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profileJack William Lawler, Ph.D.

TitleProfessor of Pathology
InstitutionBeth Israel Deaconess Medical Center
DepartmentPathology
AddressBeth Israel Deaconess Med Ctr
Rn 270k
99 Brookline Ave
Boston MA 02215
Phone617/667-1694
Fax617/667-3591
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Desai P, Helkin A, Odugbesi A, Stein J, Bruch D, Lawler J, Maier KG, Gahtan V. Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice. J Surg Res. 2017 Apr; 210:1-7. PMID: 28457315.
    View in: PubMed
  2. Lawler J. When is a thrombogenic matrix not thrombogenic? Blood. 2016 Sep 22; 128(12):1543-4. PMID: 27658700.
    View in: PubMed
  3. Lopez-Dee ZP, Chittur SV, Patel H, Chinikaylo A, Lippert B, Patel B, Lawler J, Gutierrez LS. Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis. PLoS One. 2015; 10(10):e0139918. PMID: 26461935; PMCID: PMC4603676.
    View in: PubMed, PubMed Central
  4. Sims JN, Lawler J. Thrombospondin-1-Based Antiangiogenic Therapy. J Ocul Pharmacol Ther. 2015 Sep; 31(7):366-70. PMID: 26352160; PMCID: PMC4696437.
    View in: PubMed, PubMed Central
  5. Russell S, Duquette M, Liu J, Drapkin R, Lawler J, Petrik J. Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer. FASEB J. 2015 Feb; 29(2):576-88. PMID: 25395453; PMCID: PMC4314231.
    View in: PubMed, PubMed Central
  6. Choi SH, Tamura K, Khajuria RK, Bhere D, Nesterenko I, Lawler J, Shah K. Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas. Mol Ther. 2015 Feb; 23(2):235-43. PMID: 25358253; PMCID: PMC4445617 [Available on 02/01/16].
    View in: PubMed, PubMed Central
  7. Ndishabandi D, Duquette C, Billah GE, Reyes M, Duquette M, Lawler J, Kazerounian S. Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro. Discoveries (Craiova). 2014 Oct-Dec; 2(4). PMID: 26273699.
    View in: PubMed
  8. Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C. Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 25063326; PMCID: PMC4155429.
    View in: PubMed, PubMed Central
  9. Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biol. 2014 Jul; 37:15-24. PMID: 24845346; PMCID: PMC4502920.
    View in: PubMed, PubMed Central
  10. Dews M, Tan GS, Hultine S, Raman P, Choi J, Duperret EK, Lawler J, Bass A, Thomas-Tikhonenko A. Masking epistasis between MYC and TGF-ß pathways in antiangiogenesis-mediated colon cancer suppression. J Natl Cancer Inst. 2014 Apr; 106(4):dju043. PMID: 24627270; PMCID: PMC3982891.
    View in: PubMed, PubMed Central
  11. Duquette M, Sadow PM, Lawler J, Nucera C. Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment. Front Endocrinol (Lausanne). 2013; 4:189. PMID: 24348463; PMCID: PMC3845490.
    View in: PubMed, PubMed Central
  12. Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64. PMID: 23315169; PMCID: PMC3596973.
    View in: PubMed, PubMed Central
  13. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. PMID: 22808206; PMCID: PMC3394756.
    View in: PubMed, PubMed Central
  14. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(ß-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 02; 209(7):1289-307. PMID: 22711876; PMCID: PMC3405505.
    View in: PubMed, PubMed Central
  15. Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012 Jun 08; 149(6):1257-68. PMID: 22682248; PMCID: PMC3372931.
    View in: PubMed, PubMed Central
  16. Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May; 2(5):a006627. PMID: 22553494; PMCID: PMC3331684.
    View in: PubMed, PubMed Central
  17. Adams JC, Lawler J. The thrombospondins. Cold Spring Harb Perspect Biol. 2011 Oct 01; 3(10):a009712. PMID: 21875984; PMCID: PMC3179333.
