Harvard Catalyst Profiles

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Steven David Freedman, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03DK071851 (FREEDMAN, STEVEN DAVID) Aug 15, 2005 - Jul 31, 2008
    NIH
    TMS treatment for pain in chronic pancreatitis
    Role: Principal Investigator
  2. S07RR018128 (FREEDMAN, STEVEN DAVID) Sep 1, 2002 - Aug 31, 2005
    NIH
    Improvement of AE monitoring
    Role: Principal Investigator
  3. P41RR013622 (GOLDBERGER, ARY LOUIS) Sep 3, 1999 - Aug 28, 2007
    NIH
    Research Resource for Complex Physiologic Signals
    Role: Co-Principal Investigator
  4. R01DK052765 (FREEDMAN, STEVEN DAVID) Sep 20, 1997 - Aug 31, 2008
    NIH
    ACINAR-DUCT CELL COUPLING IN PANCREATIC FUNCTION
    Role: Principal Investigator
  5. M01RR001032 (SUKHATME, VIKAS P) Dec 1, 1977 - Mar 31, 2010
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yakah W, Shah I, Skelton-Badlani D, Freedman SD, Popov YV, Sheth SG. Circulating Mitochondrial DNA as a Diagnostic Biomarker for Predicting Disease Severity in Patients with Acute Pancreatitis. Gastroenterology. 2023 Jan 17. PMID: 36669623.
    Citations:    Fields:    
  2. Vélez C, Freedman SD, Assis DN. Update in Advancing the Gastrointestinal Frontier in Cystic Fibrosis. Clin Chest Med. 2022 Dec; 43(4):743-755. PMID: 36344078.
    Citations:    Fields:    Translation:Humans
  3. Sathe M, Moshiree B, Aliaj E, Lee M, Hudson J, Gifford A, Attel S, Gamel B, Freedman SD, Schwarzenberg SJ, Freeman AJ. Need to study simplification of gastrointestinal medication regimen in cystic fibrosis in the era of highly effective modulators. Pediatr Pulmonol. 2022 Nov 30. PMID: 36448312.
    Citations:    Fields:    
  4. Freedman S, de-Madaria E, Singh VK, Bruckert E, Löhr M, Sutton R, Rebours V, Jones R, Jandhyala R. A simple core dataset for triglyceride-induced acute pancreatitis. Curr Med Res Opin. 2023 Jan; 39(1):37-46. PMID: 36384356.
    Citations:    Fields:    Translation:Humans
  5. Zuberi SA, Shah I, Bocchino RL, Ahmed A, Freedman SD, Kothari DJ, Sheth SG. Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ? Dig Dis Sci. 2022 Nov 01. PMID: 36318379.
    Citations:    Fields:    
  6. Moshiree B, Freeman AJ, Vu PT, Khan U, Ufret-Vincenty C, Heltshe SL, Goss CH, Schwarzenberg SJ, Freedman SD, Borowitz D, Sathe M. Multicenter prospective study showing a high gastrointestinal symptom burden in cystic fibrosis. J Cyst Fibros. 2022 Oct 29. PMID: 36319569.
    Citations:    Fields:    
  7. Schwarzenberg SJ, Vu PT, Skalland M, Hoffman LR, Pope C, Gelfond D, Narkewicz MR, Nichols DP, Heltshe SL, Donaldson SH, Frederick CA, Kelly A, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Solomon GM, Stalvey MS, Clancy JP, Rowe SM, Freedman SD. Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI. J Cyst Fibros. 2022 Oct 21. PMID: 36280527.
    Citations:    Fields:    
  8. Shah I, Bocchino R, Ahmed A, Freedman SD, Kothari DJ, Sheth SG. Impact of recurrent acute pancreatitis on the natural history and progression to chronic pancreatitis. Pancreatology. 2022 Dec; 22(8):1084-1090. PMID: 36150985.
    Citations:    Fields:    Translation:Humans
  9. Tintara S, Shah I, Yakah W, Kowalczyk JJ, Sorrento C, Kandasamy C, Ahmed A, Freedman SD, Kothari DJ, Sheth SG. Comparison of Opioid-Based Patient-Controlled Analgesia with Physician-Directed Analgesia in Acute Pancreatitis: A Retrospective Cohort Study. Dig Dis Sci. 2022 Jun 06. PMID: 35666365.
    Citations:    Fields:    
  10. Tintara S, Shah I, Yakah W, Ahmed A, Sorrento CS, Kandasamy C, Freedman SD, Kothari DJ, Sheth SG. Evaluating the accuracy of American Society for Gastrointestinal Endoscopy guidelines in patients with acute gallstone pancreatitis with choledocholithiasis. World J Gastroenterol. 2022 Apr 28; 28(16):1692-1704. PMID: 35581962; PMCID: PMC9048789.
    Citations:    Fields:    Translation:Humans
  11. Shah I, Bocchino R, Yakah W, Ahmed A, Freedman SD, Kothari DJ, Sheth SG. Evaluating Outcomes and Misuse in Opioid-Dependent Chronic Pancreatitis Using a State-Mandated Monitoring System. Dig Dis Sci. 2022 12; 67(12):5493-5499. PMID: 35305166.
    Citations:    Fields:    
  12. Nichols DP, Paynter AC, Heltshe SL, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Rosenfeld M, Sagel SD, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Clancy JP, Kirby S, Van Dalfsen JM, Kloster MH, Rowe SM. Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial. Am J Respir Crit Care Med. 2022 03 01; 205(5):529-539. PMID: 34784492; PMCID: PMC8906485.
    Citations: 3     Fields:    Translation:Humans
  13. Shah I, Yakah W, Ahmed A, Kandasamy C, Tintara S, Sorrento C, Freedman SD, Kothari DJ, Sheth SG. Extrapancreatic Complications in Hospitalized Patients With Mild Acute Pancreatitis Are Associated With Poorer Outcomes: Results From a Single-Center Study. Pancreas. 2022 02 01; 51(2):177-182. PMID: 35404894.
    Citations:    Fields:    Translation:Humans
  14. Santoro KL, Yakah W, Singh P, Ramiro-Cortijo D, Medina-Morales E, Freedman SD, Martin CR. Acetaminophen and Xenobiotic Metabolites in Human Milk and the Development of Bronchopulmonary Dysplasia and Retinopathy of Prematurity in a Cohort of Extremely Preterm Infants. J Pediatr. 2022 05; 244:224-229.e3. PMID: 35093319; PMCID: PMC9152735.
    Citations: 1     Fields:    Translation:Humans
  15. Scully KJ, Jay LT, Freedman S, Sawicki GS, Uluer A, Finkelstein JS, Putman MS. The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis. Nutrients. 2022 Jan 12; 14(2). PMID: 35057491; PMCID: PMC8777582.
