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John Weyl Winkelman, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DA052861 (WINKELMAN, JOHN W) Mar 15, 2021 - Feb 28, 2023
    NIH
    Treatment of Restless Legs Symptoms with Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD: A Pilot Double-blind, Randomized Clinical Trial
    Role: Principal Investigator
  2. R01MH095792 (WINKELMAN, JOHN W) Aug 1, 2012 - Mar 31, 2018
    NIH
    Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    Role: Principal Investigator
  3. M01RR002635 (GOTTLIEB, GARY L) Dec 1, 1984 - Mar 31, 2010
    NIH
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bogan R, Thorpy MJ, Winkelman JW, Dubow J, Gudeman J, Seiden D. Randomized, crossover, open-label study of the relative bioavailability and safety of FT218, a once-nightly sodium oxybate formulation: Phase 1 study in healthy volunteers. Sleep Med. 2022 12; 100:442-447. PMID: 36252412.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  2. Salminen AV, Clemens S, García-Borreguero D, Ghorayeb I, Li Y, Manconi M, Ondo W, Rye D, Siegel JM, Silvani A, Winkelman JW, Allen RP, Ferré S. Consensus guidelines on the construct validity of rodent models of restless legs syndrome. Dis Model Mech. 2022 08 01; 15(8). PMID: 35946581; PMCID: PMC9393041.
    Citations: 1     Fields:    Translation:Animals
  3. Yeung Laiwah J, Winkelman JW. How effective are treatment guidelines for augmented RLS? Sleep. 2022 07 11; 45(7). PMID: 35532181.
    Citations:    Fields:    Translation:Humans
  4. Winkelman JW. Treating Severe Refractory and Augmented Restless Legs Syndrome. Chest. 2022 09; 162(3):693-700. PMID: 35609673.
    Citations:    Fields:    
  5. Nassan M, Daghlas I, Winkelman JW, Dashti HS, Saxena R. Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study. Neuropsychopharmacology. 2022 08; 47(9):1672-1679. PMID: 35538198; PMCID: PMC9283512.
    Citations:    Fields:    Translation:Humans
  6. Cho SE, Kang JM, Ko KP, Lim WJ, Redline S, Winkelman JW, Kang SG. Association Between Subjective-Objective Discrepancy of Sleeping Time and Health-Related Quality of Life: A Community-Based Polysomnographic Study. Psychosom Med. 2022 05 01; 84(4):505-512. PMID: 35321997; PMCID: PMC9064942.
    Citations:    Fields:    Translation:Humans
  7. Rahman SA, Nathan MD, Wiley A, Crawford S, Cohn AY, Harder JA, Grant LK, Erickson A, Srivastava A, McCormick K, Bertisch SM, Winkelman JW, Joffe H. A double-blind, randomized, placebo-controlled trial of suvorexant for the treatment of vasomotor symptom-associated insomnia disorder in midlife women. Sleep. 2022 03 14; 45(3). PMID: 35022783.
    Citations:    Fields:    Translation:Humans
  8. Winkelman JW, Grant NR, Molay F, Stephen CD, Sadjadi R, Eichler FS. Restless Legs Syndrome in X-linked adrenoleukodystrophy. Sleep Med. 2022 03; 91:31-34. PMID: 35245789; PMCID: PMC9035065.
    Citations: 1     Fields:    Translation:Humans
  9. Winkelman JW. High national rates of high-dose dopamine agonist prescribing for restless legs syndrome. Sleep. 2022 02 14; 45(2). PMID: 34417810; PMCID: PMC8842153.
    Citations:    Fields:    Translation:Humans
  10. Eddie D, Bentley KH, Bernard R, Mischoulon D, Winkelman JW. Aggregating heart rate variability indices across sleep stage epochs ignores significant variance through the night. Sleep Med. 2022 02; 90:262-266. PMID: 35228137; PMCID: PMC8923916.
    Citations:    Fields:    Translation:Humans
  11. Wipper B, Romero-Gutierrez C, Winkelman JW. Restless legs syndrome severity in the National RLS Opioid Registry during the COVID-19 pandemic. Sleep Med. 2022 02; 90:96-101. PMID: 35131547; PMCID: PMC8783980.
    Citations:    Fields:    Translation:HumansPHPublic Health
  12. Zak RS, Winkelman JW. Sleep questionnaire copyright fees can benefit research: a response to Chiang and Folz. Sleep. 2021 12 10; 44(12). PMID: 34726232.
    Citations:    Fields:    
  13. Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clin Proc. 2021 07; 96(7):1921-1937. PMID: 34218864.
