Harvard Catalyst Profiles

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Vasileios Kyttaris, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR060849 (KYTTARIS, VASILEIOS CHRISTOS) May 14, 2012 - Aug 31, 2017
    The Role of Interleukin 23 in Lupus
    Role: Principal Investigator
  2. K23AR055672 (KYTTARIS, VASILEIOS CHRISTOS) Sep 11, 2008 - Aug 31, 2013
    NFAT/AP-1 cooperation in SLE T cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Good SD, Wade SD, Kyttaris VC. The spectrum of hemophagocytic lymphohistiocytosis: a retrospective study comparing adult macrophage activation syndrome to malignancy-associated hemophagocytic lymphohistiocytosis. Rheumatol Int. 2022 Jan 11. PMID: 35015099.
    Citations:    Fields:    
  2. Magliulo D, Wade SD, Kyttaris VC. Immunogenicity of SARS-CoV-2 vaccination in rituximab-treated patients: Effect of timing and immunologic parameters. Clin Immunol. 2022 01; 234:108897. PMID: 34848357.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  3. Ramanujan SA, Cravens EN, Krishfield SM, Kyttaris VC, Moulton VR. Estrogen-Induced hsa-miR-10b-5p Is Elevated in T Cells From Patients With Systemic Lupus Erythematosus and Down-Regulates Serine/Arginine-Rich Splicing Factor 1. Arthritis Rheumatol. 2021 11; 73(11):2052-2058. PMID: 33982889.
    Citations: 2     Fields:    Translation:HumansCells
  4. Wade SD, Freed JA, Kyttaris VC, Saunders S, Hausmann JS. Implementing a Virtual Flipped Classroom in a Rheumatology Fellowship Program. Arthritis Care Res (Hoboken). 2021 Sep 22. PMID: 34553499.
    Citations:    Fields:    
  5. Rubio J, Kyttaris V. Journal Club: Efficacy and Safety of Voclosporin Versus Placebo for Lupus Nephritis (AURORA 1): A Double-Blind, Randomized, Multicenter, Placebo-Controlled, Phase 3 Trial. ACR Open Rheumatol. 2021 Dec; 3(12):827-831. PMID: 34463434.
  6. Umeda M, Yoshida N, Hisada R, Burbano C, Orite SYK, Kono M, Kyttaris VC, Krishfield S, Owen CA, Tsokos GC. ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-ß1. Proc Natl Acad Sci U S A. 2021 05 04; 118(18). PMID: 33911034.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Rubio J, Kyttaris VC. Measuring IFN activity in suspected SLE: a valuable step? Expert Rev Clin Immunol. 2021 06; 17(6):545-548. PMID: 33827358.
    Citations:    Fields:    Translation:Humans
  8. Wade SD, Kyttaris VC. Rituximab-associated hypogammaglobulinemia in autoimmune rheumatic diseases: a single-center retrospective cohort study. Rheumatol Int. 2021 Jun; 41(6):1115-1124. PMID: 33811499.
    Citations: 2     Fields:    Translation:Humans
  9. Katsuyama T, Li H, Krishfield SM, Kyttaris VC, Moulton VR. Splicing factor SRSF1 limits IFN-? production via RhoH and ameliorates experimental nephritis. Rheumatology (Oxford). 2021 01 05; 60(1):420-429. PMID: 32810232.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Zaki MM, Virk ZM, Lopez D, Klubnick J, Ahrendsen JT, Varma H, Kyttaris V, Abeles I. A case of statin-associated immune-mediated necrotizing myopathy with atypical biopsy features. Eur J Rheumatol. 2021 Jan; 8(1):36-39. PMID: 33372889.
  11. Vukelic M, Laloo A, Kyttaris VC. Interleukin 23 is elevated in the serum of patients with SLE. Lupus. 2020 Dec; 29(14):1943-1947. PMID: 32838622.
    Citations: 2     Fields:    Translation:HumansAnimals
  12. Katsuyama T, Martin-Delgado IJ, Krishfield SM, Kyttaris VC, Moulton VR. Splicing factor SRSF1 controls T cell homeostasis and its decreased levels are linked to lymphopenia in systemic lupus erythematosus. Rheumatology (Oxford). 2020 08 01; 59(8):2146-2155. PMID: 32206811.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Serine/threonine phosphatase PP2A is essential for optimal B cell function. JCI Insight. 2020 03 12; 5(5). PMID: 32161189.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Rubio J, Krishfield S, Kyttaris VC. Application of the 2019 European League Against Rheumatism/American College of Rheumatology systemic lupus erythematosus classification criteria in clinical practice: a single center experience. Lupus. 2020 Apr; 29(4):421-425. PMID: 32098572.