    View in: PubMed, PubMed Central
  18. Seymour KA, Sadowitz B, Stein JJ, Lawler J, Maier KG, Gahtan V. Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. Am J Surg. 2011 Nov; 202(5):553-7. PMID: 21906719.
    View in: PubMed
  19. Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9939-44. PMID: 21622854; PMCID: PMC3116421.
    View in: PubMed, PubMed Central
  20. Olerud J, Mokhtari D, Johansson M, Christoffersson G, Lawler J, Welsh N, Carlsson PO. Thrombospondin-1: an islet endothelial cell signal of importance for ß-cell function. Diabetes. 2011 Jul; 60(7):1946-54. PMID: 21617177; PMCID: PMC3121439.
    View in: PubMed, PubMed Central
  21. Tan K, Lawler J. The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein. BMC Struct Biol. 2011 May 10; 11:22. PMID: 21569239; PMCID: PMC3117680.
    View in: PubMed, PubMed Central
  22. Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. 2011 May 09; 208(5):1083-92. PMID: 21536744; PMCID: PMC3092349.
    View in: PubMed, PubMed Central
  23. Nucera C, Lawler J, Parangi S. BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res. 2011 Apr 01; 71(7):2417-22. PMID: 21447745; PMCID: PMC3913061.
    View in: PubMed, PubMed Central
  24. Kazerounian S, Duquette M, Reyes MA, Lawler JT, Song K, Perruzzi C, Primo L, Khosravi-Far R, Bussolino F, Rabinovitz I, Lawler J. Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase. Blood. 2011 Apr 28; 117(17):4658-66. PMID: 21378271; PMCID: PMC3099580.
    View in: PubMed, PubMed Central
  25. Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011; 16(3):296-309. PMID: 21355020; PMCID: PMC3073446.
    View in: PubMed, PubMed Central
  26. Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010 Dec; 1(8):751-6. PMID: 21321384; PMCID: PMC3074562.
    View in: PubMed, PubMed Central
  27. Ezzie ME, Piper MG, Montague C, Newland CA, Opalek JM, Baran C, Ali N, Brigstock D, Lawler J, Marsh CB. Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):556-61. PMID: 20581099; PMCID: PMC3095927.
    View in: PubMed, PubMed Central
  28. Lawler J. Megakaryocytes join the war on cancer. Blood. 2010 Jun 03; 115(22):4326-7. PMID: 20522719.
    View in: PubMed
  29. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10649-54. PMID: 20498063; PMCID: PMC2890809.
    View in: PubMed, PubMed Central
  30. Tan K, Lawler J. The interaction of Thrombospondins with extracellular matrix proteins. J Cell Commun Signal. 2009 Dec; 3(3-4):177-87. PMID: 19830595.
    View in: PubMed
  31. Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009 Oct 16; 139(2):380-92. PMID: 19818485; PMCID: PMC2791798.
    View in: PubMed, PubMed Central
  32. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid. 2009 Oct; 19(10):1077-84. PMID: 19772429; PMCID: PMC2833178.
    View in: PubMed, PubMed Central
  33. Lawler J. Introduction to the tumour microenvironment review series. J Cell Mol Med. 2009 Aug; 13(8A):1403-4. PMID: 19583804; PMCID: PMC3073444.
    View in: PubMed, PubMed Central
  34. Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J. Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct; 23(10):3368-76. PMID: 19528255; PMCID: PMC2747678.
    View in: PubMed, PubMed Central
  35. Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res. 2009 May 01; 69(9):3856-65. PMID: 19366809; PMCID: PMC2981788.
    View in: PubMed, PubMed Central
  36. Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1344-51. PMID: 19304944; PMCID: PMC2685346.
    View in: PubMed, PubMed Central
  37. Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009 Aug; 23(8):2490-501. PMID: 19276170; PMCID: PMC2717772.
    View in: PubMed, PubMed Central
  38. Velasco P, Huegel R, Brasch J, Schröder JM, Weichenthal M, Stockfleth E, Schwarz T, Lawler J, Detmar M, Lange-Asschenfeldt B. The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol. 2009 Aug; 129(8):2022-30. PMID: 19194474.
