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profileVasileios Kyttaris, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Rheumatology CLS 936
330 Brookline Ave
Boston MA 02215
Phone617/735-4162
Fax617/735-4170
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Available: 07/13/17, Expires: 06/01/18

We have preliminary data showing that conditionally knocking our STAT3 in CD4+ T cells decreases the production of autoantibodies in lupus prone mice. The project is a 2 year project whereas the student will be involved in determining how STAT3 inhibition (pharmacologic and genetic) affects the development of murine lupus and GBM nephritis.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AR060849     (KYTTARIS, VASILEIOS CHRISTOS)May 14, 2012 - Apr 30, 2017
NIH/NIAMS
The Role of Interleukin 23 in Lupus
Role: Principal Investigator

K23AR055672     (KYTTARIS, VASILEIOS CHRISTOS)Sep 11, 2008 - Aug 31, 2013
NIH/NIAMS
NFAT/AP-1 cooperation in SLE T cells
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Karampetsou MP, Comte D, Kis-Toth K, Kyttaris VC, Tsokos GC. Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus. PLoS One. 2017; 12(10):e0186073. PMID: 29020082.
    View in: PubMed
  2. Dai H, He F, Tsokos GC, Kyttaris VC. IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus. J Immunol. 2017 Aug 01; 199(3):903-910. PMID: 28646040.
    View in: PubMed
  3. Comte D, Karampetsou MP, Yoshida N, Kis-Toth K, Kyttaris VC, Tsokos GC. Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 May; 69(5):1035-1044. PMID: 28076903.
    View in: PubMed
  4. Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Kyttaris VC, Tsokos GC. Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2. Arthritis Rheumatol. 2017 Apr; 69(4):808-813. PMID: 27992687.
    View in: PubMed
  5. Kyttaris VC. Novel Treatments in Lupus. Curr Rheumatol Rep. 2017 Mar; 19(3):10. PMID: 28265845.
    View in: PubMed
  6. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 Apr 01; 198(7):2568-2577. PMID: 28219888.
    View in: PubMed
  7. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 Mar 01; 198(5):1846-1854. PMID: 28093526.
    View in: PubMed
  8. Wei S, Yoshida N, Finn G, Kozono S, Nechama M, Kyttaris VC, Zhen Zhou X, Tsokos GC, Ping Lu K. Pin1-Targeted Therapy for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 Oct; 68(10):2503-13. PMID: 27159270.
    View in: PubMed
  9. Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 Sep 29; 7:12993. PMID: 27680869.
    View in: PubMed
  10. Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Mizui M, Kono M, Solomon JR, Kyttaris VC, Tsokos GC. Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33):9321-6. PMID: 27482100; PMCID: PMC4995972 [Available on 02/16/17].
  11. Wang J, Mizui M, Zeng LF, Bronson R, Finnell M, Terhorst C, Kyttaris VC, Tsokos GC, Zhang ZY, Kontaridis MI. Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest. 2016 Jun 01; 126(6):2077-92. PMID: 27183387; PMCID: PMC4887187.
  12. Karampetsou MP, Comte D, Kis-Toth K, Terhorst C, Kyttaris VC, Tsokos GC. Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production. J Immunol. 2016 Jun 15; 196(12):4915-24. PMID: 27183584; PMCID: PMC4893906 [Available on 06/15/17].
  13. Deng GM, Kyttaris VC, Tsokos GC. Targeting Syk in Autoimmune Rheumatic Diseases. Front Immunol. 2016; 7:78. PMID: 27014261; PMCID: PMC4779881.
  14. Kis-Toth K, Comte D, Karampetsou MP, Kyttaris VC, Kannan L, Terhorst C, Tsokos GC. Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 Jan; 68(1):164-73. PMID: 26314831; PMCID: PMC4690788 [Available on 01/01/17].
  15. Bradley SJ, Suarez-Fueyo A, Moss DR, Kyttaris VC, Tsokos GC. T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus. PLoS One. 2015; 10(11):e0141171. PMID: 26544975; PMCID: PMC4636226.
  16. Edwards LJ, Mizui M, Kyttaris V. Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice. Clin Immunol. 2015 Jun; 158(2):221-30. PMID: 25869298; PMCID: PMC4465043.
  17. Schramm EC, Staten NR, Zhang Z, Bruce SS, Kellner C, Atkinson JP, Kyttaris VC, Tsokos GC, Petri M, Sander Connolly E, Olson PK. A quantitative lateral flow assay to detect complement activation in blood. Anal Biochem. 2015 May 15; 477:78-85. PMID: 25660530; PMCID: PMC4404182.