    Citations: 4     Fields:    Translation:Humans
  14. Zhuang S, Yuan X, Ma C, Yang N, Liu CF, Na M, Winkelman JW, Wu S, Gao X. Restless legs syndrome and perceived olfactory and taste dysfunction: A community-based study. Eur J Neurol. 2021 08; 28(8):2688-2693. PMID: 33932063.
    Citations:    Fields:    Translation:Humans
  15. Wipper B, Winkelman JW. The Long-Term Psychiatric and Cardiovascular Morbidity and Mortality of Restless Legs Syndrome and Periodic Limb Movements of Sleep. Sleep Med Clin. 2021 Jun; 16(2):279-288. PMID: 33985653.
    Citations: 2     Fields:    Translation:Humans
  16. Fulda S, Allen RP, Earley CJ, Högl B, Garcia-Borreguero D, Inoue Y, Ondo W, Walters AS, Williams AM, Winkelman JW. We need to do better: A systematic review and meta-analysis of diagnostic test accuracy of restless legs syndrome screening instruments. Sleep Med Rev. 2021 08; 58:101461. PMID: 33838561.
    Citations: 3     Fields:    Translation:Humans
  17. Winkelman JW, Purks J, Wipper B. Baseline and 1-year longitudinal data from the National Restless Legs Syndrome Opioid Registry. Sleep. 2021 02 12; 44(2). PMID: 32918469.
    Citations: 3     Fields:    Translation:Humans
  18. Morin CM, Inoue Y, Kushida C, Poyares D, Winkelman J. Endorsement of European guideline for the diagnosis and treatment of insomnia by the World Sleep Society. Sleep Med. 2021 05; 81:124-126. PMID: 33667998.
    Citations: 1     Fields:    Translation:Humans
  19. Salminen AV, Silvani A, Allen RP, Clemens S, Garcia-Borreguero D, Ghorayeb I, Ferré S, Li Y, Ondo W, Picchietti DL, Rye D, Siegel JM, Winkelman JW, Manconi M. Consensus Guidelines on Rodent Models of Restless Legs Syndrome. Mov Disord. 2021 03; 36(3):558-569. PMID: 33382140; PMCID: PMC8313425.
    Citations:    Fields:    Translation:Animals
  20. Roth T, Winkelman JW. Recognizing and Treating Excessive Daytime Sleepiness in Patients With Narcolepsy. J Clin Psychiatry. 2020 11 24; 81(6). PMID: 33238081.
    Citations:    Fields:    Translation:Humans
  21. Winkelman JW, Wipper B, Purks J, Mei L, Schoerning L. Topiramate reduces nocturnal eating in sleep-related eating disorder. Sleep. 2020 09 14; 43(9). PMID: 32227216.
    Citations: 2     Fields:    Translation:Humans
  22. Chen TY, Winkelman JW, Mao WC, Tzeng NS, Kuo TBJ, Yang CCH, Tsai HJ, Wu CS. Real-world evidence on the use of benzodiazepine receptor agonists and the risk of venous thromboembolism. J Thromb Haemost. 2020 11; 18(11):2878-2888. PMID: 32741123.
    Citations: 1     Fields:    Translation:Humans
  23. Winkelman JW. Screening for Excessive Daytime Sleepiness and Diagnosing Narcolepsy. J Clin Psychiatry. 2020 07 21; 81(4). PMID: 32726523.
    Citations:    Fields:    Translation:Humans
  24. Benson KL, Bottary R, Schoerning L, Baer L, Gonenc A, Eric Jensen J, Winkelman JW. 1H MRS Measurement of Cortical GABA and Glutamate in Primary Insomnia and Major Depressive Disorder: Relationship to Sleep Quality and Depression Severity. J Affect Disord. 2020 09 01; 274:624-631. PMID: 32663996.
    Citations: 8     Fields:    Translation:Humans
  25. Kang JM, Kim ST, Mariani S, Cho SE, Winkelman JW, Park KH, Kang SG. Difference in spectral power density of sleep EEG between patients with simple snoring and those with obstructive sleep apnoea. Sci Rep. 2020 04 09; 10(1):6135. PMID: 32273528.
    Citations: 4     Fields:    Translation:Humans
  26. Eddie D, Bentley KH, Bernard R, Yeung A, Nyer M, Pedrelli P, Mischoulon D, Winkelman JW. Major depressive disorder and insomnia: Exploring a hypothesis of a common neurological basis using waking and sleep-derived heart rate variability. J Psychiatr Res. 2020 04; 123:89-94. PMID: 32044591.
    Citations: 3     Fields:    Translation:Humans
  27. Winkelman JW. How to Identify and Fix Sleep Problems: Better Sleep, Better Mental Health. JAMA Psychiatry. 2020 01 01; 77(1):99-100. PMID: 31774491.