    Citations: 1     Fields:    Translation:Humans
  16. Sorrento C, Shah I, Yakah W, Ahmed A, Tintara S, Kandasamy C, Freedman SD, Kothari DJ, Sheth SG. Inpatient Alcohol Cessation Counseling Is Associated With a Lower 30-Day Hospital Readmission in Acute Alcoholic Pancreatitis. J Clin Gastroenterol. 2022 10 01; 56(9):e313-e317. PMID: 34999646.
    Citations:    Fields:    
  17. Ahmed A, Anand AN, Shah I, Yakah W, Freedman SD, Thomas R, Sheth SG. Prospective evaluation of sleep disturbances in chronic pancreatitis and its impact on quality of life: a pilot study. Sleep Breath. 2022 12; 26(4):1683-1691. PMID: 34981297.
    Citations:    Fields:    
  18. Kandasamy C, Shah I, Yakah W, Ahmed A, Tintara S, Sorrento C, Freedman SD, Kothari DJ, Sheth SG. The Impact of an Inpatient Pancreatitis Service and Educational Intervention Program on the Outcome of Acute Pancreatitis. Am J Med. 2022 03; 135(3):350-359.e2. PMID: 34717902.
    Citations:    Fields:    Translation:Humans
  19. Sathe M, Moshiree B, Vu PT, Khan U, Heltshe SL, Romasco M, Freedman SD, Schwarzenberg SJ, Goss CH, Freeman AJ. Utilization of electronic patient-reported outcome measures in cystic fibrosis research: Application to the GALAXY study. J Cyst Fibros. 2021 07; 20(4):605-611. PMID: 34305007; PMCID: PMC8403637.
    Citations: 1     Fields:    Translation:Humans
  20. Ahmed A, Fisher JC, Pochapin MB, Freedman SD, Kothari DJ, Shah PC, Sheth SG. Hyperlipasemia in absence of acute pancreatitis is associated with elevated D-dimer and adverse outcomes in COVID 19 disease. Pancreatology. 2021 Jun; 21(4):698-703. PMID: 33741267.
    Citations: 6     Fields:    Translation:HumansCells
  21. Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM. PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy. J Cyst Fibros. 2021 03; 20(2):205-212. PMID: 33619012; PMCID: PMC8686210.
    Citations: 8     Fields:    Translation:Humans
  22. Ahmed A, Kothari DJ, Wardlaw S, Freedman SD, Sheth SG. Reducing Hospitalization in Mild Acute Pancreatitis: Results of Long-term Follow-up. J Clin Gastroenterol. 2021 02 01; 55(2):180-186. PMID: 32301837.
    Citations: 1     Fields:    Translation:Humans
  23. Freeman AJ, Sathe M, Aliaj E, Borowitz D, Fogarty B, Goss CH, Freedman S, Heltshe SL, Khan U, Riva D, Roman C, Romasco M, Schwarzenberg SJ, Ufret-Vincenty CA, Moshiree B. Designing the GALAXY study: Partnering with the cystic fibrosis community to optimize assessment of gastrointestinal symptoms. J Cyst Fibros. 2021 07; 20(4):598-604. PMID: 33451899; PMCID: PMC8273187.
    Citations: 1     Fields:    Translation:Humans
  24. Yakah W, Ramiro-Cortijo D, Singh P, Brown J, Stoll B, Kulkarni M, Oosterloo BC, Burrin D, Maddipati KR, Fichorova RN, Freedman SD, Martin CR. Parenteral Fish-Oil Containing Lipid Emulsions Limit Initial Lipopolysaccharide-Induced Host Immune Responses in Preterm Pigs. Nutrients. 2021 Jan 12; 13(1). PMID: 33445698; PMCID: PMC7828127.
    Citations: 2     Fields:    Translation:HumansAnimals
  25. Yakah W, Singh P, Brown J, Stoll B, Burrin D, Premkumar MH, Otu HH, Gu X, Dillon ST, Libermann TA, Freedman SD, Martin CR. Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs. Am J Physiol Gastrointest Liver Physiol. 2021 02 01; 320(2):G227-G239. PMID: 33236951; PMCID: PMC7948117.
    Citations: 2     Fields:    Translation:HumansAnimals
  26. Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse EE, Lehoux SD, Pandell N, Lim CM, Clohessy JG, Grossman J, Gonzalez R, Del Pino SP, Daaboul G, Sawhney MS, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy LB, Hidalgo M, Muthuswamy SK. PDX-derived organoids model in vivo drug response and secrete biomarkers. JCI Insight. 2020 11 05; 5(21). PMID: 32990680.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Singh P, Sanchez-Fernandez LL, Ramiro-Cortijo D, Ochoa-Allemant P, Perides G, Liu Y, Medina-Morales E, Yakah W, Freedman SD, Martin CR. Maltodextrin-induced intestinal injury in a neonatal mouse model. Dis Model Mech. 2020 08 27; 13(8). PMID: 32753526.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Lusman SS, Borowitz D, Marshall BC, Narkewicz MR, Gonska T, Grand RJ, Simon RH, Mascarenhas MR, Schwarzenberg SJ, Freedman SD. DIGEST: Developing innovative gastroenterology specialty training. J Cyst Fibros. 2021 07; 20(4):586-590. PMID: 32736950; PMCID: PMC7387932.
    Citations:    Fields:    Translation:Humans
  29. Abu-El-Haija M, Lowe M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Lin TK, Liu Q, Mascarenhas MR, Maqbool A, McFerron B, Morinville V, Nathan J, Ooi CY, Perito E, Pohl JF, Schwarzenberg SJ, Shah U, Troendle D, Werlin S, Wilschanski M, Zimmerman B, Uc A. Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium. Pancreatology. 2020 06; 20(4):781-784. PMID: 32332002.
    Citations:    Fields:    Translation:Humans
  30. Ahmed A, Yakah W, Freedman SD, Kothari DJ, Sheth SG. Evaluation of Opioid Use in Acute Pancreatitis in Absence of Chronic Pancreatitis: Absence of Opioid Dependence an Important Feature. Am J Med. 2020 10; 133(10):1209-1218. PMID: 32272099.
    Citations: 4     Fields:    Translation:Humans
  31. Ramiro-Cortijo D, Singh P, Liu Y, Medina-Morales E, Yakah W, Freedman SD, Martin CR. Breast Milk Lipids and Fatty Acids in Regulating Neonatal Intestinal Development and Protecting against Intestinal Injury. Nutrients. 2020 Feb 19; 12(2). PMID: 32092925; PMCID: PMC7071444.
