Harvard Catalyst Profiles

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Daniel Alexander Leffler, M.D.

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Research
research activities and funding
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  1. R03DK095937 (LEFFLER, DANIEL ALEXANDER) Jul 1, 2013 - Jun 30, 2015
    NIH
    Validation of Peripheral Microparticles as Novel Biomarkers of Celiac Disease Act
    Role: Principal Investigator
  2. K23DK082619 (LEFFLER, DANIEL ALEXANDER) Aug 1, 2009 - Jul 31, 2014
    NIH
    Non-invasive markers of celiac disease activity during gluten challenge
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Makharia GK, Singh P, Catassi C, Sanders DS, Leffler D, Ali RAR, Bai JC. The global burden of coeliac disease: opportunities and challenges. Nat Rev Gastroenterol Hepatol. 2022 Jan 03. PMID: 34980921.
    Citations:    Fields:    
  2. Therrien A, Leffler DA. Editorial: coeliac disease-it's a family affair. Aliment Pharmacol Ther. 2021 10; 54(7):967-968. PMID: 34506661.
    Citations:    Fields:    Translation:Humans
  3. Pinto-Sanchez MI, Silvester JA, Lebwohl B, Leffler DA, Anderson RP, Therrien A, Kelly CP, Verdu EF. Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease. Nat Rev Gastroenterol Hepatol. 2021 12; 18(12):875-884. PMID: 34526700.
    Citations:    Fields:    Translation:HumansAnimals
  4. Schiepatti A, Rej A, Maimaris S, Cross SS, Porta P, Aziz I, Key T, Goodwin J, Therrien A, Yoosuf S, Leffler DA, Silvester JA, Klersy C, Biagi F, Sanders DS. Clinical classification and long-term outcomes of seronegative coeliac disease: a 20-year multicentre follow-up study. Aliment Pharmacol Ther. 2021 11; 54(10):1278-1289. PMID: 34496060.
    Citations: 1     Fields:    Translation:Humans
  5. Coleman SH, Rej A, Baggus EMR, Lau MS, Marks LJ, Hadjivassiliou M, Cross SS, Leffler DA, Elli L, Sanders DS. What is the Optimal Method Assessing for Persistent Villous Atrophy in Adult Coeliac Disease? J Gastrointestin Liver Dis. 2021 06 18; 30(2):205-212. PMID: 33951123.
    Citations:    Fields:    Translation:Humans
  6. Edwards George JB, Aideyan B, Yates K, Voorhees KN, O'Flynn J, Sweet K, Avery K, Ehrlich A, Bast A, Leffler DA. Gluten-induced Neurocognitive Impairment: Results of a Nationwide Study. J Clin Gastroenterol. 2021 May 28. PMID: 34049371.
    Citations:    Fields:    
  7. Lundin KE, Kelly CP, Sanders DS, Chen K, Kayaniyil S, Wang S, Wani RJ, Barrett C, Yoosuf S, Pettersen ES, Sambrook R, Leffler DA. Understanding celiac disease monitoring patterns and outcomes after diagnosis: A multinational, retrospective chart review study. World J Gastroenterol. 2021 May 28; 27(20):2603-2614. PMID: 34092978.
    Citations:    Fields:    Translation:Humans
  8. Veeraraghavan G, Therrien A, Degroote M, McKeown A, Mitchell PD, Silvester JA, Leffler DA, Leichtner AM, Kelly CP, Weir DC. Non-responsive celiac disease in children on a gluten free diet. World J Gastroenterol. 2021 Apr 07; 27(13):1311-1320. PMID: 33833484.
    Citations:    Fields:    Translation:Humans
  9. Smithson G, Siegelman J, Oki T, Maxwell JR, Leffler DA. The Evolving Landscape of Biomarkers in Celiac Disease: Leading the Way to Clinical Development. Front Immunol. 2021; 12:665756. PMID: 33897715.
    Citations: 1     Fields:    Translation:HumansCells
  10. Kelly CP, Murray JA, Leffler DA, Getts DR, Bledsoe AC, Smithson G, First MR, Morris A, Boyne M, Elhofy A, Wu TT, Podojil JR, Miller SD. TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study. Gastroenterology. 2021 07; 161(1):66-80.e8. PMID: 33722583.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  11. Pultz IS, Hill M, Vitanza JM, Wolf C, Saaby L, Liu T, Winkle P, Leffler DA. Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease. Gastroenterology. 2021 07; 161(1):81-93.e3. PMID: 33741317.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  12. Kivelä L, Caminero A, Leffler DA, Pinto-Sanchez MI, Tye-Din JA, Lindfors K. Current and emerging therapies for coeliac disease. Nat Rev Gastroenterol Hepatol. 2021 03; 18(3):181-195. PMID: 33219355.
    Citations: 7     Fields:    Translation:Humans
  13. Therrien A, Leffler DA. Gluten immunogenic peptides: is knowing half the battle? Am J Clin Nutr. 2020 11 11; 112(5):1147-1148. PMID: 32844173.
    Citations:    Fields:    Translation:Humans
  14. Cappell K, Taylor A, Johnson BH, Gelwicks S, Wang S, Gerber M, Leffler DA. Healthcare Resource Utilization and Costs in Celiac Disease: A US Claims Analysis. Am J Gastroenterol. 2020 11; 115(11):1821-1829. PMID: 33156101.
    Citations: 1     Fields:    Translation:Humans
  15. Leonard MM, Silvester JA, Leffler D, Fasano A, Kelly CP, Lewis SK, Goldsmith JD, Greenblatt E, Kwok WW, McAuliffe WJ, Galinsky K, Siegelman J, Chow IT, Wagner JA, Sapone A, Smithson G. Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial. Gastroenterology. 2021 02; 160(3):720-733.e8. PMID: 33130104.
    Citations: 6     Fields:    Translation:HumansCells
  16. Silvester JA, Comino I, Rigaux LN, Segura V, Green KH, Cebolla A, Weiten D, Dominguez R, Leffler DA, Leon F, Bernstein CN, Graff LA, Kelly CP, Sousa C, Duerksen DR. Exposure sources, amounts and time course of gluten ingestion and excretion in patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2020 11; 52(9):1469-1479. PMID: 32981131.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  17. Cappell K, Taylor A, Johnson BH, Gelwicks S, Wang S, Gerber M, Leffler DA. Healthcare Resource Utilization and Costs in Celiac Disease: A US Claims Analysis. Am J Gastroenterol. 2020 Aug 05. PMID: 32769422.
    Citations:    Fields:    
  18. Therrien A, Silvester JA, Leonard MM, Leffler DA, Fasano A, Kelly CP. Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease. Dig Dis Sci. 2021 06; 66(6):1989-1997. PMID: 32654085.
    Citations:    Fields:    Translation:Humans
  19. Pinto-Sanchez MI, Seiler CL, Santesso N, Alaedini A, Semrad C, Lee AR, Bercik P, Lebwohl B, Leffler DA, Kelly CP, Moayyedi P, Green PH, Verdu EF. Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis. Gastroenterology. 2020 09; 159(3):884-903.e31. PMID: 32416141.
    Citations: 9     Fields:    Translation:HumansAnimals
  20. Freitag TL, Leffler DA. Inside the Mind of a Cereal Killer: New Insights Into the Effect of Celiac Disease on Central Nervous Systems Function. Gastroenterology. 2020 06; 158(8):2043-2045. PMID: 32247693.
    Citations:    Fields:    Translation:HumansAnimals
  21. Clifford S, Taylor AJ, Gerber M, Devine J, Cho M, Walker R, Stefani I, Fidel S, Drahos J, Leffler DA. Concepts and Instruments for Patient-Reported Outcome Assessment in Celiac Disease: Literature Review and Experts' Perspectives. Value Health. 2020 01; 23(1):104-113. PMID: 31952665.