    Citations: 2     Fields:    Translation:Humans
  28. May AM, May RD, Bena J, Wang L, Monahan K, Stone KL, Barrett-Connor E, Koo BB, Winkelman JW, Redline S, Mittleman MA, Mehra R. Individual periodic limb movements with arousal are temporally associated with nonsustained ventricular tachycardia: a case-crossover analysis. Sleep. 2019 10 21; 42(11). PMID: 31585012.
    Citations: 2     Fields:    Translation:Humans
  29. During EH, Winkelman JW. Drug Treatment of Restless Legs Syndrome in Older Adults. Drugs Aging. 2019 10; 36(10):939-946. PMID: 31347095.
    Citations:    Fields:    Translation:Humans
  30. Winkelman JW, Lecea L. Sleep and neuropsychiatric illness. Neuropsychopharmacology. 2020 01; 45(1):1-2. PMID: 31486776.
    Citations: 3     Fields:    Translation:Humans
  31. Zhuang S, Na M, Winkelman JW, Ba D, Liu CF, Liu G, Gao X. Association of Restless Legs Syndrome With Risk of Suicide and Self-harm. JAMA Netw Open. 2019 08 02; 2(8):e199966. PMID: 31441941; PMCID: PMC6714009.
    Citations: 11     Fields:    Translation:Humans
  32. Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. J Clin Invest. 2019 03 26; 129(7):2730-2744. PMID: 30913037; PMCID: PMC6597217.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  33. Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 03; 51(3):387-393. PMID: 30804566; PMCID: PMC6415688.
    Citations: 64     Fields:    Translation:HumansCells
  34. Chen TY, Winkelman JW, Mao WC, Yeh CB, Huang SY, Kao TW, Yang CCH, Kuo TBJ, Chen WL. Short Sleep Duration Is Associated With Increased Serum Homocysteine: Insights From a National Survey. J Clin Sleep Med. 2019 01 15; 15(1):139-148. PMID: 30621835; PMCID: PMC6329535.
    Citations: 4     Fields:    Translation:Humans
  35. Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J. Reply to: A note on rotigotine for restless legs syndrome after renal transplantation. Mov Disord. 2019 01; 34(1):152-153. PMID: 30653726.
    Citations:    Fields:    Translation:Humans
  36. Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J. Reply to: Safety of dopamine agonists for treating restless legs syndrome. Mov Disord. 2019 01; 34(1):150-151. PMID: 30653723.
    Citations:    Fields:    Translation:Humans
  37. McCall CA, Winkelman JW. Respiratory-Related Leg Movements of Sleep Are Associated With Serotonergic Antidepressants But Not Bupropion. J Clin Sleep Med. 2018 09 15; 14(9):1569-1576. PMID: 30176966.
    Citations:    Fields:    Translation:Humans
  38. Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW. In Reply-Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome. Mayo Clin Proc. 2018 07; 93(7):955-956. PMID: 29976378.
    Citations:    Fields:    Translation:Humans
  39. Winkelmann J, Allen RP, Högl B, Inoue Y, Oertel W, Salminen AV, Winkelman JW, Trenkwalder C, Sampaio C. Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§. Mov Disord. 2018 07; 33(7):1077-1091. PMID: 29756335.
    Citations: 34     Fields:    Translation:Humans
  40. Winkelman JW, Jaros MJ. Predictors of clinical response in a double-blind placebo controlled crossover trial of gabapentin enacarbil for restless legs syndrome. Sleep Med. 2018 08; 48:1-7. PMID: 29807228.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  41. Kang SG, Mariani S, Marvin SA, Ko KP, Redline S, Winkelman JW. Sleep EEG spectral power is correlated with subjective-objective discrepancy of sleep onset latency in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2018 07 13; 85:122-127. PMID: 29680498.
    Citations: 5     Fields:    Translation:Humans
  42. Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW. The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome. Mayo Clin Proc. 2018 01; 93(1):59-67. PMID: 29304922.
    Citations: 12     Fields:    Translation:Humans
  43. Li Y, Li Y, Winkelman JW, Walters AS, Han J, Hu FB, Gao X. Prospective study of restless legs syndrome and total and cardiovascular mortality among women. Neurology. 2018 01 09; 90(2):e135-e141. PMID: 29247069.
    Citations: 20     Fields:    Translation:Humans
  44. Moonga SS, Mischoulon D, Winkelman JW, Stern TA. Obstructive Sleep Apnea as a Complication of Bipolar Disorder and Its Treatment: A Review and Approach to Management. Prim Care Companion CNS Disord. 2017 Nov 30; 19(6). PMID: 29195035.
