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Stewart Harris Lecker, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK062307 (LECKER, STEWART H) Apr 1, 2003 - Aug 31, 2011
    NIH/NIDDK
    Atrogin-1 and Muscle Protein Balance
    Role: Principal Investigator
  2. K08DK002707 (LECKER, STEWART H) Aug 1, 1999 - Jul 31, 2004
    NIH/NIDDK
    MOLECULAR BASIS FOR MUSCLE PROTEIN LOSS IN CACHEXIA
    Role: Principal Investigator
  3. F32AR008463 (LECKER, STEWART H) Dec 27, 1997
    NIH/NIAMS
    MOLECULAR BASIS FOR MUSCLE PROTEIN LOSS IN CACHEXIA
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhuo M, Li J, Lecker SH. Brugada phenocopy induced by hyperkalemia. Kidney Int. 2019 Feb; 95(2):471. PMID: 30665578.
    Citations:    Fields:    
  2. Poyan Mehr A, Sadeghi-Najafabadi M, Chau K, Messmer J, Pai R, Roy N, Friedman D, Pollak MR, Schlondorff J, Naljayan M, Singh T, Lecker SH, Rodby R, Germain M, Rennke H, Stillman IE. The Glomerular Disease Study and Trial Consortium: A Grassroots Initiative to Foster Collaboration and Innovation. Kidney Int Rep. 2019 Jan; 4(1):20-29. PMID: 30596165.
    Citations:    
  3. Ilic LM, Davis RB, Brown RS, Lecker SH. The Interdialytic Creatinine Rise is a novel marker of volume overload and mortality risk in hemodialysis patients. BMC Nephrol. 2018 08 16; 19(1):202. PMID: 30115036.
    Citations:    Fields:    
  4. Hoenig MP, Lecker SH, Zeidel ML. Diagnostic Use of Base Excess in Acid-Base Disorders. N Engl J Med. 2018 08 02; 379(5):494-5. PMID: 30070101.
    Citations:    Fields:    Translation:Humans
  5. Martinelli GB, Olivari D, Re Cecconi AD, Talamini L, Ottoboni L, Lecker SH, Stretch C, Baracos VE, Bathe OF, Resovi A, Giavazzi R, Cervo L, Piccirillo R. Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia. Oncogene. 2016 12 01; 35(48):6212-6222. PMID: 27212031.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. PMID: 26950361.
    Citations: 58     Fields:    Translation:HumansAnimals
  7. Forman DE, Daniels KM, Cahalin LP, Zavin A, Allsup K, Cao P, Santhanam M, Joseph J, Arena R, Lazzari A, Schulze PC, Lecker SH. Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure. J Card Fail. 2014 Jun; 20(6):422-30. PMID: 24704539.
    Citations: 7     Fields:    Translation:Humans
  8. Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 2013 Oct; 62(10):1495-502. PMID: 23866982.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Daniels KM, Zavin A, Allsup K, Joseph J, Arena R, Lazzari AA, Schulze PC, Lecker SH, Brown J, Forman DE. Serum adiponectin in non-cachectic heart failure patients. Int J Cardiol. 2013 Oct 09; 168(4):4363-4. PMID: 23739548.
    Citations:    Fields:    Translation:Humans
  10. Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupin-Furlowe J, McMullen JR, Moss RL, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation. 2012 Nov 27; 126(22):2575-88. PMID: 23095280.
    Citations: 35     Fields:    Translation:AnimalsCells
  11. Lecker SH, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, Schulze PC, Forman DE. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail. 2012 Nov; 5(6):812-8. PMID: 23001918.
    Citations: 40     Fields:    Translation:Humans
  12. Zavin A, Daniels K, Arena R, Allsup K, Lazzari A, Joseph J, Schulze PC, Lecker SH, Forman DE. Adiposity facilitates increased strength capacity in heart failure patients with reduced ejection fraction. Int J Cardiol. 2013 Sep 10; 167(6):2468-71. PMID: 22743190.
    Citations: 5     Fields:    Translation:Humans
  13. Zavin A, Arena R, Joseph J, Allsup K, Daniels K, Schulze PC, Lecker S, Forman DE. Dynamic assessment of ventilatory efficiency during recovery from peak exercise to enhance cardiopulmonary exercise testing. Eur J Prev Cardiol. 2013 Oct; 20(5):779-85. PMID: 22517928.
