Harvard Catalyst Profiles

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George Liang King, M.D.

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Other Positions
Title
Institution
Department

Mentoring
Role of Insulin and PKC activation in monocytes differentiation and the development of atherosclerosis
Summer, 06/20/05 - 09/01/05

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP3DK112192 (KING, GEORGE L) Sep 30, 2016 - Sep 29, 2019
    NIH/NIDDK
    Pyruvate kinase M2 levels and activation as protective factors for diabetic nephropathy
    Role: Co-Principal Investigator
  2. R01EY026080 (KING, GEORGE L) Mar 1, 2016 - Feb 28, 2019
    NIH/NEI
    Identification of Retinoid-Binding Protein 3 (RBP3): A Protective Factor against Diabetic Retinopathy Using Retina from People with Extreme Duration of Diabetes
    Role: Principal Investigator
  3. DP3DK094333 (KING, GEORGE L) Sep 30, 2011 - Jun 30, 2016
    NIH/NIDDK
    Validation of Potential Protective Factors from Diabetic Complications
    Role: Principal Investigator
  4. R24DK090961 (KING, GEORGE L) Sep 30, 2010 - Aug 31, 2013
    NIH/NIDDK
    Protective Factors Against the Development of Microvascular Complications
    Role: Principal Investigator
  5. R24DK083957 (KING, GEORGE L) Aug 1, 2009 - Jul 31, 2011
    NIH/NIDDK
    Biomarkers for protection against complications and beta-cell destruction
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 Jul 03; 11(499). PMID: 31270273.
    Citations:    
  2. Yu MG, Keenan HA, Shah HS, Frodsham SG, Pober D, He Z, Wolfson EA, D'Eon S, Tinsley LJ, Bonner-Weir S, Pezzolesi MG, King GL. Residual ß cell function and monogenic variants in long-duration type 1 diabetes patients. J Clin Invest. 2019 Jul 02; 130. PMID: 31264968.
    Citations:    
  3. Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL. Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration. J Periodontol. 2019 Jun; 90(6):565-575. PMID: 31026349.
    Citations:    
  4. Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL. Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Diabetes Care. 2019 Jul; 42(7):1263-1273. PMID: 31076418.
    Citations:    
  5. Gordin D, King GL. Response to Comment on Gordin et al. Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 2018;41:815-822. Diabetes Care. 2018 07; 41(7):e128. PMID: 29934489.
    Citations:    Fields:    Translation:Humans
  6. Musen G, Tinsley LJ, Marcinkowski KA, Pober D, Sun JK, Khatri M, Huynh R, Lu A, King GL, Keenan HA. Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications. Diabetes Care. 2018 08; 41(8):1749-1756. PMID: 29871904.
    Citations:    Fields:    Translation:Humans
  7. Qi W, Li Q, Gordin D, King GL. Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. J Mol Med (Berl). 2018 05; 96(5):373-381. PMID: 29574544.
    Citations:    Fields:    
  8. Mima A, Yasuzawa T, King GL, Ueshima S. Obesity-associated glomerular inflammation increases albuminuria without renal histological changes. FEBS Open Bio. 2018 04; 8(4):664-670. PMID: 29632818.
    Citations:    
  9. Roshandel D, Gubitosi-Klug R, Bull SB, Canty AJ, Pezzolesi MG, King GL, Keenan HA, Snell-Bergeon JK, Maahs DM, Klein R, Klein BEK, Orchard TJ, Costacou T, Weedon MN, Oram RA, Paterson AD. Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia. 2018 05; 61(5):1098-1111. PMID: 29404672.
    Citations: 1     Fields:    Translation:HumansCells
  10. Gordin D, Harjutsalo V, Tinsley L, Fickweiler W, Sun JK, Forsblom C, Amenta PS, Pober D, D'Eon S, Khatri M, Stillman IE, Groop PH, Keenan HA, King GL. Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care. 2018 04; 41(4):815-822. PMID: 29386250.
    Citations:    Fields:    Translation:Humans
  11. Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, Vinik AI, Casellini CM. Diabetic Microvascular Disease: An Endocrine Society Scientific Statement. J Clin Endocrinol Metab. 2017 12 01; 102(12):4343-4410. PMID: 29126250.