    Citations: 1     Fields:    Translation:Humans
  22. Grossberg LB, Papamichael K, Leffler DA, Sawhney MS, Feuerstein JD. Patients over Age 75 Are at Increased Risk of Emergency Department Visit and Hospitalization Following Colonoscopy. Dig Dis Sci. 2020 07; 65(7):1964-1970. PMID: 31784850.
    Citations: 2     Fields:    Translation:Humans
  23. Singh P, Singh A, Silvester JA, Sachdeva V, Chen X, Xu H, Leffler DA, Ahuja V, Duerksen DR, Kelly CP, Makharia GK. Inter- and Intra-assay Variation in the Diagnostic Performance of Assays for Anti-tissue Transglutaminase in 2 Populations. Clin Gastroenterol Hepatol. 2020 10; 18(11):2628-2630. PMID: 31546060.
    Citations: 3     Fields:    Translation:Humans
  24. Fudman DI, Papamichael K, Roemi L, Rao V, Falchuk KR, Leffler DA, Feuerstein JD. Effect of Consent and Educational Adjuncts to Consent on Patient Perceptions About Colonoscopy. J Clin Gastroenterol. 2019 09; 53(8):e316-e321. PMID: 30001290.
    Citations:    Fields:    Translation:Humans
  25. Fudman DI, Roemi L, Leffler DA, Feuerstein JD. Letter to the Editor: High Rate of Incomplete Consent for Colonoscopy: Identifying an Area for Improvement in Gastrointestinal Endoscopy. Am J Med Qual. 2020 May/Jun; 35(3):283-284. PMID: 31423820.
    Citations:    Fields:    Translation:Humans
  26. Singh P, Arora A, Strand TA, Leffler DA, Mäki M, Kelly CP, Ahuja V, Makharia GK. Diagnostic Accuracy of Point of Care Tests for Diagnosing Celiac Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2019 08; 53(7):535-542. PMID: 29912751.
    Citations: 7     Fields:    Translation:Humans
  27. Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, Fasano A. Celiac disease: a comprehensive current review. BMC Med. 2019 07 23; 17(1):142. PMID: 31331324.
    Citations: 108     Fields:    Translation:Humans
  28. Kamal A, Fain C, Park A, Wang P, Gonzalez-Velez E, Leffler DA, Hutfless SM. Angiotensin II receptor blockers and gastrointestinal adverse events of resembling sprue-like enteropathy: a systematic review. Gastroenterol Rep (Oxf). 2019 Jun; 7(3):162-167. PMID: 31217979.
    Citations: 7     
  29. Therrien A, Silvester JA, Leffler DA, Kelly CP. Efficacy of Enteric-Release Oral Budesonide in Treatment of Acute Reactions to Gluten in Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2020 01; 18(1):254-256. PMID: 30905717.
    Citations:    Fields:    Translation:Humans
  30. Cichewicz AB, Mearns ES, Taylor A, Boulanger T, Gerber M, Leffler DA, Drahos J, Sanders DS, Thomas Craig KJ, Lebwohl B. Diagnosis and Treatment Patterns in Celiac Disease. Dig Dis Sci. 2019 08; 64(8):2095-2106. PMID: 30820708.
    Citations: 14     Fields:    Translation:Humans
  31. Clerx EM, Silvester J, Leffler D, DeGroote M, Fishman LN. Sequence of acquisition of self-management skills to follow a gluten-free diet by adults with celiac disease. Dig Liver Dis. 2019 08; 51(8):1096-1100. PMID: 30872088.
    Citations: 2     Fields:    Translation:Humans
  32. Ciccocioppo R, Klersy C, Leffler DA, Rogers R, Bennett D, Corazza GR. Systematic review with meta-analysis: Safety and efficacy of local injections of mesenchymal stem cells in perianal fistulas. JGH Open. 2019 Jun; 3(3):249-260. PMID: 31276044.
    Citations: 8     
  33. Mearns ES, Taylor A, Thomas Craig KJ, Puglielli S, Leffler DA, Sanders DS, Lebwohl B, Hadjivassiliou M. Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review. Nutrients. 2019 Feb 12; 11(2). PMID: 30759885.
    Citations: 11     Fields:    Translation:Humans
  34. Mearns ES, Taylor A, Boulanger T, Craig KJ, Gerber M, Leffler DA, Drahos J, Sanders DS, Lebwohl B. Systematic Literature Review of the Economic Burden of Celiac Disease. Pharmacoeconomics. 2019 01; 37(1):45-61. PMID: 30221333.
    Citations: 8     Fields:    Translation:Humans
  35. Singh P, Silvester JA, Leffler D. (Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease. Gastroenterol Clin North Am. 2019 03; 48(1):85-99. PMID: 30711213.
    Citations:    Fields:    Translation:Humans
  36. Ezaz G, Leffler DA, Beach S, Schoen RE, Crockett SD, Gourevitch RA, Rose S, Morris M, Carrell DS, Greer JB, Mehrotra A. Association Between Endoscopist Personality and Rate of Adenoma Detection. Clin Gastroenterol Hepatol. 2019 07; 17(8):1571-1579.e7. PMID: 30326300.
    Citations: 4     Fields:    Translation:Humans
  37. Grossberg LB, Leffler DA. Response. Gastrointest Endosc. 2018 07; 88(1):205. PMID: 29935623.
    Citations:    Fields:    
  38. Singh P, Leffler DA. Editorial: isolated duodenal eosinophilia-clinical condition or just seeing spots? Aliment Pharmacol Ther. 2018 05; 47(9):1327-1328. PMID: 29644740.
    Citations:    Fields:    Translation:HumansCells
  39. Hujoel IA, Johnson DH, Lebwohl B, Leffler D, Kupfer S, Wu TT, Murray JA, Rubio-Tapia A. Tropheryma whipplei Infection (Whipple Disease) in the USA. Dig Dis Sci. 2019 01; 64(1):213-223. PMID: 29572616.
    Citations: 7     Fields:    Translation:HumansCells
  40. Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, Kelly CP, Ahuja V, Makharia GK. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018 06; 16(6):823-836.e2. PMID: 29551598.
    Citations: 221     Fields:    Translation:Humans
  41. Ludvigsson JF, Ciacci C, Green PH, Kaukinen K, Korponay-Szabo IR, Kurppa K, Murray JA, Lundin KEA, Maki MJ, Popp A, Reilly NR, Rodriguez-Herrera A, Sanders DS, Schuppan D, Sleet S, Taavela J, Voorhees K, Walker MM, Leffler DA. Outcome measures in coeliac disease trials: the Tampere recommendations. Gut. 2018 08; 67(8):1410-1424. PMID: 29440464.
    Citations: 30     Fields:    Translation:Humans
  42. Simopoulos T, Leffler D, Barnett S, Campbell D, Lian SJ, Gill JS. Prospective Assessment of Pain and Comfort in Chronic Pain Patients Undergoing Interventional Pain Management Procedures. Pain Med. 2018 02 01; 19(2):336-347. PMID: 28431040.
    Citations:    Fields:    Translation:Humans
  43. Feuerstein JD, Papamichael K, Popejoy S, Nadelson A, Lewandowski JJ, Geissler K, Martinez-Vazquez M, Leffler DA, Ariyabuddhiphongs K, Thukral C, Cheifetz AS. Targeted Physician Education and Standardizing Documentation Improves Documented Reporting with Inflammatory Bowel Disease Quality Measures in a Large Academic and Private Practice. Dig Dis Sci. 2018 01; 63(1):36-45. PMID: 29147880.