    Citations:    Fields:    Translation:Humans
  14. Wing SS, Lecker SH, Jagoe RT. Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks. Crit Rev Clin Lab Sci. 2011 Mar-Apr; 48(2):49-70. PMID: 21699435.
    Citations: 16     Fields:    Translation:HumansCells
  15. Lecker SH, Mitch WE. Proteolysis by the ubiquitin-proteasome system and kidney disease. J Am Soc Nephrol. 2011 May; 22(5):821-4. PMID: 21474563.
    Citations: 10     Fields:    Translation:HumansAnimals
  16. Wang H, Liu D, Cao P, Lecker S, Hu Z. Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. Diabetes. 2010 Aug; 59(8):1879-89. PMID: 20522589.
    Citations: 11     Fields:    Translation:AnimalsCells
  17. Lecker SH. Given the science on malnutrition, how does the clinician respond? Practical lessons for and application to the dialysis patient. Clin J Am Soc Nephrol. 2009 Dec; 4 Suppl 1:S64-70. PMID: 19996008.
    Citations: 2     Fields:    Translation:HumansCells
  18. Mearini G, Gedicke C, Schlossarek S, Witt CC, Krämer E, Cao P, Gomes MD, Lecker SH, Labeit S, Willis MS, Eschenhagen T, Carrier L. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc Res. 2010 Jan 15; 85(2):357-66. PMID: 19850579.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  19. Gonçalves DA, Lira EC, Baviera AM, Cao P, Zanon NM, Arany Z, Bedard N, Tanksale P, Wing SS, Lecker SH, Kettelhut IC, Navegantes LC. Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle. Endocrinology. 2009 Dec; 150(12):5395-404. PMID: 19837877.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE, Palmer BM, Maughan DW, Ades PA, Toth MJ. Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function. Circ Heart Fail. 2009 Nov; 2(6):700-6. PMID: 19919996.
    Citations: 28     Fields:    Translation:HumansCells
  21. Cao P, Hanai J, Tanksale P, Imamura S, Sukhatme VP, Lecker SH. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J. 2009 Sep; 23(9):2844-54. PMID: 19406843.
    Citations: 23     Fields:    Translation:AnimalsCells
  22. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren PO. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008 Oct 01; 105(2):353-64. PMID: 18615595.
    Citations: 46     Fields:    Translation:AnimalsCells
  23. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16. PMID: 18806787.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  24. Buettner C, Lecker SH. Molecular basis for statin-induced muscle toxicity: implications and possibilities. Pharmacogenomics. 2008 Aug; 9(8):1133-42. PMID: 18681786.
    Citations: 8     Fields:    Translation:HumansAnimals
  25. Smith IJ, Lecker SH, Hasselgren PO. Calpain activity and muscle wasting in sepsis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E762-71. PMID: 18492780.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  26. Bodonyi-Kovacs G, Lecker SH. Electrolyte-free water clearance: a key to the diagnosis of hypernatremia in resolving acute renal failure. Clin Exp Nephrol. 2008 Feb; 12(1):74-8. PMID: 18180873.
    Citations: 2     Fields:    Translation:Humans
  27. Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 2007 Dec; 6(6):472-83. PMID: 18054316.
    Citations: 471     Fields:    Translation:AnimalsCells
  28. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007 Dec; 117(12):3940-51. PMID: 17992259.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  29. Sacheck JM, Hyatt JP, Raffaello A, Jagoe RT, Roy RR, Edgerton VR, Lecker SH, Goldberg AL. Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J. 2007 Jan; 21(1):140-55. PMID: 17116744.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  30. Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16260-5. PMID: 17053067.
    Citations: 282     Fields:    Translation:AnimalsCells
  31. Bdolah Y, Segal A, Tanksale P, Karumanchi SA, Lecker SH. Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated with uterine smooth muscle involution in the postpartum period. Am J Physiol Regul Integr Comp Physiol. 2007 Feb; 292(2):R971-6. PMID: 17008454.
    Citations: 11     Fields:    Translation:Animals
  32. Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006 Jul; 17(7):1807-19. PMID: 16738015.
    Citations: 266     Fields:    Translation:Cells
  33. Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, Sato K, Zeng L, Schiekofer S, Pimentel D, Lecker S, Taegtmeyer H, Goldberg AL, Walsh K. The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem. 2005 May 27; 280(21):20814-23. PMID: 15781459.
