Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit functionaility are currrently unavailable.

George Liang King, M.D.

Concepts

This page shows the publications George King has written about Animals.
Connection Strength

0.928
  1. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nat Commun. 2019 09 27; 10(1):4427.
    View in: PubMed
    Score: 0.021
  2. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 07 03; 11(499).
    View in: PubMed
    Score: 0.021
  3. Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. J Mol Med (Berl). 2018 05; 96(5):373-381.
    View in: PubMed
    Score: 0.019
  4. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):92-101.
    View in: PubMed
    Score: 0.019
  5. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167.
    View in: PubMed
    Score: 0.018
  6. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017 Jun; 23(6):753-762.
    View in: PubMed
    Score: 0.018
  7. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 07; 92(1):101-113.
    View in: PubMed
    Score: 0.018
  8. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. 2017 03; 60(3):585-596.
    View in: PubMed
    Score: 0.017
  9. Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. 2016 09; 65(9):2760-71.
    View in: PubMed
    Score: 0.017
  10. PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest. 2016 Mar 01; 126(3):837-53.
    View in: PubMed
    Score: 0.016
  11. Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. J Dent Res. 2014 Jun; 93(6):596-601.
    View in: PubMed
    Score: 0.015
  12. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
    Score: 0.014
  13. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium. Circ Res. 2013 Aug 02; 113(4):418-27.
    View in: PubMed
    Score: 0.014
  14. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32.
    View in: PubMed
    Score: 0.013
  15. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79.
    View in: PubMed
    Score: 0.013
  16. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74.
    View in: PubMed
    Score: 0.013
  17. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31.
    View in: PubMed
    Score: 0.013
  18. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
    Score: 0.012
  19. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
    Score: 0.012
  20. A complex interplay of factors causes diabetic nephropathy. Metabolism. 2011 May; 60(5):591-3.
    View in: PubMed
    Score: 0.011
  21. Diabetes: Podocytes lose their footing. Nature. 2010 Nov 04; 468(7320):42-4.
    View in: PubMed
    Score: 0.011
  22. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89.
    View in: PubMed
    Score: 0.011
  23. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
    Score: 0.011
  24. Kidney complications: factors that protect the diabetic vasculature. Nat Med. 2010 Jan; 16(1):40-1.
    View in: PubMed
    Score: 0.011
  25. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306.
    View in: PubMed
    Score: 0.011
  26. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
    View in: PubMed
    Score: 0.010
  27. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.
    View in: PubMed
    Score: 0.010
  28. More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):608-10.
    View in: PubMed
    Score: 0.010
  29. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):919-24.
    View in: PubMed
    Score: 0.010
  30. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5750-5.
    View in: PubMed
    Score: 0.009
  31. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53.
    View in: PubMed
    Score: 0.009
  32. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
    Score: 0.009
  33. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
    Score: 0.009
  34. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20.
    View in: PubMed
    Score: 0.009
  35. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J. 2006 Oct; 20(12):2058-67.
    View in: PubMed
    Score: 0.009
  36. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5.
    View in: PubMed
    Score: 0.008
  37. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8.
    View in: PubMed
    Score: 0.008
  38. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
    View in: PubMed
    Score: 0.008
  39. Molecular targets of diabetic cardiovascular complications. Curr Drug Targets. 2005 Jun; 6(4):487-94.
    View in: PubMed
    Score: 0.008
  40. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26.
    View in: PubMed
    Score: 0.008
  41. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96.
    View in: PubMed
    Score: 0.008
  42. Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci. 2004 Dec; 1031:204-13.
    View in: PubMed
    Score: 0.008
  43. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol. 2004 Oct; 122(4):333-8.
    View in: PubMed
    Score: 0.007
  44. Microvascular complications of diabetes. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):215-38, xi-xii.
    View in: PubMed
    Score: 0.007
  45. Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol. 2003 Aug; 14(8 Suppl 3):S216-20.
    View in: PubMed
    Score: 0.007
  46. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71.
    View in: PubMed
    Score: 0.007
  47. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
    View in: PubMed
    Score: 0.007
  48. Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol. 2003; 233:397-422.
    View in: PubMed
    Score: 0.007
  49. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
    View in: PubMed
    Score: 0.006
  50. B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol. 2002 Aug 20; 12(16):R554-6.
    View in: PubMed
    Score: 0.006
  51. Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):503-9.