    Citations: 2     Fields:    Translation:Humans
  15. Katsuyama E, Suarez-Fueyo A, Bradley SJ, Mizui M, Marin AV, Mulki L, Krishfield S, Malavasi F, Yoon J, Sui SJH, Kyttaris VC, Tsokos GC. The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections. Cell Rep. 2020 01 07; 30(1):112-123.e4. PMID: 31914379.
    Citations: 39     Fields:    Translation:HumansCells
  16. Kono M, Yoshida N, Maeda K, Suárez-Fueyo A, Kyttaris VC, Tsokos GC. Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis. Arthritis Rheumatol. 2019 11; 71(11):1869-1878. PMID: 31233276.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  17. Yoshida N, He F, Kyttaris VC. T cell-specific STAT3 deficiency abrogates lupus nephritis. Lupus. 2019 Oct; 28(12):1468-1472. PMID: 31551033.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Kyttaris VC. Targeting cytokines to treat autoimmunity. Clin Immunol. 2019 09; 206:108251. PMID: 31445171.
    Citations: 3     Fields:    Translation:Humans
  19. Dai H, Kyttaris VC. Interleukin-23 deficiency alters thymic selection in lupus-prone mice. Lupus. 2019 Jul; 28(8):1007-1012. PMID: 31166866.
    Citations:    Fields:    Translation:AnimalsCells
  20. Karampetsou MP, Comte D, Suárez-Fueyo A, Katsuyama E, Yoshida N, Kono M, Kyttaris VC, Tsokos GC. Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 01; 71(1):99-108. PMID: 30058241.
    Citations: 5     Fields:    Translation:HumansCells
  21. Vukelic M, Li Y, Kyttaris VC. Novel Treatments in Lupus. Front Immunol. 2018; 9:2658. PMID: 30524430.
    Citations: 12     Fields:    Translation:HumansCells
  22. Kono M, Yoshida N, Maeda K, Skinner NE, Pan W, Kyttaris VC, Tsokos MG, Tsokos GC. Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9288-9293. PMID: 30150402.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  23. Laloo A, Kyttaris VC. Polyarticular septic arthritis caused by Staphylococcus lugdunensis in a patient with systemic lupus erythematosus. Eur J Rheumatol. 2018 Dec; 5(4):266-268. PMID: 30071944.
  24. Suárez-Fueyo A, Bradley SJ, Katsuyama T, Solomon S, Katsuyama E, Kyttaris VC, Moulton VR, Tsokos GC. Downregulation of CD3? in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype. J Immunol. 2018 05 01; 200(9):3077-3086. PMID: 29602774.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Karampetsou MP, Comte D, Kis-Toth K, Kyttaris VC, Tsokos GC. Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus. PLoS One. 2017; 12(10):e0186073. PMID: 29020082.
    Citations: 11     Fields:    Translation:HumansCells
  26. Dai H, He F, Tsokos GC, Kyttaris VC. IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus. J Immunol. 2017 08 01; 199(3):903-910. PMID: 28646040.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  27. Comte D, Karampetsou MP, Yoshida N, Kis-Toth K, Kyttaris VC, Tsokos GC. Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 05; 69(5):1035-1044. PMID: 28076903.
    Citations: 21     Fields:    Translation:HumansCells
  28. Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Kyttaris VC, Tsokos GC. Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2. Arthritis Rheumatol. 2017 04; 69(4):808-813. PMID: 27992687.
    Citations: 15     Fields:    Translation:HumansCells
  29. Kyttaris VC. Novel Treatments in Lupus. Curr Rheumatol Rep. 2017 Mar; 19(3):10. PMID: 28265845.
    Citations: 2     Fields:    Translation:Humans
  30. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 04 01; 198(7):2568-2577. PMID: 28219888.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 03 01; 198(5):1846-1854. PMID: 28093526.