    Citations:    Fields:    Translation:Humans
  45. Allen RP, Picchietti DL, Auerbach M, Cho YW, Connor JR, Earley CJ, Garcia-Borreguero D, Kotagal S, Manconi M, Ondo W, Ulfberg J, Winkelman JW. Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Med. 2018 01; 41:27-44. PMID: 29425576.
    Citations: 35     Fields:    Translation:Humans
  46. Chen TY, Winkelman JW, Mao WC, Liu CL, Hsu CY, Wu CS. The Use of Benzodiazepine Receptor Agonists and the Risk of Hospitalization for Pneumonia: A Nationwide Population-Based Nested Case-Control Study. Chest. 2018 01; 153(1):161-171. PMID: 28782528.
    Citations: 12     Fields:    Translation:Humans
  47. Mackie SE, Winkelman JW. Therapeutic Utility of Opioids for Restless Legs Syndrome. Drugs. 2017 Aug; 77(12):1337-1344. PMID: 28616844.
    Citations: 2     Fields:    Translation:Humans
  48. Buxton OM, Pavlova MK, O'Connor SP, Wang W, Winkelman JW. Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients. Nat Sci Sleep. 2017; 9:187-198. PMID: 28790874; PMCID: PMC5530064.
    Citations: 5     
  49. Allen RP, Armstrong MJ, Trenkwalder C, Zee PC, Winkelman JW. Author response: Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 06 13; 88(24):2337-2338. PMID: 28607140.
    Citations:    Fields:    Translation:Humans
  50. Grandner MA, Winkelman JW. Nocturnal leg cramps: Prevalence and associations with demographics, sleep disturbance symptoms, medical conditions, and cardiometabolic risk factors. PLoS One. 2017; 12(6):e0178465. PMID: 28586374; PMCID: PMC5460850.
    Citations: 3     Fields:    Translation:Humans
  51. Gottlieb DJ, Somers VK, Punjabi NM, Winkelman JW. Restless legs syndrome and cardiovascular disease: a research roadmap: A response. Sleep Med. 2017 08; 36:181. PMID: 28596082.
    Citations: 2     Fields:    Translation:Humans
  52. Kang SG, Kang JM, Cho SJ, Ko KP, Lee YJ, Lee HJ, Kim L, Winkelman JW. Cognitive Behavioral Therapy Using a Mobile Application Synchronizable With Wearable Devices for Insomnia Treatment: A Pilot Study. J Clin Sleep Med. 2017 Apr 15; 13(4):633-640. PMID: 28162145.
    Citations: 13     Fields:    Translation:Humans
  53. Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Redline S. Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic Leg Movements of Sleep in Older Men, for the Outcomes of Sleep Disorders in Older Men Study (MrOS Sleep Study). Sleep. 2017 04 01; 40(4). PMID: 28199705.
    Citations: 18     Fields:    Translation:Humans
  54. Winkelman JW, Armstrong MJ, Allen RP, Chaudhuri KR, Ondo W, Trenkwalder C, Zee PC, Gronseth GS, Gloss D, Zesiewicz T. Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2016 Dec 13; 87(24):2585-2593. PMID: 27856776.
    Citations: 39     Fields:    Translation:Humans
  55. Gottlieb DJ, Somers VK, Punjabi NM, Winkelman JW. Restless legs syndrome and cardiovascular disease: a research roadmap. Sleep Med. 2017 03; 31:10-17. PMID: 28065687; PMCID: PMC5334194.
    Citations: 24     Fields:    Translation:HumansAnimals
  56. Mackie SE, McHugh RK, McDermott K, Griffin ML, Winkelman JW, Weiss RD. Prevalence of restless legs syndrome during detoxification from alcohol and opioids. J Subst Abuse Treat. 2017 02; 73:35-39. PMID: 28017182.
    Citations: 3     Fields:    Translation:Humans
  57. Cheng FW, Li Y, Winkelman JW, Hu FB, Rimm EB, Gao X. Probable insomnia is associated with future total energy intake and diet quality in men. Am J Clin Nutr. 2016 08; 104(2):462-9. PMID: 27413124; PMCID: PMC4962161.
    Citations: 13     Fields:    Translation:HumansAnimals
  58. Winkelman JW, Mackie SE, Mei LA, Platt S, Schoerning L. A method to switch from oral dopamine agonists to rotigotine in patients with restless legs syndrome and mild augmentation. Sleep Med. 2016 08; 24:18-23. PMID: 27810181.
    Citations: 1     Fields:    Translation:Humans
  59. Bauer A, Cassel W, Benes H, Kesper K, Rye D, Sica D, Winkelman JW, Bauer L, Grieger F, Joeres L, Moran K, Schollmayer E, Whitesides J, Carney HC, Walters AS, Oertel W, Trenkwalder C. Rotigotine's effect on PLM-associated blood pressure elevations in restless legs syndrome: An RCT. Neurology. 2016 May 10; 86(19):1785-93. PMID: 27164714; PMCID: PMC4862252.