    View in: PubMed
  39. Greenaway J, Henkin J, Lawler J, Moorehead R, Petrik J. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan; 8(1):64-74. PMID: 19139114; PMCID: PMC3383797.
    View in: PubMed, PubMed Central
  40. Tan K, Duquette M, Liu JH, Lawler J, Wang JH. The crystal structure of the heparin-binding reelin-N domain of f-spondin. J Mol Biol. 2008 Sep 19; 381(5):1213-23. PMID: 18602404; PMCID: PMC2561254.
    View in: PubMed, PubMed Central
  41. Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT. Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Am J Pathol. 2008 Jun; 172(6):1664-74. PMID: 18467703; PMCID: PMC2408425.
    View in: PubMed, PubMed Central
  42. Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes. 2008 Jul; 57(7):1870-7. PMID: 18420490; PMCID: PMC2453615.
    View in: PubMed, PubMed Central
  43. Yee KO, Connolly CM, Duquette M, Kazerounian S, Washington R, Lawler J. The effect of thrombospondin-1 on breast cancer metastasis. Breast Cancer Res Treat. 2009 Mar; 114(1):85-96. PMID: 18409060; PMCID: PMC2631620.
    View in: PubMed, PubMed Central
  44. Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008; 75(1):9-21. PMID: 18334835.
    View in: PubMed
  45. Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Sci. 2008 Mar; 65(5):700-12. PMID: 18193162; PMCID: PMC2752021.
    View in: PubMed, PubMed Central
  46. Tan K, Duquette M, Liu JH, Shanmugasundaram K, Joachimiak A, Gallagher JT, Rigby AC, Wang JH, Lawler J. Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain. J Biol Chem. 2008 Feb 15; 283(7):3932-41. PMID: 18065761; PMCID: PMC2918642.
    View in: PubMed, PubMed Central
  47. Daniel C, Schaub K, Amann K, Lawler J, Hugo C. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo. Diabetes. 2007 Dec; 56(12):2982-9. PMID: 17878288.
    View in: PubMed
  48. Zhang X, Xu J, Lawler J, Terwilliger E, Parangi S. Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. Clin Cancer Res. 2007 Jul 01; 13(13):3968-76. PMID: 17606731.
    View in: PubMed
  49. Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J. Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 2007 Aug 24; 282(34):24591-8. PMID: 17588949; PMCID: PMC2905148.
    View in: PubMed, PubMed Central
  50. Budhani F, Leonard KA, Bergdahl A, Gao J, Lawler J, Davis EC. Vascular response to intra-arterial injury in the thrombospondin-1 null mouse. J Mol Cell Cardiol. 2007 Aug; 43(2):210-4. PMID: 17583726; PMCID: PMC2045697.
    View in: PubMed, PubMed Central
  51. Zhang X, Lawler J. Thrombospondin-based antiangiogenic therapy. Microvasc Res. 2007 Sep-Nov; 74(2-3):90-9. PMID: 17559888; PMCID: PMC2100421.
    View in: PubMed, PubMed Central
  52. Greenaway J, Lawler J, Moorehead R, Bornstein P, Lamarre J, Petrik J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol. 2007 Mar; 210(3):807-18. PMID: 17154366; PMCID: PMC3412056.
    View in: PubMed, PubMed Central
  53. Zhang X, Connolly C, Duquette M, Lawler J, Parangi S. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Cancer Lett. 2007 Mar 08; 247(1):143-9. PMID: 16757110; PMCID: PMC3205930.
    View in: PubMed, PubMed Central
  54. Zwicker JI, Peyvandi F, Palla R, Lombardi R, Canciani MT, Cairo A, Ardissino D, Bernardinelli L, Bauer KA, Lawler J, Mannucci P. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. Blood. 2006 Aug 15; 108(4):1280-3. PMID: 16684956; PMCID: PMC1895875.
    View in: PubMed, PubMed Central
  55. Yee KO, Connolly CM, Pines M, Lawler J. Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism. Cancer Biol Ther. 2006 Feb; 5(2):218-24. PMID: 16418571.
    View in: PubMed
  56. Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan; 14(1):33-42. PMID: 16407063; PMCID: PMC2896259.