    Citations: 15     Fields:    Translation:Humans
  32. Perito ER, Palermo TM, Pohl JF, Mascarenhas M, Abu-El-Haija M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer M, Gonska T, Heyman MB, Himes RW, Husain SZ, Lin T, Liu Q, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Rhee S, Schwarzenberg SJ, Shah U, Troendle DM, Werlin S, Wilschanski M, Zheng Y, Zimmerman MB, Lowe M, Uc A. Factors Associated With Frequent Opioid Use in Children With Acute Recurrent and Chronic Pancreatitis. J Pediatr Gastroenterol Nutr. 2020 01; 70(1):106-114. PMID: 31567889.
    Citations: 2     Fields:    Translation:Humans
  33. Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort. J Pediatr Gastroenterol Nutr. 2019 11; 69(5):599-606. PMID: 31651815.
    Citations: 3     Fields:    Translation:Humans
  34. Gabel ME, Galante GJ, Freedman SD. Gastrointestinal and Hepatobiliary Disease in Cystic Fibrosis. Semin Respir Crit Care Med. 2019 12; 40(6):825-841. PMID: 31659728.
    Citations: 2     Fields:    Translation:Humans
  35. Yakah W, Singh P, Perides G, Brown J, Freedman SD, Martin CR. Developmental Accretion of Docosahexaenoic Acid Is Independent of Fatty Acid Transporter Expression in Brain and Lung Tissues of C57BL/6 and Fat1 Mice. J Nutr. 2019 10 01; 149(10):1724-1731. PMID: 31179494; PMCID: PMC6768804.
    Citations:    Fields:    Translation:Animals
  36. Yang J, Zaman MM, Vlasakov I, Roy R, Huang L, Martin CR, Freedman SD, Serhan CN, Moses MA. Adipocytes promote ovarian cancer chemoresistance. Sci Rep. 2019 09 16; 9(1):13316. PMID: 31527632.
    Citations: 29     Fields:    Translation:HumansCells
  37. Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data from the INSPPIRE Cohort. J Pediatr Gastroenterol Nutr. 2019 Aug 27. PMID: 31460885.
    Citations:    
  38. Akinsulire O, Perides G, Anez-Bustillos L, Cluette-Brown J, Nedder A, Pollack E, Singh P, Liu Y, Sanchez-Fernandez LL, Obregon E, Bicak E, Kiefer S, Yakah W, Gutierrez HV, Dao DT, Vurma M, Ehling S, Gordon D, DeMichele S, Freedman SD, Martin CR. Early Enteral Administration of a Complex Lipid Emulsion Supplement Prevents Postnatal Deficits in Docosahexaenoic and Arachidonic Acids and Increases Tissue Accretion of Lipophilic Nutrients in Preterm Piglets. JPEN J Parenter Enteral Nutr. 2020 01; 44(1):69-79. PMID: 31441521; PMCID: PMC6980285.
    Citations: 6     Fields:    Translation:Animals
  39. Witztum JL, Gaudet D, Freedman SD, Alexander VJ, Digenio A, Williams KR, Yang Q, Hughes SG, Geary RS, Arca M, Stroes ESG, Bergeron J, Soran H, Civeira F, Hemphill L, Tsimikas S, Blom DJ, O'Dea L, Bruckert E. Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome. N Engl J Med. 2019 08 08; 381(6):531-542. PMID: 31390500.
    Citations: 83     Fields:    Translation:HumansCTClinical Trials
  40. Liu QY, Abu-El-Haija M, Husain SZ, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Lin TK, Maqbool A, Mascarenhas M, McFerron BA, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Risk Factors for Rapid Progression From Acute Recurrent to Chronic Pancreatitis in Children: Report From INSPPIRE. J Pediatr Gastroenterol Nutr. 2019 08; 69(2):206-211. PMID: 31136562; PMCID: PMC6699635.
    Citations: 5     Fields:    Translation:Humans
  41. Lin TK, Abu-El-Haija M, Nathan JD, Palermo JP, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Liu Q, Maqbool A, Mascarenhas M, McFerron B, Morinville VD, Ooi CY, Perito E, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE. J Clin Gastroenterol. 2019 07; 53(6):e232-e238. PMID: 29864067; PMCID: PMC6275137.
    Citations: 9     Fields:    Translation:Humans
  42. Ketwaroo G, Sealock RJ, Freedman S, Hart PA, Othman M, Wassef W, Banks P, Vege SS, Gardner T, Yadav D, Sheth S, Kanwal F. Quality of Care Indicators in Patients with Acute Pancreatitis. Dig Dis Sci. 2019 09; 64(9):2514-2526. PMID: 31152333.
    Citations: 2     Fields:    Translation:Humans
  43. Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu-El-Haija M, Abberbock JN, Lowe ME, Yadav D. Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors. J Pediatr Gastroenterol Nutr. 2019 04; 68(4):566-573. PMID: 30897605; PMCID: PMC6492264.
    Citations: 17     Fields:    Translation:Humans
  44. Tess A, Freedman SD, Kent T, Libman H. How Would You Treat This Patient With Gallstone Pancreatitis?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 02 05; 170(3):175-181. PMID: 30716756.
    Citations: 2     Fields:    Translation:Humans
  45. Singh P, Ochoa-Allemant P, Brown J, Perides G, Freedman SD, Martin CR. Effect of polyunsaturated fatty acids on postnatal ileum development using the fat-1 transgenic mouse model. Pediatr Res. 2019 03; 85(4):556-565. PMID: 30653193; PMCID: PMC6397682.
    Citations: 5     Fields:    Translation:AnimalsCells
  46. Stevens J, Wyatt C, Brown P, Patel D, Grujic D, Freedman SD. Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study in Patients With Cystic Fibrosis Receiving Enteral Feeding. J Pediatr Gastroenterol Nutr. 2018 10; 67(4):527-532. PMID: 30074573; PMCID: PMC6155360.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  47. Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Rhee S, Pohl JF, Perito ER, Palermo JJ, Ooi CY, Liu Q, Lin TK, Morinville VD, McFerron BA, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Lowe ME. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas. 2018 09; 47(8):967-973. PMID: 30059474.
    Citations: 3     Fields:    Translation:Humans
  48. Kothari D, Babineau M, Hall M, Freedman SD, Shapiro NI, Sheth SG. Preventing Hospitalization in Mild Acute Pancreatitis Using a Clinical Pathway in the Emergency Department. J Clin Gastroenterol. 2018 09; 52(8):734-741. PMID: 29095424.
    Citations: 1     Fields:    Translation:Humans
  49. Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T. Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE. J Pediatr Gastroenterol Nutr. 2018 08; 67(2):232-236. PMID: 29746340; PMCID: PMC6059991.
