Harvard Catalyst Profiles

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Michael A. Gimbrone Jr., M.D.

Title
Institution
Department
Address
Phone

Mentoring
Differential Effects of Biomechanical Forces on Chromatin Remodeling
Summer, 05/22/00 - 08/18/00
Exploring Gene Expression Profiles of Endothelial Cells Exposed to District Hemodynamic Environments in the Mouse Aorta
Part Time/Continuation, 09/15/00 - 05/15/01
Exploring Gene Expression Profiles of Endothelial Cells Exposed to Distinct Hemodynamic Environments in the Mouse Aorta
Summer, 06/18/00 - 08/31/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG032443 (GIMBRONE, MICHAEL A) Sep 1, 2010 - May 31, 2015
    NIH/NIA
    PROGERIN ENDOTHELIAL DYSFUNCTION AND VASCULAR DISEASE
    Role: Principal Investigator
  2. P50HL056985 (GIMBRONE, MICHAEL A) Apr 1, 1998 - Mar 31, 2008
    NIH/NHLBI
    CRITICAL TRANSITIONS IN ATHEROGENESIS
    Role: Principal Investigator
  3. P01HL048743 (MICHEL, THOMAS) Sep 2, 1997 - Sep 29, 1999
    NIH/NHLBI
    Arterial Dysfunction: Basic and Clinical Mechanisms
    Role: Co-Principal Investigator
  4. R37HL051150 (GIMBRONE, MICHAEL A) Jul 15, 1994 - May 31, 2005
    NIH/NHLBI
    ENDOTHELIAL GENE REGULATION BY BIOMECHANICAL FORCES
    Role: Principal Investigator
  5. R01HL051150 (GIMBRONE, MICHAEL A) Jul 15, 1994 - May 31, 1999
    NIH/NHLBI
    ENDOTHELIAL GENE REGULATION BY BIOMECHANICAL FORCES
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gimbrone MA, García-Cardeña G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016 Feb 19; 118(4):620-36. PMID: 26892962.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  2. Gimbrone MA, García-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol. 2013 Jan-Feb; 22(1):9-15. PMID: 22818581.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  3. Gimbrone MA. The Gordon Wilson lecture. Understanding vascular endothelium: a pilgrim's progress. Endothelial dysfunction, biomechanical forces and the pathobiology of atherosclerosis. Trans Am Clin Climatol Assoc. 2010; 121:115-27; discussion 127. PMID: 20697555.
    Citations: 6     Fields:    Translation:HumansAnimals
  4. Nathan DG, Gimbrone MA. Judah Folkman, MD, 1933-2008. Pharos Alpha Omega Alpha Honor Med Soc. 2009; 4-8. PMID: 19263646.
    Citations:    Fields:    Translation:Humans
  5. Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res. 2007 Sep 28; 101(7):723-33. PMID: 17673673.
    Citations: 64     Fields:    Translation:HumansCells
  6. García-Cardeña G, Gimbrone MA. Biomechanical modulation of endothelial phenotype: implications for health and disease. Handb Exp Pharmacol. 2006; (176 Pt 2):79-95. PMID: 16999225.
    Citations: 17     Fields:    Translation:HumansAnimals
  7. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA, García-Cardeña G. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest. 2006 Jan; 116(1):49-58. PMID: 16341264.
    Citations: 197     Fields:    Translation:HumansCells
  8. Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA, García-Cardeña G. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005 Jul 22; 280(29):26714-9. PMID: 15878865.
    Citations: 64     Fields:    Translation:Humans
  9. Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA, Balasubramanian V, García-Cardeña G, Jain MK. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005 Mar 18; 96(5):e48-57. PMID: 15718498.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  10. Gimbrone MA Jr. . Hemodynamic forces as modulators of endothelial gene expression in health and disease. Foundation IPSEN Colloquium, Life and Death of the Vascular Tree, Paris. 2005.
  11. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14871-6. PMID: 15466704.
    Citations: 167     Fields:    Translation:Humans
  12. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15. PMID: 15136591.
    Citations: 182     Fields:    Translation:HumansCells
  13. Comander J, Natarajan S, Gimbrone MA, García-Cardeña G. Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation. BMC Genomics. 2004 Feb 27; 5(1):17. PMID: 15113402.
    Citations: 10     Fields:    Translation:Cells
  14. Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, Gimbrone MA, Ertl G, Huang PL. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol. 2004 May; 286(5):C1195-202. PMID: 15075219.
