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Johnathan Whetstine, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM097360 (WHETSTINE, JOHNATHAN R.) Feb 1, 2012 - Dec 31, 2020
    Understanding chromatin modulation of copy number and rereplication
    Role: Principal Investigator
  2. F32GM070095 (WHETSTINE, JOHNATHAN R.) Feb 1, 2004 - Jan 31, 2007
    The Role of Chromatin Modification During Development
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 Nov 29; 175(6):1716. PMID: 30500540.
    Citations:    Fields:    
  2. Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 08 09; 174(4):803-817.e16. PMID: 30057114.
    Citations:    Fields:    
  3. Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017 12 18; 43(6):689-703.e5. PMID: 29233476.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017 04 15; 77(8):2018-2028. PMID: 28202526.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  5. Black JC, Zhang H, Kim J, Getz G, Whetstine JR. Regulation of Transient Site-specific Copy Gain by MicroRNA. J Biol Chem. 2016 Mar 04; 291(10):4862-71. PMID: 26755726.
    Citations: 4     Fields:    Translation:HumansCells
  6. Mishra S, Whetstine JR. Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive. Mol Cell Biol. 2016 Jan 11; 36(7):1050-63. PMID: 26755558.
    Citations: 7     Fields:    Translation:HumansAnimals
  7. Black JC, Whetstine JR. RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma. Cancer Discov. 2015 Dec; 5(12):1241-3. PMID: 26637658.
    Citations: 1     Fields:    Translation:Humans
  8. Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov; 21(11):1290-7. PMID: 26501192.
    Citations: 36     Fields:    Translation:HumansAnimals
  9. Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S. SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes. Nat Commun. 2015 Sep 23; 6:8257. PMID: 26394836.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Black JC, Whetstine JR. Too little O2 Too much gain. Cell Cycle. 2015; 14(18):2869-70. PMID: 26221746.
    Citations: 2     Fields:    Translation:HumansAnimals
  11. Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15; 29(10):1018-31. PMID: 25995187.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  12. Van Rechem C, Black JC, Greninger P, Zhao Y, Donado C, Burrowes PD, Ladd B, Christiani DC, Benes CH, Whetstine JR. A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors. Cancer Discov. 2015 Mar; 5(3):245-54. PMID: 25564517.
    Citations: 8     Fields:    Translation:HumansCells
  13. Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gräslund S, Haas W, Benes CH, Whetstine JR. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar; 5(3):255-63. PMID: 25564516.
    Citations: 15     Fields:    Translation:HumansCells
  14. Whetstine JR. Methylation: a multifaceted modification - looking at transcription and beyond. Biochim Biophys Acta. 2014 Dec; 1839(12):1351-2. PMID: 25225044.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Van Rechem C, Whetstine JR. Examining the impact of gene variants on histone lysine methylation. Biochim Biophys Acta. 2014 Dec; 1839(12):1463-76. PMID: 24859469.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Rep. 2013 Dec 26; 5(6):1679-89. PMID: 24360956.
    Citations: 23     Fields:    Translation:HumansCells
  17. Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci Transl Med. 2013 Nov 20; 5(212):212ra162. PMID: 24259050.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  18. Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 2013 Aug 01; 154(3):541-55. PMID: 23871696.
    Citations: 68     Fields:    Translation:HumansCells
  19. Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol. 2013 Mar; 8(3):279-86. PMID: 23399959.
    Citations: 13     Fields:    Translation:HumansCells
  20. Black JC, Whetstine JR. Tipping the lysine methylation balance in disease. Biopolymers. 2013 Feb; 99(2):127-35. PMID: 23175387.
    Citations: 10     Fields:    Translation:HumansCells
  21. Black JC, Van Rechem C, Whetstine JR. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell. 2012 Nov 30; 48(4):491-507. PMID: 23200123.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  22. Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ. RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol. 2012 Nov; 32(21):4375-87. PMID: 22927638.
    Citations: 26     Fields:    Translation:AnimalsCells
  23. Black JC, Whetstine JR. LOX out, histones: a new enzyme is nipping at your tails. Mol Cell. 2012 May 11; 46(3):243-4. PMID: 22578539.
    Citations: 4     Fields:    
  24. Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem. 2011 Sep 02; 286(35):30462-70. PMID: 21757720.
