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Jack William Lawler, Ph.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Matuszewska K, Ten Kortenaar S, Pereira M, Santry LA, Petrik D, Lo KM, Bridle BW, Wootton SK, Lawler J, Petrik J. Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer. Gynecol Oncol. 2022 01; 164(1):154-169. PMID: 34799137.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Morandi V, Petrik J, Lawler J. Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1. Front Cell Dev Biol. 2021; 9:664696. PMID: 33869231.
    Citations: 1     
  3. Duquette M, Sadow PM, Lawler J, Nucera C. Corrigendum: Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells With BRAFV600E: New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment. Front Endocrinol (Lausanne). 2020; 11:596223. PMID: 33162943.
    Citations:    Fields:    
  4. Yu DL, Stegelmeier AA, Chow N, Rghei AD, Matuszewska K, Lawler J, Bridle BW, Petrik JJ, Wootton SK. AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma. Cancer Gene Ther. 2020 05; 27(5):356-367. PMID: 31160686.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Matuszewska K, Santry LA, van Vloten JP, AuYeung AWK, Major PP, Lawler J, Wootton SK, Bridle BW, Petrik J. Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer. Clin Cancer Res. 2019 03 01; 25(5):1624-1638. PMID: 30206160.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  6. Prete A, Lo AS, Sadow PM, Bhasin SS, Antonello ZA, Vodopivec DM, Ullas S, Sims JN, Clohessy J, Dvorak AM, Sciuto T, Bhasin M, Murphy-Ullrich JE, Lawler J, Karumanchi SA, Nucera C. Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFß1 Axis. Clin Cancer Res. 2018 12 01; 24(23):6078-6097. PMID: 30076136.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  7. Kazerounian S, Lawler J. Integration of pro- and anti-angiogenic signals by endothelial cells. J Cell Commun Signal. 2018 Mar; 12(1):171-179. PMID: 29264709.
    Citations: 20     
  8. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. PMID: 28970240.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  9. Desai P, Helkin A, Odugbesi A, Stein J, Bruch D, Lawler J, Maier KG, Gahtan V. Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice. J Surg Res. 2017 04; 210:1-7. PMID: 28457315.
    Citations: 2     Fields:    Translation:Animals
  10. Lawler J. When is a thrombogenic matrix not thrombogenic? Blood. 2016 09 22; 128(12):1543-4. PMID: 27658700.
    Citations:    Fields:    Translation:Humans
  11. Lopez-Dee ZP, Chittur SV, Patel H, Chinikaylo A, Lippert B, Patel B, Lawler J, Gutierrez LS. Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis. PLoS One. 2015; 10(10):e0139918. PMID: 26461935.
    Citations: 8     Fields:    Translation:AnimalsCells
  12. Sims JN, Lawler J. Thrombospondin-1-Based Antiangiogenic Therapy. J Ocul Pharmacol Ther. 2015 Sep; 31(7):366-70. PMID: 26352160.
    Citations: 5     Fields:    Translation:Humans
  13. Russell S, Duquette M, Liu J, Drapkin R, Lawler J, Petrik J. Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer. FASEB J. 2015 Feb; 29(2):576-88. PMID: 25395453.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  14. Choi SH, Tamura K, Khajuria RK, Bhere D, Nesterenko I, Lawler J, Shah K. Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas. Mol Ther. 2015 Feb; 23(2):235-43. PMID: 25358253.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  15. Ndishabandi D, Duquette C, Billah GE, Reyes M, Duquette M, Lawler J, Kazerounian S. Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro. Discoveries (Craiova). 2014 Oct-Dec; 2(4). PMID: 26273699.
    Citations: 5     
  16. Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C. Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 25063326.
    Citations: 12     Fields:    Translation:HumansCells
  17. Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biol. 2014 Jul; 37:15-24. PMID: 24845346.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Dews M, Tan GS, Hultine S, Raman P, Choi J, Duperret EK, Lawler J, Bass A, Thomas-Tikhonenko A. Masking epistasis between MYC and TGF-ß pathways in antiangiogenesis-mediated colon cancer suppression. J Natl Cancer Inst. 2014 Apr; 106(4):dju043. PMID: 24627270.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  19. Bucur O, Almasan A, Nikolajczyk BS, Nicolson GL, Lawler J, Velculescu VE, Draghici S, Leabu M, Avram D, Bucur I, Calautti E, Calin GA, Chauhan SC, Ciubotaru M, Constantinescu SN, Datta D, Duda DG, Friedman MT, Galardy PJ, Harris BT, Huarte M, Khalil AM, Marchetti D, Movileanu L, Nat R, Nucera C, Popa-Wagner A, Stancu AL, Zhu S, Liehn EA. Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry. Discoveries (Craiova). 2013 Dec 31; 1(1):e1. PMID: 32309535.
    Citations:    
  20. Duquette M, Sadow PM, Lawler J, Nucera C. Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment. Front Endocrinol (Lausanne). 2013; 4:189. PMID: 24348463.
    Citations: 15     Fields:    
  21. Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64. PMID: 23315169.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  22. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. PMID: 22808206.
    Citations: 14     Fields:    Translation:AnimalsCells
  23. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(ß-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 02; 209(7):1289-307. PMID: 22711876.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  24. Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012 Jun 08; 149(6):1257-68. PMID: 22682248.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  25. Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May; 2(5):a006627. PMID: 22553494.
    Citations: 190     Fields:    Translation:HumansCells
  26. Adams JC, Lawler J. The thrombospondins. Cold Spring Harb Perspect Biol. 2011 Oct 01; 3(10):a009712. PMID: 21875984.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  27. Seymour KA, Sadowitz B, Stein JJ, Lawler J, Maier KG, Gahtan V. Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. Am J Surg. 2011 Nov; 202(5):553-7. PMID: 21906719.