    Citations: 7     Fields:    Translation:Humans
  12. Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):92-101. PMID: 29162603.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Tinsley LJ, Kupelian V, D'Eon SA, Pober D, Sun JK, King GL, Keenan HA. Association of Glycemic Control With Reduced Risk for Large-Vessel Disease After More Than 50 Years of Type 1 Diabetes. J Clin Endocrinol Metab. 2017 10 01; 102(10):3704-3711. PMID: 28973526.
    Citations: 2     Fields:    Translation:Humans
  14. Maddaloni E, Xia Y, Park K, D'Eon S, Tinsley LJ, St-Louis R, Khamaisi M, Li Q, King GL, Keenan HA. High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes. Cardiovasc Diabetol. 2017 09 16; 16(1):116. PMID: 28915881.
    Citations: 1     Fields:    Translation:HumansCells
  15. Li Q, Park K, Xia Y, Matsumoto M, Qi W, Fu J, Yokomizo H, Khamaisi M, Wang X, Rask-Madsen C, King GL. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167. PMID: 28855204.
    Citations:    Fields:    Translation:AnimalsCells
  16. Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017 Jun; 23(6):753-762. PMID: 28436957.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  17. Noh H, Yu MR, Kim HJ, Lee JH, Park BW, Wu IH, Matsumoto M, King GL. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 07; 92(1):101-113. PMID: 28396116.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Rask-Madsen C, Park K, Li Q, King GL. Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circ Res. 2017 02 17; 120(4):e2-e3. PMID: 28209799.
    Citations:    Fields:    
  19. Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, King GL. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. 2017 03; 60(3):585-596. PMID: 27933336.
    Citations:    Fields:    Translation:HumansAnimalsCells
  20. King GL, Park K, Li Q. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 2016 06; 65(6):1462-71. PMID: 27222390.
    Citations: 16     Fields:    Translation:HumansCells
  21. Katagiri S, Park K, Maeda Y, Rao TN, Khamaisi M, Li Q, Yokomizo H, Mima A, Lancerotto L, Wagers A, Orgill DP, King GL. Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. 2016 09; 65(9):2760-71. PMID: 27217486.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, King GL. Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight. 2016 May 05; 1(6). PMID: 27200419.
    Citations: 4     Fields:    
  23. Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL. PKCd inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest. 2016 Mar 01; 126(3):837-53. PMID: 26808499.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933.
    Citations: 9     Fields:    Translation:HumansCells
  25. Agarwal I, Glazer NL, Barasch E, Djousse L, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, Siscovick DS, King GL, Mukamal KJ. Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study. Metabolism. 2015 Oct; 64(10):1316-23. PMID: 26282733.
    Citations: 1     Fields:    Translation:Humans
  26. He ZH, D'Eon SA, Tinsley LJ, Fitzgerald S, Hastings SM, Khamaisi M, Sun JK, Turek SJ, Schaefer EJ, King GL, Keenan HA. Cardiovascular disease protection in long-duration type 1 diabetes and sex differences. Diabetes Care. 2015 May; 38(5):e73-4. PMID: 25908159.
    Citations: 3     Fields:    Translation:Humans
  27. Durpès MC, Morin C, Paquin-Veillet J, Beland R, Paré M, Guimond MO, Rekhter M, King GL, Geraldes P. PKC-ß activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis. Cardiovasc Res. 2015 May 01; 106(2):303-13. PMID: 25808972.
    Citations: 8     Fields:    Translation:AnimalsCells
  28. Hsu WC, Lau KH, Matsumoto M, Moghazy D, Keenan H, King GL. Improvement of insulin sensitivity by isoenergy high carbohydrate traditional Asian diet: a randomized controlled pilot feasibility study. PLoS One. 2014; 9(9):e106851. PMID: 25226279.