    Citations: 35     Fields:    Translation:AnimalsCells
  15. Kwei S, Stavrakis G, Takahas M, Taylor G, Folkman MJ, Gimbrone MA, García-Cardeña G. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol. 2004 Jan; 164(1):81-9. PMID: 14695322.
    Citations: 23     Fields:    Translation:Animals
  16. Lin ZY, Senbanerjee S, Kumar A, Vaughan DE, Parmar K, Gimbrone MA, Garcia-Cardena G, Jain MK. The Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic gene expression . Scientific Session 2004 American Heart Assoc., New Orleans, LA. Circulation . 2004; 110:317 .
  17. Gimbrone MA Jr, Garcia-Cardena G, Dai G, Comander J, Ou Y, Ku I, Anderson K. Endothelial phenotypes in health and disease: Genomic approaches. XVth International Symposium on "Drugs Affecting Lipid Metabolism", Venice. 2004.
  18. Kiely JM, Hu Y, García-Cardeña G, Gimbrone MA. Lipid raft localization of cell surface E-selectin is required for ligation-induced activation of phospholipase C gamma. J Immunol. 2003 Sep 15; 171(6):3216-24. PMID: 12960351.
    Citations: 21     Fields:    Translation:HumansCells
  19. Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601. PMID: 12707043.
    Citations: 57     Fields:    Translation:AnimalsCells
  20. Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003 Apr 01; 167(7):1027-35. PMID: 12663342.
    Citations: 180     Fields:    Translation:HumansAnimals
  21. Kwei S, Takahas M, Taylor G, Folkman J, Gimbrone MA Jr, Garcia-Cardena G. A novel mouse model of venous arterialization. Experimental Biology 2003, San Diego. 2003.
  22. MA Gimbrone Jr, G Garcia-Cardena, J Comander, B Blackman, G Dai, K Anderson. Biochemical and Biomechanical Paradigms of Endothelial Activation in Health and Disease. XIIIth Int. Symposium on Atherosclerosis, Kyoto, Japan. 2003.
  23. Hu Y, Kiely J-M, Gimbrone MA Jr. E-selectin mediates endothelial survival during inflammation. Experimental Biology 2003, San Diego. 2003; A799.
  24. SenBanerjee S, Lin Z, Atkins B, Greif DM, Rao RM, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Garcia-Cardena G, Gimbrone MA Jr, Jain MK . KLF2 as a novel regulator of endothelial cell function . AHA Scientific Sessions, Orlando. 2003.
  25. I Ku, G Garcia-Cardena, MA Gimbrone Jr. Characterizing Endothelial Genes Expressed in Atherosclerosis-prone and Atherosclerosis-protected Regions of the Mouse Aorta. American Heart Association, Orlando, FL. 2003.
  26. Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54. PMID: 12215436.
    Citations: 73     Fields:    Translation:HumansCells
  27. Blackman BR, García-Cardeña G, Gimbrone MA. A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng. 2002 Aug; 124(4):397-407. PMID: 12188206.
    Citations: 53     Fields:    Translation:HumansCells
  28. Ochi H, Masuda J, Gimbrone MA. Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity. Eur J Immunol. 2002 Jul; 32(7):1821-31. PMID: 12115600.
    Citations: 8     Fields:    Translation:Cells
  29. Meiler SE, Hung RR, Gerszten RE, Gianetti J, Li L, Matsui T, Gimbrone MA, Rosenzweig A. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J Mol Cell Cardiol. 2002 Mar; 34(3):349-59. PMID: 11945026.
    Citations: 6     Fields:    Translation:HumansCells
  30. Garcia-Cardena G, Kwei S, Blackman BR, Fan R, Farnebo F, Gimbrone MA Jr. Molecular description and hemodynamic determinants of venous arterialization. Experimental Biology 2002, New Orleans. FASEB J. 2002; 16:A216.
  31. Yenya Hu, Jeanne-Marie Kiely, Michael A. Gimbrone. E-Selectin Supports Endothelial Survival During Inflammation. American Heart Association, Chicago. 2002.
  32. Ou Y, Garcia-Cardena G, Gimbrone MA Jr. Modulation of nuclear function by biomechanical forces in vascular endothelium. Experimental Biology 2002, New Orleans. FASEB J. 2002; 16:A200.