    Citations: 2     Fields:    Translation:Humans
  44. Lau MS, Mooney PD, White WL, Rees MA, Wong SH, Kurien M, Trott N, Leffler DA, Hadjivassiliou M, Sanders DS. The Role of an IgA/IgG-Deamidated Gliadin Peptide Point-of-Care Test in Predicting Persistent Villous Atrophy in Patients With Celiac Disease on a Gluten-Free Diet. Am J Gastroenterol. 2017 Dec; 112(12):1859-1867. PMID: 29016564.
    Citations: 6     Fields:    Translation:Humans
  45. Mehrotra A, Morris M, Gourevitch RA, Carrell DS, Leffler DA, Rose S, Greer JB, Crockett SD, Baer A, Schoen RE. Physician characteristics associated with higher adenoma detection rate. Gastrointest Endosc. 2018 03; 87(3):778-786.e5. PMID: 28866456.
    Citations: 20     Fields:    Translation:Humans
  46. Clerx E, Kupfer SS, Leffler DA. Disparities Among Gastrointestinal Disorders in Research Funding From the National Institutes of Health. Gastroenterology. 2017 Oct; 153(4):877-880. PMID: 28867278.
    Citations: 1     Fields:    Translation:Humans
  47. Carrell DS, Schoen RE, Leffler DA, Morris M, Rose S, Baer A, Crockett SD, Gourevitch RA, Dean KM, Mehrotra A. Challenges in adapting existing clinical natural language processing systems to multiple, diverse health care settings. J Am Med Inform Assoc. 2017 Sep 01; 24(5):986-991. PMID: 28419261.
    Citations: 31     Fields:    Translation:Humans
  48. Grossberg LB, Vodonos A, Papamichael K, Novack V, Sawhney M, Leffler DA. Predictors of post-colonoscopy emergency department use. Gastrointest Endosc. 2018 02; 87(2):517-525.e6. PMID: 28859952.
    Citations:    Fields:    Translation:Humans
  49. Snyder GM, Wright SB, Smithey A, Mizrahi M, Sheppard M, Hirsch EB, Chuttani R, Heroux R, Yassa DS, Olafsdottir LB, Davis RB, Anastasiou J, Bapat V, Bidari K, Pleskow DK, Leffler D, Lane B, Chen A, Gold HS, Bartley A, King AD, Sawhney MS. Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes. Gastroenterology. 2017 10; 153(4):1018-1025. PMID: 28711629.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  50. Alonso CD, Braun DA, Patel I, Akbari M, Oh DJ, Jun T, McMasters M, Hammond SP, Glotzbecker B, Cutler C, Leffler DA, Ballen KK, Kelly CP. A multicenter, retrospective, case-cohort study of the epidemiology and risk factors for Clostridium difficile infection among cord blood transplant recipients. Transpl Infect Dis. 2017 Aug; 19(4). PMID: 28544102.
    Citations: 3     Fields:    Translation:Humans
  51. Silvester JA, Graff LA, Rigaux L, Bernstein CN, Leffler DA, Kelly CP, Walker JR, Duerksen DR. Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet. Dig Dis Sci. 2017 09; 62(9):2449-2454. PMID: 28687943.
    Citations: 7     Fields:    Translation:Humans
  52. Silvester JA, Kurada S, Szwajcer A, Kelly CP, Leffler DA, Duerksen DR. Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis. Gastroenterology. 2017 09; 153(3):689-701.e1. PMID: 28545781.
    Citations: 43     Fields:    Translation:Humans
  53. Pinto-Sánchez MI, Causada-Calo N, Bercik P, Ford AC, Murray JA, Armstrong D, Semrad C, Kupfer SS, Alaedini A, Moayyedi P, Leffler DA, Verdú EF, Green P. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. Gastroenterology. 2017 08; 153(2):395-409.e3. PMID: 28431885.
    Citations: 14     Fields:    Translation:HumansAnimals
  54. Jordan R, Shannahan S, Lewis SK, Krishnareddy S, Leffler DA, Green PHR, Lebwohl B. The impact of acid suppression medications and non-steroidal anti-inflammatory drugs on clinical and histologic features in celiac disease. Dig Liver Dis. 2017 Aug; 49(8):883-886. PMID: 28462884.
    Citations:    Fields:    Translation:Humans
  55. Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ, Schuppan D, Helmerhorst EJ. Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ Microbiol. 2017 03 15; 83(6). PMID: 28087531.
    Citations: 19     Fields:    Translation:HumansCells
  56. Leffler DA, Acaster S, Gallop K, Dennis M, Kelly CP, Adelman DC. A Novel Patient-Derived Conceptual Model of the Impact of Celiac Disease in Adults: Implications for Patient-Reported Outcome and Health-Related Quality-of-Life Instrument Development. Value Health. 2017 04; 20(4):637-643. PMID: 28408006.
    Citations: 9     Fields:    Translation:Humans
  57. Hoerter NA, Shannahan SE, Suarez J, Lewis SK, Green PHR, Leffler DA, Lebwohl B. Diagnostic Yield of Isolated Deamidated Gliadin Peptide Antibody Elevation for Celiac Disease. Dig Dis Sci. 2017 05; 62(5):1272-1276. PMID: 28161854.
    Citations: 6     Fields:    Translation:Humans
  58. Shields HM. How to Create an Unfunded Teaching Fellowship During the Gastroenterology Fellowship That Positively Impacts Subsequent Teaching Activities and Career Path. Gastroenterology. 2017 03; 152(4):689-692. PMID: 28153607.
    Citations: 1     Fields:    Translation:Humans
  59. Shannahan S, Leffler DA. Diagnosis and Updates in Celiac Disease. Gastrointest Endosc Clin N Am. 2017 Jan; 27(1):79-92. PMID: 27908520.
    Citations: 12     Fields:    Translation:Humans
  60. Silvester JA, Leffler DA. Is Autoimmunity Infectious? The Effect of Gastrointestinal Viral Infections and Vaccination on Risk of Celiac Disease Autoimmunity. Clin Gastroenterol Hepatol. 2017 05; 15(5):703-705. PMID: 28017844.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  61. Kabbani TA, Pallav K, Dowd SE, Villafuerte-Galvez J, Vanga RR, Castillo NE, Hansen J, Dennis M, Leffler DA, Kelly CP. Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers. Gut Microbes. 2017 01 02; 8(1):17-32. PMID: 27973989.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  62. Patel I, Wungjiranirun M, Theethira T, Villafuerte-Galvez J, Castillo N, Akbari M, Alonso CD, Leffler DA, Kelly CP. Lack of adherence to SHEA-IDSA treatment guidelines for Clostridium difficile infection is associated with increased mortality. J Antimicrob Chemother. 2017 02; 72(2):574-581. PMID: 28115504.
    Citations: 6     Fields:    Translation:HumansCells
  63. Hindryckx P, Levesque BG, Holvoet T, Durand S, Tang CM, Parker C, Khanna R, Shackelton LM, D'Haens G, Sandborn WJ, Feagan BG, Lebwohl B, Leffler DA, Jairath V. Disease activity indices in coeliac disease: systematic review and recommendations for clinical trials. Gut. 2018 01; 67(1):61-69. PMID: 27799282.
    Citations: 12     Fields:    Translation:Humans
  64. Rubio-Tapia A, Malamut G, Verbeek WH, van Wanrooij RL, Leffler DA, Niveloni SI, Arguelles-Grande C, Lahr BD, Zinsmeister AR, Murray JA, Kelly CP, Bai JC, Green PH, Daum S, Mulder CJ, Cellier C. Creation of a model to predict survival in patients with refractory coeliac disease using a multinational registry. Aliment Pharmacol Ther. 2016 10; 44(7):704-14. PMID: 27485029.
    Citations: 6     Fields:    Translation:HumansCells
  65. Emilsson L, Murray JA, Leffler DA, Ludvigsson JF. Cancer in first-degree relatives of people with celiac disease. Medicine (Baltimore). 2016 Aug; 95(32):e4588. PMID: 27512889.