    Citations: 1     Fields:    Translation:HumansCells
  28. Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9939-44. PMID: 21622854.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  29. Olerud J, Mokhtari D, Johansson M, Christoffersson G, Lawler J, Welsh N, Carlsson PO. Thrombospondin-1: an islet endothelial cell signal of importance for ß-cell function. Diabetes. 2011 Jul; 60(7):1946-54. PMID: 21617177.
    Citations: 42     Fields:    Translation:AnimalsCells
  30. Tan K, Lawler J. The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein. BMC Struct Biol. 2011 May 10; 11:22. PMID: 21569239.
    Citations: 6     Fields:    Translation:HumansCells
  31. Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S. Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med. 2011 May 09; 208(5):1083-92. PMID: 21536744.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  32. Nucera C, Lawler J, Parangi S. BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res. 2011 Apr 01; 71(7):2417-22. PMID: 21447745.
    Citations: 44     Fields:    Translation:HumansAnimals
  33. Kazerounian S, Duquette M, Reyes MA, Lawler JT, Song K, Perruzzi C, Primo L, Khosravi-Far R, Bussolino F, Rabinovitz I, Lawler J. Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase. Blood. 2011 Apr 28; 117(17):4658-66. PMID: 21378271.
    Citations: 32     Fields:    Translation:HumansCells
  34. Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011; 16(3):296-309. PMID: 21355020.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  35. Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010 Dec; 1(8):751-6. PMID: 21321384.
    Citations: 21     Fields:    Translation:Humans
  36. Ezzie ME, Piper MG, Montague C, Newland CA, Opalek JM, Baran C, Ali N, Brigstock D, Lawler J, Marsh CB. Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):556-61. PMID: 20581099.
    Citations: 21     Fields:    Translation:AnimalsCells
  37. Lawler J. Megakaryocytes join the war on cancer. Blood. 2010 Jun 03; 115(22):4326-7. PMID: 20522719.
    Citations:    Fields:    
  38. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10649-54. PMID: 20498063.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  39. Tan K, Lawler J. The interaction of Thrombospondins with extracellular matrix proteins. J Cell Commun Signal. 2009 Dec; 3(3-4):177-87. PMID: 19830595.
    Citations: 48     
  40. Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009 Oct 16; 139(2):380-92. PMID: 19818485.
    Citations: 383     Fields:    Translation:AnimalsCells
  41. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid. 2009 Oct; 19(10):1077-84. PMID: 19772429.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  42. Lawler J. Introduction to the tumour microenvironment review series. J Cell Mol Med. 2009 Aug; 13(8A):1403-4. PMID: 19583804.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  43. Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J. Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct; 23(10):3368-76. PMID: 19528255.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  44. Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res. 2009 May 01; 69(9):3856-65. PMID: 19366809.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  45. Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1344-51. PMID: 19304944.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  46. Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009 Aug; 23(8):2490-501. PMID: 19276170.
    Citations: 29     Fields:    Translation:HumansCells
  47. Velasco P, Huegel R, Brasch J, Schröder JM, Weichenthal M, Stockfleth E, Schwarz T, Lawler J, Detmar M, Lange-Asschenfeldt B. The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol. 2009 Aug; 129(8):2022-30. PMID: 19194474.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  48. Greenaway J, Henkin J, Lawler J, Moorehead R, Petrik J. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan; 8(1):64-74. PMID: 19139114.
    Citations: 28     Fields:    Translation:AnimalsCells
  49. Tan K, Duquette M, Liu JH, Lawler J, Wang JH. The crystal structure of the heparin-binding reelin-N domain of f-spondin. J Mol Biol. 2008 Sep 19; 381(5):1213-23. PMID: 18602404.
    Citations: 10     Fields:    Translation:HumansCells
  50. Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT. Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Am J Pathol. 2008 Jun; 172(6):1664-74. PMID: 18467703.
    Citations: 42     Fields:    Translation:Animals
  51. Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes. 2008 Jul; 57(7):1870-7. PMID: 18420490.
    Citations: 32     Fields:    Translation:Animals
  52. Yee KO, Connolly CM, Duquette M, Kazerounian S, Washington R, Lawler J. The effect of thrombospondin-1 on breast cancer metastasis. Breast Cancer Res Treat. 2009 Mar; 114(1):85-96. PMID: 18409060.
    Citations: 60     Fields:    Translation:Animals
  53. Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008; 75(1):9-21. PMID: 18334835.
    Citations: 31     Fields:    Translation:Animals
  54. Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Sci. 2008 Mar; 65(5):700-12. PMID: 18193162.
    Citations: 118     Fields:    Translation:HumansAnimals
  55. Tan K, Duquette M, Liu JH, Shanmugasundaram K, Joachimiak A, Gallagher JT, Rigby AC, Wang JH, Lawler J. Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain. J Biol Chem. 2008 Feb 15; 283(7):3932-41. PMID: 18065761.
    Citations: 20     Fields:    Translation:HumansCells
  56. Daniel C, Schaub K, Amann K, Lawler J, Hugo C. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo. Diabetes. 2007 Dec; 56(12):2982-9. PMID: 17878288.
    Citations: 46     Fields:    Translation:Animals
  57. Zhang X, Xu J, Lawler J, Terwilliger E, Parangi S. Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. Clin Cancer Res. 2007 Jul 01; 13(13):3968-76. PMID: 17606731.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  58. Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J. Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 2007 Aug 24; 282(34):24591-8. PMID: 17588949.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  59. Budhani F, Leonard KA, Bergdahl A, Gao J, Lawler J, Davis EC. Vascular response to intra-arterial injury in the thrombospondin-1 null mouse. J Mol Cell Cardiol. 2007 Aug; 43(2):210-4. PMID: 17583726.
