Harvard Catalyst Profiles

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Mara Lorenzi, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21EY024108 (LORENZI, MARA) Aug 1, 2014 - Jul 31, 2016
    NIH
    Protection and Repair of Retinal Microvessels
    Role: Principal Investigator
  2. R01EY017637 (LORENZI, MARA) Jan 1, 2009 - Dec 31, 2013
    NIH
    Mechanisms of action of drugs that prevent experimental diabetic retinopathy
    Role: Co-Principal Investigator
  3. R01EY014812 (LORENZI, MARA) Sep 30, 2002 - Aug 31, 2006
    NIH
    Retinal Blood Flow and Microthrombi in Type 1 Diabetes
    Role: Principal Investigator
  4. R01EY009122 (LORENZI, MARA) Aug 1, 1987 - Jul 31, 2004
    NIH
    HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Role: Principal Investigator
  5. R01HL036861 (LORENZI, MARA) Aug 1, 1987 - Jul 31, 1990
    NIH
    HIGH GLUCOSE, DNA, AND DIABETIC COMPLICATIONS
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tecilazich F, Phan TA, Simeoni F, Scotti GM, Dagher Z, Lorenzi M. Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels. Diabetes. 2020 12; 69(12):2709-2719. PMID: 32907815; PMCID: PMC7679768.
    Citations: 3     Fields:    Translation:AnimalsCells
  2. Dagher Z, Gerhardinger C, Vaz J, Goodridge M, Tecilazich F, Lorenzi M. The Increased Transforming Growth Factor-ß Signaling Induced by Diabetes Protects Retinal Vessels. Am J Pathol. 2017 Mar; 187(3):627-638. PMID: 28162229; PMCID: PMC5397667.
    Citations: 11     Fields:    Translation:AnimalsCells
  3. Tecilazich F, Feke GT, Mazzantini S, Sobrin L, Lorenzi M. Defective Myogenic Response of Retinal Vessels Is Associated With Accelerated Onset of Retinopathy in Type 1 Diabetic Individuals. Invest Ophthalmol Vis Sci. 2016 Apr; 57(4):1523-9. PMID: 27035625.
    Citations: 7     Fields:    Translation:Humans
  4. Scotti F, Maestroni A, Palini A, Introini U, Setaccioli M, Lorenzi M, Zerbini G. Endothelial progenitor cells and response to ranibizumab in age-related macular degeneration. Retina. 2014 Sep; 34(9):1802-10. PMID: 24736462.
    Citations: 3     Fields:    Translation:HumansCells
  5. Zerbini G, Maestroni A, Palini A, Tremolada G, Lattanzio R, Maestroni S, Pastore MR, Secchi A, Bonfanti R, Gerhardinger C, Lorenzi M. Endothelial progenitor cells carrying monocyte markers are selectively abnormal in type 1 diabetic patients with early retinopathy. Diabetes. 2012 Apr; 61(4):908-14. PMID: 22338095; PMCID: PMC3314367.
    Citations: 9     Fields:    Translation:HumansCells
  6. Tremolada G, Pierro L, de Benedetto U, Margari S, Gagliardi M, Maestranzi G, Calori G, Lorenzi M, Lattanzio R. Macular micropseudocysts in early stages of diabetic retinopathy. Retina. 2011 Jul-Aug; 31(7):1352-8. PMID: 21394067.
    Citations:    Fields:    Translation:Humans
  7. Lorenzi M, Feke GT, Pitler L, Berisha F, Kolodjaschna J, McMeel JW. Defective myogenic response to posture change in retinal vessels of well-controlled type 1 diabetic patients with no retinopathy. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6770-5. PMID: 20592228.
    Citations: 11     Fields:    Translation:Humans
  8. Gerhardinger C, Dagher Z, Sebastiani P, Park YS, Lorenzi M. The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Diabetes. 2009 Jul; 58(7):1659-67. PMID: 19401417; PMCID: PMC2699853.
    Citations: 33     Fields:    Translation:Animals
  9. Zerbini G, Lorenzi M, Palini A. Tumor angiogenesis. N Engl J Med. 2008 Aug 14; 359(7):763; author reply 764. PMID: 18703484.