    Citations:    Fields:    Translation:Humans
  66. Kothari D, Feuerstein JD, Moss L, D'Souza J, Montanaro K, Leffler DA, Sheth SG. An open-access endoscopy screen correctly and safely identifies patients for conscious sedation. Gastroenterol Rep (Oxf). 2016 Nov; 4(4):281-286. PMID: 27478195.
    Citations:    
  67. Leffler D, Kupfer SS, Lebwohl B, Bugin K, Griebel D, Lathrop JT, Lee JJ, Mulberg AE, Papadopoulos E, Tomaino J, Crowe SE. Development of Celiac Disease Therapeutics: Report of the Third Gastroenterology Regulatory Endpoints and Advancement of Therapeutics Workshop. Gastroenterology. 2016 09; 151(3):407-11. PMID: 27456385.
    Citations: 10     Fields:    Translation:Humans
  68. Kurada S, Yadav A, Leffler DA. Current and novel therapeutic strategies in celiac disease. Expert Rev Clin Pharmacol. 2016 Sep; 9(9):1211-23. PMID: 27322016.
    Citations: 10     Fields:    Translation:HumansAnimals
  69. Kurada S, Veeraraghavan G, Kaswala D, Hansen J, Cohen D, Kelly C, Leffler D. Low testosterone in non-responsive coeliac disease: A case series, case-control study with comparisons to the National Health and Nutrition Examination Survey. Dig Liver Dis. 2016 Oct; 48(10):1155-61. PMID: 27378706.
    Citations:    Fields:    Translation:Humans
  70. Feuerstein JD, Castillo NE, Akbari M, Belkin E, Lewandowski JJ, Hurley CM, Lloyd S, Leffler DA, Cheifetz AS. Systematic Analysis and Critical Appraisal of the Quality of the Scientific Evidence and Conflicts of Interest in Practice Guidelines (2005-2013) for Barrett's Esophagus. Dig Dis Sci. 2016 10; 61(10):2812-2822. PMID: 27307064.
    Citations: 7     Fields:    Translation:Humans
  71. Feuerstein JD, Ketwaroo G, Tewani SK, Cheesman A, Trivella J, Raptopoulos V, Leffler DA. Localizing Acute Lower Gastrointestinal Hemorrhage: CT Angiography Versus Tagged RBC Scintigraphy. AJR Am J Roentgenol. 2016 Sep; 207(3):578-84. PMID: 27303989.
    Citations: 3     Fields:    Translation:HumansCells
  72. Adriaanse MP, Leffler DA, Kelly CP, Schuppan D, Najarian RM, Goldsmith JD, Buurman WA, Vreugdenhil AC. Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol. 2016 07; 111(7):1014-22. PMID: 27185075.
    Citations: 15     Fields:    Translation:Humans
  73. Oza SS, Akbari M, Kelly CP, Hansen J, Theethira T, Tariq S, Dennis M, Leffler DA. Socioeconomic Risk Factors for Celiac Disease Burden and Symptoms. J Clin Gastroenterol. 2016 Apr; 50(4):307-12. PMID: 26084006.
    Citations: 5     Fields:    Translation:Humans
  74. Wungjiranirun M, Kelly CP, Leffler DA. Current Status of Celiac Disease Drug Development. Am J Gastroenterol. 2016 06; 111(6):779-86. PMID: 27021196.
    Citations: 9     Fields:    Translation:Humans
  75. Roy A, Mehra S, Kelly CP, Tariq S, Pallav K, Dennis M, Peer A, Lebwohl B, Green PH, Leffler DA. The association between socioeconomic status and the symptoms at diagnosis of celiac disease: a retrospective cohort study. Therap Adv Gastroenterol. 2016 Jul; 9(4):495-502. PMID: 27366218.
    Citations: 8     
  76. Hung A, Marshall J, Barnett S, Falchuk ZM, Sawhney M, Leffler DA. Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy. J Clin Gastroenterol. 2016 Mar; 50(3):e25-9. PMID: 25626630.
    Citations: 1     Fields:    Translation:Humans
  77. Barnett S, Hung A, Tsao R, Sheehan J, Bukoye B, Sheth SG, Leffler DA. Capnographic Monitoring of Moderate Sedation During Low-Risk Screening Colonoscopy Does Not Improve Safety or Patient Satisfaction: A Prospective Cohort Study. Am J Gastroenterol. 2016 Mar; 111(3):388-94. PMID: 26832654.
    Citations: 6     Fields:    Translation:Humans
  78. Pallav K, Xu H, Leffler DA, Kabbani T, Kelly CP. Immunoglobulin A deficiency in celiac disease in the United States. J Gastroenterol Hepatol. 2016 Jan; 31(1):133-7. PMID: 26412412.
    Citations: 12     Fields:    Translation:Humans
  79. Patwardhan VR, Feuerstein JD, Sengupta N, Lewandowski JJ, Tsao R, Kothari D, Anastopoulos HT, Doyle RB, Leffler DA, Sheth SG. Fellowship Colonoscopy Training and Preparedness for Independent Gastroenterology Practice. J Clin Gastroenterol. 2016 Jan; 50(1):45-51. PMID: 26125461.
    Citations: 11     Fields:    Translation:Humans
  80. Tapper EB, Leffler DA. The Morbidity and Mortality Conference in Gastroenterology and Hepatology: An Important Cornerstone of Patient Safety and Optimal Care. Gastroenterology. 2016 Jan; 150(1):19-23. PMID: 26615118.
    Citations: 2     Fields:    Translation:Humans
  81. Silvester JA, Leffler DA. Recent Advances in Celiac Disease from TTG to Gluten in Pee. Clin Transl Gastroenterol. 2015 Nov 12; 6:e125. PMID: 26561989.
    Citations:    Fields:    
  82. Feuerstein JD, Castillo NE, Siddique SS, Lewandowski JJ, Geissler K, Martinez-Vazquez M, Thukral C, Leffler DA, Cheifetz AS. Poor Documentation of Inflammatory Bowel Disease Quality Measures in Academic, Community, and Private Practice. Clin Gastroenterol Hepatol. 2016 Mar; 14(3):421-428.e2. PMID: 26499928.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  83. Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D, Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 01; 309(11):G910-7. PMID: 26505973.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  84. Marcondes FO, Dean KM, Schoen RE, Leffler DA, Rose S, Morris M, Mehrotra A. The impact of exclusion criteria on a physician's adenoma detection rate. Gastrointest Endosc. 2015 Oct; 82(4):668-75. PMID: 26385275.
    Citations: 8     Fields:    Translation:Humans
  85. Abdul-Baki H, Schoen RE, Dean K, Rose S, Leffler DA, Kuganeswaran E, Morris M, Carrell D, Mehrotra A. Public reporting of colonoscopy quality is associated with an increase in endoscopist adenoma detection rate. Gastrointest Endosc. 2015 Oct; 82(4):676-82. PMID: 26385276.
    Citations: 16     Fields:    Translation:Humans
  86. Lebwohl B, Leffler DA. Reply. Clin Gastroenterol Hepatol. 2016 Jan; 14(1):169. PMID: 26432478.
    Citations:    Fields:    Translation:Humans
  87. Sengupta N, Tapper EB, Patwardhan VR, Ketwaroo GA, Thaker AM, Leffler DA, Feuerstein JD. High Glasgow Blatchford Score at admission is associated with recurrent bleeding after discharge for patients hospitalized with upper gastrointestinal bleeding. Endoscopy. 2016 Jan; 48(1):9-15. PMID: 26340604.
    Citations: 5     Fields:    Translation:Humans
  88. Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015 Oct; 12(10):561-71. PMID: 26260366.