    Citations: 3     Fields:    Translation:Animals
  60. Zhang X, Lawler J. Thrombospondin-based antiangiogenic therapy. Microvasc Res. 2007 Sep-Nov; 74(2-3):90-9. PMID: 17559888.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  61. Greenaway J, Lawler J, Moorehead R, Bornstein P, Lamarre J, Petrik J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol. 2007 Mar; 210(3):807-18. PMID: 17154366.
    Citations: 71     Fields:    Translation:AnimalsCells
  62. Zhang X, Connolly C, Duquette M, Lawler J, Parangi S. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Cancer Lett. 2007 Mar 08; 247(1):143-9. PMID: 16757110.
    Citations: 10     Fields:    Translation:HumansAnimals
  63. Zwicker JI, Peyvandi F, Palla R, Lombardi R, Canciani MT, Cairo A, Ardissino D, Bernardinelli L, Bauer KA, Lawler J, Mannucci P. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. Blood. 2006 Aug 15; 108(4):1280-3. PMID: 16684956.
    Citations: 21     Fields:    Translation:HumansCells
  64. Yee KO, Connolly CM, Pines M, Lawler J. Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism. Cancer Biol Ther. 2006 Feb; 5(2):218-24. PMID: 16418571.
    Citations: 7     Fields:    Translation:AnimalsCells
  65. Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan; 14(1):33-42. PMID: 16407063.
    Citations: 35     Fields:    Translation:HumansCells
  66. Ren B, Yee KO, Lawler J, Khosravi-Far R. Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta. 2006 Apr; 1765(2):178-88. PMID: 16406676.
    Citations: 98     Fields:    Translation:HumansAnimals
  67. Bonnefoy A, Daenens K, Feys HB, De Vos R, Vandervoort P, Vermylen J, Lawler J, Hoylaerts MF. Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Blood. 2006 Feb 01; 107(3):955-64. PMID: 16204318.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  68. Zhang X, Galardi E, Duquette M, Lawler J, Parangi S. Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Aug 01; 11(15):5622-30. PMID: 16061881.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  69. Chen FH, Thomas AO, Hecht JT, Goldring MB, Lawler J. Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem. 2005 Sep 23; 280(38):32655-61. PMID: 16051604.
    Citations: 59     Fields:    Translation:HumansCells
  70. Frangogiannis NG, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, Winkelmann K, Michael LH, Lawler J, Entman ML. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005 Jun 07; 111(22):2935-42. PMID: 15927970.
    Citations: 139     Fields:    Translation:AnimalsCells
  71. Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med. 2005 Apr-Jun; 9(2):421-37. PMID: 15963261.
    Citations: 25     Fields:    Translation:Animals
  72. Saumet A, Slimane MB, Lanotte M, Lawler J, Dubernard V. Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells. Blood. 2005 Jul 15; 106(2):658-67. PMID: 15784731.
    Citations: 34     Fields:    Translation:HumansCells
  73. Isenberg JS, Calzada MJ, Zhou L, Guo N, Lawler J, Wang XQ, Frazier WA, Roberts DD. Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Matrix Biol. 2005 Apr; 24(2):110-23. PMID: 15890262.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  74. Zhang X, Galardi E, Duquette M, Delic M, Lawler J, Parangi S. Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Mar 15; 11(6):2337-44. PMID: 15788685.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  75. Sund M, Hamano Y, Sugimoto H, Sudhakar A, Soubasakos M, Yerramalla U, Benjamin LE, Lawler J, Kieran M, Shah A, Kalluri R. Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2934-9. PMID: 15710885.
    Citations: 53     Fields:    Translation:AnimalsCells
  76. Short SM, Derrien A, Narsimhan RP, Lawler J, Ingber DE, Zetter BR. Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol. 2005 Feb 14; 168(4):643-53. PMID: 15716381.
    Citations: 60     Fields:    Translation:HumansCells
  77. Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell. 2005 Feb 11; 120(3):421-33. PMID: 15707899.
    Citations: 669     Fields:    Translation:AnimalsCells
  78. Shaked Y, Bertolini F, Man S, Rogers MS, Cervi D, Foutz T, Rawn K, Voskas D, Dumont DJ, Ben-David Y, Lawler J, Henkin J, Huber J, Hicklin DJ, D'Amato RJ, Kerbel RS. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell. 2005 Jan; 7(1):101-11. PMID: 15652753.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  79. Nör JE, Dipietro L, Murphy-Ullrich JE, Hynes RO, Lawler J, Polverini PJ. Activation of Latent TGF-ß1 by Thrombospondin-1 is a Major Component of Wound Repair. Oral Biosci Med. 2005; 2(2):153-161. PMID: 21822445.
    Citations: 13     
  80. Calzada MJ, Annis DS, Zeng B, Marcinkiewicz C, Banas B, Lawler J, Mosher DF, Roberts DD. Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. J Biol Chem. 2004 Oct 01; 279(40):41734-43. PMID: 15292271.
    Citations: 44     Fields:    Translation:HumansCells
  81. Yee KO, Streit M, Hawighorst T, Detmar M, Lawler J. Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol. 2004 Aug; 165(2):541-52. PMID: 15277228.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  82. Lawler J, Detmar M. Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol. 2004 Jun; 36(6):1038-45. PMID: 15094119.
    Citations: 87     Fields:    Translation:HumansCells
  83. Adams JC, Lawler J. The thrombospondins. Int J Biochem Cell Biol. 2004 Jun; 36(6):961-8. PMID: 15094109.
    Citations: 180     Fields:    Translation:HumansAnimalsCells
  84. Niu Q, Perruzzi C, Voskas D, Lawler J, Dumont DJ, Benjamin LE. Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer Biol Ther. 2004 Apr; 3(4):402-5. PMID: 14739779.