    Citations: 29     Fields:    Translation:HumansCells
  25. Black JC, Whetstine JR. Chromatin landscape: methylation beyond transcription. Epigenetics. 2011 Jan; 6(1):9-15. PMID: 20855937.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  26. Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR. Conserved antagonism between JMJD2A/KDM4A and HP1? during cell cycle progression. Mol Cell. 2010 Dec 10; 40(5):736-48. PMID: 21145482.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  27. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  28. Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009 Nov; 11(11):1376-82. PMID: 19783983.
    Citations: 156     Fields:    Translation:HumansCells
  29. Chen S, Whetstine JR, Ghosh S, Hanover JA, Gali RR, Grosu P, Shi Y. The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1496-501. PMID: 19164523.
    Citations: 21     Fields:    Translation:AnimalsCells
  30. Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11; 449(7163):689-94. PMID: 17851529.
    Citations: 252     Fields:    Translation:HumansAnimalsCells
  31. Chen Z, Zang J, Kappler J, Hong X, Crawford F, Wang Q, Lan F, Jiang C, Whetstine J, Dai S, Hansen K, Shi Y, Zhang G. Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10818-23. PMID: 17567753.
    Citations: 49     Fields:    Translation:Cells
  32. Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23; 128(6):1077-88. PMID: 17320160.
    Citations: 243     Fields:    Translation:HumansAnimalsCells
  33. Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell. 2007 Jan 12; 25(1):1-14. PMID: 17218267.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  34. Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19; 125(4):691-702. PMID: 16677698.
    Citations: 126     Fields:    Translation:Cells
  35. Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 05; 125(3):467-81. PMID: 16603238.
    Citations: 332     Fields:    Translation:HumansAnimalsCells
  36. Whetstine JR, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Mol Cell. 2005 May 13; 18(4):483-90. PMID: 15893731.
    Citations: 27     Fields:    Translation:AnimalsCells
  37. Payton SG, Whetstine JR, Ge Y, Matherly LH. Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor. Biochim Biophys Acta. 2005 Jan 21; 1727(1):45-57. PMID: 15652157.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  38. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004 Dec 29; 119(7):941-53. PMID: 15620353.
    Citations: 1055     Fields:    Translation:HumansCells
  39. Liu M, Whetstine JR, Payton SG, Ge Y, Flatley RM, Matherly LH. Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. Biochem J. 2004 Oct 15; 383(Pt 2):249-57. PMID: 15214842.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  40. Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature. 2003 Apr 17; 422(6933):735-8. PMID: 12700765.
    Citations: 267     Fields:    Translation:HumansCells
  41. Gifford AJ, Haber M, Witt TL, Whetstine JR, Taub JW, Matherly LH, Norris MD. Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia. 2002 Dec; 16(12):2379-87. PMID: 12454742.
    Citations: 5     Fields:    Translation:HumansCells
  42. Whetstine JR, Flatley RM, Matherly LH. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem J. 2002 Nov 01; 367(Pt 3):629-40. PMID: 12144527.
    Citations: 31     Fields:    Translation:HumansCells
  43. Whetstine JR, Witt TL, Matherly LH. The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. J Biol Chem. 2002 Nov 15; 277(46):43873-80. PMID: 12228234.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  44. Whetstine JR, Gifford AJ, Witt T, Liu XY, Flatley RM, Norris M, Haber M, Taub JW, Ravindranath Y, Matherly LH. Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. Clin Cancer Res. 2001 Nov; 7(11):3416-22. PMID: 11705857.
    Citations: 16     Fields:    Translation:HumansCells
  45. Ding BC, Whetstine JR, Witt TL, Schuetz JD, Matherly LH. Repression of human reduced folate carrier gene expression by wild type p53. J Biol Chem. 2001 Mar 23; 276(12):8713-9. PMID: 11106643.
    Citations: 6     Fields:    Translation:HumansCells
  46. Whetstine JR, Matherly LH. The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression. J Biol Chem. 2001 Mar 02; 276(9):6350-8. PMID: 11078737.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  47. Whetstine JR, Yueh MF, McCarver DG, Williams DE, Park CS, Kang JH, Cha YN, Dolphin CT, Shephard EA, Phillips IR, Hines RN. Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. Toxicol Appl Pharmacol. 2000 Nov 01; 168(3):216-24. PMID: 11042094.
    Citations: 18     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.