    Citations: 100     Fields:    Translation:AnimalsCells
  34. Cao PR, Kim HJ, Lecker SH. Ubiquitin-protein ligases in muscle wasting. Int J Biochem Cell Biol. 2005 Oct; 37(10):2088-97. PMID: 16125112.
    Citations: 43     Fields:    Translation:HumansAnimals
  35. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 2004 Apr 30; 117(3):399-412. PMID: 15109499.
    Citations: 737     Fields:    Translation:AnimalsCells
  36. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004 Jan; 18(1):39-51. PMID: 14718385.
    Citations: 421     Fields:    Translation:AnimalsCells
  37. Li YP, Lecker SH, Chen Y, Waddell ID, Goldberg AL, Reid MB. TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J. 2003 Jun; 17(9):1048-57. PMID: 12773487.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  38. Lecker SH. Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways? Curr Opin Clin Nutr Metab Care. 2003 May; 6(3):271-5. PMID: 12690258.
    Citations: 18     Fields:    Translation:HumansAnimals
  39. Lecker SH, Goldberg AL. Slowing muscle atrophy: putting the brakes on protein breakdown. J Physiol. 2002 12 15; 545(3):729. PMID: 12482881.
    Citations: 6     Fields:    Translation:Animals
  40. Jagoe RT, Lecker SH, Gomes M, Goldberg AL. Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB J. 2002 Nov; 16(13):1697-712. PMID: 12409312.
    Citations: 76     Fields:    Translation:AnimalsCells
  41. Kwon YT, Xia Z, Davydov IV, Lecker SH, Varshavsky A. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol Cell Biol. 2001 Dec; 21(23):8007-21. PMID: 11689692.
    Citations: 44     Fields:    Translation:AnimalsCells
  42. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14440-5. PMID: 11717410.
    Citations: 415     Fields:    Translation:AnimalsCells
  43. Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000 Aug; 106(3):439-48. PMID: 10930447.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  44. Tarcsa E, Szymanska G, Lecker S, O'Connor CM, Goldberg AL. Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination. J Biol Chem. 2000 Jul 07; 275(27):20295-301. PMID: 10791958.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  45. Lecker SH, Solomon V, Price SR, Kwon YT, Mitch WE, Goldberg AL. Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats. J Clin Invest. 1999 Nov; 104(10):1411-20. PMID: 10562303.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  46. Benzing T, Brandes R, Sellin L, Schermer B, Lecker S, Walz G, Kim E. Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function. Nat Med. 1999 Aug; 5(8):913-8. PMID: 10426315.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  47. Lecker SH, Solomon V, Mitch WE, Goldberg AL. Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr. 1999 01; 129(1S Suppl):227S-237S. PMID: 9915905.
    Citations: 144     Fields:    Translation:HumansAnimals
  48. Solomon V, Lecker SH, Goldberg AL. The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle. J Biol Chem. 1998 Sep 25; 273(39):25216-22. PMID: 9737984.
    Citations: 28     Fields:    Translation:AnimalsCells
  49. Hartl FU, Lecker S, Schiebel E, Hendrick JP, Wickner W. The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane. Cell. 1990 Oct 19; 63(2):269-79. PMID: 2170023.
    Citations: 153     Fields:    Translation:Cells
  50. Lecker SH, Driessen AJ, Wickner W. ProOmpA contains secondary and tertiary structure prior to translocation and is shielded from aggregation by association with SecB protein. EMBO J. 1990 Jul; 9(7):2309-14. PMID: 2192862.
    Citations: 25     Fields:    Translation:Cells
  51. Lecker S, Lill R, Ziegelhoffer T, Georgopoulos C, Bassford PJ, Kumamoto CA, Wickner W. Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro. EMBO J. 1989 Sep; 8(9):2703-9. PMID: 2531087.
    Citations: 95     Fields:    Translation:Cells
  52. Lecker S, Meyer D, Wickner W. Export of prepro-alpha-factor from Escherichia coli. J Biol Chem. 1989 Jan 25; 264(3):1882-6. PMID: 2643604.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Crooke E, Guthrie B, Lecker S, Lill R, Wickner W. ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle. Cell. 1988 Sep 23; 54(7):1003-11. PMID: 2843289.
    Citations: 60     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.