    Citations: 11     Fields:    Translation:Humans
  50. Shanahan KH, Yu X, Miller LG, Freedman SD, Martin CR. Early Serum Gut Hormone Concentrations Associated With Time to Full Enteral Feedings in Preterm Infants. J Pediatr Gastroenterol Nutr. 2018 07; 67(1):97-102. PMID: 29620597.
    Citations: 1     Fields:    Translation:Humans
  51. Freedman SD. Breast Milk Fats and Lipids: Expanding Benefits to Fragile Infant Populations. Breastfeed Med. 2018 04; 13(S1):S26-S27. PMID: 29624422.
    Citations:    Fields:    Translation:HumansAnimals
  52. Kothari D, Struyvenberg MR, Perillo MC, Ezaz G, Freedman SD, Sheth SG. Extra-pancreatic complications, especially hemodialysis predict mortality and length of stay, in ICU patients admitted with acute pancreatitis. Gastroenterol Rep (Oxf). 2018 Aug; 6(3):202-209. PMID: 30151205; PMCID: PMC6101622.
    Citations: 2     
  53. Carrion A, Borowitz DS, Freedman SD, Siracusa CM, Goralski JL, Hadjiliadis D, Srinivasan S, Stokes DC. Reduction of Recurrence Risk of Pancreatitis in Cystic Fibrosis With Ivacaftor: Case Series. J Pediatr Gastroenterol Nutr. 2018 03; 66(3):451-454. PMID: 29045347.
    Citations: 17     Fields:    Translation:HumansPHPublic Health
  54. Freedman SD, Wilschanski M, Schwarzenberg SJ. Advancing the GI frontier for patients with CF. J Cyst Fibros. 2018 01; 17(1):1-2. PMID: 29208346.
    Citations: 2     Fields:    Translation:Humans
  55. Thibaut A, Russo C, Hurtado-Puerto AM, Morales-Quezada JL, Deitos A, Petrozza JC, Freedman S, Fregni F. Effects of Transcranial Direct Current Stimulation, Transcranial Pulsed Current Stimulation, and Their Combination on Brain Oscillations in Patients with Chronic Visceral Pain: A Pilot Crossover Randomized Controlled Study. Front Neurol. 2017; 8:576. PMID: 29163341; PMCID: PMC5672558.
    Citations: 7     
  56. Freedman SD, Wilschanski M. Introduction. J Cyst Fibros. 2017 11; 16 Suppl 2:S1. PMID: 28986025.
    Citations:    Fields:    Translation:Humans
  57. Struyvenberg MR, Fong ZV, Martin CR, Tseng JF, Clancy TE, Fernández-Del Castillo C, Tillman HJ, Bellin MD, Freedman SD. Impact of Treatments on Diabetic Control and Gastrointestinal Symptoms After Total Pancreatectomy. Pancreas. 2017 10; 46(9):1188-1195. PMID: 28902790.
    Citations: 3     Fields:    Translation:Humans
  58. Kothari D, Ketwaroo G, Freedman SD, Sheth SG. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing: Results of a 20-Year Study. Pancreas. 2017 08; 46(7):887-890. PMID: 28697128.
    Citations:    Fields:    Translation:Humans
  59. Freedman SD. Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation. Am J Manag Care. 2017 07; 23(12 Suppl):S220-S228. PMID: 28727476.
    Citations: 5     Fields:    Translation:Humans
  60. Freedman S, Orenstein D, Black P, Brown P, McCoy K, Stevens J, Grujic D, Clayton R. Increased Fat Absorption From Enteral Formula Through an In-line Digestive Cartridge in Patients With Cystic Fibrosis. J Pediatr Gastroenterol Nutr. 2017 07; 65(1):97-101. PMID: 28471913.
    Citations: 7     Fields:    Translation:HumansCells
  61. Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kumar S, Lowe ME, Morinville VD, Ooi CY, Palermo J, Pohl JF, Schwarzenberg SJ, Werlin S, Wilschanski M, Zimmerman MB, Uc A. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017 07; 46(6):764-769. PMID: 28609364.
    Citations: 8     Fields:    Translation:Humans
  62. Kothari D, Ketwaroo G, Sawhney MS, Freedman SD, Sheth SG. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study. Pancreas. 2017 07; 46(6):770-775. PMID: 28609365.
    Citations: 1     Fields:    Translation:Humans
  63. Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kumar S, Lowe ME, Morinville VD, Ooi CY, Palermo J, Pohl JF, Schwarzenberg SJ, Werlin S, Wilschanski M, Zimmerman MB, Uc A. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017 Jun 22. PMID: 28650396.
    Citations:    
  64. Kothari D, Ketwaroo G, Sawhney MS, Freedman SD, Sheth SG. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study. Pancreas. 2017 Jun 22. PMID: 28650387.
    Citations:    Fields:    
  65. Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER. High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery. J Am Geriatr Soc. 2017 Aug; 65(8):e109-e116. PMID: 28555781.
    Citations: 35     Fields:    Translation:Humans
  66. Giefer MJ, Lowe ME, Werlin SL, Zimmerman B, Wilschanski M, Troendle D, Schwarzenberg SJ, Pohl JF, Palermo J, Ooi CY, Morinville VD, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Uc A. Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations. J Pediatr. 2017 07; 186:95-100. PMID: 28502372; PMCID: PMC5506853.
    Citations: 19     Fields:    Translation:Humans
  67. Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T. Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management. Am J Gastroenterol. 2017 Oct; 112(10):1604-1611. PMID: 28374818; PMCID: PMC5908471.
    Citations: 19     Fields:    Translation:Humans
  68. Sheth SG, Conwell DL, Whitcomb DC, Alsante M, Anderson MA, Barkin J, Brand R, Cote GA, Freedman SD, Gelrud A, Gorelick F, Lee LS, Morgan K, Pandol S, Singh VK, Yadav D, Wilcox CM, Hart PA. Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest. Pancreatology. 2017 May - Jun; 17(3):419-430. PMID: 28268158.
    Citations: 4     Fields:    Translation:Humans
  69. Struyvenberg MR, Martin CR, Freedman SD. Practical guide to exocrine pancreatic insufficiency - Breaking the myths. BMC Med. 2017 02 10; 15(1):29. PMID: 28183317.
    Citations: 33     Fields:    Translation:Humans
  70. Cohen J, MacArthur KL, Atsawarungruangkit A, Perillo MC, Martin CR, Berzin TM, Shapiro NI, Sawhney MS, Freedman SD, Sheth SG. Defining the diagnostic value of hyperlipasemia for acute pancreatitis in the critically ill. Pancreatology. 2017 Mar - Apr; 17(2):176-181. PMID: 28237616.