    Citations: 12     Fields:    Translation:Humans
  60. Bertisch SM, Muresan C, Schoerning L, Winkelman JW, Taylor JA. Impact of Restless Legs Syndrome on Cardiovascular Autonomic Control. Sleep. 2016 Mar 01; 39(3):565-71. PMID: 26564128.
    Citations: 18     Fields:    Translation:Humans
  61. Garcia-Borreguero D, Silber MH, Winkelman JW, Högl B, Bainbridge J, Buchfuhrer M, Hadjigeorgiou G, Inoue Y, Manconi M, Oertel W, Ondo W, Winkelmann J, Allen RP. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016 05; 21:1-11. PMID: 27448465.
    Citations: 58     Fields:    Translation:Humans
  62. Tuohy CV, Montez-Rath ME, Turakhia M, Chang TI, Winkelman JW, Winkelmayer WC. Sleep disordered breathing and cardiovascular risk in older patients initiating dialysis in the United States: a retrospective observational study using medicare data. BMC Nephrol. 2016 Feb 09; 17:16. PMID: 26861778.
    Citations: 8     Fields:    Translation:Humans
  63. Dauvilliers Y, Benes H, Partinen M, Rauta V, Rifkin D, Dohin E, Goldammer N, Schollmayer E, Schröder H, Winkelman JW. Rotigotine in Hemodialysis-Associated Restless Legs Syndrome: A Randomized Controlled Trial. Am J Kidney Dis. 2016 Sep; 68(3):434-43. PMID: 26851201.
    Citations: 7     Fields:    Translation:Humans
  64. Batool-Anwar S, Li Y, De Vito K, Malhotra A, Winkelman J, Gao X. Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study. J Clin Sleep Med. 2016 Feb; 12(2):187-94. PMID: 26446243.
    Citations: 9     Fields:    Translation:Humans
  65. Li Y, Gao X, Winkelman JW, Cespedes EM, Jackson CL, Walters AS, Schernhammer E, Redline S, Hu FB. Association between sleeping difficulty and type 2 diabetes in women. Diabetologia. 2016 Apr; 59(4):719-27. PMID: 26818148.
    Citations: 12     Fields:    Translation:Humans
  66. Garcia-Borreguero D, Allen R, Hudson J, Dohin E, Grieger F, Moran K, Schollmayer E, Smit R, Winkelman J. Effects of rotigotine on daytime symptoms in patients with primary restless legs syndrome: a randomized, placebo-controlled study. Curr Med Res Opin. 2016; 32(1):77-85. PMID: 26569149.
    Citations: 4     Fields:    Translation:Humans
  67. Winkelman JW. Response to Letter to the Editor: "Ferritin deficiency may deteriorate the symptoms of Restless Legs Syndrome". Sleep Med. 2016 06; 22:105. PMID: 26586594.
    Citations:    Fields:    
  68. Winkelman JW. CLINICAL PRACTICE. Insomnia Disorder. N Engl J Med. 2015 Oct 08; 373(15):1437-44. PMID: 26444730.
    Citations: 52     Fields:    Translation:Humans
  69. Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Tranah GJ, Redline S. Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study. Sleep Med. 2015 Nov; 16(11):1360-1365. PMID: 26498236; PMCID: PMC4621485.
    Citations: 4     Fields:    Translation:Humans
  70. Novak M, Winkelman JW, Unruh M. Restless Legs Syndrome in Patients With Chronic Kidney Disease. Semin Nephrol. 2015 Jul; 35(4):347-58. PMID: 26355253.
    Citations: 22     Fields:    Translation:Humans
  71. Aritake S, Blackwell T, Peters KW, Rueschman M, Mobley D, Morrical MG, Platt SF, Dam TT, Redline S, Winkelman JW. Prevalence and associations of respiratory-related leg movements: the MrOS sleep study. Sleep Med. 2015 Oct; 16(10):1236-44. PMID: 26429752; PMCID: PMC4665997.
    Citations: 8     Fields:    Translation:Humans
  72. Mackie S, Winkelman JW. Restless Legs Syndrome and Psychiatric Disorders. Sleep Med Clin. 2015 Sep; 10(3):351-7, xv. PMID: 26329445.
    Citations: 3     Fields:    Translation:Humans
  73. Mackie S, Winkelman JW. Long-Term Treatment of Restless Legs Syndrome (RLS): An Approach to Management of Worsening Symptoms, Loss of Efficacy, and Augmentation. CNS Drugs. 2015 May; 29(5):351-7. PMID: 26045290.
