Selig MK, Xu D, Zsengeller ZK, Stillman IE, Libermann TA, Karumanchi SA, Thadhani RI. Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease. Am J Pathol. 2018 10; 188(10):2147-2154. PMID: 30253844; PMCID: PMC6180251.
    Citations: 26
    Fields: PatPathologyTranslation:HumansCells
  21. Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM. Renal PGC1a May Be Associated with Recovery after Delayed Graft Function. Nephron. 2018; 138(4):303-309. PMID: 29268263; PMCID: PMC5858968.
    Citations: 8
    Fields: NepNephrologyTranslation:HumansCells
  22. Hecht JL, Ordi J, Carrilho C, Ismail MR, Zsengeller ZK, Karumanchi SA, Rosen S. The pathology of eclampsia: An autopsy series. Hypertens Pregnancy. 2017 Aug; 36(3):259-268. PMID: 28678644.
    Citations: 14
    Fields: ObsObstetricsVasVascular DiseasesTranslation:Humans
  23. Shainker SA, Dannheim K, Gerson KD, Neo D, Zsengeller ZK, Pernicone E, Karumanchi SA, Hacker MR, Hecht JL. Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation. Arch Gynecol Obstet. 2017 Aug; 296(2):257-262. PMID: 28631072.
    Citations: 7
    Fields: GynGynecologyObsObstetricsTranslation:HumansCells
  24. Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZ, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T, Hozawa A, Karumanchi SA, Suzuki N, Yamamoto M. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Sci Signal. 2017 May 16; 10(479). PMID: 28512147.
    Citations: 35
    Fields: CelCell BiologyPhyPhysiologySciScienceTranslation:HumansAnimals
  25. Paauw ND, Joles JA, Spradley FT, Bakrania B, Zsengeller ZK, Franx A, Verhaar MC, Granger JP, Lely AT. Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. Am J Physiol Regul Integr Comp Physiol. 2017 05 01; 312(5):R664-R670. PMID: 28202440; PMCID: PMC5451567.
    Citations: 20
    Fields: PhyPhysiologyTranslation:AnimalsPHPublic Health
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.