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Elvira Isganaitis, M.D.

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Biography
McGill University, Montreal, Quebec, CanadaMD, CM05/2001Medicine
Harvard School of Public Health, Boston, MAMPH05/2002Quantitative Methods
UCSF, San Francisco, CA06/2005Pediatrics Residency
Mass. General Hospital for Children, Boston, MA08/2008Pediatric Endocrinology Fellowship

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HD091974 (PATTI, MARY E) Dec 30, 2017 - Nov 30, 2020
    NIH
    Impact of Metabolic Health in Type 2 Diabetes on Sperm Epigenetic Marks in Humans: A Novel Intergenerational Mechanism for Metabolic Disease Risk Transmission
    Role: Co-Principal Investigator
  2. R00HD064793 (ISGANAITIS, ELVIRA MARIE) Sep 30, 2010 - Nov 30, 2015
    NIH
    Pathways of Mother to Child Transmission of Metabolic Risk
    Role: Principal Investigator
  3. K99HD064793 (ISGANAITIS, ELVIRA MARIE) Sep 30, 2010 - Nov 30, 2012
    NIH
    Elucidating adiposity in a mouse model of prenatal undernutrition
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler P. Long-Term Complications in Youth-Onset Type 2 Diabetes. N Engl J Med. 2021 07 29; 385(5):416-426. PMID: 34320286.
    Citations: 1     Fields:    Translation:Humans
  2. Isganaitis E. Milky ways: effects of maternal obesity on human milk composition and childhood obesity risk. Am J Clin Nutr. 2021 04 06; 113(4):772-774. PMID: 33742200.
    Citations:    Fields:    Translation:Humans
  3. O'Malley G, Messer LH, Levy CJ, Pinsker JE, Forlenza GP, Isganaitis E, Kudva YC, Ekhlaspour L, Raghinaru D, Lum J, Brown SA. Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial. Diabetes Technol Ther. 2021 Apr; 23(4):245-252. PMID: 33155824.
    Citations:    Fields:    
  4. Ribo S, Sánchez-Infantes D, Martinez-Guino L, García-Mantrana I, Ramon-Krauel M, Tondo M, Arning E, Nofrarías M, Osorio-Conles Ó, Fernández-Pérez A, González-Torres P, Cebrià J, Gavaldà-Navarro A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segalés J, Jiménez-Chillarón JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C. Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health. Sci Transl Med. 2021 03 31; 13(587). PMID: 33790021.
    Citations:    Fields:    Translation:Animals
  5. Wolfs D, Lynes MD, Tseng YH, Pierce S, Bussberg V, Darkwah A, Tolstikov V, Narain NR, Rudolph MC, Kiebish MA, Demerath EW, Fields DA, Isganaitis E. Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity. J Clin Endocrinol Metab. 2021 01 23; 106(2):e943-e956. PMID: 33135728.
    Citations: 1     Fields:    
  6. Isganaitis E, Raghinaru D, Ambler-Osborn L, Pinsker JE, Buckingham BA, Wadwa RP, Ekhlaspour L, Kudva YC, Levy CJ, Forlenza GP, Beck RW, Kollman C, Lum JW, Brown SA, Laffel LM. Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial. Diabetes Technol Ther. 2021 May; 23(5):342-349. PMID: 33216667.
    Citations: 2     Fields:    
  7. Bergenstal RM, Nimri R, Beck RW, Criego A, Laffel L, Schatz D, Battelino T, Danne T, Weinzimer SA, Sibayan J, Johnson ML, Bailey RJ, Calhoun P, Carlson A, Isganaitis E, Bello R, Albanese-O'Neill A, Dovc K, Biester T, Weyman K, Hood K, Phillip M. A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial. Lancet. 2021 01 16; 397(10270):208-219. PMID: 33453783.
    Citations: 5     Fields:    Translation:Humans
  8. Longitudinal Changes in Cardiac Structure and Function From Adolescence to Young Adulthood in Participants With Type 2 Diabetes Mellitus: The TODAY Follow-Up Study. Circ Heart Fail. 2020 06; 13(6):e006685. PMID: 32498621.
    Citations: 4     Fields:    Translation:Humans
  9. Kovatchev B, Anderson SM, Raghinaru D, Kudva YC, Laffel LM, Levy C, Pinsker JE, Wadwa RP, Buckingham B, Doyle FJ, Brown SA, Church MM, Dadlani V, Dassau E, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam DW, Lum J, Beck RW. Erratum. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care 2020;43:607-615. Diabetes Care. 2020 Jun; 43(6):1366. PMID: 32245747.