    Citations: 5     Fields:    Translation:Humans
  74. Manconi M, Zavalko I, Fanfulla F, Winkelman JW, Fulda S. An evidence-based recommendation for a new definition of respiratory-related leg movements. Sleep. 2015 Feb 01; 38(2):295-304. PMID: 25325500.
    Citations: 11     Fields:    Translation:Humans
  75. Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, Allen R. Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease). Sleep Med. 2014 Nov; 15(11):1288-301. PMID: 25201131.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  76. Winkelman JW, Schoerning L, Platt S, Jensen JE. Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity. Sleep Med. 2014 Oct; 15(10):1225-30. PMID: 25129262.
    Citations: 11     Fields:    Translation:Humans
  77. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014 Aug; 15(8):860-73. PMID: 25023924.
    Citations: 301     Fields:    Translation:Humans
  78. Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, Knapp L, Winkelman JW. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014 Feb 13; 370(7):621-31. PMID: 24521108.
    Citations: 44     Fields:    Translation:Humans
  79. Bertisch SM, Herzig SJ, Winkelman JW, Buettner C. National use of prescription medications for insomnia: NHANES 1999-2010. Sleep. 2014 Feb 01; 37(2):343-9. PMID: 24497662.
    Citations: 103     Fields:    Translation:Humans
  80. Li Y, Zhang X, Winkelman JW, Redline S, Hu FB, Stampfer M, Ma J, Gao X. Association between insomnia symptoms and mortality: a prospective study of U.S. men. Circulation. 2014 Feb 18; 129(7):737-46. PMID: 24226807; PMCID: PMC3987964.
    Citations: 84     Fields:    Translation:Humans
  81. Spiegelhalder K, Regen W, Baglioni C, Riemann D, Winkelman JW. Neuroimaging studies in insomnia. Curr Psychiatry Rep. 2013 Nov; 15(11):405. PMID: 24057158.
    Citations: 18     Fields:    Translation:Humans
  82. Yang MS, Montplaisir J, Desautels A, Winkelman JW, Cramer Bornemann MA, Earley CJ, Allen RP. Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording. Sleep Med. 2014 Jan; 15(1):132-7. PMID: 24332046.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  83. Winkelman JW, Gagnon A, Clair AG. Sensory symptoms in restless legs syndrome: the enigma of pain. Sleep Med. 2013 Oct; 14(10):934-42. PMID: 23948222.
    Citations: 10     Fields:    Translation:Humans
  84. Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton OM, O'Connor SP, Jensen JE, Renshaw PF, Gonenc A. Increased Rostral Anterior Cingulate Cortex Volume in Chronic Primary Insomnia. Sleep. 2013 Jul 01; 36(7):991-998. PMID: 23814335; PMCID: PMC3669070.
    Citations: 52     Fields:    
  85. Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Högl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Med. 2013 Jul; 14(7):675-84. PMID: 23859128.
    Citations: 66     Fields:    Translation:Humans
  86. Li Y, Wang W, Winkelman JW, Malhotra A, Ma J, Gao X. Prospective study of restless legs syndrome and mortality among men. Neurology. 2013 Jul 02; 81(1):52-9. PMID: 23761622; PMCID: PMC3770202.
    Citations: 30     Fields:    Translation:Humans
  87. Mackie S, Winkelman JW. Normal ferritin in a patient with iron deficiency and RLS. J Clin Sleep Med. 2013 May 15; 9(5):511-3. PMID: 23674944; PMCID: PMC3629327.
    Citations: 4     Fields:    Translation:Humans
  88. Winkelman JW. Is restless legs syndrome a sleep disorder? Neurology. 2013 May 28; 80(22):2006-7. PMID: 23624567.
    Citations: 1     Fields:    Translation:HumansCells
  89. Harper DG, Plante DT, Jensen JE, Ravichandran C, Buxton OM, Benson KL, O'Connor SP, Renshaw PF, Winkelman JW. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla. Sleep. 2013 Apr 01; 36(4):493-500. PMID: 23564996.
    Citations: 12     Fields:    Translation:HumansCells
  90. Deak MC, Winkelman JW. Insomnia. Neurol Clin. 2012 Nov; 30(4):1045-66. PMID: 23099129.
    Citations: 2     Fields:    Translation:Humans
  91. Lin WC, Winkelman JW. Obstructive sleep apnea and severe mental illness: evolution and consequences. Curr Psychiatry Rep. 2012 Oct; 14(5):503-10. PMID: 22872493.