    Citations: 13     Fields:    Translation:HumansCells
  10. Lorenzi M, Feke GT, Cagliero E, Pitler L, Schaumberg DA, Berisha F, Nathan DM, McMeel JW. Retinal haemodynamics in individuals with well-controlled type 1 diabetes. Diabetologia. 2008 Feb; 51(2):361-4. PMID: 18026927.
    Citations: 21     Fields:    Translation:Humans
  11. Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res. 2007; 2007:61038. PMID: 18224243.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  12. Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes. 2006 Oct; 55(10):2757-62. PMID: 17003340.
    Citations: 32     Fields:    Translation:AnimalsCells
  13. Lorenzi M. Mechanisms and strategies for prevention in diabetic retinopathy. Curr Diab Rep. 2006 Apr; 6(2):102-7. PMID: 16542619.
    Citations: 4     Fields:    Translation:HumansAnimals
  14. Sun W, Gerhardinger C, Dagher Z, Hoehn T, Lorenzi M. Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects. Diabetes. 2005 Dec; 54(12):3418-26. PMID: 16306357.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M. Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes. 2004 Sep; 53(9):2404-11. PMID: 15331552.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  16. Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M. A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes. 2003 Feb; 52(2):506-11. PMID: 12540628.
    Citations: 100     Fields:    Translation:AnimalsCells
  17. Zhang J, Gerhardinger C, Lorenzi M. Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. Diabetes. 2002 Dec; 51(12):3499-504. PMID: 12453906.
    Citations: 61     Fields:    Translation:HumansAnimals
  18. Romeo G, Liu WH, Asnaghi V, Kern TS, Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes. 2002 Jul; 51(7):2241-8. PMID: 12086956.
    Citations: 147     Fields:    Translation:HumansCells
  19. Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV. Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene. 2001 Nov 29; 20(55):7965-75. PMID: 11753679.
    Citations: 33     Fields:    Translation:HumansCells
  20. Lorenzi M, Gerhardinger C. Early cellular and molecular changes induced by diabetes in the retina. Diabetologia. 2001 Jul; 44(7):791-804. PMID: 11508263.
    Citations: 66     Fields:    Translation:HumansAnimals
  21. Boeri D, Maiello M, Lorenzi M. Increased prevalence of microthromboses in retinal capillaries of diabetic individuals. Diabetes. 2001 Jun; 50(6):1432-9. PMID: 11375345.
    Citations: 36     Fields:    Translation:Humans
  22. Gerhardinger C, McClure KD, Romeo G, Podestà F, Lorenzi M. IGF-I mRNA and signaling in the diabetic retina. Diabetes. 2001 Jan; 50(1):175-83. PMID: 11147784.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  23. Kern TS, Tang J, Mizutani M, Kowluru RA, Nagaraj RH, Romeo G, Podesta F, Lorenzi M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3972-8. PMID: 11053301.
    Citations: 113     Fields:    Translation:AnimalsCells
  24. Podestà F, Romeo G, Liu WH, Krajewski S, Reed JC, Gerhardinger C, Lorenzi M. Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro. Am J Pathol. 2000 Mar; 156(3):1025-32. PMID: 10702418; PMCID: PMC1876844.
    Citations: 59     Fields:    Translation:HumansCells
  25. Gerhardinger C, Brown LF, Roy S, Mizutani M, Zucker CL, Lorenzi M. Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy. Am J Pathol. 1998 Jun; 152(6):1453-62. PMID: 9626050; PMCID: PMC1858432.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  26. Mizutani M, Gerhardinger C, Lorenzi M. Müller cell changes in human diabetic retinopathy. Diabetes. 1998 Mar; 47(3):445-9. PMID: 9519752.
    Citations: 174     Fields:    Translation:HumansAnimals
  27. Lopes de Faria JB, Zoukhri D, Lorenzi M. Mesangial cell abnormalities in spontaneously hypertensive rats before the onset of hypertension. Kidney Int. 1997 Aug; 52(2):387-92. PMID: 9263994.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Podestá F, Roth T, Ferrara F, Cagliero E, Lorenzi M. Cytoskeletal changes induced by excess extracellular matrix impair endothelial cell replication. Diabetologia. 1997 Aug; 40(8):879-86. PMID: 9267981.
    Citations: 5     Fields:    Translation:HumansCells
  29. Mizutani M, Kern TS, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest. 1996 Jun 15; 97(12):2883-90. PMID: 8675702; PMCID: PMC507384.