    Citations: 4     Fields:    Translation:Humans
  71. Maki KC, Johns C, Harris WS, Puder M, Freedman SD, Thorsteinsson T, Daak A, Rabinowicz AL, Sancilio FD. Bioequivalence Demonstration for O-3 Acid Ethyl Ester Formulations: Rationale for Modification of Current Guidance. Clin Ther. 2017 Mar; 39(3):652-658. PMID: 28189365.
    Citations: 4     Fields:    Translation:Humans
  72. Martin CR, Stoll B, Cluette-Brown J, Akinkuotu AC, Olutoye OO, Gura KM, Singh P, Zaman MM, Perillo MC, Puder M, Freedman SD, Burrin D. Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA. Nutr Res. 2017 Mar; 39:51-60. PMID: 28385289.
    Citations: 5     Fields:    Translation:Animals
  73. Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Schwarzenberg SJ, Troendle DM, Yen E, Uc A. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr. 2017 01; 64(1):95-103. PMID: 27782962.
    Citations: 16     Fields:    Translation:Humans
  74. Wilschanski M, Yaakov Y, Omari I, Zaman M, Martin CR, Cohen-Cymberknoh M, Shoseyov D, Kerem E, Dasilva D, Sheth S, Uluer A, O'Sullivan BP, Freedman S. Comparison of Nasal Potential Difference and Intestinal Current Measurements as Surrogate Markers for CFTR Function. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e92-e97. PMID: 27496797.
    Citations: 4     Fields:    Translation:Humans
  75. Thibaut A, Russo C, Morales-Quezada L, Hurtado-Puerto A, Deitos A, Freedman S, Carvalho S, Fregni F. Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity. Neurosci Lett. 2017 01 10; 637:207-214. PMID: 27765610; PMCID: PMC5541936.
    Citations: 6     Fields:    Translation:Humans
  76. Schwarzenberg SJ, Hempstead SE, McDonald CM, Powers SW, Wooldridge J, Blair S, Freedman S, Harrington E, Murphy PJ, Palmer L, Schrader AE, Shiel K, Sullivan J, Wallentine M, Marshall BC, Leonard AR. Enteral tube feeding for individuals with cystic fibrosis: Cystic Fibrosis Foundation evidence-informed guidelines. J Cyst Fibros. 2016 11; 15(6):724-735. PMID: 27599607.
    Citations: 10     Fields:    Translation:Humans
  77. Freedman SD, Schwarzenberg SJ. Beyond the lungs: The new GI frontier. J Cyst Fibros. 2016 07; 15(4):409-10. PMID: 27264963.
    Citations: 1     Fields:    Translation:Humans
  78. Kumar S, Ooi CY, Werlin S, Abu-El-Haija M, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Lin TK, Lowe ME, Morinville V, Palermo JJ, Pohl JF, Schwarzenberg SJ, Troendle D, Wilschanski M, Zimmerman MB, Uc A. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE. JAMA Pediatr. 2016 06 01; 170(6):562-9. PMID: 27064572; PMCID: PMC5317277.
    Citations: 66     Fields:    Translation:Humans
  79. Husain SZ, Morinville V, Pohl J, Abu-El-Haija M, Bellin MD, Freedman S, Hegyi P, Heyman MB, Himes R, Ooi CY, Schwarzenberg SJ, Usatin D, Uc A. Toxic-metabolic Risk Factors in Pediatric Pancreatitis: Recommendations for Diagnosis, Management, and Future Research. J Pediatr Gastroenterol Nutr. 2016 Apr; 62(4):609-17. PMID: 26594832; PMCID: PMC4805437.
    Citations: 9     Fields:    Translation:Humans
  80. Ting J, Wilson L, Schwarzenberg SJ, Himes R, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Husain SZ, Kumar S, Morinville VD, Lowe ME, Ooi CY, Pohl JF, Troendle D, Usatin D, Werlin SL, Wilschanski M, Heyman MB, Uc A. Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry. J Pediatr Gastroenterol Nutr. 2016 Mar; 62(3):443-9. PMID: 26704866; PMCID: PMC4767646.
    Citations: 16     Fields:    Translation:Humans
  81. Martin CR, Cheesman A, Brown J, Makda M, Kutner AJ, DaSilva D, Zaman M, Freedman SD. Factors Determining Optimal Fatty Acid Absorption in Preterm Infants. J Pediatr Gastroenterol Nutr. 2016 Jan; 62(1):130-6. PMID: 26252920; PMCID: PMC4691401.
    Citations: 11     Fields:    Translation:Humans
  82. Assis DN, Freedman SD. Gastrointestinal Disorders in Cystic Fibrosis. Clin Chest Med. 2016 Mar; 37(1):109-18. PMID: 26857772.
    Citations: 5     Fields:    Translation:Humans
  83. Bliss LA, Yang CJ, Eskander MF, de Geus SW, Callery MP, Kent TS, Moser AJ, Freedman SD, Tseng JF. Surgical management of chronic pancreatitis: current utilization in the United States. HPB (Oxford). 2015 Sep; 17(9):804-10. PMID: 26216570.
    Citations: 5     Fields:    Translation:Humans
  84. Konnikova Y, Zaman MM, Makda M, D'Onofrio D, Freedman SD, Martin CR. Late Enteral Feedings Are Associated with Intestinal Inflammation and Adverse Neonatal Outcomes. PLoS One. 2015; 10(7):e0132924. PMID: 26172126.
    Citations: 7     Fields:    Translation:Humans
  85. Yang CJ, Bliss LA, Freedman SD, Sheth S, Vollmer CM, Ng SC, Callery MP, Tseng JF. Surgery for chronic pancreatitis: the role of early surgery in pain management. Pancreas. 2015 Jul; 44(5):819-23. PMID: 25882695.
    Citations: 12     Fields:    Translation:Humans
  86. Binker MG, Binker-Cosen MJ, Richards D, Binker-Cosen AA, Freedman SD, Cosen-Binker LI. Omega-3 PUFA docosahexaenoic acid decreases LPS-stimulated MUC5AC production by altering EGFR-related signaling in NCI-H292 cells. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):1047-52. PMID: 26079889.
    Citations: 2     Fields:    Translation:HumansCells
  87. Ketwaroo GA, Freedman SD, Sheth SG. Approach to patients with suspected chronic pancreatitis: a comprehensive review. Pancreas. 2015 Mar; 44(2):173-80. PMID: 25675419.
    Citations: 6     Fields:    Translation:Humans
  88. Schwarzenberg SJ, Bellin M, Husain SZ, Ahuja M, Barth B, Davis H, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Kumar S, Morinville VD, Lowe ME, Nuehring NE, Ooi CY, Pohl JF, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden. J Pediatr. 2015 Apr; 166(4):890-896.e1. PMID: 25556020; PMCID: PMC4380827.