    Citations: 2     Fields:    Translation:HumansCells
  29. Kondo K, Ishikado A, Morino K, Nishio Y, Ugi S, Kajiwara S, Kurihara M, Iwakawa H, Nakao K, Uesaki S, Shigeta Y, Imanaka H, Yoshizaki T, Sekine O, Makino T, Maegawa H, King GL, Kashiwagi A. A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study. Nutr Res. 2014 Jun; 34(6):491-8. PMID: 25026916.
    Citations: 8     Fields:    Translation:Humans
  30. Hernandez SL, Gong JH, Chen L, Wu IH, Sun JK, Keenan HA, King GL. Characterization of circulating and endothelial progenitor cells in patients with extreme-duration type 1 diabetes. Diabetes Care. 2014 Aug; 37(8):2193-201. PMID: 24780357.
    Citations: 11     Fields:    Translation:HumansCells
  31. Mizutani K, Park K, Mima A, Katagiri S, King GL. Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. J Dent Res. 2014 Jun; 93(6):596-601. PMID: 24744283.
    Citations: 5     Fields:    Translation:AnimalsCells
  32. Turek SJ, Hastings SM, Sun JK, King GL, Keenan HA. Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care. 2013 Oct; 36(10):3222-6. PMID: 23780949.
    Citations: 5     Fields:    Translation:Humans
  33. Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41. PMID: 23775122.
    Citations: 17     Fields:    Translation:AnimalsCells
  34. Le H, Wong S, Iftikar T, Keenan H, King GL, Hsu WC. Characterization of factors affecting attainment of glycemic control in Asian Americans with diabetes in a culturally specific program. Diabetes Educ. 2013 Jul-Aug; 39(4):468-77. PMID: 23771841.
    Citations:    Fields:    Translation:Humans
  35. Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium. Circ Res. 2013 Aug 02; 113(4):418-27. PMID: 23759514.
    Citations: 27     Fields:    Translation:AnimalsCells
  36. Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y. SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One. 2013; 8(2):e56681. PMID: 23451068.
    Citations: 4     Fields:    Translation:AnimalsCells
  37. Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab. 2013 Jan 08; 17(1):20-33. PMID: 23312281.
    Citations: 80     Fields:    Translation:Humans
  38. Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Keith Blackwell T, Makino T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-1515. PMID: 23277146.
    Citations: 11     Fields:    Translation:AnimalsCells
  39. Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32. PMID: 23197686.
    Citations: 7     Fields:    Translation:Animals
  40. Mima A, Qi W, King GL. Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol. 2012 Sep; 32(5):471-8. PMID: 23062988.
    Citations: 5     Fields:    Translation:Humans
  41. Glazer NL, Macy EM, Lumley T, Smith NL, Reiner AP, Psaty BM, King GL, Tracy RP, Siscovick DS. Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study. Cytokine. 2012 Nov; 60(2):341-5. PMID: 22878343.
    Citations: 5     Fields:    Translation:Humans
  42. Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79. PMID: 22826029.
    Citations: 37     Fields:    Translation:AnimalsCells
  43. Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R. Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care. 2012 May; 35(5):1189-98. PMID: 22517940.
    Citations: 17     Fields:    Translation:Humans
  44. King GL, McNeely MJ, Thorpe LE, Mau ML, Ko J, Liu LL, Sun A, Hsu WC, Chow EA. Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders. Diabetes Care. 2012 May; 35(5):1181-8. PMID: 22517939.
    Citations: 40     Fields:    Translation:Humans
  45. Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74. PMID: 22499584.
    Citations: 14     Fields:    Translation:AnimalsCells
  46. Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31. PMID: 22426129.
    Citations: 9     Fields:    Translation:AnimalsCells
  47. Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30. PMID: 22158866.
    Citations: 17     Fields:    Translation:AnimalsCells
  48. Hsu WC, Okeke E, Cheung S, Keenan H, Tsui T, Cheng K, King GL. A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One. 2011; 6(12):e28311. PMID: 22164267.
    Citations: 6     Fields:    Translation:Humans
  49. Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17. PMID: 21576825.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  50. Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care. 2011 Apr; 34(4):968-74. PMID: 21447665.
    Citations: 56     Fields:    Translation:Humans
  51. Rask-Madsen C, King GL. Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab. 2011 Mar 02; 13(3):236-8. PMID: 21356512.