    Citations: 11     Fields:    Translation:Humans
  92. Li Y, Walters AS, Chiuve SE, Rimm EB, Winkelman JW, Gao X. Prospective study of restless legs syndrome and coronary heart disease among women. Circulation. 2012 Oct 02; 126(14):1689-94. PMID: 22967852; PMCID: PMC3493117.
    Citations: 55     Fields:    Translation:Humans
  93. Li Y, Mirzaei F, O'Reilly EJ, Winkelman J, Malhotra A, Okereke OI, Ascherio A, Gao X. Prospective study of restless legs syndrome and risk of depression in women. Am J Epidemiol. 2012 Aug 15; 176(4):279-88. PMID: 22805376.
    Citations: 25     Fields:    Translation:Humans
  94. Plante DT, Jensen JE, Winkelman JW. The role of GABA in primary insomnia. Sleep. 2012 Jun 01; 35(6):741-2. PMID: 22654187.
    Citations: 13     Fields:    Translation:Humans
  95. Plante DT, Jensen JE, Schoerning L, Winkelman JW. Reduced ?-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? Neuropsychopharmacology. 2012 May; 37(6):1548-57. PMID: 22318195.
    Citations: 51     Fields:    Translation:Humans
  96. García-Borreguero D, Högl B, Ferini-Strambi L, Winkelman J, Hill-Zabala C, Asgharian A, Allen R. Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (Willis-Ekbom disease): results from a prospective, multicenter study over 66 weeks. Mov Disord. 2012 Feb; 27(2):277-83. PMID: 22328464.
    Citations: 11     Fields:    Translation:Humans
  97. Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle-aged women. Hypertension. 2011 Nov; 58(5):791-6. PMID: 21986505.
    Citations: 34     Fields:    Translation:Humans
  98. Winkelman JW, Bogan RK, Schmidt MH, Hudson JD, DeRossett SE, Hill-Zabala CE. Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome. Mov Disord. 2011 Sep; 26(11):2065-72. PMID: 21611981.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  99. Winkelman JW, Johnson EA, Richards LM. Sleep-related eating disorder. Handb Clin Neurol. 2011; 98:577-85. PMID: 21056212.
    Citations: 5     Fields:    Translation:Humans
  100. Duffy JF, Lowe AS, Silva EJ, Winkelman JW. Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night. Sleep Med. 2011 Jan; 12(1):83-8. PMID: 21093364.
    Citations: 8     Fields:    Translation:Humans
  101. Yang C, Winkelman JW. Clinical and polysomnographic characteristics of high frequency leg movements. J Clin Sleep Med. 2010 Oct 15; 6(5):431-8. PMID: 20957842.
    Citations: 4     Fields:    Translation:Humans
  102. Hening WA, Allen RP, Ondo WG, Walters AS, Winkelman JW, Becker P, Bogan R, Fry JM, Kudrow DB, Lesh KW, Fichtner A, Schollmayer E. Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. Mov Disord. 2010 Aug 15; 25(11):1675-83. PMID: 20629075.
    Citations: 25     Fields:    Translation:Humans
  103. Winkelman JW, Benson KL, Buxton OM, Lyoo IK, Yoon S, O'Connor S, Renshaw PF. Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med. 2010 Jun; 11(6):576-82. PMID: 20466585.
    Citations: 45     Fields:    Translation:Humans
  104. Winkelman JW. The diagnosis and work-up of insomnia. CNS Spectr. 2009 Dec; 14(12 Suppl 13):4-6. PMID: 20448511.
    Citations:    Fields:    Translation:Humans
  105. Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. Sleep. 2009 Jun; 32(6):772-8. PMID: 19544754.
    Citations: 42     Fields:    Translation:Humans
  106. Winkelman JW, Buxton OM, Jensen JE, Benson KL, O'Connor SP, Wang W, Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008 Nov; 31(11):1499-506. PMID: 19014069.
    Citations: 52     Fields:    Translation:HumansCells
  107. Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry. 2008 Jul; 165(7):830-43. PMID: 18483132.
    Citations: 63     Fields:    Translation:Humans
  108. Winkelman JW, Shahar E, Sharief I, Gottlieb DJ. Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. Neurology. 2008 Jan 01; 70(1):35-42. PMID: 18166705.
    Citations: 111     Fields:    Translation:Humans
  109. Winkelman JW, Allen RP, Tenzer P, Hening W. Restless legs syndrome: nonpharmacologic and pharmacologic treatments. Geriatrics. 2007 Oct; 62(10):13-6. PMID: 17922563.
    Citations: 2     Fields:    Translation:Humans
  110. Hening W, Allen RP, Tenzer P, Winkelman JW. Restless legs syndrome: demographics, presentation, and differential diagnosis. Geriatrics. 2007 Sep; 62(9):26-9. PMID: 17824723.