    Citations: 10     Fields:    Translation:AnimalsCells
  32. Wei S, Yoshida N, Finn G, Kozono S, Nechama M, Kyttaris VC, Zhen Zhou X, Tsokos GC, Ping Lu K. Pin1-Targeted Therapy for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 10; 68(10):2503-13. PMID: 27159270.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 Sep 29; 7:12993. PMID: 27680869.
    Citations: 22     Fields:    
  34. Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Mizui M, Kono M, Solomon JR, Kyttaris VC, Tsokos GC. Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):9321-6. PMID: 27482100.
    Citations: 15     Fields:    Translation:HumansCells
  35. Wang J, Mizui M, Zeng LF, Bronson R, Finnell M, Terhorst C, Kyttaris VC, Tsokos GC, Zhang ZY, Kontaridis MI. Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest. 2016 06 01; 126(6):2077-92. PMID: 27183387.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  36. Karampetsou MP, Comte D, Kis-Toth K, Terhorst C, Kyttaris VC, Tsokos GC. Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production. J Immunol. 2016 06 15; 196(12):4915-24. PMID: 27183584.
    Citations: 6     Fields:    Translation:HumansCells
  37. Deng GM, Kyttaris VC, Tsokos GC. Targeting Syk in Autoimmune Rheumatic Diseases. Front Immunol. 2016; 7:78. PMID: 27014261.
    Citations: 23     Fields:    
  38. Kis-Toth K, Comte D, Karampetsou MP, Kyttaris VC, Kannan L, Terhorst C, Tsokos GC. Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 Jan; 68(1):164-73. PMID: 26314831.
    Citations: 26     Fields:    Translation:HumansCells
  39. Bradley SJ, Suarez-Fueyo A, Moss DR, Kyttaris VC, Tsokos GC. T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus. PLoS One. 2015; 10(11):e0141171. PMID: 26544975.
    Citations: 22     Fields:    Translation:HumansCells
  40. Edwards LJ, Mizui M, Kyttaris V. Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice. Clin Immunol. 2015 Jun; 158(2):221-30. PMID: 25869298.
    Citations: 27     Fields:    Translation:AnimalsCells
  41. Schramm EC, Staten NR, Zhang Z, Bruce SS, Kellner C, Atkinson JP, Kyttaris VC, Tsokos GC, Petri M, Sander Connolly E, Olson PK. A quantitative lateral flow assay to detect complement activation in blood. Anal Biochem. 2015 May 15; 477:78-85. PMID: 25660530.
    Citations: 16     Fields:    Translation:Humans
  42. Hedrich CM, Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C, Kyttaris VC, Crispin JC, Tsokos GC. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13457-62. PMID: 25187566.
    Citations: 60     Fields:    Translation:HumansCells
  43. Grammatikos AP, Kyttaris VC, Kis-Toth K, Fitzgerald LM, Devlin A, Finnell MD, Tsokos GC. A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus. Clin Immunol. 2014 Feb; 150(2):192-200. PMID: 24434273.
    Citations: 18     Fields:    Translation:HumansCells
  44. Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC. cAMP responsive element modulator (CREM) a mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem. 2014 Jan 24; 289(4):2361-70. PMID: 24297179.
    Citations: 29     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  45. Bernstein HG, Kirches E, Bogerts B, Lendeckel U, Keilhoff G, Zempeltzi M, Steiner J, Tenbrock K, Dobrowolny H, Kyttaris VC, Mawrin C. Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains. Amino Acids. 2013 Dec; 45(6):1373-83. PMID: 24100545.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  46. Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J Biol Chem. 2013 Nov 01; 288(44):31880-7. PMID: 24047902.
    Citations: 23     Fields:    Translation:HumansCellsCTClinical Trials
  47. Grammatikos AP, Ghosh D, Devlin A, Kyttaris VC, Tsokos GC. Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling. PLoS One. 2013; 8(8):e74550. PMID: 24013589.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  48. Kyttaris VC. Treatment of SLE: Current paradigm and future directions. Clin Immunol. 2013 Sep; 148(3):301-2. PMID: 23890714.
  49. Kyttaris VC, Kampagianni O, Tsokos GC. Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone mice. Biomed Res Int. 2013; 2013:861028. PMID: 23841097.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  50. del Rio R, McAllister RD, Meeker ND, Wall EH, Bond JP, Kyttaris VC, Tsokos GC, Tung KS, Teuscher C. Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C. PLoS Genet. 2012; 8(12):e1003140. PMID: 23300462.