    View in: PubMed
    Score: 0.006
  52. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002 Jan 22; 105(3):373-9.
    View in: PubMed
    Score: 0.006
  53. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
    View in: PubMed
    Score: 0.006
  54. Protein kinase C and the development of diabetic vascular complications. Diabet Med. 2001 Dec; 18(12):945-59.
    View in: PubMed
    Score: 0.006
  55. Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease. Heart Fail Monit. 2001; 1(3):74-82.
    View in: PubMed
    Score: 0.006
  56. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem. 2000 Dec 29; 275(52):40725-31.
    View in: PubMed
    Score: 0.006
  57. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
    View in: PubMed
    Score: 0.006
  58. Protein kinase C and myocardial biology and function. Circ Res. 2000 Jun 09; 86(11):1104-6.
    View in: PubMed
    Score: 0.006
  59. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000 May; 21(5):181-7.
    View in: PubMed
    Score: 0.006
  60. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
    View in: PubMed
    Score: 0.005
  61. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med. 2000; 5(3):173-85.
    View in: PubMed
    Score: 0.005
  62. Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. FASEB J. 1999 Dec; 13(15):2329-37.
    View in: PubMed
    Score: 0.005
  63. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Res Clin Pract. 1999 Sep; 45(2-3):169-82.
    View in: PubMed
    Score: 0.005
  64. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. 1999 Sep; 45(2-3):183-90.
    View in: PubMed
    Score: 0.005
  65. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest. 1999 Aug; 104(4):447-57.
    View in: PubMed
    Score: 0.005
  66. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.
    View in: PubMed
    Score: 0.005
  67. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
    View in: PubMed
    Score: 0.005
  68. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Perit Dial Int. 1999; 19 Suppl 2:S222-7.
    View in: PubMed
    Score: 0.005
  69. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun; 47(6):859-66.
    View in: PubMed
    Score: 0.005
  70. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med (Berl). 1998 Jan; 76(1):21-31.
    View in: PubMed
    Score: 0.005
  71. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. 1998; 7(1-2):55-67.
    View in: PubMed
    Score: 0.005
  72. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998; 7(1-2):69-76.
    View in: PubMed
    Score: 0.005
  73. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20.
    View in: PubMed
    Score: 0.005
  74. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80.
    View in: PubMed
    Score: 0.005
  75. Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9320-5.
    View in: PubMed
    Score: 0.005
  76. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997 Jul 01; 100(1):115-26.
    View in: PubMed
    Score: 0.005
  77. Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. J Am Soc Nephrol. 1997 Mar; 8(3):426-35.
    View in: PubMed
    Score: 0.004
  78. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996 Nov 01; 98(9):2018-26.
    View in: PubMed
    Score: 0.004
  79. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996 Nov; 37(12):2504-18.
    View in: PubMed
    Score: 0.004
  80. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 1996 Jul; 45 Suppl 3:S105-8.
    View in: PubMed
    Score: 0.004
  81. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996 Jul; 45 Suppl 3:S117-9.
    View in: PubMed
    Score: 0.004
  82. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31.
    View in: PubMed
    Score: 0.004
  83. Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression. Contrib Nephrol. 1996; 118:180-7.
    View in: PubMed
    Score: 0.004
  84. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest. 1995 Oct; 96(4):1759-67.
    View in: PubMed
    Score: 0.004
  85. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest. 1995 Aug; 96(2):733-40.
    View in: PubMed
    Score: 0.004
  86. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46.
    View in: PubMed
    Score: 0.004
  87. PKC-ß activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis. Cardiovasc Res. 2015 May 01; 106(2):303-13.
    View in: PubMed
    Score: 0.004
  88. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest. 1995 Mar; 95(3):1353-62.
    View in: PubMed
    Score: 0.004
  89. The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):596-607.
    View in: PubMed
    Score: 0.004
  90. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Diabetes. 1995 Jan; 44(1):98-103.
    View in: PubMed
    Score: 0.004
  91. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994 Nov; 43(11):1372-7.
    View in: PubMed
    Score: 0.004
  92. Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. Biochem J. 1994 Oct 01; 303 ( Pt 1):43-50.
    View in: PubMed
    Score: 0.004
  93. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994 Sep; 267(3 Pt 1):E369-79.
    View in: PubMed
    Score: 0.004
  94. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9.
    View in: PubMed
    Score: 0.004
  95. Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6231-5.