    Citations: 18     Fields:    Translation:HumansCells
  85. Cursiefen C, Masli S, Ng TF, Dana MR, Bornstein P, Lawler J, Streilein JW. Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci. 2004 Apr; 45(4):1117-24. PMID: 15037577.
    Citations: 63     Fields:    Translation:Animals
  86. Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, Sudhakar A, Kalluri R. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 2004 Mar 01; 64(5):1570-4. PMID: 14996710.
    Citations: 53     Fields:    Translation:AnimalsCells
  87. Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, Argraves WS, Liau G. Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans. J Cell Biochem. 2004 Mar 01; 91(4):766-76. PMID: 14991768.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  88. Pimanda JE, Ganderton T, Maekawa A, Yap CL, Lawler J, Kershaw G, Chesterman CN, Hogg PJ. Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice. J Biol Chem. 2004 May 14; 279(20):21439-48. PMID: 14981081.
    Citations: 20     Fields:    Translation:AnimalsCells
  89. Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas TN, Rosenkranz AR. Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis. Nephron Exp Nephrol. 2004; 96(2):e31-8. PMID: 14988590.
    Citations: 3     Fields:    Translation:Animals
  90. Wang S, Wu Z, Sorenson CM, Lawler J, Sheibani N. Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration. Dev Dyn. 2003 Dec; 228(4):630-42. PMID: 14648840.
    Citations: 66     Fields:    Translation:Animals
  91. Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12917-22. PMID: 14561896.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  92. Kipnes J, Carlberg AL, Loredo GA, Lawler J, Tuan RS, Hall DJ. Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro. Osteoarthritis Cartilage. 2003 Jun; 11(6):442-54. PMID: 12801484.
    Citations: 24     Fields:    Translation:AnimalsCells
  93. Lee T, Nesselroth SM, Olson ET, Esemuede N, Lawler J, Sumpio BE, Gahtan V. Thrombospondin-1-induced vascular smooth muscle cell chemotaxis: the role of the type 3 repeat and carboxyl terminal domains. J Cell Biochem. 2003 Jun 01; 89(3):500-6. PMID: 12761883.
    Citations: 2     Fields:    Translation:AnimalsCells
  94. Gutierrez LS, Suckow M, Lawler J, Ploplis VA, Castellino FJ. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis. 2003 Feb; 24(2):199-207. PMID: 12584168.
    Citations: 27     Fields:    Translation:Animals
  95. Yee KO, Duquette M, Ludlow A, Lawler J. Purification and analysis of thrombospondin-1. Curr Protoc Cell Biol. 2003 Feb; Chapter 10:Unit 10.10. PMID: 18228414.
    Citations: 2     Fields:    Translation:HumansCells
  96. Yano K, Brown LF, Lawler J, Miyakawa T, Detmar M. Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phase. J Invest Dermatol. 2003 Jan; 120(1):14-9. PMID: 12535193.
    Citations: 13     Fields:    Translation:Animals
  97. Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH. Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol. 2002 Oct 28; 159(2):373-82. PMID: 12391027.
    Citations: 108     Fields:    Translation:HumansCells
  98. Agah A, Kyriakides TR, Lawler J, Bornstein P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am J Pathol. 2002 Sep; 161(3):831-9. PMID: 12213711.
    Citations: 132     Fields:    Translation:Animals
  99. Lawler J. Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med. 2002 Jan-Mar; 6(1):1-12. PMID: 12003665.
    Citations: 198     Fields:    Translation:AnimalsCells
  100. Lawler J, Miao WM, Duquette M, Bouck N, Bronson RT, Hynes RO. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol. 2001 Nov; 159(5):1949-56. PMID: 11696456.
    Citations: 37     Fields:    Translation:Animals
  101. Miao WM, Seng WL, Duquette M, Lawler P, Laus C, Lawler J. Thrombospondin-1 type 1 repeat recombinant proteins inhibit tumor growth through transforming growth factor-beta-dependent and -independent mechanisms. Cancer Res. 2001 Nov 01; 61(21):7830-9. PMID: 11691800.
    Citations: 59     Fields:    Translation:HumansAnimals
  102. Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12485-90. PMID: 11606713.
    Citations: 155     Fields:    Translation:AnimalsCells
  103. Miao WM, Vasile E, Lane WS, Lawler J. CD36 associates with CD9 and integrins on human blood platelets. Blood. 2001 Mar 15; 97(6):1689-96. PMID: 11238109.
    Citations: 34     Fields:    Translation:HumansCells
  104. Nesselroth SM, Willis AI, Fuse S, Olson ET, Lawler J, Sumpio BE, Gahtan V. The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis. J Vasc Surg. 2001 Mar; 33(3):595-600. PMID: 11241132.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  105. Riessen R, Fenchel M, Chen H, Axel DI, Karsch KR, Lawler J. Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):47-54. PMID: 11145932.
    Citations: 40     Fields:    Translation:HumansCells
  106. Chen H, Herndon ME, Lawler J. The cell biology of thrombospondin-1. Matrix Biol. 2000 Dec; 19(7):597-614. PMID: 11102749.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  107. Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J. C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem. 2001 Mar 02; 276(9):6485-98. PMID: 11067851.
    Citations: 81     Fields:    Translation:HumansCells
  108. Lawler J. The functions of thrombospondin-1 and-2. Curr Opin Cell Biol. 2000 Oct; 12(5):634-40. PMID: 10978901.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  109. Majluf-Cruz A, Manns JM, Uknis AB, Yang X, Colman RW, Harris RB, Frazier W, Lawler J, DeLa Cadena RA. Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays. J Lab Clin Med. 2000 Oct; 136(4):292-302. PMID: 11039850.