    Citations:    Fields:    
  10. Kovatchev B, Anderson SM, Raghinaru D, Kudva YC, Laffel LM, Levy C, Pinsker JE, Wadwa RP, Buckingham B, Doyle FJ, Brown SA, Church MM, Dadlani V, Dassau E, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam DW, Lum J, Beck RW. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care. 2020 03; 43(3):607-615. PMID: 31937608.
    Citations: 3     Fields:    Translation:Humans
  11. Kaar JL, Schmiege SJ, Drews K, Higgins J, Walders-Abramson N, Isganaitis E, Willi SM, Marcus MD, Zeitler PS, Kelsey MM. Evaluation of the longitudinal change in health behavior profiles across treatment groups in the TODAY clinical trial. Pediatr Diabetes. 2020 03; 21(2):224-232. PMID: 31886931.
    Citations: 2     Fields:    Translation:Humans
  12. Noor N, Cardenas A, Rifas-Shiman SL, Pan H, Dreyfuss JM, Oken E, Hivert MF, James-Todd T, Patti ME, Isganaitis E. Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood. JAMA Netw Open. 2019 12 02; 2(12):e1916777. PMID: 31880793.
    Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
  13. Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC, Laffel LM, Levy CJ, Pinsker JE, Wadwa RP, Dassau E, Doyle FJ, Anderson SM, Church MM, Dadlani V, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam DW, Kollman C, Beck RW. Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes. N Engl J Med. 2019 10 31; 381(18):1707-1717. PMID: 31618560.
    Citations: 90     Fields:    Translation:Humans
  14. Isganaitis E. Developmental Programming of Body Composition: Update on Evidence and Mechanisms. Curr Diab Rep. 2019 07 20; 19(8):60. PMID: 31327060.
    Citations: 8     Fields:    Translation:HumansAnimals
  15. Isganaitis E, Venditti S, Matthews TJ, Lerin C, Demerath EW, Fields DA. Maternal obesity and the human milk metabolome: associations with infant body composition and postnatal weight gain. Am J Clin Nutr. 2019 07 01; 110(1):111-120. PMID: 30968129.
    Citations: 24     Fields:    Translation:Humans
  16. Brown FM, Isganaitis E, James-Todd T. Much to HAPO FUS About: Increasing Maternal Glycemia in Pregnancy Is Associated With Worsening Childhood Glucose Metabolism. Diabetes Care. 2019 03; 42(3):393-395. PMID: 30787060.
    Citations: 1     Fields:    Translation:Humans
  17. Mulla BM, Noor N, James-Todd T, Isganaitis E, Takoudes TC, Curran A, Warren CE, O'Brien KE, Brown FM. Continuous Glucose Monitoring, Glycemic Variability, and Excessive Fetal Growth in Pregnancies Complicated by Type 1 Diabetes. Diabetes Technol Ther. 2018 06; 20(6):413-419. PMID: 29901410.
    Citations: 5     Fields:    Translation:Humans
  18. Bauman V, Sturkey AC, Sherafat-Kazemzadeh R, McEwan J, Jones PM, Keating A, Isganaitis E, Ricker A, Rother KI. Factitious hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2018 06; 19(4):823-831. PMID: 29464887.
    Citations: 2     Fields:    Translation:Humans
  19. Ma H, Sales VM, Wolf AR, Subramanian S, Matthews TJ, Chen M, Sharma A, Gall W, Kulik W, Cohen DE, Adachi Y, Griffin NW, Gordon JI, Patti ME, Isganaitis E. Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition. Endocrinology. 2017 08 01; 158(8):2441-2452. PMID: 28637315.
    Citations: 2     Fields:    Translation:Animals
  20. Ferris HA, Isganaitis E, Brown F. Time for an End to Juice in the Special Supplemental Nutrition Program for Women, Infants, and Children. JAMA Pediatr. 2017 06 01; 171(6):509-510. PMID: 28437541.
    Citations: 1     Fields:    Translation:Humans
  21. Isganaitis E, Suehiro H, Cardona C. Who's your daddy?: paternal inheritance of metabolic disease risk. Curr Opin Endocrinol Diabetes Obes. 2017 Feb; 24(1):47-55. PMID: 27906710.
    Citations: 8     Fields:    Translation:HumansCells
  22. Costa SM, Isganaitis E, Matthews TJ, Hughes K, Daher G, Dreyfuss JM, da Silva GA, Patti ME. Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells. Int J Obes (Lond). 2016 11; 40(11):1627-1634. PMID: 27531045.