    Citations: 58     Fields:    Translation:Humans
  89. Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, Durie PR, Finley B, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Kumar S, Ooi CY, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014 Sep; 59(3):360-4. PMID: 24824361.
    Citations: 28     Fields:    Translation:Humans
  90. Yang CJ, Bliss LA, Schapira EF, Freedman SD, Ng SC, Windsor JA, Tseng JF. Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention. J Gastrointest Surg. 2014 Oct; 18(10):1863-9. PMID: 24944153.
    Citations: 26     Fields:    Translation:Humans
  91. Martin CR, Zaman MM, Gilkey C, Salguero MV, Hasturk H, Kantarci A, Van Dyke TE, Freedman SD. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. PLoS One. 2014; 9(6):e98773. PMID: 24892762.
    Citations: 25     Fields:    Translation:Animals
  92. Freedman SD, Martin CR, Aspinall MG. Structuring the patient-physician encounter: Joint creation of an actionable roadmap to health. Healthc (Amst). 2014 Jul; 2(2):94-8. PMID: 26250375.
    Citations: 3     Fields:    
  93. Nath BD, Freedman SD, Moser AJ. The Frey procedure is a treatment for chronic pancreatitis, not pancreas divisum. JAMA Surg. 2013 Nov; 148(11):1062. PMID: 24005373.
    Citations: 1     Fields:    Translation:Humans
  94. Ketwaroo G, Brown A, Young B, Kheraj R, Sawhney M, Mortele KJ, Najarian R, Tewani S, Dasilva D, Freedman S, Sheth S. Defining the accuracy of secretin pancreatic function testing in patients with suspected early chronic pancreatitis. Am J Gastroenterol. 2013 Aug; 108(8):1360-6. PMID: 23711627.
    Citations: 18     Fields:    Translation:Humans
  95. Pasca di Magliano M, Forsmark C, Freedman S, Hebrok M, Pasricha PJ, Saluja A, Stanger BZ, Holt J, Serrano J, James SP, Rustgi AK. Advances in acute and chronic pancreatitis: from development to inflammation and repair. Gastroenterology. 2013 Jan; 144(1):e1-4. PMID: 23159450; PMCID: PMC4096699.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  96. Morinville VD, Husain SZ, Bai H, Barth B, Alhosh R, Durie PR, Freedman SD, Himes R, Lowe ME, Pohl J, Werlin S, Wilschanski M, Uc A. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):261-5. PMID: 22357117.
    Citations: 102     Fields:    Translation:Humans
  97. Freedman SD, Martin CR. Do patient-accessible electronic medical records help or complicate shared decision making? Virtual Mentor. 2012 Jul 01; 14(7):560-2. PMID: 23351293.
    Citations: 1     Fields:    Translation:Humans
  98. Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15; 303(4):G474-81. PMID: 22679000.
    Citations: 7     Fields:    Translation:AnimalsCells
  99. Neeman N, Isaac T, Leveille S, Dimonda C, Shin JY, Aronson MD, Freedman SD. Improving doctor-patient communication in the outpatient setting using a facilitation tool: a preliminary study. Int J Qual Health Care. 2012 Aug; 24(4):357-64. PMID: 22190587.
    Citations: 9     Fields:    Translation:Humans
  100. Ooi CY, Nightingale S, Durie PR, Freedman SD. Ursodeoxycholic acid in cystic fibrosis-associated liver disease. J Cyst Fibros. 2012 Jan; 11(1):72-3; author reply 74-75. PMID: 21862443.
    Citations: 6     Fields:    Translation:Humans
  101. Martin CR, Dasilva DA, Cluette-Brown JE, Dimonda C, Hamill A, Bhutta AQ, Coronel E, Wilschanski M, Stephens AJ, Driscoll DF, Bistrian BR, Ware JH, Zaman MM, Freedman SD. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. J Pediatr. 2011 Nov; 159(5):743-749.e1-2. PMID: 21658712; PMCID: PMC3701520.
    Citations: 81     Fields:    Translation:Humans
  102. Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, Freedman SD, Rose LM, Mayer-Hamblett N, Dong Q, Zha J, Stone AJ, Olson ER, Ordoñez CL, Campbell PW, Ashlock MA, Ramsey BW. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18; 363(21):1991-2003. PMID: 21083385; PMCID: PMC3148255.
    Citations: 309     Fields:    Translation:HumansCTClinical Trials
  103. Ooi CY, Dorfman R, Cipolli M, Gonska T, Castellani C, Keenan K, Freedman SD, Zielenski J, Berthiaume Y, Corey M, Schibli S, Tullis E, Durie PR. Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis. Gastroenterology. 2011 Jan; 140(1):153-61. PMID: 20923678.
    Citations: 74     Fields:    Translation:Humans
  104. Fregni F, Potvin K, Dasilva D, Wang X, Lenkinski RE, Freedman SD, Pascual-Leone A. Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain. Eur J Pain. 2011 Jan; 15(1):53-60. PMID: 20822942.
    Citations: 26     Fields:    Translation:HumansCTClinical Trials
  105. Zaman MM, Martin CR, Andersson C, Bhutta AQ, Cluette-Brown JE, Laposata M, Freedman SD. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. Am J Physiol Lung Cell Mol Physiol. 2010 Nov; 299(5):L599-606. PMID: 20656894.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  106. Ooi CY, Gonska T, Durie PR, Freedman SD. Genetic testing in pancreatitis. Gastroenterology. 2010 Jun; 138(7):2202-6, 2206.e1. PMID: 20416310.
    Citations: 2     Fields:    Translation:Humans
  107. Boggio PS, Amancio EJ, Correa CF, Cecilio S, Valasek C, Bajwa Z, Freedman SD, Pascual-Leone A, Edwards DJ, Fregni F. Transcranial DC stimulation coupled with TENS for the treatment of chronic pain: a preliminary study. Clin J Pain. 2009 Oct; 25(8):691-5. PMID: 19920718.
    Citations: 35     Fields:    Translation:Humans
  108. Freedman SD, Uppot RN, Mino-Kenudson M. Case records of the Massachusetts General Hospital. Case 26-2009. A 34-year-old man with cystic fibrosis with abdominal pain and distention. N Engl J Med. 2009 Aug 20; 361(8):807-16. PMID: 19692693.