  18. Hedrich CM, Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C, Kyttaris VC, Crispin JC, Tsokos GC. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13457-62. PMID: 25187566; PMCID: PMC4169908.
  19. Grammatikos AP, Kyttaris VC, Kis-Toth K, Fitzgerald LM, Devlin A, Finnell MD, Tsokos GC. A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus. Clin Immunol. 2014 Feb; 150(2):192-200. PMID: 24434273; PMCID: PMC3932542.
  20. Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC. cAMP responsive element modulator (CREM) a mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem. 2014 Jan 24; 289(4):2361-70. PMID: 24297179; PMCID: PMC3900979.
  21. Bernstein HG, Kirches E, Bogerts B, Lendeckel U, Keilhoff G, Zempeltzi M, Steiner J, Tenbrock K, Dobrowolny H, Kyttaris VC, Mawrin C. Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains. Amino Acids. 2013 Dec; 45(6):1373-83. PMID: 24100545.
    View in: PubMed
  22. Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J Biol Chem. 2013 Nov 01; 288(44):31880-7. PMID: 24047902; PMCID: PMC3814780.
  23. Grammatikos AP, Ghosh D, Devlin A, Kyttaris VC, Tsokos GC. Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling. PLoS One. 2013; 8(8):e74550. PMID: 24013589; PMCID: PMC3754955.
  24. Kyttaris VC. Treatment of SLE: Current paradigm and future directions. Clin Immunol. 2013 Sep; 148(3):301-2. PMID: 23890714.
    View in: PubMed
  25. Kyttaris VC, Kampagianni O, Tsokos GC. Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice. Biomed Res Int. 2013; 2013:861028. PMID: 23841097; PMCID: PMC3690216.
  26. del Rio R, McAllister RD, Meeker ND, Wall EH, Bond JP, Kyttaris VC, Tsokos GC, Tung KS, Teuscher C. Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C. PLoS Genet. 2012; 8(12):e1003140. PMID: 23300462; PMCID: PMC3531464.
  27. Rauen T, Grammatikos AP, Hedrich CM, Floege J, Tenbrock K, Ohl K, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE). J Biol Chem. 2012 Dec 14; 287(51):42525-32. PMID: 23124208; PMCID: PMC3522254.
  28. Markopoulou A, Kyttaris VC. Small molecules in the treatment of systemic lupus erythematosus. Clin Immunol. 2013 Sep; 148(3):359-68. PMID: 23158694; PMCID: PMC3587286.
  29. Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC. cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16606-11. PMID: 23019580; PMCID: PMC3478624.
  30. Kyttaris VC. Kinase inhibitors: a new class of antirheumatic drugs. Drug Des Devel Ther. 2012; 6:245-50. PMID: 23055694; PMCID: PMC3457674.
  31. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 Oct 01; 189(7):3714-23. PMID: 22933624; PMCID: PMC3462585.
  32. Kyttaris VC. The role of Syk in osteoarthritis. Clin Immunol. 2012 Sep; 144(3):283-4. PMID: 22885814; PMCID: PMC3477518.
  33. Ghosh D, Tsokos GC, Kyttaris VC. c-Jun and Ets2 proteins regulate expression of spleen tyrosine kinase in T cells. J Biol Chem. 2012 Apr 06; 287(15):11833-41. PMID: 22354960; PMCID: PMC3320931.
  34. Kyttaris VC. Targeting B cells in severe thrombotic thrombocytopenic purpura--a road to cure? Crit Care Med. 2012 Jan; 40(1):317-8. PMID: 22179358; PMCID: PMC3243898.
  35. Chatterjee M, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol. 2012 Feb 01; 188(3):1206-12. PMID: 22184727; PMCID: PMC3262878.
  36. Hedrich CM, Rauen T, Kis-Toth K, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J Biol Chem. 2012 Feb 10; 287(7):4715-25. PMID: 22184122; PMCID: PMC3281648.
  37. Mitsiades N, Pazaitou-Panayiotou K, Aronis KN, Moon HS, Chamberland JP, Liu X, Diakopoulos KN, Kyttaris V, Panagiotou V, Mylvaganam G, Tseleni-Balafouta S, Mantzoros CS. Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies. J Clin Endocrinol Metab. 2011 Dec; 96(12):E2023-8. PMID: 21937620; PMCID: PMC3232611.
  38. Kyttaris VC, Tsokos GC. Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus. Curr Opin Rheumatol. 2011 Sep; 23(5):449-53. PMID: 21720246; PMCID: PMC3158574.
