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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Insulin.
Connection Strength

2.852
  1. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):92-101.
    View in: PubMed
    Score: 0.249
  2. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 2016 06; 65(6):1462-71.
    View in: PubMed
    Score: 0.225
  3. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
    Score: 0.165
  4. Diabetes: Podocytes lose their footing. Nature. 2010 Nov 04; 468(7320):42-4.
    View in: PubMed
    Score: 0.153
  5. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53.
    View in: PubMed
    Score: 0.150
  6. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89.
    View in: PubMed
    Score: 0.147
  7. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
    View in: PubMed
    Score: 0.132
  8. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.
    View in: PubMed
    Score: 0.131
  9. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
    Score: 0.119
  10. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71.
    View in: PubMed
    Score: 0.091
  11. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.073
  12. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nat Commun. 2019 09 27; 10(1):4427.
    View in: PubMed
    Score: 0.071
  13. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest. 1999 Aug; 104(4):447-57.
    View in: PubMed
    Score: 0.070
  14. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.
    View in: PubMed
    Score: 0.069
  15. PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest. 2016 Mar 01; 126(3):837-53.
    View in: PubMed
    Score: 0.055
  16. Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. Biochem J. 1994 Oct 01; 303 ( Pt 1):43-50.
    View in: PubMed
    Score: 0.050
  17. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.050
  18. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
    Score: 0.046
  19. Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol. 2012 Sep; 32(5):471-8.
    View in: PubMed
    Score: 0.043
  20. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem. 1991 Dec 05; 266(34):23251-6.
    View in: PubMed
    Score: 0.041
  21. A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One. 2011; 6(12):e28311.
    View in: PubMed
    Score: 0.041
  22. Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Mol Endocrinol. 1989 Aug; 3(8):1183-90.
    View in: PubMed
    Score: 0.035
  23. Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester. J Biol Chem. 1989 Apr 05; 264(10):5916-23.
    View in: PubMed
    Score: 0.034
  24. Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I. Diabetes. 1989 Jan; 38(1):123-9.
    View in: PubMed
    Score: 0.034
  25. Intracellular pathways of insulin transport across vascular endothelial cells. Am J Physiol. 1988 Oct; 255(4 Pt 1):C459-64.
    View in: PubMed
    Score: 0.033
  26. Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells. Am J Physiol. 1988 Mar; 254(3 Pt 1):C411-6.
    View in: PubMed
    Score: 0.032
  27. Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol Chem. 1987 May 05; 262(13):6417-24.
    View in: PubMed
    Score: 0.030
  28. Processing and release of insulin and insulin-like growth factor I by macro- and microvascular endothelial cells. Endocrinology. 1986 Nov; 119(5):1904-13.
    View in: PubMed
    Score: 0.029
  29. Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells. Diabetes. 1986 Oct; 35(10):1065-72.
    View in: PubMed
    Score: 0.029
  30. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
    View in: PubMed
    Score: 0.027
  31. Processing and transport of insulin by vascular endothelial cells. Effects of sulfonylureas on insulin receptors. Am J Med. 1985 Sep 20; 79(3B):43-7.
    View in: PubMed
    Score: 0.027
  32. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep. 2005 Apr; 5(2):91-7.
    View in: PubMed
    Score: 0.026
  33. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest. 1985 Mar; 75(3):1028-36.
    View in: PubMed
    Score: 0.026
  34. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80.
    View in: PubMed
    Score: 0.023
  35. Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. J Clin Invest. 1983 Apr; 71(4):974-9.
    View in: PubMed
    Score: 0.023
  36. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.022
  37. Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1983 Mar; 80(5):1308-12.
    View in: PubMed
    Score: 0.022
  38. Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide. J Biol Chem. 1982 Sep 25; 257(18):10869-73.
    View in: PubMed
    Score: 0.022
  39. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002 Jan 22; 105(3):373-9.
    View in: PubMed
    Score: 0.021
  40. Non-parallel evolution of metabolic and growth-promoting functions of insulin. Nature. 1981 Aug 13; 292(5824):644-6.
    View in: PubMed
    Score: 0.020
  41. Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest. 1980 Jul; 66(1):130-40.
    View in: PubMed
    Score: 0.019
  42. Vascular dysfunction in diabetes mellitus. Lancet. 1997 Jul; 350 Suppl 1:SI9-13.
    View in: PubMed
    Score: 0.015
  43. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996 Jun; 25(2):255-70.
    View in: PubMed
    Score: 0.014
  44. Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study. Metabolism. 2015 Oct; 64(10):1316-23.
    View in: PubMed
    Score: 0.013
  45. A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study. Nutr Res. 2014 Jun; 34(6):491-8.
    View in: PubMed
    Score: 0.012
  46. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.012
  47. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J Biol Chem. 1993 May 25; 268(15):11256-64.
    View in: PubMed
    Score: 0.011
  48. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.
    View in: PubMed
    Score: 0.010
  49. Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol. 1987 Oct; 105(4):1595-601.
    View in: PubMed
    Score: 0.008
  50. Cell biology as an approach to the study of the vascular complications of diabetes. Metabolism. 1985 Dec; 34(12 Suppl 1):17-22.
    View in: PubMed
    Score: 0.007
  51. Processing of insulin by bovine endothelial cells in culture. Internalization without degradation. Diabetes. 1984 Aug; 33(8):794-800.
    View in: PubMed
    Score: 0.006
  52. [B17-D-leucine]insulin and [B17-norleucine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1983 Nov; 364(11):1615-26.
    View in: PubMed
    Score: 0.006
  53. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42.
    View in: PubMed
    Score: 0.006
  54. [B22-D-arginine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1982 Dec; 363(12):1449-60.
    View in: PubMed
    Score: 0.006
  55. Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes. J Biol Chem. 1982 Sep 10; 257(17):10001-6.
    View in: PubMed
    Score: 0.005
  56. Demonstration of receptors for insulin and insulin-like growth factors on Swarm rat chondrosarcoma chondrocytes. Evidence that insulin stimulates proteoglycan synthesis through the insulin receptor. J Biol Chem. 1982 Jan 25; 257(2):663-9.
    View in: PubMed
    Score: 0.005
  57. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.005
  58. Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res. 1981; 37:477-538.
    View in: PubMed
    Score: 0.005
  59. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):981-90.
    View in: PubMed
    Score: 0.003
  60. Modulation of the insulin receptor by insulin receptor autoantibodies. Prog Clin Biol Res. 1980; 42:109-26.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.