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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Endothelium, Vascular.
Connection Strength

2.487
  1. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):92-101.
    View in: PubMed
    Score: 0.279
  2. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium. Circ Res. 2013 Aug 02; 113(4):418-27.
    View in: PubMed
    Score: 0.205
  3. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89.
    View in: PubMed
    Score: 0.166
  4. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.165
  5. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007 Jan; 3(1):46-56.
    View in: PubMed
    Score: 0.131
  6. Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease. Heart Fail Monit. 2001; 1(3):74-82.
    View in: PubMed
    Score: 0.087
  7. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem. 2000 Dec 29; 275(52):40725-31.
    View in: PubMed
    Score: 0.087
  8. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
    View in: PubMed
    Score: 0.084
  9. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.082
  10. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.065
  11. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 2016 06; 65(6):1462-71.
    View in: PubMed
    Score: 0.063
  12. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest. 1995 Mar; 95(3):1353-62.
    View in: PubMed
    Score: 0.058
  13. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Diabetes. 1995 Jan; 44(1):98-103.
    View in: PubMed
    Score: 0.057
  14. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9.
    View in: PubMed
    Score: 0.056
  15. Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. J Dent Res. 2014 Jun; 93(6):596-601.
    View in: PubMed
    Score: 0.054
  16. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med. 1994; 45:179-88.
    View in: PubMed
    Score: 0.053
  17. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes. 1993 Jan; 42(1):80-9.
    View in: PubMed
    Score: 0.050
  18. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.049
  19. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem. 1991 Dec 05; 266(34):23251-6.
    View in: PubMed
    Score: 0.046
  20. Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C. J Biol Chem. 1990 Aug 15; 265(23):13864-70.
    View in: PubMed
    Score: 0.042
  21. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.039
  22. Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester. J Biol Chem. 1989 Apr 05; 264(10):5916-23.
    View in: PubMed
    Score: 0.038
  23. Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells. J Clin Invest. 1989 Jan; 83(1):90-4.
    View in: PubMed
    Score: 0.038
  24. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. J Clin Invest. 1989 Jan; 83(1):127-36.
    View in: PubMed
    Score: 0.038
  25. Regulation of vascular permeability in cell culture. Diabetes. 1987 Dec; 36(12):1460-7.
    View in: PubMed
    Score: 0.035
  26. Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol. 2007 May; 46(5):324-6.
    View in: PubMed
    Score: 0.033
  27. Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care. 2005 Nov; 28(11):2803-5.
    View in: PubMed
    Score: 0.030
  28. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96.
    View in: PubMed
    Score: 0.029
  29. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes. 2005 Jan; 54(1):204-11.
    View in: PubMed
    Score: 0.029
  30. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 2004 Jul 06; 110(1):7-9.
    View in: PubMed
    Score: 0.028
  31. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80.
    View in: PubMed
    Score: 0.025
  32. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
    View in: PubMed
    Score: 0.023
  33. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 1999 Sep; 48(9):1856-62.
    View in: PubMed
    Score: 0.020
  34. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.020
  35. Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Diabetes. 1998 Sep; 47(9):1480-8.
    View in: PubMed
    Score: 0.018
  36. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2165-76.
    View in: PubMed
    Score: 0.016
  37. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med. 1996 Oct; 28(5):427-32.
    View in: PubMed
    Score: 0.016
  38. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 1996 Jun; 37(7):1311-21.
    View in: PubMed
    Score: 0.016
  39. Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells. Br J Pharmacol. 1996 Mar; 117(6):1318-24.
    View in: PubMed
    Score: 0.015
  40. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.014
  41. Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6231-5.
    View in: PubMed
    Score: 0.014
  42. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.013
  43. A cell biology approach to the study of diabetic vascular complications. J Diabet Complications. 1991 Apr-Sep; 5(2-3):56-7.
    View in: PubMed
    Score: 0.011
  44. Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes. Diabetes. 1989 Dec; 38(12):1643-6.
    View in: PubMed
    Score: 0.010
  45. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol. 1989 Mar; 63(3):1318-25.
    View in: PubMed
    Score: 0.010
  46. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42.
    View in: PubMed
    Score: 0.006
  47. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
    View in: PubMed
    Score: 0.006
  48. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.
    View in: PubMed
    Score: 0.006
  49. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation. 2002 May 07; 105(18):e138-43.
    View in: PubMed
    Score: 0.006
  50. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2099-109.
    View in: PubMed
    Score: 0.004
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.