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Danwei Huangfu, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Beer MA, Shigaki D, Huangfu D. Enhancer Predictions and Genome-Wide Regulatory Circuits. Annu Rev Genomics Hum Genet. 2020 May 22. PMID: 32443951.
    Citations:    
  2. Li QV, Rosen BP, Huangfu D. Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency. Wiley Interdiscip Rev Syst Biol Med. 2020 Jan; 12(1):e1464. PMID: 31407519.
    Citations:    
  3. Lee K, Cho H, Rickert RW, Li QV, Pulecio J, Leslie CS, Huangfu D. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep. 2019 07 09; 28(2):382-393.e7. PMID: 31291575.
    Citations:    
  4. Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Carmona Fontaine C, Thompson CB, Finley LWS. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019 07; 1(7):676-687. PMID: 31511848.
    Citations:    
  5. Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nat Genet. 2019 06; 51(6):999-1010. PMID: 31110351.
    Citations:    
  6. Teijeiro V, Yang D, Majumdar S, González F, Rickert RW, Xu C, Koche R, Verma N, Lai EC, Huangfu D. DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells. Stem Cell Reports. 2018 09 11; 11(3):616-625. PMID: 30146489.
    Citations:    Fields:    
  7. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. PMID: 29781950.
    Citations:    Fields:    
  8. Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, Huangfu D, Chen S. Discovery of a drug candidate for GLIS3-associated diabetes. Nat Commun. 2018 07 11; 9(1):2681. PMID: 29992946.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Shukla A, Huangfu D. Decoding the noncoding genome via large-scale CRISPR screens. Curr Opin Genet Dev. 2018 10; 52:70-76. PMID: 29913329.
    Citations:    Fields:    
  10. Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet. 2018 05; 50(5):764. PMID: 29255265.
    Citations:    Fields:    
  11. Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. Publisher Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet. 2018 05; 50(5):764. PMID: 29255266.
    Citations:    Fields:    
  12. Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet. 2018 01; 50(1):83-95. PMID: 29203910.
    Citations: 3     Fields:    
  13. Pulecio J, Verma N, Mejía-Ramírez E, Huangfu D, Raya A. CRISPR/Cas9-Based Engineering of the Epigenome. Cell Stem Cell. 2017 10 05; 21(4):431-447. PMID: 28985525.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Shi ZD, Soh CL, Zhu Z, Huangfu D. Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development. J Vis Exp. 2017 03 05; (121). PMID: 28287608.
    Citations:    Fields:    Translation:HumansCells
  15. Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2017 05 04; 20(5):675-688.e6. PMID: 28196600.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Soh CL, Huangfu D. CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem Cells in Defined Xeno-Free E8 Medium. Methods Mol Biol. 2017; 1498:57-78. PMID: 27709569.
    Citations: 1     Fields:    Translation:HumansCells
  17. Verma N, Zhu Z, Huangfu D. CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells. Methods Mol Biol. 2017; 1513:119-140. PMID: 27807834.
    Citations: 1     Fields:    Translation:HumansCells
  18. Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017 01 05; 20(1):70-86. PMID: 27889317.
    Citations: 13     Fields:    Translation:AnimalsCells
  19. Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D. Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell. 2016 06 02; 18(6):755-68. PMID: 27133796.
    Citations: 16     Fields:    Translation:HumansCells
  20. González F, Huangfu D. Mechanisms underlying the formation of induced pluripotent stem cells. Wiley Interdiscip Rev Dev Biol. 2016 Jan-Feb; 5(1):39-65. PMID: 26383234.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Zhu Z, Verma N, González F, Shi ZD, Huangfu D. A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells. Stem Cell Reports. 2015 Jun 09; 4(6):1103-11. PMID: 26028531.
    Citations: 27     Fields:    Translation:HumansCells
  22. Kotini AG, Chang CJ, Boussaad I, Delrow JJ, Dolezal EK, Nagulapally AB, Perna F, Fishbein GA, Klimek VM, Hawkins RD, Huangfu D, Murry CE, Graubert T, Nimer SD, Papapetrou EP. Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells. Nat Biotechnol. 2015 Jun; 33(6):646-55. PMID: 25798938.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  23. González F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D. An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells. Cell Stem Cell. 2014 Aug 07; 15(2):215-226. PMID: 24931489.
    Citations: 95     Fields:    Translation:HumansCells
  24. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 05; 14(6):706-9. PMID: 25032261.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Zhu Z, González F, Huangfu D. The iCRISPR platform for rapid genome editing in human pluripotent stem cells. Methods Enzymol. 2014; 546:215-50. PMID: 25398343.
    Citations: 20     Fields:    Translation:HumansCells
  26. González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D. Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep. 2013 Mar 28; 3(3):651-60. PMID: 23478019.
    Citations: 29     Fields:    Translation:AnimalsCells
  27. Zhu Z, Huangfu D. Human pluripotent stem cells: an emerging model in developmental biology. Development. 2013 Feb; 140(4):705-17. PMID: 23362344.
    Citations: 31     Fields:    Translation:HumansCells
  28. Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y. Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development. 2010 Oct; 137(19):3205-13. PMID: 20823063.
    Citations: 32     Fields:    Translation:AnimalsCells
  29. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. PMID: 19818703.
    Citations: 256     Fields:    Translation:AnimalsCells
  30. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008 Nov; 26(11):1269-75. PMID: 18849973.
    Citations: 452     Fields:    Translation:HumansAnimalsCells
  31. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008 Jul; 26(7):795-7. PMID: 18568017.
    Citations: 528     Fields:    Translation:AnimalsCells
  32. Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. PLoS Biol. 2007 Jul; 5(7):e163. PMID: 17535113.
    Citations: 90     Fields:    Translation:AnimalsCells
  33. Huangfu D, Anderson KV. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development. 2006 Jan; 133(1):3-14. PMID: 16339192.
    Citations: 170     Fields:    Translation:AnimalsCells
  34. Huangfu D, Anderson KV. Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11325-30. PMID: 16061793.
    Citations: 308     Fields:    Translation:AnimalsCells
  35. García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):5913-9. PMID: 15755804.
    Citations: 58     Fields:    Translation:Animals
  36. Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 06; 426(6962):83-7. PMID: 14603322.
    Citations: 449     Fields:    Translation:AnimalsCells
  37. Caspary T, García-García MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL, Anderson KV. Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol. 2002 Sep 17; 12(18):1628-32. PMID: 12372258.
    Citations: 45     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.