    Citations: 70     Fields:    Translation:Humans
  89. Villafuerte-Galvez J, Vanga RR, Dennis M, Hansen J, Leffler DA, Kelly CP, Mukherjee R. Factors governing long-term adherence to a gluten-free diet in adult patients with coeliac disease. Aliment Pharmacol Ther. 2015 Sep; 42(6):753-60. PMID: 26206401.
    Citations: 22     Fields:    Translation:Humans
  90. Song L, Zhao M, Duffy DC, Hansen J, Shields K, Wungjiranirun M, Chen X, Xu H, Leffler DA, Sambol SP, Gerding DN, Kelly CP, Pollock NR. Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool. J Clin Microbiol. 2015 Oct; 53(10):3204-12. PMID: 26202120.
    Citations: 19     Fields:    Translation:Humans
  91. Leffler DA, Lamont JT. Clostridium difficile Infection. N Engl J Med. 2015 07 16; 373(3):287-8. PMID: 26176396.
    Citations: 86     Fields:    Translation:HumansCells
  92. Akbari M, Vodonos A, Silva G, Wungjiranirun M, Leffler DA, Kelly CP, Novack V. The impact of PCR on Clostridium difficile detection and clinical outcomes. J Med Microbiol. 2015 Sep; 64(9):1082-1086. PMID: 26297376.
    Citations: 5     Fields:    Translation:HumansCells
  93. Castillo NE, Vanga RR, Theethira TG, Rubio-Tapia A, Murray JA, Villafuerte J, Bonder A, Mukherjee R, Hansen J, Dennis M, Kelly CP, Leffler DA. Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population. Am J Gastroenterol. 2015 Aug; 110(8):1216-22. PMID: 26150087.
    Citations: 12     Fields:    Translation:Humans
  94. Sengupta N, Tapper EB, Patwardhan VR, Ketwaroo GA, Thaker AM, Leffler DA, Feuerstein JD. Risk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding. Mayo Clin Proc. 2015 Aug; 90(8):1021-9. PMID: 26141075.
    Citations: 6     Fields:    Translation:Humans
  95. Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, Cellier C, Cristofori F, de Magistris L, Dolinsek J, Dieterich W, Francavilla R, Hadjivassiliou M, Holtmeier W, Körner U, Leffler DA, Lundin KE, Mazzarella G, Mulder CJ, Pellegrini N, Rostami K, Sanders D, Skodje GI, Schuppan D, Ullrich R, Volta U, Williams M, Zevallos VF, Zopf Y, Fasano A. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients. 2015 Jun 18; 7(6):4966-77. PMID: 26096570.
    Citations: 139     Fields:    Translation:Humans
  96. Kaswala DH, Veeraraghavan G, Kelly CP, Leffler DA. Celiac Disease: Diagnostic Standards and Dilemmas. Diseases. 2015 Jun 16; 3(2):86-101. PMID: 28943611.
    Citations: 4     
  97. Shields HM, Leffler DA, Peters AS, Llerena-Quinn R, Nambudiri VE, White AA, Hayward JN, Pelletier SR. A faculty development program integrating cross-cultural care into a gastrointestinal pathophysiology tutorial benefits students, tutors, and the course. Adv Physiol Educ. 2015 Jun; 39(2):81-90. PMID: 26031723.
    Citations:    Fields:    Translation:Humans
  98. Pimentel M, Morales W, Rezaie A, Marsh E, Lembo A, Mirocha J, Leffler DA, Marsh Z, Weitsman S, Chua KS, Barlow GM, Bortey E, Forbes W, Yu A, Chang C. Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects. PLoS One. 2015; 10(5):e0126438. PMID: 25970536.
    Citations: 41     Fields:    Translation:Humans
  99. Sengupta N, Tapper EB, Corban C, Sommers T, Leffler DA, Lembo AJ. The clinical predictors of aetiology and complications among 173 patients presenting to the Emergency Department with oesophageal food bolus impaction from 2004-2014. Aliment Pharmacol Ther. 2015 Jul; 42(1):91-8. PMID: 25963885.
    Citations: 7     Fields:    Translation:HumansCells
  100. Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Oct; 9(9-10):953-64. PMID: 25726832.
    Citations: 4     Fields:    Translation:HumansCells
  101. Na X, Martin AJ, Sethi S, Kyne L, Garey KW, Flores SW, Hu M, Shah DN, Shields K, Leffler DA, Kelly CP. A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection. PLoS One. 2015; 10(4):e0123405. PMID: 25906284.
    Citations: 15     Fields:    Translation:HumansCells
  102. Adriaanse M, Leffler DA. Serum markers in the clinical management of celiac disease. Dig Dis. 2015; 33(2):236-243. PMID: 25925929.
    Citations: 4     Fields:    Translation:Humans
  103. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med. 2015 Apr 16; 372(16):1539-48. PMID: 25875259.
    Citations: 281     Fields:    Translation:HumansCellsPHPublic Health
  104. Veeraraghavan G, Leffler DA, Kaswala DH, Mukherjee R. Celiac disease 2015 update: new therapies. Expert Rev Gastroenterol Hepatol. 2015 Jul; 9(7):913-27. PMID: 25864708.
    Citations: 9     Fields:    Translation:HumansCells
  105. Gashin L, Villafuerte-Galvez J, Leffler DA, Obuch J, Cheifetz AS. Utility of CT in the emergency department in patients with ulcerative colitis. Inflamm Bowel Dis. 2015 Apr; 21(4):793-800. PMID: 25742397.
    Citations: 3     Fields:    Translation:Humans
  106. Lebwohl B, Leffler DA. Exploring the Strange New World of Non-Celiac Gluten Sensitivity. Clin Gastroenterol Hepatol. 2015 Sep; 13(9):1613-5. PMID: 25796575.
    Citations: 2     Fields:    Translation:Humans
  107. Sengupta N, Feuerstein JD, Patwardhan VR, Tapper EB, Ketwaroo GA, Thaker AM, Leffler DA. Erratum: the risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study. Am J Gastroenterol. 2015 Mar; 110(3):480. PMID: 25743723.
    Citations:    Fields:    
  108. Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, Rasmussen H, Wang C, Bercik P, Bachir NM, Murray JA. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015 Jun; 148(7):1311-9.e6. PMID: 25683116.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  109. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in diagnosis and management of celiac disease. Gastroenterology. 2015 May; 148(6):1175-86. PMID: 25662623.
    Citations: 65     Fields:    Translation:HumansAnimals
  110. Sengupta N, Feuerstein JD, Patwardhan VR, Tapper EB, Ketwaroo GA, Thaker AM, Leffler DA. The risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study. Am J Gastroenterol. 2015 Feb; 110(2):328-35. PMID: 25512338.
    Citations: 29     Fields:    Translation:Humans
  111. Novack L, Kogan S, Gimpelevich L, Howell M, Borer A, Kelly CP, Leffler DA, Novack V. Acid suppression therapy does not predispose to Clostridium difficile infection: the case of the potential bias. PLoS One. 2014; 9(10):e110790. PMID: 25343667.
    Citations: 22     Fields:    Translation:HumansCells
  112. Castillo NE, Theethira TG, Leffler DA. The present and the future in the diagnosis and management of celiac disease. Gastroenterol Rep (Oxf). 2015 Feb; 3(1):3-11. PMID: 25326000.
    Citations: 20     
  113. Feuerstein JD, Lewandowski JJ, Martinez-Vazquez M, Leffler DA, Cheifetz AS. Documented compliance with inflammatory bowel disease quality measures is poor. Dig Dis Sci. 2015 Feb; 60(2):339-44. PMID: 25311583.
    Citations: 10     Fields:    Translation:Humans
  114. Leffler DA, Bukoye B, Sawhney M, Berzin T, Sands K, Chowdary S, Shah A, Barnett S. Development and validation of the PROcedural Sedation Assessment Survey (PROSAS) for assessment of procedural sedation quality. Gastrointest Endosc. 2015 Jan; 81(1):194-203.e1. PMID: 25293829.