    Citations: 11     Fields:    Translation:Humans
  111. Winkelman JW. Periodic limb movements in sleep--endophenotype for restless legs syndrome? N Engl J Med. 2007 Aug 16; 357(7):703-5. PMID: 17634452.
    Citations: 20     Fields:    Translation:Humans
  112. Garcia-Borreguero D, Winkelman J, Adams A, Ellis A, Morris M, Lamb J, Layton G, Versavel M. Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study. Sleep Med. 2007 Mar; 8(2):119-27. PMID: 17239657.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  113. Winkelman JW. A better future for patients with restless legs syndrome. Am J Med. 2007 Jan; 120(1 Suppl 1):S28-9. PMID: 17198768.
    Citations: 2     Fields:    Translation:Humans
  114. Hening WA, Allen RP, Chaudhuri KR, Hornyak M, Lee HB, Winkelman J, Yoakum R. Clinical significance of RLS. Mov Disord. 2007; 22 Suppl 18:S395-400. PMID: 18081162.
    Citations: 12     Fields:    Translation:Humans
  115. Plante DT, Winkelman JW. Parasomnias. Psychiatr Clin North Am. 2006 Dec; 29(4):969-87; abstract ix. PMID: 17118277.
    Citations: 5     Fields:    Translation:Humans
  116. Winkelman JW. Efficacy and tolerability of open-label topiramate in the treatment of sleep-related eating disorder: a retrospective case series. J Clin Psychiatry. 2006 Nov; 67(11):1729-34. PMID: 17196052.
    Citations: 15     Fields:    Translation:Humans
  117. Winkelman JW. Sleep-related eating disorder and night eating syndrome: sleep disorders, eating disorders, or both? Sleep. 2006 Jul; 29(7):876-7. PMID: 16895252.
    Citations: 15     Fields:    Translation:Humans
  118. Winkelman JW, Finn L, Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med. 2006 Oct; 7(7):545-52. PMID: 16740407.
    Citations: 83     Fields:    Translation:Humans
  119. Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory events with or without leg movements. Sleep. 2006 Apr; 29(4):553-6. PMID: 16676789.
    Citations: 15     Fields:    Translation:Humans
  120. Yang C, Winkelman JW. Clinical significance of sleep EEG abnormalities in chronic schizophrenia. Schizophr Res. 2006 Feb 28; 82(2-3):251-60. PMID: 16377158.
    Citations: 34     Fields:    Translation:Humans
  121. Yang C, White DP, Winkelman JW. Antidepressants and periodic leg movements of sleep. Biol Psychiatry. 2005 Sep 15; 58(6):510-4. PMID: 16005440.
    Citations: 43     Fields:    Translation:HumansCTClinical Trials
  122. Picchietti D, Winkelman JW. Restless legs syndrome, periodic limb movements in sleep, and depression. Sleep. 2005 Jul; 28(7):891-8. PMID: 16124671.
    Citations: 40     Fields:    Translation:Humans
  123. Winkelman J, Pies R. Current patterns and future directions in the treatment of insomnia. Ann Clin Psychiatry. 2005 Jan-Mar; 17(1):31-40. PMID: 15941029.
    Citations: 8     Fields:    Translation:Humans
  124. Winkelman JW. Education designing a sleep disorders curriculum for psychiatry residents. Harv Rev Psychiatry. 2005 Jan-Feb; 13(1):54-6. PMID: 15804934.
    Citations: 1     Fields:    Translation:Humans
  125. Winkelman J. A novel combination therapy for primary insomnia? Sleep. 2004 Jun 15; 27(4):604-5. PMID: 15282993.
    Citations:    Fields:    Translation:Humans
  126. Winkelman JW, James L. Serotonergic antidepressants are associated with REM sleep without atonia. Sleep. 2004 Mar 15; 27(2):317-21. PMID: 15124729.
    Citations: 62     Fields:    Translation:Humans
  127. Stickgold RA, Winkelman JW, Wehrwein P. You will start to feel very sleepy.... ...And you should go to bed, because shortchanging your rest can hurt your health. Newsweek. 2004 Jan 19; 143(3):58, 60. PMID: 14959585.
    Citations:    Fields:    Translation:Humans
  128. Winkelman JW, Johnston L. Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS). Sleep Med. 2004 Jan; 5(1):9-14. PMID: 14725821.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  129. Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J. Panel discussion: changing how we think about insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:44-6. PMID: 15153067.
    Citations:    Fields:    Translation:Humans
  130. Winkelman JW. Treatment of nocturnal eating syndrome and sleep-related eating disorder with topiramate. Sleep Med. 2003 May; 4(3):243-6. PMID: 14592329.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.