    Citations: 3     Fields:    Translation:HumansAnimals
  51. Rauen T, Grammatikos AP, Hedrich CM, Floege J, Tenbrock K, Ohl K, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE). J Biol Chem. 2012 Dec 14; 287(51):42525-32. PMID: 23124208.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  52. Markopoulou A, Kyttaris VC. Small molecules in the treatment of systemic lupus erythematosus. Clin Immunol. 2013 Sep; 148(3):359-68. PMID: 23158694.
    Citations: 10     Fields:    Translation:HumansAnimals
  53. Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC. cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16606-11. PMID: 23019580.
    Citations: 43     Fields:    Translation:HumansCells
  54. Kyttaris VC. Kinase inhibitors: a new class of antirheumatic drugs. Drug Des Devel Ther. 2012; 6:245-50. PMID: 23055694.
    Citations: 26     Fields:    Translation:Humans
  55. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 Oct 01; 189(7):3714-23. PMID: 22933624.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  56. Kyttaris VC. The role of Syk in osteoarthritis. Clin Immunol. 2012 Sep; 144(3):283-4. PMID: 22885814.
    Citations: 1     Fields:    Translation:HumansAnimals
  57. Ghosh D, Tsokos GC, Kyttaris VC. c-Jun and Ets2 proteins regulate expression of spleen tyrosine kinase in T cells. J Biol Chem. 2012 Apr 06; 287(15):11833-41. PMID: 22354960.
    Citations: 6     Fields:    Translation:HumansCells
  58. Kyttaris VC. Targeting B cells in severe thrombotic thrombocytopenic purpura--a road to cure? Crit Care Med. 2012 Jan; 40(1):317-8. PMID: 22179358.
    Citations: 1     Fields:    Translation:Humans
  59. Chatterjee M, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC. Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. J Immunol. 2012 Feb 01; 188(3):1206-12. PMID: 22184727.
    Citations: 33     Fields:    Translation:HumansCells
  60. Hedrich CM, Rauen T, Kis-Toth K, Kyttaris VC, Tsokos GC. cAMP-responsive element modulator a (CREMa) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J Biol Chem. 2012 Feb 10; 287(7):4715-25. PMID: 22184122.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  61. Mitsiades N, Pazaitou-Panayiotou K, Aronis KN, Moon HS, Chamberland JP, Liu X, Diakopoulos KN, Kyttaris V, Panagiotou V, Mylvaganam G, Tseleni-Balafouta S, Mantzoros CS. Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies. J Clin Endocrinol Metab. 2011 Dec; 96(12):E2023-8. PMID: 21937620.
    Citations: 24     Fields:    Translation:Humans
  62. Kyttaris VC, Tsokos GC. Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus. Curr Opin Rheumatol. 2011 Sep; 23(5):449-53. PMID: 21720246.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  63. Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K. A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus. J Biol Chem. 2011 Sep 16; 286(37):32366-72. PMID: 21757709.
    Citations: 11     Fields:    Translation:HumansCells
  64. Kyttaris VC, Zhang Z, Kampagianni O, Tsokos GC. Calcium signaling in systemic lupus erythematosus T cells: a treatment target. Arthritis Rheum. 2011 Jul; 63(7):2058-66. PMID: 21437870.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  65. Sunahori K, Juang YT, Kyttaris VC, Tsokos GC. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol. 2011 Apr 01; 186(7):4508-17. PMID: 21346232.
    Citations: 28     Fields:    Translation:HumansCells
  66. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12. PMID: 21280005.
    Citations: 15     Fields:    Translation:HumansCells
  67. Juang YT, Peoples C, Kafri R, Kyttaris VC, Sunahori K, Kis-Toth K, Fitzgerald L, Ergin S, Finnell M, Tsokos GC. A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report. Lupus. 2011 Mar; 20(3):243-9. PMID: 21138984.
    Citations: 8     Fields:    Translation:Humans
  68. Peponis V, Chalkiadakis S, Ergin S, Kyttaris VC. Chemosis as a presenting symptom of systemic lupus erythematosus. Lupus. 2010 Jul; 19(8):997-1001. PMID: 20581021.