    Citations: 10     Fields:    Translation:HumansCells
  110. Chen H, Deere M, Hecht JT, Lawler J. Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. J Biol Chem. 2000 Aug 25; 275(34):26538-44. PMID: 10852928.
    Citations: 40     Fields:    Translation:HumansCells
  111. Abdelouahed M, Ludlow A, Brunner G, Lawler J. Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1. J Biol Chem. 2000 Jun 16; 275(24):17933-6. PMID: 10849431.
    Citations: 11     Fields:    Translation:AnimalsCells
  112. Newton G, Weremowicz S, Morton CC, Jenkins NA, Gilbert DJ, Copeland NG, Lawler J. The thrombospondin-4 gene. Mamm Genome. 1999 Oct; 10(10):1010-6. PMID: 10501972.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  113. Iruela-Arispe ML, Lombardo M, Krutzsch HC, Lawler J, Roberts DD. Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats. Circulation. 1999 Sep 28; 100(13):1423-31. PMID: 10500044.
    Citations: 110     Fields:    Translation:AnimalsCells
  114. Sipes JM, Krutzsch HC, Lawler J, Roberts DD. Cooperation between thrombospondin-1 type 1 repeat peptides and alpha(v)beta(3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation. J Biol Chem. 1999 Aug 06; 274(32):22755-62. PMID: 10428859.
    Citations: 17     Fields:    Translation:HumansCells
  115. Streit M, Velasco P, Brown LF, Skobe M, Richard L, Riccardi L, Lawler J, Detmar M. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol. 1999 Aug; 155(2):441-52. PMID: 10433937.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  116. Eda S, Lawler J, Sherman IW. Plasmodium falciparum-infected erythrocyte adhesion to the type 3 repeat domain of thrombospondin-1 is mediated by a modified band 3 protein. Mol Biochem Parasitol. 1999 May 25; 100(2):195-205. PMID: 10391381.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  117. Tucker RP, Hagios C, Chiquet-Ehrismann R, Lawler J, Hall RJ, Erickson CA. Thrombospondin-1 and neural crest cell migration. Dev Dyn. 1999 Apr; 214(4):312-22. PMID: 10213387.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  118. Hecht JT, Montufar-Solis D, Decker G, Lawler J, Daniels K, Duke PJ. Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes. Matrix Biol. 1998 Dec; 17(8-9):625-33. PMID: 9923655.
    Citations: 41     Fields:    Translation:HumansCells
  119. Magnetto S, Bruno-Bossio G, Voland C, Lecerf J, Lawler J, Delmas P, Silverstein R, Clezardin P. CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1. Cell Biochem Funct. 1998 Sep; 16(3):211-21. PMID: 9747513.
    Citations: 6     Fields:    Translation:AnimalsCells
  120. Adams JC, Seed B, Lawler J. Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1. EMBO J. 1998 Sep 01; 17(17):4964-74. PMID: 9724633.
    Citations: 34     Fields:    Translation:AnimalsCells
  121. Hecht JT, Deere M, Putnam E, Cole W, Vertel B, Chen H, Lawler J. Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues. Matrix Biol. 1998 Aug; 17(4):269-78. PMID: 9749943.
    Citations: 41     Fields:    Translation:HumansCells
  122. Guo N, Zabrenetzky VS, Chandrasekaran L, Sipes JM, Lawler J, Krutzsch HC, Roberts DD. Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. Cancer Res. 1998 Jul 15; 58(14):3154-62. PMID: 9679984.
    Citations: 16     Fields:    Translation:HumansCells
  123. Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell. 1998 Jun 26; 93(7):1159-70. PMID: 9657149.
    Citations: 403     Fields:    Translation:AnimalsCells
  124. Volpert OV, Lawler J, Bouck NP. A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6343-8. PMID: 9600967.
    Citations: 49     Fields:    Translation:HumansAnimals
  125. Urry LA, Whittaker CA, Duquette M, Lawler J, DeSimone DW. Thrombospondins in early Xenopus embryos: dynamic patterns of expression suggest diverse roles in nervous system, notochord, and muscle development. Dev Dyn. 1998 Apr; 211(4):390-407. PMID: 9566958.
    Citations: 9     Fields:    Translation:AnimalsCells
  126. Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998 Mar 01; 101(5):982-92. PMID: 9486968.
    Citations: 180     Fields:    Translation:AnimalsCells
  127. Riessen R, Kearney M, Lawler J, Isner JM. Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries. Am Heart J. 1998 Feb; 135(2 Pt 1):357-64. PMID: 9489988.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  128. Merle B, Malaval L, Lawler J, Delmas P, Clezardin P. Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1. J Cell Biochem. 1997 Oct 01; 67(1):75-83. PMID: 9328841.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  129. Tucker RP, Hagios C, Chiquet-Ehrismann R, Lawler J. In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo. Dev Dyn. 1997 Mar; 208(3):326-37. PMID: 9056637.
    Citations: 10     Fields:    Translation:Animals
  130. Clezardin P, Lawler J, Amiral J, Quentin G, Delmas P. Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1. Biochem J. 1997 Feb 01; 321 ( Pt 3):819-27. PMID: 9032471.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  131. Stellmach V, Volpert OV, Crawford SE, Lawler J, Hynes RO, Bouck N. Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts. Eur J Cancer. 1996 Dec; 32A(14):2394-400. PMID: 9059327.
    Citations: 9     Fields:    Translation:AnimalsCells
  132. Incardona F, Lawler J, Cataldo D, Panet A, Legrand Y, Foidart JM, Legrand C. Heparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells. J Cell Biochem. 1996 Sep 15; 62(4):431-42. PMID: 8891889.