    View in: PubMed
    Score: 0.004
  96. Glucose induced genes in bovine aortic smooth muscle cells identified by mRNA differential display. FASEB J. 1994 Jan; 8(1):103-6.
    View in: PubMed
    Score: 0.004
  97. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993 Nov; 265(5 Pt 1):E783-93.
    View in: PubMed
    Score: 0.004
  98. Characterization of type I IGF receptor and IGF-I mRNA expression in cultured human and bovine glomerular cells. Regul Pept. 1993 Oct 20; 48(1-2):9-20.
    View in: PubMed
    Score: 0.004
  99. SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One. 2013; 8(2):e56681.
    View in: PubMed
    Score: 0.003
  100. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes. 1993 Jan; 42(1):80-9.
    View in: PubMed
    Score: 0.003
  101. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-1515.
    View in: PubMed
    Score: 0.003
  102. Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes. Diabetes. 1992 Dec; 41(12):1533-9.
    View in: PubMed
    Score: 0.003
  103. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11059-63.
    View in: PubMed
    Score: 0.003
  104. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Curr Eye Res. 1992 Apr; 11(4):287-95.
    View in: PubMed
    Score: 0.003
  105. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem. 1991 Dec 05; 266(34):23251-6.
    View in: PubMed
    Score: 0.003
  106. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.
    View in: PubMed
    Score: 0.003
  107. A cell biology approach to the study of diabetic vascular complications. J Diabet Complications. 1991 Apr-Sep; 5(2-3):56-7.
    View in: PubMed
    Score: 0.003
  108. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56.
    View in: PubMed
    Score: 0.003
  109. Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C. J Biol Chem. 1990 Aug 15; 265(23):13864-70.
    View in: PubMed
    Score: 0.003
  110. Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes. Diabetes. 1989 Dec; 38(12):1643-6.
    View in: PubMed
    Score: 0.003
  111. Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Mol Endocrinol. 1989 Aug; 3(8):1183-90.
    View in: PubMed
    Score: 0.003
  112. Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells. Biochem Biophys Res Commun. 1989 Jul 14; 162(1):381-6.
    View in: PubMed
    Score: 0.003
  113. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc Natl Acad Sci U S A. 1989 07; 86(13):5141-5.
    View in: PubMed
    Score: 0.003
  114. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
    Score: 0.003
  115. Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester. J Biol Chem. 1989 Apr 05; 264(10):5916-23.
    View in: PubMed
    Score: 0.003
  116. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72.
    View in: PubMed
    Score: 0.003
  117. Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells. J Clin Invest. 1989 Jan; 83(1):90-4.
    View in: PubMed
    Score: 0.003
  118. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. J Clin Invest. 1989 Jan; 83(1):127-36.
    View in: PubMed
    Score: 0.003
  119. Intracellular pathways of insulin transport across vascular endothelial cells. Am J Physiol. 1988 Oct; 255(4 Pt 1):C459-64.
    View in: PubMed
    Score: 0.002
  120. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6998-7003.
    View in: PubMed
    Score: 0.002
  121. Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells. Am J Physiol. 1988 Mar; 254(3 Pt 1):C411-6.
    View in: PubMed
    Score: 0.002
  122. A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes. J Exp Med. 1988 Mar 01; 167(3):1003-15.
    View in: PubMed
    Score: 0.002
  123. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34.
    View in: PubMed
    Score: 0.002
  124. Regulation of vascular permeability in cell culture. Diabetes. 1987 Dec; 36(12):1460-7.
    View in: PubMed
    Score: 0.002
  125. Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol. 1987 Oct; 105(4):1595-601.
    View in: PubMed
    Score: 0.002
  126. Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol Chem. 1987 May 05; 262(13):6417-24.
    View in: PubMed
    Score: 0.002
  127. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
    Score: 0.002
  128. Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol. 2007 May; 46(5):324-6.
    View in: PubMed
    Score: 0.002
  129. Processing and release of insulin and insulin-like growth factor I by macro- and microvascular endothelial cells. Endocrinology. 1986 Nov; 119(5):1904-13.
    View in: PubMed
    Score: 0.002
  130. Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells. Diabetes. 1986 Oct; 35(10):1065-72.
    View in: PubMed
    Score: 0.002
  131. Characterization of the receptors for insulin and the insulin-like growth factors on micro- and macrovascular tissues. Endocrinology. 1985 Sep; 117(3):1222-9.