    Citations: 2     Fields:    Translation:Humans
  69. Deng GM, Liu L, Kyttaris VC, Tsokos GC. Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway. J Immunol. 2010 Jun 15; 184(12):7154-61. PMID: 20483718.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  70. Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol. 2010 Jun; 6(6):317-25. PMID: 20458333.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  71. Crispín JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity. Arthritis Rheum. 2010 May; 62(5):1431-7. PMID: 20213807.
    Citations: 31     Fields:    Translation:HumansCells
  72. Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol. 2010 May 01; 184(9):4605-9. PMID: 20308633.
    Citations: 81     Fields:    Translation:AnimalsCells
  73. Peponis V, Kyttaris VC, Chalkiadakis SE, Bonovas S, Sitaras NM. Ocular side effects of anti-rheumatic medications: what a rheumatologist should know. Lupus. 2010 May; 19(6):675-82. PMID: 20144965.
    Citations: 11     Fields:    Translation:Humans
  74. Crispín JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med. 2010 Feb; 16(2):47-57. PMID: 20138006.
    Citations: 128     Fields:    Translation:HumansAnimals
  75. Kyttaris VC. Systemic lupus erythematosus: from genes to organ damage. Methods Mol Biol. 2010; 662:265-83. PMID: 20824476.
    Citations: 11     Fields:    Translation:Humans
  76. Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol. 2009 Sep 01; 183(5):3160-9. PMID: 19657089.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  77. Kriegel MA, Van Beek C, Mostaghimi A, Kyttaris VC. Sterile empyematous pleural effusion in a patient with systemic lupus erythematosus: a diagnostic challenge. Lupus. 2009 Jun; 18(7):581-5. PMID: 19433457.
    Citations: 3     Fields:    Translation:Humans
  78. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 Dec 15; 181(12):8761-6. PMID: 19050297.
    Citations: 303     Fields:    Translation:HumansCells
  79. Krishnan S, Juang YT, Chowdhury B, Magilavy A, Fisher CU, Nguyen H, Nambiar MP, Kyttaris V, Weinstein A, Bahjat R, Pine P, Rus V, Tsokos GC. Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells. J Immunol. 2008 Dec 01; 181(11):8145-52. PMID: 19018007.
    Citations: 52     Fields:    Translation:HumansCells
  80. Juang YT, Wang Y, Jiang G, Peng HB, Ergin S, Finnell M, Magilavy A, Kyttaris VC, Tsokos GC. PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells. J Immunol. 2008 Sep 01; 181(5):3658-64. PMID: 18714041.
    Citations: 29     Fields:    Translation:HumansCells
  81. Cohen RA, Bayliss G, Crispin JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol. 2008 Jul; 128(1):1-7. PMID: 18565470.
    Citations: 16     Fields:    Translation:HumansCells
  82. Kyttaris VC, Costenbader KH. Whole genome association study results shed light on elusive aetiopathogenesis of systemic lupus erythematosus. Int J Clin Pract. 2008 Jun; 62(6):852-4. PMID: 18479278.
    Citations:    Fields:    Translation:Humans
  83. Moulton VR, Kyttaris VC, Juang YT, Chowdhury B, Tsokos GC. The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex. J Biol Chem. 2008 Jul 18; 283(29):20037-44. PMID: 18505733.
    Citations: 19     Fields:    Translation:HumansCells
  84. Crispín JC, Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol. 2008 Mar; 29(3):110-5. PMID: 18249583.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  85. Crispín JC, Kyttaris V, Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann Rheum Dis. 2007 Nov; 66 Suppl 3:iii65-9. PMID: 17934100.
    Citations: 7     Fields:    Translation:HumansCells
  86. Juang YT, Sumibcay L, Tolnay M, Wang Y, Kyttaris VC, Tsokos GC. Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression. J Immunol. 2007 Oct 01; 179(7):4884-9. PMID: 17878388.
    Citations: 7     Fields:    Translation:HumansCells
  87. Kyttaris VC, Tsokos GC. Syk kinase as a treatment target for therapy in autoimmune diseases. Clin Immunol. 2007 Sep; 124(3):235-7. PMID: 17662659.
    Citations: 13     Fields:    Translation:HumansCells
  88. Tenbrock K, Juang YT, Kyttaris VC, Tsokos GC. Altered signal transduction in SLE T cells. Rheumatology (Oxford). 2007 Oct; 46(10):1525-30. PMID: 17586862.