    Citations: 9     Fields:    Translation:HumansCells
  23. Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, De Sousa-Coelho AL, Daher G, Manoli I, Sysol JR, Isganaitis E, Jessen N, Goodyear LJ, Beebe K, Gall W, Venditti CP, Patti ME. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016 Oct; 5(10):926-936. PMID: 27689005.
    Citations: 38     Fields:    
  24. Gonzalez-Franquesa A, Burkart AM, Isganaitis E, Patti ME. What Have Metabolomics Approaches Taught Us About Type 2 Diabetes? Curr Diab Rep. 2016 08; 16(8):74. PMID: 27319324.
    Citations: 13     Fields:    Translation:Humans
  25. Isganaitis E, Rifas-Shiman SL, Oken E, Dreyfuss JM, Gall W, Gillman MW, Patti ME. Associations of cord blood metabolites with early childhood obesity risk. Int J Obes (Lond). 2015 Jul; 39(7):1041-8. PMID: 25804930.
    Citations: 16     Fields:    Translation:Humans
  26. Hivert MF, Perng W, Watkins SM, Newgard CS, Kenny LC, Kristal BS, Patti ME, Isganaitis E, DeMeo DL, Oken E, Gillman MW. Metabolomics in the developmental origins of obesity and its cardiometabolic consequences. J Dev Orig Health Dis. 2015 Apr; 6(2):65-78. PMID: 25631626.
    Citations: 19     Fields:    Translation:HumansAnimals
  27. Perng W, Gillman MW, Fleisch AF, Michalek RD, Watkins SM, Isganaitis E, Patti ME, Oken E. Metabolomic profiles and childhood obesity. Obesity (Silver Spring). 2014 Dec; 22(12):2570-8. PMID: 25251340.
    Citations: 62     Fields:    Translation:Humans
  28. Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AHFM, Patti ME, Ferguson-Smith AC. In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science. 2014 Aug 15; 345(6198):1255903. PMID: 25011554.
    Citations: 200     Fields:    Translation:AnimalsCells
  29. Huang T, Saxena AR, Isganaitis E, James-Todd T. Gender and racial/ethnic differences in the associations of urinary phthalate metabolites with markers of diabetes risk: National Health and Nutrition Examination Survey 2001-2008. Environ Health. 2014 Feb 05; 13(1):6. PMID: 24499162.
    Citations: 39     Fields:    Translation:HumansPHPublic Health
  30. Isganaitis E, Woo M, Ma H, Chen M, Kong W, Lytras A, Sales V, Decoste-Lopez J, Lee KJ, Leatherwood C, Lee D, Fitzpatrick C, Gall W, Watkins S, Patti ME. Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice. Diabetes. 2014 Feb; 63(2):688-700. PMID: 24186867.
    Citations: 29     Fields:    Translation:Animals
  31. Colaneri A, Wang T, Pagadala V, Kittur J, Staffa NG, Peddada SD, Isganaitis E, Patti ME, Birnbaumer L. A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming. PLoS One. 2013; 8(9):e72670. PMID: 24069155.
    Citations: 11     Fields:    Translation:AnimalsCells
  32. Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith AC. An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PLoS Genet. 2012; 8(4):e1002605. PMID: 22511876.
    Citations: 56     Fields:    Translation:HumansAnimals
  33. Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti ME. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev. 2011 Oct; 20(10):1763-9. PMID: 21247245.
    Citations: 43     Fields:    Translation:AnimalsCells
  34. Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti ME. Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes. 2009 May; 58(5):1192-200. PMID: 19208909.
    Citations: 37     Fields:    Translation:AnimalsCells
  35. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes. 2009 Feb; 58(2):460-8. PMID: 19017762.
    Citations: 107     Fields:    Translation:Animals
  36. Isganaitis E, Levitsky LL. Preventing childhood obesity: can we do it? Curr Opin Endocrinol Diabetes Obes. 2008 Feb; 15(1):1-8. PMID: 18185057.
    Citations: 7     Fields:    Translation:Humans
  37. Oge A, Isganaitis E, Jimenez-Chillaron J, Reamer C, Faucette R, Barry K, Przybyla R, Patti ME. In utero undernutrition reduces diabetes incidence in non-obese diabetic mice. Diabetologia. 2007 May; 50(5):1099-108. PMID: 17370059.
    Citations: 7     Fields:    Translation:Animals
  38. Isganaitis E, Lustig RH. Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2451-62. PMID: 16166564.
    Citations: 42     Fields:    Translation:HumansAnimalsPHPublic Health
  39. Isganaitis E, Kamei R, Kohrman AF. Spare the rod and save the child. Virtual Mentor. 2003 Aug 01; 5(8). PMID: 23267533.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.