    View in: PubMed
    Score: 0.002
  132. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42.
    View in: PubMed
    Score: 0.002
  133. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest. 1985 Mar; 75(3):1028-36.
    View in: PubMed
    Score: 0.002
  134. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8.
    View in: PubMed
    Score: 0.002
  135. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74.
    View in: PubMed
    Score: 0.002
  136. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42.
    View in: PubMed
    Score: 0.002
  137. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80.
    View in: PubMed
    Score: 0.002
  138. Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. J Clin Invest. 1983 Apr; 71(4):974-9.
    View in: PubMed
    Score: 0.002
  139. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
    View in: PubMed
    Score: 0.002
  140. Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1983 Mar; 80(5):1308-12.
    View in: PubMed
    Score: 0.002
  141. Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes. J Biol Chem. 1982 Sep 10; 257(17):10001-6.
    View in: PubMed
    Score: 0.002
  142. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes. 2002 Sep; 51(9):2804-10.
    View in: PubMed
    Score: 0.002
  143. Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo. Hypertension. 2001 Dec 01; 38(6):1260-5.
    View in: PubMed
    Score: 0.002
  144. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5.
    View in: PubMed
    Score: 0.002
  145. Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem. 2002 Jan 11; 277(2):1047-57.
    View in: PubMed
    Score: 0.002
  146. Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3955-62.
    View in: PubMed
    Score: 0.001
  147. Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest. 1980 Jul; 66(1):130-40.
    View in: PubMed
    Score: 0.001
  148. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J. 2000 Mar; 14(3):439-47.
    View in: PubMed
    Score: 0.001
  149. Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Diabetes. 1998 Sep; 47(9):1480-8.
    View in: PubMed
    Score: 0.001
  150. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
    View in: PubMed
    Score: 0.001
  151. In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest. 1998 Jul 01; 102(1):72-8.
    View in: PubMed
    Score: 0.001
  152. Vascular endothelial growth factor expression in canine peripheral vein bypass grafts. J Vasc Surg. 1997 Jul; 26(1):79-86.
    View in: PubMed
    Score: 0.001
  153. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2165-76.
    View in: PubMed
    Score: 0.001
  154. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2099-109.
    View in: PubMed
    Score: 0.001
  155. Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes. 1996 Aug; 45(8):1016-23.
    View in: PubMed
    Score: 0.001
  156. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 1996 Jun; 37(7):1311-21.
    View in: PubMed
    Score: 0.001
  157. Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells. Br J Pharmacol. 1996 Mar; 117(6):1318-24.
    View in: PubMed
    Score: 0.001
  158. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10457-61.
    View in: PubMed
    Score: 0.001
  159. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor. Curr Eye Res. 1995 Sep; 14(9):741-9.
    View in: PubMed
    Score: 0.001
  160. Isolation of genes differentially expressed at the downstream anastomosis of prosthetic arterial grafts with use of mRNA differential display. J Vasc Surg. 1995 Feb; 21(2):228-34.
    View in: PubMed
    Score: 0.001
  161. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):981-90.
    View in: PubMed
    Score: 0.001
  162. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J Biol Chem. 1993 May 25; 268(15):11256-64.
    View in: PubMed
    Score: 0.001
  163. Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex. Kidney Int. 1992 Jun; 41(6):1638-45.
    View in: PubMed
    Score: 0.001
  164. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol. 1989 Mar; 63(3):1318-25.
    View in: PubMed
    Score: 0.001
  165. Processing of insulin by bovine endothelial cells in culture. Internalization without degradation. Diabetes. 1984 Aug; 33(8):794-800.
    View in: PubMed
    Score: 0.000
  166. [B17-D-leucine]insulin and [B17-norleucine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1983 Nov; 364(11):1615-26.
    View in: PubMed
    Score: 0.000
  167. [B22-D-arginine]insulin: synthesis and biological properties. Hoppe Seylers Z Physiol Chem. 1982 Dec; 363(12):1449-60.
    View in: PubMed
    Score: 0.000
  168. Demonstration of receptors for insulin and insulin-like growth factors on Swarm rat chondrosarcoma chondrocytes. Evidence that insulin stimulates proteoglycan synthesis through the insulin receptor. J Biol Chem. 1982 Jan 25; 257(2):663-9.
    View in: PubMed
    Score: 0.000
  169. Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res. 1981; 37:477-538.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.