    Citations: 23     Fields:    Translation:HumansCells
  89. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J Immunol. 2007 Feb 01; 178(3):1960-6. PMID: 17237447.
    Citations: 34     Fields:    Translation:HumansCells
  90. Kyttaris VC, Timbil S, Kalliabakos D, Vaiopoulos G, Weinstein A. Calciphylaxis: a pseudo-vasculitis syndrome. Semin Arthritis Rheum. 2007 Feb; 36(4):264-7. PMID: 17276174.
    Citations: 3     Fields:    Translation:Humans
  91. Harada T, Kyttaris V, Li Y, Juang YT, Wang Y, Tsokos GC. Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity. 2007 Feb; 40(1):1-8. PMID: 17364491.
    Citations: 38     Fields:    Translation:HumansCells
  92. Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, Tung K, Tsokos GC. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol. 2007 Feb 01; 178(3):1938-47. PMID: 17237445.
    Citations: 81     Fields:    Translation:HumansCells
  93. Kyttaris VC, Krishnan S, Tsokos GC. Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function. Autoimmunity. 2006 Dec; 39(8):705-9. PMID: 17178567.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  94. Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC. CAMP response element modulator a expression in patients with systemic lupus erythematosus. Lupus. 2006; 15(12):840-4. PMID: 17211988.
    Citations: 14     Fields:    Translation:HumansCells
  95. Peponis V, Kyttaris VC, Tyradellis C, Vergados I, Sitaras NM. Ocular manifestations of systemic lupus erythematosus: a clinical review. Lupus. 2006; 15(1):3-12. PMID: 16482739.
    Citations: 14     Fields:    Translation:Humans
  96. Kyttaris VC, Sfikakis PP, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Curr Gene Ther. 2005 Dec; 5(6):677-84. PMID: 16457656.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  97. Kyttaris VC, Katsiari CG, Juang YT, Tsokos GC. New insights into the pathogenesis of systemic lupus erythematosus. Curr Rheumatol Rep. 2005 Dec; 7(6):469-75. PMID: 16303108.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  98. Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, Mawrin C, Roth J, Sorg C, Juang YT, Tsokos GC. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol. 2005 Nov 01; 175(9):5975-80. PMID: 16237091.
    Citations: 20     Fields:    Translation:HumansCells
  99. Katsiari CG, Kyttaris VC, Juang YT, Tsokos GC. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J Clin Invest. 2005 Nov; 115(11):3193-204. PMID: 16224536.
    Citations: 67     Fields:    Translation:HumansCells
  100. Krishnan S, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, Chowdhury B, Rus V, Tsokos GC. Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells. J Immunol. 2005 Sep 01; 175(5):3417-23. PMID: 16116236.
    Citations: 26     Fields:    Translation:HumansCells
  101. Kyttaris VC, Juang YT, Tsokos GC. Immune cells and cytokines in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2005 Sep; 17(5):518-22. PMID: 16093827.
    Citations: 40     Fields:    Translation:HumansCells
  102. Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest. 2005 Apr; 115(4):996-1005. PMID: 15841182.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  103. Kyttaris VC, Tsokos GC. T lymphocytes in systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2004 Sep; 16(5):548-52. PMID: 15314492.
    Citations: 19     Fields:    Translation:HumansCells
  104. Kyttaris VC, Juang YT, Tenbrock K, Weinstein A, Tsokos GC. Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol. 2004 Sep 01; 173(5):3557-63. PMID: 15322221.
    Citations: 30     Fields:    Translation:HumansCells
  105. Elliott MR, Shanks RA, Khan IU, Brooks JW, Burkett PJ, Nelson BJ, Kyttaris V, Juang YT, Tsokos GC, Kammer GM. Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta. J Immunol. 2004 Jun 15; 172(12):7804-12. PMID: 15187164.
    Citations: 5     Fields:    Translation:HumansCells
  106. Kyttaris VC, Juang YT, Tsokos GC. Gene therapy in systemic lupus erythematosus. Lupus. 2004; 13(5):353-8. PMID: 15230292.
    Citations:    Fields:    Translation:Humans
  107. Kyttaris V, Tsokos G. Uncovering the genetics of systemic lupus erythematosus: implications for therapy. Am J Pharmacogenomics. 2003; 3(3):193-202. PMID: 12814327.
    Citations: 3     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.