    Citations: 5     Fields:    Translation:Humans
  115. Kabbani TA, Vanga RR, Leffler DA, Villafuerte J, Pallav K, Hansen J, Mukherjee R, Dennis M, Kelly C. Response to Aziz et al. Am J Gastroenterol. 2014 Sep; 109(9):1499-500. PMID: 25196881.
    Citations:    Fields:    Translation:Humans
  116. Feuerstein JD, Leffler DA, Cheifetz AS. Colonoscopy is appropriately utilized in most cases following a fair bowel prep. Am J Gastroenterol. 2014 Aug; 109(8):1289. PMID: 25091247.
    Citations:    Fields:    Translation:Humans
  117. Leffler DA, Kelly CP. The cost of a loaf of bread in symptomless celiac disease. Gastroenterology. 2014 Sep; 147(3):557-9. PMID: 25072177.
    Citations: 3     Fields:    Translation:Humans
  118. Shah S, Akbari M, Vanga R, Kelly CP, Hansen J, Theethira T, Tariq S, Dennis M, Leffler DA. Patient perception of treatment burden is high in celiac disease compared with other common conditions. Am J Gastroenterol. 2014 Sep; 109(9):1304-11. PMID: 24980880.
    Citations: 59     Fields:    Translation:Humans
  119. Pallav K, Dowd SE, Villafuerte J, Yang X, Kabbani T, Hansen J, Dennis M, Leffler DA, Newburg DS, Kelly CP. Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014 Jul 01; 5(4):458-67. PMID: 25006989.
    Citations: 20     Fields:    Translation:HumansAnimals
  120. Moss AC, Lillis Y, Edwards George JB, Choudhry NK, Berg AH, Cheifetz AS, Horowitz G, Leffler DA. Attitudes to mesalamine questionnaire: a novel tool to predict mesalamine nonadherence in patients with IBD. Am J Gastroenterol. 2014 Dec; 109(12):1850-5. PMID: 24913040.
    Citations: 5     Fields:    Translation:Humans
  121. Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, Green PH, Hadjivassiliou M, Holdoway A, van Heel DA, Kaukinen K, Leffler DA, Leonard JN, Lundin KE, McGough N, Davidson M, Murray JA, Swift GL, Walker MM, Zingone F, Sanders DS. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014 Aug; 63(8):1210-28. PMID: 24917550.
    Citations: 280     Fields:    Translation:Humans
  122. Feuerstein JD, Leffler DA, Cheifetz AS. In reply--Clinical practice guidelines: still miles to go... Mayo Clin Proc. 2014 Jun; 89(6):860-1. PMID: 24943703.
    Citations:    Fields:    Translation:Humans
  123. Pallav K, Kabbani T, Tariq S, Vanga R, Kelly CP, Leffler DA. Clinical utility of celiac disease-associated HLA testing. Dig Dis Sci. 2014 Sep; 59(9):2199-206. PMID: 24705698.
    Citations: 14     Fields:    Translation:Humans
  124. Kabbani TA, Vanga RR, Leffler DA, Villafuerte-Galvez J, Pallav K, Hansen J, Mukherjee R, Dennis M, Kelly CP. Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis. Am J Gastroenterol. 2014 May; 109(5):741-6; quiz 747. PMID: 24619056.
    Citations: 25     Fields:    Translation:Humans
  125. Theethira TG, Dennis M, Leffler DA. Nutritional consequences of celiac disease and the gluten-free diet. Expert Rev Gastroenterol Hepatol. 2014 Feb; 8(2):123-9. PMID: 24417260.
    Citations: 34     Fields:    Translation:Humans
  126. Ridge CA, Hobbs BD, Bukoye BA, Aronson MD, Boiselle PM, Leffler DA, Sternberg SB, Roberts DH. Incidentally detected lung nodules: clinical predictors of adherence to Fleischner Society surveillance guidelines. J Comput Assist Tomogr. 2014 Jan-Feb; 38(1):89-95. PMID: 24424558.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  127. Feuerstein JD, Akbari M, Gifford AE, Hurley CM, Leffler DA, Sheth SG, Cheifetz AS. Systematic analysis underlying the quality of the scientific evidence and conflicts of interest in interventional medicine subspecialty guidelines. Mayo Clin Proc. 2014 Jan; 89(1):16-24. PMID: 24388018.
    Citations: 12     Fields:    Translation:Humans
  128. Sethi S, Wadhwa V, Thaker A, Chuttani R, Pleskow DK, Barnett SR, Leffler DA, Berzin TM, Sethi N, Sawhney MS. Propofol versus traditional sedative agents for advanced endoscopic procedures: a meta-analysis. Dig Endosc. 2014 Jul; 26(4):515-24. PMID: 24354404.
    Citations: 22     Fields:    Translation:Humans
  129. Feuerstein JD, Leffler DA. Acute gastrointestinal bleeding. Ann Intern Med. 2013 Dec 03; 159(11):793. PMID: 24297202.
    Citations:    Fields:    Translation:Humans
  130. Feuerstein JD, Leffler DA, Sheth SG, Cheifetz AS. An appraisal of the current state of gastroenterology practice guidelines. Gastroenterology. 2013 Dec; 145(6):1175-8. PMID: 24409477.
    Citations:    Fields:    Translation:Humans
  131. Bukoye B, Leffler D. Topical anesthetic-induced methemoglobinemia and veterans affairs hospitals--reply. JAMA Intern Med. 2013 Nov 25; 173(21):2013-4. PMID: 24276057.
    Citations:    Fields:    Translation:Humans
  132. Feuerstein JD, Gifford AE, Akbari M, Goldman J, Leffler DA, Sheth SG, Cheifetz AS. Systematic analysis underlying the quality of the scientific evidence and conflicts of interest in gastroenterology practice guidelines. Am J Gastroenterol. 2013 Nov; 108(11):1686-93. PMID: 24192942.
    Citations: 9     Fields:    Translation:Humans
  133. Feuerstein JD, Leffler DA, Cheifetz AS. Letter: inflammatory bowel disease guidelines and conflicts of interest--authors' reply. Aliment Pharmacol Ther. 2013 Aug; 38(4):445-6. PMID: 23855400.
    Citations:    Fields:    Translation:Humans
  134. Feuerstein JD, Leffler DA, Cheifetz AS. Letter: international IBD practice guidelines -- authors' reply. Aliment Pharmacol Ther. 2013 Aug; 38(3):326-7. PMID: 23808419.
    Citations:    Fields:    Translation:Humans
  135. Vanga R, Leffler DA. Gluten sensitivity: not celiac and not certain. Gastroenterology. 2013 Aug; 145(2):276-9. PMID: 23806541.
    Citations: 7     Fields:    Translation:Humans
  136. Chowdhary S, Bukoye B, Bhansali AM, Carbo AR, Adra M, Barnett S, Aronson MD, Leffler DA. Risk of topical anesthetic-induced methemoglobinemia: a 10-year retrospective case-control study. JAMA Intern Med. 2013 May 13; 173(9):771-6. PMID: 23546303.
    Citations: 5     Fields:    Translation:Humans
  137. Ferreira J, Akbari M, Gashin L, Cullen G, Moss A, Leffler DA, Aronson M, Cheifetz AS. Prevalence and lifetime risk of endoscopy-related complications among patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013 Oct; 11(10):1288-93. PMID: 23669305.
    Citations: 3     Fields:    Translation:Humans
  138. Feuerstein JD, Akbari M, Gifford AE, Cullen G, Leffler DA, Sheth SG, Cheifetz AS. Systematic review: the quality of the scientific evidence and conflicts of interest in international inflammatory bowel disease practice guidelines. Aliment Pharmacol Ther. 2013 May; 37(10):937-46. PMID: 23550536.