  39. Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K. A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus. J Biol Chem. 2011 Sep 16; 286(37):32366-72. PMID: 21757709; PMCID: PMC3173235.
  40. Kyttaris VC, Zhang Z, Kampagianni O, Tsokos GC. Calcium signaling in systemic lupus erythematosus T cells: a treatment target. Arthritis Rheum. 2011 Jul; 63(7):2058-66. PMID: 21437870; PMCID: PMC3128171.
  41. Sunahori K, Juang YT, Kyttaris VC, Tsokos GC. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol. 2011 Apr 01; 186(7):4508-17. PMID: 21346232; PMCID: PMC3148941.
  42. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12. PMID: 21280005; PMCID: PMC3334350.
  43. Juang YT, Peoples C, Kafri R, Kyttaris VC, Sunahori K, Kis-Toth K, Fitzgerald L, Ergin S, Finnell M, Tsokos GC. A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report. Lupus. 2011 Mar; 20(3):243-9. PMID: 21138984; PMCID: PMC3880791.
  44. Peponis V, Chalkiadakis S, Ergin S, Kyttaris VC. Chemosis as a presenting symptom of systemic lupus erythematosus. Lupus. 2010 Jul; 19(8):997-1001. PMID: 20581021; PMCID: PMC3872738.
  45. Deng GM, Liu L, Kyttaris VC, Tsokos GC. Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway. J Immunol. 2010 Jun 15; 184(12):7154-61. PMID: 20483718; PMCID: PMC2926650.
  46. Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol. 2010 Jun; 6(6):317-25. PMID: 20458333; PMCID: PMC2924434.
  47. Crispín JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity. Arthritis Rheum. 2010 May; 62(5):1431-7. PMID: 20213807; PMCID: PMC2879041.
  48. Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol. 2010 May 01; 184(9):4605-9. PMID: 20308633; PMCID: PMC2926666.
  49. Peponis V, Kyttaris VC, Chalkiadakis SE, Bonovas S, Sitaras NM. Ocular side effects of anti-rheumatic medications: what a rheumatologist should know. Lupus. 2010 May; 19(6):675-82. PMID: 20144965; PMCID: PMC2926651.
  50. Crispín JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med. 2010 Feb; 16(2):47-57. PMID: 20138006; PMCID: PMC2823952.
  51. Kyttaris VC. Systemic lupus erythematosus: from genes to organ damage. Methods Mol Biol. 2010; 662:265-83. PMID: 20824476; PMCID: PMC3153363.
  52. Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol. 2009 Sep 01; 183(5):3160-9. PMID: 19657089; PMCID: PMC2766304.
  53. Kriegel MA, Van Beek C, Mostaghimi A, Kyttaris VC. Sterile empyematous pleural effusion in a patient with systemic lupus erythematosus: a diagnostic challenge. Lupus. 2009 Jun; 18(7):581-5. PMID: 19433457; PMCID: PMC2730512.
  54. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 Dec 15; 181(12):8761-6. PMID: 19050297; PMCID: PMC2596652.
  55. Krishnan S, Juang YT, Chowdhury B, Magilavy A, Fisher CU, Nguyen H, Nambiar MP, Kyttaris V, Weinstein A, Bahjat R, Pine P, Rus V, Tsokos GC. Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells. J Immunol. 2008 Dec 01; 181(11):8145-52. PMID: 19018007; PMCID: PMC2586973.
  56. Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC. PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells. J Immunol. 2008 Sep 01; 181(5):3658-64. PMID: 18714041; PMCID: PMC2662392.
  57. Cohen RA, Bayliss G, Crispin JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol. 2008 Jul; 128(1):1-7. PMID: 18565470; PMCID: PMC2497421.
  58. Kyttaris VC, Costenbader KH. Whole genome association study results shed light on elusive aetiopathogenesis of systemic lupus erythematosus. Int J Clin Pract. 2008 Jun; 62(6):852-4. PMID: 18479278; PMCID: PMC2711002.
  59. Moulton VR, Kyttaris VC, Juang YT, Chowdhury B, Tsokos GC. The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex. J Biol Chem. 2008 Jul 18; 283(29):20037-44. PMID: 18505733; PMCID: PMC2459291.
  60. Crispín JC, Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol. 2008 Mar; 29(3):110-5. PMID: 18249583.
    View in: PubMed
  61. Crispín JC, Kyttaris V, Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann Rheum Dis. 2007 Nov; 66 Suppl 3:iii65-9. PMID: 17934100; PMCID: PMC2095294.