    Citations: 6     Fields:    Translation:HumansCells
  133. Higazi AA, Upson RH, Cohen RL, Manuppello J, Bognacki J, Henkin J, McCrae KR, Kounnas MZ, Strickland DK, Preissner KT, Lawler J, Cines DB. Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood. 1996 Jul 15; 88(2):542-51. PMID: 8695802.
    Citations: 11     Fields:    Translation:AnimalsCells
  134. Rabhi-Sabile S, Pidard D, Lawler J, Renesto P, Chignard M, Legrand C. Proteolysis of thrombospondin during cathepsin-G-induced platelet aggregation: functional role of the 165-kDa carboxy-terminal fragment. FEBS Lett. 1996 May 13; 386(1):82-6. PMID: 8635609.
    Citations: 10     Fields:    Translation:Humans
  135. Tucker RP, Adams JC, Lawler J. Thrombospondin-4 is expressed by early osteogenic tissues in the chick embryo. Dev Dyn. 1995 Aug; 203(4):477-90. PMID: 7496039.
    Citations: 13     Fields:    Translation:AnimalsCells
  136. Qabar A, Derick L, Lawler J, Dixit V. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. J Biol Chem. 1995 May 26; 270(21):12725-9. PMID: 7759526.
    Citations: 10     Fields:    Translation:AnimalsCells
  137. Lawler J, McHenry K, Duquette M, Derick L. Characterization of human thrombospondin-4. J Biol Chem. 1995 Feb 10; 270(6):2809-14. PMID: 7852353.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  138. Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J. Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec; 24(3):435-9. PMID: 7713493.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  139. Schultz-Cherry S, Lawler J, Murphy-Ullrich JE. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem. 1994 Oct 28; 269(43):26783-8. PMID: 7929414.
    Citations: 76     Fields:    Translation:AnimalsCells
  140. Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J. 1994 Sep; 8(12):929-38. PMID: 7522194.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  141. Adamson GJ, Gellman H, Brumfield RH, Kuschner SH, Lawler JW. Flexible implant resection arthroplasty of the proximal interphalangeal joint in patients with systemic inflammatory arthritis. J Hand Surg Am. 1994 May; 19(3):378-84. PMID: 8056962.
    Citations: 3     Fields:    Translation:Humans
  142. Adams JC, Lawler J. Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1. Mol Biol Cell. 1994 Apr; 5(4):423-37. PMID: 7519904.
    Citations: 33     Fields:    Translation:HumansCells
  143. Qabar AN, Lin Z, Wolf FW, O'Shea KS, Lawler J, Dixit VM. Thrombospondin 3 is a developmentally regulated heparin binding protein. J Biol Chem. 1994 Jan 14; 269(2):1262-9. PMID: 8288588.
    Citations: 13     Fields:    Translation:AnimalsCells
  144. Ketis NV, Lawler J, Bendena WG. Extracellular matrix components affect the pattern of protein synthesis of endothelial cells responding to hyperthermia. In Vitro Cell Dev Biol Anim. 1993 Oct; 29A(10):768-72. PMID: 8118611.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  145. Lawler J, Duquette M, Urry L, McHenry K, Smith TF. The evolution of the thrombospondin gene family. J Mol Evol. 1993 Jun; 36(6):509-16. PMID: 8350346.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  146. San Antonio JD, Slover J, Lawler J, Karnovsky MJ, Lander AD. Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin. Biochemistry. 1993 May 11; 32(18):4746-55. PMID: 8490019.
    Citations: 15     Fields:    Translation:Cells
  147. Adams JC, Lawler J. Diverse mechanisms for cell attachment to platelet thrombospondin. J Cell Sci. 1993 Apr; 104 ( Pt 4):1061-71. PMID: 8314891.
    Citations: 17     Fields:    Translation:HumansCells
  148. Adams J, Lawler J. Extracellular matrix: the thrombospondin family. Curr Biol. 1993 Mar; 3(3):188-90. PMID: 15335796.
    Citations: 23     Fields:    
  149. Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K, DeSimone DW. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. J Cell Biol. 1993 Feb; 120(4):1059-67. PMID: 8432726.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  150. Legrand C, Thibert V, Dubernard V, Bégault B, Lawler J. Molecular requirements for the interaction of thrombospondin with thrombin-activated human platelets: modulation of platelet aggregation. Blood. 1992 Apr 15; 79(8):1995-2003. PMID: 1562725.
    Citations: 12     Fields:    Translation:HumansCells
  151. Corless CL, Mendoza A, Collins T, Lawler J. Colocalization of thrombospondin and syndecan during murine development. Dev Dyn. 1992 Apr; 193(4):346-58. PMID: 1380845.
    Citations: 26     Fields:    Translation:Animals
  152. Lawler J, Ferro P, Duquette M. Expression and mutagenesis of thrombospondin. Biochemistry. 1992 Feb 04; 31(4):1173-80. PMID: 1734965.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  153. Lawler J, Duquette M, Ferro P, Copeland NG, Gilbert DJ, Jenkins NA. Characterization of the murine thrombospondin gene. Genomics. 1991 Nov; 11(3):587-600. PMID: 1774063.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  154. Lawler J, Duquette M, Ferro P. Cloning and sequencing of chicken thrombospondin. J Biol Chem. 1991 May 05; 266(13):8039-43. PMID: 2022631.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  155. Ketis NV, Lawler J. Effects of thrombospondin antibody on the recovery of endothelial cells from hyperthermia. J Cell Sci. 1990 Jun; 96 ( Pt 2):263-70. PMID: 2211867.
