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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Protein Kinase C.
Connection Strength

9.031
  1. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
    Score: 0.354
  2. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79.
    View in: PubMed
    Score: 0.333
  3. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
    Score: 0.319
  4. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
    Score: 0.300
  5. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.285
  6. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.236
  7. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
    Score: 0.232
  8. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20.
    View in: PubMed
    Score: 0.224
  9. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5.
    View in: PubMed
    Score: 0.216
  10. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8.
    View in: PubMed
    Score: 0.214
  11. Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care. 2005 Nov; 28(11):2803-5.
    View in: PubMed
    Score: 0.209
  12. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26.
    View in: PubMed
    Score: 0.199
  13. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96.
    View in: PubMed
    Score: 0.197
  14. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 2004 Jul 06; 110(1):7-9.
    View in: PubMed
    Score: 0.191
  15. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.174
  16. Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol. 2003; 233:397-422.
    View in: PubMed
    Score: 0.172
  17. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.168
  18. B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol. 2002 Aug 20; 12(16):R554-6.
    View in: PubMed
    Score: 0.167
  19. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
    View in: PubMed
    Score: 0.161
  20. Protein kinase C and the development of diabetic vascular complications. Diabet Med. 2001 Dec; 18(12):945-59.
    View in: PubMed
    Score: 0.159
  21. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
    View in: PubMed
    Score: 0.144
  22. Protein kinase C and myocardial biology and function. Circ Res. 2000 Jun 09; 86(11):1104-6.
    View in: PubMed
    Score: 0.144
  23. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000 May; 21(5):181-7.
    View in: PubMed
    Score: 0.143
  24. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000; 5(3):173-85.
    View in: PubMed
    Score: 0.139
  25. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.136
  26. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Perit Dial Int. 1999; 19 Suppl 2:S222-7.
    View in: PubMed
    Score: 0.130
  27. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun; 47(6):859-66.
    View in: PubMed
    Score: 0.125
  28. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med (Berl). 1998 Jan; 76(1):21-31.
    View in: PubMed
    Score: 0.121
  29. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998; 7(1-2):69-76.
    View in: PubMed
    Score: 0.121
  30. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.121
  31. Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C. Kidney Int Suppl. 1997 Sep; 60:S77-85.
    View in: PubMed
    Score: 0.119
  32. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80.
    View in: PubMed
    Score: 0.119
  33. Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9320-5.
    View in: PubMed
    Score: 0.118
  34. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.117
  35. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 07; 92(1):101-113.
    View in: PubMed
    Score: 0.115
  36. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.112
  37. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.109
  38. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.108
  39. Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression. Contrib Nephrol. 1996; 118:180-7.
    View in: PubMed
    Score: 0.106
  40. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest. 1995 Aug; 96(2):733-40.
    View in: PubMed
    Score: 0.103
  41. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46.
    View in: PubMed
    Score: 0.103
  42. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994 Nov; 43(11):1372-7.
    View in: PubMed
    Score: 0.097
  43. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.096
  44. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9.
    View in: PubMed
    Score: 0.096
  45. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.091
  46. Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes. Diabetes. 1992 Dec; 41(12):1533-9.
    View in: PubMed
    Score: 0.085
  47. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.085
  48. Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C. J Biol Chem. 1990 Aug 15; 265(23):13864-70.
    View in: PubMed
    Score: 0.073
  49. Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes. Diabetes. 1989 Dec; 38(12):1643-6.
    View in: PubMed
    Score: 0.069
  50. Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells. Biochem Biophys Res Commun. 1989 Jul 14; 162(1):381-6.
    View in: PubMed
    Score: 0.068
  51. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.067
  52. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72.
    View in: PubMed
    Score: 0.065
  53. Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells. J Clin Invest. 1989 Jan; 83(1):90-4.
    View in: PubMed
    Score: 0.065
  54. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
    Score: 0.057
  55. Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin. Expert Opin Drug Saf. 2006 Nov; 5(6):835-45.
    View in: PubMed
    Score: 0.056
  56. Molecular targets of diabetic cardiovascular complications. Curr Drug Targets. 2005 Jun; 6(4):487-94.
    View in: PubMed
    Score: 0.051
  57. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42.
    View in: PubMed
    Score: 0.050
  58. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep. 2005 Apr; 5(2):91-7.
    View in: PubMed
    Score: 0.050
  59. Microvascular complications of diabetes. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):215-38, xi-xii.
    View in: PubMed
    Score: 0.047
  60. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.
    View in: PubMed
    Score: 0.043
  61. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 2002 Nov 27; 288(20):2579-88.
    View in: PubMed
    Score: 0.043
  62. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes. 2002 Sep; 51(9):2804-10.
    View in: PubMed
    Score: 0.042
  63. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.040
  64. Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem. 2002 Jan 11; 277(2):1047-57.
    View in: PubMed
    Score: 0.040
  65. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem. 2000 Dec 29; 275(52):40725-31.
    View in: PubMed
    Score: 0.037
  66. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar; 14(3):439-47.
    View in: PubMed
    Score: 0.035
  67. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.035
  68. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.
    View in: PubMed
    Score: 0.033
  69. Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes. Diabetes Care. 1999 Apr; 22 Suppl 3:C31-7.
    View in: PubMed
    Score: 0.033
  70. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation. 1999 Jan 26; 99(3):384-91.
    View in: PubMed
    Score: 0.033
  71. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.033
  72. In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest. 1998 Jul 01; 102(1):72-8.
    View in: PubMed
    Score: 0.031
  73. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. 1998; 7(1-2):55-67.
    View in: PubMed
    Score: 0.030
  74. Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. J Am Soc Nephrol. 1997 Mar; 8(3):426-35.
    View in: PubMed
    Score: 0.029
  75. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med. 1996 Oct; 28(5):427-32.
    View in: PubMed
    Score: 0.028
  76. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 1996 Jul; 45 Suppl 3:S105-8.
    View in: PubMed
    Score: 0.027
  77. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996 Jun; 25(2):255-70.
    View in: PubMed
    Score: 0.027
  78. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest. 1995 Mar; 95(3):1353-62.
    View in: PubMed
    Score: 0.025
  79. Regulation of receptor-mediated endocytosis by phorbol esters. Biochem Pharmacol. 1991 May 01; 41(9):1267-77.
    View in: PubMed
    Score: 0.019
  80. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
    Score: 0.014
  81. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
    View in: PubMed
    Score: 0.011
  82. Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo. Hypertension. 2001 Dec 01; 38(6):1260-5.
    View in: PubMed
    Score: 0.010
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.