    Citations:    Fields:    Translation:HumansCells
  109. O'Sullivan BP, Freedman SD. Cystic fibrosis. Lancet. 2009 May 30; 373(9678):1891-904. PMID: 19403164.
    Citations: 418     Fields:    Translation:HumansAnimalsPHPublic Health
  110. Al-Turkmani MR, Andersson C, Alturkmani R, Katrangi W, Cluette-Brown JE, Freedman SD, Laposata M. A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA. J Lipid Res. 2008 Sep; 49(9):1946-54. PMID: 18480495.
    Citations: 16     Fields:    Translation:HumansCells
  111. Andersson C, Al-Turkmani MR, Savaille JE, Alturkmani R, Katrangi W, Cluette-Brown JE, Zaman MM, Laposata M, Freedman SD. Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. J Lipid Res. 2008 Aug; 49(8):1692-700. PMID: 18441018.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  112. Callery MP, Freedman SD. A 21-year-old man with chronic pancreatitis. JAMA. 2008 Apr 02; 299(13):1588-94. PMID: 18319401.
    Citations:    Fields:    Translation:Humans
  113. Al-Turkmani MR, Freedman SD, Laposata M. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):309-18. PMID: 18036797.
    Citations: 19     Fields:    Translation:Humans
  114. Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17255-60. PMID: 17956980.
    Citations: 49     Fields:    Translation:HumansCells
  115. Silva G, Miksad R, Freedman SD, Pascual-Leone A, Jain S, Gomes DL, Amancio EJ, Boggio PS, Correa CF, Fregni F. Treatment of cancer pain with noninvasive brain stimulation. J Pain Symptom Manage. 2007 Oct; 34(4):342-5. PMID: 17903664.
    Citations: 8     Fields:    Translation:Humans
  116. Fregni F, Pascual-Leone A, Freedman SD. Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response? Pancreatology. 2007; 7(5-6):411-22. PMID: 17898531.
    Citations: 14     Fields:    Translation:HumansAnimals
  117. Andersson C, Zaman MM, Jones AB, Freedman SD. Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. J Cyst Fibros. 2008 Jan; 7(1):68-78. PMID: 17889625.
    Citations: 22     Fields:    Translation:AnimalsCells
  118. Pall H, Zielenski J, Jonas MM, DaSilva DA, Potvin KM, Yuan XW, Huang Q, Freedman SD. Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function. J Pediatr. 2007 Sep; 151(3):255-9. PMID: 17719933.
    Citations: 12     Fields:    Translation:Humans
  119. Fang H, Qiu L, Vitkin E, Zaman MM, Andersson C, Salahuddin S, Kimerer LM, Cipolloni PB, Modell MD, Turner BS, Keates SE, Bigio I, Itzkan I, Freedman SD, Bansil R, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy. Appl Opt. 2007 Apr 01; 46(10):1760-9. PMID: 17356619.
    Citations: 17     Fields:    
  120. Freedman SD, Callery MP. Central control of pancreatic cancer pain: protecting the enemy? Gastroenterology. 2007 Mar; 132(3):1191-2. PMID: 17383443.
    Citations: 1     Fields:    
  121. Fregni F, Freedman S, Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol. 2007 Feb; 6(2):188-91. PMID: 17239806.
    Citations: 68     Fields:    Translation:Humans
  122. Fregni F, Gimenes R, Valle AC, Ferreira MJ, Rocha RR, Natalle L, Bravo R, Rigonatti SP, Freedman SD, Nitsche MA, Pascual-Leone A, Boggio PS. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum. 2006 Dec; 54(12):3988-98. PMID: 17133529.
    Citations: 159     Fields:    Translation:Humans
  123. Batal I, Ericsoussi MB, Cluette-Brown JE, O'Sullivan BP, Freedman SD, Savaille JE, Laposata M. Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis. Clin Chem. 2007 Jan; 53(1):78-84. PMID: 17130178.
    Citations: 9     Fields:    Translation:Humans
  124. Beharry S, Ackerley C, Corey M, Kent G, Heng YM, Christensen H, Luk C, Yantiss RK, Nasser IA, Zaman M, Freedman SD, Durie PR. Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Mar; 292(3):G839-48. PMID: 17095751.
    Citations: 15     Fields:    Translation:AnimalsCells
  125. Ollero M, Laposata M, Zaman MM, Blanco PG, Andersson C, Zeind J, Urman Y, Kent G, Alvarez JG, Freedman SD. Evidence of increased flux to n-6 docosapentaenoic acid in phospholipids of pancreas from cftr-/- knockout mice. Metabolism. 2006 Sep; 55(9):1192-200. PMID: 16919538.
    Citations: 9     Fields:    Translation:AnimalsCells
  126. Fregni F, Boggio PS, Valle AC, Rocha RR, Duarte J, Ferreira MJ, Wagner T, Fecteau S, Rigonatti SP, Riberto M, Freedman SD, Pascual-Leone A. A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients. Stroke. 2006 Aug; 37(8):2115-22. PMID: 16809569.
    Citations: 142     Fields:    Translation:Humans
  127. Patrizi F, Freedman SD, Pascual-Leone A, Fregni F. Novel therapeutic approaches to the treatment of chronic abdominal visceral pain. ScientificWorldJournal. 2006 Apr 18; 6:472-90. PMID: 16633700.
    Citations: 8     Fields:    Translation:HumansCells
  128. Fregni F, Boggio PS, Lima MC, Ferreira MJ, Wagner T, Rigonatti SP, Castro AW, Souza DR, Riberto M, Freedman SD, Nitsche MA, Pascual-Leone A. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain. 2006 May; 122(1-2):197-209. PMID: 16564618.
    Citations: 216     Fields:    Translation:HumansCTClinical Trials
  129. Pall H, Zaman MM, Andersson C, Freedman SD. Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice. J Pediatr Gastroenterol Nutr. 2006 Mar; 42(3):275-81. PMID: 16540796.
    Citations: 8     Fields:    Translation:HumansAnimals
  130. Fregni F, Thome-Souza S, Nitsche MA, Freedman SD, Valente KD, Pascual-Leone A. A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy. Epilepsia. 2006 Feb; 47(2):335-42. PMID: 16499758.
    Citations: 63     Fields:    Translation:Humans
  131. Fregni F, DaSilva D, Potvin K, Ramos-Estebanez C, Cohen D, Pascual-Leone A, Freedman SD. Treatment of chronic visceral pain with brain stimulation. Ann Neurol. 2005 Dec; 58(6):971-2. PMID: 16315281.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  132. Blanco PG, Salem RO, Ollero M, Zaman MM, Cluette-Brown JE, Freedman SD, Laposata M. Ethanol administration to cystic fibrosis knockout mice results in increased fatty acid ethyl ester production. Alcohol Clin Exp Res. 2005 Nov; 29(11):2039-45. PMID: 16340462.
