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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Hyperglycemia.
Connection Strength

2.167
  1. Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol. 2012 Sep; 32(5):471-8.
    View in: PubMed
    Score: 0.284
  2. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306.
    View in: PubMed
    Score: 0.233
  3. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep. 2005 Apr; 5(2):91-7.
    View in: PubMed
    Score: 0.170
  4. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol. 2004 Oct; 122(4):333-8.
    View in: PubMed
    Score: 0.161
  5. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 2002 Nov 27; 288(20):2579-88.
    View in: PubMed
    Score: 0.144
  6. Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes. Diabetes Care. 1999 Apr; 22 Suppl 3:C31-7.
    View in: PubMed
    Score: 0.112
  7. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med (Berl). 1998 Jan; 76(1):21-31.
    View in: PubMed
    Score: 0.103
  8. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med. 1996 Oct; 28(5):427-32.
    View in: PubMed
    Score: 0.094
  9. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996 Jun; 25(2):255-70.
    View in: PubMed
    Score: 0.092
  10. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest. 1995 Oct; 96(4):1759-67.
    View in: PubMed
    Score: 0.088
  11. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest. 1995 Aug; 96(2):733-40.
    View in: PubMed
    Score: 0.087
  12. A complex interplay of factors causes diabetic nephropathy. Metabolism. 2011 May; 60(5):591-3.
    View in: PubMed
    Score: 0.063
  13. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.050
  14. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
    Score: 0.049
  15. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
    Score: 0.049
  16. Hyperglycemia and the pathogenesis of diabetic retinopathy. J Gen Intern Med. 1986 Mar-Apr; 1(2):133-4.
    View in: PubMed
    Score: 0.045
  17. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 2004 Jul 06; 110(1):7-9.
    View in: PubMed
    Score: 0.040
  18. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74.
    View in: PubMed
    Score: 0.040
  19. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.029
  20. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. 1999 Sep; 45(2-3):183-90.
    View in: PubMed
    Score: 0.029
  21. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.028
  22. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun; 47(6):859-66.
    View in: PubMed
    Score: 0.026
  23. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.026
  24. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.025
  25. Vascular dysfunction in diabetes mellitus. Lancet. 1997 Jul; 350 Suppl 1:SI9-13.
    View in: PubMed
    Score: 0.025
  26. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med. 1994; 45:179-88.
    View in: PubMed
    Score: 0.019
  27. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
    Score: 0.014
  28. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. J Clin Invest. 1989 Jan; 83(1):127-36.
    View in: PubMed
    Score: 0.014
  29. Cell biology as an approach to the study of the vascular complications of diabetes. Metabolism. 1985 Dec; 34(12 Suppl 1):17-22.
    View in: PubMed
    Score: 0.011
  30. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8.
    View in: PubMed
    Score: 0.010
  31. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes. 2002 Sep; 51(9):2804-10.
    View in: PubMed
    Score: 0.009
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.