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George Liang King, M.D.

Concepts

This page shows the publications George King has written about Diabetes Mellitus, Experimental.
Connection Strength

4.337
  1. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 07; 92(1):101-113.
    View in: PubMed
    Score: 0.421
  2. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32.
    View in: PubMed
    Score: 0.312
  3. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79.
    View in: PubMed
    Score: 0.304
  4. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
    Score: 0.273
  5. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
    Score: 0.209
  6. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20.
    View in: PubMed
    Score: 0.204
  7. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.158
  8. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.153
  9. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.119
  10. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. 1998; 7(1-2):55-67.
    View in: PubMed
    Score: 0.111
  11. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998; 7(1-2):69-76.
    View in: PubMed
    Score: 0.111
  12. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.110
  13. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.107
  14. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017 Jun; 23(6):753-762.
    View in: PubMed
    Score: 0.106
  15. Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. J Am Soc Nephrol. 1997 Mar; 8(3):426-35.
    View in: PubMed
    Score: 0.104
  16. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996 Nov; 37(12):2504-18.
    View in: PubMed
    Score: 0.102
  17. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.100
  18. Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. 2016 09; 65(9):2760-71.
    View in: PubMed
    Score: 0.099
  19. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.099
  20. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest. 1995 Oct; 96(4):1759-67.
    View in: PubMed
    Score: 0.095
  21. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46.
    View in: PubMed
    Score: 0.094
  22. The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):596-607.
    View in: PubMed
    Score: 0.091
  23. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994 Nov; 43(11):1372-7.
    View in: PubMed
    Score: 0.089
  24. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.088
  25. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9.
    View in: PubMed
    Score: 0.088
  26. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.083
  27. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.078
  28. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56.
    View in: PubMed
    Score: 0.067
  29. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.061
  30. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. J Clin Invest. 1989 Jan; 83(1):127-36.
    View in: PubMed
    Score: 0.059
  31. Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. J Clin Invest. 1983 Apr; 71(4):974-9.
    View in: PubMed
    Score: 0.040
  32. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
    View in: PubMed
    Score: 0.040
  33. Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3955-62.
    View in: PubMed
    Score: 0.034
  34. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.031
  35. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor. Curr Eye Res. 1995 Sep; 14(9):741-9.
    View in: PubMed
    Score: 0.024
  36. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):981-90.
    View in: PubMed
    Score: 0.021
  37. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Curr Eye Res. 1992 Apr; 11(4):287-95.
    View in: PubMed
    Score: 0.019
  38. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.
    View in: PubMed
    Score: 0.017
  39. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74.
    View in: PubMed
    Score: 0.011
  40. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar; 14(3):439-47.
    View in: PubMed
    Score: 0.008
Connection Strength

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.