    Citations: 12     Fields:    Translation:Humans
  139. Lahiff C, Safaie P, Awais A, Akbari M, Gashin L, Sheth S, Lembo A, Leffler D, Moss AC, Cheifetz AS. The Crohn's disease activity index (CDAI) is similarly elevated in patients with Crohn's disease and in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2013 Apr; 37(8):786-94. PMID: 23432394.
    Citations: 29     Fields:    Translation:Humans
  140. Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN. Commentary: larazotide acetate - an exciting new development for coeliac patients? Authors' reply. Aliment Pharmacol Ther. 2013 Feb; 37(4):496-7. PMID: 23336684.
    Citations:    Fields:    Translation:Humans
  141. Kabbani TA, Kelly CP, Betensky RA, Hansen J, Pallav K, Villafuerte-Gálvez JA, Vanga R, Mukherjee R, Novero A, Dennis M, Leffler DA. Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. Gastroenterology. 2013 May; 144(5):912-917.e1. PMID: 23354016.
    Citations: 15     Fields:    Translation:Humans
  142. Feuerstein JD, Leffler DA. Colonoscopy and polyp characteristics. Ann Intern Med. 2013 Jan 15; 158(2):141-2. PMID: 23318327.
    Citations:    Fields:    Translation:Humans
  143. Tanpowpong P, Broder-Fingert S, Obuch JC, Rahni DO, Katz AJ, Leffler DA, Kelly CP, Camargo CA. Multicenter study on the value of ICD-9-CM codes for case identification of celiac disease. Ann Epidemiol. 2013 Mar; 23(3):136-42. PMID: 23313264.
    Citations: 11     Fields:    Translation:Humans
  144. Lown BA, Gareis K, Kormos W, Kriegel G, Leffler D, Richter J, Ship A, Weil E, Manning C. Communicate, don't litigate: The Schwartz Center Connections Program. J Healthc Risk Manag. 2013; 33(1):3-10. PMID: 23861118.
    Citations:    Fields:    Translation:Humans
  145. Feuerstein JD, Leffler DA, Cheifetz AS. How physicians interpret research funding disclosures. N Engl J Med. 2012 12 13; 367(24):2358-9; author reply 2360. PMID: 23234527.
    Citations:    Fields:    Translation:Humans
  146. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V, Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 2012 Dec 17; 209(13):2395-408. PMID: 23209313.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  147. Panzer RM, Dennis M, Kelly CP, Weir D, Leichtner A, Leffler DA. Navigating the gluten-free diet in college. J Pediatr Gastroenterol Nutr. 2012 Dec; 55(6):740-4. PMID: 22732896.
    Citations: 4     Fields:    Translation:Humans
  148. Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther. 2013 Jan; 37(2):252-62. PMID: 23163616.
    Citations: 61     Fields:    Translation:HumansCells
  149. Leffler D, Vanga R, Mukherjee R. Mild enteropathy celiac disease: a wolf in sheep's clothing? Clin Gastroenterol Hepatol. 2013 Mar; 11(3):259-61. PMID: 23142601.
    Citations: 8     Fields:    Translation:Humans
  150. Tanpowpong P, Obuch JC, Jiang H, McCarty CE, Katz AJ, Leffler DA, Kelly CP, Weir DC, Leichtner AM, Camargo CA. Multicenter study on season of birth and celiac disease: evidence for a new theoretical model of pathogenesis. J Pediatr. 2013 Mar; 162(3):501-4. PMID: 23084709.
    Citations: 8     Fields:    Translation:Humans
  151. Kheraj R, Tewani SK, Ketwaroo G, Leffler DA. Quality improvement in gastroenterology clinical practice. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1305-14. PMID: 22902758.
    Citations: 4     Fields:    Translation:Humans
  152. Nasr I, Leffler DA, Ciclitira PJ. Management of celiac disease. Gastrointest Endosc Clin N Am. 2012 Oct; 22(4):695-704. PMID: 23083987.
    Citations: 7     Fields:    Translation:Humans
  153. Leffler DA, Kelly CP, Abdallah HZ, Colatrella AM, Harris LA, Leon F, Arterburn LA, Paterson BM, Lan ZH, Murray JA. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol. 2012 Oct; 107(10):1554-62. PMID: 22825365.
    Citations: 55     Fields:    Translation:HumansCellsPHPublic Health
  154. Martinez FJ, Leffler DA, Kelly CP. Clostridium difficile outbreaks: prevention and treatment strategies. Risk Manag Healthc Policy. 2012; 5:55-64. PMID: 22826646.
    Citations: 13     
  155. Kabbani TA, Leffler DA. Letter: rising incidence of obesity in the coeliac population - a malady or maladaptation? Authors' reply. Aliment Pharmacol Ther. 2012 Jun; 35(12):1484. PMID: 22582842.
    Citations:    
  156. Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease. Gut. 2013 Jul; 62(7):996-1004. PMID: 22619366.
    Citations: 74     Fields:    Translation:Humans
  157. Carbo AR, Blanco PG, Graeme-Cooke F, Misdraji J, Kappler S, Shaffer K, Goldsmith JD, Berzin T, Leffler D, Najarian R, Sepe P, Kaplan J, Pitman M, Goldman H, Pelletier S, Hayward JN, Shields HM. Revitalizing pathology laboratories in a gastrointestinal pathophysiology course using multimedia and team-based learning techniques. Pathol Res Pract. 2012 May 15; 208(5):300-5. PMID: 22464153.
    Citations:    Fields:    Translation:Humans
  158. Leffler DA, Kheraj R, Bhansali A, Yamanaka H, Neeman N, Sheth S, Sawhney M, Lamont JT, Aronson MD. Adenoma detection rates vary minimally with time of day and case rank: a prospective study of 2139 first screening colonoscopies. Gastrointest Endosc. 2012 Mar; 75(3):554-60. PMID: 22341102.
    Citations: 15     Fields:    Translation:Humans
  159. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan; 62(1):43-52. PMID: 22345659.
    Citations: 407     Fields:    Translation:Humans
  160. Kabbani TA, Goldberg A, Kelly CP, Pallav K, Tariq S, Peer A, Hansen J, Dennis M, Leffler DA. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther. 2012 Mar; 35(6):723-9. PMID: 22316503.
    Citations: 56     Fields:    Translation:Humans
  161. Pallav K, Leffler DA, Bennett M, Tariq S, Xu H, Kabbani T, Moss AC, Dennis M, Kelly CP, Schuppan D. Open conformation tissue transglutaminase testing for celiac dietary assessment. Dig Liver Dis. 2012 May; 44(5):375-8. PMID: 22261352.
    Citations: 2     Fields:    Translation:Humans
  162. Leffler DA, Lamont JT. Editorial: not so nosocomial anymore: the growing threat of community-acquired Clostridium difficile. Am J Gastroenterol. 2012 Jan; 107(1):96-8. PMID: 22218031.
    Citations: 9     Fields:    Translation:Humans
  163. Pallav K, Leffler DA, Tariq S, Kabbani T, Hansen J, Peer A, Bhansali A, Najarian R, Kelly CP. Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice. Aliment Pharmacol Ther. 2012 Feb; 35(3):380-90. PMID: 22145590.
    Citations: 35     Fields:    Translation:Humans
  164. Leffler D. Celiac disease diagnosis and management: a 46-year-old woman with anemia. JAMA. 2011 Oct 12; 306(14):1582-92. PMID: 21990301.
    Citations: 13     Fields:    Translation:Humans
  165. Mukherjee R, Kelly CP, Leffler DA. Gastrointestinal cancer in celiac disease: "the first days are the hardest days, don't you worry anymore?". Clin Gastroenterol Hepatol. 2012 Jan; 10(1):4-6. PMID: 21982968.