    View in: PubMed, PubMed Central
  57. Ren B, Yee KO, Lawler J, Khosravi-Far R. Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 2006 Apr; 1765(2):178-88. PMID: 16406676.
    View in: PubMed
  58. Bonnefoy A, Daenens K, Feys HB, De Vos R, Vandervoort P, Vermylen J, Lawler J, Hoylaerts MF. Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Blood. 2006 Feb 01; 107(3):955-64. PMID: 16204318; PMCID: PMC1895898.
    View in: PubMed, PubMed Central
  59. Zhang X, Galardi E, Duquette M, Lawler J, Parangi S. Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Aug 01; 11(15):5622-30. PMID: 16061881.
    View in: PubMed
  60. Chen FH, Thomas AO, Hecht JT, Goldring MB, Lawler J. Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem. 2005 Sep 23; 280(38):32655-61. PMID: 16051604; PMCID: PMC2896261.
    View in: PubMed, PubMed Central
  61. Frangogiannis NG, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, Winkelmann K, Michael LH, Lawler J, Entman ML. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005 Jun 07; 111(22):2935-42. PMID: 15927970.
    View in: PubMed
  62. Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005 Apr-Jun; 9(2):421-37. PMID: 15963261.
    View in: PubMed
  63. Saumet A, Slimane MB, Lanotte M, Lawler J, Dubernard V. Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells. Blood. 2005 Jul 15; 106(2):658-67. PMID: 15784731.
    View in: PubMed
  64. Isenberg JS, Calzada MJ, Zhou L, Guo N, Lawler J, Wang XQ, Frazier WA, Roberts DD. Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Matrix Biol. 2005 Apr; 24(2):110-23. PMID: 15890262.
    View in: PubMed
  65. Zhang X, Galardi E, Duquette M, Delic M, Lawler J, Parangi S. Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Mar 15; 11(6):2337-44. PMID: 15788685.
    View in: PubMed
  66. Sund M, Hamano Y, Sugimoto H, Sudhakar A, Soubasakos M, Yerramalla U, Benjamin LE, Lawler J, Kieran M, Shah A, Kalluri R. Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2934-9. PMID: 15710885; PMCID: PMC549486.
    View in: PubMed, PubMed Central
  67. Short SM, Derrien A, Narsimhan RP, Lawler J, Ingber DE, Zetter BR. Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol. 2005 Feb 14; 168(4):643-53. PMID: 15716381; PMCID: PMC2171765.
    View in: PubMed, PubMed Central
  68. Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005 Feb 11; 120(3):421-33. PMID: 15707899.
    View in: PubMed
  69. Shaked Y, Bertolini F, Man S, Rogers MS, Cervi D, Foutz T, Rawn K, Voskas D, Dumont DJ, Ben-David Y, Lawler J, Henkin J, Huber J, Hicklin DJ, D'Amato RJ, Kerbel RS. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell. 2005 Jan; 7(1):101-11. PMID: 15652753.
    View in: PubMed
  70. Nör JE, Dipietro L, Murphy-Ullrich JE, Hynes RO, Lawler J, Polverini PJ. Activation of Latent TGF-ß1 by Thrombospondin-1 is a Major Component of Wound Repair. Oral Biosci Med. 2005; 2(2):153-161. PMID: 21822445.
    View in: PubMed
  71. Calzada MJ, Annis DS, Zeng B, Marcinkiewicz C, Banas B, Lawler J, Mosher DF, Roberts DD. Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. J Biol Chem. 2004 Oct 01; 279(40):41734-43. PMID: 15292271.
    View in: PubMed
  72. Yee KO, Streit M, Hawighorst T, Detmar M, Lawler J. Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol. 2004 Aug; 165(2):541-52. PMID: 15277228; PMCID: PMC1618557.
    View in: PubMed, PubMed Central
  73. Lawler J, Detmar M. Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol. 2004 Jun; 36(6):1038-45. PMID: 15094119.
    View in: PubMed
  74. Adams JC, Lawler J. The thrombospondins. Int J Biochem Cell Biol. 2004 Jun; 36(6):961-8. PMID: 15094109; PMCID: PMC2885884.