  62. Juang YT, Sumibcay L, Tolnay M, Wang Y, Kyttaris VC, Tsokos GC. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. J Immunol. 2007 Oct 01; 179(7):4884-9. PMID: 17878388.
    View in: PubMed
  63. Kyttaris VC, Tsokos GC. Syk kinase as a treatment target for therapy in autoimmune diseases. Clin Immunol. 2007 Sep; 124(3):235-7. PMID: 17662659; PMCID: PMC1986716.
  64. Tenbrock K, Juang YT, Kyttaris VC, Tsokos GC. Altered signal transduction in SLE T cells. Rheumatology (Oxford). 2007 Oct; 46(10):1525-30. PMID: 17586862.
    View in: PubMed
  65. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J Immunol. 2007 Feb 01; 178(3):1960-6. PMID: 17237447.
    View in: PubMed
  66. Kyttaris VC, Timbil S, Kalliabakos D, Vaiopoulos G, Weinstein A. Calciphylaxis: a pseudo-vasculitis syndrome. Semin Arthritis Rheum. 2007 Feb; 36(4):264-7. PMID: 17276174.
    View in: PubMed
  67. Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, Tsokos GC. Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity. 2007 Feb; 40(1):1-8. PMID: 17364491.
    View in: PubMed
  68. Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, Tung K, Tsokos GC. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol. 2007 Feb 01; 178(3):1938-47. PMID: 17237445.
    View in: PubMed
  69. Kyttaris VC, Krishnan S, Tsokos GC. Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function. Autoimmunity. 2006 Dec; 39(8):705-9. PMID: 17178567.
    View in: PubMed
  70. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. CAMP response element modulator a expression in patients with systemic lupus erythematosus. Lupus. 2006; 15(12):840-4. PMID: 17211988.
    View in: PubMed
  71. Peponis V, Kyttaris VC, Tyradellis C, Vergados I, Sitaras NM. Ocular manifestations of systemic lupus erythematosus: a clinical review. Lupus. 2006; 15(1):3-12. PMID: 16482739.
    View in: PubMed
  72. Kyttaris VC, Sfikakis PP, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Curr Gene Ther. 2005 Dec; 5(6):677-84. PMID: 16457656.
    View in: PubMed
  73. Kyttaris VC, Katsiari CG, Juang YT, Tsokos GC. New insights into the pathogenesis of systemic lupus erythematosus. Curr Rheumatol Rep. 2005 Dec; 7(6):469-75. PMID: 16303108.
    View in: PubMed
  74. Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, Mawrin C, Roth J, Sorg C, Juang YT, Tsokos GC. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol. 2005 Nov 01; 175(9):5975-80. PMID: 16237091.
    View in: PubMed
  75. Katsiari CG, Kyttaris VC, Juang YT, Tsokos GC. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J Clin Invest. 2005 Nov; 115(11):3193-204. PMID: 16224536; PMCID: PMC1253625.
  76. Krishnan S, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, Chowdhury B, Rus V, Tsokos GC. Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells. J Immunol. 2005 Sep 01; 175(5):3417-23. PMID: 16116236.
    View in: PubMed
  77. Kyttaris VC, Juang YT, Tsokos GC. Immune cells and cytokines in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2005 Sep; 17(5):518-22. PMID: 16093827.
    View in: PubMed
  78. Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest. 2005 Apr; 115(4):996-1005. PMID: 15841182; PMCID: PMC1070410.
  79. Kyttaris VC, Tsokos GC. T lymphocytes in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2004 Sep; 16(5):548-52. PMID: 15314492.
    View in: PubMed
  80. Kyttaris VC, Juang YT, Tenbrock K, Weinstein A, Tsokos GC. Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol. 2004 Sep 01; 173(5):3557-63. PMID: 15322221.
    View in: PubMed
  81. Elliott MR, Shanks RA, Khan IU, Brooks JW, Burkett PJ, Nelson BJ, Kyttaris V, Juang YT, Tsokos GC, Kammer GM. Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta. J Immunol. 2004 Jun 15; 172(12):7804-12. PMID: 15187164.
    View in: PubMed
  82. Kyttaris VC, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Lupus. 2004; 13(5):353-8. PMID: 15230292.
    View in: PubMed
  83. Kyttaris V, Tsokos G. Uncovering the genetics of systemic lupus erythematosus: implications for therapy. Am J Pharmacogenomics. 2003; 3(3):193-202. PMID: 12814327.
    View in: PubMed
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