    Citations: 3     Fields:    Translation:Animals
  133. Bishop MD, Freedman SD, Zielenski J, Ahmed N, Dupuis A, Martin S, Ellis L, Shea J, Hopper I, Corey M, Kortan P, Haber G, Ross C, Tzountzouris J, Steele L, Ray PN, Tsui LC, Durie PR. The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis. Hum Genet. 2005 Dec; 118(3-4):372-81. PMID: 16193325.
    Citations: 31     Fields:    Translation:Humans
  134. Fregni F, Boggio PS, Mansur CG, Wagner T, Ferreira MJ, Lima MC, Rigonatti SP, Marcolin MA, Freedman SD, Nitsche MA, Pascual-Leone A. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport. 2005 Sep 28; 16(14):1551-5. PMID: 16148743.
    Citations: 182     Fields:    Translation:HumansCTClinical Trials
  135. Fregni F, Monte-Silva KK, Oliveira MB, Freedman SD, Pascual-Leone A, Guedes RC. Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading depression: relevance for clinical applications of brain stimulation. Eur J Neurosci. 2005 Apr; 21(8):2278-84. PMID: 15869525.
    Citations: 3     Fields:    Translation:Animals
  136. Gelrud A, Freedman SD. Autoimmune pancreatitis. J Gastrointest Surg. 2005 Jan; 9(1):2-5. PMID: 15773043.
    Citations: 5     Fields:    Translation:Humans
  137. Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, Shea JC, Kelly C, O'Sullivan BP, Freedman SD. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol. 2004 Sep; 11(5):819-24. PMID: 15358638; PMCID: PMC515258.
    Citations: 37     Fields:    Translation:HumansCells
  138. Gelrud A, Sheth S, Banerjee S, Weed D, Shea J, Chuttani R, Howell DA, Telford JJ, Carr-Locke DL, Regan MM, Ellis L, Durie PR, Freedman SD. Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am J Gastroenterol. 2004 Aug; 99(8):1557-62. PMID: 15307877.
    Citations: 28     Fields:    Translation:Humans
  139. Ollero M, Junaidi O, Zaman MM, Tzameli I, Ferrando AA, Andersson C, Blanco PG, Bialecki E, Freedman SD. Decreased expression of peroxisome proliferator activated receptor gamma in cftr-/- mice. J Cell Physiol. 2004 Aug; 200(2):235-44. PMID: 15174093.
    Citations: 29     Fields:    Translation:AnimalsCells
  140. Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004 Jul; 6(1):33-43. PMID: 15261140.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  141. Blanco PG, Freedman SD, Lopez MC, Ollero M, Comen E, Laposata M, Alvarez JG. Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses. Am J Obstet Gynecol. 2004 May; 190(5):1369-74. PMID: 15167843.
    Citations: 5     Fields:    Translation:Animals
  142. Blanco PG, Zaman MM, Junaidi O, Sheth S, Yantiss RK, Nasser IA, Freedman SD. Induction of colitis in cftr-/- mice results in bile duct injury. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G491-6. PMID: 15064232.
    Citations: 24     Fields:    Translation:Animals
  143. Parker EM, O'Sullivan BP, Shea JC, Regan MM, Freedman SD. Survey of breast-feeding practices and outcomes in the cystic fibrosis population. Pediatr Pulmonol. 2004 Apr; 37(4):362-7. PMID: 15022134.
    Citations: 8     Fields:    Translation:Humans
  144. van Heeckeren AM, Schluchter M, Xue L, Alvarez J, Freedman S, St George J, Davis PB. Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice. Infect Immun. 2004 Mar; 72(3):1479-86. PMID: 14977953.
    Citations: 7     Fields:    Translation:HumansAnimals
  145. Freedman SD, Blanco PG, Zaman MM, Shea JC, Ollero M, Hopper IK, Weed DA, Gelrud A, Regan MM, Laposata M, Alvarez JG, O'Sullivan BP. Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med. 2004 Feb 05; 350(6):560-9. PMID: 14762183.
    Citations: 121     Fields:    Translation:Humans
  146. Dial R, Sun ZY, Freedman SJ. Three conformational states of the p300 CH1 domain define its functional properties. Biochemistry. 2003 Aug 26; 42(33):9937-45. PMID: 12924942.
    Citations: 14     Fields:    Translation:HumansCells
  147. Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol. 2003 Jul; 10(7):504-12. PMID: 12778114.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  148. Sheth S, Shea JC, Bishop MD, Chopra S, Regan MM, Malmberg E, Walker C, Ricci R, Tsui LC, Durie PR, Zielenski J, Freedman SD. Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis. Hum Genet. 2003 Aug; 113(3):286-92. PMID: 12783301.
    Citations: 25     Fields:    Translation:Humans
  149. Pantanowitz L, Freedman SJ, Dezube BJ, Joseph JT. November 2002: a 72-year-old woman with a pineal gland mass. Brain Pathol. 2003 Apr; 13(2):235-6, 239. PMID: 12744478.
    Citations: 2     Fields:    Translation:Humans
  150. Del Castillo IC, Alvarez JG, Freedman SD, Ollero M, Claros L, Song JC, Yoo J, Matthews JB. Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. J Surg Res. 2003 Apr; 110(2):338-43. PMID: 12788663.
    Citations: 2     Fields:    Translation:HumansCells
  151. Chernova MN, Jiang L, Shmukler BE, Schweinfest CW, Blanco P, Freedman SD, Stewart AK, Alper SL. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol. 2003 May 15; 549(Pt 1):3-19. PMID: 12651923; PMCID: PMC2342915.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  152. Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. J Biol Chem. 2003 Apr 11; 278(15):13462-7. PMID: 12556468.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  153. Shea JC, Bishop MD, Parker EM, Gelrud A, Freedman SD. An enteral therapy containing medium-chain triglycerides and hydrolyzed peptides reduces postprandial pain associated with chronic pancreatitis. Pancreatology. 2003; 3(1):36-40. PMID: 12649562.
    Citations: 6     Fields:    Translation:HumansCells
  154. Wang L, Freedman SD. Laboratory tests for the diagnosis of cystic fibrosis. Am J Clin Pathol. 2002 Jun; 117 Suppl:S109-15. PMID: 14569807.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  155. Freedman SD, Weinstein D, Blanco PG, Martinez-Clark P, Urman S, Zaman M, Morrow JD, Alvarez JG. Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid. J Appl Physiol (1985). 2002 May; 92(5):2169-76. PMID: 11960971.
    Citations: 24     Fields:    Translation:AnimalsCells
  156. Freedman SD, Blanco PG, Shea JC, Alvarez JG. Analysis of lipid abnormalities in CF mice. Methods Mol Med. 2002; 70:517-24. PMID: 11917547.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.