    Citations: 4     Fields:    Translation:Humans
  166. Germansky KA, Leffler DA. Development of quality measures for monitoring and improving care in gastroenterology. Best Pract Res Clin Gastroenterol. 2011 Jun; 25(3):387-95. PMID: 21764006.
    Citations: 2     Fields:    Translation:Humans
  167. Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a north american referral center. Am J Gastroenterol. 2011 May; 106(5):923-8. PMID: 21468013.
    Citations: 36     Fields:    Translation:Humans
  168. Leffler DA, Neeman N, Rabb JM, Shin JY, Landon BE, Pallav K, Falchuk ZM, Aronson MD. An alerting system improves adherence to follow-up recommendations from colonoscopy examinations. Gastroenterology. 2011 Apr; 140(4):1166-1173.e1-3. PMID: 21237167.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  169. Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for the treatment of refractory celiac disease type I. J Clin Gastroenterol. 2011 Jan; 45(1):30-3. PMID: 20871406.
    Citations: 9     Fields:    Translation:Humans
  170. Leffler DA, Kelly CP. Celiac disease and gastroesophageal reflux disease: yet another presentation for a clinical chameleon. Clin Gastroenterol Hepatol. 2011 Mar; 9(3):192-3. PMID: 21145426.
    Citations: 3     Fields:    Translation:Humans
  171. Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010 Dec; 105(12):2520-4. PMID: 21131921.
    Citations: 105     Fields:    Translation:Humans
  172. Leffler DA, Kheraj R, Garud S, Neeman N, Nathanson LA, Kelly CP, Sawhney M, Landon B, Doyle R, Rosenberg S, Aronson M. The incidence and cost of unexpected hospital use after scheduled outpatient endoscopy. Arch Intern Med. 2010 Oct 25; 170(19):1752-7. PMID: 20975024.
    Citations: 30     Fields:    Translation:Humans
  173. Shah S, Leffler D. Celiac disease: an underappreciated issue in women’s health. Womens Health (Lond). 2010 Sep; 6(5):753-66. PMID: 20887172.
    Citations: 9     Fields:    Translation:Humans
  174. Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D, Dennis M, Leffler DA. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol. 2010 Jul; 8(7):587-90. PMID: 20417725.
    Citations: 26     Fields:    Translation:Humans
  175. Leffler D. By the way, doctor. I have a mild case of celiac disease. Do the villi ever recover after wheat gluten is given up? I am really tired of gluten-free food! Harv Health Lett. 2010 Mar; 35(5):8. PMID: 27023986.
    Citations:    Fields:    Translation:HumansAnimals
  176. Shields HM, Nambudiri VE, Leffler DA, Akileswaran C, Gurrola ER, Jimenez R, Saltzman A, Samuel PA, Wong K, White Iii AA, Hafler JP, Hayward JN, Pelletier SR, O'Farrell RP, Blanco PG, Kappler SM, Llerena-Quinn R. Using medical students to enhance curricular integration of cross-cultural content. Kaohsiung J Med Sci. 2009 Sep; 25(9):493-502. PMID: 19717368.
    Citations: 2     Fields:    Translation:Humans
  177. Leffler DA, Dennis M, Edwards George J, Jamma S, Cook EF, Schuppan D, Kelly CP. A validated disease-specific symptom index for adults with celiac disease. Clin Gastroenterol Hepatol. 2009 Dec; 7(12):1328-34, 1334.e1-3. PMID: 19665584.
    Citations: 33     Fields:    Translation:Humans
  178. Leffler DA, Lamont JT. A 69-year-old woman presenting to the hospital with 48 hours of abdominal pain and diarrhea. Clin Gastroenterol Hepatol. 2009 Oct; 7(10):1046-8. PMID: 19500692.
    Citations: 1     Fields:    Translation:HumansCells
  179. Leffler DA, Lamont JT. Treatment of Clostridium difficile-associated disease. Gastroenterology. 2009 May; 136(6):1899-912. PMID: 19457418.
    Citations: 49     Fields:    Translation:HumansCells
  180. Hyett B, Martinez FJ, Gill BM, Mehra S, Lembo A, Kelly CP, Leffler DA. Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. Gastroenterology. 2009 Aug; 137(2):445-52. PMID: 19410575.
    Citations: 45     Fields:    Translation:Humans
  181. Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Jamma S, Kelly CP. Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther. 2009 Apr 15; 29(8):898-905. PMID: 19183153.
    Citations: 20     Fields:    Translation:Humans
  182. Edwards George JB, Leffler DA, Dennis MD, Franko DL, Blom-Hoffman J, Kelly CP. Psychological correlates of gluten-free diet adherence in adults with celiac disease. J Clin Gastroenterol. 2009 Apr; 43(4):301-6. PMID: 18580599.
    Citations: 10     Fields:    Translation:Humans
  183. Leffler DA, Dennis M, Edwards George JB, Jamma S, Magge S, Cook EF, Schuppan D, Kelly CP. A simple validated gluten-free diet adherence survey for adults with celiac disease. Clin Gastroenterol Hepatol. 2009 May; 7(5):530-6, 536.e1-2. PMID: 19268725.
    Citations: 82     Fields:    Translation:Humans
  184. Hu MY, Katchar K, Kyne L, Maroo S, Tummala S, Dreisbach V, Xu H, Leffler DA, Kelly CP. Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection. Gastroenterology. 2009 Apr; 136(4):1206-14. PMID: 19162027.
    Citations: 87     Fields:    Translation:HumansCellsPHPublic Health
  185. Shields HM, Leffler DA, White AA, Hafler JP, Pelletier SR, O'farrell RP, Llerena-Quinn R, Hayward JN, Salamone S, Lenco AM, Blanco PG, Peters AS. Integration of racial, cultural, ethnic, and socioeconomic factors into a gastrointestinal pathophysiology course. Clin Gastroenterol Hepatol. 2009 Mar; 7(3):279-84. PMID: 19118643.
    Citations:    Fields:    Translation:Humans
  186. Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL, Blom-Hoffman J, Kelly CP. Factors that influence adherence to a gluten-free diet in adults with celiac disease. Dig Dis Sci. 2008 Jun; 53(6):1573-81. PMID: 17990115.
    Citations: 48     Fields:    Translation:Humans
  187. Leffler D, Cheifetz A, Chiefetz A. Forecasting the recurrence of ulcerative colitis: can U.C. the future? Inflamm Bowel Dis. 2008 Mar; 14(3):422-4. PMID: 17973306.
    Citations: 1     Fields:    Translation:Humans
  188. Leffler DA, Edwards George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease. Aliment Pharmacol Ther. 2007 Nov 01; 26(9):1227-35. PMID: 17944737.
    Citations: 38     Fields:    Translation:Humans
  189. Abdallah H, Leffler D, Dennis M, Kelly CP. Refractory celiac disease. Curr Gastroenterol Rep. 2007 Oct; 9(5):401-5. PMID: 17991341.
    Citations: 11     Fields:    Translation:Humans
  190. Gill BM, Leffler DA. Celiac disease: diagnosis, autoimmune mechanisms and treatment. Expert Rev Clin Immunol. 2007 Sep; 3(5):763-72. PMID: 20477026.
    Citations:    Fields:    
  191. Shields HM, Guss D, Somers SC, Kerfoot BP, Mandell BS, Travassos WJ, Ullman SM, Maroo S, Honan JP, Raymond LW, Goldberg EM, Leffler DA, Hayward JN, Pelletier SR, Carbo AR, Fishman LN, Nath BJ, Cohn MA, Hafler JP. A faculty development program to train tutors to be discussion leaders rather than facilitators. Acad Med. 2007 May; 82(5):486-92. PMID: 17457073.
    Citations: 9     Fields:    Translation:Humans