    Citations: 2     Fields:    Translation:AnimalsCells
  156. Coetzer T, Palek J, Lawler J, Liu SC, Jarolim P, Lahav M, Prchal JT, Wang W, Alter BP, Schewitz G, et al. Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood. 1990 Jun 01; 75(11):2235-44. PMID: 2346784.
    Citations: 15     Fields:    Translation:HumansCells
  157. Sherwood JA, Roberts DD, Spitalnik SL, Lawler JW, Miller LH, Howard RJ. Falciparum malaria parasitized erythrocytes bind to a carboxy-terminal thrombospondin fragment and not the amino-terminal heparin-binding region. Mol Biochem Parasitol. 1990 May; 40(2):173-81. PMID: 2194122.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  158. Lambert S, Yu H, Prchal JT, Lawler J, Ruff P, Speicher D, Cheung MC, Kan YW, Palek J. cDNA sequence for human erythrocyte ankyrin. Proc Natl Acad Sci U S A. 1990 Mar; 87(5):1730-4. PMID: 1689849.
    Citations: 43     Fields:    Translation:HumansCells
  159. Korsgren C, Lawler J, Lambert S, Speicher D, Cohen CM. Complete amino acid sequence and homologies of human erythrocyte membrane protein band 4.2. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):613-7. PMID: 2300550.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  160. Lawler J, Hynes RO. An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin. Blood. 1989 Nov 01; 74(6):2022-7. PMID: 2478219.
    Citations: 49     Fields:    Translation:HumansCells
  161. Jarolim P, Palek J, Coetzer TL, Lawler J, Velez-Garcia E, Fradera J, Charles A, Jacob HS, Moake JL. Severe hemolysis and red cell fragmentation caused by the combination of a spectrin mutation with a thrombotic microangiopathy. Am J Hematol. 1989 Sep; 32(1):50-6. PMID: 2667341.
    Citations:    Fields:    Translation:HumansCells
  162. Oquendo P, Hundt E, Lawler J, Seed B. CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Cell. 1989 Jul 14; 58(1):95-101. PMID: 2473841.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  163. Lawler J, Weinstein R, Hynes RO. Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol. 1988 Dec; 107(6 Pt 1):2351-61. PMID: 2848850.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  164. Lawler J, Coetzer TL, Mankad VN, Moore RB, Prchal JT, Palek J. Spectrin-alpha I/61: a new structural variant of alpha-spectrin in a double-heterozygous form of hereditary pyropoikilocytosis. Blood. 1988 Oct; 72(4):1412-5. PMID: 3167214.
    Citations: 4     Fields:    Translation:Humans
  165. Dainiak N, Warren HB, Kreczko S, Riordan MA, Feldman L, Lawler J, Cohen AM, Davies PF. Acetylated lipoproteins impair erythroid growth factor release from endothelial cells. J Clin Invest. 1988 Mar; 81(3):834-43. PMID: 3278006.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  166. Ketis NV, Lawler J, Hoover RL, Karnovsky MJ. Effects of heat shock on the expression of thrombospondin by endothelial cells in culture. J Cell Biol. 1988 Mar; 106(3):893-904. PMID: 3279055.
    Citations: 9     Fields:    Translation:AnimalsCells
  167. Coetzer TL, Lawler J, Liu SC, Prchal JT, Gualtieri RJ, Brain MC, Dacie JV, Palek J. Partial ankyrin and spectrin deficiency in severe, atypical hereditary spherocytosis. N Engl J Med. 1988 Jan 28; 318(4):230-4. PMID: 2961992.
    Citations: 18     Fields:    Translation:HumansCells
  168. Cohen AM, Liu SC, Lawler J, Derick L, Palek J. Identification of the protein 4.1 binding site to phosphatidylserine vesicles. Biochemistry. 1988 Jan 26; 27(2):614-9. PMID: 3349050.
    Citations: 10     Fields:    Translation:HumansCells
  169. Coetzer T, Lawler J, Prchal JT, Palek J. Molecular determinants of clinical expression of hereditary elliptocytosis and pyropoikilocytosis. Blood. 1987 Sep; 70(3):766-72. PMID: 3620700.
    Citations: 7     Fields:    Translation:HumansCells
  170. Clezardin P, Hunter NR, Lawler J, Dawes J, McGregor JL. Production, characterization, and use of monoclonal antibodies directed against human blood platelet thrombospondin: immunologic comparison with human endothelial and fibroblast thrombospondins. Semin Thromb Hemost. 1987 Jul; 13(3):261-75. PMID: 3317839.
    Citations: 2     Fields:    Translation:HumansCells
  171. Lawler J, Hynes RO. Structural organization of the thrombospondin molecule. Semin Thromb Hemost. 1987 Jul; 13(3):245-54. PMID: 3686017.
    Citations: 6     Fields:    Translation:HumansCells
  172. Sloand EM, Kenney DM, Chao FC, Lawler J, Tullis JL. Platelet antithrombin defect in malignancy: platelet protein alterations. Blood. 1987 Feb; 69(2):479-85. PMID: 3801664.
    Citations:    Fields:    Translation:HumansCells
  173. Lawler J, Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol. 1986 Nov; 103(5):1635-48. PMID: 2430973.
    Citations: 134     Fields:    Translation:HumansCells
  174. Clezardin P, Hunter NR, Lawler JW, Pratt DA, McGregor JL, Pepper DS, Dawes J. Structural and immunological comparison of human thrombospondins isolated from platelets and from culture supernatants of endothelial cells and fibroblasts. Evidence for a thrombospondin polymorphism. Eur J Biochem. 1986 Sep 15; 159(3):569-79. PMID: 3758079.