    Citations: 256     Fields:    Translation:HumansAnimals
  30. Roy S, Lorenzi M. Early biosynthetic changes in the diabetic-like retinopathy of galactose-fed rats. Diabetologia. 1996 Jun; 39(6):735-8. PMID: 8781771.
    Citations: 13     Fields:    Translation:Animals
  31. Roy S, Cagliero E, Lorenzi M. Fibronectin overexpression in retinal microvessels of patients with diabetes. Invest Ophthalmol Vis Sci. 1996 Feb; 37(2):258-66. PMID: 8603829.
    Citations: 42     Fields:    Translation:HumansCells
  32. Cagliero E, Roth T, Taylor AW, Lorenzi M. The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming growth factor-beta. Lab Invest. 1995 Nov; 73(5):667-73. PMID: 7474940.
    Citations: 4     Fields:    Translation:HumansCells
  33. Zerbini G, Roth T, Podestá F, Cagliero E, Doria A, Canessa M, Lorenzi M. Activity and expression of the Na+/H+ exchanger in human endothelial cells cultured in high glucose. Diabetologia. 1995 Jul; 38(7):785-91. PMID: 7556979.
    Citations: 4     Fields:    Translation:HumansCells
  34. Boeri D, Cagliero E, Podestá F, Lorenzi M. Vascular wall von Willebrand factor in human diabetic retinopathy. Invest Ophthalmol Vis Sci. 1994 Feb; 35(2):600-7. PMID: 8113010.
    Citations: 6     Fields:    Translation:Humans
  35. Roy S, Maiello M, Lorenzi M. Increased expression of basement membrane collagen in human diabetic retinopathy. J Clin Invest. 1994 Jan; 93(1):438-42. PMID: 8282817; PMCID: PMC293808.
    Citations: 39     Fields:    Translation:HumansCells
  36. Roth T, Podestá F, Stepp MA, Boeri D, Lorenzi M. Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9640-4. PMID: 8415754; PMCID: PMC47625.
    Citations: 30     Fields:    Translation:HumansCells
  37. Cagliero E, Forsberg H, Sala R, Lorenzi M, Eriksson UJ. Maternal diabetes induces increased expression of extracellular matrix components in rat embryos. Diabetes. 1993 Jul; 42(7):975-80. PMID: 7685721.
    Citations: 11     Fields:    Translation:AnimalsCells
  38. Lorenzi MV, Trinidad AC, Zhang R, Strauss WL. Two mRNAs are transcribed from the human gene for choline acetyltransferase. DNA Cell Biol. 1992 Oct; 11(8):593-603. PMID: 1388731.
    Citations: 1     Fields:    Translation:HumansCells
  39. Lorenzi M. Glucose toxicity in the vascular complications of diabetes: the cellular perspective. Diabetes Metab Rev. 1992 Jul; 8(2):85-103. PMID: 1425126.
    Citations: 13     Fields:    Translation:Humans
  40. Lorenzi MV, Knusel B, Hefti F, Strauss WL. Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures. Neurosci Lett. 1992 Jun 22; 140(2):185-8. PMID: 1380145.
    Citations: 2     Fields:    Translation:Animals
  41. Cagliero E, Roth T, Roy S, Maiello M, Lorenzi M. Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP. J Biol Chem. 1991 Aug 05; 266(22):14244-50. PMID: 1713580.
    Citations: 13     Fields:    Translation:HumansCells
  42. Cagliero E, Grant MB, Lorenzi M. Measurement of gene expression in human retinal microvessels by solution hybridization. Invest Ophthalmol Vis Sci. 1991 Apr; 32(5):1439-45. PMID: 1707859.
    Citations: 2     Fields:    Translation:HumansCells
  43. Cagliero E, Roth T, Roy S, Lorenzi M. Characteristics and mechanisms of high-glucose-induced overexpression of basement membrane components in cultured human endothelial cells. Diabetes. 1991 Jan; 40(1):102-10. PMID: 2015965.
    Citations: 30     Fields:    Translation:HumansCells
  44. Lorenzi M. The blood-brain barrier in diabetes mellitus. Adv Exp Med Biol. 1990; 274:381-90. PMID: 2239434.
    Citations:    Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.