    View in: PubMed, PubMed Central
  75. Niu Q, Perruzzi C, Voskas D, Lawler J, Dumont DJ, Benjamin LE. Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer Biol Ther. 2004 Apr; 3(4):402-5. PMID: 14739779.
    View in: PubMed
  76. Cursiefen C, Masli S, Ng TF, Dana MR, Bornstein P, Lawler J, Streilein JW. Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci. 2004 Apr; 45(4):1117-24. PMID: 15037577.
    View in: PubMed
  77. Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, Sudhakar A, Kalluri R. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 2004 Mar 01; 64(5):1570-4. PMID: 14996710.
    View in: PubMed
  78. Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, Argraves WS, Liau G. Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans. J Cell Biochem. 2004 Mar 01; 91(4):766-76. PMID: 14991768.
    View in: PubMed
  79. Pimanda JE, Ganderton T, Maekawa A, Yap CL, Lawler J, Kershaw G, Chesterman CN, Hogg PJ. Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice. J Biol Chem. 2004 May 14; 279(20):21439-48. PMID: 14981081.
    View in: PubMed
  80. Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas TN, Rosenkranz AR. Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis. Nephron Exp Nephrol. 2004; 96(2):e31-8. PMID: 14988590.
    View in: PubMed
  81. Wang S, Wu Z, Sorenson CM, Lawler J, Sheibani N. Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration. Dev Dyn. 2003 Dec; 228(4):630-42. PMID: 14648840.
    View in: PubMed
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  92. Miao WM, Seng WL, Duquette M, Lawler P, Laus C, Lawler J. Thrombospondin-1 type 1 repeat recombinant proteins inhibit tumor growth through transforming growth factor-beta-dependent and -independent mechanisms. Cancer Res. 2001 Nov 01; 61(21):7830-9. PMID: 11691800.
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  105. Sipes JM, Krutzsch HC, Lawler J, Roberts DD. Cooperation between thrombospondin-1 type 1 repeat peptides and alpha(v)beta(3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation. J Biol Chem. 1999 Aug 06; 274(32):22755-62. PMID: 10428859.
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  107. Eda S, Lawler J, Sherman IW. Plasmodium falciparum-infected erythrocyte adhesion to the type 3 repeat domain of thrombospondin-1 is mediated by a modified band 3 protein. Mol Biochem Parasitol. 1999 May 25; 100(2):195-205. PMID: 10391381.
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  113. Guo N, Zabrenetzky VS, Chandrasekaran L, Sipes JM, Lawler J, Krutzsch HC, Roberts DD. Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. Cancer Res. 1998 Jul 15; 58(14):3154-62. PMID: 9679984.
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  182. Lawler JW, Slayter HS. The release of heparin binding peptides from platelet thrombospondin by proteolytic action of thrombin, plasmin and trypsin. Thromb Res. 1981 May 01; 22(3):267-79. PMID: 6458114.
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  183. Lawler JW. Prediction of the secondary structure of platelet factor 4 and beta-thromboglobulin from their amino acid sequences. Thromb Res. 1981 Jan 1-15; 21(1-2):121-7. PMID: 6165091.
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  184. Lawler JW, Chao FC, Fang PH. The effect of ultraviolet light on platelets: platelet activation and inhibition of thrombin-mediated functions. Thromb Res. 1979 Feb-Mar; 14(2-3):489-94. PMID: 442018.
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  185. Lawler JW, Slayter HS, Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem. 1978 Dec 10; 253(23):8609-16. PMID: 101549.
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  186. Lawler JW, Chao FC, Fang PH. Observation of a high molecular weight platelet protein released by thrombin. Thromb Haemost. 1977 Apr 30; 37(2):355-7. PMID: 577633.
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  187. Chao FC, Tullis JL, Conneely GS, Lawler JW. Aggregation of platelets and inert particles induced by thrombin. Thromb Haemost. 1976 Jun 30; 35(3):717-36. PMID: 10638.
    View in: PubMed
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