    Citations: 4     Fields:    Translation:HumansCells
  175. Lawler J. The structural and functional properties of thrombospondin. Blood. 1986 May; 67(5):1197-209. PMID: 3516249.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  176. Lawler J, Cohen AM, Chao FC, Moriarty DJ. Thrombospondin in essential thrombocythemia. Blood. 1986 Feb; 67(2):555-8. PMID: 3510684.
    Citations: 3     Fields:    Translation:HumansCells
  177. Lawler J, Connolly JE, Ferro P, Derick LH. Thrombin and chymotrypsin interactions with thrombospondin. Ann N Y Acad Sci. 1986; 485:273-87. PMID: 3471148.
    Citations: 16     Fields:    Translation:Cells
  178. Dainiak N, Kreczko S, Cohen A, Pannell R, Lawler J. Primary human marrow cultures for erythroid bursts in a serum-substituted system. Exp Hematol. 1985 Nov; 13(10):1073-9. PMID: 4054248.
    Citations: 6     Fields:    Translation:HumansCells
  179. Liu SC, Zhai S, Lawler J, Palek J. Hemin-mediated dissociation of erythrocyte membrane skeletal proteins. J Biol Chem. 1985 Oct 05; 260(22):12234-9. PMID: 4044594.
    Citations: 15     Fields:    Translation:HumansCells
  180. Lawler J, Coetzer TL, Palek J, Jacob HS, Luban N. Sp alpha I/65: a new variant of the alpha subunit of spectrin in hereditary elliptocytosis. Blood. 1985 Sep; 66(3):706-9. PMID: 4027386.
    Citations: 12     Fields:    Translation:Humans
  181. Lawler J, Derick LH, Connolly JE, Chen JH, Chao FC. The structure of human platelet thrombospondin. J Biol Chem. 1985 Mar 25; 260(6):3762-72. PMID: 2579080.
    Citations: 53     Fields:    Translation:HumansCells
  182. Lahav J, Lawler J, Gimbrone MA. Thrombospondin interactions with fibronectin and fibrinogen. Mutual inhibition in binding. Eur J Biochem. 1984 Nov 15; 145(1):151-6. PMID: 6489349.
    Citations: 22     Fields:    Translation:HumansCells
  183. Lawler J, Liu SC, Palek J, Prchal J. A molecular defect of spectrin in a subset of patients with hereditary elliptocytosis. Alterations in the alpha-subunit domain involved in spectrin self-association. J Clin Invest. 1984 Jun; 73(6):1688-95. PMID: 6725555.
    Citations: 13     Fields:    Translation:HumansCells
  184. Lawler J, Liu SC, Street A, Palek J. Abnormalities in spectrin structure and function in hereditary pyropoikilocytosis and hereditary elliptocytosis. Prog Clin Biol Res. 1984; 159:191-204. PMID: 6473460.
    Citations:    Fields:    Translation:HumansCells
  185. Lawler J, Palek J, Liu SC, Prchal J, Butler WM. Molecular heterogeneity of hereditary pyropoikilocytosis: identification of a second variant of the spectrin alpha-subunit. Blood. 1983 Dec; 62(6):1182-9. PMID: 6640107.
    Citations: 12     Fields:    Translation:HumansCells
  186. Lawler J, Simons ER. Cooperative binding of calcium to thrombospondin. The effect of calcium on the circular dichroism and limited tryptic digestion of thrombospondin. J Biol Chem. 1983 Oct 25; 258(20):12098-101. PMID: 6630182.
    Citations: 22     Fields:    Translation:HumansCells
  187. Dainiak N, Davies G, Kalmanti M, Lawler J, Kulkarni V. Platelet-derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro. J Clin Invest. 1983 May; 71(5):1206-14. PMID: 6853708.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  188. Lawler J, Liu SC, Palek J, Prchal J. Molecular defect of spectrin in hereditary pyropoikilocytosis. Alterations in the trypsin-resistant domain involved in spectrin self-association. J Clin Invest. 1982 Nov; 70(5):1019-30. PMID: 7130392.
    Citations: 14     Fields:    Translation:HumansCells
  189. Lawler J, Chao FC, Cohen CM. Evidence for calcium-sensitive structure in platelet thrombospondin. Isolation and partial characterization of thrombospondin in the presence of calcium. J Biol Chem. 1982 Oct 25; 257(20):12257-65. PMID: 7118943.
    Citations: 25     Fields:    Translation:HumansCells
  190. Margossian SS, Lawler JW, Slayter HS. Physical characterization of platelet thrombospondin. J Biol Chem. 1981 Jul 25; 256(14):7495-500. PMID: 7251605.
    Citations: 22     Fields:    Translation:HumansCells
  191. Lawler JW, Slayter HS. The release of heparin binding peptides from platelet thrombospondin by proteolytic action of thrombin, plasmin and trypsin. Thromb Res. 1981 May 01; 22(3):267-79. PMID: 6458114.
    Citations: 22     Fields:    Translation:HumansCells
  192. Lawler JW. Prediction of the secondary structure of platelet factor 4 and beta-thromboglobulin from their amino acid sequences. Thromb Res. 1981 Jan 1-15; 21(1-2):121-7. PMID: 6165091.
    Citations: 5     Fields:    Translation:HumansCells
  193. Lawler JW, Chao FC, Fang PH. The effect of ultraviolet light on platelets: platelet activation and inhibition of thrombin-mediated functions. Thromb Res. 1979 Feb-Mar; 14(2-3):489-94. PMID: 442018.
    Citations:    Fields:    Translation:HumansCells
  194. Lawler JW, Slayter HS, Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem. 1978 Dec 10; 253(23):8609-16. PMID: 101549.
    Citations: 126     Fields:    Translation:HumansCells