    Citations: 4     Fields:    
  52. Jeong IK, King GL. New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J. 2011 Feb; 35(1):8-11. PMID: 21537407.
    Citations: 10     
  53. Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96. PMID: 21228767.
    Citations: 39     Fields:    Translation:AnimalsCells
  54. Stanton RC, King GL. A complex interplay of factors causes diabetic nephropathy. Metabolism. 2011 May; 60(5):591-3. PMID: 21109270.
    Citations: 2     Fields:    Translation:HumansAnimals
  55. Rask-Madsen C, King GL. Diabetes: Podocytes lose their footing. Nature. 2010 Nov 04; 468(7320):42-4. PMID: 21048754.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Cao L, Arany PR, Kim J, Rivera-Feliciano J, Wang YS, He Z, Rask-Madsen C, King GL, Mooney DJ. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56. PMID: 20800279.
    Citations: 10     Fields:    Translation:AnimalsCells
  57. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53. PMID: 20699420.
    Citations: 115     Fields:    Translation:HumansCells
  58. Kitada M, Zhang Z, Mima A, King GL. Molecular mechanisms of diabetic vascular complications. J Diabetes Investig. 2010 Jun 01; 1(3):77-89. PMID: 24843412.
    Citations: 24     Fields:    
  59. Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89. PMID: 20444418.
    Citations: 93     Fields:    Translation:AnimalsCells
  60. Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31. PMID: 20431074.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  61. Rask-Madsen C, King GL. Kidney complications: factors that protect the diabetic vasculature. Nat Med. 2010 Jan; 16(1):40-1. PMID: 20057426.
    Citations: 12     Fields:    Translation:HumansAnimals
  62. King GL, Das-Evcimen N. Role of protein kinase C in diabetic complications. Expert Rev Endocrinol Metab. 2010 Jan; 5(1):77-88. PMID: 30934385.
    Citations:    
  63. Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306. PMID: 19881493.
    Citations: 131     Fields:    Translation:AnimalsCells
  64. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90. PMID: 19407223.
    Citations: 11     Fields:    Translation:AnimalsCells
  65. Rigor DL, Bodyak N, Bae S, Choi JH, Zhang L, Ter-Ovanesyan D, He Z, McMullen JR, Shioi T, Izumo S, King GL, Kang PM. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72. PMID: 19122165.
    Citations: 9     Fields:    Translation:AnimalsCells
  66. Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36. PMID: 18854316.
    Citations: 22     Fields:    Translation:AnimalsCells
  67. Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43. PMID: 19008912.
    Citations: 4     Fields:    Translation:AnimalsCells
  68. King GL. The role of inflammatory cytokines in diabetes and its complications. J Periodontol. 2008 Aug; 79(8 Suppl):1527-34. PMID: 18673007.
    Citations: 114     Fields:    Translation:Humans
  69. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6998-7003. PMID: 18458324.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  70. Rask-Madsen C, King GL. More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):608-10. PMID: 18354093.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  71. Rask-Madsen C, King GL. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):919-24. PMID: 18323518.
    Citations: 24     Fields:    Translation:AnimalsCells
  72. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34. PMID: 18249172.
    Citations: 159     Fields:    Translation:Animals
  73. Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5750-5. PMID: 18055828.
    Citations: 2     Fields:    Translation:AnimalsCells
  74. Noh H, King GL. The role of protein kinase C activation in diabetic nephropathy. Kidney Int Suppl. 2007 Aug; (106):S49-53. PMID: 17653211.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  75. Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 2007 Aug; 30(8):1995-7. PMID: 17507696.
    Citations: 37     Fields:    Translation:Humans
  76. Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510. PMID: 17574431.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  77. Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20. PMID: 17363743.
    Citations: 24     Fields:    Translation:AnimalsCells
  78. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8. PMID: 17360984.