  33. García-Cardeña G, Comander JI, Blackman BR, Anderson KR, Gimbrone MA. Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis? Ann N Y Acad Sci. 2001 Dec; 947:1-6. PMID: 11795257.
    Citations: 16     Fields:    Translation:Cells
  34. Hu Y, Szente B, Kiely JM, Gimbrone MA. Molecular events in transmembrane signaling via E-selectin. SHP2 association, adaptor protein complex formation and ERK1/2 activation. J Biol Chem. 2001 Dec 21; 276(51):48549-53. PMID: 11602579.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. Comander J, Weber GM, Gimbrone MA, García-Cardeña G. Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res. 2001 Sep; 11(9):1603-10. PMID: 11544205.
    Citations: 5     Fields:    
  36. Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA, Yasukochi Y, Numano F. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1165-71. PMID: 11451746.
    Citations: 30     Fields:    Translation:HumansCells
  37. Schoen FJ, Gimbrone MA. Ramzi S. Cotran, M.D., 1932-2000. Cardiovasc Pathol. 2001 May-Jun; 10(3):107-8. PMID: 11485853.
    Citations: 1     Fields:    
  38. Garcia-Cardeña G, Comander J, Anderson KR, Blackman BR, Gimbrone MA. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4478-85. PMID: 11296290.
    Citations: 117     Fields:    Translation:HumansCells
  39. G Garcia-Cardena, JI Comander, KR Anderson, MA Gimbrone Jr. Defining the Phenotypic Plasticity of Vascular Endothelium. The 6th Saratoga Int. Conference on Atherosclerosis, Tokyo, Japan. 2001.
  40. MA Gimbrone Jr, G Garcia-Cardena, B Blackman, K Anderson. Vascular Endothelium in Health and Disease: Strategies for Analysis of its Functional and Dysfunctional Phenotypes. The 6th Saratoga Int. Conference on Atherosclerosis, Tokyo, Japan. 2001.
  41. Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA, Anderson DJ. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 2001 Feb 15; 230(2):139-50. PMID: 11161568.
    Citations: 68     Fields:    Translation:Animals
  42. Takayama K, Garcia-Cardena G, Comander J, Gimbrone MA Jr, Libby P. Unveiling anti-inflammatory circuitry in human macrophages by transcriptional profiling. Circulation. 2001; 104 (Suppl. S):1531.
  43. Garcia-Cardena G, Comander JI, Anderson KR, Blackman BR, Gimbrone MA Jr. Genomic exploration of the phenotypic plasticity of vascular endothelium exposed to different hemodynamic environments. Arterioscler. Throm. Vasc. Biol. 2001; 21:144.
  44. Blackman BR, Garcia-Cardena G, Gimbrone MA Jr. Frequency modulation of endothelial gene expression by arterial shear stress waveforms. Annual Biomedical Engineering Soc. Meeting, Durham, NC. Annals. Biomed. Eng. 2001; 29(Suppl. 1):S-74.
  45. Ishii H, Yoshida M, Rosenzweig A, Gimbrone MA, Yasukochi Y, Numano F. Adenoviral transduction of human E-selectin into isolated, perfused, rat aortic segments: an ex vivo model for studying leukocyte-endothelial interactions. J Leukoc Biol. 2000 Nov; 68(5):687-92. PMID: 11073108.
    Citations:    Fields:    Translation:HumansAnimalsCells
  46. DiChiara MR, Kiely JM, Gimbrone MA, Lee ME, Perrella MA, Topper JN. Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. J Exp Med. 2000 Sep 04; 192(5):695-704. PMID: 10974035.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. Hu Y, Kiely JM, Szente BE, Rosenzweig A, Gimbrone MA. E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells. J Immunol. 2000 Aug 15; 165(4):2142-8. PMID: 10925300.
    Citations: 16     Fields:    Translation:HumansCells
  48. García-Cardeña G, Anderson KR, Mauri L, Gimbrone MA. Distinct mechanical stimuli differentially regulate the PI3K/Akt survival pathway in endothelial cells. Ann N Y Acad Sci. 2000 May; 902:294-7. PMID: 10865850.
    Citations: 4     Fields:    Translation:HumansCells
  49. Luscinskas FW, Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Rosenzweig A. C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann N Y Acad Sci. 2000 May; 902:288-93. PMID: 10865849.
    Citations: 12     Fields:    Translation:HumansCells