Harvard Catalyst Profiles

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Madalena Damasio Costa, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL144510 (HECKBERT, SUSAN R) Aug 10, 2019 - Jul 31, 2023
    Heart Rate Fragmentation: New Biomarker of Atrial Fibrillation Risk
    Role: Co-Principal Investigator
  2. R00AG030677 (COSTA, MADALENA D) Sep 1, 2011 - Aug 31, 2015
    Complexity Loss, Aging and the Dynamics of Frailty
    Role: Principal Investigator
  3. K99AG030677 (COSTA, MADALENA D) Jun 1, 2009 - May 31, 2011
    Complexity Loss, Aging and the Dynamics of Frailty
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Costa MD, Heckbert SR, Redline S, Goldberger AL. Method to quantify the impact of sleep on cardiac neuroautonomic functionality: application to the prediction of cardiovascular events in the Multi-Ethnic Study of Atherosclerosis. Am J Physiol Regul Integr Comp Physiol. 2022 12 01; 323(6):R968-R978. PMID: 36222857; PMCID: PMC9829462.
    Citations:    Fields:    Translation:Humans
  2. Costa MD, Redline S, Hughes TM, Heckbert SR, Goldberger AL. Prediction of Cognitive Decline Using Heart Rate Fragmentation Analysis: The Multi-Ethnic Study of Atherosclerosis. Front Aging Neurosci. 2021; 13:708130. PMID: 34512310; PMCID: PMC8428192.
  3. Costa MD, Redline S, Soliman EZ, Goldberger AL, Heckbert SR. Fragmented sinoatrial dynamics in the prediction of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis. Am J Physiol Heart Circ Physiol. 2021 01 01; 320(1):H256-H271. PMID: 32986961.
    Citations: 2     Fields:    Translation:Humans
  4. Gibson LE, Henriques TS, Costa MD, Davis RB, Mittleman MA, Mathur P, Subramaniam B. Comparison of Invasive and Noninvasive Blood Pressure Measurements for Assessing Signal Complexity and Surgical Risk in Cardiac Surgical Patients. Anesth Analg. 2020 06; 130(6):1653-1660. PMID: 30399022; PMCID: PMC7598931.
    Citations: 4     Fields:    Translation:Humans
  5. Costa MD, Goldberger AL. Heart rate fragmentation: using cardiac pacemaker dynamics to probe the pace of biological aging. Am J Physiol Heart Circ Physiol. 2019 06 01; 316(6):H1341-H1344. PMID: 30951362.
    Citations: 4     Fields:    Translation:HumansAnimals
  6. Costa MD, Redline S, Davis RB, Heckbert SR, Soliman EZ, Goldberger AL. Heart Rate Fragmentation as a Novel Biomarker of Adverse Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis. Front Physiol. 2018; 9:1117. PMID: 30233384.
    Citations: 11     
  7. Geovanini GR, Wang R, Weng J, Tracy R, Jenny NS, Goldberger AL, Costa MD, Liu Y, Libby P, Redline S. Elevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2018 04 15; 257:318-323. PMID: 29506719; PMCID: PMC5842816.
    Citations: 10     Fields:    Translation:HumansCells
  8. Henriques TS, Costa MD, Mathur P, Mathur P, Davis RB, Mittleman MA, Khabbaz KR, Goldberger AL, Subramaniam B. Complexity of preoperative blood pressure dynamics: possible utility in cardiac surgical risk assessment. J Clin Monit Comput. 2019 Feb; 33(1):31-38. PMID: 29564751; PMCID: PMC6150848.
    Citations: 8     Fields:    Translation:Humans
  9. Costa MD, Davis RB, Goldberger AL. Heart Rate Fragmentation: A Symbolic Dynamical Approach. Front Physiol. 2017; 8:827. PMID: 29184505; PMCID: PMC5694498.
    Citations: 15     
  10. Costa MD, Davis RB, Goldberger AL. Heart Rate Fragmentation: A New Approach to the Analysis of Cardiac Interbeat Interval Dynamics. Front Physiol. 2017; 8:255. PMID: 28536533; PMCID: PMC5422439.
    Citations: 29     
  11. Burykin A, Mariani S, Henriques T, Silva TF, Schnettler WT, Costa MD, Goldberger AL. Remembrance of time series past: simple chromatic method for visualizing trends in biomedical signals. Physiol Meas. 2015 Jul; 36(7):N95-102. PMID: 26012777.
    Citations: 1     Fields:    
  12. Costa MD, Goldberger AL. Response to "Comment on 'Dynamical glucometry: Use of multiscale entropy analysis in diabetes'" [Chaos 25, 058101 (2015)]. Chaos. 2015 May; 25(5):058102. PMID: 26026329.
    Citations:    Fields:    Translation:Humans
  13. Costa MD, Goldberger AL. Generalized Multiscale Entropy Analysis: Application to Quantifying the Complex Volatility of Human Heartbeat Time Series. Entropy (Basel). 2015 Mar; 17(3):1197-1203. PMID: 27099455; PMCID: PMC4834981.
    Citations: 28     
  14. Wayne PM, Gow BJ, Costa MD, Peng CK, Lipsitz LA, Hausdorff JM, Davis RB, Walsh JN, Lough M, Novak V, Yeh GY, Ahn AC, Macklin EA, Manor B. Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies. PLoS One. 2014; 9(12):e114731. PMID: 25494333; PMCID: PMC4262457.
    Citations: 28     Fields:    Translation:Humans
  15. Costa MD, Henriques T, Munshi MN, Segal AR, Goldberger AL. Dynamical glucometry: use of multiscale entropy analysis in diabetes. Chaos. 2014 Sep; 24(3):033139. PMID: 25273219.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  16. Wayne PM, Gow BJ, Costa MD, Peng CK, Hausdorff JM, Lipsitz LA, Davis RB, Novak V, Manor B. Do complexity-based measures of sway inform long- and short-term effects of tai chi training on balance in healthy adults? J Altern Complement Med. 2014 May; 20(5):A25. PMID: 24805551.
  17. Henriques T, Munshi MN, Segal AR, Costa MD, Goldberger AL. "Glucose-at-a-Glance": New Method to Visualize the Dynamics of Continuous Glucose Monitoring Data. J Diabetes Sci Technol. 2014 Mar; 8(2):299-306. PMID: 24876582.
    Citations: 8     Fields:    
  18. Subramaniam B, Khabbaz KR, Heldt T, Lerner AB, Mittleman MA, Davis RB, Goldberger AL, Costa MD. Blood pressure variability: can nonlinear dynamics enhance risk assessment during cardiovascular surgery? J Cardiothorac Vasc Anesth. 2014 Apr; 28(2):392-7. PMID: 24508020.
    Citations: 11     Fields:    Translation:Humans
  19. Costa MD, Schnettler WT, Amorim-Costa C, Bernardes J, Costa A, Goldberger AL, Ayres-de-Campos D. Complexity-loss in fetal heart rate dynamics during labor as a potential biomarker of acidemia. Early Hum Dev. 2014 Jan; 90(1):67-71. PMID: 24290526.
    Citations: 10     Fields:    Translation:Humans
  20. Cui X, Peng CK, Costa MD, Weiss A, Goldberger AL, Hausdorff JM. Development of a new approach to quantifying stepping stability using ensemble empirical mode decomposition. Gait Posture. 2014; 39(1):495-500. PMID: 24095265.
    Citations: 7     Fields:    Translation:Humans
  21. Stirling LA, Lipsitz LA, Qureshi M, Kelty-Stephen DG, Goldberger AL, Costa MD. Use of a tracing task to assess visuomotor performance: effects of age, sex, and handedness. J Gerontol A Biol Sci Med Sci. 2013 Aug; 68(8):938-45. PMID: 23388876; PMCID: PMC3712360.
    Citations: 4     Fields:    Translation:Humans
  22. Lim AS, Yu L, Costa MD, Leurgans SE, Buchman AS, Bennett DA, Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. Sleep. 2012 May 01; 35(5):633-40B. PMID: 22547889.
    Citations: 36     Fields:    Translation:Humans
  23. Lim AS, Yu L, Costa MD, Buchman AS, Bennett DA, Leurgans SE, Saper CB. Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis. Sleep. 2011 Nov 01; 34(11):1569-81. PMID: 22043128.
    Citations: 31     Fields:    Translation:Humans
  24. Manor B, Costa MD, Hu K, Newton E, Starobinets O, Kang HG, Peng CK, Novak V, Lipsitz LA. Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol (1985). 2010 Dec; 109(6):1786-91. PMID: 20947715.
    Citations: 91     Fields:    Translation:Humans
  25. Kang HG, Costa MD, Priplata AA, Starobinets OV, Goldberger AL, Peng CK, Kiely DK, Cupples LA, Lipsitz LA. Frailty and the degradation of complex balance dynamics during a dual-task protocol. J Gerontol A Biol Sci Med Sci. 2009 Dec; 64(12):1304-11. PMID: 19679739; PMCID: PMC2781784.
    Citations: 55     Fields:    Translation:Humans
  26. Costa M, Ghiran I, Peng CK, Nicholson-Weller A, Goldberger AL. Complex dynamics of human red blood cell flickering: alterations with in vivo aging. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Aug; 78(2 Pt 1):020901. PMID: 18850779.
    Citations: 26     Fields:    Translation:HumansCells
  27. Costa MD, Peng CK, Goldberger AL. Multiscale analysis of heart rate dynamics: entropy and time irreversibility measures. Cardiovasc Eng. 2008 Jun; 8(2):88-93. PMID: 18172763.
    Citations: 54     Fields:    
  28. Costa M, Goldberger AL, Peng CK. Broken asymmetry of the human heartbeat: loss of time irreversibility in aging and disease. Phys Rev Lett. 2005 Nov 04; 95(19):198102. PMID: 16384029.
    Citations: 38     Fields:    Translation:Humans
  29. Costa M, Goldberger AL, Peng CK. Multiscale entropy analysis of biological signals. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Feb; 71(2 Pt 1):021906. PMID: 15783351.
    Citations: 459     Fields:    Translation:HumansCTClinical Trials
  30. Costa M, Moody GB, Henry I, Goldberger AL. PhysioNet: an NIH research resource for complex signals. J Electrocardiol. 2003; 36 Suppl:139-44. PMID: 14716615.
    Citations: 7     Fields:    Translation:Humans
  31. Costa M, Goldberger AL, Peng CK. Multiscale entropy analysis of complex physiologic time series. Phys Rev Lett. 2002 Aug 05; 89(6):068102. PMID: 12190613.
    Citations: 528     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.