    Citations: 75     Fields:    Translation:AnimalsCells
  79. Rask-Madsen C, King GL. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007 Jan; 3(1):46-56. PMID: 17179929.
    Citations: 123     Fields:    Translation:HumansCells
  80. Engelgau MM, Vinicor F, Simionescu M, King GL, Meininger C, Mensah GA. Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol. 2007 May; 46(5):324-6. PMID: 17275418.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  81. McGill JB, King GL, Berg PH, Price KL, Kles KA, Bastyr EJ, Hyslop DL. Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin. Expert Opin Drug Saf. 2006 Nov; 5(6):835-45. PMID: 17044810.
    Citations: 7     Fields:    Translation:Humans
  82. Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20. PMID: 17065350.
    Citations: 53     Fields:    Translation:AnimalsCells
  83. Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J. 2006 Oct; 20(12):2058-67. PMID: 17012258.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  84. Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5. PMID: 16672634.
    Citations: 28     Fields:    Translation:AnimalsCells
  85. Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8. PMID: 16505232.
    Citations: 62     Fields:    Translation:AnimalsCells
  86. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93. PMID: 16469952.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  87. Hsu WC, Cheung S, Ong E, Wong K, Lin S, Leon K, Weinger K, King GL. Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes. Diabetes Care. 2006 Feb; 29(2):415-6. PMID: 16443897.
    Citations: 10     Fields:    Translation:Humans
  88. He Z, King GL. Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care. 2005 Nov; 28(11):2803-5. PMID: 16249561.
    Citations: 2     Fields:    Translation:Humans
  89. Ahmad FK, He Z, King GL. Molecular targets of diabetic cardiovascular complications. Curr Drug Targets. 2005 Jun; 6(4):487-94. PMID: 16026267.
    Citations: 18     Fields:    Translation:HumansAnimals
  90. Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42. PMID: 15840586.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Xu Y, He Z, King GL. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep. 2005 Apr; 5(2):91-7. PMID: 15794910.
    Citations: 7     Fields:    Translation:Humans
  92. He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26. PMID: 15699040.
    Citations: 18     Fields:    Translation:AnimalsCells
  93. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8. PMID: 15689562.
    Citations: 23     Fields:    Translation:AnimalsCells
  94. Rask-Madsen C, King GL. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96. PMID: 15637306.
    Citations: 39     Fields:    Translation:HumansAnimals
  95. Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell SE, King GL, Johnstone MT, Horton ES, Veves A. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes. 2005 Jan; 54(1):204-11. PMID: 15616030.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  96. Scott JA, King GL. Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci. 2004 Dec; 1031:204-13. PMID: 15753146.
    Citations: 27     Fields:    Translation:HumansAnimals
  97. Treszl A, Szereday L, Doria A, King GL, Orban T. Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care. 2004 Nov; 27(11):2769-70. PMID: 15505025.
    Citations: 5     Fields:    Translation:Humans
  98. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol. 2004 Oct; 122(4):333-8. PMID: 15257460.
    Citations: 92     Fields:    Translation:HumansAnimals
  99. He Z, King GL. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 2004 Jul 06; 110(1):7-9. PMID: 15238466.
    Citations: 8     Fields:    Translation:Humans
  100. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74. PMID: 15128745.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  101. He Z, King GL. Microvascular complications of diabetes. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):215-38, xi-xii. PMID: 15053904.
    Citations: 25     Fields:    Translation:HumansAnimals
  102. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Retinopathy in diabetes. Diabetes Care. 2004 Jan; 27 Suppl 1:S84-7. PMID: 14693935.
    Citations: 158     Fields:    Translation:Humans
  103. Kuroki T, Isshiki K, King GL. Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol. 2003 Aug; 14(8 Suppl 3):S216-20. PMID: 12874434.
    Citations: 14     Fields:    Translation:HumansAnimals
  104. Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42. PMID: 12813019.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  105. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71. PMID: 12775712.
    Citations: 23     Fields:    Translation:AnimalsCells
  106. Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80. PMID: 12727929.
    Citations: 86     Fields:    Translation:AnimalsCells
  107. Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45. PMID: 12606528.
    Citations: 24     Fields:    Translation:AnimalsCells
  108. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37. PMID: 12606527.
    Citations: 35     Fields:    Translation:Animals
  109. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 2003 Jan; 26(1):226-9. PMID: 12502685.
    Citations: 60     Fields: