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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Enzyme Activation.
Connection Strength

1.411
  1. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.118
  2. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167.
    View in: PubMed
    Score: 0.107
  3. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
    Score: 0.080
  4. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74.
    View in: PubMed
    Score: 0.074
  5. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
    Score: 0.072
  6. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.064
  7. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
    View in: PubMed
    Score: 0.058
  8. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.053
  9. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
    Score: 0.052
  10. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20.
    View in: PubMed
    Score: 0.051
  11. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5.
    View in: PubMed
    Score: 0.049
  12. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8.
    View in: PubMed
    Score: 0.048
  13. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.039
  14. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.038
  15. B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol. 2002 Aug 20; 12(16):R554-6.
    View in: PubMed
    Score: 0.038
  16. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
    View in: PubMed
    Score: 0.033
  17. Protein kinase C and myocardial biology and function. Circ Res. 2000 Jun 09; 86(11):1104-6.
    View in: PubMed
    Score: 0.032
  18. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000; 5(3):173-85.
    View in: PubMed
    Score: 0.032
  19. Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes. Diabetes Care. 1999 Apr; 22 Suppl 3:C31-7.
    View in: PubMed
    Score: 0.030
  20. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Perit Dial Int. 1999; 19 Suppl 2:S222-7.
    View in: PubMed
    Score: 0.029
  21. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun; 47(6):859-66.
    View in: PubMed
    Score: 0.028
  22. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med (Berl). 1998 Jan; 76(1):21-31.
    View in: PubMed
    Score: 0.027
  23. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998; 7(1-2):69-76.
    View in: PubMed
    Score: 0.027
  24. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.027
  25. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.025
  26. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.025
  27. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.024
  28. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest. 1995 Aug; 96(2):733-40.
    View in: PubMed
    Score: 0.023
  29. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994 Nov; 43(11):1372-7.
    View in: PubMed
    Score: 0.022
  30. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-1515.
    View in: PubMed
    Score: 0.019
  31. Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells. Biochem Biophys Res Commun. 1989 Jul 14; 162(1):381-6.
    View in: PubMed
    Score: 0.015
  32. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.015
  33. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42.
    View in: PubMed
    Score: 0.011
  34. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.009
  35. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation. 1999 Jan 26; 99(3):384-91.
    View in: PubMed
    Score: 0.007
  36. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2165-76.
    View in: PubMed
    Score: 0.006
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.